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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:aminoquinoline
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Accession:CHEBI:36709 term browser browse the term
Definition:Any member of the class of quinolines in which the quinoline skeleton is substituted by one or more amino or substituted-amino groups.
Synonyms:related_synonym: aminoquinolines



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2,3,5,6,7,8-hexahydro-1H-cyclopenta[b]quinolin-9-amine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase decreases activity ISO amiridine results in decreased activity of ACHE protein CTD PMID:9228650 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bche butyrylcholinesterase decreases activity ISO amiridine results in decreased activity of BCHE protein CTD PMID:9228650 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
6-anilino-5,8-quinolinedione term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression
ISO 6-anilino-5,8-quinolinedione inhibits the reaction [sodium bichromate results in increased ubiquitination of BCL2 protein]
6-anilino-5,8-quinolinedione results in decreased expression of BCL2 protein
CTD PMID:18544562 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bdnf brain-derived neurotrophic factor decreases response to substance ISO BDNF protein results in decreased susceptibility to 6-anilino-5,8-quinolinedione CTD PMID:22261313 NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
JBrowse link
G Hsp90aa1 heat shock protein 90 alpha family class A member 1 multiple interactions EXP 6-anilino-5,8-quinolinedione results in increased expression of and results in increased secretion of HSP90AA1 protein CTD PMID:10617604 NCBI chr 6:129,702,376...129,707,907
Ensembl chr 6:129,702,383...129,707,268
JBrowse link
G Hsp90ab1 heat shock protein 90 alpha family class B member 1 increases expression EXP 6-anilino-5,8-quinolinedione results in increased expression of HSP90AB1 protein CTD PMID:10617604 NCBI chr 9:15,432,986...15,438,358
Ensembl chr 9:15,433,691...15,438,488
JBrowse link
G Il4 interleukin 4 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL4 protein CTD PMID:16533816 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il5 interleukin 5 decreases secretion ISO 6-anilino-5,8-quinolinedione results in decreased secretion of IL5 protein CTD PMID:16533816 NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
JBrowse link
G Vegfa vascular endothelial growth factor A multiple interactions ISO 6-anilino-5,8-quinolinedione inhibits the reaction [heat stable toxin (E coli) results in decreased expression of VEGFA protein] CTD PMID:17828804 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
JBrowse link
amodiaquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions ISO Amodiaquine analog inhibits the reaction [Paraoxon results in decreased activity of ACHE protein]; Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of ACHE protein] CTD PMID:29614332 NCBI chr12:19,407,359...19,413,713
Ensembl chr12:19,407,360...19,413,651
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression
ISO [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein
Amodiaquine results in increased expression of BAX protein
CTD PMID:31629065 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bche butyrylcholinesterase multiple interactions ISO Amodiaquine inhibits the reaction [Paraoxon results in decreased activity of BCHE protein] CTD PMID:29614332 NCBI chr 2:158,308,674...158,401,148
Ensembl chr 2:158,307,584...158,401,148
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression
multiple interactions
ISO Amodiaquine results in decreased expression of BCL2 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein
CTD PMID:31629065 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bmp6 bone morphogenetic protein 6 increases expression ISO Amodiaquine results in increased expression of BMP6 mRNA CTD PMID:32816093 NCBI chr17:26,318,121...26,469,034
Ensembl chr17:26,318,569...26,470,365
JBrowse link
G Casp3 caspase 3 increases cleavage ISO Amodiaquine results in increased cleavage of CASP3 protein CTD PMID:31629065 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Ccnd1 cyclin D1 affects expression ISO Amodiaquine affects the expression of CCND1 protein CTD PMID:24113242 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A affects expression ISO Amodiaquine affects the expression of CDKN1A mRNA; Amodiaquine affects the expression of CDKN1A protein CTD PMID:24113242 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Ctla4 cytotoxic T-lymphocyte-associated protein 4 multiple interactions ISO CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]] CTD PMID:29938495 NCBI chr 9:62,318,874...62,325,978
Ensembl chr 9:62,319,312...62,324,963
JBrowse link
G Ctsb cathepsin B decreases activity ISO Amodiaquine results in decreased activity of CTSB protein CTD PMID:24113242 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D decreases activity ISO Amodiaquine results in decreased activity of CTSD protein CTD PMID:24113242 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L decreases activity ISO Amodiaquine results in decreased activity of CTSL protein CTD PMID:24113242 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases activity
multiple interactions
decreases response to substance
increases metabolic processing
ISO Amodiaquine results in increased activity of CYP1A1 protein
[CYP1A1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CYP1A1 protein results in decreased susceptibility to Amodiaquine
CTD PMID:12451431 PMID:31629065 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity
increases metabolic processing
multiple interactions
ISO Amodiaquine results in decreased activity of CYP1A2 protein
CYP1A2 protein results in increased metabolism of Amodiaquine
[CYP1A2 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [Gemfibrozil results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine; [Trimethoprim results in decreased activity of CYP1A2 protein] which results in decreased metabolism of Amodiaquine
CTD PMID:11124226 PMID:26599973 PMID:31629065 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases response to substance
increases metabolic processing
multiple interactions
ISO CYP1B1 protein results in decreased susceptibility to Amodiaquine
CYP1B1 protein results in increased metabolism of Amodiaquine
[CYP1B1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Cyp2a1 cytochrome P450, family 2, subfamily a, polypeptide 1 increases metabolic processing
multiple interactions
ISO CYP2A13 protein results in increased metabolism of Amodiaquine
[CYP2A13 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 1:82,231,611...82,244,887
Ensembl chr 1:82,231,611...82,244,887
JBrowse link
G Cyp2b3 cytochrome P450, family 2, subfamily b, polypeptide 3 multiple interactions
increases metabolic processing
ISO [CYP2B6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr 1:81,652,762...81,732,153
Ensembl chr 1:81,652,787...81,732,143
JBrowse link
G Cyp2c24 cytochrome P450, family 2, subfamily c, polypeptide 24 increases metabolic processing
multiple interactions
ISO CYP2C18 protein results in increased metabolism of Amodiaquine
[CYP2C18 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity
increases metabolic processing
multiple interactions
ISO Amodiaquine results in decreased activity of CYP2C19 protein
CYP2C19 protein results in increased metabolism of Amodiaquine
[CYP2C19 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:11124226 PMID:31629065 NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions
increases response to substance
increases metabolic processing
affects metabolic processing
ISO [5-bromotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-chlorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [5-fluorotryptamine analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP2C8 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of desethylamodiaquine; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Gemfibrozil co-treated with Amodiaquine] results in decreased activity of CYP2C8 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; [Tryptamines analog results in decreased activity of CYP2C8 protein] which results in decreased metabolism of Amodiaquine; Felodipine inhibits the reaction [CYP2C8 protein results in increased metabolism of Amodiaquine]; Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]
CYP2C8 protein affects the metabolism of Amodiaquine
CTD PMID:12920490 PMID:15155557 PMID:15601807 PMID:15626586 PMID:15771232 More...
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 increases metabolic processing
multiple interactions
ISO CYP2D6 protein results in increased metabolism of Amodiaquine
[CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine; [CYP2D6 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine
CTD PMID:28478157 PMID:31629065 PMID:33259822 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions
increases metabolic processing
ISO [CYP2E1 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine CTD PMID:31629065 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing
increases response to substance
ISO [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased abundance of and results in increased secretion of desethylamodiaquine; [CYP3A4 protein results in increased metabolism of Amodiaquine] which results in increased chemical synthesis of amodiaquine quinoneimine; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of BCL2 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in increased expression of BAX protein; Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine] CTD PMID:28478157 PMID:31629065 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases metabolic processing
multiple interactions
ISO CYP3A5 protein results in increased metabolism of Amodiaquine
[CYP3A5 protein results in increased metabolism of Amodiaquine] which results in increased abundance of desethylamodiaquine
CTD PMID:31629065 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
JBrowse link
G E2f1 E2F transcription factor 1 affects expression ISO Amodiaquine affects the expression of E2F1 mRNA; Amodiaquine affects the expression of E2F1 protein CTD PMID:24113242 NCBI chr 3:143,064,535...143,075,362
Ensembl chr 3:143,049,478...143,075,361
JBrowse link
G Ereg epiregulin increases expression ISO Amodiaquine results in increased expression of EREG mRNA CTD PMID:32816093 NCBI chr14:17,027,287...17,041,062
Ensembl chr14:17,027,287...17,041,062
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Il1a interleukin 1 alpha decreases expression ISO Amodiaquine results in decreased expression of IL1A mRNA CTD PMID:32816093 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Lag3 lymphocyte activating 3 multiple interactions ISO [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein] CTD PMID:29938495 NCBI chr 4:157,712,665...157,722,229
Ensembl chr 4:157,712,667...157,720,404
JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions ISO [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK1 protein CTD PMID:31629065 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions ISO [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK3 protein CTD PMID:31629065 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO [CYP2C8 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein; [CYP3A4 protein results in increased susceptibility to Amodiaquine] which results in increased phosphorylation of MAPK8 protein CTD PMID:31629065 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions
ISO Amodiaquine results in decreased expression of MCL1 protein
[Ketoconazole inhibits the reaction [CYP3A4 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein; [Rifampin inhibits the reaction [CYP2C8 protein results in increased susceptibility to Amodiaquine]] which results in decreased expression of MCL1 protein
CTD PMID:31629065 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Met MET proto-oncogene, receptor tyrosine kinase increases expression ISO Amodiaquine results in increased expression of MET mRNA CTD PMID:32816093 NCBI chr 4:45,790,456...45,898,139
Ensembl chr 4:45,790,791...45,897,876
JBrowse link
G Mpo myeloperoxidase affects response to substance ISO MPO protein affects the susceptibility to Amodiaquine CTD PMID:24588327 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Amodiaquine inhibits the reaction [NQO2 protein results in increased reduction of Vitamin K 3] CTD PMID:29281794 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Amodiaquine binds to and results in increased activity of NR4A2 protein CTD PMID:31175960 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Pdcd1 programmed cell death 1 multiple interactions ISO [PDCD1 protein co-treated with LAG3 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]; CTLA4 protein affects the reaction [PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]]]; PDCD1 protein affects the reaction [[LY6C1 protein co-treated with LY6G protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 9:94,418,786...94,431,945
Ensembl chr 9:94,418,791...94,431,937
JBrowse link
G Pid1 phosphotyrosine interaction domain containing 1 increases expression ISO Amodiaquine results in increased expression of PID1 mRNA CTD PMID:32816093 NCBI chr 9:85,284,335...85,503,035
Ensembl chr 9:85,284,335...85,503,044
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases expression ISO Amodiaquine results in decreased expression of PTGS2 mRNA CTD PMID:32816093 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rb1 RB transcriptional corepressor 1 affects phosphorylation ISO Amodiaquine affects the phosphorylation of RB1 protein CTD PMID:24113242 NCBI chr15:48,371,295...48,502,473
Ensembl chr15:48,371,296...48,502,302
JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO [PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]; CTLA4 protein affects the reaction [[PDCD1 protein co-treated with TGFB1 protein] affects the reaction [Amodiaquine results in increased expression of GPT protein]] CTD PMID:29938495 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tnfaip6 TNF alpha induced protein 6 decreases expression ISO Amodiaquine results in decreased expression of TNFAIP6 mRNA CTD PMID:32816093 NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
JBrowse link
G Tp53 tumor protein p53 increases activity
affects expression
ISO Amodiaquine results in increased activity of TP53 protein
Amodiaquine affects the expression of TP53 protein
CTD PMID:12082016 PMID:24113242 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
bosutinib term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abl1 ABL proto-oncogene 1, non-receptor tyrosine kinase decreases activity ISO bosutinib results in decreased activity of ABL1 protein CTD PMID:17114238 NCBI chr 3:14,979,853...15,083,065
Ensembl chr 3:14,979,853...15,083,065
JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
decreases expression
ISO bosutinib results in decreased phosphorylation of AKT1 protein
bosutinib results in decreased expression of AKT1 protein
CTD PMID:17129604 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Ccnd1 cyclin D1 decreases expression
multiple interactions
ISO bosutinib results in decreased expression of CCND1 protein
[SM 164 co-treated with bosutinib] results in decreased expression of CCND1 protein
CTD PMID:16489032 PMID:22241084 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
JBrowse link
G Ccnd3 cyclin D3 affects localization
multiple interactions
ISO bosutinib affects the localization of CCND3 protein
[bosutinib co-treated with Imatinib Mesylate] affects the localization of CCND3 protein
CTD PMID:17129604 NCBI chr 9:13,394,161...13,400,341
Ensembl chr 9:13,394,169...13,489,371
JBrowse link
G Cdc25a cell division cycle 25A decreases expression
multiple interactions
ISO bosutinib results in decreased expression of CDC25A protein
Imatinib Mesylate promotes the reaction [bosutinib results in decreased expression of CDC25A protein]
CTD PMID:17129604 NCBI chr 8:109,864,356...109,882,734
Ensembl chr 8:109,864,478...109,882,701
JBrowse link
G Cdh1 cadherin 1 multiple interactions ISO bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein] CTD PMID:16489032 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases activity
decreases expression
ISO bosutinib results in decreased activity of CDK2 protein
bosutinib results in decreased expression of CDK2 protein
CTD PMID:17129604 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO bosutinib results in increased expression of CDKN1A protein CTD PMID:17129604 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression
multiple interactions
ISO bosutinib results in increased expression of CDKN1B protein
Imatinib Mesylate promotes the reaction [bosutinib results in increased expression of CDKN1B protein]
CTD PMID:17129604 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Csk C-terminal Src kinase decreases activity EXP bosutinib results in decreased activity of CSK protein CTD PMID:17114238 NCBI chr 8:58,029,748...58,048,742
Ensembl chr 8:58,029,749...58,048,292
JBrowse link
G Ctnnb1 catenin beta 1 affects localization
decreases phosphorylation
multiple interactions
ISO bosutinib affects the localization of CTNNB1 protein
bosutinib results in decreased phosphorylation of CTNNB1 protein
bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein]; bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]; bosutinib promotes the reaction [CTNNB1 protein binds to CDH1 protein]; CTNNB1 protein promotes the reaction [bosutinib results in increased stability of CDH1 protein]
CTD PMID:16489032 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Egfr epidermal growth factor receptor decreases activity ISO bosutinib results in decreased activity of EGFR protein CTD PMID:18385429 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases phosphorylation EXP bosutinib results in decreased phosphorylation of ERBB2 protein CTD PMID:18385429 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Fgr FGR proto-oncogene, Src family tyrosine kinase decreases activity EXP bosutinib results in decreased activity of FGR protein CTD PMID:17114238 NCBI chr 5:145,189,814...145,219,571
Ensembl chr 5:145,189,841...145,217,326
JBrowse link
G Gpt glutamic--pyruvic transaminase increases secretion ISO bosutinib results in increased secretion of GPT protein CTD PMID:29655783 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Lyn LYN proto-oncogene, Src family tyrosine kinase decreases activity EXP bosutinib results in decreased activity of LYN protein CTD PMID:17114238 NCBI chr 5:16,639,512...16,755,501
Ensembl chr 5:16,639,466...16,756,868
JBrowse link
G Slc16a2 solute carrier family 16 member 2 multiple interactions ISO bosutinib inhibits the reaction [SLC16A2 protein results in increased uptake of Triiodothyronine] CTD PMID:28119167 NCBI chr  X:68,725,365...68,848,572
Ensembl chr  X:68,723,261...68,848,771
JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase decreases phosphorylation
multiple interactions
ISO bosutinib results in decreased phosphorylation of SRC protein
bosutinib inhibits the reaction [SRC protein results in increased phosphorylation of CTNNB1 protein]
CTD PMID:16489032 NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
JBrowse link
G Tcf4 transcription factor 4 multiple interactions ISO bosutinib inhibits the reaction [CTNNB1 protein binds to TCF4 protein] CTD PMID:16489032 NCBI chr18:62,941,739...63,288,126
Ensembl chr18:62,943,782...63,284,425
JBrowse link
chloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of ABCB1 mRNA; Chloroquine results in decreased expression of ABCB1 protein
Chloroquine results in decreased expression of ABCB1A mRNA
[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein; Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1A mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1A mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1A protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]
Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1 mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein
CTD PMID:25987058 PMID:27692344 PMID:30482226 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases expression ISO Chloroquine results in decreased expression of ABCC1 mRNA; Chloroquine results in decreased expression of ABCC1 protein CTD PMID:27692344 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Chloroquine results in decreased expression of ABCC2 mRNA; Chloroquine results in decreased expression of ABCC2 protein CTD PMID:27692344 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 decreases expression ISO Chloroquine results in decreased expression of ABCG2 mRNA; Chloroquine results in decreased expression of ABCG2 protein CTD PMID:27692344 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions
decreases phosphorylation
ISO
EXP
Chloroquine affects the reaction [Cannabidiol results in decreased phosphorylation of AKT1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of AKT1 protein]
Chloroquine results in decreased phosphorylation of AKT1 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein]
CTD PMID:24990399 PMID:27180204 PMID:32060308 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Akt1s1 AKT1 substrate 1 multiple interactions EXP Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein] CTD PMID:22689575 NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
JBrowse link
G Aldh1b1 aldehyde dehydrogenase 1 family, member B1 decreases expression EXP Chloroquine results in decreased expression of ALDH1B1 mRNA CTD PMID:19393257 NCBI chr 5:60,063,370...60,068,378
Ensembl chr 5:60,063,225...60,068,378
JBrowse link
G Angptl8 angiopoietin-like 8 multiple interactions ISO Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
JBrowse link
G Apod apolipoprotein D affects localization ISO Chloroquine affects the localization of APOD protein CTD PMID:28182653 NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
JBrowse link
G Apoe apolipoprotein E affects localization EXP Chloroquine affects the localization of APOE protein CTD PMID:8616629 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
JBrowse link
G App amyloid beta precursor protein affects expression
multiple interactions
affects localization
increases expression
EXP Chloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP protein
Chloroquine affects the localization of and affects the cleavage of APP protein
Chloroquine affects the localization of APP protein
Chloroquine results in increased expression of APP protein
CTD PMID:7715800 PMID:8616629 PMID:8787835 PMID:9690670 NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
JBrowse link
G Appl1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 multiple interactions ISO Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein] CTD PMID:25780039 NCBI chr16:2,118,503...2,166,741
Ensembl chr16:2,121,255...2,166,692
JBrowse link
G Aqp2 aquaporin 2 decreases degradation
multiple interactions
decreases expression
ISO Chloroquine results in decreased degradation of AQP2 protein
Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]
Chloroquine results in decreased expression of AQP2 protein
CTD PMID:21734099 PMID:22791344 NCBI chr 7:130,711,433...130,716,468
Ensembl chr 7:130,711,413...130,716,468
JBrowse link
G Aqp5 aquaporin 5 multiple interactions ISO Chloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein] CTD PMID:15536076 NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
JBrowse link
G Ar androgen receptor multiple interactions ISO Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein] CTD PMID:30280407 NCBI chr  X:63,104,771...63,273,934
Ensembl chr  X:63,104,771...63,273,925
JBrowse link
G Arcn1 archain 1 affects localization ISO Chloroquine affects the localization of ARCN1 protein CTD PMID:29940786 NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Chloroquine results in decreased expression of ASS1 mRNA CTD PMID:19393257 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atf4 activating transcription factor 4 multiple interactions EXP Chloroquine promotes the reaction [cadmium acetate results in increased expression of ATF4 protein] CTD PMID:29870746 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atg5 autophagy related 5 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of ATG5 protein]
Chloroquine results in increased expression of ATG5 protein
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of ATG5 protein]
CTD PMID:28184909 PMID:29870746 PMID:30338810 NCBI chr20:47,798,222...47,889,216
Ensembl chr20:47,798,290...47,889,209
JBrowse link
G Atm ATM serine/threonine kinase increases phosphorylation ISO Chloroquine results in increased phosphorylation of ATM protein CTD PMID:18089834 NCBI chr 8:53,828,741...53,932,773
Ensembl chr 8:53,831,093...53,932,437
JBrowse link
G Atp1a1 ATPase Na+/K+ transporting subunit alpha 1 multiple interactions
increases expression
EXP
ISO
Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein]
Chloroquine results in increased expression of ATP1A1 protein
CTD PMID:10506578 PMID:26750564 NCBI chr 2:189,020,722...189,048,826
Ensembl chr 2:189,020,722...189,048,837
JBrowse link
G Avp arginine vasopressin multiple interactions ISO Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]; Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein] CTD PMID:22791344 NCBI chr 3:117,793,447...117,805,091
Ensembl chr 3:117,793,457...117,795,425
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO
EXP
BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]
Chloroquine affects the folding of and results in increased activity of BAX protein; Chloroquine inhibits the reaction [formosanin C results in increased expression of BAX protein]; Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein]
CTD PMID:11589424 PMID:23151917 PMID:27180204 PMID:28713934 PMID:33684387 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bbc3 Bcl-2 binding component 3 increases expression ISO Chloroquine results in increased expression of BBC3 mRNA CTD PMID:31310755 NCBI chr 1:77,013,281...77,022,509
Ensembl chr 1:77,014,543...77,022,509
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO
EXP
Chloroquine inhibits the reaction [formosanin C results in decreased expression of BCL2 protein]
Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]
CTD PMID:27180204 PMID:28713934 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions
increases expression
ISO BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine results in increased expression of BCL2L1 mRNA
CTD PMID:11589424 PMID:31310755 NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
JBrowse link
G Becn1 beclin 1 multiple interactions
decreases expression
ISO
EXP
Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cannabidiol results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cisplatin results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]
Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BECN1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in increased expression of BECN1 protein]
Chloroquine results in decreased expression of BECN1 mRNA; Chloroquine results in decreased expression of BECN1 protein
CTD PMID:25987058 PMID:27692344 PMID:28184909 PMID:29870746 PMID:31862506 More... NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA] CTD PMID:23111315 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Birc5 baculoviral IAP repeat-containing 5 multiple interactions ISO Chloroquine promotes the reaction [sunitinib results in decreased expression of BIRC5 protein]
Chloroquine promotes the reaction [Immunologic Factors results in decreased expression of BIRC5 protein]
CTD PMID:24751611 PMID:27823620 NCBI chr10:103,072,530...103,081,382
Ensembl chr10:103,073,408...103,081,380
JBrowse link
G Bnip3 BCL2 interacting protein 3 multiple interactions
increases expression
ISO vistusertib inhibits the reaction [Chloroquine results in increased expression of BNIP3 protein] CTD PMID:26853465 NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
JBrowse link
G Calr calreticulin increases expression
multiple interactions
ISO Chloroquine results in increased expression of CALR mRNA
[CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein; [Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Chloroquine results in increased expression of and affects the localization of CALR protein; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; Doxorubicin promotes the reaction [Chloroquine affects the localization of CALR protein]
[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]
CTD PMID:30482226 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Casp12 caspase 12 multiple interactions EXP Chloroquine promotes the reaction [cadmium acetate results in increased expression of CASP12 protein] CTD PMID:29870746 NCBI chr 8:2,642,296...2,669,549
Ensembl chr 8:2,642,434...2,674,037
JBrowse link
G Casp3 caspase 3 multiple interactions
increases cleavage
increases expression
increases activity
ISO
EXP
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein; [Rotenone co-treated with Chloroquine] results in increased cleavage of CASP3 protein; BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Chloroquine promotes the reaction [Sunitinib results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]
Chloroquine results in increased expression of CASP3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; [Chloroquine co-treated with N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine] results in increased activity of CASP3 protein; [vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cannabidiol results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [formosanin C results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]
CTD PMID:11589424 PMID:23151917 PMID:23799852 PMID:24751611 PMID:25078063 More... NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp7 caspase 7 multiple interactions ISO Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein] CTD PMID:25078063 NCBI chr 1:255,437,195...255,476,737
Ensembl chr 1:255,437,172...255,476,729
JBrowse link
G Casp8 caspase 8 increases cleavage
multiple interactions
ISO Chloroquine results in increased cleavage of CASP8 protein
Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP8 protein]
Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
CTD PMID:27692344 PMID:28906492 PMID:29111403 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 multiple interactions
increases cleavage
ISO [Chloroquine co-treated with N-(4-bromo-2-fluorophenyl)-6-methoxy-7-((1-methylpiperidin-4-yl)methoxy)quinazolin-4-amine] results in increased activity of CASP9 protein; Chloroquine inhibits the reaction [Cannabidiol results in increased cleavage of CASP9 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein] CTD PMID:23151917 PMID:23799852 PMID:28184909 PMID:28906492 PMID:32060308 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Casr calcium-sensing receptor multiple interactions EXP Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR protein] CTD PMID:32956540 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811
JBrowse link
G Cat catalase decreases activity
multiple interactions
decreases expression
EXP
ISO
Chloroquine results in decreased activity of CAT protein
Chloroquine promotes the reaction [sunitinib results in increased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of CAT mRNA]
Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]
Chloroquine results in decreased expression of CAT protein
CTD PMID:15526909 PMID:17076682 PMID:23607047 PMID:24751611 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Ccl1 C-C motif chemokine ligand 1 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL1 protein] CTD PMID:22341560 NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
JBrowse link
G Ccl11 C-C motif chemokine ligand 11 decreases secretion
multiple interactions
ISO Chloroquine results in decreased secretion of CCL11 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL11 protein]
CTD PMID:22341560 PMID:29772762 NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 increases expression
multiple interactions
decreases secretion
ISO Chloroquine results in increased expression of CCL2 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein]
Chloroquine results in decreased secretion of CCL2 protein
Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]
CTD PMID:15139008 PMID:22341560 PMID:29772762 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
JBrowse link
G Ccl25 C-C motif chemokine ligand 25 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein] CTD PMID:22341560 NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554
JBrowse link
G Ccl5 C-C motif chemokine ligand 5 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein] CTD PMID:22341560 NCBI chr10:68,322,826...68,327,365
Ensembl chr10:68,322,829...68,327,377
JBrowse link
G Ccn1 cellular communication network factor 1 increases expression EXP Chloroquine results in increased expression of CCN1 mRNA CTD PMID:19393257 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
JBrowse link
G Cd274 CD274 molecule decreases expression ISO Chloroquine results in decreased expression of CD274 protein CTD PMID:27692344 NCBI chr 1:227,116,627...227,137,379
Ensembl chr 1:227,116,649...227,134,450
JBrowse link
G Cd34 CD34 molecule multiple interactions ISO Chloroquine promotes the reaction [sunitinib results in decreased expression of CD34 protein] CTD PMID:24751611 NCBI chr13:106,480,074...106,499,462
Ensembl chr13:106,480,043...106,499,832
JBrowse link
G Cdh1 cadherin 1 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein] CTD PMID:30053495 NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
JBrowse link
G Cdh2 cadherin 2 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein] CTD PMID:30053495 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases activity
multiple interactions
increases expression
ISO Chloroquine results in increased activity of CDKN1A
[Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]
Chloroquine results in increased expression of CDKN1A protein
CTD PMID:12243503 PMID:18089834 PMID:22927544 PMID:30025493 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpb CCAAT/enhancer binding protein beta multiple interactions
increases expression
ISO 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
CTD PMID:30482226 NCBI chr 3:156,398,035...156,399,466
Ensembl chr 3:156,397,052...156,399,473
JBrowse link
G Chuk component of inhibitor of nuclear factor kappa B kinase complex decreases expression ISO Chloroquine results in decreased expression of CHUK protein CTD PMID:26116531 NCBI chr 1:242,959,539...242,995,066
Ensembl chr 1:242,959,760...242,995,065
JBrowse link
G Cip2a cellular inhibitor of PP2A multiple interactions ISO Chloroquine inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein] CTD PMID:24493623 NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
JBrowse link
G Cldn1 claudin 1 increases expression ISO Chloroquine results in increased expression of CLDN1 mRNA CTD PMID:25752684 NCBI chr11:74,421,569...74,436,728
Ensembl chr11:74,421,569...74,436,724
JBrowse link
G Cldn2 claudin 2 multiple interactions ISO Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein] CTD PMID:29597147 NCBI chr  X:103,459,870...103,473,794
Ensembl chr  X:103,459,780...103,474,838
JBrowse link
G Clu clusterin affects localization EXP Chloroquine affects the localization of CLU protein CTD PMID:8616629 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315
JBrowse link
G Coq6 coenzyme Q6 monooxygenase decreases expression EXP Chloroquine results in decreased expression of COQ6 mRNA CTD PMID:19393257 NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
JBrowse link
G Cox4i1 cytochrome c oxidase subunit 4i1 multiple interactions ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein] CTD PMID:30209975 NCBI chr19:48,721,680...48,727,920
Ensembl chr19:48,721,199...48,727,921
JBrowse link
G Cs citrate synthase multiple interactions ISO Chloroquine affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein] CTD PMID:33684387 NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA] CTD PMID:30053495 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
JBrowse link
G Ctsa cathepsin A multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSA protein CTD PMID:30821613 NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
JBrowse link
G Ctsb cathepsin B increases expression
decreases activity
multiple interactions
EXP
ISO
Chloroquine results in increased expression of CTSB protein
Chloroquine results in decreased activity of CTSB protein
[Chloroquine co-treated with dactolisib] affects the localization of CTSB protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein; Chloroquine inhibits the reaction [Arsenic Trioxide results in increased activity of CTSB protein]
CTD PMID:2759144 PMID:23151917 PMID:30338810 PMID:30821613 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500
JBrowse link
G Ctsd cathepsin D affects localization
multiple interactions
increases expression
EXP
ISO
Chloroquine affects the localization of CTSD protein
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSD protein
Chloroquine results in increased expression of CTSD protein
CTD PMID:2759144 PMID:7715800 PMID:30821613 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488
JBrowse link
G Ctsl cathepsin L increases expression EXP Chloroquine results in increased expression of CTSL protein CTD PMID:2759144 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548
JBrowse link
G Cxcl10 C-X-C motif chemokine ligand 10 multiple interactions ISO Chloroquine inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein] CTD PMID:26682054 NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
JBrowse link
G Cxcl12 C-X-C motif chemokine ligand 12 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein] CTD PMID:22341560 NCBI chr 4:150,388,326...150,401,173
Ensembl chr 4:150,388,325...150,401,168
JBrowse link
G Cxcl9 C-X-C motif chemokine ligand 9 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL9 protein] CTD PMID:22341560 NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
JBrowse link
G Cyp11a1 cytochrome P450, family 11, subfamily a, polypeptide 1 decreases expression EXP Chloroquine results in decreased expression of CYP11A1 mRNA CTD PMID:19393257 NCBI chr 8:58,422,807...58,434,342
Ensembl chr 8:58,404,669...58,434,338
JBrowse link
G Cyp17a1 cytochrome P450, family 17, subfamily a, polypeptide 1 decreases expression EXP Chloroquine results in decreased expression of CYP17A1 mRNA CTD PMID:19393257 NCBI chr 1:245,535,462...245,543,148
Ensembl chr 1:245,535,462...245,541,573
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine] CTD PMID:7946932 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 affects metabolic processing
multiple interactions
increases metabolic processing
ISO CYP2C8 polymorphism affects the metabolism of Chloroquine; CYP2C8 protein affects the metabolism of Chloroquine
[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]
CTD PMID:12756207 PMID:12920490 PMID:12967198 PMID:17286541 PMID:19560616
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 affects metabolic processing
decreases activity
multiple interactions
ISO CYP2D6 protein affects the metabolism of Chloroquine
Chloroquine results in decreased activity of CYP2D6 protein
[CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
CTD PMID:12756207 PMID:12920490 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
affects metabolic processing
decreases activity
ISO [CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
CYP3A4 protein affects the metabolism of Chloroquine
Chloroquine results in decreased activity of CYP3A4 protein
CTD PMID:11124226 PMID:12756207 PMID:12920490 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp7a1 cytochrome P450 family 7 subfamily A member 1 multiple interactions ISO Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form] CTD PMID:28275691 NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
JBrowse link
G Ddit3 DNA-damage inducible transcript 3 multiple interactions
increases expression
EXP
ISO
Chloroquine promotes the reaction [cadmium acetate results in increased expression of DDIT3 protein]; Chloroquine promotes the reaction [Cadmium results in increased expression of DDIT3 protein]
Chloroquine results in increased expression of DDIT3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; [Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]
CTD PMID:27658547 PMID:29870746 PMID:30482226 NCBI chr 7:63,115,645...63,121,203
Ensembl chr 7:63,116,380...63,121,201
JBrowse link
G Ddx3x DEAD-box helicase 3, X-linked multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein] CTD PMID:30821613 NCBI chr  X:9,479,532...9,493,455
Ensembl chr  X:9,479,532...9,493,168
JBrowse link
G Eea1 early endosome antigen 1 affects localization ISO Chloroquine affects the localization of EEA1 protein CTD PMID:29940786 NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
JBrowse link
G Egf epidermal growth factor multiple interactions ISO
EXP
Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]
Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
CTD PMID:20332299 PMID:22689575 NCBI chr 2:218,219,408...218,302,370
Ensembl chr 2:218,219,415...218,302,064
JBrowse link
G Egfr epidermal growth factor receptor multiple interactions
decreases expression
ISO
EXP
Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein]
Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
Chloroquine results in decreased expression of EGFR protein
CTD PMID:20056314 PMID:20332299 PMID:22457794 PMID:22689575 NCBI chr14:91,176,931...91,349,722
Ensembl chr14:91,177,067...91,344,382
JBrowse link
G Eif4a1 eukaryotic translation initiation factor 4A1 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein] CTD PMID:30821613 NCBI chr10:54,384,345...54,389,853
Ensembl chr10:54,384,347...54,389,858
JBrowse link
G Eif4ebp1 eukaryotic translation initiation factor 4E binding protein 1 multiple interactions EXP Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein] CTD PMID:22689575 NCBI chr16:64,792,595...64,805,984
Ensembl chr16:64,790,226...64,805,984
JBrowse link
G Eif4h eukaryotic translation initiation factor 4H multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein] CTD PMID:30821613 NCBI chr12:22,083,155...22,099,876
Ensembl chr12:22,082,835...22,099,876
JBrowse link
G Eno2 enolase 2 multiple interactions EXP Chloroquine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein] CTD PMID:26676567 NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
JBrowse link
G Erbb2 erb-b2 receptor tyrosine kinase 2 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of ERBB2 protein
Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]
CTD PMID:20056314 PMID:20332299 NCBI chr10:83,411,197...83,435,078
Ensembl chr10:83,411,313...83,435,078
JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 decreases expression ISO Chloroquine results in decreased expression of ERBB3 protein CTD PMID:20332299 NCBI chr 7:994,549...1,015,876
Ensembl chr 7:996,225...1,015,525
JBrowse link
G Ergic3 ERGIC and golgi 3 multiple interactions ISO ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] CTD PMID:27588471 NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813
JBrowse link
G Fads2 fatty acid desaturase 2 decreases expression EXP Chloroquine results in decreased expression of FADS2 mRNA CTD PMID:19393257 NCBI chr 1:206,707,384...206,747,333
Ensembl chr 1:206,708,783...206,748,789
JBrowse link
G Faslg Fas ligand multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FASL protein] CTD PMID:22341560 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215
JBrowse link
G Fbxo32 F-box protein 32 affects expression EXP Chloroquine affects the expression of FBXO32 mRNA CTD PMID:19296457 NCBI chr 7:89,731,626...89,764,761
Ensembl chr 7:89,730,232...89,765,436
JBrowse link
G Fgf1 fibroblast growth factor 1 multiple interactions EXP Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]] CTD PMID:31332898 NCBI chr18:30,686,555...30,772,667
Ensembl chr18:30,686,581...30,772,357
JBrowse link
G Fmn1 formin 1 decreases expression EXP Chloroquine results in decreased expression of FMN1 mRNA CTD PMID:19393257 NCBI chr 3:100,101,103...100,485,652
Ensembl chr 3:100,134,549...100,479,220
JBrowse link
G Foxp3 forkhead box P3 multiple interactions ISO Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 protein] CTD PMID:31900833 NCBI chr  X:14,908,494...14,924,994
Ensembl chr  X:14,908,494...14,923,838
JBrowse link
G Fth1 ferritin heavy chain 1 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]
Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein]
Chloroquine results in increased expression of FTH1 mRNA
CTD PMID:30551460 PMID:32937103 NCBI chr 1:206,627,142...206,629,430
Ensembl chr 1:206,627,103...206,725,424
JBrowse link
G Fundc1 FUN14 domain containing 1 multiple interactions ISO Chloroquine inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein] CTD PMID:32001317 NCBI chr  X:5,083,635...5,100,293
Ensembl chr  X:5,083,617...5,100,284
JBrowse link
G Gal3st1 galactose-3-O-sulfotransferase 1 multiple interactions ISO GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] CTD PMID:23880069 NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
JBrowse link
G Gja1 gap junction protein, alpha 1 multiple interactions EXP
ISO
Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of GJA1 protein]
Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]
CTD PMID:8824497 PMID:22150760 PMID:28713934 NCBI chr20:35,756,007...35,768,481
Ensembl chr20:35,755,991...35,768,582
JBrowse link
G Gjb2 gap junction protein, beta 2 decreases expression EXP Chloroquine results in decreased expression of GJB2 mRNA CTD PMID:19393257 NCBI chr15:31,260,390...31,278,222
Ensembl chr15:31,260,357...31,278,177
JBrowse link
G Glb1 galactosidase, beta 1 multiple interactions ISO [Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein CTD PMID:30025493 NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
JBrowse link
G Glp1r glucagon-like peptide 1 receptor multiple interactions EXP Chloroquine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein] CTD PMID:22925809 NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
JBrowse link
G Golga2 golgin A2 affects localization ISO Chloroquine affects the localization of GOLGA2 protein CTD PMID:29940786 NCBI chr 3:15,583,862...15,604,279
Ensembl chr 3:15,584,039...15,604,279
JBrowse link
G Gpnmb glycoprotein nmb increases expression EXP Chloroquine results in increased expression of GPNMB mRNA CTD PMID:19393257 NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
JBrowse link
G Gpr182 G protein-coupled receptor 182 decreases expression EXP Chloroquine results in decreased expression of GPR182 mRNA CTD PMID:19393257 NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]; Chloroquine promotes the reaction [Acetaminophen results in increased activity of GPT protein] CTD PMID:26498332 PMID:33271250 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Gpx4 glutathione peroxidase 4 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of GPX4 mRNA
Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]
CTD PMID:23607047 NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B multiple interactions EXP Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B] CTD PMID:26327526 NCBI chr 4:168,580,824...169,044,110
Ensembl chr 4:168,599,546...169,042,279
JBrowse link
G Gsr glutathione-disulfide reductase decreases activity
decreases expression
multiple interactions
ISO Chloroquine results in decreased activity of GSR protein
Chloroquine results in decreased expression of GSR mRNA
Quercetin inhibits the reaction [Chloroquine results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GSR mRNA]
CTD PMID:23607047 NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
JBrowse link
G Hbg1 hemoglobin subunit gamma 1 decreases expression EXP Chloroquine results in decreased expression of HBG1 mRNA CTD PMID:19393257 NCBI chr 1:158,271,993...158,273,371
Ensembl chr 1:158,271,873...158,273,425
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha decreases expression ISO Chloroquine results in decreased expression of HIF1A protein CTD PMID:32060308 NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
JBrowse link
G Hk2 hexokinase 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein] CTD PMID:30821613 NCBI chr 4:115,234,509...115,283,530
Ensembl chr 4:115,234,509...115,283,530
JBrowse link
G Hmbs hydroxymethylbilane synthase increases response to substance ISO HMBS mutant form results in increased susceptibility to Chloroquine CTD PMID:8772850 NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B multiple interactions ISO Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein] CTD PMID:17046822 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 multiple interactions EXP Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein] CTD PMID:29870746 NCBI chr 3:18,055,507...18,059,969
Ensembl chr 3:18,055,405...18,059,891
JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HSPA8 protein alternative form CTD PMID:30821613 NCBI chr 8:41,183,397...41,187,260
Ensembl chr 8:41,183,264...41,187,259
JBrowse link
G Icam1 intercellular adhesion molecule 1 multiple interactions ISO Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]] CTD PMID:24145604 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
JBrowse link
G Ifnb1 interferon beta 1 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]] CTD PMID:28134560 NCBI chr 5:103,020,969...103,021,523
Ensembl chr 5:103,020,969...103,021,523
JBrowse link
G Ifng interferon gamma multiple interactions ISO [Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA
[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IFNG protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]
CTD PMID:22341560 PMID:29594315 PMID:30482226 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta decreases expression ISO Chloroquine results in decreased expression of IKBKB protein CTD PMID:26116531 NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
JBrowse link
G Ikbkg inhibitor of nuclear factor kappa B kinase regulatory subunit gamma decreases expression ISO Chloroquine results in decreased expression of IKBKG protein CTD PMID:26116531 NCBI chr  X:152,216,485...152,241,476
Ensembl chr  X:152,216,596...152,239,499
JBrowse link
G Il10 interleukin 10 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL10 protein] CTD PMID:22341560 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il13 interleukin 13 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL13 protein] CTD PMID:22341560 NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
JBrowse link
G Il17a interleukin 17A multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL17A protein] CTD PMID:22341560 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
JBrowse link
G Il1a interleukin 1 alpha increases expression
multiple interactions
ISO Chloroquine results in increased expression of IL1A
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1A protein]
CTD PMID:15139008 PMID:22341560 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta increases expression
decreases expression
multiple interactions
ISO Chloroquine results in increased expression of IL1B
Chloroquine results in decreased expression of IL1B mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]
CTD PMID:15139008 PMID:21051542 PMID:22341560 PMID:26498332 PMID:29594315 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of IL2 mRNA; Chloroquine results in decreased expression of IL2 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein]
[Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
CTD PMID:7554381 PMID:22341560 PMID:29594315 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein] CTD PMID:22341560 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein] CTD PMID:22341560 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 decreases expression
multiple interactions
decreases secretion
increases expression
ISO
EXP
Chloroquine results in decreased expression of IL6 protein
Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]]
Chloroquine results in decreased secretion of IL6 protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]]
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Bortezomib inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]
Chloroquine results in increased expression of IL6
CTD PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 More... NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Irf3 interferon regulatory factor 3 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]] CTD PMID:22341560 PMID:25780039 PMID:28134560 NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
JBrowse link
G Itgam integrin subunit alpha M multiple interactions ISO [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with Chloroquine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; Chloroquine inhibits the reaction [Tretinoin affects the localization of ITGAM protein] CTD PMID:29743969 NCBI chr 1:182,659,047...182,709,495
Ensembl chr 1:182,659,000...182,709,503
JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO chloroquine co-treated with anlotinib decreases phosphorylation of JAK2 protein in lung epithelium RGD PMID:30755242 RGD:149735343 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
JBrowse link
G Lamb1 laminin subunit beta 1 multiple interactions ISO Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein] CTD PMID:22150760 NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
JBrowse link
G Lamp2 lysosomal-associated membrane protein 2 multiple interactions ISO [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein alternative form; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein] CTD PMID:30821613 NCBI chr  X:117,173,097...117,222,090
Ensembl chr  X:117,057,606...117,260,522
JBrowse link
G Lcn2 lipocalin 2 increases expression EXP Chloroquine results in increased expression of LCN2 mRNA CTD PMID:19393257 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Ldlr low density lipoprotein receptor multiple interactions ISO Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]] CTD PMID:30950489 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580
JBrowse link
G Lep leptin multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein] CTD PMID:22341560 NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
JBrowse link
G Lepr leptin receptor increases expression ISO Chloroquine results in increased expression of LEPR protein CTD PMID:31199479 NCBI chr 5:116,294,409...116,477,904
Ensembl chr 5:116,289,823...116,475,908
JBrowse link
G Ltb lymphotoxin beta increases expression ISO Chloroquine results in increased expression of LTB CTD PMID:15139008 NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
JBrowse link
G M6pr mannose-6-phosphate receptor, cation dependent affects expression
affects localization
EXP
ISO
Chloroquine affects the expression of M6PR mRNA
Chloroquine affects the localization of M6PR protein
CTD PMID:15712280 PMID:29940786 NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
JBrowse link
G Map1lc3a microtubule-associated protein 1 light chain 3 alpha increases expression ISO Chloroquine results in increased expression of MAP1LC3A protein; Chloroquine results in increased expression of MAP1LC3A protein modified form CTD PMID:30280407 PMID:30871063 NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
JBrowse link
G Map1lc3b microtubule-associated protein 1 light chain 3 beta increases expression
decreases degradation
increases lipidation
multiple interactions
affects localization
increases cleavage
EXP
ISO
Chloroquine results in increased expression of MAP1LC3B mRNA; Chloroquine results in increased expression of MAP1LC3B protein; Chloroquine results in increased expression of MAP1LC3B protein modified form
Chloroquine results in decreased degradation of MAP1LC3B protein modified form
Chloroquine results in increased lipidation of MAP1LC3B protein
Chloroquine promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [trichostatin A results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]
Chloroquine affects the localization of MAP1LC3B protein
Chloroquine results in increased cleavage of MAP1LC3B protein
[Ethanol co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased lipidation of MAP1LC3B protein]; MJN110 affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
[Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; [Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [dorsomorphin results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline affects the localization of MAP1LC3B protein]; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Ethanol results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [fosbretabulin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Rifampin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [YM 155 results in increased lipidation of MAP1LC3B protein]; Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein; Chloroquine results in increased lipidation of and results in increased cleavage of MAP1LC3B protein; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Paraquat inhibits the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]
CTD PMID:17643062 PMID:23880069 PMID:24095927 PMID:24145604 PMID:24161432 More... NCBI chr19:49,665,795...49,673,655
Ensembl chr19:49,665,791...49,677,690
JBrowse link
G Map2 microtubule-associated protein 2 multiple interactions EXP Chloroquine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein] CTD PMID:26676567 NCBI chr 9:67,723,422...67,981,886
Ensembl chr 9:67,723,371...67,979,809
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation
multiple interactions
decreases phosphorylation
ISO Chloroquine results in increased phosphorylation of MAPK1 protein
[Chloroquine co-treated with Cannabidiol] affects the phosphorylation of MAPK1 protein; Chloroquine affects the reaction [Cannabidiol affects the phosphorylation of MAPK1 protein]
Chloroquine results in decreased phosphorylation of MAPK1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]
CTD PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 PMID:32060308 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
increases phosphorylation
ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]
[Chloroquine co-treated with Cannabidiol] affects the phosphorylation of MAPK3 protein; Chloroquine affects the reaction [Cannabidiol affects the phosphorylation of MAPK3 protein]
Chloroquine results in decreased phosphorylation of MAPK3 protein
Chloroquine results in increased phosphorylation of MAPK3 protein
CTD PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 PMID:32060308 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]
Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Chloroquine promotes the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]
CTD PMID:22341560 PMID:28134560 PMID:31648047 NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
JBrowse link
G Mapt microtubule-associated protein tau affects expression
multiple interactions
EXP Chloroquine affects the expression of MAPT mRNA; Chloroquine affects the expression of MAPT protein
Chloroquine affects the localization of and affects the degradation of MAPT protein
CTD PMID:9690670 NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member multiple interactions ISO Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein] CTD PMID:25078063 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mir155 microRNA 155 multiple interactions ISO [Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA CTD PMID:27692344 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
JBrowse link
G Mir224 microRNA 224 ISO inhibits the reaction [Amiodarone decreased expression of miR224 in a human hepatoma cell line] RGD PMID:23913306 RGD:18182923 NCBI chr  X:150,065,088...150,065,169
Ensembl chr  X:150,065,088...150,065,169
JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions ISO [Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein
[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]
CTD PMID:30025493 PMID:30482226 NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
increases expression
ISO Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
Chloroquine results in increased expression of MMP13 mRNA; Chloroquine results in increased expression of MMP13 protein
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]
CTD PMID:23331101 PMID:24273604 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO Chloroquine results in decreased expression of MMP2 mRNA; Chloroquine results in decreased expression of MMP2 protein CTD PMID:24273604 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions
increases expression
decreases expression
ISO Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Oxygen deficiency inhibits the reaction [Chloroquine results in decreased expression of MMP9 mRNA]
Chloroquine results in increased expression of MMP9 mRNA
Chloroquine results in decreased expression of MMP9 mRNA; Chloroquine results in decreased expression of MMP9 protein
CTD PMID:24145604 PMID:24273604 PMID:30551460 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
JBrowse link
G Mtor mechanistic target of rapamycin kinase multiple interactions
decreases phosphorylation
increases expression
ISO Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein]
Chloroquine results in decreased phosphorylation of MTOR protein
Chloroquine results in increased expression of MTOR protein
CTD PMID:25884947 PMID:27180204 PMID:31310755 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
JBrowse link
G Mttp microsomal triglyceride transfer protein multiple interactions
increases expression
ISO [benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Chloroquine] results in increased expression of MTTP protein
Chloroquine results in increased expression of MTTP protein
CTD PMID:34516972 NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
JBrowse link
G Muc1 mucin 1, cell surface associated multiple interactions ISO Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein] CTD PMID:22457794 NCBI chr 2:174,635,559...174,640,738
Ensembl chr 2:174,635,995...174,640,733
JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 mRNA] CTD PMID:22341560 NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
JBrowse link
G Myom2 myomesin 2 increases expression EXP Chloroquine results in increased expression of MYOM2 mRNA CTD PMID:19393257 NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
JBrowse link
G Nacc1 nucleus accumbens associated 1 multiple interactions ISO Chloroquine affects the reaction [NACC1 affects the susceptibility to Cisplatin] CTD PMID:21743489 NCBI chr19:23,468,688...23,486,528
Ensembl chr19:23,468,419...23,486,528
JBrowse link
G Ncoa4 nuclear receptor coactivator 4 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]
Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
Chloroquine results in increased expression of NCOA4 mRNA
CTD PMID:30551460 PMID:32937103 NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,556
Ensembl chr16:7,366,542...7,409,556
JBrowse link
G Ndrg1 N-myc downstream regulated 1 multiple interactions ISO Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of NDRG1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased expression of NDRG1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the susceptibility to [fosbretabulin co-treated with Chloroquine] CTD PMID:28906492 NCBI chr 7:98,684,487...98,725,869
Ensembl chr 7:98,684,487...98,725,880
JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of NFKB1 protein
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein]
CTD PMID:22341560 PMID:26116531 NCBI chr 2:224,016,214...224,132,135
Ensembl chr 2:224,016,214...224,110,404
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein; Chloroquine inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]
CTD PMID:24085292 PMID:28134560 PMID:30821613 NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 multiple interactions ISO NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] CTD PMID:23880069 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO Chloroquine promotes the reaction [sunitinib results in increased expression of NOS2 protein] CTD PMID:24751611 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
JBrowse link
G Notch1 notch receptor 1 multiple interactions ISO [Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein CTD PMID:29917191 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531
JBrowse link
G Nppc natriuretic peptide C decreases expression EXP Chloroquine results in decreased expression of NPPC mRNA CTD PMID:19393257 NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO Chloroquine binds to and results in decreased activity of NQO2 protein CTD PMID:15078100 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 decreases expression ISO Chloroquine results in decreased expression of NR0B2 mRNA CTD PMID:24189133 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Nr4a2 nuclear receptor subfamily 4, group A, member 2 multiple interactions ISO Chloroquine binds to and results in increased activity of NR4A2 protein CTD PMID:31175960 NCBI chr 3:41,689,847...41,707,036
Ensembl chr 3:41,689,851...41,697,877
JBrowse link
G Ocln occludin increases expression ISO Chloroquine results in increased expression of OCLN mRNA CTD PMID:25752684 NCBI chr 2:31,657,217...31,707,466
Ensembl chr 2:31,657,220...31,764,150
JBrowse link
G Optn optineurin multiple interactions ISO Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein] CTD PMID:25884947 NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
JBrowse link
G Osgin1 oxidative stress induced growth inhibitor 1 decreases expression EXP Chloroquine results in decreased expression of OSGIN1 mRNA CTD PMID:19393257 NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions
increases cleavage
EXP
ISO
Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]
Chloroquine results in increased cleavage of PARP1 protein
[Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]
CTD PMID:27658547 PMID:28906492 PMID:29111403 PMID:30025493 PMID:30338810 More... NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pink1 PTEN induced kinase 1 multiple interactions ISO Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PINK1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]] CTD PMID:33271250 NCBI chr 5:150,530,523...150,542,635
Ensembl chr 5:150,530,523...150,542,635
JBrowse link
G Plin3 perilipin 3 multiple interactions ISO Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA]; Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 protein] CTD PMID:20628022 NCBI chr 9:1,111,178...1,123,117
Ensembl chr 9:1,102,366...1,123,147
JBrowse link
G Pomc proopiomelanocortin multiple interactions EXP Chloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones] CTD PMID:2993719 NCBI chr 6:26,939,844...26,945,666
Ensembl chr 6:26,939,837...26,945,664
JBrowse link
G Ppt1 palmitoyl-protein thioesterase 1 multiple interactions ISO Chloroquine analog binds to and results in decreased activity of PPT1 protein; Chloroquine binds to and results in decreased activity of PPT1 protein CTD PMID:30442709 NCBI chr 5:135,121,176...135,141,076
Ensembl chr 5:135,121,163...135,142,048
JBrowse link
G Prkn parkin RBR E3 ubiquitin protein ligase multiple interactions ISO Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PRKN protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]] CTD PMID:33271250 NCBI chr 1:48,688,651...49,882,520
Ensembl chr 1:48,690,556...49,882,555
JBrowse link
G Prlr prolactin receptor decreases expression EXP Chloroquine results in decreased expression of PRLR mRNA CTD PMID:19393257 NCBI chr 2:59,134,147...59,324,719
Ensembl chr 2:59,134,588...59,324,718
JBrowse link
G Pten phosphatase and tensin homolog increases expression ISO Chloroquine results in increased expression of PTEN mRNA CTD PMID:31310755 NCBI chr 1:230,631,303...230,696,754
Ensembl chr 1:230,630,338...230,696,838
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] CTD PMID:24145604 NCBI chr13:62,164,080...62,169,770
Ensembl chr13:62,163,932...62,172,188
JBrowse link
G Rbpj recombination signal binding protein for immunoglobulin kappa J region increases expression ISO Chloroquine results in increased expression of RBPJ protein CTD PMID:22302987 NCBI chr14:57,338,493...57,523,330
Ensembl chr14:57,338,507...57,523,353
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
decreases expression
increases activity
ISO
EXP
[Chloroquine co-treated with Cannabidiol] results in decreased phosphorylation of RELA protein; Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased activity of RELA protein]
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of RELA protein]
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of RELA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]
Chloroquine results in decreased expression of RELA protein
CTD PMID:15139008 PMID:24990399 PMID:26116531 PMID:28134560 PMID:32060308 NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
JBrowse link
G Rheb Ras homolog, mTORC1 binding multiple interactions EXP Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein] CTD PMID:22689575 NCBI chr 4:10,278,970...10,320,160
Ensembl chr 4:10,279,370...10,320,160
JBrowse link
G Rps6kb1 ribosomal protein S6 kinase B1 decreases phosphorylation
multiple interactions
increases expression
ISO
EXP
Chloroquine results in decreased phosphorylation of RPS6KB1 protein
Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]
Chloroquine results in increased expression of RPS6KB1 protein modified form
CTD PMID:22689575 PMID:25884947 PMID:31310755 NCBI chr10:71,323,777...71,367,908
Ensembl chr10:71,323,777...71,367,908
JBrowse link
G Runx2 RUNX family transcription factor 2 multiple interactions ISO Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA] CTD PMID:23111315 NCBI chr 9:16,167,504...16,492,826
Ensembl chr 9:16,167,482...16,492,167
JBrowse link
G Scarb1 scavenger receptor class B, member 1 decreases expression
multiple interactions
EXP
ISO
Chloroquine results in decreased expression of SCARB1 mRNA
[Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
CTD PMID:19393257 PMID:20404351 NCBI chr12:31,296,143...31,362,649
Ensembl chr12:31,296,156...31,362,647
JBrowse link
G Sccpdh saccharopine dehydrogenase (putative) decreases expression EXP Chloroquine results in decreased expression of SCCPDH mRNA CTD PMID:19393257 NCBI chr13:91,400,120...91,421,875
Ensembl chr13:91,400,190...91,422,222
JBrowse link
G Scd stearoyl-CoA desaturase decreases expression EXP Chloroquine results in decreased expression of SCD1 mRNA CTD PMID:19393257 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
JBrowse link
G Senp6 SUMO specific peptidase 6 multiple interactions ISO [Lipopolysaccharides co-treated with Chloroquine] results in increased expression of SENP6 protein CTD PMID:26807181 NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170
JBrowse link
G Serpina3n serine (or cysteine) peptidase inhibitor, clade A, member 3N affects localization EXP Chloroquine affects the localization of SERPINA3 protein CTD PMID:8616629 NCBI chr 6:123,323,632...123,331,166
Ensembl chr 6:123,323,629...123,332,433
JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein] CTD PMID:30341573 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
JBrowse link
G Slc12a1 solute carrier family 12 member 1 decreases expression ISO Chloroquine results in decreased expression of SLC12A1 protein CTD PMID:22791344 NCBI chr 3:112,406,140...112,482,913
Ensembl chr 3:112,406,140...112,482,899
JBrowse link
G Slc14a2 solute carrier family 14 member 2 multiple interactions ISO Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein] CTD PMID:22791344 NCBI chr18:71,612,460...72,039,462
Ensembl chr18:71,612,460...71,792,968
JBrowse link
G Slc19a3 solute carrier family 19 member 3 multiple interactions ISO Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine] CTD PMID:26528626 NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
JBrowse link
G Slc22a2 solute carrier family 22 member 2 multiple interactions ISO Chloroquine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:27504015 NCBI chr 1:48,121,061...48,163,268
Ensembl chr 1:48,121,061...48,163,268
JBrowse link
G Slc2a4 solute carrier family 2 member 4 affects localization
multiple interactions
EXP Chloroquine affects the localization of SLC2A4 protein
1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; [[Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein; gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]
CTD PMID:27160165 NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate] CTD PMID:27504015 NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
JBrowse link
G Snai1 snail family transcriptional repressor 1 multiple interactions EXP Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA] CTD PMID:30053495 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Sod1 superoxide dismutase 1 multiple interactions
decreases expression
ISO Quercetin inhibits the reaction [Chloroquine results in decreased expression of SOD1 mRNA] CTD PMID:23607047 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
JBrowse link
G Sort1 sortilin 1 decreases expression
multiple interactions
ISO Chloroquine results in decreased expression of SORT1 protein
Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]
CTD PMID:25805502 PMID:30950489 NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
JBrowse link
G Sqstm1 sequestosome 1 multiple interactions
increases expression
ISO
EXP
Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [fosbretabulin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [YM 155 results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]
Chloroquine inhibits the reaction [cadmium acetate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Glucose results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]]
Chloroquine inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Sunitinib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]
CTD PMID:21858812 PMID:22927544 PMID:23651616 PMID:24262987 PMID:24751611 More... NCBI chr10:34,525,517...34,536,685
Ensembl chr10:34,525,519...34,536,673
JBrowse link
G Ssb small RNA binding exonuclease protection factor La multiple interactions ISO Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein] CTD PMID:25915936 NCBI chr 3:54,616,616...54,626,203
Ensembl chr 3:54,616,619...54,626,203
JBrowse link
G Star steroidogenic acute regulatory protein decreases expression EXP Chloroquine results in decreased expression of STAR mRNA CTD PMID:19393257 NCBI chr16:66,267,094...66,274,368
Ensembl chr16:66,264,807...66,271,672
JBrowse link
G Stc2 stanniocalcin 2 decreases expression EXP Chloroquine results in decreased expression of STC2 mRNA CTD PMID:19393257 NCBI chr10:16,251,046...16,260,815
Ensembl chr10:16,250,853...16,262,973
JBrowse link
G Strap serine/threonine kinase receptor associated protein decreases expression EXP Chloroquine results in decreased expression of STRAP mRNA CTD PMID:19393257 NCBI chr 4:170,646,042...170,660,291
Ensembl chr 4:170,646,001...170,660,828
JBrowse link
G Syp synaptophysin multiple interactions EXP Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP] CTD PMID:26327526 NCBI chr  X:14,849,444...14,864,553
Ensembl chr  X:14,849,444...14,864,745
JBrowse link
G Tardbp TAR DNA binding protein increases expression
multiple interactions
ISO Chloroquine results in increased expression of TARDBP protein
Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
CTD PMID:25884947 NCBI chr 5:159,050,518...159,062,218
Ensembl chr 5:159,051,799...159,062,055
JBrowse link
G Tet2 tet methylcytosine dioxygenase 2 multiple interactions ISO Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 protein] CTD PMID:31900833 NCBI chr 2:221,988,645...222,072,813
Ensembl chr 2:221,988,645...222,072,534
JBrowse link
G Tgoln2 trans-golgi network protein 2 affects localization ISO Chloroquine affects the localization of TGOLN2 protein CTD PMID:29940786 NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
JBrowse link
G Thra thyroid hormone receptor alpha multiple interactions ISO Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein] CTD PMID:24262987 NCBI chr10:83,701,885...83,729,408
Ensembl chr10:83,700,755...83,729,936
JBrowse link
G Ticam2 toll-like receptor adaptor molecule 2 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA] CTD PMID:22341560 NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 multiple interactions
decreases expression
ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein]
Chloroquine results in decreased expression of TIMP1 mRNA
Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
CTD PMID:22341560 PMID:30551460 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP2 protein] CTD PMID:22341560 NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
JBrowse link
G Tlr3 toll-like receptor 3 multiple interactions ISO Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein] CTD PMID:21398612 NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
JBrowse link
G Tlr4 toll-like receptor 4 multiple interactions ISO Chloroquine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein] CTD PMID:22341560 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
JBrowse link
G Tlr7 toll-like receptor 7 decreases activity ISO Chloroquine results in decreased activity of TLR7 protein CTD PMID:27385120 NCBI chr  X:27,027,380...27,054,309
Ensembl chr  X:27,027,425...27,054,754
JBrowse link
G Tlr8 toll-like receptor 8 decreases activity ISO Chloroquine results in decreased activity of TLR8 protein CTD PMID:27385120 NCBI chr  X:27,091,780...27,116,092
Ensembl chr  X:27,091,778...27,116,549
JBrowse link
G Tlr9 toll-like receptor 9 decreases activity
decreases expression
multiple interactions
increases expression
ISO
EXP
Chloroquine results in decreased activity of TLR9 protein
Chloroquine results in decreased expression of TLR9 protein
Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein]
Chloroquine results in increased expression of TLR9 mRNA
Chloroquine inhibits the reaction [CpG ODN 2006 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [CpG ODN 2395 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TLR9 mRNA]; Oxygen deficiency inhibits the reaction [Chloroquine results in increased expression of TLR9 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
CTD PMID:21398612 PMID:22595112 PMID:24273604 PMID:24990399 NCBI chr 8:106,864,680...106,868,796
Ensembl chr 8:106,864,680...106,868,796
JBrowse link
G Tm7sf2 transmembrane 7 superfamily member 2 decreases expression EXP Chloroquine results in decreased expression of TM7SF2 mRNA CTD PMID:19393257 NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
JBrowse link
G Tnf tumor necrosis factor decreases expression
multiple interactions
decreases secretion
increases expression
ISO
EXP
Chloroquine results in decreased expression of TNF protein
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]]
[Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]
Chloroquine results in decreased secretion of TNF protein
Chloroquine results in increased expression of TNF
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]
CTD PMID:8244452 PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Tnfrsf10b TNF receptor superfamily member 10b increases expression ISO Chloroquine results in increased expression of TNFRSF10A protein CTD PMID:27692344 NCBI chr15:44,839,818...44,867,582
Ensembl chr15:44,840,386...44,867,467
JBrowse link
G Tnfrsf1a TNF receptor superfamily member 1A multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein] CTD PMID:22341560 NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
JBrowse link
G Tnfrsf1b TNF receptor superfamily member 1B multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1B protein] CTD PMID:22341560 NCBI chr 5:157,070,642...157,104,216
Ensembl chr 5:157,070,642...157,104,206
JBrowse link
G Tomm20 translocase of outer mitochondrial membrane 20 multiple interactions ISO Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein] CTD PMID:30209975 NCBI chr19:54,925,197...54,935,188
Ensembl chr19:54,923,402...54,935,198
JBrowse link
G Tp53 tumor protein p53 increases activity
multiple interactions
ISO Chloroquine results in increased activity of TP53; Chloroquine results in increased activity of TP53 protein
Chloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]
TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
CTD PMID:11589424 PMID:12082016 PMID:18089834 PMID:22927544 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression
multiple interactions
ISO Chloroquine results in increased expression of TRIB3 protein
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; betulinic acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
CTD PMID:30482226 NCBI chr 3:140,809,634...140,815,230
Ensembl chr 3:140,809,043...140,814,497
JBrowse link
G Trim63 tripartite motif containing 63 affects expression EXP Chloroquine affects the expression of TRIM63 mRNA CTD PMID:19296457 NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
JBrowse link
G Trpc1 transient receptor potential cation channel, subfamily C, member 1 multiple interactions EXP Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein] CTD PMID:32956540 NCBI chr 8:96,263,322...96,314,197
Ensembl chr 8:96,263,329...96,314,276
JBrowse link
G Ubc ubiquitin C increases expression EXP Chloroquine results in increased expression of UBC mRNA CTD PMID:19296457 NCBI chr12:31,238,889...31,243,924
Ensembl chr12:31,239,152...31,243,925
JBrowse link
G Usp2 ubiquitin specific peptidase 2 multiple interactions
increases expression
ISO Chloroquine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of USP2 mRNA]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Chloroquine results in increased expression of USP2 mRNA] CTD PMID:28134560 NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
JBrowse link
G Usp25 ubiquitin specific peptidase 25 increases expression
multiple interactions
ISO Chloroquine results in increased expression of USP25 mRNA; Chloroquine results in increased expression of USP25 protein
[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Chloroquine] results in increased expression of USP25 protein; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP25 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]
CTD PMID:28134560 NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348
JBrowse link
G Usp28 ubiquitin specific peptidase 28 multiple interactions
increases expression
ISO Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP28 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP28 mRNA] CTD PMID:28134560 NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229
JBrowse link
G Usp7 ubiquitin specific peptidase 7 increases expression
multiple interactions
ISO Chloroquine results in increased expression of USP7 mRNA
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP7 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP7 mRNA]
CTD PMID:28134560 NCBI chr10:6,880,684...6,925,033
Ensembl chr10:6,828,795...6,925,355
JBrowse link
G Vcp valosin-containing protein multiple interactions ISO Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]
Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
CTD PMID:25884947 NCBI chr 5:57,210,167...57,229,571
Ensembl chr 5:57,210,168...57,229,571
JBrowse link
G Vsnl1 visinin-like 1 decreases expression EXP Chloroquine results in decreased expression of VSNL1 mRNA CTD PMID:19393257 NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
JBrowse link
G Xcl1 X-C motif chemokine ligand 1 multiple interactions ISO Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of XCL1 protein] CTD PMID:22341560 NCBI chr13:77,248,865...77,252,308
Ensembl chr13:77,248,717...77,252,329
JBrowse link
ciprofloxacin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression ISO Ciprofloxacin results in decreased expression of ABCC2 mRNA CTD PMID:24657338 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcc3 ATP binding cassette subfamily C member 3 increases expression ISO Ciprofloxacin results in increased expression of ABCC3 mRNA CTD PMID:24657338 NCBI chr10:79,296,681...79,342,749
Ensembl chr10:79,296,693...79,342,595
JBrowse link
G Abcc4 ATP binding cassette subfamily C member 4 increases export
multiple interactions
increases expression
ISO ABCC4 protein results in increased export of Ciprofloxacin
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin
Ciprofloxacin results in increased expression of ABCC4 mRNA; Ciprofloxacin results in increased expression of ABCC4 protein
[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin; Gemfibrozil inhibits the reaction [[Ciprofloxacin results in increased expression of ABCC4 protein] which results in decreased uptake of Ciprofloxacin]
CTD PMID:19307362 PMID:22162766 NCBI chr15:95,541,186...95,774,898
Ensembl chr15:95,542,315...95,774,283
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 increases expression ISO Ciprofloxacin results in increased expression of ABCG2 protein CTD PMID:26947806 NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
JBrowse link
G Akt1 AKT serine/threonine kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of AKT1 protein CTD PMID:26947806 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO Ciprofloxacin results in increased expression of ALDH1A1 protein CTD PMID:26947806 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases localization
increases expression
ISO BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein]
Ciprofloxacin results in increased expression of BAX protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO [Etoposide co-treated with Ciprofloxacin] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [Ciprofloxacin results in increased localization of BAX protein] CTD PMID:11832715 PMID:12063570 NCBI chr13:22,689,783...22,853,920 JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity
ISO Ciprofloxacin results in increased cleavage of and results in increased activity of CASP3 protein
Ciprofloxacin results in increased activity of CASP3 protein
CTD PMID:10741713 PMID:11832715 PMID:11875713 PMID:12632069 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
JBrowse link
G Casp8 caspase 8 increases activity ISO Ciprofloxacin results in increased activity of CASP8 protein CTD PMID:11875713 NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
JBrowse link
G Casp9 caspase 9 increases activity ISO Ciprofloxacin results in increased activity of CASP9 protein CTD PMID:11875713 NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
JBrowse link
G Cav1 caveolin 1 increases expression ISO Ciprofloxacin results in increased expression of CAV1 protein CTD PMID:26947806 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
JBrowse link
G Ccnb1 cyclin B1 decreases expression
increases expression
ISO
EXP
Ciprofloxacin results in decreased expression of CCNB1 protein
Ciprofloxacin results in increased expression of CCNB1 mRNA; Ciprofloxacin results in increased expression of CCNB1 protein
CTD PMID:10741713 PMID:18512786 NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
JBrowse link
G Ccne1 cyclin E1 decreases expression ISO Ciprofloxacin results in decreased expression of CCNE1 protein CTD PMID:10741713 NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
JBrowse link
G Cd44 CD44 molecule (Indian blood group) increases expression ISO Ciprofloxacin results in increased expression of CD44 protein CTD PMID:26947806 NCBI chr 3:89,155,850...89,244,615
Ensembl chr 3:89,157,058...89,244,620
JBrowse link
G Cdk1 cyclin-dependent kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CDK1 mRNA; Ciprofloxacin results in increased expression of CDK1 protein CTD PMID:18512786 NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases phosphorylation ISO Ciprofloxacin results in decreased phosphorylation of CDK2 protein CTD PMID:10741713 NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO Ciprofloxacin results in decreased expression of CDKN1A; Ciprofloxacin results in decreased expression of CDKN1A protein CTD PMID:10741713 PMID:12063570 PMID:12632069 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA] CTD PMID:11052920 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Chek1 checkpoint kinase 1 increases expression EXP Ciprofloxacin results in increased expression of CHEK1 protein CTD PMID:18512786 NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
JBrowse link
G Csf2 colony stimulating factor 2 increases expression ISO Ciprofloxacin results in increased expression of CSF2 protein CTD PMID:11125792 NCBI chr10:38,386,945...38,388,926
Ensembl chr10:38,386,945...38,389,199
JBrowse link
G Cxcl2 C-X-C motif chemokine ligand 2 decreases expression ISO Ciprofloxacin results in decreased expression of CXCL2 protein CTD PMID:18197910 NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of Clozapine; [Ciprofloxacin results in decreased activity of CYP1A2 protein] which results in increased abundance of norclozapine; Ciprofloxacin inhibits the reaction [CYP1A2 protein affects the metabolism of tizanidine]; Ciprofloxacin inhibits the reaction [CYP1A2 protein results in decreased methylation of Caffeine] CTD PMID:11145498 PMID:11151749 PMID:15592331 PMID:18816299 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases expression EXP Ciprofloxacin results in decreased expression of CYP2C11 mRNA CTD PMID:12621481 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity ISO Ciprofloxacin results in decreased activity of CYP3A4 protein CTD PMID:11145498 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
G Cyp3a23-3a1 cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1 decreases expression EXP Ciprofloxacin results in decreased expression of CYP3A23-3A1 mRNA CTD PMID:12621481 NCBI chr12:9,256,159...9,285,020
Ensembl chr12:9,254,475...9,285,030
JBrowse link
G Dhodh dihydroorotate dehydrogenase (quinone) multiple interactions
decreases activity
EXP Ciprofloxacin inhibits the reaction [DHODH protein results in increased oxidation of 4,5-dihydroorotic acid]
Ciprofloxacin results in decreased activity of DHODH protein
CTD PMID:9776318 NCBI chr19:37,551,858...37,573,327
Ensembl chr19:37,558,177...37,591,654
JBrowse link
G Fgf19 fibroblast growth factor 19 decreases expression ISO Ciprofloxacin results in decreased expression of FGF15 mRNA CTD PMID:24657338 NCBI chr 1:200,056,656...200,059,944
Ensembl chr 1:200,056,644...200,060,287
JBrowse link
G G6pd glucose-6-phosphate dehydrogenase increases response to substance ISO G6PD protein mutant form results in increased susceptibility to Ciprofloxacin CTD PMID:20127091 NCBI chr  X:152,201,081...152,220,863
Ensembl chr  X:152,201,098...152,220,801
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO [Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein; Buthionine Sulfoximine promotes the reaction [[Atorvastatin co-treated with Ciprofloxacin] results in increased expression of GPT protein] CTD PMID:29679711 NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
JBrowse link
G Ifng interferon gamma multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in increased expression of IFNG mRNA; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IFNG protein]]
Ciprofloxacin results in decreased expression of IFNG protein
CTD PMID:16006447 PMID:16968468 PMID:18337667 PMID:19401694 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
JBrowse link
G Il10 interleukin 10 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of IL10 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL10 protein]]
CTD PMID:16939481 PMID:19401694 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
JBrowse link
G Il1a interleukin 1 alpha multiple interactions ISO Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]] CTD PMID:16968468 NCBI chr 3:116,526,601...116,537,055
Ensembl chr 3:116,526,604...116,536,822
JBrowse link
G Il1b interleukin 1 beta multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]
Ciprofloxacin results in decreased expression of IL1B protein
CTD PMID:9267955 PMID:11052920 PMID:12428247 PMID:16148020 PMID:18197910 More... NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
JBrowse link
G Il2 interleukin 2 multiple interactions EXP Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL2 protein]] CTD PMID:19401694 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566
JBrowse link
G Il3 interleukin 3 increases expression ISO Ciprofloxacin results in increased expression of IL3 mRNA; Ciprofloxacin results in increased expression of IL3 protein CTD PMID:11125792 NCBI chr10:38,405,716...38,408,066
Ensembl chr10:38,405,716...38,408,066
JBrowse link
G Il4 interleukin 4 decreases expression ISO Ciprofloxacin results in decreased expression of IL4 protein CTD PMID:16006447 NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]
Ciprofloxacin inhibits the reaction [irinotecan inhibits the reaction [Mitogens results in increased expression of IL6 protein]]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of IL6 protein]]
CTD PMID:9267955 PMID:11052920 PMID:19401694 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 affects binding ISO Ciprofloxacin binds to KCNH2 protein CTD PMID:34058295 NCBI chr 4:10,826,834...10,859,009
Ensembl chr 4:10,826,928...10,859,008
JBrowse link
G Lcn2 lipocalin 2 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of LCN2 mRNA CTD PMID:29679711 NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
JBrowse link
G Mapk1 mitogen activated protein kinase 1 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK1 protein CTD PMID:26947806 NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
JBrowse link
G Mapk3 mitogen activated protein kinase 3 increases phosphorylation ISO Ciprofloxacin results in increased phosphorylation of MAPK3 protein CTD PMID:26947806 NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
JBrowse link
G Mb myoglobin multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased secretion of MB protein CTD PMID:29679711 NCBI chr 7:108,759,903...108,767,134
Ensembl chr 7:108,759,904...108,767,383
JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member increases expression ISO Ciprofloxacin results in increased expression of MCL1 protein CTD PMID:32437906 NCBI chr 2:183,219,137...183,235,676
Ensembl chr 2:183,219,220...183,222,303
JBrowse link
G Mir133b microRNA 133b multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR133B mRNA CTD PMID:29679711 NCBI chr 9:23,098,134...23,098,217
Ensembl chr 9:23,098,134...23,098,217
JBrowse link
G Mir206 microRNA 206 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of MIR206 mRNA CTD PMID:29679711 NCBI chr 9:23,094,249...23,094,332
Ensembl chr 9:23,094,249...23,094,332
JBrowse link
G Mitf melanocyte inducing transcription factor decreases expression ISO Ciprofloxacin results in decreased expression of MITF protein CTD PMID:32437906 NCBI chr 4:130,409,020...130,621,145
Ensembl chr 4:130,409,217...130,621,145
JBrowse link
G Mmp1 matrix metallopeptidase 1 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP1 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP1 protein]
Ciprofloxacin results in increased expression of MMP1 mRNA
CTD PMID:12428247 PMID:16148020 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097
JBrowse link
G Mmp13 matrix metallopeptidase 13 multiple interactions
decreases expression
ISO Ciprofloxacin inhibits the reaction [IL1B protein results in increased expression of MMP13 mRNA]; Ciprofloxacin inhibits the reaction [IL1B protein results in increased secretion of MMP13 protein]
Ciprofloxacin results in decreased expression of MMP13 mRNA
CTD PMID:16148020 NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
JBrowse link
G Mmp3 matrix metallopeptidase 3 multiple interactions
increases expression
ISO Ciprofloxacin promotes the reaction [IL1B protein results in increased expression of MMP3 mRNA]; Ciprofloxacin promotes the reaction [IL1B protein results in increased secretion of MMP3 protein]
Ciprofloxacin results in increased expression of MMP3 mRNA
CTD PMID:12428247 NCBI chr 8:4,640,397...4,653,963
Ensembl chr 8:4,640,416...4,653,961
JBrowse link
G Mpo myeloperoxidase multiple interactions EXP Ciprofloxacin inhibits the reaction [Trinitrobenzenesulfonic Acid results in increased activity of MPO protein] CTD PMID:24101390 NCBI chr10:72,594,458...72,608,862
Ensembl chr10:72,594,661...72,604,819
JBrowse link
G Nanog Nanog homeobox increases expression ISO Ciprofloxacin results in increased expression of NANOG protein CTD PMID:26947806 NCBI chr 4:155,943,737...155,951,116
Ensembl chr 4:155,943,737...155,951,116
JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 decreases response to substance ISO NOD2 gene SNP results in decreased susceptibility to Ciprofloxacin CTD PMID:18371140 NCBI chr19:18,379,720...18,422,817
Ensembl chr19:18,382,439...18,417,177
JBrowse link
G Nr0b2 nuclear receptor subfamily 0, group B, member 2 increases expression ISO Ciprofloxacin results in increased expression of NR0B2 mRNA CTD PMID:24657338 NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO Ciprofloxacin results in increased cleavage of PARP1 protein CTD PMID:10741713 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
JBrowse link
G Pgd phosphogluconate dehydrogenase decreases activity EXP Ciprofloxacin results in decreased activity of PGD protein CTD PMID:15558954 NCBI chr 5:159,582,746...159,598,945
Ensembl chr 5:159,561,271...159,742,778
JBrowse link
G Plk1 polo-like kinase 1 increases expression EXP Ciprofloxacin results in increased expression of PLK1 protein CTD PMID:18512786 NCBI chr 1:176,716,420...176,726,400
Ensembl chr 1:176,716,420...176,726,400
JBrowse link
G Pon1 paraoxonase 1 decreases activity ISO Ciprofloxacin results in decreased activity of PON1 protein CTD PMID:16880604 PMID:31581362 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
JBrowse link
G Pou5f1 POU class 5 homeobox 1 increases expression ISO Ciprofloxacin results in increased expression of POU5F1 protein CTD PMID:26947806 NCBI chr20:3,223,128...3,227,891
Ensembl chr20:3,223,129...3,227,891
JBrowse link
G Prom1 prominin 1 increases expression ISO Ciprofloxacin results in increased expression of PROM1 protein CTD PMID:26947806 NCBI chr14:66,989,545...67,094,534
Ensembl chr14:66,990,160...67,094,527
JBrowse link
G RT1-A2 RT1 class Ia, locus A2 affects expression ISO Ciprofloxacin affects the expression of HLA-E mRNA CTD PMID:25811541 NCBI chr20:4,870,939...4,910,183 JBrowse link
G RT1-Db1 RT1 class II, locus Db1 affects expression ISO Ciprofloxacin affects the expression of HLA-DRB1 mRNA CTD PMID:25811541 NCBI chr20:4,548,664...4,558,237
Ensembl chr20:4,548,666...4,558,258
JBrowse link
G RT1-M3-1 RT1 class Ib, locus M3, gene 1 affects expression ISO Ciprofloxacin affects the expression of HLA-G mRNA CTD PMID:25811541 NCBI chr20:1,323,976...1,328,126
Ensembl chr20:1,287,521...1,328,117
JBrowse link
G Slc2a1 solute carrier family 2 member 1 affects localization
decreases expression
ISO Ciprofloxacin affects the localization of SLC2A1 mRNA
Ciprofloxacin results in decreased expression of SLC2A1 mRNA
CTD PMID:19022360 NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
JBrowse link
G Slc51b solute carrier family 51 subunit beta decreases expression ISO Ciprofloxacin results in decreased expression of SLC51B mRNA CTD PMID:24657338 NCBI chr 8:65,931,891...65,934,893
Ensembl chr 8:65,931,890...65,940,145
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases expression ISO Ciprofloxacin results in increased expression of SLCO1B2 mRNA CTD PMID:24657338 NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
JBrowse link
G Snai1 snail family transcriptional repressor 1 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI1 protein CTD PMID:26947806 NCBI chr 3:156,248,479...156,252,969
Ensembl chr 3:156,248,485...156,252,969
JBrowse link
G Snai2 snail family transcriptional repressor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SNAI2 protein CTD PMID:26947806 NCBI chr11:86,183,800...86,186,109
Ensembl chr11:86,181,909...86,186,200
JBrowse link
G Sox2 SRY-box transcription factor 2 decreases expression ISO Ciprofloxacin results in decreased expression of SOX2 protein CTD PMID:26947806 NCBI chr 2:117,536,929...117,539,338
Ensembl chr 2:117,536,929...117,539,338
JBrowse link
G Tgfb1 transforming growth factor, beta 1 increases expression
multiple interactions
ISO
EXP
Ciprofloxacin results in increased expression of TGFB1 mRNA
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TGFB1 mRNA
CTD PMID:18337667 PMID:19371339 NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
JBrowse link
G Tmprss2 transmembrane serine protease 2 decreases expression ISO Ciprofloxacin results in decreased expression of TMPRSS2 mRNA CTD PMID:32808185 NCBI chr11:36,934,306...36,973,779
Ensembl chr11:36,934,306...36,973,715
JBrowse link
G Tnf tumor necrosis factor multiple interactions
decreases expression
ISO
EXP
Ciprofloxacin affects the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased activity of CEBPD mRNA]; Ciprofloxacin inhibits the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of IL6 mRNA]; Ciprofloxacin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Ciprofloxacin promotes the reaction [[IL1B protein co-treated with TNF protein] results in increased expression of CXCL8 mRNA]; wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
[Ciprofloxacin co-treated with Cyclosporine] results in decreased expression of TNF mRNA; [irinotecan co-treated with Ciprofloxacin] promotes the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Ciprofloxacin inhibits the reaction [irinotecan promotes the reaction [Mitogens results in increased expression of TNF protein]]
Ciprofloxacin results in decreased expression of TNF protein
CTD PMID:9267955 PMID:11052920 PMID:16939481 PMID:16968468 PMID:18197910 More... NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
JBrowse link
G Top1 DNA topoisomerase I multiple interactions ISO [Ciprofloxacin co-treated with Camptothecin] results in decreased activity of TOP1 protein CTD PMID:18191106 NCBI chr 3:149,293,658...149,375,405
Ensembl chr 3:149,293,403...149,376,623
JBrowse link
G Top2a DNA topoisomerase II alpha affects binding
multiple interactions
ISO Ciprofloxacin binds to TOP2A protein
[Ciprofloxacin binds to TOP2A protein] inhibits the reaction [Etoposide binds to TOP2A protein]; [Ciprofloxacin binds to TOP2A protein] inhibits the reaction [F14512 binds to TOP2A protein]
CTD PMID:21413765 NCBI chr10:83,946,186...83,975,694
Ensembl chr10:83,945,735...83,976,874
JBrowse link
G Xirp1 xin actin-binding repeat containing 1 multiple interactions ISO [Buthionine Sulfoximine co-treated with Atorvastatin co-treated with Ciprofloxacin] results in increased expression of XIRP1 mRNA CTD PMID:29679711 NCBI chr 8:119,744,778...119,757,547
Ensembl chr 8:119,747,419...119,757,349
JBrowse link
Desethylchloroquine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 multiple interactions ISO [CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine] CTD PMID:12756207 PMID:12967198
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 multiple interactions
decreases activity
ISO [CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
desethylchloroquine results in decreased activity of CYP2D6 protein
CTD PMID:11124226 PMID:12756207 NCBI chr 7:113,882,584...113,891,754
Ensembl chr 7:113,881,618...113,891,759
JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 multiple interactions
decreases activity
ISO [CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
desethylchloroquine results in decreased activity of CYP3A4 protein
CTD PMID:11124226 PMID:12756207 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008
JBrowse link
glafenine term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G A2m alpha-2-macroglobulin increases expression EXP Glafenine results in increased expression of A2M mRNA CTD PMID:24136188 NCBI chr 4:154,897,770...154,947,787
Ensembl chr 4:154,897,877...154,947,786
JBrowse link
G Aadac arylacetamide deacetylase decreases expression EXP Glafenine results in decreased expression of AADAC mRNA CTD PMID:24136188 NCBI chr 2:144,163,436...144,186,086
Ensembl chr 2:144,135,319...144,174,734
JBrowse link
G Aamdc adipogenesis associated, Mth938 domain containing decreases expression EXP Glafenine results in decreased expression of AAMDC mRNA CTD PMID:24136188 NCBI chr 1:151,861,990...151,893,621
Ensembl chr 1:151,845,255...151,892,398
JBrowse link
G Abat 4-aminobutyrate aminotransferase decreases expression EXP Glafenine results in decreased expression of ABAT mRNA CTD PMID:24136188 NCBI chr10:6,996,688...7,092,835
Ensembl chr10:6,999,819...7,092,835
JBrowse link
G Abca1 ATP binding cassette subfamily A member 1 increases expression EXP Glafenine results in increased expression of ABCA1 mRNA CTD PMID:24136188 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170
JBrowse link
G Abcb11 ATP binding cassette subfamily B member 11 decreases expression EXP Glafenine results in decreased expression of ABCB11 mRNA CTD PMID:24136188 NCBI chr 3:54,016,854...54,112,797
Ensembl chr 3:54,017,127...54,112,730
JBrowse link
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression EXP Glafenine results in decreased expression of ABCB1 mRNA CTD PMID:24136188 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
JBrowse link
G Abcc2 ATP binding cassette subfamily C member 2 decreases expression EXP Glafenine results in decreased expression of ABCC2 mRNA CTD PMID:24136188 NCBI chr 1:242,664,657...242,723,239
Ensembl chr 1:242,664,657...242,723,238
JBrowse link
G Abcd3 ATP binding cassette subfamily D member 3 decreases expression EXP Glafenine results in decreased expression of ABCD3 mRNA CTD PMID:24136188 NCBI chr 2:209,852,087...209,905,763
Ensembl chr 2:209,852,087...209,906,020
JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 decreases expression EXP Glafenine results in decreased expression of ABCG5 mRNA CTD PMID:24136188 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563
JBrowse link
G Abhd1 abhydrolase domain containing 1 decreases expression EXP Glafenine results in decreased expression of ABHD1 mRNA CTD PMID:24136188 NCBI chr 6:25,422,526...25,427,514
Ensembl chr 6:25,422,526...25,427,514
JBrowse link
G Abhd14b abhydrolase domain containing 14b decreases expression EXP Glafenine results in decreased expression of ABHD14B mRNA CTD PMID:24136188 NCBI chr 8:107,087,157...107,092,122
Ensembl chr 8:107,088,069...107,092,119
JBrowse link
G Abhd2 abhydrolase domain containing 2, acylglycerol lipase increases expression EXP Glafenine results in increased expression of ABHD2 mRNA CTD PMID:24136188 NCBI chr 1:133,217,403...133,298,564
Ensembl chr 1:133,217,375...133,299,061
JBrowse link
G Abhd6 abhydrolase domain containing 6, acylglycerol lipase decreases expression EXP Glafenine results in decreased expression of ABHD6 mRNA CTD PMID:24136188 NCBI chr15:16,859,740...16,907,094
Ensembl chr15:16,859,738...16,906,985
JBrowse link
G Abi1 abl-interactor 1 decreases expression EXP Glafenine results in decreased expression of ABI1 mRNA CTD PMID:24136188 NCBI chr17:85,098,837...85,179,829
Ensembl chr17:85,098,550...85,179,792
JBrowse link
G Abraxas2 abraxas 2, BRISC complex subunit decreases expression EXP Glafenine results in decreased expression of ABRAXAS2 mRNA CTD PMID:24136188 NCBI chr 1:187,647,078...187,672,660
Ensembl chr 1:187,647,067...187,672,655
JBrowse link
G Abtb1 ankyrin repeat and BTB domain containing 1 decreases expression EXP Glafenine results in decreased expression of ABTB1 mRNA CTD PMID:24136188 NCBI chr 4:121,299,302...121,305,667
Ensembl chr 4:121,299,304...121,305,620
JBrowse link
G Abtb2 ankyrin repeat and BTB domain containing 2 decreases expression EXP Glafenine results in decreased expression of ABTB2 mRNA CTD PMID:24136188 NCBI chr 3:89,954,726...90,108,549
Ensembl chr 3:89,954,713...90,108,548
JBrowse link
G Acaa1a acetyl-CoA acyltransferase 1A decreases expression EXP Glafenine results in decreased expression of ACAA1 mRNA CTD PMID:24136188 NCBI chr 8:119,079,401...119,088,624
Ensembl chr 8:119,079,775...119,088,624
JBrowse link
G Acaca acetyl-CoA carboxylase alpha increases expression EXP Glafenine results in increased expression of ACACA mRNA CTD PMID:24136188 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457
JBrowse link
G Acad10 acyl-CoA dehydrogenase family, member 10 decreases expression EXP Glafenine results in decreased expression of ACAD10 mRNA CTD PMID:24136188 NCBI chr12:34,901,211...34,943,973
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Acad11 acyl-CoA dehydrogenase family, member 11 decreases expression EXP Glafenine results in decreased expression of ACAD11 mRNA CTD PMID:24136188 NCBI chr 8:104,681,346...104,746,559
Ensembl chr 8:104,681,396...104,746,560
JBrowse link
G Acad9 acyl-CoA dehydrogenase family, member 9 decreases expression EXP Glafenine results in decreased expression of ACAD9 mRNA CTD PMID:24136188 NCBI chr 2:118,943,170...118,966,150
Ensembl chr 2:118,943,174...118,966,547
JBrowse link
G Acadm acyl-CoA dehydrogenase medium chain decreases expression EXP Glafenine results in decreased expression of ACADM mRNA CTD PMID:24136188 NCBI chr 2:242,858,865...242,883,036
Ensembl chr 2:242,858,865...242,883,147
JBrowse link
G Acads acyl-CoA dehydrogenase short chain decreases expression EXP Glafenine results in decreased expression of ACADS mRNA CTD PMID:24136188 NCBI chr12:41,493,650...41,502,897
Ensembl chr12:41,493,626...41,502,898
JBrowse link
G Acbd5 acyl-CoA binding domain containing 5 decreases expression EXP Glafenine results in decreased expression of ACBD5 mRNA CTD PMID:24136188 NCBI chr17:85,206,178...85,248,909
Ensembl chr17:85,206,303...85,248,215
JBrowse link
G Acer2 alkaline ceramidase 2 increases expression EXP Glafenine results in increased expression of ACER2 mRNA CTD PMID:24136188 NCBI chr 5:101,391,830...101,442,615
Ensembl chr 5:101,391,885...101,442,614
JBrowse link
G Ackr3 atypical chemokine receptor 3 increases expression EXP Glafenine results in increased expression of ACKR3 mRNA CTD PMID:24136188 NCBI chr 9:90,799,682...90,811,246
Ensembl chr 9:90,799,686...90,811,237
JBrowse link
G Acot12 acyl-CoA thioesterase 12 decreases expression EXP Glafenine results in decreased expression of ACOT12 mRNA CTD PMID:24136188 NCBI chr 2:22,986,867...23,027,538
Ensembl chr 2:22,986,626...23,027,536
JBrowse link
G Acot2 acyl-CoA thioesterase 2 decreases expression EXP Glafenine results in decreased expression of ACOT2 mRNA CTD PMID:24136188 NCBI chr 6:103,611,744...103,619,404
Ensembl chr 6:103,611,544...103,619,245
JBrowse link
G Acot4 acyl-CoA thioesterase 4 decreases expression EXP Glafenine results in decreased expression of ACOT4 mRNA CTD PMID:24136188 NCBI chr 6:103,668,699...103,674,037
Ensembl chr 6:103,668,753...103,673,917
JBrowse link
G Acox1 acyl-CoA oxidase 1 decreases expression EXP Glafenine results in decreased expression of ACOX1 mRNA CTD PMID:24136188 NCBI chr10:101,406,197...101,431,242
Ensembl chr10:101,406,197...101,431,232
JBrowse link
G Acsl1 acyl-CoA synthetase long-chain family member 1 decreases expression EXP Glafenine results in decreased expression of ACSL1 mRNA CTD PMID:24136188 NCBI chr16:45,755,246...45,821,541
Ensembl chr16:45,755,254...45,821,541
JBrowse link
G Acsm2 acyl-CoA synthetase medium-chain family member 2 decreases expression EXP Glafenine results in decreased expression of ACSM2A mRNA CTD PMID:24136188 NCBI chr 1:173,916,368...173,955,116
Ensembl chr 1:173,916,368...173,955,116
JBrowse link
G Acss2 acyl-CoA synthetase short-chain family member 2 decreases expression EXP Glafenine results in decreased expression of ACSS2 mRNA CTD PMID:24136188 NCBI chr 3:144,003,808...144,047,452
Ensembl chr 3:144,004,336...144,059,675
JBrowse link
G Actg1 actin, gamma 1 increases expression EXP Glafenine results in increased expression of ACTG1 mRNA CTD PMID:24136188 NCBI chr10:105,619,738...105,622,587
Ensembl chr10:105,619,737...105,624,232
JBrowse link
G Adck5 aarF domain containing kinase 5 decreases expression EXP Glafenine results in decreased expression of ADCK5 mRNA CTD PMID:24136188 NCBI chr 7:108,301,623...108,319,439
Ensembl chr 7:108,301,415...108,319,436
JBrowse link
G Adh4 alcohol dehydrogenase 4 (class II), pi polypeptide decreases expression EXP Glafenine results in decreased expression of ADH4 mRNA CTD PMID:24136188 NCBI chr 2:226,948,717...226,966,747
Ensembl chr 2:226,947,466...226,987,591
JBrowse link
G Adhfe1 alcohol dehydrogenase, iron containing, 1 decreases expression EXP Glafenine results in decreased expression of ADHFE1 mRNA CTD PMID:24136188 NCBI chr 5:9,705,966...9,732,580
Ensembl chr 5:9,705,970...9,732,517
JBrowse link
G Adipor2 adiponectin receptor 2 decreases expression EXP Glafenine results in decreased expression of ADIPOR2 mRNA CTD PMID:24136188 NCBI chr 4:152,524,604...152,588,848
Ensembl chr 4:152,524,623...152,559,355
JBrowse link
G Adk adenosine kinase decreases expression EXP Glafenine results in decreased expression of ADK mRNA CTD PMID:24136188 NCBI chr15:2,863,241...3,246,453
Ensembl chr15:2,863,244...3,246,510
JBrowse link
G Adss adenylosuccinate synthase decreases expression EXP Glafenine results in decreased expression of ADSS mRNA CTD PMID:24136188 NCBI chr13:89,769,240...89,799,577
Ensembl chr13:89,769,244...89,799,604
JBrowse link
G Adss1 adenylosuccinate synthase 1 decreases expression EXP Glafenine results in decreased expression of ADSSL1 mRNA CTD PMID:24136188 NCBI chr 6:131,679,795...131,702,012
Ensembl chr 6:131,679,701...131,701,998
JBrowse link
G Adtrp androgen-dependent TFPI-regulating protein decreases expression EXP Glafenine results in decreased expression of ADTRP mRNA CTD PMID:24136188 NCBI chr17:22,930,012...22,993,834
Ensembl chr17:22,930,740...22,993,826
JBrowse link
G Afm afamin decreases expression EXP Glafenine results in decreased expression of AFM mRNA CTD PMID:24136188 NCBI chr14:17,531,026...17,563,868
Ensembl chr14:17,531,024...17,563,870
JBrowse link
G Afmid arylformamidase decreases expression EXP Glafenine results in decreased expression of AFMID mRNA CTD PMID:24136188 NCBI chr10:103,046,129...103,061,718
Ensembl chr10:103,046,180...103,061,718
JBrowse link
G Agmat agmatinase decreases expression EXP Glafenine results in decreased expression of AGMAT mRNA CTD PMID:24136188 NCBI chr 5:154,043,665...154,074,278
Ensembl chr 5:154,060,151...154,074,276
JBrowse link
G Agmo alkylglycerol monooxygenase decreases expression EXP Glafenine results in decreased expression of AGMO mRNA CTD PMID:24136188 NCBI chr 6:53,986,236...54,317,838
Ensembl chr 6:53,986,292...54,317,623
JBrowse link
G Ahcy adenosylhomocysteinase decreases expression EXP Glafenine results in decreased expression of AHCY mRNA CTD PMID:24136188 NCBI chr 3:143,569,134...143,584,359
Ensembl chr 3:143,569,094...143,584,393
JBrowse link
G Aimp2 aminoacyl tRNA synthetase complex-interacting multifunctional protein 2 increases expression EXP Glafenine results in increased expression of AIMP2 mRNA CTD PMID:24136188 NCBI chr12:10,701,194...10,710,772
Ensembl chr12:10,701,194...10,710,769
JBrowse link
G Ak3 adenylate kinase 3 decreases expression EXP Glafenine results in decreased expression of AK3 mRNA CTD PMID:24136188 NCBI chr 1:226,737,472...226,764,647
Ensembl chr 1:226,739,318...226,764,625
JBrowse link
G Akr1a1 aldo-keto reductase family 1 member A1 increases expression EXP Glafenine results in increased expression of AKR1A1 mRNA CTD PMID:24136188 NCBI chr 5:130,092,945...130,130,277
Ensembl chr 5:130,092,732...130,113,674
JBrowse link
G Akr1c1 aldo-keto reductase family 1, member C1 decreases expression EXP Glafenine results in decreased expression of AKR1C1 mRNA CTD PMID:24136188 NCBI chr17:65,810,474...65,837,385
Ensembl chr17:65,810,475...65,837,326
JBrowse link
G AKR1C3l1 aldo-keto reductase family 1 member C3-like 1 decreases expression EXP Glafenine results in decreased expression of AKR1C3L1 mRNA CTD PMID:24136188 NCBI chr17:65,847,580...65,881,488
Ensembl chr17:65,835,634...65,881,488
JBrowse link
G Akr1e2 aldo-keto reductase family 1, member E2 decreases expression EXP Glafenine results in decreased expression of AKR1E2 mRNA CTD PMID:24136188 NCBI chr17:65,735,909...65,750,441
Ensembl chr17:65,735,943...65,750,441
JBrowse link
G Akr7a2 aldo-keto reductase family 7, member A2 decreases expression EXP Glafenine results in decreased expression of AKR7A2 mRNA CTD PMID:24136188 NCBI chr 5:151,552,375...151,560,914
Ensembl chr 5:151,552,343...151,560,909
JBrowse link
G Akr7a3 aldo-keto reductase family 7 member A3 decreases expression EXP Glafenine results in decreased expression of AKR7A3 mRNA CTD PMID:24136188 NCBI chr 5:151,590,968...151,601,394
Ensembl chr 5:151,584,479...151,601,394
JBrowse link
G Alas1 5'-aminolevulinate synthase 1 decreases expression EXP Glafenine results in decreased expression of ALAS1 mRNA CTD PMID:24136188 NCBI chr 8:106,876,514...106,889,852
Ensembl chr 8:106,876,514...106,889,917
JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 decreases expression EXP Glafenine results in decreased expression of ALDH1A1 mRNA CTD PMID:24136188 NCBI chr 1:218,000,470...218,152,962
Ensembl chr 1:218,042,127...218,152,961
JBrowse link
G Aldh1l1 aldehyde dehydrogenase 1 family, member L1 decreases expression EXP Glafenine results in decreased expression of ALDH1L1 mRNA CTD PMID:24136188 NCBI chr 4:123,059,989...123,106,471
Ensembl chr 4:123,060,008...123,106,465
JBrowse link
G Aldh2 aldehyde dehydrogenase 2 family member decreases expression EXP Glafenine results in decreased expression of ALDH2 mRNA CTD PMID:24136188 NCBI chr12:34,949,549...34,982,527
Ensembl chr12:34,901,219...34,982,521
JBrowse link
G Aldh3a2 aldehyde dehydrogenase 3 family, member A2 decreases expression EXP Glafenine results in decreased expression of ALDH3A2 mRNA CTD PMID:24136188 NCBI chr10:45,928,313...45,949,366
Ensembl chr10:45,908,524...45,949,281
JBrowse link
G Aldh4a1 aldehyde dehydrogenase 4 family, member A1 decreases expression EXP Glafenine results in decreased expression of ALDH4A1 mRNA CTD PMID:24136188 NCBI chr 5:151,880,002...151,905,491
Ensembl chr 5:151,830,701...151,925,345
JBrowse link
G Aldh5a1 aldehyde dehydrogenase 5 family, member A1 decreases expression EXP Glafenine results in decreased expression of ALDH5A1 mRNA CTD PMID:24136188 NCBI chr17:40,132,339...40,158,677
Ensembl chr17:40,130,883...40,158,677
JBrowse link
G Aldh6a1 aldehyde dehydrogenase 6 family, member A1 decreases expression EXP Glafenine results in decreased expression of ALDH6A1 mRNA CTD PMID:24136188 NCBI chr 6:104,077,975...104,098,636
Ensembl chr 6:104,077,979...104,098,656
JBrowse link
G Aldh9a1 aldehyde dehydrogenase 9 family, member A1 decreases expression EXP Glafenine results in decreased expression of ALDH9A1 mRNA CTD PMID:24136188 NCBI chr13:79,505,738...79,522,539
Ensembl chr13:79,505,695...79,540,568
JBrowse link
G Aldoa aldolase, fructose-bisphosphate A increases expression EXP Glafenine results in increased expression of ALDOA mRNA CTD PMID:24136188 NCBI chr 1:181,402,275...181,407,476
Ensembl chr 1:181,402,275...181,406,182
JBrowse link
G Alg12 ALG12, alpha-1,6-mannosyltransferase increases expression EXP Glafenine results in increased expression of ALG12 mRNA CTD PMID:24136188 NCBI chr 7:119,895,112...119,909,488
Ensembl chr 7:119,895,120...119,909,458
JBrowse link
G Alg2 ALG2, alpha-1,3/1,6-mannosyltransferase increases expression EXP Glafenine results in increased expression of ALG2 mRNA CTD PMID:24136188 NCBI chr 5:61,768,738...61,773,297
Ensembl chr 5:61,768,740...61,773,297
JBrowse link
G Alg3 ALG3, alpha-1,3- mannosyltransferase increases expression EXP Glafenine results in increased expression of ALG3 mRNA CTD PMID:24136188 NCBI chr11:80,300,487...80,306,014
Ensembl chr11:80,300,498...80,307,912
JBrowse link
G Amacr alpha-methylacyl-CoA racemase decreases expression EXP Glafenine results in decreased expression of AMACR mRNA CTD PMID:24136188 NCBI chr 2:59,946,158...59,958,255
Ensembl chr 2:59,946,153...59,958,255
JBrowse link
G Amigo3 adhesion molecule with Ig like domain 3 increases expression EXP Glafenine results in increased expression of AMIGO3 mRNA CTD PMID:24136188 NCBI chr 8:108,741,899...108,743,425
Ensembl chr 8:108,693,060...108,744,555
JBrowse link
G Amy2a3 amylase 2a3 decreases expression EXP Glafenine results in decreased expression of AMY1A mRNA CTD PMID:24136188 NCBI chr 2:201,317,916...201,326,487
Ensembl chr 2:201,317,920...201,326,532
JBrowse link
G Ang angiogenin decreases expression EXP Glafenine results in decreased expression of ANG mRNA CTD PMID:24136188 NCBI chr15:24,317,733...24,323,361 JBrowse link
G Angptl3 angiopoietin-like 3 decreases expression EXP Glafenine results in decreased expression of ANGPTL3 mRNA CTD PMID:24136188 NCBI chr 5:113,703,007...113,710,044
Ensembl chr 5:113,703,012...113,709,957
JBrowse link
G Ankrd24 ankyrin repeat domain 24 increases expression EXP Glafenine results in increased expression of ANKRD24 mRNA CTD PMID:24136188 NCBI chr 7:8,061,634...8,081,142
Ensembl chr 7:8,061,953...8,081,142
JBrowse link
G Ankrd46 ankyrin repeat domain 46 decreases expression EXP Glafenine results in decreased expression of ANKRD46 mRNA CTD PMID:24136188 NCBI chr 7:67,647,202...67,668,180
Ensembl chr 7:67,647,204...67,668,132
JBrowse link
G Anks4b ankyrin repeat and sterile alpha motif domain containing 4B decreases expression EXP Glafenine results in decreased expression of ANKS4B mRNA CTD PMID:24136188 NCBI chr 1:174,534,195...174,557,798
Ensembl chr 1:174,547,473...174,557,797
JBrowse link
G Antxr2 ANTXR cell adhesion molecule 2 decreases expression EXP Glafenine results in decreased expression of ANTXR2 mRNA CTD PMID:24136188 NCBI chr14:11,542,266...11,682,112
Ensembl chr14:11,541,772...11,682,094
JBrowse link
G Anxa4 annexin A4 decreases expression EXP Glafenine results in decreased expression of ANXA4 mRNA CTD PMID:24136188 NCBI chr 4:119,184,378...119,241,183
Ensembl chr 4:119,184,374...119,241,161
JBrowse link
G Apeg3 antisense paternally expressed gene 3 increases expression EXP Glafenine results in increased expression of APEG3 mRNA CTD PMID:24136188 NCBI chr 1:67,121,402...67,122,333 JBrowse link
G Apex1 apurinic/apyrimidinic endodeoxyribonuclease 1 increases expression EXP Glafenine results in increased expression of APEX1 mRNA CTD PMID:24136188 NCBI chr15:24,144,595...24,146,785
Ensembl chr15:24,144,362...24,146,785
JBrowse link
G Apmap adipocyte plasma membrane associated protein decreases expression EXP Glafenine results in decreased expression of APMAP mRNA CTD PMID:24136188 NCBI chr 3:139,409,020...139,437,296
Ensembl chr 3:139,409,022...139,437,341
JBrowse link
G Apoa2 apolipoprotein A2 decreases expression EXP Glafenine results in decreased expression of APOA2 mRNA CTD PMID:24136188 NCBI chr13:83,644,460...83,646,358
Ensembl chr13:83,644,470...83,646,355
JBrowse link
G Appbp2 amyloid beta precursor protein binding protein 2 decreases expression EXP Glafenine results in decreased expression of APPBP2 mRNA CTD PMID:24136188 NCBI chr10:70,057,774...70,099,877
Ensembl chr10:70,057,774...70,099,835
JBrowse link
G Aprt adenine phosphoribosyl transferase increases expression EXP Glafenine results in increased expression of APRT mRNA CTD PMID:24136188 NCBI chr19:50,626,436...50,628,404
Ensembl chr19:50,626,202...50,628,431
JBrowse link
G Arf4 ADP-ribosylation factor 4 increases expression EXP Glafenine results in increased expression of ARF4 mRNA CTD PMID:24136188 NCBI chr16:1,896,692...1,913,267
Ensembl chr16:1,896,546...1,913,261
JBrowse link
G Arfgap3 ADP-ribosylation factor GTPase activating protein 3 increases expression EXP Glafenine results in increased expression of ARFGAP3 mRNA CTD PMID:24136188 NCBI chr 7:114,432,873...114,479,206
Ensembl chr 7:114,432,873...114,479,208
JBrowse link
G Arfgef1 ADP ribosylation factor guanine nucleotide exchange factor 1 decreases expression EXP Glafenine results in decreased expression of ARFGEF1 mRNA CTD PMID:24136188 NCBI chr 5:8,982,061...9,076,326
Ensembl chr 5:8,981,540...9,076,326
JBrowse link
G Arfip2 ADP-ribosylation factor interacting protein 2 increases expression EXP Glafenine results in increased expression of ARFIP2 mRNA CTD PMID:24136188 NCBI chr 1:159,974,255...159,980,398
Ensembl chr 1:159,974,201...159,980,336
JBrowse link
G Arhgap1 Rho GTPase activating protein 1 increases expression EXP Glafenine results in increased expression of ARHGAP1 mRNA CTD PMID:24136188 NCBI chr 3:77,621,377...77,643,400
Ensembl chr 3:77,620,655...77,643,396
JBrowse link
G Arhgap18 Rho GTPase activating protein 18 decreases expression EXP Glafenine results in decreased expression of ARHGAP18 mRNA CTD PMID:24136188 NCBI chr 1:18,403,531...18,637,306
Ensembl chr 1:18,403,537...18,637,256
JBrowse link
G Arhgap24 Rho GTPase activating protein 24 decreases expression EXP Glafenine results in decreased expression of ARHGAP24 mRNA CTD PMID:24136188 NCBI chr14:6,800,631...7,184,001
Ensembl chr14:6,800,631...7,183,823
JBrowse link
G Arl6ip1 ADP-ribosylation factor like GTPase 6 interacting protein 1 decreases expression EXP Glafenine results in decreased expression of ARL6IP1 mRNA CTD PMID:24136188 NCBI chr 1:172,430,475...172,439,990
Ensembl chr 1:172,430,489...172,439,994
JBrowse link
G Arl6ip4 ADP-ribosylation factor like GTPase 6 interacting protein 4 increases expression EXP Glafenine results in increased expression of ARL6IP4 mRNA CTD PMID:24136188 NCBI chr12:32,479,623...32,481,768
Ensembl chr12:32,479,625...32,481,799
JBrowse link
G Armc9 armadillo repeat containing 9 increases expression EXP Glafenine results in increased expression of ARMC9 mRNA CTD PMID:24136188 NCBI chr 9:86,802,791...86,928,860
Ensembl chr 9:86,802,868...86,928,860
JBrowse link
G Armcx3 armadillo repeat containing, X-linked 3 increases expression EXP Glafenine results in increased expression of ARMCX3 mRNA CTD PMID:24136188 NCBI chr  X:97,937,115...97,942,098
Ensembl chr  X:97,936,999...97,942,098
JBrowse link
G Arpc1b actin related protein 2/3 complex, subunit 1B increases expression EXP Glafenine results in increased expression of ARPC1B mRNA CTD PMID:24136188 NCBI chr12:9,482,176...9,495,772
Ensembl chr12:9,480,831...9,495,747
JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like increases expression EXP Glafenine results in increased expression of ARPC5L mRNA CTD PMID:24136188 NCBI chr 3:22,758,710...22,767,520
Ensembl chr 3:22,759,876...22,767,538
JBrowse link
G Asl argininosuccinate lyase decreases expression EXP Glafenine results in decreased expression of ASL mRNA CTD PMID:24136188 NCBI chr12:26,659,664...26,677,136
Ensembl chr12:26,659,565...26,679,662
JBrowse link
G Ass1 argininosuccinate synthase 1 decreases expression EXP Glafenine results in decreased expression of ASS1 mRNA CTD PMID:24136188 NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
JBrowse link
G Atf4 activating transcription factor 4 increases expression EXP Glafenine results in increased expression of ATF4 mRNA CTD PMID:24136188 NCBI chr 7:111,804,135...111,806,457
Ensembl chr 7:111,804,183...111,806,446
JBrowse link
G Atg13 autophagy related 13 increases expression EXP Glafenine results in increased expression of ATG13 mRNA CTD PMID:24136188 NCBI chr 3:77,647,069...77,681,028
Ensembl chr 3:77,645,790...77,681,043
JBrowse link
G Atg16l2 autophagy related 16-like 2 increases expression EXP Glafenine results in increased expression of ATG16L2 mRNA CTD PMID:24136188 NCBI chr 1:155,687,386...155,703,419
Ensembl chr 1:155,684,564...155,703,420
JBrowse link
G Atg2b autophagy related 2B decreases expression EXP Glafenine results in decreased expression of ATG2B mRNA CTD PMID:24136188 NCBI chr 6:124,522,283...124,592,412
Ensembl chr 6:124,525,523...124,592,015
JBrowse link
G Atl2 atlastin GTPase 2 decreases expression EXP Glafenine results in decreased expression of ATL2 mRNA CTD PMID:24136188 NCBI chr 6:15,139,071...15,180,421
Ensembl chr 6:15,139,044...15,180,421
JBrowse link
G Atp11a ATPase phospholipid transporting 11A decreases expression EXP Glafenine results in decreased expression of ATP11A mRNA CTD PMID:24136188 NCBI chr16:76,657,752...76,767,640
Ensembl chr16:76,657,752...76,767,640
JBrowse link
G Atp11c ATPase phospholipid transporting 11C decreases expression EXP Glafenine results in decreased expression of ATP11C mRNA CTD PMID:24136188 NCBI chr  X:138,564,459...138,752,116
Ensembl chr  X:138,565,836...138,751,204
JBrowse link
G Atp1b1 ATPase Na+/K+ transporting subunit beta 1 decreases expression EXP Glafenine results in decreased expression of ATP1B1 mRNA CTD PMID:24136188 NCBI chr13:76,786,580...76,807,096
Ensembl chr13:76,786,578...76,807,459
JBrowse link
G Atp2a2 ATPase sarcoplasmic/endoplasmic reticulum Ca2+ transporting 2 increases expression EXP Glafenine results in increased expression of ATP2A2 mRNA CTD PMID:24136188 NCBI chr12:34,072,710...34,122,142
Ensembl chr12:34,072,683...34,122,101
JBrowse link
G Atp5mc1 ATP synthase membrane subunit c locus 1 increases expression EXP Glafenine results in increased expression of ATP5MC1 mRNA CTD PMID:24136188 NCBI chr10:81,024,056...81,026,780
Ensembl chr10:81,023,925...81,027,124
Ensembl chr10:81,023,925...81,027,124
JBrowse link
G Atrn attractin decreases expression EXP Glafenine results in decreased expression of ATRN mRNA CTD PMID:24136188 NCBI chr 3:118,110,320...118,244,326
Ensembl chr 3:118,110,229...118,244,322
JBrowse link
G Atxn2 ataxin 2 decreases expression EXP Glafenine results in decreased expression of ATXN2 mRNA CTD PMID:24136188 NCBI chr12:34,754,132...34,851,175
Ensembl chr12:34,754,137...34,851,479
JBrowse link
G Aurkaip1 aurora kinase A interacting protein 1 increases expression EXP Glafenine results in increased expression of AURKAIP1 mRNA CTD PMID:24136188 NCBI chr 5:166,435,177...166,436,888
Ensembl chr 5:166,417,508...166,436,882
JBrowse link
G B2m beta-2 microglobulin decreases expression EXP Glafenine results in decreased expression of B2M mRNA CTD PMID:24136188 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766
JBrowse link
G B4galt1 beta-1,4-galactosyltransferase 1 increases expression EXP Glafenine results in increased expression of B4GALT1 mRNA CTD PMID:24136188 NCBI chr 5:55,935,614...55,982,461
Ensembl chr 5:55,935,615...55,982,461
JBrowse link
G B4gat1 beta-1,4-glucuronyltransferase 1 decreases expression EXP Glafenine results in decreased expression of B4GAT1 mRNA CTD PMID:24136188 NCBI chr 1:202,343,268...202,345,490
Ensembl chr 1:202,343,240...202,346,065
JBrowse link
G Baat bile acid CoA:amino acid N-acyltransferase decreases expression EXP Glafenine results in decreased expression of BAAT mRNA CTD PMID:24136188 NCBI chr 5:63,851,668...63,860,641
Ensembl chr 5:63,850,705...63,860,685
JBrowse link
G Babam1 BRISC and BRCA1 A complex member 1 increases expression EXP Glafenine results in increased expression of BABAM1 mRNA CTD PMID:24136188 NCBI chr16:18,068,830...18,074,938
Ensembl chr16:18,068,884...18,074,923
JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 increases expression EXP Glafenine results in increased expression of BASP1 mRNA CTD PMID:24136188 NCBI chr 2:75,816,130...75,863,801
Ensembl chr 2:75,816,122...75,864,043
JBrowse link
G Bbln bublin coiled coil protein increases expression EXP Glafenine results in increased expression of BBLN mRNA CTD PMID:24136188 NCBI chr 3:15,674,577...15,677,393
Ensembl chr 3:15,674,580...15,677,374
JBrowse link
G Bbox1 gamma-butyrobetaine hydroxylase 1 decreases expression EXP Glafenine results in decreased expression of BBOX1 mRNA CTD PMID:24136188 NCBI chr 3:96,822,654...96,871,786
Ensembl chr 3:96,822,655...96,871,458
JBrowse link
G Bbs2 Bardet-Biedl syndrome 2 decreases expression EXP Glafenine results in decreased expression of BBS2 mRNA CTD PMID:24136188 NCBI chr19:10,909,653...10,944,998
Ensembl chr19:10,909,619...10,944,993
JBrowse link
G Bcl3 BCL3, transcription coactivator increases expression EXP Glafenine results in increased expression of BCL3 mRNA CTD PMID:24136188 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607
JBrowse link
G Bet1l Bet1 golgi vesicular membrane trafficking protein-like increases expression EXP Glafenine results in increased expression of BET1L mRNA CTD PMID:24136188 NCBI chr 1:195,930,165...195,935,072
Ensembl chr 1:195,931,411...195,935,040
JBrowse link
G Bhlhe40 basic helix-loop-helix family, member e40 increases expression EXP Glafenine results in increased expression of BHLHE40 mRNA CTD PMID:24136188 NCBI chr 4:141,618,453...141,624,154
Ensembl chr 4:141,618,476...141,624,774
JBrowse link
G Bhmt betaine-homocysteine S-methyltransferase decreases expression EXP Glafenine results in decreased expression of BHMT mRNA CTD PMID:24136188 NCBI chr 2:24,859,871...24,879,449
Ensembl chr 2:24,859,873...24,879,742
JBrowse link
G Bhmt2 betaine-homocysteine S-methyltransferase 2 decreases expression EXP Glafenine results in decreased expression of BHMT2 mRNA CTD PMID:24136188 NCBI chr 2:24,895,525...24,912,475
Ensembl chr 2:24,895,533...24,912,475
JBrowse link
G Bloc1s5 biogenesis of lysosomal organelles complex 1 subunit 5 decreases expression EXP Glafenine results in decreased expression of BLOC1S5 mRNA CTD PMID:24136188 NCBI chr17:26,171,965...26,197,276
Ensembl chr17:26,172,018...26,197,251
JBrowse link
G Blvrb biliverdin reductase B decreases expression EXP Glafenine results in decreased expression of BLVRB mRNA CTD PMID:24136188 NCBI chr 1:82,738,646...82,756,312
Ensembl chr 1:82,738,695...82,770,375
JBrowse link
G Bnip1 BCL2 interacting protein 1 increases expression EXP Glafenine results in increased expression of BNIP1 mRNA CTD PMID:24136188 NCBI chr10:16,386,876...16,399,124
Ensembl chr10:16,386,841...16,399,157
JBrowse link
G Bnip3l BCL2 interacting protein 3 like decreases expression EXP Glafenine results in decreased expression of BNIP3L mRNA CTD PMID:24136188 NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
JBrowse link
G Bola3 bolA family member 3 increases expression EXP Glafenine results in increased expression of BOLA3 mRNA CTD PMID:24136188 NCBI chr 4:115,853,350...115,862,797
Ensembl chr 4:115,853,350...115,862,797
JBrowse link
G Bop1 BOP1 ribosomal biogenesis factor increases expression EXP Glafenine results in increased expression of BOP1 mRNA CTD PMID:24136188 NCBI chr 7:108,172,062...108,195,875
Ensembl chr 7:108,172,066...108,195,931
JBrowse link
G Borcs7 BLOC-1 related complex subunit 7 increases expression EXP Glafenine results in increased expression of BORCS7 mRNA CTD PMID:24136188 NCBI chr 1:245,564,347...245,578,182
Ensembl chr 1:245,564,369...245,579,343
JBrowse link
G Bphl biphenyl hydrolase like decreases expression EXP Glafenine results in decreased expression of BPHL mRNA CTD PMID:24136188 NCBI chr17:30,800,939...30,837,277
Ensembl chr17:30,799,629...30,837,288
JBrowse link
G Brd3 bromodomain containing 3 decreases expression EXP Glafenine results in decreased expression of BRD3 mRNA CTD PMID:24136188 NCBI chr 3:10,773,163...10,829,675
Ensembl chr 3:10,775,272...10,829,577
JBrowse link
G Brix1 biogenesis of ribosomes BRX1 increases expression EXP Glafenine results in increased expression of BRIX1 mRNA CTD PMID:24136188 NCBI chr 2:59,450,608...59,461,486
Ensembl chr 2:59,450,614...59,461,495
JBrowse link
G Btbd1 BTB domain containing 1 decreases expression EXP Glafenine results in decreased expression of BTBD1 mRNA CTD PMID:24136188 NCBI chr 1:135,734,549...135,773,067
Ensembl chr 1:135,734,589...135,771,981
JBrowse link
G Btbd11 BTB domain containing 11 decreases expression EXP Glafenine results in decreased expression of BTBD11 mRNA CTD PMID:24136188 NCBI chr 7:18,035,151...18,310,718
Ensembl chr 7:18,036,083...18,310,834
JBrowse link
G Btbd6 BTB domain containing 6 decreases expression EXP Glafenine results in decreased expression of BTBD6 mRNA CTD PMID:24136188 NCBI chr 6:132,058,094...132,060,603
Ensembl chr 6:132,058,096...132,060,587
JBrowse link
G Btg2 BTG anti-proliferation factor 2 increases expression EXP Glafenine results in increased expression of BTG2 mRNA CTD PMID:24136188 NCBI chr13:45,531,881...45,535,642
Ensembl chr13:45,531,925...45,535,628
JBrowse link
G Btg3 BTG anti-proliferation factor 3 increases expression EXP Glafenine results in increased expression of BTG3 mRNA CTD PMID:24136188 NCBI chr11:17,030,156...17,046,069
Ensembl chr11:17,030,160...17,046,170
JBrowse link
G Bysl bystin-like increases expression EXP Glafenine results in increased expression of BYSL mRNA CTD PMID:24136188 NCBI chr 9:13,382,806...13,392,557
Ensembl chr 9:13,382,557...13,394,339
JBrowse link
G C1qbp complement C1q binding protein increases expression EXP Glafenine results in increased expression of C1QBP mRNA CTD PMID:24136188 NCBI chr10:55,699,954...55,704,605
Ensembl chr10:55,699,954...55,704,649
JBrowse link
G C4bpb complement component 4 binding protein, beta increases expression EXP Glafenine results in increased expression of C4BPB mRNA CTD PMID:24136188 NCBI chr13:42,120,798...42,131,515
Ensembl chr13:42,120,798...42,131,817
JBrowse link
G C5 complement C5 increases expression EXP Glafenine results in increased expression of C5 mRNA CTD PMID:24136188 NCBI chr 3:18,270,696...18,361,994
Ensembl chr 3:18,270,696...18,361,994
JBrowse link
G C9 complement C9 increases expression EXP Glafenine results in increased expression of C9 mRNA CTD PMID:24136188 NCBI chr 2:55,573,094...55,621,345
Ensembl chr 2:55,572,992...55,621,338
JBrowse link
G Ca14 carbonic anhydrase 14 decreases expression EXP Glafenine results in decreased expression of CAR14 mRNA CTD PMID:24136188 NCBI chr 2:183,442,263...183,449,207
Ensembl chr 2:183,441,667...183,449,693
JBrowse link
G Ca3 carbonic anhydrase 3 decreases expression EXP Glafenine results in decreased expression of CAR3 mRNA CTD PMID:24136188 NCBI chr 2:86,770,418...86,780,011
Ensembl chr 2:86,770,420...86,784,280
JBrowse link
G Ca5a carbonic anhydrase 5A decreases expression EXP Glafenine results in decreased expression of CAR5A mRNA CTD PMID:24136188 NCBI chr19:49,973,092...50,002,948
Ensembl chr19:49,973,107...50,002,906
JBrowse link
G Ca8 carbonic anhydrase 8 increases expression EXP Glafenine results in increased expression of CAR8 mRNA CTD PMID:24136188 NCBI chr 5:21,302,940...21,402,395
Ensembl chr 5:21,305,383...21,402,374
JBrowse link
G Cad carbamoyl-phosphate synthetase 2, aspartate transcarbamylase, and dihydroorotase increases expression EXP Glafenine results in increased expression of CAD mRNA CTD PMID:24136188 NCBI chr 6:25,292,133...25,315,176
Ensembl chr 6:25,292,133...25,319,861
JBrowse link
G Calm1 calmodulin 1 increases expression EXP Glafenine results in increased expression of CALM1 mRNA CTD PMID:24136188 NCBI chr 6:119,487,691...119,495,759
Ensembl chr 6:119,487,621...119,498,227
JBrowse link
G Calr calreticulin increases expression EXP Glafenine results in increased expression of CALR mRNA CTD PMID:24136188 NCBI chr19:23,308,525...23,313,420
Ensembl chr19:23,308,351...23,313,414
JBrowse link
G Calu calumenin increases expression EXP Glafenine results in increased expression of CALU mRNA CTD PMID:24136188 NCBI chr 4:57,949,086...57,976,589
Ensembl chr 4:57,948,997...57,976,593
JBrowse link
G Caprin1 cell cycle associated protein 1 decreases expression EXP Glafenine results in decreased expression of CAPRIN1 mRNA CTD PMID:24136188 NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
JBrowse link
G Cars cysteinyl-tRNA synthetase increases expression EXP Glafenine results in increased expression of CARS mRNA CTD PMID:24136188 NCBI chr 1:198,753,689...198,796,016
Ensembl chr 1:198,753,691...198,795,941
JBrowse link
G Cars2 cysteinyl-tRNA synthetase 2, mitochondrial decreases expression EXP Glafenine results in decreased expression of CARS2 mRNA CTD PMID:24136188 NCBI chr16:77,945,468...77,987,163
Ensembl chr16:77,950,008...77,987,772
JBrowse link
G Cat catalase decreases expression EXP Glafenine results in decreased expression of CAT mRNA CTD PMID:24136188 NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
JBrowse link
G Cav2 caveolin 2 increases expression EXP Glafenine results in increased expression of CAV2 mRNA CTD PMID:24136188 NCBI chr 4:45,616,766...45,624,144
Ensembl chr 4:45,616,712...45,624,244
JBrowse link
G Cbr4 carbonyl reductase 4 decreases expression EXP Glafenine results in decreased expression of CBR4 mRNA CTD PMID:24136188 NCBI chr16:28,629,928...28,684,230
Ensembl chr16:28,617,224...28,645,712
JBrowse link
G Ccdc125 coiled-coil domain containing 125 increases expression EXP Glafenine results in increased expression of CCDC125 mRNA CTD PMID:24136188 NCBI chr 2:31,809,120...31,835,538
Ensembl chr 2:31,809,228...31,850,152
JBrowse link
G Ccdc134 coiled-coil domain containing 134 increases expression EXP Glafenine results in increased expression of CCDC134 mRNA CTD PMID:24136188 NCBI chr 7:113,644,557...113,659,050
Ensembl chr 7:113,644,639...113,659,050
JBrowse link
G Ccdc167 coiled-coil domain containing 167 increases expression EXP Glafenine results in increased expression of CCDC167 mRNA CTD PMID:24136188 NCBI chr20:7,763,927...7,782,090
Ensembl chr20:7,751,782...7,781,613
JBrowse link
G Ccdc28a coiled-coil domain containing 28A decreases expression EXP Glafenine results in decreased expression of CCDC28A mRNA CTD PMID:24136188 NCBI chr 1:12,857,668...12,872,944
Ensembl chr 1:12,857,666...12,873,003
JBrowse link
G Ccdc86 coiled-coil domain containing 86 increases expression EXP Glafenine results in increased expression of CCDC86 mRNA CTD PMID:24136188 NCBI chr 1:207,590,946...207,596,527
Ensembl chr 1:207,590,168...207,596,544
JBrowse link
G Ccng2 cyclin G2 decreases expression EXP Glafenine results in decreased expression of CCNG2 mRNA CTD PMID:24136188 NCBI chr14:14,804,321...14,812,819
Ensembl chr14:14,804,322...14,812,830
JBrowse link
G Ccni cyclin I decreases expression EXP Glafenine results in decreased expression of CCNI mRNA CTD PMID:24136188 NCBI chr14:14,879,698...14,902,510
Ensembl chr14:14,879,717...14,902,510
JBrowse link
G Cd2bp2 Cd2 (cytoplasmic tail) binding protein 2 increases expression EXP Glafenine results in increased expression of CD2BP2 mRNA CTD PMID:24136188 NCBI chr 1:181,809,399...181,815,269
Ensembl chr 1:181,809,406...181,813,448
JBrowse link
G Cd48 Cd48 molecule increases expression EXP Glafenine results in increased expression of CD48 mRNA CTD PMID:24136188 NCBI chr13:84,184,884...84,209,144
Ensembl chr13:84,185,532...84,209,142
JBrowse link
G Cd59 CD59 molecule decreases expression EXP Glafenine results in decreased expression of CD59 mRNA CTD PMID:24136188 NCBI chr 3:90,459,085...90,477,571
Ensembl chr 3:90,459,162...90,478,847
JBrowse link
G Cdadc1 cytidine and dCMP deaminase domain containing 1 decreases expression EXP Glafenine results in decreased expression of CDADC1 mRNA CTD PMID:24136188 NCBI chr15:33,726,590...33,755,611
Ensembl chr15:33,723,435...33,755,576
JBrowse link
G Cdc42se1 CDC42 small effector 1 increases expression EXP Glafenine results in increased expression of CDC42SE1 mRNA CTD PMID:24136188 NCBI chr 2:182,805,691...182,813,520
Ensembl chr 2:182,804,925...182,814,028
JBrowse link
G Cdc5l cell division cycle 5-like decreases expression EXP Glafenine results in decreased expression of CDC5L mRNA CTD PMID:24136188 NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
JBrowse link
G Cdh2 cadherin 2 decreases expression EXP Glafenine results in decreased expression of CDH2 mRNA CTD PMID:24136188 NCBI chr18:7,776,704...7,990,934
Ensembl chr18:7,776,704...7,990,167
JBrowse link
G Cdip1 cell death-inducing p53 target 1 decreases expression EXP Glafenine results in decreased expression of CDIP1 mRNA CTD PMID:24136188 NCBI chr10:10,773,538...10,796,979
Ensembl chr10:10,774,705...10,796,980
JBrowse link
G Cdk2ap1 cyclin-dependent kinase 2 associated protein 1 increases expression EXP Glafenine results in increased expression of CDK2AP1 mRNA CTD PMID:24136188 NCBI chr12:32,249,783...32,258,483
Ensembl chr12:32,249,747...32,258,479
JBrowse link
G Cdk2ap2 cyclin-dependent kinase 2 associated protein 2 increases expression EXP Glafenine results in increased expression of CDK2AP2 mRNA CTD PMID:24136188 NCBI chr 1:201,391,056...201,393,137
Ensembl chr 1:201,391,466...201,393,137
JBrowse link
G Cdk4 cyclin-dependent kinase 4 increases expression EXP Glafenine results in increased expression of CDK4 mRNA CTD PMID:24136188 NCBI chr 7:62,885,647...62,889,562
Ensembl chr 7:62,883,105...62,942,403
JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression EXP Glafenine results in increased expression of CDKN1A mRNA CTD PMID:24136188 NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B decreases expression EXP Glafenine results in decreased expression of CDKN1B mRNA CTD PMID:24136188 NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
JBrowse link
G Cdkn3 cyclin-dependent kinase inhibitor 3 decreases expression EXP Glafenine results in decreased expression of CDKN3 mRNA CTD PMID:24136188 NCBI chr15:20,022,522...20,033,948
Ensembl chr15:20,022,664...20,033,945
JBrowse link
G Cdo1 cysteine dioxygenase type 1 decreases expression EXP Glafenine results in decreased expression of CDO1 mRNA CTD PMID:24136188 NCBI chr18:39,432,473...39,447,253
Ensembl chr18:39,432,474...39,447,296
JBrowse link
G Ceacam1 CEA cell adhesion molecule 1 decreases expression EXP Glafenine results in decreased expression of CEACAM1 mRNA CTD PMID:24136188 NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
JBrowse link
G Cebpd CCAAT/enhancer binding protein delta increases expression EXP Glafenine results in increased expression of CEBPD mRNA CTD PMID:24136188 NCBI chr11:84,764,670...84,765,808
Ensembl chr11:84,764,565...84,765,829
JBrowse link
G Cemip2 cell migration inducing hyaluronidase 2 increases expression EXP Glafenine results in increased expression of CEMIP2 mRNA CTD PMID:24136188 NCBI chr 1:219,330,295...219,407,760
Ensembl chr 1:219,337,985...219,407,760
JBrowse link
G Cept1 choline/ethanolamine phosphotransferase 1 decreases expression EXP Glafenine results in decreased expression of CEPT1 mRNA CTD PMID:24136188 NCBI chr 2:193,994,220...194,036,141
Ensembl chr 2:193,993,447...194,035,578
JBrowse link
G Ces1d carboxylesterase 1D decreases expression EXP Glafenine results in decreased expression of CES1D mRNA CTD PMID:24136188 NCBI chr19:13,873,490...13,912,035
Ensembl chr19:13,796,623...13,912,035
JBrowse link
G Chac2 ChaC glutathione specific gamma-glutamylcyclotransferase 2 decreases expression EXP Glafenine results in decreased expression of CHAC2 mRNA CTD PMID:24136188 NCBI chr14:104,720,754...104,728,305
Ensembl chr14:104,720,758...104,728,301
JBrowse link
G Chchd6 coiled-coil-helix-coiled-coil-helix domain containing 6 increases expression EXP Glafenine results in increased expression of CHCHD6 mRNA CTD PMID:24136188 NCBI chr 4:121,803,501...122,024,209
Ensembl chr 4:121,792,717...122,024,216
JBrowse link
G Chid1 chitinase domain containing 1 increases expression EXP Glafenine results in increased expression of CHID1 mRNA CTD PMID:24136188 NCBI chr 1:196,594,357...196,629,700
Ensembl chr 1:196,587,509...196,629,606
JBrowse link
G Chmp4c charged multivesicular body protein 4C decreases expression EXP Glafenine results in decreased expression of CHMP4C mRNA CTD PMID:24136188 NCBI chr 2:91,391,729...91,428,652
Ensembl chr 2:91,388,530...91,428,668
JBrowse link
G Chpf2 chondroitin polymerizing factor 2 increases expression EXP Glafenine results in increased expression of CHPF2 mRNA CTD PMID:24136188 NCBI chr 4:10,578,470...10,585,940
Ensembl chr 4:10,580,462...10,585,916
JBrowse link
G Cic capicua transcriptional repressor increases expression EXP Glafenine results in increased expression of CIC mRNA CTD PMID:24136188 NCBI chr 1:80,853,920...80,880,537
Ensembl chr 1:80,853,920...80,880,532
JBrowse link
G Cinp cyclin-dependent kinase 2-interacting protein increases expression EXP Glafenine results in increased expression of CINP mRNA CTD PMID:24136188 NCBI chr 6:129,878,618...129,899,575
Ensembl chr 6:129,885,570...129,899,480
JBrowse link
G Cisd2 CDGSH iron sulfur domain 2 increases expression EXP Glafenine results in increased expression of CISD2 mRNA CTD PMID:24136188 NCBI chr 2:223,828,937...223,853,768
Ensembl chr 2:223,828,937...223,868,946
JBrowse link
G Cks1b CDC28 protein kinase regulatory subunit 1B increases expression EXP Glafenine results in increased expression of CKS1B mRNA CTD PMID:24136188 NCBI chr 2:174,833,025...174,837,614
Ensembl chr 2:174,833,050...174,837,636
JBrowse link
G Clcn4 chloride voltage-gated channel 4 decreases expression EXP Glafenine results in decreased expression of CLCN4 mRNA CTD PMID:24136188 NCBI chr  X:23,729,194...23,795,391
Ensembl chr  X:23,729,338...23,793,238
JBrowse link
G Clic1 chloride intracellular channel 1 increases expression EXP Glafenine results in increased expression of CLIC1 mRNA CTD PMID:24136188 NCBI chr20:3,764,867...3,773,711
Ensembl chr20:3,761,461...3,773,712
JBrowse link
G Clpx caseinolytic mitochondrial matrix peptidase chaperone subunit X decreases expression EXP Glafenine results in decreased expression of CLPX mRNA CTD PMID:24136188 NCBI chr 8:65,805,460...65,845,643
Ensembl chr 8:65,805,511...65,845,082
JBrowse link
G Cmbl carboxymethylenebutenolidase homolog decreases expression EXP Glafenine results in decreased expression of CMBL mRNA CTD PMID:24136188 NCBI chr 2:82,569,257...82,591,007
Ensembl chr 2:82,571,888...82,591,009
JBrowse link
G Cmtr1 cap methyltransferase 1 decreases expression EXP Glafenine results in decreased expression of CMTR1 mRNA CTD PMID:24136188 NCBI chr20:7,722,729...7,782,579
Ensembl chr20:7,709,713...7,766,302
JBrowse link
G Cnn2 calponin 2 increases expression EXP Glafenine results in increased expression of CNN2 mRNA CTD PMID:24136188 NCBI chr 7:9,712,505...9,719,711
Ensembl chr 7:9,712,516...9,719,656
JBrowse link
G Cnppd1 cyclin Pas1/PHO80 domain containing 1 decreases expression EXP Glafenine results in decreased expression of CNPPD1 mRNA CTD PMID:24136188 NCBI chr 9:76,633,475...76,640,164
Ensembl chr 9:76,633,477...76,640,188
JBrowse link
G Cnpy2 canopy FGF signaling regulator 2 increases expression EXP Glafenine results in increased expression of CNPY2 mRNA CTD PMID:24136188 NCBI chr 7:748,877...754,352
Ensembl chr 7:749,008...755,519
JBrowse link
G Cnpy3 canopy FGF signaling regulator 3 increases expression EXP Glafenine results in increased expression of CNPY3 mRNA CTD PMID:24136188 NCBI chr 9:14,233,478...14,247,847
Ensembl chr 9:14,233,428...14,247,831
JBrowse link
G Coasy Coenzyme A synthase decreases expression EXP Glafenine results in decreased expression of COASY mRNA CTD PMID:24136188 NCBI chr10:86,014,566...86,018,849
Ensembl chr10:86,014,597...86,018,841
JBrowse link
G Cog3 component of oligomeric golgi complex 3 increases expression EXP Glafenine results in increased expression of COG3 mRNA CTD PMID:24136188 NCBI chr15:51,020,808...51,071,288
Ensembl chr15:51,020,813...51,070,570
JBrowse link
G Cog4 component of oligomeric golgi complex 4 decreases expression EXP Glafenine results in decreased expression of COG4 mRNA CTD PMID:24136188 NCBI chr19:38,820,478...38,854,803
Ensembl chr19:38,820,501...38,854,796
JBrowse link
G Col18a1 collagen type XVIII alpha 1 chain increases expression EXP Glafenine results in increased expression of COL18A1 mRNA CTD PMID:24136188 NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
JBrowse link
G Col4a1 collagen type IV alpha 1 chain increases expression EXP Glafenine results in increased expression of COL4A1 mRNA CTD PMID:24136188 NCBI chr16:78,183,533...78,294,412
Ensembl chr16:78,183,533...78,294,412
JBrowse link
G Copa COPI coat complex subunit alpha increases expression EXP Glafenine results in increased expression of COPA mRNA CTD PMID:24136188 NCBI chr13:84,546,483...84,586,879
Ensembl chr13:84,545,943...84,586,874
JBrowse link
G Cope COPI coat complex subunit epsilon increases expression EXP Glafenine results in increased expression of COPE mRNA CTD PMID:24136188 NCBI chr16:19,114,871...19,125,527
Ensembl chr16:19,114,871...19,128,907
JBrowse link
G Copg1 COPI coat complex subunit gamma 1 increases expression EXP Glafenine results in increased expression of COPG1 mRNA CTD PMID:24136188 NCBI chr 4:120,366,540...120,392,502
Ensembl chr 4:120,366,542...120,415,616
JBrowse link
G Copg2 COPI coat complex subunit gamma 2 decreases expression EXP Glafenine results in decreased expression of COPG2 mRNA CTD PMID:24136188 NCBI chr 4:59,366,086...59,501,591
Ensembl chr 4:59,366,086...59,501,618
JBrowse link
G Copz1 COPI coat complex subunit zeta 1 increases expression EXP Glafenine results in increased expression of COPZ1 mRNA CTD PMID:24136188 NCBI chr 7:134,409,523...134,435,661
Ensembl chr 7:134,409,799...134,435,662
JBrowse link
G Copz2 COPI coat complex subunit zeta 2 increases expression EXP Glafenine results in increased expression of COPZ2 mRNA CTD PMID:24136188 NCBI chr10:81,832,441...81,845,514
Ensembl chr10:81,832,418...81,845,514
JBrowse link
G Coq10a coenzyme Q10A decreases expression EXP Glafenine results in decreased expression of COQ10A mRNA CTD PMID:24136188 NCBI chr 7:792,089...798,392
Ensembl chr 7:792,089...800,161
JBrowse link
G Coq10b coenzyme Q10B increases expression EXP Glafenine results in increased expression of COQ10B mRNA CTD PMID:24136188 NCBI chr 9:56,553,751...56,573,671
Ensembl chr 9:56,553,758...56,573,663
JBrowse link
G Coq8a coenzyme Q8A decreases expression EXP Glafenine results in decreased expression of COQ8A mRNA CTD PMID:24136188 NCBI chr13:91,904,731...91,933,588
Ensembl chr13:91,904,739...91,931,431
JBrowse link
G Cotl1 coactosin-like F-actin binding protein 1 increases expression EXP Glafenine results in increased expression of COTL1 mRNA CTD PMID:24136188 NCBI chr19:47,871,689...47,906,010
Ensembl chr19:47,871,694...47,911,689
JBrowse link
G Cox5a cytochrome c oxidase subunit 5A decreases expression EXP Glafenine results in decreased expression of COX5A mRNA CTD PMID:24136188 NCBI chr 8:57,922,374...57,933,781
Ensembl chr 8:57,922,290...57,933,781
JBrowse link
G Cox5b cytochrome c oxidase subunit 5B increases expression EXP Glafenine results in increased expression of COX5B mRNA CTD PMID:24136188 NCBI chr 9:38,921,980...38,923,806
Ensembl chr 9:38,921,967...38,925,052
JBrowse link
G Cp ceruloplasmin increases expression EXP Glafenine results in increased expression of CP mRNA CTD PMID:24136188 NCBI chr 2:102,439,433...102,498,075
Ensembl chr 2:102,439,624...102,498,075
JBrowse link
G Cpne3 copine 3 decreases expression EXP Glafenine results in decreased expression of CPNE3 mRNA CTD PMID:24136188 NCBI chr 5:33,014,658...33,064,004
Ensembl chr 5:33,016,307...33,063,934
JBrowse link
G Cpne8 copine 8 increases expression EXP Glafenine results in increased expression of CPNE8 mRNA CTD PMID:24136188 NCBI chr 7:121,615,293...121,789,507
Ensembl chr 7:121,615,294...121,790,377
JBrowse link
G Cpped1 calcineurin-like phosphoesterase domain containing 1 decreases expression EXP Glafenine results in decreased expression of CPPED1 mRNA CTD PMID:24136188 NCBI chr10:3,701,522...3,821,050
Ensembl chr10:3,701,459...3,821,054
JBrowse link
G Cpq carboxypeptidase Q decreases expression EXP Glafenine results in decreased expression of PGCP mRNA CTD PMID:24136188 NCBI chr 7:64,264,025...64,830,867
Ensembl chr 7:64,264,081...64,724,546
JBrowse link
G Cps1 carbamoyl-phosphate synthase 1 decreases expression EXP Glafenine results in decreased expression of CPS1 mRNA CTD PMID:24136188 NCBI chr 9:68,614,153...68,737,037
Ensembl chr 9:68,614,153...68,737,033
JBrowse link
G Cpt2 carnitine palmitoyltransferase 2 decreases expression EXP Glafenine results in decreased expression of CPT2 mRNA CTD PMID:24136188 NCBI chr 5:122,664,677...122,682,126
Ensembl chr 5:122,664,677...122,682,095
JBrowse link
G Crat carnitine O-acetyltransferase decreases expression EXP Glafenine results in decreased expression of CRAT mRNA CTD PMID:24136188 NCBI chr 3:13,675,684...13,689,282
Ensembl chr 3:13,675,684...13,689,255
JBrowse link
G Crbn cereblon decreases expression EXP Glafenine results in decreased expression of CRBN mRNA CTD PMID:24136188 NCBI chr 4:139,701,154...139,719,949
Ensembl chr 4:139,701,094...139,719,938
JBrowse link
G Creb3l3 cAMP responsive element binding protein 3-like 3 decreases expression EXP Glafenine results in decreased expression of CREB3L3 mRNA CTD PMID:24136188 NCBI chr 7:8,622,614...8,631,053
Ensembl chr 7:8,622,614...8,631,048
JBrowse link
G Crebzf CREB/ATF bZIP transcription factor decreases expression EXP Glafenine results in decreased expression of CREBZF mRNA CTD PMID:24136188 NCBI chr 1:144,416,864...144,423,540
Ensembl chr 1:144,417,446...144,428,553
JBrowse link
G Creld2 cysteine-rich with EGF-like domains 2 increases expression EXP Glafenine results in increased expression of CRELD2 mRNA CTD PMID:24136188 NCBI chr 7:119,909,626...119,916,556
Ensembl chr 7:119,909,633...119,916,543
JBrowse link
G Crem cAMP responsive element modulator decreases expression EXP Glafenine results in decreased expression of CREM mRNA CTD PMID:24136188 NCBI chr17:54,238,889...54,305,989
Ensembl chr17:54,239,030...54,305,989
JBrowse link
G Crls1 cardiolipin synthase 1 decreases expression EXP Glafenine results in decreased expression of CRLS1 mRNA CTD PMID:24136188 NCBI chr 3:120,119,822...120,138,674
Ensembl chr 3:120,119,852...120,138,655
JBrowse link
G Crot carnitine O-octanoyltransferase decreases expression EXP Glafenine results in decreased expression of CROT mRNA CTD PMID:24136188 NCBI chr 4:25,068,270...25,133,111
Ensembl chr 4:25,080,587...25,133,109
JBrowse link
G Crybg2 crystallin beta-gamma domain containing 2 decreases expression EXP Glafenine results in decreased expression of CRYBG2 mRNA CTD PMID:24136188 NCBI chr 5:146,286,406...146,318,417
Ensembl chr 5:146,286,925...146,323,666
JBrowse link
G Cryl1 crystallin, lambda 1 decreases expression EXP Glafenine results in decreased expression of CRYL1 mRNA CTD PMID:24136188 NCBI chr15:31,427,011...31,545,997
Ensembl chr15:31,427,054...31,545,997
JBrowse link
G Crym crystallin, mu decreases expression EXP Glafenine results in decreased expression of CRYM mRNA CTD PMID:24136188 NCBI chr 1:174,560,423...174,575,660
Ensembl chr 1:174,560,416...174,575,633
JBrowse link
G Cryz crystallin zeta decreases expression EXP Glafenine results in decreased expression of CRYZ mRNA CTD PMID:24136188 NCBI chr 2:243,552,037...243,580,369
Ensembl chr 2:243,552,119...243,579,758
JBrowse link
G Csf1 colony stimulating factor 1 increases expression EXP Glafenine results in increased expression of CSF1 mRNA CTD PMID:24136188 NCBI chr 2:195,377,215...195,396,608