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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1617608
Species: Mus musculus
RGD Object: Gene
Symbol: Cxcl15
Name: C-X-C motif chemokine ligand 15
Acc ID: CHEBI:3638
Term: chloroquine
Definition: An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chemical ID: MESH:D002738
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Cxcl15multiple interactionsEXP 6480464CTDChloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of CXCL8]PMID:22595112
Cxcl15increases expressionISOCXCL8 (Homo sapiens)6480464CTDChloroquine results in increased expression of CXCL8 mRNAPMID:15139008 PMID:29594315
Cxcl15multiple interactionsISOCXCL8 (Homo sapiens)6480464CTD[Chloroquine co-treated with lipopolysaccharide, E. coli O26-B6] results in decreased expression of CXCL8 mRNA; Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CXCL8 mRNA]PMID:15139008 PMID:25915936 PMID:29594315
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