CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxychloroquine
Accession: CHEBI:5801
browse the term
Definition: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Synonyms: exact_synonym: 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
related_synonym: 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; 2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline; 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline; Formula=C18H26ClN3O; InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21); InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N; NSC4375; Polirreumin; SMILES=CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12; hidroxicloroquina; hydroxychloroquinum; oxichlorochine; oxichloroquine
xref: CAS:118-42-3; DrugBank:DB01611; Drug_Central:1395; HMDB:HMDB0015549; KEGG:C07043; KEGG:D08050; LINCS:LSM-5193
xref_mesh: MESH:D006886
xref: PMCID:PMC7122276; PMID:23216212; PMID:23218706; PMID:23481418; PMID:23485647; PMID:23581274; PMID:23778483; PMID:23887202; PMID:23902281; PMID:32215614; PMID:32269046; PMID:32283236; PMID:32294807; PMID:32295788; PMID:32295814; PMID:32311324; PMID:32327429; Patent:US2546658; Reaxys:253894; Wikipedia:Hydroxychloroquine
cyclic_relationship: is_conjugate_base_of CHEBI:149564
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Alpl
alkaline phosphatase, biomineralization associated
affects expression multiple interactions
ISO
Hydroxychloroquine affects the expression of ALPL mRNA Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]
CTD
PMID:28975700
NCBI chr 5:149,951,397...150,006,424
Ensembl chr 5:149,951,409...150,006,446
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases activity
ISO
bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein]
CTD
PMID:12813466
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcl2
BCL2, apoptosis regulator
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]
CTD
PMID:36843289
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Casp3
caspase 3
multiple interactions increases activity increases cleavage
ISO
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Hydroxychloroquine results in increased cleavage of CASP3 protein]; FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein]
CTD
PMID:12813466 PMID:16734620
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
Hydroxychloroquine results in increased expression of CCL2 mRNA
CTD
PMID:15139008
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Cd14
CD14 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA
CTD
PMID:28863153
NCBI chr18:28,335,522...28,337,383
Ensembl chr18:28,335,340...28,337,261
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Cd19
CD19 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA
CTD
PMID:28863153
NCBI chr 1:180,987,286...180,993,920
Ensembl chr 1:180,987,286...180,993,975
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Cd27
CD27 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA
CTD
PMID:28863153
NCBI chr 4:158,030,700...158,035,862
Ensembl chr 4:158,030,703...158,035,592
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Cd38
CD38 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA
CTD
PMID:28863153
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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Cd3d
CD3 delta subunit of T-cell receptor complex
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA
CTD
PMID:28863153
NCBI chr 8:45,287,803...45,293,342
Ensembl chr 8:45,288,749...45,301,809
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Cd40lg
CD40 ligand
decreases expression
ISO
Hydroxychloroquine results in decreased expression of CD40LG protein
CTD
PMID:28793932
NCBI chr X:135,127,052...135,138,768
Ensembl chr X:135,126,969...135,138,306
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Cd74
CD74 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA
CTD
PMID:28863153
NCBI chr18:54,256,757...54,266,003
Ensembl chr18:54,256,778...54,266,003
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Cflar
CASP8 and FADD-like apoptosis regulator
decreases expression
ISO
Hydroxychloroquine results in decreased expression of CFLAR mRNA; Hydroxychloroquine results in decreased expression of CFLAR protein
CTD
PMID:16734620
NCBI chr 9:60,185,338...60,236,173
Ensembl chr 9:60,185,452...60,237,034
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Cldn1
claudin 1
increases expression
ISO
Hydroxychloroquine results in increased expression of CLDN1 mRNA
CTD
PMID:25752684
NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA
CTD
PMID:28863153
NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
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Ctsb
cathepsin B
affects localization multiple interactions
ISO
Hydroxychloroquine affects the localization of CTSB protein bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein]
CTD
PMID:12813466
NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
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Cxcl1
C-X-C motif chemokine ligand 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA
CTD
PMID:28863153
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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Cxcl10
C-X-C motif chemokine ligand 10
increases expression
ISO
Hydroxychloroquine results in increased expression of CXCL10 mRNA
CTD
PMID:25321315
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA
CTD
PMID:28863153
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions decreases activity
ISO
Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] Hydroxychloroquine results in decreased activity of CYP2D6 protein
CTD
PMID:10848718
NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
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Dhcr7
7-dehydrocholesterol reductase
affects expression multiple interactions
ISO
Hydroxychloroquine affects the expression of DHCR7 mRNA Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]
CTD
PMID:28975700
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
Hydroxychloroquine results in increased expression of ERN1 protein
CTD
PMID:25321315
NCBI chr10:91,326,889...91,421,201
Ensembl chr10:91,330,654...91,421,029
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Fas
Fas cell surface death receptor
multiple interactions
ISO
FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein]
CTD
PMID:16734620
NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions affects expression
ISO
Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]
CTD
PMID:28975700
NCBI chr 2:27,997,523...28,018,983
Ensembl chr 2:27,997,525...28,019,703
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Ifih1
interferon induced with helicase C domain 1
increases expression
ISO
Hydroxychloroquine results in increased expression of IFIH1 mRNA
CTD
PMID:25321315
NCBI chr 3:47,228,980...47,275,403
Ensembl chr 3:47,227,364...47,275,456
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
increases expression
ISO
Hydroxychloroquine results in increased expression of IFIT3 mRNA
CTD
PMID:25321315
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
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Ifnb1
interferon beta 1
increases expression
ISO
Hydroxychloroquine results in increased expression of IFNB1 mRNA
CTD
PMID:25321315
NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523
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Il10
interleukin 10
multiple interactions
ISO
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein
CTD
PMID:31082466
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il10ra
interleukin 10 receptor subunit alpha
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA
CTD
PMID:28863153
NCBI chr 8:45,563,009...45,578,041
Ensembl chr 8:45,563,137...45,578,061
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Il12b
interleukin 12B
increases expression
ISO
Hydroxychloroquine results in increased expression of IL12B mRNA
CTD
PMID:25321315
NCBI chr10:28,888,832...28,903,802
Ensembl chr10:28,893,008...28,902,903
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Il1b
interleukin 1 beta
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of IL1B protein]
CTD
PMID:16393772 PMID:32314717
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il23a
interleukin 23 subunit alpha
increases expression
ISO
Hydroxychloroquine results in increased expression of IL23A mRNA
CTD
PMID:25321315
NCBI chr 7:721,809...723,923
Ensembl chr 7:721,809...723,923
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Il6
interleukin 6
multiple interactions increases expression
ISO
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; [Hydroxychloroquine co-treated with ODN2006] results in increased secretion of IL6 protein; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Hydroxychloroquine results in increased expression of IL6 mRNA
CTD
PMID:9002011 PMID:25321315 PMID:31082466
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Irf3
interferon regulatory factor 3
increases expression increases phosphorylation multiple interactions
ISO
Hydroxychloroquine results in increased expression of IRF3 mRNA Hydroxychloroquine results in increased phosphorylation of IRF3 protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of IRF3 protein]
CTD
PMID:25321315
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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Irf4
interferon regulatory factor 4
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA
CTD
PMID:28863153
NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
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Irf7
interferon regulatory factor 7
increases expression
ISO
Hydroxychloroquine results in increased expression of IRF7 mRNA
CTD
PMID:25321315
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
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Itk
IL2-inducible T-cell kinase
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA
CTD
PMID:28863153
NCBI chr10:30,753,344...30,814,685
Ensembl chr10:30,753,344...30,814,685
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Jchain
joining chain of multimeric IgA and IgM
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA
CTD
PMID:28863153
NCBI chr14:19,538,927...19,547,023
Ensembl chr14:19,538,952...19,546,298
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation multiple interactions
ISO
Hydroxychloroquine results in increased phosphorylation of JUN protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of JUN protein]
CTD
PMID:25321315
NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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Kcnh2
potassium voltage-gated channel subfamily H member 2
multiple interactions
ISO
[Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein
CTD
PMID:34058295
NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
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Lck
LCK proto-oncogene, Src family tyrosine kinase
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA
CTD
PMID:28863153
NCBI chr 5:141,888,318...141,916,945
Ensembl chr 5:141,888,326...141,903,794
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Mavs
mitochondrial antiviral signaling protein
increases expression multiple interactions
ISO
Hydroxychloroquine results in increased expression of MAVS mRNA; Hydroxychloroquine results in increased expression of MAVS protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased expression of MAVS protein]
CTD
PMID:25321315
NCBI chr 3:118,451,650...118,466,094
Ensembl chr 3:118,451,743...118,466,094
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Mmp1
matrix metallopeptidase 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA
CTD
PMID:28863153
NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
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Mmp2
matrix metallopeptidase 2
multiple interactions decreases expression
ISO
Sirolimus inhibits the reaction [Hydroxychloroquine results in decreased expression of MMP2 protein] Hydroxychloroquine results in decreased expression of MMP2 mRNA; Hydroxychloroquine results in decreased expression of MMP2 protein
CTD
PMID:34278709
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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Ms4a1
membrane spanning 4-domains A1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA
CTD
PMID:28863153
NCBI chr 1:207,906,370...207,927,028
Ensembl chr 1:207,906,374...207,918,512
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Mvp
major vault protein
increases expression
ISO
Hydroxychloroquine results in increased expression of MVP mRNA
CTD
PMID:25321315
NCBI chr 1:181,594,734...181,622,336
Ensembl chr 1:181,594,734...181,622,380
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Nfatc1
nuclear factor of activated T-cells 1
affects expression
ISO
Hydroxychloroquine affects the expression of NFATC1 protein
CTD
PMID:28793932
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
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Nfatc2
nuclear factor of activated T-cells 2
affects localization
ISO
Hydroxychloroquine affects the localization of NFATC2 protein
CTD
PMID:28793932
NCBI chr 3:157,195,970...157,328,640
Ensembl chr 3:157,198,872...157,328,325
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Nfkbia
NFKB inhibitor alpha
multiple interactions increases degradation
ISO
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased degradation of NFKBIA protein]
CTD
PMID:25321315
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
CTD
PMID:16393772
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Ocln
occludin
increases expression
ISO
Hydroxychloroquine results in increased expression of OCLN mRNA
CTD
PMID:25752684
NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
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Parp1
poly (ADP-ribose) polymerase 1
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]
CTD
PMID:36843289
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Ppt1
palmitoyl-protein thioesterase 1
multiple interactions
ISO
Hydroxychloroquine binds to and results in decreased activity of PPT1 protein
CTD
PMID:30442709
NCBI chr 5:135,121,164...135,142,048
Ensembl chr 5:135,121,163...135,142,048
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Prdm1
PR/SET domain 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA
CTD
PMID:28863153
NCBI chr20:47,959,858...47,981,488
Ensembl chr20:47,959,858...47,981,488
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Rasgrp1
RAS guanyl releasing protein 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA
CTD
PMID:28863153
NCBI chr 3:104,168,549...104,230,107
Ensembl chr 3:104,170,013...104,230,056
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
ISO
Hydroxychloroquine results in increased expression of RELA protein
CTD
PMID:25321315
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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Rig1
RNA sensor RIG-1
increases expression
ISO
Hydroxychloroquine results in increased expression of RIGI mRNA
CTD
PMID:25321315
NCBI chr 5:55,321,351...55,369,947
Ensembl chr 5:55,321,235...55,370,819
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
Hydroxychloroquine results in increased expression of RSAD2 mRNA
CTD
PMID:25321315
NCBI chr 6:43,046,514...43,059,737
Ensembl chr 6:43,047,658...43,059,699
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Sdc1
syndecan 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA
CTD
PMID:28863153
NCBI chr 6:31,562,799...31,585,267
Ensembl chr 6:31,562,739...31,585,264
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Serpine1
serpin family E member 1
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]
CTD
PMID:30341573
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Slamf7
SLAM family member 7
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA
CTD
PMID:28863153
NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105
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Sqstm1
sequestosome 1
multiple interactions increases expression
ISO
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]] Hydroxychloroquine results in increased expression of SQSTM1 protein [Dronabinol co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein; [HU 211 co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein
CTD
PMID:29426000 PMID:32773031
NCBI chr10:34,525,517...34,536,670
Ensembl chr10:34,525,519...34,536,673
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Tlr7
toll-like receptor 7
decreases expression
ISO
Hydroxychloroquine results in decreased expression of TLR7 protein
CTD
PMID:22513098
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
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Tlr9
toll-like receptor 9
decreases expression multiple interactions
ISO
Hydroxychloroquine results in decreased expression of TLR9 protein Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of TLR9 protein]
CTD
PMID:22513098 PMID:32314717
NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Hydroxychloroquine results in increased expression of TNF mRNA
CTD
PMID:9002011 PMID:25321315 PMID:28863153
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfrsf17
TNF receptor superfamily member 17
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA
CTD
PMID:28863153
NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788
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Traf3
Tnf receptor-associated factor 3
increases expression
ISO
Hydroxychloroquine results in increased expression of TRAF3 mRNA
CTD
PMID:25321315
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
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Traf6
TNF receptor associated factor 6
increases expression
ISO
Hydroxychloroquine results in increased expression of TRAF6 mRNA
CTD
PMID:25321315
NCBI chr 3:87,963,517...87,988,316
Ensembl chr 3:87,963,514...87,983,507
G
Trim21
tripartite motif-containing 21
increases expression
ISO
Hydroxychloroquine results in increased expression of TRIM21 mRNA
CTD
PMID:25321315
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
G
Txnip
thioredoxin interacting protein
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]
CTD
PMID:29426000
NCBI chr 2:184,093,079...184,096,882
Ensembl chr 2:184,092,991...184,096,886
G
Uxt
ubiquitously-expressed, prefoldin-like chaperone
increases expression
ISO
Hydroxychloroquine results in increased expression of UXT mRNA
CTD
PMID:25321315
NCBI chr X:1,126,110...1,138,670
Ensembl chr X:1,126,162...1,138,663
G
Vcl
vinculin
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of VCL protein]
CTD
PMID:28975700
NCBI chr15:3,265,776...3,355,586
Ensembl chr15:3,265,815...3,355,606
G
Xbp1
X-box binding protein 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA
CTD
PMID:28863153
NCBI chr14:80,390,629...80,395,713
Ensembl chr14:80,390,643...80,395,693
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