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ONTOLOGY REPORT - ANNOTATIONS


Term:hydroxychloroquine
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Accession:CHEBI:5801 term browser browse the term
Definition:An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Synonyms:exact_synonym: 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
 related_synonym: 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol;   2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol;   7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline;   7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline;   7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline;   Formula=C18H26ClN3O;   InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21);   InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N;   NSC4375;   Polirreumin;   SMILES=CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12;   hidroxicloroquina;   hydroxychloroquinum;   oxichlorochine;   oxichloroquine
 xref: CAS:118-42-3;   DrugBank:DB01611;   Drug_Central:1395;   HMDB:HMDB0015549;   KEGG:C07043;   KEGG:D08050;   LINCS:LSM-5193
 xref_mesh: MESH:D006886
 xref: PMID:23216212;   PMID:23218706;   PMID:23481418;   PMID:23485647;   PMID:23581274;   PMID:23778483;   PMID:23887202;   PMID:23902281;   Patent:US2546658;   Reaxys:253894;   Wikipedia:Hydroxychloroquine
 cyclic_relationship: is_conjugate_base_of CHEBI:149564


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hydroxychloroquine term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:6480464
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:6480464
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:6480464
G Cd14 CD14 molecule JBrowse link 18 29,560,341 29,562,290 RGD:6480464
G Cd19 CD19 molecule JBrowse link 1 197,815,422 197,822,123 RGD:6480464
G Cd27 CD27 molecule JBrowse link 4 157,744,881 157,751,609 RGD:6480464
G Cd38 CD38 molecule JBrowse link 14 71,714,768 71,754,990 RGD:6480464
G Cd3d CD3d molecule JBrowse link 8 49,282,502 49,287,095 RGD:6480464
G Cd40lg CD40 ligand JBrowse link X 159,703,703 159,714,886 RGD:6480464
G Cd74 CD74 molecule JBrowse link 18 56,071,420 56,080,851 RGD:6480464
G Cflar CASP8 and FADD-like apoptosis regulator JBrowse link 9 65,534,608 65,586,395 RGD:6480464
G Cldn1 claudin 1 JBrowse link 11 77,815,216 77,830,373 RGD:6480464
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 JBrowse link 9 67,699,397 67,706,068 RGD:6480464
G Ctsb cathepsin B JBrowse link 15 46,316,741 46,337,613 RGD:6480464
G Cxcl1 C-X-C motif chemokine ligand 1 JBrowse link 14 18,743,678 18,745,457 RGD:6480464
G Cxcl3 C-X-C motif chemokine ligand 3 JBrowse link 14 18,820,168 18,839,659 RGD:6480464
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 JBrowse link 7 123,599,264 123,608,436 RGD:6480464
G Fas Fas cell surface death receptor JBrowse link 1 252,589,785 252,624,790 RGD:6480464
G Il10 interleukin 10 JBrowse link 13 47,738,933 47,743,392 RGD:6480464
G Il10ra interleukin 10 receptor subunit alpha JBrowse link 8 49,558,062 49,573,891 RGD:6480464
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:6480464
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:6480464
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:6480464
G Itk IL2-inducible T-cell kinase JBrowse link 10 31,431,820 31,493,413 RGD:6480464
G Jchain joining chain of multimeric IgA and IgM JBrowse link 14 21,176,841 21,183,731 RGD:6480464
G Lck LCK proto-oncogene, Src family tyrosine kinase JBrowse link 5 147,750,976 147,779,627 RGD:6480464
G Mmp1 matrix metallopeptidase 1 JBrowse link 8 5,703,206 5,723,593 RGD:6480464
G Ms4a1 membrane spanning 4-domains A1 JBrowse link 1 227,429,241 227,441,492 RGD:6480464
G Nfatc1 nuclear factor of activated T-cells 1 JBrowse link 18 77,203,517 77,322,690 RGD:6480464
G Nfatc2 nuclear factor of activated T-cells 2 JBrowse link 3 165,241,750 165,374,644 RGD:6480464
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:6480464
G Ocln occludin JBrowse link 2 30,527,327 30,577,218 RGD:6480464
G Ppt1 palmitoyl-protein thioesterase 1 JBrowse link 5 140,538,260 140,558,163 RGD:6480464
G Prdm1 PR/SET domain 1 JBrowse link 20 49,464,921 49,556,623 RGD:6480464
G Rasgrp1 RAS guanyl releasing protein 1 JBrowse link 3 108,984,029 109,044,420 RGD:6480464
G Sdc1 syndecan 1 JBrowse link 6 33,885,576 33,908,038 RGD:6480464
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:6480464
G Slamf7 SLAM family member 7 JBrowse link 13 90,056,726 90,075,159 RGD:6480464
G Sqstm1 sequestosome 1 JBrowse link 10 35,704,728 35,716,316 RGD:6480464
G Tlr7 toll-like receptor 7 JBrowse link X 28,486,836 28,513,004 RGD:6480464
G Tlr9 toll-like receptor 9 JBrowse link 8 114,916,122 114,920,171 RGD:6480464
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:6480464
G Tnfrsf17 TNF receptor superfamily member 17 JBrowse link 10 4,252,097 4,258,335 RGD:6480464
G Txnip thioredoxin interacting protein JBrowse link 2 198,683,168 198,686,971 RGD:6480464
G Xbp1 X-box binding protein 1 JBrowse link 14 85,753,736 85,758,820 RGD:6480464

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19764
    role 19710
      biological role 19709
        antimicrobial agent 17272
          antiviral agent 10178
            anticoronaviral agent 8901
              hydroxychloroquine 45
Path 2
Term Annotations click to browse term
  CHEBI ontology 19764
    subatomic particle 19762
      composite particle 19762
        hadron 19762
          baryon 19762
            nucleon 19762
              atomic nucleus 19762
                atom 19762
                  main group element atom 19645
                    main group molecular entity 19645
                      s-block molecular entity 19408
                        hydrogen molecular entity 19397
                          hydrides 18359
                            inorganic hydride 17218
                              pnictogen hydride 17182
                                nitrogen hydride 17015
                                  azane 16709
                                    ammonia 16707
                                      organic amino compound 16706
                                        aromatic amine 13614
                                          aminoquinoline 1646
                                            chloroquine 229
                                              hydroxychloroquine 45
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.