Il3 (interleukin 3) - Rat Genome Database

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Gene: Il3 (interleukin 3) Mus musculus
Analyze
Symbol: Il3
Name: interleukin 3
RGD ID: 10793
MGI Page MGI
Description: Enables cytokine activity; growth factor activity; and interleukin-3 receptor binding activity. Acts upstream of or within several processes, including negative regulation of leukocyte apoptotic process; positive regulation of leukocyte proliferation; and regulation of phosphate metabolic process. Located in extracellular space. Is expressed in skin; stomach; thymus; and vascular system. Human ortholog(s) of this gene implicated in Graves ophthalmopathy; Graves' disease; asthma; and rheumatoid arthritis. Orthologous to human IL3 (interleukin 3).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: B; BPA; Csfm; Csfmu; HCGF; hematopoietic growth factor; Il; Il-3; interleukin-3; mast cell growth factor; MCGF; multipotential colony-stimulating factor; P; P-cell-stimulating factor; PSF
RGD Orthologs
Human
Rat
Bonobo
Dog
Squirrel
Green Monkey
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,155,911 - 54,158,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,156,129 - 54,158,103 (-)EnsemblGRCm39 Ensembl
GRCm381154,265,085 - 54,267,279 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,265,303 - 54,267,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,078,587 - 54,080,781 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,108,726 - 54,110,700 (-)NCBIMGSCv36mm8
Celera1158,854,078 - 58,856,272 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
1-chloro-2,4-dinitrobenzene  (EXP)
2,3,7,8-tetrachlorodibenzodioxine  (EXP)
3,5-diethoxycarbonyl-1,4-dihydrocollidine  (EXP)
4,4'-sulfonyldiphenol  (EXP)
4-(ethoxymethylene)-2-phenyloxazol-5-one  (EXP)
4-hydroxynon-2-enal  (ISO)
5-fluorouracil  (EXP)
acrolein  (EXP)
aflatoxin B1  (ISO)
alclometasone dipropionate  (ISO)
all-trans-retinoic acid  (ISO)
ammonium chloride  (ISO)
aspartame  (ISO)
beclomethasone  (ISO)
benzalkonium chloride  (EXP)
benzene  (EXP)
benzo[a]pyrene  (ISO)
benzoates  (EXP)
betamethasone valerate  (ISO)
bis(2-chloroethyl) sulfide  (ISO)
bisphenol A  (ISO)
cadmium dichloride  (ISO)
caffeine  (EXP)
Calcimycin  (EXP,ISO)
cannabidiol  (EXP)
capsaicin  (ISO)
chloroquine  (EXP)
ciprofloxacin  (EXP)
cyclophosphamide  (EXP)
cyclosporin A  (EXP)
dexamethasone  (ISO)
dioxygen  (EXP)
entinostat  (EXP)
ethanol  (ISO)
formaldehyde  (EXP)
hydralazine  (ISO)
ionomycin  (ISO)
lipopolysaccharide  (EXP)
luteolin  (ISO)
methotrexate  (EXP,ISO)
microcystin-LR  (EXP)
monodansylcadaverine  (EXP)
mycophenolic acid  (EXP)
N-acetyl-L-cysteine  (ISO)
N-formyl-L-methionyl-L-leucyl-L-phenylalanine  (EXP)
naproxen  (ISO)
neocuproine  (EXP)
nonanoic acid  (EXP)
p-menthan-3-ol  (ISO)
paracetamol  (ISO)
paraquat  (EXP)
phenylarsine oxide  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
resveratrol  (ISO)
sirolimus  (EXP)
sterigmatocystin  (EXP)
sumatriptan  (ISO)
tacrolimus hydrate  (EXP,ISO)
tert-butyl hydroperoxide  (ISO)
theophylline  (ISO)
titanium dioxide  (EXP)
toluene 2,4-diisocyanate  (EXP)
trichostatin A  (EXP)
trimellitic anhydride  (EXP)
triptonide  (EXP)
valproic acid  (EXP,ISO)
wortmannin  (ISO)
zidovudine  (EXP)
zinc atom  (ISO)
zinc dichloride  (EXP)
zinc oxide  (ISO)
zinc(0)  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of Janus kinase activity  (IDA)
B cell apoptotic process  (IDA)
B cell proliferation  (IDA)
cell population proliferation  (IDA,IGI)
cytokine-mediated signaling pathway  (IDA)
embryonic hemopoiesis  (ISO)
extrinsic apoptotic signaling pathway in absence of ligand  (IDA)
hematopoietic progenitor cell differentiation  (IGI)
hemopoiesis  (ISO)
immune response  (IEA)
interleukin-3-mediated signaling pathway  (IDA)
JNK cascade  (IDA,IMP)
mast cell apoptotic process  (IDA)
mast cell proliferation  (IDA)
monocyte differentiation  (IGI)
myeloid cell apoptotic process  (IDA)
myeloid leukocyte differentiation  (IGI)
negative regulation of autophagy  (IDA)
negative regulation of B cell apoptotic process  (IDA)
negative regulation of mast cell apoptotic process  (IDA)
negative regulation of myeloid cell apoptotic process  (IDA)
peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of B cell proliferation  (IDA)
positive regulation of cell population proliferation  (IDA,IGI,ISO)
positive regulation of hematopoietic progenitor cell differentiation  (IGI)
positive regulation of JNK cascade  (IDA,IMP)
positive regulation of mast cell proliferation  (IDA)
positive regulation of myeloid leukocyte differentiation  (IGI)
positive regulation of peptidyl-tyrosine phosphorylation  (IDA)
positive regulation of protein phosphorylation  (IDA)
positive regulation of T cell proliferation  (IDA)
positive regulation of tyrosine phosphorylation of STAT protein  (ISO)
protein phosphorylation  (IDA)
regulation of cell growth  (IGI,ISO)
regulation of gene expression  (IDA)
regulation of glycolytic process  (IGI)
regulation of protein dephosphorylation  (IDA)
response to hormone  (ISO)
response to hypoxia  (IGI)
signal transduction  (IDA)
T cell proliferation  (IDA)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
References

References - curated
# Reference Title Reference Citation
1. Adenovirus-mediated interleukin 3 beta gene transfer by isolated limb perfusion inhibits growth of limb sarcoma in rats. de Wilt JH, etal., Hum Gene Ther. 2001 Mar 20;12(5):489-502.
2. A dual role for the immune response in a mouse model of inflammation-associated lung cancer. Dougan M, etal., J Clin Invest. 2011 Jun 1;121(6):2436-46. doi: 10.1172/JCI44796. Epub 2011 May 2.
3. Strongyloides ratti infection induces transient nematode-specific Th2 response and reciprocal suppression of IFN-gamma production in mice. Eschbach ML, etal., Parasite Immunol. 2010 May;32(5):370-83.
4. Identification of a 5-protein biomarker molecular signature for predicting Alzheimer's disease. Gomez Ravetti M and Moscato P, PLoS One. 2008 Sep 3;3(9):e3111.
5. The cytokine response to human traumatic brain injury: temporal profiles and evidence for cerebral parenchymal production. Helmy A, etal., J Cereb Blood Flow Metab. 2011 Feb;31(2):658-70. Epub 2010 Aug 18.
6. Rheumatoid arthritis-associated gene-gene interaction network for rheumatoid arthritis candidate genes. Huang CH, etal., BMC Proc. 2009 Dec 15;3 Suppl 7:S75.
7. Global gene expression profiling of renal scarring in a rat model of pyelonephritis. Ichino M, etal., Pediatr Nephrol. 2008 Jul;23(7):1059-71. Epub 2008 Jan 23.
8. Electronic Transfer of Homolog Data MGD and Homologene mouse data transfer
9. MGDs mouse GO annotations MGD data from the GO Consortium
10. MGD IEA MGD IEA
11. IL3 SNP rs40401 variant is a risk factor for rhinoconjunctivitis in Japanese women: the Kyushu Okinawa maternal and child health study. Miyake Y, etal., Cytokine. 2013 Oct;64(1):86-9. doi: 10.1016/j.cyto.2013.07.020. Epub 2013 Aug 15.
12. IL3 rs40401 polymorphism and interaction with smoking in risk of asthma in Japanese women: the Kyushu Okinawa Maternal and Child Health study. Miyake Y, etal., Scand J Immunol. 2014 Jun;79(6):410-4. doi: 10.1111/sji.12171.
13. Hematopoietic cytokines in the sera of patients with pancreatic cancer. Mroczko B, etal., Clin Chem Lab Med. 2005;43(2):146-50.
14. Subcutaneous injection containing IL-3 and GM-CSF ameliorates stab wound-induced brain injury in rats. Nishihara T, etal., Exp Neurol. 2011 Jun;229(2):507-16. Epub 2011 Apr 16.
15. Interleukin 3 (IL3) polymorphisms associated with decreased risk of asthma and atopy. Park BL, etal., J Hum Genet. 2004;49(10):517-27. doi: 10.1007/s10038-004-0184-x. Epub 2004 Sep 11.
16. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
17. PID Annotation Import Pipeline Pipeline to import Pathway Interaction Database annotations from NCI into RGD
18. SMPDB Annotation Import Pipeline Pipeline to import SMPDB annotations from SMPDB into RGD
19. Classification and prediction of clinical Alzheimer's diagnosis based on plasma signaling proteins. Ray S, etal., Nat Med. 2007 Nov;13(11):1359-62. Epub 2007 Oct 14.
20. Mouse MP Annotation Import Pipeline RGD automated import pipeline
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. LHRH antagonist Cetrorelix reduces prostate size and gene expression of proinflammatory cytokines and growth factors in a rat model of benign prostatic hyperplasia. Rick FG, etal., Prostate. 2011 May 15;71(7):736-47. doi: 10.1002/pros.21289. Epub 2010 Oct 13.
23. Keratinocytes play a role in the immunity to Herpes simplex virus type 2 infection. Shao Y, etal., Acta Virol. 2010;54(4):261-7.
24. Altered expression of genes involved in inflammation and apoptosis in frontal cortex in major depression. Shelton RC, etal., Mol Psychiatry. 2011 Jul;16(7):751-62. doi: 10.1038/mp.2010.52. Epub 2010 May 18.
25. Plasma protein profiling reveals protein clusters related to BMI and insulin levels in middle-aged overweight subjects. van Dijk SJ, etal., PLoS One. 2010 Dec 23;5(12):e14422.
26. Human fatal zaire ebola virus infection is associated with an aberrant innate immunity and with massive lymphocyte apoptosis. Wauquier N, etal., PLoS Negl Trop Dis. 2010 Oct 5;4(10). pii: e837.
27. Differential cytokine secretion of cultured bone marrow stromal cells from patients with psoriasis and healthy volunteers. Zhang K, etal., Eur J Dermatol. 2010 Jan-Feb;20(1):49-53. Epub 2009 Nov 4.
28. Association analysis of polymorphisms in IL-3, IL-4, IL-5, IL-9, and IL-13 with Graves' disease. Zhu W, etal., J Endocrinol Invest. 2010 Nov;33(10):751-5. Epub 2010 Mar 22.
Additional References at PubMed
PMID:1319776   PMID:1327283   PMID:1346798   PMID:1347472   PMID:1349581   PMID:1350248   PMID:1358285   PMID:1372640   PMID:1375116   PMID:1445902   PMID:1533386   PMID:1571554  
PMID:1643309   PMID:1649220   PMID:1676978   PMID:1794055   PMID:1794058   PMID:1848528   PMID:1889803   PMID:1969921   PMID:2013230   PMID:2413359   PMID:2466396   PMID:2563351  
PMID:2567264   PMID:2676840   PMID:2784591   PMID:2789124   PMID:2851124   PMID:2882472   PMID:2890503   PMID:2902144   PMID:2990035   PMID:3016667   PMID:3034600   PMID:3494779  
PMID:3918308   PMID:3920001   PMID:3926497   PMID:3935516   PMID:6322187   PMID:6420702   PMID:6575777   PMID:6815268   PMID:7498529   PMID:7507352   PMID:7515712   PMID:7519644  
PMID:7519779   PMID:7522247   PMID:7536488   PMID:7536685   PMID:7537213   PMID:7538533   PMID:7557449   PMID:7559381   PMID:7590745   PMID:7594523   PMID:7602099   PMID:7626895  
PMID:7651724   PMID:7690439   PMID:7690814   PMID:7691943   PMID:7713516   PMID:7715825   PMID:7734624   PMID:7736574   PMID:7760829   PMID:7767000   PMID:7829087   PMID:7873878  
PMID:7932787   PMID:7957045   PMID:8045595   PMID:8099936   PMID:8103600   PMID:8138038   PMID:8199405   PMID:8207122   PMID:8378315   PMID:8389625   PMID:8406478   PMID:8449498  
PMID:8464923   PMID:8499630   PMID:8570653   PMID:8617885   PMID:8683100   PMID:8702776   PMID:8770556   PMID:8839836   PMID:8871607   PMID:8875898   PMID:8921409   PMID:8934515  
PMID:9070927   PMID:9098403   PMID:9110989   PMID:9180904   PMID:9202146   PMID:9294616   PMID:9324293   PMID:9327738   PMID:9344502   PMID:9446636   PMID:9457670   PMID:9479488  
PMID:9510253   PMID:9531584   PMID:9582023   PMID:9610912   PMID:9697835   PMID:9806848   PMID:9808576   PMID:10349636   PMID:10359848   PMID:10450743   PMID:10464288   PMID:10652277  
PMID:10655497   PMID:10704283   PMID:10872802   PMID:10943842   PMID:11042159   PMID:11076861   PMID:11159518   PMID:11217851   PMID:11409899   PMID:11527400   PMID:11886176   PMID:11895800  
PMID:12115609   PMID:12124386   PMID:12220225   PMID:12228733   PMID:12393460   PMID:12393611   PMID:12466851   PMID:12477932   PMID:12714518   PMID:12732663   PMID:12816992   PMID:12869574  
PMID:12944463   PMID:12954615   PMID:12960281   PMID:14684749   PMID:14967141   PMID:15060062   PMID:15231831   PMID:15259023   PMID:15542585   PMID:15647285   PMID:15680329   PMID:15878977  
PMID:15905544   PMID:15947484   PMID:16141072   PMID:16141073   PMID:16204634   PMID:16371368   PMID:16455967   PMID:16705087   PMID:16890157   PMID:16894356   PMID:16920984   PMID:17027084  
PMID:17035062   PMID:17437992   PMID:17446165   PMID:17483299   PMID:17511959   PMID:17557120   PMID:17915029   PMID:17942981   PMID:18322235   PMID:18460645   PMID:18487512   PMID:18586679  
PMID:18632726   PMID:18775989   PMID:18975389   PMID:19109167   PMID:19109256   PMID:19124748   PMID:19234178   PMID:19282460   PMID:19465908   PMID:19710468   PMID:19829692   PMID:19965665  
PMID:20007140   PMID:20038645   PMID:20472554   PMID:20516062   PMID:20686126   PMID:20691668   PMID:20711995   PMID:21044800   PMID:21242512   PMID:21262803   PMID:21267068   PMID:21329364  
PMID:21368889   PMID:21383156   PMID:21506110   PMID:21664343   PMID:21831442   PMID:22068549   PMID:22242014   PMID:22348085   PMID:22370606   PMID:22682244   PMID:22930820   PMID:23248281  
PMID:23261831   PMID:23520506   PMID:23528808   PMID:23603794   PMID:23683462   PMID:24103757   PMID:24194600   PMID:24284909   PMID:24367002   PMID:24379292   PMID:24598054   PMID:24633240  
PMID:24647110   PMID:24743235   PMID:24837103   PMID:25143363   PMID:25147341   PMID:25241746   PMID:25651939   PMID:25766237   PMID:25887124   PMID:25912172   PMID:26131743   PMID:26589916  
PMID:27485735   PMID:27581357   PMID:27723723   PMID:27734026   PMID:28039843   PMID:28096407   PMID:28426964   PMID:28573141   PMID:28606987   PMID:28965767   PMID:29523595   PMID:29777594  
PMID:29915594   PMID:30352428   PMID:30373540   PMID:30504915   PMID:30626747   PMID:30664659   PMID:30945313   PMID:30967512   PMID:31068389   PMID:31515941   PMID:33027513   PMID:33097708  
PMID:33427298   PMID:33541498   PMID:34262178   PMID:34571009   PMID:35075102   PMID:35281014   PMID:35563758   PMID:35707726  


Genomics

Comparative Map Data
Il3
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391154,155,911 - 54,158,105 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1154,156,129 - 54,158,103 (-)EnsemblGRCm39 Ensembl
GRCm381154,265,085 - 54,267,279 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1154,265,303 - 54,267,277 (-)EnsemblGRCm38mm10GRCm38
MGSCv371154,078,587 - 54,080,781 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv361154,108,726 - 54,110,700 (-)NCBIMGSCv36mm8
Celera1158,854,078 - 58,856,272 (-)NCBICelera
Cytogenetic Map11B1.3NCBI
cM Map1132.13NCBI
IL3
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385132,060,655 - 132,063,204 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl5132,060,655 - 132,063,204 (+)EnsemblGRCh38hg38GRCh38
GRCh375131,396,348 - 131,398,897 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,424,246 - 131,426,795 (+)NCBINCBI36Build 36hg18NCBI36
Build 345131,424,245 - 131,426,795NCBI
Celera5127,526,422 - 127,528,971 (+)NCBICelera
Cytogenetic Map5q31.1NCBI
HuRef5126,588,706 - 126,591,255 (+)NCBIHuRef
CHM1_15130,829,174 - 130,831,722 (+)NCBICHM1_1
T2T-CHM13v2.05132,580,524 - 132,583,073 (+)NCBIT2T-CHM13v2.0
Il3
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21038,405,716 - 38,408,066 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1038,405,716 - 38,408,066 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1043,090,254 - 43,092,770 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.01042,580,351 - 42,582,867 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.01038,084,063 - 38,086,579 (-)NCBIRnor_WKY
Rnor_6.01039,620,535 - 39,622,973 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1039,620,563 - 39,622,973 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01039,397,782 - 39,400,192 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41039,684,691 - 39,687,041 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11039,698,313 - 39,700,664 (-)NCBI
Celera1037,746,256 - 37,748,606 (-)NCBICelera
Cytogenetic Map10q22NCBI
IL3
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.15133,647,667 - 133,650,213 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl5133,647,667 - 133,650,213 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v05127,483,843 - 127,486,388 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
IL3
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.11120,330,480 - 20,332,668 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl1120,330,480 - 20,332,668 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha1119,126,033 - 19,128,221 (+)NCBIDog10K_Boxer_Tasha
UMICH_Zoey_3.11119,835,277 - 19,837,465 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.01119,683,253 - 19,685,440 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.01120,324,838 - 20,327,026 (+)NCBIUU_Cfam_GSD_1.0
Il3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024407213116,100,160 - 116,101,996 (-)NCBIHiC_Itri_2
SpeTri2.0NW_0049366473,102,922 - 3,104,758 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
IL3
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.12334,894,630 - 34,899,105 (+)NCBIChlSab1.1ChlSab1.1chlSab2
Vero_WHO_p1.0NW_02366603443,059,393 - 43,061,627 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:110
Count of miRNA genes:105
Interacting mature miRNAs:110
Transcripts:ENSMUST00000019058
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
27226798Scvln18_msacral vertebrae length 2, 16 week (mouse)11325000060690826Mouse
26884446Sklq10_mskull length QTL 10, 10 week (mouse)11325000062890826Mouse
26884453Sklq16_mskull length QTL 16, 16 week (mouse)11325000072690826Mouse
13208559Wght10_mweight 10 (mouse)11395000088890826Mouse
13208558Lgth12_mbody length 12 (mouse)11395000094890826Mouse
1300905Scc6_mcolon tumor susceptibility 6 (mouse)Not determined11688027789019734Mouse
27226738Metcl11_mmetatarsal-calcaneal length 11, 10 week (mouse)11885000061390826Mouse
26884401Huml4_mhumerus length 4, 10 week (mouse)111155000068490826Mouse
27226762Feml21_mfemur length 21, 16 week (mouse)111175000065990826Mouse
1357640Orq2_movulation rate QTL 2 (mouse)Not determined111226863768500330Mouse
4141127W3q4_mweight 3 weeks QTL 4 (mouse)Not determined1226863768500330Mouse
4141470Egq4_mearly growth QTL 4 (mouse)Not determined1226863768500330Mouse
4142109W10q2_mweight 10 weeks QTL 2 (mouse)Not determined1226863768500330Mouse
4141582Lgaq1_mlate growth adjusted QTL 1 (mouse)Not determined1226863768500330Mouse
4142308W6q3_mweight 6 weeks QTL 3 (mouse)Not determined111226863768500330Mouse
4142216Lgq1_mlate growth QTL 1 (mouse)Not determined1226863768500330Mouse
4141966Tailq1_mtail length QTL 1 (mouse)Not determined1226863768500330Mouse
1357851Scfq3_msubcutaneous fat pad weight QTL 3 (mouse)Not determined111226863768500330Mouse
1357720Kidpq1_mkidney weight percentage QTL 1 (mouse)Not determined111226863768500330Mouse
1357437Epfq4_mepididymal fat pad weight QTL 4 (mouse)Not determined111226863768500330Mouse
1559002Lmrq4_mLeishmania major resistance QTL 4 (mouse)Not determined111226863769684947Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112268637118022724Mouse
1558945Orgwq8_morgan weight QTL 8 (mouse)Not determined111705617567078411Mouse
10053687Eae6_msusceptibility to experimental allergic encephalomyelitis 6 (mouse)Not determined111778196668500330Mouse
4141894Nidd6k_mNidd6 on KK-A (mouse)Not determined1912420496897826Mouse
4141398Tgq22_mtriglyceride QTL 22 (mouse)Not determined2116340655163406Mouse
10412246Dfs2_mdental fluorosis suseptibility 2 (mouse)Not determined112180736495881231Mouse
10044006Hbnr13_mHeligmosomoides bakeri nematode resistance 13 (mouse)Not determined112577262659772741Mouse
1357844Si5lq5_mserum IGFBP-5 level QTL 5 (mouse)Not determined112816587362165976Mouse
13524848Ppiq7_mprepulse inhibition QTL 7 (mouse)112856914762569147Mouse
1301426Desp2_mdespair 2 (mouse)Not determined112870858162708700Mouse
11522752Cocia18_mcocaine-induced activity, QTL 18 (mouse)113100820965008209Mouse
11059563Lmr31_mleishmaniasis resistance 31 (mouse)113210057766100694Mouse
1357782Char8_mP. chabaudi malaria resistance QTL 8 (mouse)Not determined113557861669684987Mouse
13208569Bmiq10_mbody mass index QTL 10 (mouse)113589082784890826Mouse
1301328Mol4_mmodifier of LPS-response 4 (mouse)Not determined113628257783481356Mouse
1301788Lbw8_mlupus NZB x NZW 8 (mouse)Not determined113650328770509492Mouse
1301896Tria1_mT-cell receptor induced activation 1 (mouse)Not determined113661356570613855Mouse
4141853Skmw17_mskeletal muscle weight 17 (mouse)Not determined113708094171081064Mouse
4142475Ity2a_mimmunity to S. typhimurium 2a (mouse)Not determined113776858060402716Mouse
10766457Nwa3_mNew Zealand White autoimmunity 3 (mouse)113801611572016209Mouse
11532698Sluc36a_msusceptibility to lung cancer 36a (mouse)114225661776256730Mouse
11532699Sluc36b_msusceptibility to lung cancer 36b (mouse)114225661776256730Mouse
4142300Ctrq3_mC. trachomatis resistance QTL 3 (mouse)Not determined114463003876854757Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44630038113058009Mouse
1302021Nidd1n_mnon-insulin-dependent diabetes mellitus 1 in NSY (mouse)Not determined114516587379978324Mouse
1357878Mastr_mmodifier of astrocytoma (mouse)Not determined114570858189818733Mouse
1300765Bbaa4_mB.burgdorferi-associated arthritis 4 (mouse)Not determined114618516780185262Mouse
1301988Bmd11_mbone mineral density 11 (mouse)Not determined114631940780319522Mouse
1301830Ssta4_msusceptibility to Salmonella typhimurium antigens 4 (mouse)Not determined115007819184078411Mouse
13524840Ppiq9a_mprepulse inhibition QTL 9a (mouse)115249438586494385Mouse
1300774Pgia7_mproteoglycan induced arthritis 7 (mouse)Not determined115339058887390737Mouse
4141084Spqq1_msperm quality QTL 1 (mouse)Not determined5406567063319522Mouse
1302186Blmpf2_mbleomycin-induced pulmonary fibrosis 2 (mouse)Not determined115406567067078411Mouse
4142148Ckdbp2_mchronic kidney disease blood pressure locus 2 (mouse)Not determined115408094165103841Mouse
4141830Pregq1_mpregnancy QTL 1 (mouse)Not determined115412675283733652Mouse

Markers in Region
K03233  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,265,107 - 54,265,288UniSTSGRCm38
MGSCv371154,078,609 - 54,078,790UniSTSGRCm37
Celera1158,854,100 - 58,854,281UniSTS
Cytogenetic Map11B1UniSTS
cM Map1128.5UniSTS
Whitehead_YAC11 UniSTS
PMC126184P1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,265,102 - 54,265,360UniSTSGRCm38
MGSCv371154,078,604 - 54,078,862UniSTSGRCm37
Celera1158,854,095 - 58,854,353UniSTS
Cytogenetic Map11B1UniSTS
cM Map1128.5UniSTS
Il3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
MGSCv371154,079,439 - 54,079,680UniSTSGRCm37
Celera1158,854,930 - 58,855,171UniSTS
Cytogenetic Map11B1UniSTS
cM Map1128.5UniSTS
cM Map1128.5UniSTS
cM Map1128.5UniSTS
Il3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
Cytogenetic Map11B1UniSTS
cM Map1128.5UniSTS
Il3  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm381154,265,937 - 54,266,178UniSTSGRCm38
MGSCv371154,079,439 - 54,079,680UniSTSGRCm37
Celera1158,854,930 - 58,855,171UniSTS
Cytogenetic Map11B1UniSTS
cM Map1128.5UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_010556 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide A02046 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AF147878 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AH001974 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153634 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL596103 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125552 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC125554 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  D63767 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ788721 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  FB507175 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  HH829830 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01668 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K01850 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  K03233 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X02732 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000019058   ⟹   ENSMUSP00000019058
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl1154,156,129 - 54,158,103 (-)Ensembl
GRCm38.p6 Ensembl1154,265,303 - 54,267,277 (-)Ensembl
RefSeq Acc Id: NM_010556   ⟹   NP_034686
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm391154,155,911 - 54,158,105 (-)NCBI
GRCm381154,265,085 - 54,267,279 (-)ENTREZGENE
MGSCv371154,078,587 - 54,080,781 (-)RGD
Celera1158,854,078 - 58,856,272 (-)RGD
cM Map11 ENTREZGENE
Sequence:
Reference Sequences
RefSeq Acc Id: NP_034686   ⟸   NM_010556
- Peptide Label: precursor
- UniProtKB: P01586 (UniProtKB/Swiss-Prot),   Q5SX77 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000019058   ⟸   ENSMUST00000019058

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P01586-F1-model_v2 AlphaFold P01586 1-166 view protein structure

Promoters
RGD ID:6850120
Promoter ID:EP14064
Type:single initiation site
Name:MM_IL3
Description:Interleukin-3, multi-colony stimulating factor, IL3 or IL-3or CSFMU gene.
SO ACC ID:SO:0000170
Source:EPD (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Notes:homology_group=Homology group 48; Mammalian interleukin-3
Experiment Methods:Sequencing of a full-length cDNA
Regulation:lymphocytes; (induced by or strongly expressed in) antigen, (induced by or strongly expressed in) mitogen
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv371154,080,779 - 54,080,839EPD
MGSCv361154,080,779 - 54,080,839EPD
RGD ID:8674650
Promoter ID:EPDNEW_M15356
Type:single initiation site
Name:Il3_1
Description:Mus musculus interleukin 3 , mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm381154,267,278 - 54,267,338EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:96552 AgrOrtholog
Ensembl Genes ENSMUSG00000018914 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Protein ENSMUSP00000019058 ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000019058 ENTREZGENE, UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1250.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro 4_helix_cytokine-like_core UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IL-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:16187 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:96552 ENTREZGENE
NCBI Gene 16187 ENTREZGENE
Pfam IL3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Il3 PhenoGen
PIRSF IL-3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PRINTS INTERLEUKIN3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF47266 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
UniProt IL3_MOUSE UniProtKB/Swiss-Prot, ENTREZGENE
  Q0PMN2_MOUSE UniProtKB/TrEMBL
  Q5SX77 ENTREZGENE, UniProtKB/TrEMBL