CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: hydroxychloroquine
Accession: CHEBI:5801
browse the term
Definition: An aminoquinoline that is chloroquine in which one of the N-ethyl groups is hydroxylated at position 2. An antimalarial with properties similar to chloroquine that acts against erythrocytic forms of malarial parasites, it is mainly used as the sulfate salt for the treatment of lupus erythematosus, rheumatoid arthritis, and light-sensitive skin eruptions.
Synonyms: exact_synonym: 2-[{4-[(7-chloroquinolin-4-yl)amino]pentyl}(ethyl)amino]ethanol
related_synonym: 2-((4-((7-chloro-4-quinolyl)amino)pentyl)ethylamino)ethanol; 2-(N-(4-(7-chlor-4-chinolylamino)-4-methylbutyl)ethylamino)ethanol; 7-chloro-4-(4-(ethyl(2-hydroxyethyl)amino)-1-methylbutylamino)quinoline; 7-chloro-4-[4-(N-ethyl-N-beta-hydroxyethylamino)-1-methylbutylamino]quinoline; 7-chloro-4-[5-(N-ethyl-N-2-hydroxyethylamino)-2-pentyl]aminoquinoline; Formula=C18H26ClN3O; InChI=1S/C18H26ClN3O/c1-3-22(11-12-23)10-4-5-14(2)21-17-8-9-20-18-13-15(19)6-7-16(17)18/h6-9,13-14,23H,3-5,10-12H2,1-2H3,(H,20,21); InChIKey=XXSMGPRMXLTPCZ-UHFFFAOYSA-N; NSC4375; Polirreumin; SMILES=CCN(CCO)CCCC(C)Nc1ccnc2cc(Cl)ccc12; hidroxicloroquina; hydroxychloroquinum; oxichlorochine; oxichloroquine
xref: CAS:118-42-3; DrugBank:DB01611; Drug_Central:1395; HMDB:HMDB0015549; KEGG:C07043; KEGG:D08050; LINCS:LSM-5193
xref_mesh: MESH:D006886
xref: PMCID:PMC7122276; PMID:23216212; PMID:23218706; PMID:23481418; PMID:23485647; PMID:23581274; PMID:23778483; PMID:23887202; PMID:23902281; PMID:32215614; PMID:32269046; PMID:32283236; PMID:32294807; PMID:32295788; PMID:32295814; PMID:32311324; PMID:32327429; Patent:US2546658; Reaxys:253894; Wikipedia:Hydroxychloroquine
cyclic_relationship: is_conjugate_base_of CHEBI:149564
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Alpl
alkaline phosphatase, biomineralization associated
affects expression multiple interactions
ISO
Hydroxychloroquine affects the expression of ALPL mRNA Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]
CTD
PMID:28975700
NCBI chr 5:156,086,496...156,141,513
Ensembl chr 5:156,086,497...156,141,537
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Bax
BCL2 associated X, apoptosis regulator
multiple interactions increases activity
ISO
bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein]
CTD
PMID:12813466
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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Casp3
caspase 3
multiple interactions increases cleavage increases activity
ISO
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Hydroxychloroquine results in increased cleavage of CASP3 protein]; FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein]
CTD
PMID:12813466 PMID:16734620
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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Ccl2
C-C motif chemokine ligand 2
increases expression
ISO
Hydroxychloroquine results in increased expression of CCL2 mRNA
CTD
PMID:15139008
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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Cd14
CD14 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA
CTD
PMID:28863153
NCBI chr18:29,560,341...29,562,290
Ensembl chr18:29,560,365...29,562,153
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Cd19
CD19 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA
CTD
PMID:28863153
NCBI chr 1:197,815,422...197,822,123
Ensembl chr 1:197,815,413...197,821,936
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Cd27
CD27 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA
CTD
PMID:28863153
NCBI chr 4:157,744,881...157,751,609
Ensembl chr 4:157,744,882...157,750,088
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Cd38
CD38 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA
CTD
PMID:28863153
NCBI chr14:71,714,768...71,754,990
Ensembl chr14:71,715,269...71,754,672
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Cd3d
CD3d molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA
CTD
PMID:28863153
NCBI chr 8:49,282,502...49,287,095
Ensembl chr 8:49,282,460...49,287,110
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Cd40lg
CD40 ligand
decreases expression
ISO
Hydroxychloroquine results in decreased expression of CD40LG protein
CTD
PMID:28793932
NCBI chr X:159,703,703...159,714,886
Ensembl chr X:159,703,578...159,716,562
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Cd74
CD74 molecule
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA
CTD
PMID:28863153
NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
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Cflar
CASP8 and FADD-like apoptosis regulator
decreases expression
ISO
Hydroxychloroquine results in decreased expression of CFLAR mRNA; Hydroxychloroquine results in decreased expression of CFLAR protein
CTD
PMID:16734620
NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
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Cldn1
claudin 1
increases expression
ISO
Hydroxychloroquine results in increased expression of CLDN1 mRNA
CTD
PMID:25752684
NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
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Ctla4
cytotoxic T-lymphocyte-associated protein 4
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA
CTD
PMID:28863153
NCBI chr 9:67,699,397...67,706,068
Ensembl chr 9:67,699,379...67,706,065
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Ctsb
cathepsin B
affects localization multiple interactions
ISO
Hydroxychloroquine affects the localization of CTSB protein bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein]
CTD
PMID:12813466
NCBI chr15:46,316,741...46,337,613
Ensembl chr15:46,316,741...46,337,612
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Cxcl1
C-X-C motif chemokine ligand 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA
CTD
PMID:28863153
NCBI chr14:18,743,678...18,745,457
Ensembl chr14:18,743,685...18,745,457
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Cxcl10
C-X-C motif chemokine ligand 10
increases expression
ISO
Hydroxychloroquine results in increased expression of CXCL10 mRNA
CTD
PMID:25321315
NCBI chr14:17,210,733...17,212,930
Ensembl chr14:17,210,733...17,212,930
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Cxcl3
C-X-C motif chemokine ligand 3
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA
CTD
PMID:28863153
NCBI chr14:18,820,168...18,839,659
Ensembl chr14:18,820,168...18,839,595
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Cyp2d4
cytochrome P450, family 2, subfamily d, polypeptide 4
multiple interactions decreases activity
ISO
Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] Hydroxychloroquine results in decreased activity of CYP2D6 protein
CTD
PMID:10848718
NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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Ddx58
DEXD/H-box helicase 58
increases expression
ISO
Hydroxychloroquine results in increased expression of DDX58 mRNA
CTD
PMID:25321315
NCBI chr 5:56,486,584...56,536,898
Ensembl chr 5:56,500,734...56,536,772
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Dhcr7
7-dehydrocholesterol reductase
affects expression multiple interactions
ISO
Hydroxychloroquine affects the expression of DHCR7 mRNA Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]
CTD
PMID:28975700
NCBI chr 1:217,018,916...217,034,890
Ensembl chr 1:217,018,916...217,034,904
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Ern1
endoplasmic reticulum to nucleus signaling 1
increases expression
ISO
Hydroxychloroquine results in increased expression of ERN1 protein
CTD
PMID:25321315
NCBI chr10:94,588,555...94,682,072
Ensembl chr10:94,588,555...94,681,914
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Fas
Fas cell surface death receptor
multiple interactions
ISO
FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein]
CTD
PMID:16734620
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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Hmgcr
3-hydroxy-3-methylglutaryl-CoA reductase
multiple interactions affects expression
ISO
Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]
CTD
PMID:28975700
NCBI chr 2:27,480,224...27,500,654
Ensembl chr 2:27,480,226...27,500,654
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Ifih1
interferon induced with helicase C domain 1
increases expression
ISO
Hydroxychloroquine results in increased expression of IFIH1 mRNA
CTD
PMID:25321315
NCBI chr 3:48,557,696...48,604,097
Ensembl chr 3:48,557,696...48,604,097
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Ifit3
interferon-induced protein with tetratricopeptide repeats 3
increases expression
ISO
Hydroxychloroquine results in increased expression of IFIT3 mRNA
CTD
PMID:25321315
NCBI chr 1:252,906,234...252,911,377
Ensembl chr 1:252,906,234...252,911,382
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Ifnb1
interferon beta 1
increases expression
ISO
Hydroxychloroquine results in increased expression of IFNB1 mRNA
CTD
PMID:25321315
NCBI chr 5:106,865,192...106,865,746
Ensembl chr 5:106,865,192...106,865,746
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Il10
interleukin 10
multiple interactions
ISO
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein
CTD
PMID:31082466
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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Il10ra
interleukin 10 receptor subunit alpha
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA
CTD
PMID:28863153
NCBI chr 8:49,558,062...49,573,891
Ensembl chr 8:49,560,035...49,573,742
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Il12b
interleukin 12B
increases expression
ISO
Hydroxychloroquine results in increased expression of IL12B mRNA
CTD
PMID:25321315
NCBI chr10:30,034,447...30,048,774
Ensembl chr10:30,038,709...30,048,085
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Il1b
interleukin 1 beta
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of IL1B protein]
CTD
PMID:16393772 PMID:32314717
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il23a
interleukin 23 subunit alpha
increases expression
ISO
Hydroxychloroquine results in increased expression of IL23A mRNA
CTD
PMID:25321315
NCBI chr 7:2,710,609...2,712,723
Ensembl chr 7:2,710,609...2,712,723
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Il6
interleukin 6
multiple interactions increases expression
ISO
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; [Hydroxychloroquine co-treated with ODN2006] results in increased secretion of IL6 protein; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Hydroxychloroquine results in increased expression of IL6 mRNA
CTD
PMID:9002011 PMID:25321315 PMID:31082466
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Irf3
interferon regulatory factor 3
increases expression multiple interactions increases phosphorylation
ISO
Hydroxychloroquine results in increased expression of IRF3 mRNA phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of IRF3 protein]
CTD
PMID:25321315
NCBI chr 1:100,992,244...100,997,202
Ensembl chr 1:100,992,405...100,997,198
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Irf4
interferon regulatory factor 4
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA
CTD
PMID:28863153
NCBI chr17:34,886,746...34,905,191
Ensembl chr17:34,886,739...34,905,117
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Irf7
interferon regulatory factor 7
increases expression
ISO
Hydroxychloroquine results in increased expression of IRF7 mRNA
CTD
PMID:25321315
NCBI chr 1:214,249,388...214,252,909
Ensembl chr 1:214,248,837...214,252,456
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Itk
IL2-inducible T-cell kinase
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA
CTD
PMID:28863153
NCBI chr10:31,431,820...31,493,413
Ensembl chr10:31,431,809...31,493,419
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Jchain
joining chain of multimeric IgA and IgM
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA
CTD
PMID:28863153
NCBI chr14:21,176,841...21,183,731
Ensembl chr14:21,177,237...21,183,542
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Jun
Jun proto-oncogene, AP-1 transcription factor subunit
increases phosphorylation multiple interactions
ISO
Hydroxychloroquine results in increased phosphorylation of JUN protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of JUN protein]
CTD
PMID:25321315
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Lck
LCK proto-oncogene, Src family tyrosine kinase
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA
CTD
PMID:28863153
NCBI chr 5:147,750,976...147,779,627
Ensembl chr 5:147,750,973...147,761,983
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Mavs
mitochondrial antiviral signaling protein
increases expression multiple interactions
ISO
Hydroxychloroquine results in increased expression of MAVS mRNA; Hydroxychloroquine results in increased expression of MAVS protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased expression of MAVS protein]
CTD
PMID:25321315
NCBI chr 3:123,776,147...123,790,572
Ensembl chr 3:123,776,181...123,790,567
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Mmp1
matrix metallopeptidase 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA
CTD
PMID:28863153
NCBI chr 8:5,703,206...5,723,593
Ensembl chr 8:5,703,206...5,723,591
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Ms4a1
membrane spanning 4-domains A1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA
CTD
PMID:28863153
NCBI chr 1:227,429,241...227,441,492
Ensembl chr 1:227,429,596...227,441,442
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Mvp
major vault protein
increases expression
ISO
Hydroxychloroquine results in increased expression of MVP mRNA
CTD
PMID:25321315
NCBI chr 1:198,420,813...198,448,612
Ensembl chr 1:198,420,806...198,450,047
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Nfatc1
nuclear factor of activated T-cells 1
affects expression
ISO
Hydroxychloroquine affects the expression of NFATC1 protein
CTD
PMID:28793932
NCBI chr18:77,203,517...77,322,690
Ensembl chr18:77,203,525...77,322,690
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Nfatc2
nuclear factor of activated T-cells 2
affects localization
ISO
Hydroxychloroquine affects the localization of NFATC2 protein
CTD
PMID:28793932
NCBI chr 3:165,241,750...165,374,644
Ensembl chr 3:165,245,238...165,360,292
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Nfkbia
NFKB inhibitor alpha
multiple interactions increases degradation
ISO
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased degradation of NFKBIA protein]
CTD
PMID:25321315
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Nos2
nitric oxide synthase 2
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
CTD
PMID:16393772
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Ocln
occludin
increases expression
ISO
Hydroxychloroquine results in increased expression of OCLN mRNA
CTD
PMID:25752684
NCBI chr 2:30,527,327...30,577,218
Ensembl chr 2:30,527,715...30,577,218
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Ppt1
palmitoyl-protein thioesterase 1
multiple interactions
ISO
Hydroxychloroquine binds to and results in decreased activity of PPT1 protein
CTD
PMID:30442709
NCBI chr 5:140,538,260...140,558,163
Ensembl chr 5:140,538,260...140,558,162
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Prdm1
PR/SET domain 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA
CTD
PMID:28863153
NCBI chr20:49,464,921...49,556,623
Ensembl chr20:49,464,919...49,556,518
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Rasgrp1
RAS guanyl releasing protein 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA
CTD
PMID:28863153
NCBI chr 3:108,984,029...109,044,420
Ensembl chr 3:108,984,029...109,044,420
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Rela
RELA proto-oncogene, NF-kB subunit
increases expression
ISO
Hydroxychloroquine results in increased expression of RELA protein
CTD
PMID:25321315
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Rsad2
radical S-adenosyl methionine domain containing 2
increases expression
ISO
Hydroxychloroquine results in increased expression of RSAD2 mRNA
CTD
PMID:25321315
NCBI chr 6:45,655,947...45,669,083
Ensembl chr 6:45,655,954...45,669,148
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Sdc1
syndecan 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA
CTD
PMID:28863153
NCBI chr 6:33,885,576...33,908,038
Ensembl chr 6:33,885,495...33,908,016
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Serpine1
serpin family E member 1
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]
CTD
PMID:30341573
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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Slamf7
SLAM family member 7
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA
CTD
PMID:28863153
NCBI chr13:90,056,726...90,075,159
Ensembl chr13:90,058,127...90,075,144
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Sqstm1
sequestosome 1
multiple interactions increases expression
ISO
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]] Hydroxychloroquine results in increased expression of SQSTM1 protein [Dronabinol co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein; [HU 211 co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein
CTD
PMID:29426000 PMID:32773031
NCBI chr10:35,704,728...35,716,316
Ensembl chr10:35,704,730...35,716,294
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Tlr7
toll-like receptor 7
decreases expression
ISO
Hydroxychloroquine results in decreased expression of TLR7 protein
CTD
PMID:22513098
NCBI chr X:28,486,836...28,513,004
Ensembl chr X:28,486,869...28,512,957
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Tlr9
toll-like receptor 9
decreases expression multiple interactions
ISO
Hydroxychloroquine results in decreased expression of TLR9 protein Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of TLR9 protein]
CTD
PMID:22513098 PMID:32314717
NCBI chr 8:114,916,122...114,920,171
Ensembl chr 8:114,916,122...114,920,171
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Tnf
tumor necrosis factor
multiple interactions increases expression
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Hydroxychloroquine results in increased expression of TNF mRNA
CTD
PMID:9002011 PMID:25321315 PMID:28863153
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 Ensembl chr20:5,189,390...5,192,000
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Tnfrsf17
TNF receptor superfamily member 17
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA
CTD
PMID:28863153
NCBI chr10:4,252,097...4,258,335
Ensembl chr10:4,251,941...4,257,868
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Traf3
Tnf receptor-associated factor 3
increases expression
ISO
Hydroxychloroquine results in increased expression of TRAF3 mRNA
CTD
PMID:25321315
NCBI chr 6:135,610,698...135,720,247
Ensembl chr 6:135,610,743...135,718,564
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Traf6
TNF receptor associated factor 6
increases expression
ISO
Hydroxychloroquine results in increased expression of TRAF6 mRNA
CTD
PMID:25321315
NCBI chr 3:91,252,829...91,271,607
Ensembl chr 3:91,252,829...91,271,607
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Trim21
tripartite motif-containing 21
increases expression
ISO
Hydroxychloroquine results in increased expression of TRIM21 mRNA
CTD
PMID:25321315
NCBI chr 1:167,686,148...167,708,735
Ensembl chr 1:167,686,173...167,708,714
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Txnip
thioredoxin interacting protein
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]
CTD
PMID:29426000
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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Uxt
ubiquitously-expressed, prefoldin-like chaperone
increases expression
ISO
Hydroxychloroquine results in increased expression of UXT mRNA
CTD
PMID:25321315
NCBI chr X:1,275,402...1,287,781
Ensembl chr X:1,275,612...1,287,512
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Vcl
vinculin
multiple interactions
ISO
Hydroxychloroquine inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of VCL protein]
CTD
PMID:28975700
NCBI chr15:3,455,211...3,544,738
Ensembl chr15:3,455,211...3,544,702
G
Xbp1
X-box binding protein 1
multiple interactions
ISO
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA
CTD
PMID:28863153
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
Term paths to the root one shortest all shortest one longest all longest one shortest and longest all