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G
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Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ACTA2 protein]; 3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]
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CTD |
PMID:30677399 PMID:38477077 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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G
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Adamts5
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ADAM metallopeptidase with thrombospondin type 1 motif, 5
|
multiple interactions
|
EXP
|
3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]]
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CTD |
PMID:34122080 |
|
NCBI chr11:25,000,627...25,047,205
Ensembl chr11:25,000,637...25,047,205
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G
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Aifm1
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apoptosis inducing factor, mitochondria associated 1
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increases expression
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EXP
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3-methyladenine results in increased expression of AIFM1 protein
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CTD |
PMID:16497721 |
|
NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256
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G
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Akt1
|
AKT serine/threonine kinase 1
|
decreases phosphorylation multiple interactions
|
ISO
|
3-methyladenine results in decreased phosphorylation of AKT1 protein 3-methyladenine inhibits the reaction [isobavachin results in decreased phosphorylation of AKT1 protein] 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]
|
CTD |
PMID:16882451 PMID:32043704 PMID:39154867 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G
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Apaf1
|
apoptotic peptidase activating factor 1
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased expression of APAF1 protein]]
|
CTD |
PMID:35149085 |
|
NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540
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|
G
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Apod
|
apolipoprotein D
|
affects localization
|
ISO
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3-methyladenine affects the localization of APOD protein
|
CTD |
PMID:28182653 |
|
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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|
G
|
App
|
amyloid beta precursor protein
|
multiple interactions
|
ISO
|
[Hydrogen Peroxide co-treated with 3-methyladenine] results in increased expression of APP protein
|
CTD |
PMID:23726866 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G
|
Atg4a
|
autophagy related 4A, cysteine peptidase
|
decreases expression
|
ISO
|
3-methyladenine results in decreased expression of ATG4A mRNA
|
CTD |
PMID:21681844 |
|
NCBI chr X:104,665,345...104,765,271
Ensembl chr X:104,665,345...104,765,268
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G
|
Atg4b
|
autophagy related 4B, cysteine peptidase
|
decreases expression
|
ISO
|
3-methyladenine results in decreased expression of ATG4B mRNA
|
CTD |
PMID:21681844 |
|
NCBI chr 9:94,282,417...94,314,109
Ensembl chr 9:94,282,509...94,314,103
|
|
G
|
Atg5
|
autophagy related 5
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multiple interactions decreases expression increases expression
|
ISO EXP
|
3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of ATG5 protein]; ATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein] 3-methyladenine results in decreased expression of ATG5 protein 3-methyladenine results in increased expression of ATG5 protein 3-methyladenine affects the reaction [Dibutyl Phthalate results in increased expression of ATG5 protein]; 3-methyladenine affects the reaction [T-2 Toxin affects the expression of ATG5 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG5 mRNA] 3-methyladenine results in decreased expression of ATG5 mRNA; 3-methyladenine results in decreased expression of ATG5 protein 3-methyladenine inhibits the reaction [aristolochic acid I results in increased expression of ATG5 protein]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of ATG5 protein]]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of ATG5 protein]; 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of ATG5 protein]
|
CTD |
PMID:18818525 PMID:23939141 PMID:28184909 PMID:29128638 PMID:29781141 PMID:30611790 PMID:32587277 PMID:33462182 PMID:36402210 PMID:37169277 PMID:37277016 PMID:37329965 PMID:37654027 More...
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|
NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
|
|
G
|
Atg7
|
autophagy related 7
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA]; 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of ATG7 protein]; 3-methyladenine inhibits the reaction [beta-lapachone results in increased expression of ATG7 protein]; 3-methyladenine inhibits the reaction [rottlerin results in increased expression of ATG7 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased expression of ATG7 mRNA] 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of ATG7 mRNA]
|
CTD |
PMID:22902833 PMID:29078374 PMID:33462182 PMID:37329965 PMID:38218311 |
|
NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593
|
|
G
|
Atp5pd
|
ATP synthase peripheral stalk subunit d
|
multiple interactions
|
ISO
|
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of ATP5PD mRNA]
|
CTD |
PMID:29078374 |
|
NCBI chr10:101,156,673...101,161,926
Ensembl chr10:100,657,708...100,663,479
|
|
G
|
Bax
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BCL2 associated X, apoptosis regulator
|
multiple interactions
|
EXP ISO
|
3-methyladenine inhibits the reaction [citreoviridin results in increased expression of BAX protein]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in increased expression of BAX protein]]; 3-methyladenine promotes the reaction [4-nonylphenol results in increased expression of BAX protein] 3-methyladenine affects the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of BAX protein]]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in increased expression of BAX protein]; 3-methyladenine inhibits the reaction [nuciferine results in decreased expression of BAX protein] 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]; 3-methyladenine inhibits the reaction [Nicotine results in increased expression of BAX protein]
|
CTD |
PMID:26804764 PMID:31419397 PMID:32043704 PMID:33010382 PMID:36502962 PMID:37126988 PMID:37769856 PMID:38065397 More...
|
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
ISO EXP
|
3-methyladenine inhibits the reaction [alisol A 24-acetate results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [alisol B 23-acetate results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2]; 3-methyladenine inhibits the reaction [Artesunate results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [Nicotine results in decreased expression of BCL2 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of BCL2 protein]; [3-methyladenine co-treated with Amiodarone] results in decreased expression of BCL2 protein 3-methyladenine inhibits the reaction [Alpha-Amanitin results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in decreased expression of BCL2 protein]; 3-methyladenine inhibits the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of BCL2 protein]]; 3-methyladenine inhibits the reaction [nuciferine results in increased expression of BCL2 protein] 3-methyladenine inhibits the reaction [citreoviridin results in decreased expression of BCL2 protein]
|
CTD |
PMID:23912912 PMID:25110043 PMID:28408883 PMID:31419397 PMID:33002460 PMID:33010382 PMID:34053323 PMID:35175747 PMID:36502962 PMID:36843289 PMID:37126988 PMID:38065397 More...
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|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions increases expression
|
ISO
|
3-methyladenine inhibits the reaction [Fluorouracil results in increased expression of BCL2L1 protein] 3-methyladenine results in increased expression of BCL2L1 mRNA
|
CTD |
PMID:19116755 PMID:21681844 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G
|
Becn1
|
beclin 1
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multiple interactions decreases expression affects response to substance
|
ISO EXP
|
3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1]; 3-methyladenine inhibits the reaction [BECN1 protein results in decreased susceptibility to Staurosporine]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [E platinum results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in decreased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [rottlerin results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; 3-methyladenine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased expression of BECN1 protein]; Ropivacaine inhibits the reaction [3-methyladenine results in decreased expression of BECN1 protein] 3-methyladenine affects the reaction [Dibutyl Phthalate results in increased expression of BECN1 protein]; 3-methyladenine affects the reaction [T-2 Toxin affects the expression of BECN1 protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of BECN1 mRNA]; 3-methyladenine inhibits the reaction [Busulfan results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Caffeine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [jujuboside A promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [nuciferine results in increased expression of BECN1 protein] 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [4-nonylphenol results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Acrylamide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [glycidamide results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in decreased expression of BECN1 protein]]; 3-methyladenine inhibits the reaction [T-2 Toxin results in increased expression of BECN1 mRNA] BECN1 protein affects the susceptibility to 3-methyladenine 3-methyladenine results in decreased expression of BECN1 mRNA; 3-methyladenine results in decreased expression of BECN1 protein
|
CTD |
PMID:16497721 PMID:18619688 PMID:20525898 PMID:22322152 PMID:22902833 PMID:25110043 PMID:25622137 PMID:26804764 PMID:28025121 PMID:28130038 PMID:28184909 PMID:29518472 PMID:29923297 PMID:30365942 PMID:30555576 PMID:30611790 PMID:30629952 PMID:31421117 PMID:32043704 PMID:32061152 PMID:32687844 PMID:33462182 PMID:33545342 PMID:34051206 PMID:34423507 PMID:35066094 PMID:36193553 PMID:36402210 PMID:36502962 PMID:37126988 PMID:37277016 PMID:37329965 PMID:37769856 PMID:38065397 PMID:38220133 More...
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|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
|
|
G
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Bid
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BH3 interacting domain death agonist
|
increases cleavage
|
ISO
|
3-methyladenine results in increased cleavage of BID protein
|
CTD |
PMID:26853465 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720
|
|
G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [sepantronium results in decreased expression of BIRC5 protein]
|
CTD |
PMID:31837377 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
|
|
G
|
Bmp2
|
bone morphogenetic protein 2
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Benzo(a)pyrene results in decreased expression of BMP2 mRNA]; 3-methyladenine inhibits the reaction [Benzo(a)pyrene results in decreased expression of BMP2 protein]
|
CTD |
PMID:39454710 |
|
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
|
|
G
|
Bnip3
|
BCL2 interacting protein 3
|
decreases expression
|
ISO
|
3-methyladenine results in decreased expression of BNIP3 protein
|
CTD |
PMID:26853465 |
|
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
|
|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
ISO EXP
|
3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased cleavage of CASP1 protein]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of CASP1 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased cleavage of CASP1 protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of CASP1 protein] 3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the cleavage of CASP1 protein] 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of CASP1 protein modified form]; 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased cleavage of CASP1 protein]
|
CTD |
PMID:27611972 PMID:30205151 PMID:30237538 PMID:31586597 PMID:33217525 PMID:34238121 PMID:37654027 More...
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|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases cleavage increases activity increases expression
|
ISO EXP
|
3-methyladenine inhibits the reaction [Alpha-Amanitin results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased cleavage of CASP3 protein]]; 3-methyladenine inhibits the reaction [procyanidin B2 inhibits the reaction [Hydrogen Peroxide results in increased expression of CASP3 mRNA]]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein] 3-methyladenine results in increased cleavage of CASP3 protein 3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP3 protein]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in increased expression of CASP3 protein]]; 3-methyladenine inhibits the reaction [Oxidopamine results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [sodium arsenite results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [4-nonylphenol results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [T-2 Toxin results in increased expression of CASP3 protein modified form] 3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]; 3-methyladenine inhibits the reaction [perfluorooctane sulfonic acid results in increased activity of CASP3 protein]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of CASP3 protein modified form]; 3-methyladenine inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [astin B results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [dihydrocapsaicin results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP3 protein]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [Paraquat results in increased activity of CASP3 protein]; 3-methyladenine promotes the reaction [Potassium Dichromate results in increased expression of CASP3 protein modified form]; 3-methyladenine promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of and results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [tetrandrine results in increased cleavage of CASP3 protein]; 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; 3-methyladenine results in increased expression of and results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [3-methyladenine co-treated with fosbretabulin] results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with Miconazole] results in increased cleavage of CASP3 protein; [3-methyladenine co-treated with vandetanib] results in increased activity of CASP3 protein; ATG5 protein affects the reaction [3-methyladenine results in increased activity of CASP3 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP3 protein]]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [3-methyladenine promotes the reaction [dihydrocapsaicin results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartic acid inhibits the reaction [dihydrocapsaicin promotes the reaction [3-methyladenine results in increased activity of CASP3 protein]]; benzyloxycarbonyl-valyl-alanyl-aspartyl-fluoromethane inhibits the reaction [3-methyladenine results in increased activity of CASP3 protein]; dihydrocapsaicin promotes the reaction [3-methyladenine results in increased activity of CASP3 protein] 3-methyladenine results in increased expression of CASP3 mRNA
|
CTD |
PMID:16497721 PMID:17341480 PMID:18818525 PMID:19116755 PMID:19139269 PMID:20104024 PMID:20426806 PMID:20929985 PMID:21681844 PMID:23380477 PMID:23799852 PMID:23912912 PMID:24321340 PMID:25078063 PMID:25219577 PMID:25266202 PMID:25639566 PMID:25939952 PMID:26804764 PMID:26822499 PMID:26853465 PMID:27057282 PMID:27413105 PMID:28219700 PMID:28483490 PMID:28722333 PMID:28802652 PMID:29902662 PMID:30465897 PMID:30629952 PMID:31226464 PMID:31421117 PMID:32043704 PMID:32569804 PMID:32981224 PMID:33002460 PMID:34053323 PMID:34374793 PMID:35175747 PMID:36502962 PMID:37741534 PMID:37769856 More...
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|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G
|
Casp4
|
caspase 4
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increases activity
|
ISO
|
3-methyladenine results in increased activity of CASP4 protein
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CTD |
PMID:20371669 |
|
NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G
|
Casp7
|
caspase 7
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increases activity multiple interactions
|
ISO
|
3-methyladenine results in increased activity of CASP7 protein 3-methyladenine promotes the reaction [usnic acid results in increased activity of CASP7 protein]
|
CTD |
PMID:20371669 PMID:25078063 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G
|
Casp8
|
caspase 8
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multiple interactions
|
ISO
|
3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP8 protein]]]
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CTD |
PMID:20104024 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G
|
Casp9
|
caspase 9
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multiple interactions
|
ISO EXP
|
3-methyladenine inhibits the reaction [Acrolein results in increased cleavage of CASP9 protein]; 3-methyladenine inhibits the reaction [Cannabidiol results in increased activity of CASP9 protein]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased activity of CASP9 protein]]; 3-methyladenine inhibits the reaction [Diosgenin inhibits the reaction [alpha-Chlorohydrin results in increased cleavage of CASP9 protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CASP9 protein modified form]; 3-methyladenine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; 3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [BO-1012 results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]; 3-methyladenine promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; 3-methyladenine promotes the reaction [embelin results in increased degradation of CASP9 protein]; [3-methyladenine co-treated with Potassium Dichromate] results in increased expression of CASP9 protein modified form; [3-methyladenine co-treated with vandetanib] results in increased activity of CASP9 protein; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [ABT-737 promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]]; benzyloxycarbonyl-isoleucyl-glutamyl-threonyl-aspartic acid fluoromethyl ketone inhibits the reaction [3-methyladenine promotes the reaction [Celecoxib promotes the reaction [ABT-737 results in increased cleavage of CASP9 protein]]] 3-methyladenine inhibits the reaction [Aminolevulinic Acid analog results in increased activity of CASP9 protein]; 3-methyladenine promotes the reaction [Staurosporine results in increased cleavage of CASP9 protein]
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CTD |
PMID:16497721 PMID:20104024 PMID:20426806 PMID:23799852 PMID:24823293 PMID:28184909 PMID:28722333 PMID:29902662 PMID:31226464 PMID:32569804 PMID:34302491 PMID:35149085 More...
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Ensembl chr 5:154,109,046...154,126,626
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G
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Cat
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catalase
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in decreased activity of CAT protein]]
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CTD |
PMID:34051206 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G
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Ccn1
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cellular communication network factor 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]
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CTD |
PMID:34405320 |
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NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G
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Ccnd1
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cyclin D1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [[Lactic Acid co-treated with [Cadmium Chloride results in increased abundance of Cadmium]] results in increased expression of CCND1 protein]
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CTD |
PMID:36336208 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G
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Ccne1
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cyclin E1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of CCNE1 protein]]
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CTD |
PMID:36336208 |
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NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G
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Cdh1
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cadherin 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [epigallocatechin gallate results in increased expression of CDH1 protein]
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CTD |
PMID:39313106 |
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NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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G
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Cdh2
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cadherin 2
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [epigallocatechin gallate results in decreased expression of CDH2 protein]
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CTD |
PMID:39313106 |
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NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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G
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Cdh5
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cadherin 5
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [nuciferine results in increased expression of CDH5 protein]
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CTD |
PMID:37126988 |
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NCBI chr19:821,875...860,931
Ensembl chr19:815,411...854,368
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G
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Cdkn1a
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cyclin-dependent kinase inhibitor 1A
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased expression of CDKN1A protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein]
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CTD |
PMID:22927544 PMID:30555576 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G
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Cdx2
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caudal type homeo box 2
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increases expression
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ISO
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3-methyladenine results in increased expression of CDX2 mRNA
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CTD |
PMID:21681844 |
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NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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G
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Cebpa
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CCAAT/enhancer binding protein alpha
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multiple interactions
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ISO
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[Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of CEBPA mRNA]
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CTD |
PMID:29078374 |
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NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
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G
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Chek1
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checkpoint kinase 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [BO-1012 results in increased phosphorylation of CHEK1 protein]
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CTD |
PMID:24823293 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G
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Ckb
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creatine kinase B
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]
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CTD |
PMID:31419397 |
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NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315
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G
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Ckm
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creatine kinase, M-type
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of [CKM protein binds to CKB protein]]
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CTD |
PMID:31419397 |
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NCBI chr 1:88,189,382...88,199,717
Ensembl chr 1:79,061,456...79,071,720
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G
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Col1a1
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collagen type I alpha 1 chain
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multiple interactions
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EXP ISO
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3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of COL1A1 mRNA]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of COL1A1 protein] 3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of COL1A1 protein]
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CTD |
PMID:35066094 PMID:37169277 PMID:38477077 |
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NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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G
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Col1a2
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collagen type I alpha 2 chain
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multiple interactions
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ISO
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3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of COL1A2 protein]
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CTD |
PMID:36402210 |
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NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
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G
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Col2a1
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collagen type II alpha 1 chain
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]]
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CTD |
PMID:34122080 |
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NCBI chr 7:129,098,489...129,127,560
Ensembl chr 7:129,098,786...129,127,546
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G
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Ctnnb1
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catenin beta 1
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multiple interactions
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ISO
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3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of CTNNB1 protein]
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CTD |
PMID:36402210 |
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G
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Ctsb
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cathepsin B
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of CTSB protein]; 3-methyladenine inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; 3-methyladenine inhibits the reaction [Acrolein results in increased expression of CTSB protein]; 3-methyladenine inhibits the reaction [Patulin results in increased secretion of CTSB protein] 3-methyladenine inhibits the reaction [nuciferine results in increased expression of CTSB protein]
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CTD |
PMID:23380477 PMID:29902662 PMID:30237538 PMID:33217525 PMID:37126988 |
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NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
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G
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Ctsd
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cathepsin D
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [nuciferine results in increased expression of CTSD protein]
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CTD |
PMID:37126988 |
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NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
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G
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Ctsl
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cathepsin L
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Cadmium Chloride results in increased cleavage of CTSL protein]
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CTD |
PMID:25639782 |
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NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
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G
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Cxcl2
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C-X-C motif chemokine ligand 2
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL2 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL2 protein]
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CTD |
PMID:28867211 |
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NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
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G
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Cxcl3
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C-X-C motif chemokine ligand 3
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL1 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of CXCL1 protein]
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CTD |
PMID:28867211 |
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NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
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G
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Cybb
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cytochrome b-245 beta chain
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of CYBB protein]]
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CTD |
PMID:36502962 |
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NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586
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G
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Cycs
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cytochrome c, somatic
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multiple interactions
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ISO
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3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein]
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CTD |
PMID:20929985 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G
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Ddit3
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DNA-damage inducible transcript 3
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multiple interactions
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ISO EXP
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3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of DDIT3 protein]
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CTD |
PMID:28245985 PMID:37654027 |
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NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G
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Eif2ak3
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eukaryotic translation initiation factor 2 alpha kinase 3
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multiple interactions
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ISO EXP
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[3-methyladenine co-treated with Potassium Dichromate] results in increased expression of EIF2AK3 protein modified form 3-methyladenine promotes the reaction [Lipopolysaccharides results in increased phosphorylation of EIF2AK3 protein]
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CTD |
PMID:32569804 PMID:37654027 |
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NCBI chr 4:104,363,838...104,425,271
Ensembl chr 4:102,805,510...102,866,911
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G
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Eif4ebp1
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eukaryotic translation initiation factor 4E binding protein 1
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decreases phosphorylation multiple interactions
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EXP ISO
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3-methyladenine results in decreased phosphorylation of EIF4EBP1 protein 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of EIF4EBP1 protein]]
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CTD |
PMID:26804764 PMID:35149085 |
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NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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G
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Elavl1
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ELAV like RNA binding protein 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [sepantronium results in decreased expression of and results in decreased stability of ELAVL1 mRNA]; 3-methyladenine inhibits the reaction [sepantronium results in decreased expression of ELAVL1 protein]
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CTD |
PMID:31837377 |
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NCBI chr12:2,640,936...2,684,787
Ensembl chr12:2,645,061...2,684,784
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G
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Eno2
|
enolase 2
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein]
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CTD |
PMID:26676567 |
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NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980
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G
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Flt1
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Fms related receptor tyrosine kinase 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [nuciferine results in increased expression of FLT1 protein]
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CTD |
PMID:37126988 |
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NCBI chr12:12,333,050...12,504,750
Ensembl chr12:7,297,292...7,468,626
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G
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Fn1
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fibronectin 1
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of FN1 protein]; 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased phosphorylation of and results in increased lipidation of FN1 protein]
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CTD |
PMID:37169277 |
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NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G
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Fth1
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ferritin heavy chain 1
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multiple interactions
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ISO EXP
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3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in decreased expression of FTH1 protein] 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of FTH1 protein] 3-methyladenine promotes the reaction [erastin results in increased expression of FTH1 protein]
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CTD |
PMID:32687844 PMID:32937103 PMID:38220133 |
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NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
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G
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Gabarap
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GABA type A receptor-associated protein
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decreases expression
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ISO
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3-methyladenine results in decreased expression of GABARAP mRNA
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CTD |
PMID:21681844 |
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NCBI chr10:55,213,465...55,216,787
Ensembl chr10:54,714,198...54,717,765
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G
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Gap43
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growth associated protein 43
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [sodium arsenite results in decreased expression of GAP43]
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CTD |
PMID:25639566 |
|
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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G
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Gja1
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gap junction protein, alpha 1
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in decreased expression of GJA1 protein]
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CTD |
PMID:33242459 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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G
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Got1
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glutamic-oxaloacetic transaminase 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Ethanol results in increased secretion of GOT1 protein]
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CTD |
PMID:37898230 |
|
NCBI chr 1:252,306,541...252,337,622
Ensembl chr 1:242,357,306...242,380,633
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G
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Gpt
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glutamic--pyruvic transaminase
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increases expression multiple interactions
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ISO
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3-methyladenine results in increased expression of GPT protein 3-methyladenine inhibits the reaction [Ethanol results in increased secretion of GPT protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein]
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CTD |
PMID:31513885 PMID:37898230 |
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NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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G
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Gpx4
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glutathione peroxidase 4
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Busulfan results in decreased expression of GPX4 protein] 3-methyladenine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GPX4 protein]
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CTD |
PMID:38220133 PMID:39033796 |
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NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G
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Gsdmd
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gasdermin D
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multiple interactions
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EXP
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3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of GSDMD protein]
|
CTD |
PMID:37654027 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G
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Gsk3b
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glycogen synthase kinase 3 beta
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of GSK3B protein] 3-methyladenine promotes the reaction [T-2 Toxin results in increased expression of GSK3B protein]
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CTD |
PMID:30362509 PMID:36402210 |
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NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G
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Gys1
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glycogen synthase 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of GYS1 protein]
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CTD |
PMID:30362509 |
|
NCBI chr 1:105,051,916...105,071,763
Ensembl chr 1:95,915,443...95,935,292
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G
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H2ax
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H2A.X variant histone
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Aflatoxin B1 results in increased expression of H2AX protein]
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CTD |
PMID:34396909 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G
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Havcr1
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hepatitis A virus cellular receptor 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [alisol A 24-acetate results in increased expression of HAVCR1 protein]; 3-methyladenine inhibits the reaction [alisol B 23-acetate results in increased expression of HAVCR1 protein]
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CTD |
PMID:28408883 |
|
NCBI chr10:31,619,914...31,652,955
Ensembl chr10:31,119,088...31,151,698
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G
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Hes1
|
hes family bHLH transcription factor 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HES1 mRNA]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HES1 protein]
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CTD |
PMID:37277016 |
|
NCBI chr11:84,210,632...84,213,045
Ensembl chr11:70,705,764...70,708,192
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G
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Hey2
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hes-related family bHLH transcription factor with YRPW motif 2
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HEY2 mRNA]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of HEY2 protein]
|
CTD |
PMID:37277016 |
|
NCBI chr 1:28,641,100...28,651,187
Ensembl chr 1:26,822,131...26,832,218
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G
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Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]
|
CTD |
PMID:18927491 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G
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Hk2
|
hexokinase 2
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multiple interactions decreases expression
|
ISO
|
3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of HK2 protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of HK2 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of HK2 protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of HK2 protein]
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CTD |
PMID:32569804 PMID:34053323 PMID:34481905 PMID:36336208 |
|
NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530
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G
|
Hmga2
|
high mobility group AT-hook 2
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [HMGA2 protein results in decreased expression of COX4 protein]; 3-methyladenine inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]
|
CTD |
PMID:34481905 |
|
NCBI chr 7:57,762,710...57,884,555
Ensembl chr 7:55,880,112...55,994,784
|
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G
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Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [nuciferine results in increased expression of HMOX1 protein]
|
CTD |
PMID:37126988 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
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G
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Hoxa10
|
homeobox A10
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HOXA10 mRNA]; 3-methyladenine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HOXA10 protein]
|
CTD |
PMID:39454710 |
|
NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
multiple interactions
|
ISO
|
3-methyladenine promotes the reaction [Lipopolysaccharides results in increased expression of HSPA5 protein]; 3-methyladenine promotes the reaction [Potassium Dichromate results in increased expression of HSPA5 protein]
|
CTD |
PMID:28245985 PMID:32569804 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G
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Icam1
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intercellular adhesion molecule 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
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CTD |
PMID:24145604 |
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NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G
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Il18
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interleukin 18
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multiple interactions
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ISO EXP
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3-methyladenine inhibits the reaction [Patulin results in increased expression of IL18 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL18 protein] 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of IL18 protein]
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CTD |
PMID:30205151 PMID:33217525 PMID:37169277 |
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NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
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G
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Il1b
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interleukin 1 beta
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multiple interactions increases expression
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ISO EXP
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3-methyladenine inhibits the reaction [[Arsenic Trioxide co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in increased expression of IL1B protein]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of IL1B protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of IL1B protein] 3-methyladenine results in increased expression of IL1B mRNA 3-methyladenine affects the reaction [[HU 308 co-treated with Dextran Sulfate] affects the expression of IL1B protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B protein]]; 3-methyladenine inhibits the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of and results in increased cleavage of IL1B protein]]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL1B mRNA] 3-methyladenine inhibits the reaction [lead acetate results in increased expression of IL1B protein]; 3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in decreased expression of COL2A1 protein]]; 3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of ADAMTS5 protein]]; 3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]]; 3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]]; 3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]; 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of IL1B protein modified form]
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CTD |
PMID:27611972 PMID:30205151 PMID:30237538 PMID:31513885 PMID:31586597 PMID:32879255 PMID:33217525 PMID:34051206 PMID:34122080 PMID:34238121 PMID:36502962 More...
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G
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Il6
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interleukin 6
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multiple interactions increases expression
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ISO
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3-methyladenine inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein]]; 3-methyladenine inhibits the reaction [nuciferine results in decreased expression of IL6 protein]; [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in increased secretion of IL6 protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA] 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 mRNA]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of IL6 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]
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CTD |
PMID:28867211 PMID:29078374 PMID:29781141 PMID:31513885 PMID:34051206 PMID:37126988 More...
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G
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Irs1
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insulin receptor substrate 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased phosphorylation of IRS1 protein]
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CTD |
PMID:30362509 |
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NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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G
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Itgam
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integrin subunit alpha M
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased expression of ITGAM protein]; 3-methyladenine inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; 3-methyladenine inhibits the reaction [Tretinoin results in increased localization of and results in increased expression of ITGAM protein]; [benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with 3-methyladenine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]
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CTD |
PMID:20574048 PMID:28130038 PMID:29743969 |
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NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
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G
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Jag1
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jagged canonical Notch ligand 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of JAG1 mRNA]
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CTD |
PMID:37277016 |
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NCBI chr 3:144,859,453...144,894,883
Ensembl chr 3:124,406,794...124,442,209
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G
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Jag2
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jagged canonical Notch ligand 2
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of JAG2 mRNA]
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CTD |
PMID:37277016 |
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NCBI chr 6:137,804,133...137,826,738
Ensembl chr 6:131,983,056...132,005,818
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G
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Jak2
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Janus kinase 2
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decreases phosphorylation
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ISO
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3-methyladenine co-treated with anlotinib decreases phosphorylation of JAK2 protein in lung epithelium
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RGD |
PMID:30755242 |
RGD:149735343 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G
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Keap1
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Kelch-like ECH-associated protein 1
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decreases expression
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ISO
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3-methyladenine results in decreased expression of KEAP1 protein
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CTD |
PMID:29781141 |
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NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
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G
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Lamp1
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lysosomal-associated membrane protein 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of LAMP1 protein] 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of LAMP1 mRNA]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of LAMP1 protein]
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CTD |
PMID:31226464 PMID:33462182 |
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NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883
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G
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Lamp2
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lysosomal-associated membrane protein 2
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of LAMP2 protein] 3-methyladenine inhibits the reaction [nuciferine results in increased expression of LAMP2 protein]
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CTD |
PMID:31226464 PMID:37126988 |
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NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522
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G
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Ldha
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lactate dehydrogenase A
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multiple interactions decreases expression
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ISO
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3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of LDHA protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of LDHA protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of LDHA protein] 3-methyladenine inhibits the reaction [Ethanol results in increased secretion of LDHA protein]
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CTD |
PMID:32569804 PMID:34481905 PMID:36336208 PMID:37898230 |
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NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
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G
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Lgals1
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galectin 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [LGALS1 protein results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased susceptibility to Cisplatin]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of BECN1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of MAP1LC3B protein modified form]
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CTD |
PMID:30365942 |
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NCBI chr 7:112,365,695...112,368,801
Ensembl chr 7:110,481,392...110,488,345
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G
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Lrrk2
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leucine-rich repeat kinase 2
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [LRRK2 gene mutant form results in increased susceptibility to 1-Methyl-4-phenylpyridinium]
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CTD |
PMID:25017139 |
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NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703
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G
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Map1lc3a
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microtubule-associated protein 1 light chain 3 alpha
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multiple interactions affects metabolic processing
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ISO
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3-methyladenine inhibits the reaction [isobavachin results in increased lipidation of and results in increased localization of MAP1LC3A protein]; 3-methyladenine inhibits the reaction [sodium arsenite results in increased expression of MAP1LC3A protein modified form] 3-methyladenine inhibits the reaction [alisol A 24-acetate results in increased expression of MAP1LC3A protein]; 3-methyladenine inhibits the reaction [alisol B 23-acetate results in increased expression of MAP1LC3A protein] 3-methyladenine affects the metabolism of MAP1LC3A protein
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CTD |
PMID:20008137 PMID:21742779 PMID:28408883 PMID:39154867 |
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NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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G
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Map1lc3b
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microtubule-associated protein 1 light chain 3 beta
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multiple interactions increases expression increases lipidation decreases expression decreases cleavage affects metabolic processing
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ISO EXP
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3-methyladenine affects the reaction [Alpha-Amanitin affects the lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [ABBV-744 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [beta-ionone results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [bisphenol A results in increased lipidation of and results in increased localization of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [bisphenol A results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [dimethyl alpha-ketoglutarate results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [E platinum results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [E platinum results in increased metabolism of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAP1LC3B mRNA]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Ivermectin results in increased expression of and results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Quercetin results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [sepantronium results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine results in increased expression of and results in increased lipidation of MAP1LC3B protein; [3-methyladenine co-treated with TNF protein] results in decreased expression of MAP1LC3B protein alternative form; [bisphenol A co-treated with 3-methyladenine] results in increased lipidation of MAP1LC3B protein; Cadmium Chloride promotes the reaction [3-methyladenine results in increased expression of MAP1LC3B protein modified form] 3-methyladenine results in increased lipidation of MAP1LC3B protein 3-methyladenine results in decreased expression of MAP1LC3B mRNA 3-methyladenine results in decreased cleavage of MAP1LC3B protein 3-methyladenine affects the metabolism of MAP1LC3B protein 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in decreased expression of MAP1LC3B protein]]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in decreased lipidation of MAP1LC3B protein]]; 3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP1LC3B protein modified form]; 3-methyladenine results in decreased expression of and results in decreased cleavage of MAP1LC3B protein 3-methyladenine results in decreased expression of MAP1LC3B mRNA; 3-methyladenine results in decreased expression of MAP1LC3B protein modified form 3-methyladenine affects the reaction [T-2 Toxin affects the expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Busulfan results in increased expression of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Caffeine results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [dibromoacetonitrile results in increased expression of and results in increased localization of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Dibutyl Phthalate results in increased cleavage of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [Ethanol results in increased lipidation of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [isobavachin results in increased lipidation of and results in increased localization of MAP1LC3B protein]; 3-methyladenine inhibits the reaction [jujuboside A promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased lipidation of MAP1LC3B protein]]; 3-methyladenine inhibits the reaction [nuciferine results in increased expression of MAP1LC3B protein]; cupric chloride inhibits the reaction [3-methyladenine results in decreased expression of MAP1LC3B protein modified form]
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CTD |
PMID:18640276 PMID:20962572 PMID:21325019 PMID:21681844 PMID:22322152 PMID:23680031 PMID:24145604 PMID:25639782 PMID:26804720 PMID:28251795 PMID:28867211 PMID:29128638 PMID:29518472 PMID:30025493 PMID:30365942 PMID:30555576 PMID:30611790 PMID:30677399 PMID:31837377 PMID:32043704 PMID:32512069 PMID:32687844 PMID:32937103 PMID:33002460 PMID:34281243 PMID:34580807 PMID:34634291 PMID:34904774 PMID:35149085 PMID:35472370 PMID:36111830 PMID:36402210 PMID:36502962 PMID:36708882 PMID:36843289 PMID:37126988 PMID:37329965 PMID:37741534 PMID:37769529 PMID:37769856 PMID:38000454 PMID:38065397 PMID:38103660 PMID:38220133 PMID:38326183 PMID:39154867 More...
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NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G
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Map2
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microtubule-associated protein 2
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein]
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CTD |
PMID:26676567 |
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NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809
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G
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Map3k5
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mitogen-activated protein kinase kinase kinase 5
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affects response to substance multiple interactions
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ISO
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3-methyladenine affects the susceptibility to MAP3K5 protein 3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]; 3-methyladenine promotes the reaction [MAP3K5 protein affects the localization of CYCS protein]; 3-methyladenine promotes the reaction [MAP3K5 protein results in increased activity of CASP3 protein]
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CTD |
PMID:20929985 |
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NCBI chr 1:16,505,387...16,723,899
Ensembl chr 1:14,685,492...14,904,800
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G
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Mapk1
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mitogen activated protein kinase 1
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increases expression increases phosphorylation multiple interactions
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ISO
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3-methyladenine results in increased expression of MAPK1 protein modified form 3-methyladenine results in increased phosphorylation of MAPK1 protein 3-methyladenine inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]; Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [3-methyladenine results in increased phosphorylation of MAPK1 protein]; U 0126 inhibits the reaction [Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK1 protein]]
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CTD |
PMID:28483490 PMID:34580807 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G
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Mapk3
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mitogen activated protein kinase 3
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increases expression increases phosphorylation multiple interactions
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ISO
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3-methyladenine results in increased expression of MAPK3 protein modified form 3-methyladenine results in increased phosphorylation of MAPK3 protein 3-methyladenine inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]; U 0126 inhibits the reaction [Cadmium Chloride promotes the reaction [3-methyladenine results in increased phosphorylation of MAPK3 protein]]
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CTD |
PMID:28483490 PMID:34580807 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
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Mcl1
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MCL1 apoptosis regulator, BCL2 family member
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [sepantronium results in decreased expression of MCL1 protein]; 3-methyladenine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]
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CTD |
PMID:25078063 PMID:31837377 |
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NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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G
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Mlkl
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mixed lineage kinase domain like pseudokinase
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Ethanol results in increased expression of and results in increased phosphorylation of MLKL protein]
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CTD |
PMID:37898230 |
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NCBI chr19:39,277,526...39,304,555
Ensembl chr19:39,276,785...39,304,502
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G
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Mmp13
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matrix metallopeptidase 13
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of MMP13 protein]]
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CTD |
PMID:34122080 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G
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Mmp2
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matrix metallopeptidase 2
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP2 protein]]
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CTD |
PMID:36336208 |
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NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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G
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Mmp9
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matrix metallopeptidase 9
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased expression of MMP9 protein]; 3-methyladenine inhibits the reaction [Lactic Acid promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MMP9 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]
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CTD |
PMID:24145604 PMID:32043704 PMID:36336208 |
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NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G
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Mpg
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N-methylpurine-DNA glycosylase
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increases metabolic processing
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ISO
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MPG protein results in increased metabolism of 3-methyladenine
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CTD |
PMID:10626224 |
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NCBI chr10:15,396,246...15,402,528
Ensembl chr10:15,395,782...15,402,520
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G
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Mpo
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myeloperoxidase
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [lead acetate results in increased expression of MPO protein]
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CTD |
PMID:32879255 |
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NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G
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Mt-co2
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mitochondrially encoded cytochrome c oxidase II
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Curcumin results in decreased expression of COX2 protein]
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CTD |
PMID:37634662 |
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NCBI chr MT:7,006...7,689
Ensembl chr MT:7,006...7,689
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G
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Mt-nd1
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mitochondrially encoded NADH:ubiquinone oxidoreductase core subunit 1
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [HMGA2 protein results in decreased expression of ND1 protein]
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CTD |
PMID:34481905 |
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NCBI chr MT:2,740...3,694
Ensembl chr MT:2,740...3,694
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G
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Mtor
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mechanistic target of rapamycin kinase
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multiple interactions decreases expression increases phosphorylation increases expression decreases phosphorylation
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ISO EXP
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3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of MTOR protein]; 3-methyladenine inhibits the reaction [Cisplatin results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [dimethyl alpha-ketoglutarate results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [Diosgenin promotes the reaction [alpha-Chlorohydrin results in decreased phosphorylation of MTOR protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [MAP3K5 protein results in decreased phosphorylation of MTOR protein]; 3-methyladenine results in decreased expression of and results in decreased phosphorylation of MTOR protein; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of MTOR protein] 3-methyladenine results in increased phosphorylation of MTOR protein 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased phosphorylation of MTOR protein]; 3-methyladenine inhibits the reaction [isobavachin results in decreased phosphorylation of MTOR protein] 3-methyladenine results in increased expression of MTOR protein 3-methyladenine results in decreased phosphorylation of MTOR protein
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CTD |
PMID:20929985 PMID:26804764 PMID:29518472 PMID:32043704 PMID:33462182 PMID:35149085 PMID:36111830 PMID:36336208 PMID:37329965 PMID:37700640 PMID:39154867 More...
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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G
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Nanog
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Nanog homeobox
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increases expression
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ISO
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3-methyladenine results in increased expression of NANOG mRNA
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CTD |
PMID:21681844 |
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NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116
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G
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Ncoa4
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nuclear receptor coactivator 4
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multiple interactions
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ISO EXP
|
3-methyladenine inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of NCOA4 protein] 3-methyladenine inhibits the reaction [Busulfan results in increased expression of NCOA4 protein] 3-methyladenine inhibits the reaction [erastin results in decreased expression of NCOA4 protein]
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CTD |
PMID:32687844 PMID:32937103 PMID:38220133 |
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NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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G
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Ndufa1
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NADH:ubiquinone oxidoreductase subunit A1
|
multiple interactions
|
ISO
|
[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA] [Taurine co-treated with 3-methyladenine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA1 mRNA]
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CTD |
PMID:29078374 |
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NCBI chr X:121,289,904...121,293,555
Ensembl chr X:116,424,223...116,428,633
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G
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Ndufa2
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NADH:ubiquinone oxidoreductase subunit A2
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multiple interactions
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ISO
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[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA] 3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]; Taurine promotes the reaction [3-methyladenine inhibits the reaction [1-nitropyrene results in decreased expression of NDUFA2 mRNA]]
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CTD |
PMID:29078374 |
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NCBI chr18:28,629,795...28,631,884
Ensembl chr18:28,355,774...28,358,076
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G
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Ndufc2
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NADH:ubiquinone oxidoreductase subunit C2
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multiple interactions
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ISO
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[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFC2 mRNA]
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CTD |
PMID:29078374 |
|
NCBI chr 1:161,122,370...161,129,413
Ensembl chr 1:151,711,901...151,718,189
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G
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Ndufs3
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NADH:ubiquinone oxidoreductase core subunit S3
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Chlorpyrifos results in decreased expression of NDUFS3 protein]
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CTD |
PMID:26070385 |
|
NCBI chr 3:97,332,477...97,339,654
Ensembl chr 3:76,876,646...76,883,824
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G
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Ndufs4
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NADH:ubiquinone oxidoreductase subunit S4
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multiple interactions
|
ISO
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[3-methyladenine co-treated with Taurine] inhibits the reaction [1-nitropyrene results in decreased expression of NDUFS4 mRNA]
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CTD |
PMID:29078374 |
|
NCBI chr 2:47,684,420...47,794,914
Ensembl chr 2:45,951,313...46,061,846
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G
|
Nefh
|
neurofilament heavy chain
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFH protein]
|
CTD |
PMID:23743148 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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G
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Nefl
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neurofilament light chain
|
multiple interactions
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ISO
|
3-methyladenine inhibits the reaction [tri-o-cresyl phosphate results in decreased expression of NEFL protein]
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CTD |
PMID:23743148 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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G
|
Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions
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ISO EXP
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3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of NLRP3 protein]]; 3-methyladenine inhibits the reaction [Patulin results in increased expression of NLRP3 protein]; 3-methyladenine promotes the reaction [[Acrolein co-treated with Lipopolysaccharides] results in increased expression of NLRP3 protein]; 3-methyladenine promotes the reaction [Acrolein results in increased expression of NLRP3 protein] 3-methyladenine inhibits the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NLRP3 protein]] 3-methyladenine inhibits the reaction [sphingosine 1-phosphate results in increased expression of NLRP3 protein]
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CTD |
PMID:30205151 PMID:33217525 PMID:34238121 PMID:34423507 PMID:36502962 PMID:37169277 More...
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NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G
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Nos2
|
nitric oxide synthase 2
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multiple interactions
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EXP ISO
|
3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of NOS2 protein]] 3-methyladenine inhibits the reaction [jujuboside A inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of NOS2 protein]]
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CTD |
PMID:34122080 PMID:36502962 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G
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Nos3
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nitric oxide synthase 3
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multiple interactions
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ISO
|
3-methyladenine inhibits the reaction [nuciferine results in increased expression of NOS3 protein]
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CTD |
PMID:37126988 |
|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G
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Notch2
|
notch receptor 2
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Dibutyl Phthalate results in decreased expression of NOTCH2 protein alternative form]
|
CTD |
PMID:37277016 |
|
NCBI chr 2:188,299,336...188,432,823
Ensembl chr 2:185,610,589...185,744,088
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G
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Nppb
|
natriuretic peptide B
|
multiple interactions
|
EXP
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3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of NPPB mRNA]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of NPPB mRNA]
|
CTD |
PMID:35066094 |
|
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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G
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Parp1
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poly (ADP-ribose) polymerase 1
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multiple interactions increases cleavage
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ISO EXP
|
3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein] 3-methyladenine inhibits the reaction [aristolochic acid I results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] 3-methyladenine inhibits the reaction [3,7-dioxolanosta-8,24-dien-26-oic acid results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Artesunate results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [divinyl sulfone analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Fingolimod Hydrochloride results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Morpholines analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [ovatodiolide results in increased cleavage of PARP1 protein]; 3-methyladenine inhibits the reaction [polyphyllin I results in increased expression of PARP1 protein modified form]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [Rotenone results in increased cleavage of PARP1 protein]]; 3-methyladenine promotes the reaction [BO-1012 results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [embelin results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Fluorouracil results in increased cleavage of and results in increased activity of PARP1 protein]; 3-methyladenine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; 3-methyladenine promotes the reaction [Silybin results in increased cleavage of PARP1 protein]; [3-methyladenine co-treated with Amiodarone] results in increased cleavage of PARP1 protein; [3-methyladenine co-treated with fosbretabulin] results in increased cleavage of PARP1 protein; [Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [flavokawain B co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein 3-methyladenine results in increased cleavage of PARP1 protein
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CTD |
PMID:19116755 PMID:21616090 PMID:21778691 PMID:23912912 PMID:23939141 PMID:24321340 PMID:24823293 PMID:24875536 PMID:25939952 PMID:28722333 PMID:30025493 PMID:31421117 PMID:31874162 PMID:33002460 PMID:34053323 PMID:34374793 PMID:36843289 PMID:37741534 PMID:38000454 More...
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G
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Pik3c3
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phosphatidylinositol 3-kinase, catalytic subunit type 3
|
multiple interactions
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ISO EXP
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3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]]; 3-methyladenine inhibits the reaction [gossypetin promotes the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Hydrogen Peroxide promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human promotes the reaction [BECN1 protein binds to PIK3C3 protein]]; 3-methyladenine inhibits the reaction [malondialdehyde-low density lipoprotein, human results in increased expression of PIK3C3 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide promotes the reaction [PIK3C3 protein binds to BECN1 protein]]; [3-methyladenine results in decreased activity of PIK3C3 protein] which results in decreased susceptibility to Hydrogen Peroxide 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of PIK3C3 protein]]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of PIK3C3 protein]
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CTD |
PMID:20525898 PMID:21742779 PMID:25622137 PMID:32061152 PMID:35066094 |
|
NCBI chr18:21,845,282...21,934,387
Ensembl chr18:21,845,295...21,929,048
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G
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Pik3r1
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phosphoinositide-3-kinase regulatory subunit 1
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of PIK3R1 protein]
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CTD |
PMID:32043704 |
|
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
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G
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Pkm
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pyruvate kinase M1/2
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of PKM protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of PKM protein]
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CTD |
PMID:32569804 PMID:34481905 PMID:36336208 |
|
NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
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G
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Pml
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PML nuclear body scaffold
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]
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CTD |
PMID:28130038 |
|
NCBI chr 8:58,627,347...58,661,927
Ensembl chr 8:58,628,837...58,658,971
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G
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Pou5f1
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POU class 5 homeobox 1
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increases expression
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ISO
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3-methyladenine results in increased expression of POU5F1 protein
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CTD |
PMID:21681844 |
|
NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891
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G
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Ppara
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peroxisome proliferator activated receptor alpha
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multiple interactions
|
ISO
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3-methyladenine inhibits the reaction [Arsenic Trioxide results in increased expression of PPARA protein]
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CTD |
PMID:30677399 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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G
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Ppargc1a
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PPARG coactivator 1 alpha
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multiple interactions
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ISO
|
3-methyladenine inhibits the reaction [Nanotubes, Carbon results in decreased expression of PPARGC1A protein]
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CTD |
PMID:39033796 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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G
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Prl
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prolactin
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Benzo(a)pyrene results in decreased expression of PRL mRNA]
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CTD |
PMID:39454710 |
|
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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multiple interactions
|
ISO EXP
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3-methyladenine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]] 3-methyladenine inhibits the reaction [rhoifolin inhibits the reaction [IL1B protein results in increased expression of PTGS2 protein]]
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CTD |
PMID:24145604 PMID:34122080 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G
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Pycard
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PYD and CARD domain containing
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multiple interactions
|
ISO
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3-methyladenine inhibits the reaction [ginsenoside Rg3 inhibits the reaction [Cisplatin results in increased expression of PYCARD protein]]
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CTD |
PMID:34423507 |
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NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955
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G
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Rara
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retinoic acid receptor, alpha
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [4-amino-2-trifluoromethyl-phenyl retinate results in increased degradation of [PML protein mutant form binds to RARA protein mutant form]]
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CTD |
PMID:28130038 |
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NCBI chr10:84,379,780...84,424,371
Ensembl chr10:83,893,384...83,928,142
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions
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ISO EXP
|
3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of RELA protein modified form]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of RELA protein] 3-methyladenine promotes the reaction [Zearalenone results in increased phosphorylation of and affects the localization of RELA protein]
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CTD |
PMID:28867211 PMID:31586597 |
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G
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Ripk1
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receptor interacting serine/threonine kinase 1
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Ethanol results in increased expression of RIPK1 protein]
|
CTD |
PMID:37898230 |
|
NCBI chr17:31,044,983...31,077,167
Ensembl chr17:30,839,650...30,871,824
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G
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Ripk3
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receptor-interacting serine-threonine kinase 3
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multiple interactions
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ISO
|
3-methyladenine inhibits the reaction [Ethanol results in increased expression of RIPK3 protein]
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CTD |
PMID:37898230 |
|
NCBI chr15:33,253,071...33,262,025
Ensembl chr15:29,283,145...29,292,121
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G
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Rps6kb1
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ribosomal protein S6 kinase B1
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decreases phosphorylation increases phosphorylation multiple interactions
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EXP ISO
|
3-methyladenine results in decreased phosphorylation of RPS6KB1 protein 3-methyladenine results in increased phosphorylation of RPS6KB1 protein 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of RPS6KB1 protein]
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CTD |
PMID:26804764 PMID:35149085 |
|
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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G
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Runx2
|
RUNX family transcription factor 2
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multiple interactions
|
ISO
|
3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of RUNX2 protein]
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CTD |
PMID:36402210 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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G
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Slc16a1
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solute carrier family 16 member 1
|
multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC16A1 protein]
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CTD |
PMID:36336208 |
|
NCBI chr 2:194,805,556...194,832,966
Ensembl chr 2:192,124,289...192,144,611
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G
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Slc2a1
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solute carrier family 2 member 1
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multiple interactions decreases expression
|
ISO
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3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of SLC2A1 protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in increased expression of SLC2A1 protein]; 3-methyladenine promotes the reaction [Silybin results in decreased expression of SLC2A1 protein]; 4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine inhibits the reaction [3-methyladenine results in decreased expression of SLC2A1 protein]
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CTD |
PMID:32569804 PMID:34053323 PMID:34481905 PMID:36336208 |
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NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416
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G
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Slc2a4
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solute carrier family 2 member 4
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multiple interactions
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ISO
|
3-methyladenine promotes the reaction [Silybin results in decreased expression of SLC2A4 protein]
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CTD |
PMID:34053323 |
|
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
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G
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Slc7a11
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solute carrier family 7 member 11
|
multiple interactions
|
ISO
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3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SLC7A11 protein] 3-methyladenine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SLC7A11 protein]
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CTD |
PMID:38220133 PMID:39033796 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G
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Snca
|
synuclein alpha
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA mRNA]; 3-methyladenine inhibits the reaction [Rotenone results in decreased expression of SNCA protein]
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CTD |
PMID:27133439 |
|
NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
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G
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Sod1
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superoxide dismutase 1
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multiple interactions
|
ISO
|
3-methyladenine inhibits the reaction [nuciferine results in increased expression of SOD1 protein]
|
CTD |
PMID:37126988 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G
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Sox2
|
SRY-box transcription factor 2
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increases expression
|
ISO
|
3-methyladenine results in increased expression of SOX2 mRNA
|
CTD |
PMID:21681844 |
|
NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338
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G
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Sp7
|
Sp7 transcription factor
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multiple interactions
|
ISO
|
3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of SP7 protein]
|
CTD |
PMID:36402210 |
|
NCBI chr 7:135,363,193...135,373,376
Ensembl chr 7:133,484,609...133,494,847
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G
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Sqstm1
|
sequestosome 1
|
increases expression multiple interactions
|
ISO EXP
|
3-methyladenine results in increased expression of SQSTM1 protein 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Benzo(a)pyrene results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Busulfan results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Ethanol results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [isobavachin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [jujuboside A promotes the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [nuciferine results in decreased expression of SQSTM1 protein] 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Ethanol promotes the reaction [Mirtazapine results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Mirtazapine results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide inhibits the reaction [Glucose results in increased expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [osthol inhibits the reaction [Antineoplastic Agents, Immunological results in increased expression of SQSTM1 protein]] 3-methyladenine affects the reaction [ginsenoside Rg3 affects the reaction [Cisplatin affects the expression of SQSTM1 protein]]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [ABBV-744 results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [bisphenol A results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Ivermectin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [LGALS1 protein results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Potassium Dichromate results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 mRNA]; 3-methyladenine inhibits the reaction [Potassium Iodide results in increased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Quercetin results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; 3-methyladenine inhibits the reaction [sepantronium results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [Silicon Dioxide results in decreased expression of SQSTM1 protein]; 3-methyladenine inhibits the reaction [tris(1,3-dichloro-2-propyl)phosphate results in increased degradation of SQSTM1 protein]; 3-methyladenine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; 3-methyladenine promotes the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; [3-methyladenine co-treated with bisphenol A] results in increased expression of SQSTM1 protein; Ropivacaine inhibits the reaction [3-methyladenine results in increased expression of SQSTM1 protein]
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CTD |
PMID:20574048 PMID:22927544 PMID:24833599 PMID:25943029 PMID:28025121 PMID:28251795 PMID:29128638 PMID:29307831 PMID:29518472 PMID:29781141 PMID:29923297 PMID:30362509 PMID:30365942 PMID:31734597 PMID:31837377 PMID:32061152 PMID:32569804 PMID:32702505 PMID:33462182 PMID:34051206 PMID:34281243 PMID:34405320 PMID:34423507 PMID:34481905 PMID:34580807 PMID:34904774 PMID:35066094 PMID:36193553 PMID:36336208 PMID:36502962 PMID:36708882 PMID:37126988 PMID:37700640 PMID:37769529 PMID:37769856 PMID:38000454 PMID:38103660 PMID:38220133 PMID:38326183 PMID:39154867 PMID:39454710 More...
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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G
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Tfam
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transcription factor A, mitochondrial
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Nanotubes, Carbon results in decreased expression of TFAM protein]
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CTD |
PMID:39033796 |
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NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
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G
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Tfeb
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transcription factor EB
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [nuciferine affects the localization of TFEB protein]
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CTD |
PMID:37126988 |
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NCBI chr 9:13,198,890...13,254,726
Ensembl chr 9:13,198,891...13,254,714
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G
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Th
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tyrosine hydroxylase
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [fenvalerate results in decreased expression of TH protein]; 3-methyladenine inhibits the reaction [Oxidopamine results in decreased expression of TH protein]
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CTD |
PMID:28802652 PMID:31734597 |
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NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
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G
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Tnf
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tumor necrosis factor
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multiple interactions increases expression
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ISO EXP
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3-methyladenine inhibits the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; 3-methyladenine inhibits the reaction [Particulate Matter results in increased secretion of TNF protein]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; 3-methyladenine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; [3-methyladenine co-treated with TNF protein] results in decreased expression of MAP1LC3B protein alternative form 3-methyladenine inhibits the reaction [anemoside B4 inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]]; 3-methyladenine inhibits the reaction [nuciferine results in decreased expression of TNF protein] 3-methyladenine results in increased expression of TNF mRNA 3-methyladenine inhibits the reaction [lead acetate results in increased expression of TNF protein]; 3-methyladenine promotes the reaction [[Zearalenone co-treated with Lipopolysaccharides] results in increased expression of TNF protein]
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CTD |
PMID:24145604 PMID:29781141 PMID:31513885 PMID:31586597 PMID:32879255 PMID:34051206 PMID:37126988 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G
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Tnnt2
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troponin T2, cardiac type
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multiple interactions
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EXP
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3-methyladenine inhibits the reaction [citreoviridin results in increased secretion of TNNT2 protein]
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CTD |
PMID:31419397 |
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NCBI chr13:47,267,325...47,285,390
Ensembl chr13:47,267,204...47,285,388
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G
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Tomm20
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translocase of outer mitochondrial membrane 20
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [Doxorubicin results in decreased expression of TOMM20 protein]
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CTD |
PMID:31226464 |
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NCBI chr19:71,822,429...71,832,420
Ensembl chr19:54,923,402...54,935,198
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G
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Tp53
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tumor protein p53
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TP53 protein]]; 3-methyladenine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; [3-methyladenine co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein 3-methyladenine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in increased phosphorylation of TRP53 protein]]
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CTD |
PMID:22927544 PMID:23380477 PMID:30555576 |
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G
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Tp53bp2
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tumor protein p53 binding protein, 2
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multiple interactions
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ISO
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TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of GPT protein]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL1B mRNA]; TRP53BP2 protein affects the reaction [3-methyladenine results in increased expression of IL6 mRNA]
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CTD |
PMID:31513885 |
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NCBI chr13:94,088,769...94,145,436
Ensembl chr13:94,088,709...94,145,432
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G
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Ulk1
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unc-51 like autophagy activating kinase 1
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multiple interactions decreases expression increases phosphorylation
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EXP ISO
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3-methyladenine affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]; 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; 3-methyladenine inhibits the reaction [2,5,2',5'-tetrachlorobiphenyl results in increased expression of ULK1 protein] 3-methyladenine inhibits the reaction [isobavachin results in increased phosphorylation of ULK1 protein] 3-methyladenine results in decreased expression of ULK1 protein 3-methyladenine results in increased phosphorylation of ULK1 protein 3-methyladenine inhibits the reaction [2,4,4'-trichlorobiphenyl results in increased expression of ULK1 protein]; 3-methyladenine inhibits the reaction [[Diosgenin co-treated with alpha-Chlorohydrin] results in decreased phosphorylation of ULK1 protein]; Alpha-Amanitin inhibits the reaction [3-methyladenine results in decreased expression of ULK1 protein]
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CTD |
PMID:29128638 PMID:29518472 PMID:35149085 PMID:37329965 PMID:39154867 |
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NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966
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G
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Vegfa
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vascular endothelial growth factor A
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multiple interactions
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ISO
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3-methyladenine inhibits the reaction [nuciferine results in increased expression of VEGFA protein]
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CTD |
PMID:37126988 |
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NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G
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Wnt3a
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Wnt family member 3A
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multiple interactions
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ISO
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3-methyladenine promotes the reaction [T-2 Toxin results in decreased expression of WNT3A protein]
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CTD |
PMID:36402210 |
|
NCBI chr10:44,533,734...44,577,919
Ensembl chr10:44,034,194...44,078,324
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|
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G
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Agt
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angiotensinogen
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multiple interactions
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EXP
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bafilomycin A1 inhibits the reaction [AGT protein affects the localization of Calcium]
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CTD |
PMID:21613610 |
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NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
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G
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Aim2
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absent in melanoma 2
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multiple interactions
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ISO
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[bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of AIM2 protein
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CTD |
PMID:32645460 |
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NCBI chr13:85,865,206...85,906,996
Ensembl chr13:85,866,284...85,906,975
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G
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Akt1s1
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AKT1 substrate 1
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multiple interactions
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EXP
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bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
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CTD |
PMID:22689575 PMID:37914286 |
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NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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G
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Alb
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albumin
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decreases uptake
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ISO
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bafilomycin A1 results in decreased uptake of ALB protein
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CTD |
PMID:16313995 |
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NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,607,381...17,622,836
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G
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Apaf1
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apoptotic peptidase activating factor 1
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increases expression
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ISO
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bafilomycin A1 results in increased expression of APAF1 protein
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CTD |
PMID:28483490 |
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NCBI chr 7:27,381,392...27,466,772
Ensembl chr 7:25,494,609...25,579,540
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G
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Appl1
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adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
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multiple interactions
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ISO
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bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased degradation of APPL1 protein]
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CTD |
PMID:25780039 |
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NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,121,255...2,166,692
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G
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Arf6
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ARF GTPase 6
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multiple interactions
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EXP
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bafilomycin A1 inhibits the reaction [maduramicin results in decreased expression of ARF6 protein]
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CTD |
PMID:37394175 |
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NCBI chr 6:93,589,777...93,590,925
Ensembl chr 6:87,840,142...87,874,114
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G
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Asic1
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acid sensing ion channel subunit 1
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Freund's Adjuvant results in increased expression of ASIC1 mRNA]
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CTD |
PMID:16769263 |
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NCBI chr 7:130,798,317...130,828,535
Ensembl chr 7:130,799,917...130,828,541
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G
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Atg5
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autophagy related 5
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multiple interactions
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ISO
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ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]] [bafilomycin A1 co-treated with Swainsonine] results in increased expression of ATG5 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of ATG5 protein
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CTD |
PMID:29938581 PMID:36402259 |
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NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
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G
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Bax
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BCL2 associated X, apoptosis regulator
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein]
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CTD |
PMID:12813466 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G
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Bcl2
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BCL2, apoptosis regulator
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decreases expression multiple interactions
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ISO EXP
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bafilomycin A1 results in decreased expression of BCL2 mRNA bafilomycin A1 promotes the reaction [Methamphetamine results in decreased expression of BCL2 protein]
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CTD |
PMID:31310755 PMID:34374793 |
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G
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Becn1
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beclin 1
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multiple interactions increases expression
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ISO EXP
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bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of BECN1 protein] [Swainsonine co-treated with bafilomycin A1] results in increased expression of BECN1 protein; bafilomycin A1 promotes the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of BECN1 protein] bafilomycin A1 results in increased expression of BECN1 protein
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CTD |
PMID:32645460 PMID:33186601 PMID:33242459 |
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NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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G
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Bglap
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bone gamma-carboxyglutamate protein
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
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CTD |
PMID:23111315 |
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NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
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G
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Bid
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BH3 interacting domain death agonist
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multiple interactions increases cleavage increases expression
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EXP ISO
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bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein modified form]; bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of BID protein] vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of BID protein] bafilomycin A1 results in increased expression of BID protein modified form
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CTD |
PMID:26853465 PMID:28378122 |
|
NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720
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G
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Bnip3
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BCL2 interacting protein 3
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increases expression multiple interactions
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ISO
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bafilomycin A1 results in increased expression of BNIP3 mRNA; bafilomycin A1 results in increased expression of BNIP3 protein BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; capivasertib affects the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Erlotinib Hydrochloride inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; Gefitinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]; HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; Lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; vistusertib inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 protein]
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CTD |
PMID:25981168 PMID:26853465 |
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NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
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G
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Casp3
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caspase 3
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decreases activity increases cleavage multiple interactions increases activity
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ISO EXP
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bafilomycin A1 results in decreased activity of CASP3 protein bafilomycin A1 results in increased cleavage of CASP3 protein bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein] bafilomycin A1 results in increased activity of CASP3 protein [Swainsonine co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein; bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of CASP3 protein modified form]; bafilomycin A1 promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein] [bafilomycin A1 co-treated with Cannabidiol] results in increased cleavage of CASP3 protein; [bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; [bafilomycin A1 co-treated with methanandamide] results in increased cleavage of CASP3 protein; [Cannabidiol co-treated with bafilomycin A1] results in increased cleavage of CASP3 protein; bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP3 protein]; bafilomycin A1 inhibits the reaction [tetrandrine results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of CASP3 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased activity of CASP3 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [[bafilomycin A1 co-treated with Cannabidiol] results in increased cleavage of CASP3 protein]; tin protoporphyrin IX inhibits the reaction [[bafilomycin A1 co-treated with methanandamide] results in increased cleavage of CASP3 protein]; vistusertib affects the reaction [bafilomycin A1 results in increased cleavage of CASP3 protein]
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CTD |
PMID:20876807 PMID:23380477 PMID:24321340 PMID:24889822 PMID:25266202 PMID:25981168 PMID:26853465 PMID:28063998 PMID:28378122 PMID:29111403 PMID:30240709 PMID:32708634 PMID:33076330 PMID:33186601 PMID:34374793 More...
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G
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Casp4
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caspase 4
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increases activity
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ISO
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bafilomycin A1 results in increased activity of CASP4 protein
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CTD |
PMID:20371669 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G
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Casp7
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caspase 7
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increases activity decreases activity
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ISO
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bafilomycin A1 results in increased activity of CASP7 protein bafilomycin A1 results in decreased activity of CASP7 protein
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CTD |
PMID:20371669 PMID:25981168 |
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NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G
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Casp8
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caspase 8
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multiple interactions
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EXP ISO
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bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP8 protein] bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
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CTD |
PMID:28378122 PMID:29111403 |
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NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G
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Casp9
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caspase 9
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multiple interactions
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EXP ISO
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bafilomycin A1 inhibits the reaction [manganese chloride results in increased cleavage of CASP9 protein] bafilomycin A1 inhibits the reaction [Soot analog results in increased expression of CASP9 protein]
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CTD |
PMID:28378122 PMID:30240709 |
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Ensembl chr 5:154,109,046...154,126,626
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G
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Ccnd1
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cyclin D1
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of CCND1 protein]
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CTD |
PMID:33359579 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G
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Cdc25c
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cell division cycle 25C
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [xanthatin results in decreased stability of CDC25C protein]
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CTD |
PMID:29074359 |
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NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
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G
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Cdh1
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cadherin 1
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Capsaicin results in increased expression of CDH1 protein]
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CTD |
PMID:36044967 |
|
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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G
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Cdh2
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cadherin 2
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Capsaicin results in decreased expression of CDH2 protein]
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CTD |
PMID:36044967 |
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NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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G
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Ctsb
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cathepsin B
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]; bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein]
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CTD |
PMID:12813466 PMID:23380477 |
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NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
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G
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Ctsd
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cathepsin D
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decreases cleavage
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ISO
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bafilomycin A1 results in decreased cleavage of CTSD protein
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CTD |
PMID:36070022 |
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NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
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G
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Ctsl
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cathepsin L
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decreases cleavage
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ISO
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bafilomycin A1 results in decreased cleavage of CTSL protein
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CTD |
PMID:36070022 |
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NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
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G
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Cxcl10
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C-X-C motif chemokine ligand 10
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multiple interactions
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ISO
|
bafilomycin A1 inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; bafilomycin A1 inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]
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CTD |
PMID:26682054 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G
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Ddit4
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DNA-damage-inducible transcript 4
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increases expression multiple interactions
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EXP
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bafilomycin A1 results in increased expression of DDIT4 protein [EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein
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CTD |
PMID:22689575 |
|
NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105
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G
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Deptor
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DEP domain containing MTOR-interacting protein
|
multiple interactions
|
EXP
|
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
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CTD |
PMID:37914286 |
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NCBI chr 7:86,514,859...86,668,817
Ensembl chr 7:86,514,988...86,667,773
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G
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Egf
|
epidermal growth factor
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multiple interactions
|
EXP
|
[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine; [bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Aspartic Acid; [bafilomycin A1 co-treated with EGF protein] results in increased abundance of Taurine; [EGF protein co-treated with bafilomycin A1] results in increased expression of DDIT4 protein; bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Arginine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Asparagine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Isoleucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Leucine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Lysine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Methionine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Ornithine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Phenylalanine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Tyrosine]; Cycloheximide inhibits the reaction [[bafilomycin A1 co-treated with EGF protein] results in decreased abundance of Valine]
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CTD |
PMID:22689575 |
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NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
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G
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Egfr
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epidermal growth factor receptor
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Arsenic Trioxide results in decreased expression of EGFR protein]
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CTD |
PMID:30237564 |
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NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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G
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Eif4ebp1
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eukaryotic translation initiation factor 4E binding protein 1
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multiple interactions
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EXP
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bafilomycin A1 inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein]
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CTD |
PMID:22689575 |
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NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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G
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Epor
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erythropoietin receptor
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Aristolochic Acids results in increased degradation of and results in decreased expression of EPOR protein]
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CTD |
PMID:26136230 |
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NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:20,489,678...20,494,257
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G
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Faslg
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Fas ligand
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multiple interactions
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ISO EXP
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bafilomycin A1 inhibits the reaction [FASL protein affects the localization of Calcium] bafilomycin A1 inhibits the reaction [manganese chloride results in increased expression of FASLG protein]
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CTD |
PMID:20200208 PMID:28378122 |
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NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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G
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Fmc1
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formation of mitochondrial complex V assembly factor 1
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Carbonyl Cyanide m-Chlorophenyl Hydrazone results in decreased expression of FMC1 protein]
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CTD |
PMID:29371327 |
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NCBI chr 4:67,274,104...67,282,140
Ensembl chr 4:67,274,104...67,282,140
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G
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Foxo1
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forkhead box O1
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multiple interactions
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EXP
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bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in increased acetylation of FOXO1 protein]]
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CTD |
PMID:24889822 |
|
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
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G
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Fth1
|
ferritin heavy chain 1
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multiple interactions
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ISO
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bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]
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CTD |
PMID:37951334 |
|
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
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G
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Ftl1
|
ferritin light chain 1
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multiple interactions
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ISO
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bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]
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CTD |
PMID:37951334 |
|
NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
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G
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Gja1
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gap junction protein, alpha 1
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increases expression
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ISO
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bafilomycin A1 results in increased expression of GJA1 protein
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CTD |
PMID:35750204 |
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NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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G
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Hif1a
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hypoxia inducible factor 1 subunit alpha
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increases expression multiple interactions
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ISO
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bafilomycin A1 results in increased expression of HIF1A protein HIF1A mutant form inhibits the reaction [bafilomycin A1 results in increased expression of BNIP3 mRNA]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; lapatinib inhibits the reaction [bafilomycin A1 results in increased expression of HIF1A protein]
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CTD |
PMID:25981168 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G
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Hmox1
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heme oxygenase 1
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decreases expression multiple interactions
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ISO
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bafilomycin A1 results in decreased expression of HMOX1 protein [bafilomycin A1 co-treated with methanandamide] results in increased expression of HMOX1 protein; [bafilomycin A1 co-treated with tin protoporphyrin IX] promotes the reaction [Cannabidiol results in increased expression of HMOX1 protein]; bafilomycin A1 inhibits the reaction [4-(4-fluorophenyl)-2-(4-hydroxyphenyl)-5-(4-pyridyl)imidazole results in increased expression of HMOX1 protein]
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CTD |
PMID:29796178 PMID:33076330 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G
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Ifng
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interferon gamma
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decreases expression
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ISO
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bafilomycin A1 results in decreased expression of IFNG mRNA
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CTD |
PMID:16932910 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G
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Il1b
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interleukin 1 beta
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decreases expression multiple interactions
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ISO
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bafilomycin A1 results in decreased expression of IL1B mRNA [bafilomycin A1 co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in increased expression of IL1B protein; bafilomycin A1 inhibits the reaction [[Tetradecanoylphorbol Acetate co-treated with aluminum sulfate] results in increased secretion of IL1B protein]
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CTD |
PMID:16932910 PMID:24158569 PMID:32645460 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G
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Il6
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interleukin 6
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increases expression
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ISO
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bafilomycin A1 results in increased expression of IL6 mRNA
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CTD |
PMID:16932910 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G
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Ins1
|
insulin 1
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multiple interactions
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ISO
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bafilomycin A1 promotes the reaction [Palmitic Acid inhibits the reaction [INS1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose]]
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CTD |
PMID:32283200 |
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NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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G
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Ins2
|
insulin 2
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multiple interactions
|
EXP
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bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of EIF4EBP1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
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CTD |
PMID:22689575 |
|
NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G
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Keap1
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Kelch-like ECH-associated protein 1
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multiple interactions
|
ISO
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bafilomycin A1 promotes the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]]
|
CTD |
PMID:35123989 |
|
NCBI chr 8:28,044,555...28,054,042
Ensembl chr 8:19,768,375...19,777,862
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G
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Lamp1
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lysosomal-associated membrane protein 1
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multiple interactions increases expression
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ISO
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[bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased expression of LAMP1 protein bafilomycin A1 results in increased expression of LAMP1 protein
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CTD |
PMID:36402259 |
|
NCBI chr16:83,058,131...83,082,843
Ensembl chr16:76,355,984...76,381,883
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G
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Lcat
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lecithin cholesterol acyltransferase
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multiple interactions
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EXP
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bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form]
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CTD |
PMID:32278738 |
|
NCBI chr19:50,744,598...50,748,064
Ensembl chr19:33,834,403...33,838,231
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G
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Lrrk2
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leucine-rich repeat kinase 2
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increases response to substance
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ISO
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LRRK2 gene mutant form results in increased susceptibility to bafilomycin A1
|
CTD |
PMID:25017139 |
|
NCBI chr 7:124,706,246...124,867,234
Ensembl chr 7:122,826,696...122,987,703
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G
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Man2a1
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mannosidase, alpha, class 2A, member 1
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2A1 mRNA]
|
CTD |
PMID:36402259 |
|
NCBI chr 9:104,252,001...104,408,349
Ensembl chr 9:104,252,001...104,408,349
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G
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Man2b1
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mannosidase, alpha, class 2B, member 1
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multiple interactions
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ISO
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bafilomycin A1 inhibits the reaction [Swainsonine results in decreased expression of MAN2B1 mRNA]
|
CTD |
PMID:36402259 |
|
NCBI chr19:23,055,092...23,074,398
Ensembl chr19:23,055,097...23,074,389
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G
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Map1lc3a
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microtubule-associated protein 1 light chain 3 alpha
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multiple interactions increases expression
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ISO EXP
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bafilomycin A1 promotes the reaction [Uranium results in increased expression of MAP1LC3A protein] bafilomycin A1 inhibits the reaction [Lidocaine results in increased expression of MAP1LC3A protein] bafilomycin A1 results in increased expression of MAP1LC3A protein modified form
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CTD |
PMID:30871063 PMID:31120128 PMID:37914286 |
|
NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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G
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Map1lc3b
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microtubule-associated protein 1 light chain 3 beta
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multiple interactions increases lipidation increases expression increases cleavage decreases degradation
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ISO EXP
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[bafilomycin A1 co-treated with Miconazole] results in increased expression of MAP1LC3B protein; [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1] results in increased expression of MAP1LC3B mRNA; [TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; Acetylcysteine inhibits the reaction [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]]; ATG5 protein affects the reaction [bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]]; bafilomycin A1 affects the reaction [Ammonium Chloride results in increased metabolism of MAP1LC3B protein]; bafilomycin A1 affects the reaction [AZD4547 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 affects the reaction [AZD8186 affects the expression of MAP1LC3B protein modified form]; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [[alpha-Chlorohydrin co-treated with Diosgenin] results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [capivasertib results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [Curcumin results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [gossypol acetic acid results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [metarrestin results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 promotes the reaction [Miconazole results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Particulate Matter results in increased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Resveratrol results in increased expression of MAP1LC3B protein alternative form]; bafilomycin A1 promotes the reaction [Sevoflurane results in increased lipidation of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [vistusertib results in increased expression of MAP1LC3B protein modified form]; bafilomycin A1 results in increased expression of and results in increased lipidation of MAP1LC3B protein; di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone promotes the reaction [bafilomycin A1 results in increased expression of MAP1LC3B protein]; Resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form] bafilomycin A1 results in increased lipidation of MAP1LC3B protein [Doxorubicin co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein; [Glycyrrhizic Acid co-treated with bafilomycin A1] results in increased lipidation of MAP1LC3B protein; bafilomycin A1 inhibits the reaction [olaparib inhibits the reaction [Hydrogen Peroxide results in increased lipidation of MAP1LC3B protein]]; bafilomycin A1 promotes the reaction [C1QTNF9 protein results in increased expression of MAP1LC3B protein modified form] bafilomycin A1 results in increased expression of MAP1LC3B protein modified form [bafilomycin A1 co-treated with Swainsonine] results in increased expression of MAP1LC3B mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of MAP1LC3B protein; bafilomycin A1 promotes the reaction [tricalcium phosphate results in increased expression of MAP1LC3B protein]; bafilomycin A1 promotes the reaction [Triiodothyronine results in increased lipidation of MAP1LC3B protein]; Triiodothyronine promotes the reaction [bafilomycin A1 results in increased lipidation of MAP1LC3B protein] bafilomycin A1 results in increased cleavage of MAP1LC3B protein bafilomycin A1 results in decreased degradation of MAP1LC3B protein modified form bafilomycin A1 results in increased expression of MAP1LC3B protein; bafilomycin A1 results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 results in increased expression of MAP1LC3B protein modified form
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CTD |
PMID:23880069 PMID:24145604 PMID:25301941 PMID:26459185 PMID:26853465 PMID:27305347 PMID:29248574 PMID:29524503 PMID:29908302 PMID:29938581 PMID:30209975 PMID:31310755 PMID:32278738 PMID:32525084 PMID:32981224 PMID:33124469 PMID:34580807 PMID:34634291 PMID:35149085 PMID:35472370 PMID:35872226 PMID:36070022 PMID:36402259 PMID:36639873 PMID:37678662 PMID:38000454 More...
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NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G
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Mapk1
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mitogen activated protein kinase 1
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multiple interactions increases expression
|
ISO
|
bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK1 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK1 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein] bafilomycin A1 results in increased expression of MAPK1 protein modified form
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CTD |
PMID:20371669 PMID:28483490 PMID:32645460 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G
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Mapk3
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mitogen activated protein kinase 3
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multiple interactions increases expression
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ISO
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bafilomycin A1 inhibits the reaction [Capsaicin results in increased activity of MAPK3 protein]; bafilomycin A1 inhibits the reaction [Iron Compounds results in increased expression of MAPK3 protein modified form]; bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK3 protein] bafilomycin A1 results in increased expression of MAPK3 protein modified form
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CTD |
PMID:20371669 PMID:28483490 PMID:32645460 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
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Mapk8
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mitogen-activated protein kinase 8
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increases phosphorylation
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ISO
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bafilomycin A1 results in increased phosphorylation of MAPK8 protein
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CTD |
PMID:31310755 |
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NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G
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Mlst8
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MTOR associated protein, LST8 homolog
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multiple interactions
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EXP
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bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
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CTD |
PMID:37914286 |
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NCBI chr10:13,498,377...13,504,128
Ensembl chr10:13,498,388...13,504,128
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G
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Mtor
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mechanistic target of rapamycin kinase
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decreases phosphorylation multiple interactions
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ISO EXP
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bafilomycin A1 results in decreased phosphorylation of MTOR protein bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
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CTD |
PMID:31310755 PMID:37914286 |
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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G
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Mttp
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microsomal triglyceride transfer protein
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increases expression
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ISO
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bafilomycin A1 results in increased expression of MTTP protein
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CTD |
PMID:34516972 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G
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Ncoa4
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nuclear receptor coactivator 4
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multiple interactions
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ISO
|
bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]
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CTD |
PMID:37951334 |
|
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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G
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Ndrg1
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N-myc downstream regulated 1
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multiple interactions
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ISO
|
NDRG1 protein results in decreased susceptibility to [di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone co-treated with bafilomycin A1]
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CTD |
PMID:24532803 |
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NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
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G
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Nfe2l2
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NFE2 like bZIP transcription factor 2
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multiple interactions increases expression
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ISO
|
bafilomycin A1 promotes the reaction [[Particulate Matter co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [[Silicon Dioxide co-treated with Vitamin D] results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Particulate Matter results in increased expression of NFE2L2 protein]; bafilomycin A1 promotes the reaction [Silicon Dioxide results in increased expression of NFE2L2 protein] bafilomycin A1 results in increased expression of NFE2L2 protein
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CTD |
PMID:30698894 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G
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Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions increases expression
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ISO
|
bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of NLRP3 protein] bafilomycin A1 results in increased expression of NLRP3 protein
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CTD |
PMID:32645460 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G
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Nr5a1
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nuclear receptor subfamily 5, group A, member 1
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decreases expression
|
ISO
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bafilomycin A1 results in decreased expression of NR5A1 protein
|
CTD |
PMID:29524503 |
|
NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328
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G
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Parp1
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poly (ADP-ribose) polymerase 1
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multiple interactions increases cleavage increases expression
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ISO EXP
|
[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [Atorvastatin results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [brazilin results in increased expression of PARP1 protein modified form]; bafilomycin A1 promotes the reaction [Flavanones results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; BNIP3 mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; HIF1A mutant form promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein] bafilomycin A1 promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] bafilomycin A1 inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein] bafilomycin A1 results in increased expression of PARP1 protein modified form
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CTD |
PMID:20876807 PMID:21616090 PMID:24321340 PMID:25981168 PMID:28063998 PMID:29111403 PMID:31310755 PMID:34374793 PMID:35022897 More...
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G
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Pcna
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proliferating cell nuclear antigen
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multiple interactions
|
ISO
|
bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of PCNA mRNA]
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CTD |
PMID:33359579 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G
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Pink1
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PTEN induced kinase 1
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multiple interactions
|
EXP
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bafilomycin A1 inhibits the reaction [Lidocaine results in increased expression of PINK1 protein]
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CTD |
PMID:37914286 |
|
NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635
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G
|
Prkaa1
|
protein kinase AMP-activated catalytic subunit alpha 1
|
multiple interactions
|
ISO EXP
|
bafilomycin A1 inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PRKAA1 protein] bafilomycin A1 inhibits the reaction [Lidocaine results in increased phosphorylation of PRKAA1 protein]
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CTD |
PMID:37481222 PMID:37914286 |
|
NCBI chr 2:55,967,766...56,003,450
Ensembl chr 2:54,240,137...54,275,978
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G
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Prkaa2
|
protein kinase AMP-activated catalytic subunit alpha 2
|
multiple interactions
|
ISO
|
bafilomycin A1 inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of PRKAA2 protein]
|
CTD |
PMID:37481222 |
|
NCBI chr 5:125,036,945...125,109,010
Ensembl chr 5:119,813,226...119,879,543
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G
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Prkd2
|
protein kinase D2
|
multiple interactions
|
ISO
|
[PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]] which affects the abundance of Malondialdehyde; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; bafilomycin A1 affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; PRKD2 protein affects the susceptibility to [erastin co-treated with bafilomycin A1]
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CTD |
PMID:37951334 |
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NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:77,513,986...77,542,376
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions
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ISO
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bafilomycin A1 affects the localization of and results in increased activity of RELA protein
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CTD |
PMID:10339586 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G
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Rps6kb1
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ribosomal protein S6 kinase B1
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decreases phosphorylation multiple interactions
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ISO EXP
|
bafilomycin A1 results in decreased phosphorylation of RPS6KB1 protein bafilomycin A1 inhibits the reaction [EGF protein results in increased activity of and results in increased phosphorylation of RPS6KB1 protein]; bafilomycin A1 inhibits the reaction [INS protein results in increased phosphorylation of RPS6KB1 protein]
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CTD |
PMID:22689575 PMID:31310755 |
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NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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G
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Rptor
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regulatory associated protein of MTOR, complex 1
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multiple interactions
|
EXP
|
bafilomycin A1 inhibits the reaction [Lidocaine results in decreased expression of [MTOR protein binds to RPTOR protein binds to MLST8 protein binds to PRAS40 protein binds to DEPTOR protein]]
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CTD |
PMID:37914286 |
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NCBI chr10:105,376,943...105,675,416
Ensembl chr10:104,878,487...105,176,983
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G
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Runx2
|
RUNX family transcription factor 2
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multiple interactions
|
ISO
|
bafilomycin A1 inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA]
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CTD |
PMID:23111315 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
EXP
|
bafilomycin A1 inhibits the reaction [resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT1 protein]]
|
CTD |
PMID:24889822 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
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G
|
Slc17a7
|
solute carrier family 17 member 7
|
multiple interactions
|
EXP
|
bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Excitatory Amino Acid Agents]; bafilomycin A1 inhibits the reaction [SLC17A7 protein results in increased uptake of Zinc]; bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]]
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CTD |
PMID:15860731 |
|
NCBI chr 1:104,786,172...104,798,049
Ensembl chr 1:95,649,745...95,661,588
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G
|
Slc30a3
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solute carrier family 30 member 3
|
multiple interactions
|
EXP
|
bafilomycin A1 inhibits the reaction [SLC30A3 protein promotes the reaction [SLC17A7 protein results in increased uptake of Zinc]]
|
CTD |
PMID:15860731 |
|
NCBI chr 6:25,264,310...25,284,720
Ensembl chr 6:25,275,528...25,284,720
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G
|
Snai1
|
snail family transcriptional repressor 1
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multiple interactions increases expression
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ISO
|
bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein] bafilomycin A1 results in increased expression of SNAI1 protein
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CTD |
PMID:32645460 |
|
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
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|
G
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Snca
|
synuclein alpha
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multiple interactions increases expression
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ISO
|
[bafilomycin A1 co-treated with Rotenone] results in increased expression of SNCA protein bafilomycin A1 results in increased expression of SNCA protein
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CTD |
PMID:26031332 |
|
NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
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|
G
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Sort1
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sortilin 1
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decreases expression
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ISO
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bafilomycin A1 results in decreased expression of SORT1 protein
|
CTD |
PMID:25805502 |
|
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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G
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Sqstm1
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sequestosome 1
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increases expression multiple interactions
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ISO EXP
|
bafilomycin A1 results in increased expression of SQSTM1 protein bafilomycin A1 promotes the reaction [Hydrogen Peroxide results in increased expression of SQSTM1 protein] [Resveratrol co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; [Vitamin D co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; bafilomycin A1 inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Dexamethasone results in decreased expression of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; bafilomycin A1 inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [ginsenoside Rg2 results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [metarrestin results in decreased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [Miconazole results in increased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; bafilomycin A1 promotes the reaction [pachastrissamine analog promotes the reaction [KEAP1 protein binds to SQSTM1 protein]]; Fingolimod Hydrochloride affects the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; sodium arsenite promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein] [bafilomycin A1 co-treated with Rotenone] results in increased expression of SQSTM1 protein; [bafilomycin A1 co-treated with Swainsonine] results in increased expression of SQSTM1 mRNA; [bafilomycin A1 co-treated with Swainsonine] results in increased lipidation of SQSTM1 protein; bafilomycin A1 inhibits the reaction [Resveratrol inhibits the reaction [Streptozocin results in increased expression of SQSTM1 protein]]; bafilomycin A1 inhibits the reaction [Sirolimus results in decreased expression of SQSTM1 protein]; decamethrin promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]; Streptozocin promotes the reaction [bafilomycin A1 results in increased expression of SQSTM1 protein]
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CTD |
PMID:21778691 PMID:21858812 PMID:23151917 PMID:24145604 PMID:24238063 PMID:24889822 PMID:25939952 PMID:25943029 PMID:26031332 PMID:27305347 PMID:28125038 PMID:29248574 PMID:29524503 PMID:30698894 PMID:32186374 PMID:32645460 PMID:32981224 PMID:33124469 PMID:33359579 PMID:34405320 PMID:34520793 PMID:34580807 PMID:35123989 PMID:36070022 PMID:36402259 PMID:37481222 More...
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|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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|
G
|
Stk11
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serine/threonine kinase 11
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multiple interactions
|
ISO
|
bafilomycin A1 inhibits the reaction [2-chloroethyl ethyl sulfide results in decreased expression of STK11 protein]
|
CTD |
PMID:37481222 |
|
NCBI chr 7:10,225,204...10,241,965
Ensembl chr 7:9,575,269...9,591,315
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|
G
|
Tbk1
|
TANK-binding kinase 1
|
multiple interactions
|
ISO
|
bafilomycin A1 promotes the reaction [Lipopolysaccharides results in increased phosphorylation of TBK1 protein]; bafilomycin A1 promotes the reaction [Poly I-C results in increased phosphorylation of TBK1 protein]
|
CTD |
PMID:25780039 |
|
NCBI chr 7:58,963,319...58,996,357
Ensembl chr 7:57,077,830...57,110,892
|
|
G
|
Tlr8
|
toll-like receptor 8
|
multiple interactions
|
ISO
|
bafilomycin A1 inhibits the reaction [resiquimod results in increased activity of TLR8 protein]
|
CTD |
PMID:21398612 |
|
NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
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|
G
|
Tnf
|
tumor necrosis factor
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increases expression multiple interactions
|
ISO
|
bafilomycin A1 results in increased expression of TNF mRNA [TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form; [TNF protein co-treated with bafilomycin A1] results in increased expression of SQSTM1 protein; resveratrol promotes the reaction [[TNF protein co-treated with bafilomycin A1] results in increased expression of MAP1LC3B protein alternative form]
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CTD |
PMID:16932910 PMID:24145604 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G
|
Tomm20
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translocase of outer mitochondrial membrane 20
|
increases expression multiple interactions
|
ISO
|
bafilomycin A1 results in increased expression of TOMM20 protein Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of TOMM20 protein]
|
CTD |
PMID:30209975 |
|
NCBI chr19:71,822,429...71,832,420
Ensembl chr19:54,923,402...54,935,198
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|
G
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Tp53
|
tumor protein p53
|
multiple interactions
|
ISO
|
[bafilomycin A1 co-treated with cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CASP3 protein; bafilomycin A1 inhibits the reaction [[cobaltous chloride co-treated with TP53 gene mutant form] results in increased activity of CTSB protein]
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CTD |
PMID:23380477 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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|
G
|
Ulk1
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unc-51 like autophagy activating kinase 1
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multiple interactions
|
EXP
|
bafilomycin A1 affects the reaction [N-(1,3-benzodioxol-5-ylmethyl)-2,6-dichlorobenzamide affects the reaction [Glucose affects the phosphorylation of ULK1 protein]]
|
CTD |
PMID:29128638 |
|
NCBI chr12:51,511,492...51,537,746
Ensembl chr12:45,851,710...45,877,966
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G
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Usp8
|
ubiquitin specific peptidase 8
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multiple interactions
|
ISO
|
[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [bafilomycin A1 results in increased cleavage of PARP1 protein]; bafilomycin A1 promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]
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CTD |
PMID:35022897 |
|
NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666
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G
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Vdac1
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voltage-dependent anion channel 1
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multiple interactions increases expression
|
ISO
|
Triiodothyronine promotes the reaction [bafilomycin A1 results in increased expression of VDAC1 protein]
|
CTD |
PMID:30209975 |
|
NCBI chr10:37,029,377...37,060,542
Ensembl chr10:36,532,244...36,559,640
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|
G
|
Vdr
|
vitamin D receptor
|
multiple interactions
|
ISO
|
[bafilomycin A1 co-treated with Vitamin D] results in increased expression of VDR protein; [Silicon Dioxide co-treated with Vitamin D co-treated with bafilomycin A1] results in increased expression of VDR protein
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CTD |
PMID:30698894 |
|
NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
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G
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Vim
|
vimentin
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multiple interactions increases expression
|
ISO
|
bafilomycin A1 promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein] bafilomycin A1 results in increased expression of VIM protein
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CTD |
PMID:32645460 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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|
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G
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Abcb1a
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ATP binding cassette subfamily B member 1A
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decreases expression multiple interactions
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ISO
|
Chloroquine results in decreased expression of ABCB1 mRNA; Chloroquine results in decreased expression of ABCB1 protein Chloroquine results in decreased expression of ABCB1A mRNA [Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein; Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1A mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1A mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1A protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1A protein; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]] Bortezomib promotes the reaction [Chloroquine results in decreased expression of ABCB1 mRNA]; Bortezomib promotes the reaction [Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Bortezomib results in decreased expression of and results in increased nitrosation of ABCB1 protein]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 mRNA]; Chloroquine promotes the reaction [Cisplatin results in decreased expression of ABCB1 protein]; Chloroquine results in decreased expression of and results in increased nitrosation of ABCB1 protein
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CTD |
PMID:25987058 PMID:27692344 PMID:30482226 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G
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Abcc1
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ATP binding cassette subfamily C member 1
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decreases expression
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ISO
|
Chloroquine results in decreased expression of ABCC1 mRNA; Chloroquine results in decreased expression of ABCC1 protein
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CTD |
PMID:27692344 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
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G
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Abcc2
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ATP binding cassette subfamily C member 2
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decreases expression
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ISO
|
Chloroquine results in decreased expression of ABCC2 mRNA; Chloroquine results in decreased expression of ABCC2 protein
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CTD |
PMID:27692344 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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G
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Abcg2
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ATP binding cassette subfamily G member 2
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decreases expression
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ISO
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Chloroquine results in decreased expression of ABCG2 mRNA; Chloroquine results in decreased expression of ABCG2 protein
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CTD |
PMID:27692344 |
|
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
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G
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Abl1
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ABL proto-oncogene 1, non-receptor tyrosine kinase
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multiple interactions
|
ISO
|
Chloroquine promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; Chloroquine promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]
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CTD |
PMID:33070465 |
|
NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065
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G
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Acsl4
|
acyl-CoA synthetase long-chain family member 4
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multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Particulate Matter results in increased expression of ACSL4 protein]
|
CTD |
PMID:36700298 |
|
NCBI chr X:110,739,633...110,803,416
Ensembl chr X:105,942,799...106,006,427
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G
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Acta2
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actin alpha 2, smooth muscle
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multiple interactions
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EXP ISO
|
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of ACTA2 protein]] Chloroquine inhibits the reaction [sodium arsenite results in increased expression of ACTA2 protein]
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CTD |
PMID:35104487 PMID:38477077 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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G
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Akt1
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AKT serine/threonine kinase 1
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multiple interactions decreases phosphorylation
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ISO EXP
|
Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of AKT1 protein] Chloroquine results in decreased phosphorylation of AKT1 protein Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of and results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:24990399 PMID:27180204 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G
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Akt1s1
|
AKT1 substrate 1
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multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]
|
CTD |
PMID:22689575 |
|
NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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G
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Aldh1b1
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aldehyde dehydrogenase 1 family, member B1
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decreases expression
|
EXP
|
Chloroquine results in decreased expression of ALDH1B1 mRNA
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CTD |
PMID:19393257 |
|
NCBI chr 5:64,859,000...64,864,008
Ensembl chr 5:60,063,225...60,068,378
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|
G
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Angptl8
|
angiopoietin-like 8
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multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]
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CTD |
PMID:24262987 |
|
NCBI chr 8:20,376,462...20,378,488
Ensembl chr 8:20,376,462...20,378,490
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|
G
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Apod
|
apolipoprotein D
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affects localization
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ISO
|
Chloroquine affects the localization of APOD protein
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CTD |
PMID:28182653 |
|
NCBI chr11:69,431,261...69,452,306
Ensembl chr11:69,431,260...69,452,305
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G
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Apoe
|
apolipoprotein E
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affects localization
|
EXP
|
Chloroquine affects the localization of APOE protein
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CTD |
PMID:8616629 |
|
NCBI chr 1:88,481,889...88,485,816
Ensembl chr 1:79,353,916...79,357,932
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G
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App
|
amyloid beta precursor protein
|
affects expression increases expression affects localization multiple interactions
|
EXP
|
Chloroquine affects the expression of APP mRNA; Chloroquine affects the expression of APP protein Chloroquine results in increased expression of APP protein Chloroquine affects the localization of APP protein Chloroquine affects the localization of and affects the cleavage of APP protein
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CTD |
PMID:7715800 PMID:8616629 PMID:8787835 PMID:9690670 |
|
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G
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Appl1
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adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Lipopolysaccharides results in increased degradation of APPL1 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased degradation of APPL1 protein]
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CTD |
PMID:25780039 |
|
NCBI chr16:2,125,234...2,173,457
Ensembl chr16:2,121,255...2,166,692
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G
|
Aqp2
|
aquaporin 2
|
decreases degradation multiple interactions decreases expression
|
ISO
|
Chloroquine results in decreased degradation of AQP2 protein Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein] Chloroquine results in decreased expression of AQP2 protein
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CTD |
PMID:21734099 PMID:22791344 |
|
NCBI chr 7:132,590,286...132,595,321
Ensembl chr 7:130,711,413...130,716,468
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G
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Aqp5
|
aquaporin 5
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Cyclic AMP results in decreased expression of AQP5 protein]
|
CTD |
PMID:15536076 |
|
NCBI chr 7:130,722,675...130,726,207
Ensembl chr 7:130,721,748...130,726,209
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G
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Ar
|
androgen receptor
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein alternative form]; Chloroquine inhibits the reaction [Riluzole results in increased degradation of and results in decreased expression of AR protein]
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CTD |
PMID:30280407 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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G
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Arcn1
|
archain 1
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affects localization
|
ISO
|
Chloroquine affects the localization of ARCN1 protein
|
CTD |
PMID:29940786 |
|
NCBI chr 8:45,057,617...45,082,224
Ensembl chr 8:45,057,619...45,082,247
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G
|
Ass1
|
argininosuccinate synthase 1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of ASS1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 3:14,747,355...14,796,909
Ensembl chr 3:14,747,368...14,796,903
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G
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Atf4
|
activating transcription factor 4
|
multiple interactions
|
EXP
|
Chloroquine promotes the reaction [cadmium acetate results in increased expression of ATF4 protein]
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CTD |
PMID:29870746 |
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NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
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G
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Atg5
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autophagy related 5
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multiple interactions increases expression
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ISO EXP
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Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of ATG5 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of ATG5 protein] Chloroquine results in increased expression of ATG5 protein Chloroquine inhibits the reaction [cadmium acetate results in increased expression of ATG5 protein]
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CTD |
PMID:28184909 PMID:29870746 PMID:30338810 |
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NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
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G
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Atm
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ATM serine/threonine kinase
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increases phosphorylation
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ISO
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Chloroquine results in increased phosphorylation of ATM protein
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CTD |
PMID:18089834 |
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NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
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G
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Atp1a1
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ATPase Na+/K+ transporting subunit alpha 1
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multiple interactions increases expression
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EXP ISO
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Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of ATP1A1 protein] Chloroquine results in increased expression of ATP1A1 protein
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CTD |
PMID:10506578 PMID:26750564 |
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NCBI chr 2:191,709,311...191,737,414
Ensembl chr 2:189,020,722...189,048,837
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G
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Avp
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arginine vasopressin
|
multiple interactions
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ISO
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Chloroquine inhibits the reaction [AVP protein affects the localization of AQP2 protein]; Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein]
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CTD |
PMID:22791344 |
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NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
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G
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Bax
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BCL2 associated X, apoptosis regulator
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multiple interactions
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ISO EXP
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BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein] Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of BAX protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of BAX protein]] Chloroquine affects the folding of and results in increased activity of BAX protein; Chloroquine inhibits the reaction [formosanin C results in increased expression of BAX protein]; Chloroquine promotes the reaction [dactolisib affects the folding of and results in increased activity of BAX protein]; dactolisib promotes the reaction [Chloroquine affects the folding of and results in increased activity of BAX protein]
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CTD |
PMID:11589424 PMID:23151917 PMID:27180204 PMID:28713934 PMID:33684387 PMID:35104487 More...
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|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G
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Bbc3
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Bcl-2 binding component 3
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increases expression
|
ISO
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Chloroquine results in increased expression of BBC3 mRNA
|
CTD |
PMID:31310755 |
|
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
|
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G
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Bcl2
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BCL2, apoptosis regulator
|
multiple interactions
|
ISO EXP
|
Chloroquine inhibits the reaction [formosanin C results in decreased expression of BCL2 protein] Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BCL2 protein]]
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CTD |
PMID:27180204 PMID:28713934 PMID:35104487 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G
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Bcl2l1
|
Bcl2-like 1
|
multiple interactions increases expression
|
ISO
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BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein] Chloroquine results in increased expression of BCL2L1 mRNA
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CTD |
PMID:11589424 PMID:31310755 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G
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Becn1
|
beclin 1
|
multiple interactions decreases expression
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ISO EXP
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Carboplatin promotes the reaction [Chloroquine results in decreased expression of BECN1 protein]; Chloroquine inhibits the reaction [Cisplatin results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of BECN1 protein]; Chloroquine promotes the reaction [ABL1 protein mutant form binds to BECN1 protein]; Chloroquine promotes the reaction [Carboplatin results in decreased expression of BECN1 protein]; Chloroquine promotes the reaction [XPO1 protein binds to BECN1 protein] Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of BECN1 mRNA]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased expression of BECN1 protein] Chloroquine inhibits the reaction [cadmium acetate results in increased expression of BECN1 protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of BECN1 protein]] Chloroquine results in decreased expression of BECN1 mRNA; Chloroquine results in decreased expression of BECN1 protein
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CTD |
PMID:25987058 PMID:27692344 PMID:28184909 PMID:29870746 PMID:31862506 PMID:33070465 PMID:35104487 PMID:35843418 More...
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|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
|
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G
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Bglap
|
bone gamma-carboxyglutamate protein
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of BGLAP mRNA]
|
CTD |
PMID:23111315 |
|
NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
|
|
G
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Birc5
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baculoviral IAP repeat-containing 5
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [sunitinib results in decreased expression of BIRC5 protein] Chloroquine promotes the reaction [Immunologic Factors results in decreased expression of BIRC5 protein]
|
CTD |
PMID:24751611 PMID:27823620 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
|
|
G
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Bmp2
|
bone morphogenetic protein 2
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Benzo(a)pyrene results in decreased expression of BMP2 mRNA]; Chloroquine inhibits the reaction [Benzo(a)pyrene results in decreased expression of BMP2 protein]
|
CTD |
PMID:39454710 |
|
NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
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G
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Bnip3
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BCL2 interacting protein 3
|
multiple interactions increases expression
|
ISO
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vistusertib inhibits the reaction [Chloroquine results in increased expression of BNIP3 protein]
|
CTD |
PMID:26853465 |
|
NCBI chr 1:203,137,778...203,154,962
Ensembl chr 1:193,708,167...193,725,359
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|
G
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Btrc
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beta-transducin repeat containing E3 ubiquitin protein ligase
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax co-treated with hydroquinone] results in decreased expression of BTRC mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of BTRC protein]
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CTD |
PMID:35561756 |
|
NCBI chr 1:254,159,085...254,324,819
Ensembl chr 1:244,210,314...244,376,721
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G
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Calr
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calreticulin
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increases expression multiple interactions
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ISO
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Chloroquine results in increased expression of CALR mRNA [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein; [Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Chloroquine results in increased expression of and affects the localization of CALR protein; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; Doxorubicin promotes the reaction [Chloroquine affects the localization of CALR protein] [Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]
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CTD |
PMID:30482226 |
|
NCBI chr19:40,213,367...40,218,262
Ensembl chr19:23,308,351...23,313,414
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G
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Casp12
|
caspase 12
|
multiple interactions
|
EXP
|
Chloroquine promotes the reaction [cadmium acetate results in increased expression of CASP12 protein]
|
CTD |
PMID:29870746 |
|
NCBI chr 8:10,927,188...10,954,442
Ensembl chr 8:2,642,434...2,674,037
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G
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Casp3
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caspase 3
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multiple interactions increases cleavage increases expression increases activity
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ISO EXP
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1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein; [Rotenone co-treated with Chloroquine] results in increased cleavage of CASP3 protein; BAX mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]; BCL2L1 mutant form promotes the reaction [Chloroquine results in increased activity of CASP3 protein]; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased expression of CASP3 protein modified form]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein modified form]; Chloroquine promotes the reaction [Sunitinib results in increased activity of CASP3 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein] Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [trichostatin A inhibits the reaction [Cisplatin results in increased activity of CASP3 protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of CASP3 protein]]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of CASP3 protein] Chloroquine results in increased expression of CASP3 protein 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased cleavage of CASP3 protein]; [aloxistatin co-treated with pepstatin] inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; [Bortezomib co-treated with Chloroquine] results in increased cleavage of CASP3 protein; [capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein; [Chloroquine co-treated with aumolertinib] results in increased cleavage of CASP3 protein; [Chloroquine co-treated with vandetanib] results in increased activity of CASP3 protein; [vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[capivasertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; CA 074 methyl ester inhibits the reaction [[vistusertib co-treated with Chloroquine] results in increased activity of CASP3 protein]; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [betulin results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Biological Products results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP3 protein]; Chloroquine inhibits the reaction [formosanin C results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Amiodarone results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Biological Products results in increased expression of and results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [Cisplatin results in increased expression of CASP3 protein]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of CASP3 protein]; Chloroquine promotes the reaction [usnic acid results in increased activity of CASP3 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased cleavage of CASP3 protein]
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CTD |
PMID:11589424 PMID:23151917 PMID:23799852 PMID:24751611 PMID:25078063 PMID:25266202 PMID:25987058 PMID:26847702 PMID:26853465 PMID:27180204 PMID:28219700 PMID:28906492 PMID:29111403 PMID:29476062 PMID:30338810 PMID:30465897 PMID:30482226 PMID:30985881 PMID:31332898 PMID:31676321 PMID:32190974 PMID:32651653 PMID:33684387 PMID:34219533 PMID:34374793 PMID:35104487 PMID:37741534 More...
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G
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Casp7
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caspase 7
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multiple interactions
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ISO
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Chloroquine promotes the reaction [usnic acid results in increased activity of CASP7 protein]
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CTD |
PMID:25078063 |
|
NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G
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Casp8
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caspase 8
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increases cleavage multiple interactions
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ISO
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Chloroquine results in increased cleavage of CASP8 protein Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP8 protein] Chloroquine inhibits the reaction [Cadmium results in increased cleavage of CASP8 protein]
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CTD |
PMID:27692344 PMID:28906492 PMID:29111403 |
|
NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G
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Casp9
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caspase 9
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multiple interactions increases cleavage
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ISO
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[Chloroquine co-treated with vandetanib] results in increased activity of CASP9 protein; Chloroquine inhibits the reaction [hydroxyethyl methacrylate results in increased expression of CASP9 mRNA]; Chloroquine promotes the reaction [dactolisib results in increased cleavage of CASP9 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP9 protein]; dactolisib promotes the reaction [Chloroquine results in increased cleavage of CASP9 protein]
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CTD |
PMID:23151917 PMID:23799852 PMID:28184909 PMID:28906492 |
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Ensembl chr 5:154,109,046...154,126,626
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G
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Casr
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calcium-sensing receptor
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multiple interactions
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EXP
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Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of CASR protein]
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CTD |
PMID:32956540 |
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NCBI chr11:77,738,398...77,813,639
Ensembl chr11:64,235,251...64,304,811
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G
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Cat
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catalase
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decreases activity multiple interactions decreases expression
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EXP ISO
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Chloroquine results in decreased activity of CAT protein Chloroquine promotes the reaction [sunitinib results in increased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of CAT mRNA] Curcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein]; tetrahydrocurcumin inhibits the reaction [Chloroquine results in decreased activity of CAT protein] Chloroquine results in decreased expression of CAT protein
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CTD |
PMID:15526909 PMID:17076682 PMID:23607047 PMID:24751611 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G
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Ccl1
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C-C motif chemokine ligand 1
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL1 protein]
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CTD |
PMID:22341560 |
|
NCBI chr10:67,128,331...67,131,109
Ensembl chr10:67,128,331...67,131,159
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G
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Ccl11
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C-C motif chemokine ligand 11
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decreases secretion multiple interactions
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ISO
|
Chloroquine results in decreased secretion of CCL11 protein Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL11 protein]
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CTD |
PMID:22341560 PMID:29772762 |
|
NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G
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Ccl2
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C-C motif chemokine ligand 2
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increases expression multiple interactions decreases secretion
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ISO
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Chloroquine results in increased expression of CCL2 mRNA Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL2 protein] Chloroquine results in decreased secretion of CCL2 protein Acetylcysteine inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in decreased expression of MCP1 protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]; Tosylphenylalanyl Chloromethyl Ketone inhibits the reaction [Chloroquine results in increased expression of CCL2 mRNA]
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CTD |
PMID:15139008 PMID:22341560 PMID:29772762 PMID:35561756 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G
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Ccl25
|
C-C motif chemokine ligand 25
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL25 protein]
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CTD |
PMID:22341560 |
|
NCBI chr12:2,707,398...2,716,571
Ensembl chr12:2,707,398...2,716,554
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G
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Ccl5
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C-C motif chemokine ligand 5
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CCL5 protein]
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CTD |
PMID:22341560 |
|
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G
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Ccn1
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cellular communication network factor 1
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increases expression multiple interactions
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EXP ISO
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Chloroquine results in increased expression of CCN1 mRNA Chloroquine inhibits the reaction [pterostilbene inhibits the reaction [Ethanol results in increased expression of CCN1 protein]]
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CTD |
PMID:19393257 PMID:34405320 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G
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Cd274
|
CD274 molecule
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decreases expression
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ISO
|
Chloroquine results in decreased expression of CD274 protein
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CTD |
PMID:27692344 |
|
NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450
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G
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Cd34
|
CD34 molecule
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multiple interactions
|
ISO
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Chloroquine promotes the reaction [sunitinib results in decreased expression of CD34 protein]
|
CTD |
PMID:24751611 |
|
NCBI chr13:106,480,313...106,500,844
Ensembl chr13:106,480,043...106,499,832
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G
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Cdh1
|
cadherin 1
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multiple interactions
|
EXP
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Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in decreased expression of CDH1 protein]
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CTD |
PMID:30053495 |
|
NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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G
|
Cdh2
|
cadherin 2
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 mRNA]; Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CDH2 protein]
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CTD |
PMID:30053495 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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G
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Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases activity multiple interactions increases expression
|
ISO
|
Chloroquine results in increased activity of CDKN1A [Chloroquine co-treated with flavokawain B] results in decreased expression of CDKN1A protein; Chloroquine inhibits the reaction [Doxorubicin results in increased expression of CDKN1A protein] Chloroquine results in increased expression of CDKN1A protein
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CTD |
PMID:12243503 PMID:18089834 PMID:22927544 PMID:30025493 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
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G
|
Cdkn2a
|
cyclin-dependent kinase inhibitor 2A
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of CDKN2A protein]]
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CTD |
PMID:36792013 |
|
NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
|
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G
|
Cebpb
|
CCAAT/enhancer binding protein beta
|
multiple interactions increases expression
|
ISO
|
1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in decreased expression of ABCB1A protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form] 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CEBPB protein alternative form]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of CALR mRNA]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; [CEBPB protein alternative form results in increased susceptibility to Doxorubicin] promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; [Chloroquine co-treated with Bortezomib] promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; [Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CALR mRNA]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of and affects the localization of CALR protein]; CEBPB protein alternative form promotes the reaction [Chloroquine results in increased expression of CALR mRNA]; Chloroquine promotes the reaction [CEBPB protein alternative form binds to CALR promoter]; Doxorubicin promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of CEBPB protein alternative form]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of CEBPB protein alternative form]
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CTD |
PMID:30482226 |
|
NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
|
|
G
|
Chuk
|
component of inhibitor of nuclear factor kappa B kinase complex
|
decreases expression
|
ISO
|
Chloroquine results in decreased expression of CHUK protein
|
CTD |
PMID:26116531 |
|
NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
|
|
G
|
Cip2a
|
cellular inhibitor of PP2A
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [temsirolimus results in decreased expression of CIP2A protein]
|
CTD |
PMID:24493623 |
|
NCBI chr11:51,792,143...51,823,016
Ensembl chr11:51,795,024...51,822,938
|
|
G
|
Cldn1
|
claudin 1
|
increases expression
|
ISO
|
Chloroquine results in increased expression of CLDN1 mRNA
|
CTD |
PMID:25752684 |
|
NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724
|
|
G
|
Cldn2
|
claudin 2
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [caffeic acid phenethyl ester results in decreased expression of CLDN2 protein]
|
CTD |
PMID:29597147 |
|
NCBI chr X:108,248,383...108,258,847
Ensembl chr X:103,459,780...103,474,838
|
|
G
|
Clu
|
clusterin
|
affects localization
|
EXP
|
Chloroquine affects the localization of CLU protein
|
CTD |
PMID:8616629 |
|
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
|
|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [sodium arsenite results in increased expression of COL1A1 protein]
|
CTD |
PMID:38477077 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
|
|
G
|
Coq6
|
coenzyme Q6 monooxygenase
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of COQ6 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 6:104,007,814...104,019,888
Ensembl chr 6:104,007,872...104,024,657
|
|
G
|
Cox4i1
|
cytochrome c oxidase subunit 4i1
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [Triiodothyronine results in increased expression of COX4I1 protein]
|
CTD |
PMID:30209975 |
|
NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921
|
|
G
|
Cs
|
citrate synthase
|
multiple interactions
|
ISO
|
Chloroquine affects the reaction [triethylene glycol dimethacrylate affects the activity of CS protein]
|
CTD |
PMID:33684387 |
|
NCBI chr 7:758,074...791,421
Ensembl chr 7:758,345...791,421
|
|
G
|
Ctnnb1
|
catenin beta 1
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of CTNNB1 mRNA]
|
CTD |
PMID:30053495 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
|
|
G
|
Ctrb1
|
chymotrypsinogen B1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of CTRB1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr19:39,652,931...39,657,689
Ensembl chr19:39,652,933...39,657,688
|
|
G
|
Ctsa
|
cathepsin A
|
multiple interactions
|
ISO
|
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSA protein
|
CTD |
PMID:30821613 |
|
NCBI chr 3:153,569,106...153,574,983
Ensembl chr 3:153,568,381...153,576,215
|
|
G
|
Ctsb
|
cathepsin B
|
increases expression multiple interactions decreases activity
|
EXP ISO
|
Chloroquine results in increased expression of CTSB protein Chloroquine promotes the reaction [Arsenic results in increased activity of CTSB protein] Chloroquine results in decreased activity of CTSB protein [Chloroquine co-treated with dactolisib] affects the localization of CTSB protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSB protein; Chloroquine inhibits the reaction [Arsenic Trioxide results in increased activity of CTSB protein]
|
CTD |
PMID:2759144 PMID:23151917 PMID:30338810 PMID:30821613 PMID:36117518 |
|
NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
|
|
G
|
Ctsd
|
cathepsin D
|
affects localization multiple interactions increases expression
|
EXP ISO
|
Chloroquine affects the localization of CTSD protein [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of CTSD protein Chloroquine results in increased expression of CTSD protein
|
CTD |
PMID:2759144 PMID:7715800 PMID:30821613 |
|
NCBI chr 1:206,956,945...206,968,821
Ensembl chr 1:197,527,467...197,539,488
|
|
G
|
Ctsk
|
cathepsin K
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of CTSK mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of CTSK protein]
|
CTD |
PMID:35843418 |
|
NCBI chr 2:185,747,548...185,758,512
Ensembl chr 2:183,058,569...183,069,550
|
|
G
|
Ctsl
|
cathepsin L
|
increases expression
|
EXP
|
Chloroquine results in increased expression of CTSL protein
|
CTD |
PMID:2759144 |
|
NCBI chr17:770,104...776,266
Ensembl chr17:764,309...770,548
|
|
G
|
Cxcl10
|
C-X-C motif chemokine ligand 10
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [CpG ODN 2216 results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [gardiquimod results in increased expression of CXCL10 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of CXCL10 protein]
|
CTD |
PMID:26682054 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
|
|
G
|
Cxcl12
|
C-X-C motif chemokine ligand 12
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL12 protein]
|
CTD |
PMID:22341560 |
|
NCBI chr 4:152,060,781...152,073,628
Ensembl chr 4:150,388,325...150,401,168
|
|
G
|
Cxcl9
|
C-X-C motif chemokine ligand 9
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of CXCL9 protein]
|
CTD |
PMID:22341560 |
|
NCBI chr14:15,722,868...15,727,779
Ensembl chr14:15,722,908...15,728,435
|
|
G
|
Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of CYP11A1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
|
|
G
|
Cyp17a1
|
cytochrome P450, family 17, subfamily a, polypeptide 1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of CYP17A1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 1:255,476,861...255,484,547
Ensembl chr 1:245,535,462...245,541,573
|
|
G
|
Cyp1a2
|
cytochrome P450, family 1, subfamily a, polypeptide 2
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [CYP1A2 protein results in increased metabolism of Tacrine]
|
CTD |
PMID:7946932 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
|
|
G
|
Cyp2c79
|
cytochrome P450, family 2, subfamily c, polypeptide 79
|
affects metabolic processing multiple interactions increases metabolic processing
|
ISO
|
CYP2C8 polymorphism affects the metabolism of Chloroquine; CYP2C8 protein affects the metabolism of Chloroquine [CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine; Quercetin inhibits the reaction [[CYP2C8 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine]
|
CTD |
PMID:12756207 PMID:12920490 PMID:12967198 PMID:17286541 PMID:19560616 |
|
|
|
G
|
Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
|
affects metabolic processing decreases activity multiple interactions
|
ISO
|
CYP2D6 protein affects the metabolism of Chloroquine Chloroquine results in decreased activity of CYP2D6 protein [CYP2D6 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine
|
CTD |
PMID:12756207 PMID:12920490 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
|
|
G
|
Cyp3a2
|
cytochrome P450, family 3, subfamily a, polypeptide 2
|
multiple interactions affects metabolic processing decreases activity
|
ISO
|
[CYP3A4 protein results in increased metabolism of Chloroquine] which results in increased abundance of desethylchloroquine CYP3A4 protein affects the metabolism of Chloroquine Chloroquine results in decreased activity of CYP3A4 protein
|
CTD |
PMID:11124226 PMID:12756207 PMID:12920490 |
|
NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]
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CTD |
PMID:28275691 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
multiple interactions increases expression
|
EXP ISO
|
Chloroquine promotes the reaction [cadmium acetate results in increased expression of DDIT3 protein]; Chloroquine promotes the reaction [Cadmium results in increased expression of DDIT3 protein] Chloroquine results in increased expression of DDIT3 protein 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] affects the localization of CALR protein]; DDIT3 protein affects the reaction [[Chloroquine co-treated with Bortezomib] results in increased cleavage of CASP3 protein]; DDIT3 protein affects the reaction [Chloroquine affects the localization of CALR protein]; DDIT3 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of DDIT3 protein] 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein; [Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of DDIT3 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of DDIT3 protein]; Nitroprusside inhibits the reaction [Chloroquine results in increased expression of DDIT3 protein]
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CTD |
PMID:27658547 PMID:29870746 PMID:30482226 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
|
|
G
|
Ddx3x
|
DEAD-box helicase 3, X-linked
|
multiple interactions
|
ISO
|
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]
|
CTD |
PMID:30821613 |
|
NCBI chr X:12,152,346...12,165,983
Ensembl chr X:9,479,532...9,493,168
|
|
G
|
Eea1
|
early endosome antigen 1
|
affects localization
|
ISO
|
Chloroquine affects the localization of EEA1 protein
|
CTD |
PMID:29940786 |
|
NCBI chr 7:30,554,686...30,722,186
Ensembl chr 7:30,554,552...30,718,487
|
|
G
|
Egf
|
epidermal growth factor
|
multiple interactions
|
ISO EXP
|
Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein] Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of AKT1S1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]; Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein]; Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein]
|
CTD |
PMID:20332299 PMID:22689575 |
|
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
|
|
G
|
Egfr
|
epidermal growth factor receptor
|
multiple interactions decreases expression
|
ISO EXP
|
Chloroquine inhibits the reaction [EGF protein results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfide results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [sulindac sulfone results in decreased expression of EGFR protein]; Chloroquine inhibits the reaction [tephrosin results in increased degradation of EGFR protein] Chloroquine promotes the reaction [EGF protein results in increased expression of and results in increased phosphorylation of EGFR protein] Chloroquine results in decreased expression of EGFR protein
|
CTD |
PMID:20056314 PMID:20332299 PMID:22457794 PMID:22689575 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
|
|
G
|
Eif4a1
|
eukaryotic translation initiation factor 4A1
|
multiple interactions
|
ISO
|
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]
|
CTD |
PMID:30821613 |
|
NCBI chr10:54,384,345...54,389,855
Ensembl chr10:54,384,347...54,389,858
|
|
G
|
Eif4ebp1
|
eukaryotic translation initiation factor 4E binding protein 1
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of EIF4EBP1 protein]
|
CTD |
PMID:22689575 |
|
NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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|
G
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Eif4h
|
eukaryotic translation initiation factor 4H
|
multiple interactions
|
ISO
|
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein; Chloroquine inhibits the reaction [[quizartinib co-treated with spautin-1] results in increased degradation of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]
|
CTD |
PMID:30821613 |
|
NCBI chr12:27,719,527...27,736,350
Ensembl chr12:22,082,835...22,099,876
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|
G
|
Eno2
|
enolase 2
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Sirolimus results in increased expression of ENO2 protein]
|
CTD |
PMID:26676567 |
|
NCBI chr 4:159,258,371...159,267,220
Ensembl chr 4:157,572,088...157,580,980
|
|
G
|
Erbb2
|
erb-b2 receptor tyrosine kinase 2
|
decreases expression multiple interactions
|
ISO
|
Chloroquine results in decreased expression of ERBB2 protein Chloroquine inhibits the reaction [tephrosin results in increased degradation of ERBB2 protein]
|
CTD |
PMID:20056314 PMID:20332299 |
|
NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
|
|
G
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Erbb3
|
erb-b2 receptor tyrosine kinase 3
|
decreases expression
|
ISO
|
Chloroquine results in decreased expression of ERBB3 protein
|
CTD |
PMID:20332299 |
|
NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525
|
|
G
|
Ergic3
|
ERGIC and golgi 3
|
multiple interactions
|
ISO
|
ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]
|
CTD |
PMID:27588471 |
|
NCBI chr 3:144,525,059...144,534,813
Ensembl chr 3:144,525,092...144,534,813
|
|
G
|
Eva1a
|
eva-1 homolog A, regulator of programmed cell death
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in increased degradation of EVA1A protein]
|
CTD |
PMID:36078115 |
|
NCBI chr 4:114,593,773...114,643,011
Ensembl chr 4:114,593,341...114,643,011
|
|
G
|
Fads2
|
fatty acid desaturase 2
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of FADS2 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 1:216,132,277...216,172,190
Ensembl chr 1:206,708,783...206,748,789
|
|
G
|
Faslg
|
Fas ligand
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of FASL protein]
|
CTD |
PMID:22341560 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
|
|
G
|
Fbxo32
|
F-box protein 32
|
affects expression
|
EXP
|
Chloroquine affects the expression of FBXO32 mRNA
|
CTD |
PMID:19296457 |
|
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436
|
|
G
|
Fgf1
|
fibroblast growth factor 1
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in decreased expression of FGF1 mRNA]]
|
CTD |
PMID:31332898 |
|
NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
|
|
G
|
Fmn1
|
formin 1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of FMN1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 3:120,555,445...120,939,978
Ensembl chr 3:100,134,549...100,479,220
|
|
G
|
Foxp3
|
forkhead box P3
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of FOXP3 protein]
|
CTD |
PMID:31900833 |
|
NCBI chr X:17,580,380...17,601,181
Ensembl chr X:14,908,494...14,923,838
|
|
G
|
Fth1
|
ferritin heavy chain 1
|
multiple interactions increases expression
|
ISO EXP
|
Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of FTH1 mRNA]; Chloroquine inhibits the reaction [bisphenol A results in decreased expression of FTH1 protein]; Chloroquine inhibits the reaction [Diquat results in decreased expression of and results in increased degradation of FTH1 protein] Chloroquine promotes the reaction [erastin results in increased expression of FTH1 protein] Chloroquine results in increased expression of FTH1 mRNA
|
CTD |
PMID:30551460 PMID:32937103 PMID:37951334 PMID:38103660 PMID:38128689 PMID:38326183 More...
|
|
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
|
|
G
|
Ftl1
|
ferritin light chain 1
|
multiple interactions
|
ISO
|
Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]
|
CTD |
PMID:37951334 |
|
NCBI chr 1:105,072,858...105,074,705
Ensembl chr 1:95,936,387...95,939,725 Ensembl chr10:95,936,387...95,939,725 Ensembl chr 2:95,936,387...95,939,725
|
|
G
|
Fundc1
|
FUN14 domain containing 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Rotenone results in decreased expression of FUNDC1 protein]
|
CTD |
PMID:32001317 PMID:37156403 |
|
NCBI chr X:5,083,635...5,100,293
Ensembl chr X:5,083,617...5,100,284
|
|
G
|
Gabarapl2
|
GABA type A receptor associated protein like 2
|
increases expression
|
ISO
|
Chloroquine results in increased expression of GABARAPL2 protein
|
CTD |
PMID:36482696 |
|
NCBI chr19:39,910,572...39,921,408
Ensembl chr19:39,910,534...39,924,628
|
|
G
|
Gal3st1
|
galactose-3-O-sulfotransferase 1
|
multiple interactions
|
ISO
|
GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
|
CTD |
PMID:23880069 |
|
NCBI chr14:78,868,049...78,886,402
Ensembl chr14:78,870,793...78,886,388
|
|
G
|
Gja1
|
gap junction protein, alpha 1
|
multiple interactions
|
EXP ISO
|
Chloroquine inhibits the reaction [DDT results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Hexachlorocyclohexane results in increased degradation of GJA1 protein modified form]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in increased expression of GJA1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of GJA1 protein] Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]
|
CTD |
PMID:8824497 PMID:22150760 PMID:28713934 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
|
|
G
|
Gjb2
|
gap junction protein, beta 2
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of GJB2 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr15:35,375,977...35,393,817
Ensembl chr15:31,260,357...31,278,177
|
|
G
|
Glb1
|
galactosidase, beta 1
|
multiple interactions
|
ISO
|
[Chloroquine co-treated with flavokawain B] results in decreased expression of GLB1 protein Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of GLB1 protein]]
|
CTD |
PMID:30025493 PMID:36792013 |
|
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
|
|
G
|
Glp1r
|
glucagon-like peptide 1 receptor
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]
|
CTD |
PMID:22925809 |
|
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
|
|
G
|
Glul
|
glutamate-ammonia ligase
|
decreases expression
|
ISO
|
Chloroquine results in decreased expression of GLUL protein
|
CTD |
PMID:36482696 |
|
NCBI chr13:68,519,500...68,585,554
Ensembl chr13:66,025,630...66,035,108
|
|
G
|
Golga2
|
golgin A2
|
affects localization
|
ISO
|
Chloroquine affects the localization of GOLGA2 protein
|
CTD |
PMID:29940786 |
|
NCBI chr 3:35,981,783...36,002,023
Ensembl chr 3:15,584,039...15,604,279
|
|
G
|
Gpnmb
|
glycoprotein nmb
|
increases expression
|
EXP
|
Chloroquine results in increased expression of GPNMB mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 4:78,010,247...78,031,491
Ensembl chr 4:78,010,197...78,049,367
|
|
G
|
Gpr182
|
G protein-coupled receptor 182
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of GPR182 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 7:63,585,997...63,589,088
Ensembl chr 7:63,578,750...63,589,210
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [coenzyme Q10 inhibits the reaction [Acetaminophen results in increased activity of GPT protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased activity of GPT protein]; Chloroquine promotes the reaction [Acetaminophen results in increased activity of GPT protein] [Chloroquine co-treated with Clozapine] results in increased secretion of GPT protein
|
CTD |
PMID:26498332 PMID:33271250 PMID:36482696 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Gpx4
|
glutathione peroxidase 4
|
decreases expression multiple interactions
|
ISO
|
Chloroquine results in decreased expression of GPX4 mRNA Chloroquine inhibits the reaction [Antimony results in decreased expression of GPX4 protein]; Chloroquine inhibits the reaction [bisphenol A results in decreased expression of GPX4 protein]; Chloroquine inhibits the reaction [Particulate Matter results in decreased expression of GPX4 protein] Chloroquine inhibits the reaction [Cisplatin results in decreased expression of GPX4 protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GPX4 mRNA]
|
CTD |
PMID:23607047 PMID:34302894 PMID:36700298 PMID:38097005 PMID:38103660 PMID:38326183 More...
|
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
|
|
G
|
Grin2b
|
glutamate ionotropic receptor NMDA type subunit 2B
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of GRIN2B]
|
CTD |
PMID:26327526 |
|
NCBI chr 4:170,297,811...170,775,420
Ensembl chr 4:168,599,546...169,042,279
|
|
G
|
Gsdmd
|
gasdermin D
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of and results in increased cleavage of GSDMD protein]
|
CTD |
PMID:34920032 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
decreases activity decreases expression multiple interactions
|
ISO
|
Chloroquine results in decreased activity of GSR protein Chloroquine results in decreased expression of GSR mRNA Quercetin inhibits the reaction [Chloroquine results in decreased activity of GSR protein]; Quercetin inhibits the reaction [Chloroquine results in decreased expression of GSR mRNA]
|
CTD |
PMID:23607047 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
|
|
G
|
Hbg1
|
hemoglobin subunit gamma 1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of HBG1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 1:158,271,871...158,273,426
Ensembl chr 1:158,271,873...158,273,425
|
|
G
|
Hdac6
|
histone deacetylase 6
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in increased expression of HDAC6 protein]]
|
CTD |
PMID:35104487 |
|
NCBI chr X:17,222,538...17,244,373
Ensembl chr X:14,551,044...14,572,441
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Butyric Acid results in decreased expression of HIF1A protein]
|
CTD |
PMID:39241941 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
|
|
G
|
Hk2
|
hexokinase 2
|
multiple interactions
|
ISO
|
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]
|
CTD |
PMID:30821613 |
|
NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530
|
|
G
|
Hmbs
|
hydroxymethylbilane synthase
|
increases response to substance
|
ISO
|
HMBS mutant form results in increased susceptibility to Chloroquine
|
CTD |
PMID:8772850 |
|
NCBI chr 8:44,673,554...44,680,950
Ensembl chr 8:44,673,554...44,680,957
|
|
G
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Hoxa10
|
homeobox A10
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HOXA10 mRNA]; Chloroquine inhibits the reaction [Benzo(a)pyrene results in decreased expression of HOXA10 protein]
|
CTD |
PMID:39454710 |
|
NCBI chr 4:81,331,591...81,340,878
Ensembl chr 4:81,331,591...81,340,919
|
|
G
|
Hspa1b
|
heat shock protein family A (Hsp70) member 1B
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]
|
CTD |
PMID:17046822 |
|
NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
multiple interactions
|
EXP
|
Chloroquine promotes the reaction [cadmium acetate results in increased expression of HSPA5 protein]
|
CTD |
PMID:29870746 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
|
|
G
|
Hspa8
|
heat shock protein family A (Hsp70) member 8
|
multiple interactions
|
ISO
|
[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HSPA8 protein alternative form Chloroquine inhibits the reaction [Thymol inhibits the reaction [Ethanol results in decreased expression of HSPA8 protein]]
|
CTD |
PMID:30821613 PMID:36535314 |
|
NCBI chr 8:50,080,514...50,084,376
Ensembl chr 8:41,183,264...41,187,259
|
|
G
|
Icam1
|
intercellular adhesion molecule 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]
|
CTD |
PMID:24145604 |
|
NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
|
|
G
|
Ifnb1
|
interferon beta 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]
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CTD |
PMID:28134560 |
|
NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
[Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IFNG mRNA [Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IFNG protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of IFNG protein]]
|
CTD |
PMID:22341560 PMID:29594315 PMID:30482226 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
|
|
G
|
Igf2bp3
|
insulin-like growth factor 2 mRNA binding protein 3
|
multiple interactions
|
ISO
|
[Chloroquine co-treated with Berberine] results in decreased expression of IGF2BP3 protein
|
CTD |
PMID:36822301 |
|
NCBI chr 4:78,060,494...78,195,007
Ensembl chr 4:78,060,494...78,194,865
|
|
G
|
Ikbkb
|
inhibitor of nuclear factor kappa B kinase subunit beta
|
decreases expression
|
ISO
|
Chloroquine results in decreased expression of IKBKB protein
|
CTD |
PMID:26116531 |
|
NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250
|
|
G
|
Ikbkg
|
inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
|
decreases expression
|
ISO
|
Chloroquine results in decreased expression of IKBKG protein
|
CTD |
PMID:26116531 |
|
NCBI chr X:157,358,279...157,397,563
Ensembl chr X:152,216,596...152,239,499
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL10 protein]
|
CTD |
PMID:22341560 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
|
|
G
|
Il13
|
interleukin 13
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL13 protein]
|
CTD |
PMID:22341560 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:37,790,130...37,792,737
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL17A protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL17A protein]
|
CTD |
PMID:22341560 PMID:36002070 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
|
|
G
|
Il18
|
interleukin 18
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL18 protein]
|
CTD |
PMID:34920032 |
|
NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
|
|
G
|
Il1a
|
interleukin 1 alpha
|
increases expression multiple interactions
|
ISO
|
Chloroquine results in increased expression of IL1A Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1A protein]
|
CTD |
PMID:15139008 PMID:22341560 |
|
NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
|
|
G
|
Il1b
|
interleukin 1 beta
|
increases expression decreases expression multiple interactions
|
ISO
|
Chloroquine results in increased expression of IL1B Chloroquine results in decreased expression of IL1B mRNA Chloroquine inhibits the reaction [Imiquimod results in increased expression of IL1B protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL1B protein] Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL1B mRNA]]; Chloroquine inhibits the reaction [Uric Acid results in increased secretion of IL1B protein]; Chloroquine promotes the reaction [[lipopolysaccharide, Escherichia coli O111 B4 co-treated with sodium arsenite] results in increased expression of IL1B protein]
|
CTD |
PMID:15139008 PMID:21051542 PMID:22341560 PMID:26498332 PMID:29594315 PMID:31648047 PMID:34920032 PMID:36002070 More...
|
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G
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Il2
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interleukin 2
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decreases expression multiple interactions
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ISO
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Chloroquine results in decreased expression of IL2 mRNA; Chloroquine results in decreased expression of IL2 protein Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL2 protein] [Chloroquine co-treated with Ionomycin co-treated with Tetradecanoylphorbol Acetate] results in decreased expression of IL2 mRNA
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CTD |
PMID:7554381 PMID:22341560 PMID:29594315 |
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NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
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G
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Il3
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interleukin 3
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL3 protein]
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CTD |
PMID:22341560 |
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NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066
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G
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Il4
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interleukin 4
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL4 protein]
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CTD |
PMID:22341560 |
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NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G
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Il6
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interleukin 6
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decreases expression multiple interactions decreases secretion increases expression
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ISO EXP
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Chloroquine results in decreased expression of IL6 protein Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased expression of IL6 mRNA]] Chloroquine results in decreased secretion of IL6 protein Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of IL6 protein]] [Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Bortezomib inhibits the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL6 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of IL6 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]] Chloroquine results in increased expression of IL6
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CTD |
PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 PMID:26498332 PMID:28134560 PMID:29772762 PMID:31332898 PMID:31648047 More...
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G
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Irf3
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interferon regulatory factor 3
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of IRF3 protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IRF3 protein]; Chloroquine inhibits the reaction [Poly I-C results in increased phosphorylation of IRF3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]
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CTD |
PMID:22341560 PMID:25780039 PMID:28134560 |
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NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
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G
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Itgam
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integrin subunit alpha M
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multiple interactions
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ISO
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[benzyloxycarbonyl-valyl-alanyl-aspartic acid analog co-treated with Chloroquine] inhibits the reaction [Tretinoin affects the localization of ITGAM protein]; Chloroquine inhibits the reaction [Tretinoin affects the localization of ITGAM protein]
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CTD |
PMID:29743969 |
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NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
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G
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Jak2
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Janus kinase 2
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decreases phosphorylation
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ISO
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chloroquine co-treated with anlotinib decreases phosphorylation of JAK2 protein in lung epithelium
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RGD |
PMID:30755242 |
RGD:149735343 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G
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Lamb1
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laminin subunit beta 1
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [LAMB1 protein affects the localization of GJA1 protein]
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CTD |
PMID:22150760 |
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NCBI chr 6:47,835,492...47,902,585
Ensembl chr 6:47,835,525...47,902,585
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G
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Lamp2
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lysosomal-associated membrane protein 2
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multiple interactions
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ISO
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[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein; [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein alternative form; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of DDX3X protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4A1 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of EIF4H protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of HK2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of LAMP2 protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]
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CTD |
PMID:30821613 |
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NCBI chr X:122,038,734...122,087,745
Ensembl chr X:117,057,606...117,260,522
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G
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Lat2
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linker for activation of T cells family, member 2
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increases response to substance
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ISO
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LAT2 protein results in increased susceptibility to Chloroquine
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CTD |
PMID:32587277 |
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NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288
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G
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Lcn2
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lipocalin 2
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increases expression
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EXP
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Chloroquine results in increased expression of LCN2 mRNA
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CTD |
PMID:19393257 |
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NCBI chr 3:15,680,688...15,684,033
Ensembl chr 3:15,680,687...15,684,095
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G
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Ldha
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lactate dehydrogenase A
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [ginsenoside Rb1 inhibits the reaction [alpha-Chlorohydrin results in increased secretion of LDHA protein]]
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CTD |
PMID:38373586 |
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NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
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G
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Ldlr
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low density lipoprotein receptor
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multiple interactions
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ISO
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Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]
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CTD |
PMID:30950489 |
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NCBI chr 8:28,546,191...28,569,075
Ensembl chr 8:20,270,041...20,294,580
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G
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Lep
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leptin
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of LEP protein]
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CTD |
PMID:22341560 |
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NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G
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Lepr
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leptin receptor
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increases expression
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ISO
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Chloroquine results in increased expression of LEPR protein
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CTD |
PMID:31199479 |
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NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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G
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Ltb
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lymphotoxin beta
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increases expression
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ISO
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Chloroquine results in increased expression of LTB
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CTD |
PMID:15139008 |
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NCBI chr20:3,627,536...3,629,381
Ensembl chr20:3,627,537...3,629,381
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G
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M6pr
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mannose-6-phosphate receptor, cation dependent
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affects expression affects localization
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EXP ISO
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Chloroquine affects the expression of M6PR mRNA Chloroquine affects the localization of M6PR protein
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CTD |
PMID:15712280 PMID:29940786 |
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NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
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G
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Map1lc3a
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microtubule-associated protein 1 light chain 3 alpha
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increases expression multiple interactions
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ISO EXP
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Chloroquine results in increased expression of MAP1LC3A protein; Chloroquine results in increased expression of MAP1LC3A protein modified form Chloroquine inhibits the reaction [doramectin results in decreased expression of and results in increased lipidation of MAP1LC3A protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of MAP1LC3A protein] Chloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3A protein] Chloroquine inhibits the reaction [hydroquinone results in increased degradation of MAP1LC3A protein]
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CTD |
PMID:30280407 PMID:30871063 PMID:35137919 PMID:35302183 PMID:35843418 |
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NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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G
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Map1lc3b
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microtubule-associated protein 1 light chain 3 beta
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increases expression decreases degradation increases lipidation multiple interactions affects localization increases cleavage
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EXP ISO
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Chloroquine results in increased expression of MAP1LC3B mRNA; Chloroquine results in increased expression of MAP1LC3B protein; Chloroquine results in increased expression of MAP1LC3B protein modified form Chloroquine results in decreased degradation of MAP1LC3B protein modified form Chloroquine results in increased lipidation of MAP1LC3B protein Chloroquine inhibits the reaction [dehydroandrographolide inhibits the reaction [Doxorubicin results in increased lipidation of MAP1LC3B protein]]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [Cisplatin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [erastin results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [trichostatin A results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Vorinostat results in increased expression of MAP1LC3B protein modified form] Chloroquine affects the localization of MAP1LC3B protein Chloroquine results in increased cleavage of MAP1LC3B protein [Ethanol co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; Chloroquine affects the reaction [Cadmium Chloride results in increased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [dibromoacetonitrile results in increased expression of and results in increased localization of MAP1LC3B protein]; Chloroquine results in increased lipidation of and results in increased localization of MAP1LC3B protein; MJN110 affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein] [4-nitrochalcone co-treated with Chloroquine] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with aumolertinib] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with Clozapine] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with flavokawain B] results in increased expression of MAP1LC3B protein modified form; [Chloroquine co-treated with Oxygen deficiency] results in increased lipidation of MAP1LC3B protein; [Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; bafilomycin A1 inhibits the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [dorsomorphin results in increased lipidation of MAP1LC3B protein]; Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [cordycepin results in increased expression of MAP1LC3B mRNA]; Chloroquine inhibits the reaction [ovatodiolide results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [1-Methyl-4-phenylpyridinium results in increased lipidation of and results in increased localization of MAP1LC3B protein]; Chloroquine promotes the reaction [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline affects the localization of MAP1LC3B protein]; Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [[Simvastatin co-treated with Metformin] results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [ABBV-744 results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [ABBV-744 results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [bisphenol A results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [CYP7A1 protein results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [Ethanol results in increased expression of MAP1LC3B protein]; Chloroquine promotes the reaction [flavokawain B results in increased expression of MAP1LC3B protein modified form]; Chloroquine promotes the reaction [fosbretabulin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [hydroquinone results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [olaparib promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; Chloroquine promotes the reaction [palmitoyl glycerol results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [pectolinarigenin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [Rifampin results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [SC-66 compound results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [sepantronium results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [sodium arsenite results in increased lipidation of MAP1LC3B protein]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein; Chloroquine results in increased lipidation of and results in increased cleavage of MAP1LC3B protein; cryptotanshinone promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein]; CYP7A1 mRNA promotes the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; GAL3ST1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Hydrogen Peroxide inhibits the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; olaparib promotes the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; olaparib promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; Paraquat inhibits the reaction [Chloroquine results in increased expression of MAP1LC3B protein modified form]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]; pectolinarigenin promotes the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein]
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CTD |
PMID:17643062 PMID:23880069 PMID:24095927 PMID:24145604 PMID:24161432 PMID:24492484 PMID:25412314 PMID:25884947 PMID:26409479 PMID:28275691 PMID:28600121 PMID:28722353 PMID:28906492 PMID:29248574 PMID:29476062 PMID:30025493 PMID:30208301 PMID:30237538 PMID:30301768 PMID:30338810 PMID:31310755 PMID:31586597 PMID:31648047 PMID:31837377 PMID:31862506 PMID:31900833 PMID:32861759 PMID:32937103 PMID:33203845 PMID:33609687 PMID:34219533 PMID:34826546 PMID:35104487 PMID:35843418 PMID:36070022 PMID:36078115 PMID:36299321 PMID:36482696 PMID:36958258 PMID:37148176 PMID:37393350 PMID:37466199 PMID:37741534 PMID:37769529 PMID:37939893 PMID:38000454 PMID:38040083 PMID:38065397 PMID:38326183 PMID:38964637 More...
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NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G
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Map2
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microtubule-associated protein 2
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multiple interactions
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EXP
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Chloroquine inhibits the reaction [Sirolimus results in increased expression of MAP2 protein]
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CTD |
PMID:26676567 |
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NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809
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G
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Mapk1
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mitogen activated protein kinase 1
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increases phosphorylation multiple interactions
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ISO
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Chloroquine results in increased phosphorylation of MAPK1 protein Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]
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CTD |
PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 |
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G
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Mapk14
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mitogen activated protein kinase 14
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [hydroquinone results in increased phosphorylation of MAPK14 protein]
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CTD |
PMID:35302183 |
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NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
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G
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Mapk3
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mitogen activated protein kinase 3
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multiple interactions increases phosphorylation
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]] Chloroquine results in increased phosphorylation of MAPK3 protein
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CTD |
PMID:18055026 PMID:22341560 PMID:28134560 PMID:31310755 |
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
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Mapk8
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mitogen-activated protein kinase 8
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK8 protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]] Chloroquine inhibits the reaction [Rifampin inhibits the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]]; Chloroquine promotes the reaction [Rotenone results in increased phosphorylation of MAPK8 protein]
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CTD |
PMID:22341560 PMID:28134560 PMID:31648047 |
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NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G
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Mapt
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microtubule-associated protein tau
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affects expression multiple interactions
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EXP ISO
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Chloroquine affects the expression of MAPT mRNA; Chloroquine affects the expression of MAPT protein Chloroquine inhibits the reaction [Sertraline results in decreased expression of and results in decreased cleavage of MAPT protein] Chloroquine affects the localization of and affects the degradation of MAPT protein
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CTD |
PMID:9690670 PMID:33124469 |
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NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
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G
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Mcl1
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MCL1 apoptosis regulator, BCL2 family member
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multiple interactions
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ISO
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Chloroquine promotes the reaction [usnic acid results in decreased expression of MCL1 protein]
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CTD |
PMID:25078063 |
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NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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G
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Mir155
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microRNA 155
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multiple interactions
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ISO
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[Carboplatin co-treated with Chloroquine] results in increased expression of MIR155 mRNA
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CTD |
PMID:27692344 |
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NCBI chr11:37,261,114...37,261,178
Ensembl chr11:23,774,654...23,774,718
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G
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Mir224
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microRNA 224
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ISO
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inhibits the reaction [Amiodarone decreased expression of miR224 in a human hepatoma cell line]
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RGD |
PMID:23913306 |
RGD:18182923 |
NCBI chr X:150,065,088...150,065,169
Ensembl chr X:150,065,088...150,065,169
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G
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Mki67
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marker of proliferation Ki-67
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multiple interactions
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ISO
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[Chloroquine co-treated with flavokawain B] results in decreased expression of MKI67 protein [Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein; CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]; Doxorubicin promotes the reaction [CEBPB protein alternative form promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of MKI67 protein]]
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CTD |
PMID:30025493 PMID:30482226 |
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NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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G
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Mmp13
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matrix metallopeptidase 13
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multiple interactions increases expression
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ISO
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Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]] Chloroquine results in increased expression of MMP13 mRNA; Chloroquine results in increased expression of MMP13 protein Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased expression of MMP13 mRNA]; Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of MMP13 protein]
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CTD |
PMID:23331101 PMID:24273604 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G
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Mmp2
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matrix metallopeptidase 2
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decreases expression multiple interactions
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ISO
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Chloroquine results in decreased expression of MMP2 mRNA; Chloroquine results in decreased expression of MMP2 protein Chloroquine inhibits the reaction [cordycepin results in decreased activity of MMP2 protein]; Chloroquine inhibits the reaction [cordycepin results in decreased expression of MMP2 mRNA]; Sirolimus inhibits the reaction [Chloroquine results in decreased expression of MMP2 protein]
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CTD |
PMID:24273604 PMID:34278709 PMID:36299321 |
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NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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G
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Mmp9
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matrix metallopeptidase 9
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multiple interactions increases expression decreases expression
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ISO
|
Chloroquine inhibits the reaction [Artesunate results in decreased expression of MMP9 mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Oxygen deficiency inhibits the reaction [Chloroquine results in decreased expression of MMP9 mRNA] Chloroquine results in increased expression of MMP9 mRNA Chloroquine results in decreased expression of MMP9 mRNA; Chloroquine results in decreased expression of MMP9 protein
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CTD |
PMID:24145604 PMID:24273604 PMID:30551460 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G
|
Mterf3
|
mitochondrial transcription termination factor 3
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of MTERF3 protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of MTERF3 protein]
|
CTD |
PMID:35904214 |
|
NCBI chr 7:63,826,418...63,844,747
Ensembl chr 7:63,826,427...63,844,658
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G
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Mtor
|
mechanistic target of rapamycin kinase
|
multiple interactions decreases phosphorylation increases expression
|
ISO
|
Chloroquine inhibits the reaction [formosanin C results in decreased phosphorylation of MTOR protein] Chloroquine results in decreased phosphorylation of MTOR protein Chloroquine results in increased expression of MTOR protein
|
CTD |
PMID:25884947 PMID:27180204 PMID:31310755 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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|
G
|
Mttp
|
microsomal triglyceride transfer protein
|
multiple interactions increases expression
|
ISO
|
[benzyloxycarbonylleucyl-leucyl-leucine aldehyde co-treated with Chloroquine] results in increased expression of MTTP protein Chloroquine results in increased expression of MTTP protein
|
CTD |
PMID:34516972 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
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G
|
Muc1
|
mucin 1, cell surface associated
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [MUC1 affects the expression of EGFR protein]
|
CTD |
PMID:22457794 |
|
NCBI chr 2:174,635,989...174,640,738
Ensembl chr 2:174,635,995...174,640,733
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G
|
Myd88
|
MYD88, innate immune signal transduction adaptor
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of MYD88 mRNA]
|
CTD |
PMID:22341560 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
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|
G
|
Myom2
|
myomesin 2
|
increases expression
|
EXP
|
Chloroquine results in increased expression of MYOM2 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr16:74,520,148...74,592,658
Ensembl chr16:74,520,157...74,592,772
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|
G
|
Nacc1
|
nucleus accumbens associated 1
|
multiple interactions
|
ISO
|
Chloroquine affects the reaction [NACC1 affects the susceptibility to Cisplatin]
|
CTD |
PMID:21743489 |
|
NCBI chr19:23,468,688...23,486,528
Ensembl chr19:23,468,419...23,486,528
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G
|
Ncoa4
|
nuclear receptor coactivator 4
|
multiple interactions increases expression
|
ISO EXP
|
Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of NCOA4 mRNA]; Chloroquine inhibits the reaction [Particulate Matter results in increased expression of NCOA4 protein] Chloroquine inhibits the reaction [erastin results in decreased expression of NCOA4 protein] Chloroquine results in increased expression of NCOA4 mRNA; Chloroquine results in increased expression of NCOA4 protein
|
CTD |
PMID:30551460 PMID:32937103 PMID:36482696 PMID:36700298 PMID:37951334 |
|
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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|
G
|
Ndrg1
|
N-myc downstream regulated 1
|
multiple interactions
|
ISO
|
Chloroquine affects the reaction [NDRG1 protein affects the lipidation of MAP1LC3B protein]; Chloroquine inhibits the reaction [Cycloheximide results in decreased expression of NDRG1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased expression of NDRG1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of CASP3 protein]]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of CASP3 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]; NDRG1 protein affects the susceptibility to [fosbretabulin co-treated with Chloroquine]
|
CTD |
PMID:28906492 |
|
NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
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|
G
|
Nfkb1
|
nuclear factor kappa B subunit 1
|
decreases expression multiple interactions
|
ISO
|
Chloroquine results in decreased expression of NFKB1 protein Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased activity of NFKB1 protein]
|
CTD |
PMID:22341560 PMID:26116531 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]] [quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein; Chloroquine inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; LAMP2 protein alternative form affects the reaction [[quizartinib co-treated with spautin-1 co-treated with Chloroquine] results in increased transport of and affects the localization of NFKBIA protein]
|
CTD |
PMID:24085292 PMID:28134560 PMID:30821613 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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|
G
|
Nlrp3
|
NLR family, pyrin domain containing 3
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [PPARG protein inhibits the reaction [Dexamethasone results in increased expression of NLRP3 protein]]
|
CTD |
PMID:38286393 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
|
|
G
|
Nod2
|
nucleotide-binding oligomerization domain containing 2
|
multiple interactions
|
ISO
|
NOD2 protein affects the reaction [Chloroquine results in increased lipidation of MAP1LC3B protein]
|
CTD |
PMID:23880069 |
|
NCBI chr19:34,555,832...34,596,281
Ensembl chr19:18,382,439...18,417,177
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|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [sunitinib results in increased expression of NOS2 protein]
|
CTD |
PMID:24751611 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Notch1
|
notch receptor 1
|
multiple interactions
|
ISO
|
[Fluorouracil co-treated with Chloroquine] results in increased expression of NOTCH1 protein
|
CTD |
PMID:29917191 |
|
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
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|
G
|
Nppc
|
natriuretic peptide C
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of NPPC mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 9:87,320,051...87,324,251
Ensembl chr 9:87,320,051...87,324,251
|
|
G
|
Nqo2
|
N-ribosyldihydronicotinamide:quinone dehydrogenase 2
|
multiple interactions
|
ISO
|
Chloroquine binds to and results in decreased activity of NQO2 protein
|
CTD |
PMID:15078100 |
|
NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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|
G
|
Nr0b2
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nuclear receptor subfamily 0, group B, member 2
|
decreases expression
|
ISO
|
Chloroquine results in decreased expression of NR0B2 mRNA
|
CTD |
PMID:24189133 |
|
NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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|
G
|
Nr4a2
|
nuclear receptor subfamily 4, group A, member 2
|
multiple interactions
|
ISO
|
Chloroquine binds to and results in increased activity of NR4A2 protein
|
CTD |
PMID:31175960 |
|
NCBI chr 3:62,098,739...62,115,926
Ensembl chr 3:41,689,851...41,697,877
|
|
G
|
Ocln
|
occludin
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increases expression
|
ISO
|
Chloroquine results in increased expression of OCLN mRNA
|
CTD |
PMID:25752684 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
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|
G
|
Optn
|
optineurin
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein]
|
CTD |
PMID:25884947 |
|
NCBI chr17:73,209,572...73,260,251
Ensembl chr17:73,209,575...73,260,251
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|
G
|
Osgin1
|
oxidative stress induced growth inhibitor 1
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of OSGIN1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions increases cleavage
|
EXP ISO
|
Chloroquine promotes the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [Methamphetamine results in increased cleavage of PARP1 protein] Chloroquine results in increased cleavage of PARP1 protein [Chloroquine co-treated with 3-methyladenine] results in increased cleavage of PARP1 protein; [Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Arsenic Trioxide promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [betulin results in increased cleavage of PARP1 protein]; Chloroquine inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [SC-66 compound results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased activity of PARP1 protein]; NDRG1 protein affects the reaction [Chloroquine promotes the reaction [fosbretabulin results in increased cleavage of PARP1 protein]]; NDRG1 protein affects the reaction [Chloroquine results in increased cleavage of PARP1 protein]; PARP1 protein affects the reaction [Chloroquine promotes the reaction [[ferric ammonium citrate results in increased abundance of Iron] which results in increased lipidation of MAP1LC3B protein]]
|
CTD |
PMID:27658547 PMID:28906492 PMID:29111403 PMID:30025493 PMID:30338810 PMID:30985881 PMID:31310755 PMID:32190974 PMID:34374793 PMID:34826546 PMID:35022897 PMID:36958258 PMID:37741534 More...
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|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Pcna
|
proliferating cell nuclear antigen
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Imiquimod results in increased expression of PCNA protein]
|
CTD |
PMID:36002070 |
|
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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|
G
|
Pink1
|
PTEN induced kinase 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PINK1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PINK1 protein]]
|
CTD |
PMID:33271250 |
|
NCBI chr 5:155,813,838...155,825,950
Ensembl chr 5:150,530,523...150,542,635
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|
G
|
Plin3
|
perilipin 3
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 mRNA]; Chloroquine inhibits the reaction [CpG ODN 1826 results in increased expression of PLIN3 protein]
|
CTD |
PMID:20628022 |
|
NCBI chr 9:1,111,178...1,123,057
Ensembl chr 9:1,102,366...1,123,147
|
|
G
|
Pmaip1
|
phorbol-12-myristate-13-acetate-induced protein 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of PMAIP1 protein]
|
CTD |
PMID:35561756 |
|
NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429
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|
G
|
Pomc
|
proopiomelanocortin
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [POMC protein modified form results in increased chemical synthesis of Adrenal Cortex Hormones]
|
CTD |
PMID:2993719 |
|
NCBI chr 6:32,659,137...32,665,175
Ensembl chr 6:26,939,837...26,945,664
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [PPARG protein inhibits the reaction [Dexamethasone results in increased expression of NLRP3 protein]]
|
CTD |
PMID:38286393 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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|
G
|
Ppp2ca
|
protein phosphatase 2 catalytic subunit alpha
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [hydroquinone results in increased expression of PPP2CA protein]
|
CTD |
PMID:35302183 |
|
NCBI chr10:36,856,534...36,878,789
Ensembl chr10:36,358,101...36,377,862
|
|
G
|
Ppt1
|
palmitoyl-protein thioesterase 1
|
multiple interactions
|
ISO
|
Chloroquine analog binds to and results in decreased activity of PPT1 protein; Chloroquine binds to and results in decreased activity of PPT1 protein
|
CTD |
PMID:30442709 |
|
NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:135,121,163...135,142,048
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|
G
|
Prkd2
|
protein kinase D2
|
multiple interactions
|
ISO
|
Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTH1 protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of FTL protein]; Chloroquine affects the reaction [[PRKD2 protein affects the susceptibility to erastin] which affects the expression of NCOA4 protein]
|
CTD |
PMID:37951334 |
|
NCBI chr 1:86,640,095...86,670,476
Ensembl chr 1:77,513,986...77,542,376
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G
|
Prkn
|
parkin RBR E3 ubiquitin protein ligase
|
multiple interactions
|
ISO EXP
|
Chloroquine inhibits the reaction [Acetaminophen results in increased expression of PRKN protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in increased expression of PRKN protein]] Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of PRKN protein]]
|
CTD |
PMID:33271250 PMID:35104487 |
|
NCBI chr 1:51,236,410...52,430,242
Ensembl chr 1:48,690,556...49,882,555
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|
G
|
Prl
|
prolactin
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Benzo(a)pyrene results in decreased expression of PRL mRNA]
|
CTD |
PMID:39454710 |
|
NCBI chr17:38,287,355...38,298,234
Ensembl chr17:37,860,007...37,870,062
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|
G
|
Prlr
|
prolactin receptor
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of PRLR mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 2:60,861,391...61,051,883
Ensembl chr 2:59,134,588...59,324,718
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|
G
|
Pten
|
phosphatase and tensin homolog
|
increases expression
|
ISO
|
Chloroquine results in increased expression of PTEN mRNA
|
CTD |
PMID:31310755 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
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|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [bisphenol A results in increased expression of PTGS2 protein]; Chloroquine inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]
|
CTD |
PMID:24145604 PMID:36700298 PMID:38103660 PMID:38326183 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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|
G
|
Rbpj
|
recombination signal binding protein for immunoglobulin kappa J region
|
increases expression
|
ISO
|
Chloroquine results in increased expression of RBPJ protein
|
CTD |
PMID:22302987 |
|
NCBI chr14:61,551,366...61,736,220
Ensembl chr14:57,338,507...57,523,353
|
|
G
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Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions decreases expression increases activity
|
ISO EXP
|
Acetylcysteine inhibits the reaction [Chloroquine results in increased activity of RELA protein]; diphenyliodonium inhibits the reaction [Chloroquine results in increased activity of RELA protein] Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of RELA protein] Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of RELA protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]] Chloroquine results in decreased expression of RELA protein
|
CTD |
PMID:15139008 PMID:24990399 PMID:26116531 PMID:28134560 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G
|
Rheb
|
Ras homolog, mTORC1 binding
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [EGF protein results in increased expression of RHEB protein]
|
CTD |
PMID:22689575 |
|
NCBI chr 4:11,012,173...11,053,860
Ensembl chr 4:10,279,370...10,320,160
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|
G
|
Rhob
|
ras homolog family member B
|
increases expression
|
ISO
|
Chloroquine results in increased expression of RHOB protein
|
CTD |
PMID:36482696 |
|
NCBI chr 6:31,363,752...31,365,926
Ensembl chr 6:31,363,548...31,366,108
|
|
G
|
Rps6kb1
|
ribosomal protein S6 kinase B1
|
decreases phosphorylation multiple interactions increases expression
|
ISO EXP
|
Chloroquine results in decreased phosphorylation of RPS6KB1 protein Chloroquine inhibits the reaction [EGF protein results in increased phosphorylation of RPS6KB1 protein] Chloroquine results in increased expression of RPS6KB1 protein modified form
|
CTD |
PMID:22689575 PMID:25884947 PMID:31310755 |
|
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
|
|
G
|
Runx2
|
RUNX family transcription factor 2
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [[Dexamethasone co-treated with ascorbate-2-phosphate co-treated with beta-glycerophosphoric acid] results in increased expression of RUNX2 mRNA]
|
CTD |
PMID:23111315 |
|
NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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|
G
|
Scarb1
|
scavenger receptor class B, member 1
|
decreases expression multiple interactions
|
EXP ISO
|
Chloroquine results in decreased expression of SCARB1 mRNA [Chloroquine co-treated with Lovastatin] inhibits the reaction [SCARB1 protein results in increased abundance of Progesterone]
|
CTD |
PMID:19393257 PMID:20404351 |
|
NCBI chr12:36,957,302...37,023,982
Ensembl chr12:31,296,156...31,362,647
|
|
G
|
Sccpdh
|
saccharopine dehydrogenase (putative)
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of SCCPDH mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr13:91,400,120...91,421,875
Ensembl chr13:91,400,190...91,422,222
|
|
G
|
Scd
|
stearoyl-CoA desaturase
|
decreases expression
|
EXP
|
Chloroquine results in decreased expression of SCD1 mRNA
|
CTD |
PMID:19393257 |
|
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
|
|
G
|
Senp6
|
SUMO specific peptidase 6
|
multiple interactions
|
ISO
|
[Lipopolysaccharides co-treated with Chloroquine] results in increased expression of SENP6 protein
|
CTD |
PMID:26807181 |
|
NCBI chr 8:80,988,675...81,071,606
Ensembl chr 8:80,989,052...81,067,170
|
|
G
|
Serpina3n
|
serpin family A member 3N
|
affects localization
|
EXP
|
Chloroquine affects the localization of SERPINA3 protein
|
CTD |
PMID:8616629 |
|
NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433
|
|
G
|
Serpine1
|
serpin family E member 1
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Chloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]
|
CTD |
PMID:30341573 |
|
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
|
|
G
|
Sirt3
|
sirtuin 3
|
increases stability multiple interactions
|
ISO
|
Chloroquine results in increased stability of SIRT3 mRNA Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 mRNA]; Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 protein]
|
CTD |
PMID:35302183 |
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NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
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G
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Slc12a1
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solute carrier family 12 member 1
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decreases expression
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ISO
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Chloroquine results in decreased expression of SLC12A1 protein
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CTD |
PMID:22791344 |
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NCBI chr 3:132,859,581...132,936,354
Ensembl chr 3:112,406,140...112,482,899
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G
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Slc14a2
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solute carrier family 14 member 2
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [AVP protein affects the localization of SLC14A2 protein]
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CTD |
PMID:22791344 |
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Ensembl chr18:71,612,460...71,792,968
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G
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Slc19a3
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solute carrier family 19 member 3
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Metformin]; Chloroquine inhibits the reaction [SLC19A3 protein results in increased uptake of Thiamine]
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CTD |
PMID:26528626 |
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NCBI chr 9:84,275,722...84,299,368
Ensembl chr 9:84,277,024...84,299,337
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G
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Slc22a1
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solute carrier family 22 member 1
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
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CTD |
PMID:27504015 |
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NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G
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Slc22a2
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solute carrier family 22 member 2
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [SLC22A2 protein results in increased uptake of 1-Methyl-4-phenylpyridinium]
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CTD |
PMID:27504015 |
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NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
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G
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Slc2a4
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solute carrier family 2 member 4
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affects localization multiple interactions
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EXP
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Chloroquine affects the localization of SLC2A4 protein 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [[Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose]; 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]; [[Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine affects the localization of SLC2A4 protein] which results in increased uptake of Glucose; [Chloroquine results in increased abundance of Calcium] which affects the localization of SLC2A4 protein; gallein inhibits the reaction [Chloroquine affects the localization of SLC2A4 protein]
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CTD |
PMID:27160165 |
|
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
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G
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Slc7a11
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solute carrier family 7 member 11
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SLC7A11 protein] Chloroquine inhibits the reaction [Particulate Matter results in decreased expression of SLC7A11 protein]
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CTD |
PMID:34302894 PMID:36700298 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G
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Slco1a4
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solute carrier organic anion transporter family, member 1a4
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [SLCO1A2 protein results in increased uptake of estrone sulfate]
|
CTD |
PMID:27504015 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G
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Snai1
|
snail family transcriptional repressor 1
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multiple interactions
|
EXP
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Chloroquine inhibits the reaction [Dibutyl Phthalate results in increased expression of SNAI1 mRNA]
|
CTD |
PMID:30053495 |
|
NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
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G
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Snca
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synuclein alpha
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multiple interactions increases expression
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ISO
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oxyphylla A inhibits the reaction [Chloroquine results in increased expression of SNCA protein mutant form]
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CTD |
PMID:32489702 |
|
NCBI chr 4:91,026,474...91,127,444
Ensembl chr 4:89,696,420...89,796,262
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G
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Sod1
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superoxide dismutase 1
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multiple interactions decreases expression
|
ISO
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Quercetin inhibits the reaction [Chloroquine results in decreased expression of SOD1 mRNA]
|
CTD |
PMID:23607047 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G
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Sort1
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sortilin 1
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decreases expression multiple interactions
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ISO
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Chloroquine results in decreased expression of SORT1 protein Chloroquine affects the reaction [SORT1 protein affects the reaction [LDLR protein affects the abundance of Cholesterol]]
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CTD |
PMID:25805502 PMID:30950489 |
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NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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G
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Sp1
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Sp1 transcription factor
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [[WEHI-539 co-treated with venetoclax] results in increased expression of SP1 protein]
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CTD |
PMID:35561756 |
|
NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
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G
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Sqstm1
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sequestosome 1
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multiple interactions increases expression
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ISO EXP
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[Chloroquine co-treated with Oxygen deficiency] results in increased expression of SQSTM1 protein; Chloroquine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[Simvastatin co-treated with Metformin] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [[venetoclax co-treated with WEHI-539] results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ABBV-744 results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [ANGPTL8 protein results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Artesunate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [bisphenol A results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cisplatin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [cryptotanshinone results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dactolisib results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [decabromobiphenyl ether results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Doxorubicin results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [formosanin C results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [fosbretabulin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [hydroquinone results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [Resveratrol results in increased degradation of SQSTM1 protein]; Chloroquine inhibits the reaction [SC-66 compound results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [sepantronium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Sorafenib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [alpha-Chlorohydrin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Arsenic Trioxide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [lead acetate results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [N-Methyl-3,4-methylenedioxyamphetamine results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [ovatodiolide results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [pectolinarigenin results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [sodium arsenite results in increased expression of SQSTM1 protein]; ERGIC3 protein promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein]; pectolinarigenin promotes the reaction [Chloroquine results in increased expression of SQSTM1 protein] Chloroquine inhibits the reaction [cadmium acetate results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [dehydroandrographolide inhibits the reaction [Doxorubicin results in increased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [doramectin results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Venlafaxine Hydrochloride inhibits the reaction [Rotenone results in decreased expression of SQSTM1 protein]]; Chloroquine promotes the reaction [Glucose results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [manganese chloride results in increased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Resveratrol promotes the reaction [Glucose results in increased expression of SQSTM1 protein]] [bisphenol A co-treated with Chloroquine] results in increased expression of SQSTM1 protein; Chloroquine affects the reaction [SQSTM1 protein affects the susceptibility to methylmercuric chloride]; Chloroquine inhibits the reaction [(1E,4E)-1,5-bis(2-methoxyphenyl)penta-1,4-dien-3-one inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Arsenic Trioxide results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in decreased expression of SQSTM1 protein]; Chloroquine inhibits the reaction [coenzyme Q10 promotes the reaction [Acetaminophen results in decreased expression of SQSTM1 protein]]; Chloroquine inhibits the reaction [Sunitinib results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [Benzo(a)pyrene results in decreased expression of SQSTM1 protein]; Chloroquine promotes the reaction [triethylene glycol dimethacrylate results in increased expression of SQSTM1 protein]
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CTD |
PMID:21858812 PMID:22927544 PMID:23651616 PMID:24262987 PMID:24751611 PMID:25412314 PMID:25884947 PMID:25943029 PMID:27180204 PMID:27588471 PMID:27658547 PMID:28275691 PMID:28600121 PMID:28713934 PMID:28906492 PMID:29222055 PMID:29248574 PMID:29870746 PMID:30208301 PMID:30237538 PMID:30280407 PMID:30338810 PMID:30550853 PMID:30551460 PMID:31586597 PMID:31837377 PMID:31900833 PMID:32186374 PMID:32693121 PMID:32702505 PMID:33070465 PMID:33203845 PMID:33271250 PMID:33462182 PMID:33684387 PMID:34186417 PMID:34405320 PMID:34520793 PMID:34842334 PMID:35104487 PMID:35137919 PMID:35302183 PMID:35561756 PMID:35843418 PMID:36070022 PMID:36078115 PMID:36482696 PMID:36792013 PMID:36958258 PMID:37258240 PMID:37330034 PMID:37393350 PMID:37741534 PMID:37769529 PMID:38000454 PMID:38326183 PMID:38964637 PMID:39454710 More...
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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G
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Ssb
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small RNA binding exonuclease protection factor La
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multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [SSB protein results in increased expression of CXCL8 mRNA]; Chloroquine inhibits the reaction [SSB protein results in increased secretion of CXCL8 protein]
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CTD |
PMID:25915936 |
|
NCBI chr 3:54,616,616...54,626,203
Ensembl chr 3:54,616,619...54,626,203
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G
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Star
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steroidogenic acute regulatory protein
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decreases expression
|
EXP
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Chloroquine results in decreased expression of STAR mRNA
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CTD |
PMID:19393257 |
|
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
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G
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Stc2
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stanniocalcin 2
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decreases expression
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EXP
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Chloroquine results in decreased expression of STC2 mRNA
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CTD |
PMID:19393257 |
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NCBI chr10:16,755,508...16,765,275
Ensembl chr10:16,250,853...16,262,973
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G
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Strap
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serine/threonine kinase receptor associated protein
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decreases expression
|
EXP
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Chloroquine results in decreased expression of STRAP mRNA
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CTD |
PMID:19393257 |
|
NCBI chr 4:172,377,325...172,391,573
Ensembl chr 4:170,646,001...170,660,828
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G
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Syp
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synaptophysin
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multiple interactions
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EXP
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Chloroquine inhibits the reaction [Nanotubes, Carbon results in decreased expression of SYP]
|
CTD |
PMID:26327526 |
|
NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745
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G
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Tardbp
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TAR DNA binding protein
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increases expression multiple interactions
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ISO
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Chloroquine results in increased expression of TARDBP protein Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
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CTD |
PMID:25884947 |
|
NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:159,051,799...159,062,055
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G
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Tet2
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tet methylcytosine dioxygenase 2
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multiple interactions
|
ISO
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Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 mRNA]; Chloroquine inhibits the reaction [dorsomorphin results in decreased expression of TET2 protein]
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CTD |
PMID:31900833 |
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NCBI chr 2:224,662,654...224,746,819
Ensembl chr 2:221,988,645...222,072,534
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G
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Tgfb1
|
transforming growth factor, beta 1
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multiple interactions
|
EXP
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Chloroquine promotes the reaction [Dibutyl Phthalate results in increased expression of TGFB1 protein]
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CTD |
PMID:30453174 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G
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Tgoln2
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trans-golgi network protein 2
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affects localization
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ISO
|
Chloroquine affects the localization of TGOLN2 protein
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CTD |
PMID:29940786 |
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NCBI chr 4:104,663,356...104,671,208
Ensembl chr 4:104,663,353...104,671,164
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G
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Thra
|
thyroid hormone receptor alpha
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multiple interactions
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ISO
|
Chloroquine inhibits the reaction [[THRA protein co-treated with Triiodothyronine] results in decreased expression of SQSTM1 protein]
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CTD |
PMID:24262987 |
|
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
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G
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Ticam2
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TIR domain containing adaptor molecule 2
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multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TICAM2 mRNA]
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CTD |
PMID:22341560 |
|
NCBI chr18:39,289,902...39,311,462
Ensembl chr18:39,294,453...39,311,462
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G
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Timp1
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TIMP metallopeptidase inhibitor 1
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multiple interactions decreases expression
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ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP1 protein] Chloroquine results in decreased expression of TIMP1 mRNA Chloroquine inhibits the reaction [Artesunate results in increased expression of TIMP1 mRNA]
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CTD |
PMID:22341560 PMID:30551460 |
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NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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G
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Timp2
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TIMP metallopeptidase inhibitor 2
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TIMP2 protein]
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CTD |
PMID:22341560 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
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G
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Tlr3
|
toll-like receptor 3
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [Poly I-C results in increased activity of TLR3 protein]
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CTD |
PMID:21398612 |
|
NCBI chr16:46,821,980...46,837,900
Ensembl chr16:46,822,039...46,836,545
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G
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Tlr4
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toll-like receptor 4
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multiple interactions
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ISO
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Chloroquine promotes the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of TLR4 protein]
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CTD |
PMID:22341560 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G
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Tlr7
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toll-like receptor 7
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decreases activity
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ISO
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Chloroquine results in decreased activity of TLR7 protein
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CTD |
PMID:27385120 |
|
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
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G
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Tlr8
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toll-like receptor 8
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decreases activity
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ISO
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Chloroquine results in decreased activity of TLR8 protein
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CTD |
PMID:27385120 |
|
NCBI chr X:27,091,780...27,116,092
Ensembl chr X:27,091,778...27,116,549
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G
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Tlr9
|
toll-like receptor 9
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decreases activity decreases expression multiple interactions increases expression
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ISO EXP
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Chloroquine results in decreased activity of TLR9 protein Chloroquine results in decreased expression of TLR9 protein Chloroquine inhibits the reaction [[Diethylnitrosamine co-treated with N-nitrosomorpholine] results in increased expression of TLR9 protein] Chloroquine results in increased expression of TLR9 mRNA Chloroquine inhibits the reaction [CpG ODN 2006 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [CpG ODN 2395 results in increased activity of TLR9 protein]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TLR9 mRNA]; Oxygen deficiency inhibits the reaction [Chloroquine results in increased expression of TLR9 mRNA]; TLR9 protein promotes the reaction [Oxygen deficiency promotes the reaction [Chloroquine results in increased expression of MMP13 mRNA]]
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CTD |
PMID:21398612 PMID:22595112 PMID:24273604 PMID:24990399 |
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NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796
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G
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Tm7sf2
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transmembrane 7 superfamily member 2
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decreases expression
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EXP
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Chloroquine results in decreased expression of TM7SF2 mRNA
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CTD |
PMID:19393257 |
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NCBI chr 1:203,355,930...203,360,287
Ensembl chr 1:203,355,931...203,360,270
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G
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Tnf
|
tumor necrosis factor
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decreases expression multiple interactions decreases secretion increases expression
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ISO EXP
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Chloroquine results in decreased expression of TNF protein Chloroquine inhibits the reaction [3,4-dihydroxyphenylethanol inhibits the reaction [Hydrogen Peroxide results in increased secretion of TNF protein]] [Chloroquine co-treated with TNF protein] results in increased expression of MAP1LC3B protein alternative form; Chloroquine inhibits the reaction [alpinetin inhibits the reaction [TNF protein results in increased cleavage of CASP3 protein]]; Chloroquine inhibits the reaction [hydroquinone results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of ICAM1 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of MMP9 protein]]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [TNF protein results in increased expression of PTGS2 protein]]; Chloroquine promotes the reaction [[TNF protein co-treated with Resveratrol] results in increased expression of MAP1LC3B protein alternative form]; Chloroquine promotes the reaction [TNF protein results in increased expression of and results in increased lipidation of MAP1LC3B protein]; TNF protein promotes the reaction [Chloroquine results in increased expression of and results in increased lipidation of MAP1LC3B protein] Chloroquine results in decreased secretion of TNF protein Chloroquine results in increased expression of TNF Chloroquine inhibits the reaction [CPG-oligonucleotide results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]; Chloroquine inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; Chloroquine inhibits the reaction [Resveratrol inhibits the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF mRNA]; Chloroquine promotes the reaction [[Choline deficiency co-treated with Methionine deficiency] results in increased expression of TNF protein]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]
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CTD |
PMID:8244452 PMID:9002011 PMID:9799232 PMID:10638776 PMID:15139008 PMID:22341560 PMID:24145604 PMID:26498332 PMID:28134560 PMID:31332898 PMID:31676321 PMID:33609687 PMID:35302183 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G
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Tnfrsf10b
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TNF receptor superfamily member 10b
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increases expression
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ISO
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Chloroquine results in increased expression of TNFRSF10A protein
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CTD |
PMID:27692344 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G
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Tnfrsf11a
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TNF receptor superfamily member 11A
|
multiple interactions
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ISO
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Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of TNFRSF11A mRNA]; Chloroquine inhibits the reaction [Cadmium Chloride results in increased expression of TNFRSF11A protein]
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CTD |
PMID:35843418 |
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NCBI chr13:21,928,370...21,986,719
Ensembl chr13:21,928,408...21,986,695
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G
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Tnfrsf1a
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TNF receptor superfamily member 1A
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1A protein]
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CTD |
PMID:22341560 |
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NCBI chr 4:159,837,119...159,849,817
Ensembl chr 4:158,150,820...158,163,591
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G
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Tnfrsf1b
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TNF receptor superfamily member 1B
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multiple interactions
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ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNFRSF1B protein]
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CTD |
PMID:22341560 |
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NCBI chr 5:162,356,250...162,387,411
Ensembl chr 5:157,070,642...157,104,206
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G
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Tomm20
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translocase of outer mitochondrial membrane 20
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multiple interactions
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ISO
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Chloroquine promotes the reaction [Triiodothyronine results in increased expression of TOMM20 protein]
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CTD |
PMID:30209975 |
|
NCBI chr19:71,822,429...71,832,420
Ensembl chr19:54,923,402...54,935,198
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G
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Tp53
|
tumor protein p53
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increases activity multiple interactions
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ISO
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Chloroquine results in increased activity of TP53; Chloroquine results in increased activity of TP53 protein Chloroquine inhibits the reaction [Doxorubicin results in increased expression of TP53 protein] TRP53 mutant form inhibits the reaction [Chloroquine results in increased activity of CASP3 protein]
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CTD |
PMID:11589424 PMID:12082016 PMID:18089834 PMID:22927544 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
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G
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Trib3
|
tribbles pseudokinase 3
|
increases expression multiple interactions
|
ISO
|
Chloroquine results in increased expression of TRIB3 protein 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein] 1,3-dihydroxy-4,4,5,5-tetramethyl-2-(4-carboxyphenyl)tetrahydroimidazole inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; 1-(4-(4-propionylpiperazin-1-yl)-3-(trifluoromethyl)phenyl)-9-(quinolin-3-yl)benzo(h)(1,6)naphthyridin-2(1H)-one inhibits the reaction [Chloroquine results in increased expression of TRIB3 protein]; [Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein; Betulinic Acid inhibits the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [[Bortezomib co-treated with Chloroquine] results in increased expression of TRIB3 protein]; Doxorubicin promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [[Chloroquine co-treated with Bortezomib] results in increased expression of TRIB3 protein]; Nitroprusside promotes the reaction [Chloroquine results in increased expression of TRIB3 protein]
|
CTD |
PMID:30482226 |
|
NCBI chr 3:161,269,939...161,275,533
Ensembl chr 3:140,809,043...140,814,497
|
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G
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Trim63
|
tripartite motif containing 63
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affects expression
|
EXP
|
Chloroquine affects the expression of TRIM63 mRNA
|
CTD |
PMID:19296457 |
|
NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
|
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G
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Trpc1
|
transient receptor potential cation channel, subfamily C, member 1
|
multiple interactions
|
EXP
|
Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 mRNA]; Chloroquine inhibits the reaction [Oxygen deficiency results in increased expression of TRPC1 protein]
|
CTD |
PMID:32956540 |
|
NCBI chr 8:96,263,322...96,314,220
Ensembl chr 8:96,263,329...96,314,276
|
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G
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Ubc
|
ubiquitin C
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increases expression
|
EXP
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Chloroquine results in increased expression of UBC mRNA
|
CTD |
PMID:19296457 |
|
NCBI chr12:31,239,149...31,243,924
Ensembl chr12:31,239,152...31,243,925
|
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G
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Usp2
|
ubiquitin specific peptidase 2
|
multiple interactions increases expression
|
ISO
|
Chloroquine promotes the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of USP2 mRNA]; lipopolysaccharide, E coli O55-B5 promotes the reaction [Chloroquine results in increased expression of USP2 mRNA]
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CTD |
PMID:28134560 |
|
NCBI chr 8:44,411,457...44,439,668
Ensembl chr 8:44,411,607...44,438,331
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G
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Usp25
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ubiquitin specific peptidase 25
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increases expression multiple interactions
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ISO
|
Chloroquine results in increased expression of USP25 mRNA; Chloroquine results in increased expression of USP25 protein [Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA; [lipopolysaccharide, E coli O55-B5 co-treated with Chloroquine] results in increased expression of USP25 protein; Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP25 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [[Chloroquine co-treated with lipopolysaccharide, E coli O55-B5] results in increased expression of USP25 mRNA]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 affects the localization of IRF3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased activity of and affects the localization of RELA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IFNB1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of IL6 mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of TNF mRNA]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK1 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK3 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of MAPK8 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased phosphorylation of NFKBIA protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of IL6 protein]]; USP25 protein affects the reaction [Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased secretion of TNF protein]]
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CTD |
PMID:28134560 |
|
NCBI chr11:15,603,654...15,711,356
Ensembl chr11:15,603,881...15,711,348
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G
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Usp28
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ubiquitin specific peptidase 28
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multiple interactions increases expression
|
ISO
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Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP28 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP28 mRNA]
|
CTD |
PMID:28134560 |
|
NCBI chr 8:49,325,766...49,386,229
Ensembl chr 8:49,325,867...49,386,229
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G
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Usp7
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ubiquitin specific peptidase 7
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increases expression multiple interactions
|
ISO
|
Chloroquine results in increased expression of USP7 mRNA Chloroquine inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of USP7 mRNA]; lipopolysaccharide, E coli O55-B5 inhibits the reaction [Chloroquine results in increased expression of USP7 mRNA]
|
CTD |
PMID:28134560 |
|
NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
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G
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Usp8
|
ubiquitin specific peptidase 8
|
multiple interactions
|
ISO
|
[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] promotes the reaction [Chloroquine results in increased cleavage of PARP1 protein]; Chloroquine promotes the reaction [[Cysteine Proteinase Inhibitors results in decreased activity of USP8 protein] which results in increased cleavage of PARP1 protein]
|
CTD |
PMID:35022897 |
|
NCBI chr 3:113,962,136...114,009,683
Ensembl chr 3:113,962,164...114,009,666
|
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G
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Vcp
|
valosin-containing protein
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multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [VCP protein mutant form results in decreased expression of MAP1LC3B protein]; Chloroquine inhibits the reaction [VCP protein mutant form results in increased expression of OPTN protein] Chloroquine promotes the reaction [VCP protein mutant form results in increased expression of TARDBP protein]
|
CTD |
PMID:25884947 |
|
NCBI chr 5:62,005,984...62,025,387
Ensembl chr 5:57,210,168...57,229,571
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G
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Vsnl1
|
visinin-like 1
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decreases expression
|
EXP
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Chloroquine results in decreased expression of VSNL1 mRNA
|
CTD |
PMID:19393257 |
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NCBI chr 6:34,038,641...34,159,479
Ensembl chr 6:34,038,642...34,159,479
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G
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Xcl1
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X-C motif chemokine ligand 1
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multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of XCL1 protein]
|
CTD |
PMID:22341560 |
|
NCBI chr13:77,248,687...77,252,343
Ensembl chr13:77,248,717...77,252,329
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G
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Xpo1
|
exportin 1
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multiple interactions
|
ISO
|
Chloroquine promotes the reaction [XPO1 protein binds to BECN1 protein]; Chloroquine promotes the reaction [XPO1 protein binds to YWHAQ protein]
|
CTD |
PMID:33070465 |
|
NCBI chr14:101,434,450...101,476,705
Ensembl chr14:97,233,270...97,275,498
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G
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Ywhaq
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta
|
multiple interactions
|
ISO
|
Chloroquine promotes the reaction [ABL1 protein mutant form binds to YWHAQ protein]; Chloroquine promotes the reaction [XPO1 protein binds to YWHAQ protein]
|
CTD |
PMID:33070465 |
|
NCBI chr 6:40,935,714...40,966,240
Ensembl chr 6:40,935,949...40,966,273
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|
G
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Zfp36
|
zinc finger protein 36
|
multiple interactions
|
ISO
|
Chloroquine inhibits the reaction [hydroquinone results in decreased expression of ZFP36 protein]
|
CTD |
PMID:35302183 |
|
NCBI chr 1:92,796,628...92,799,108
Ensembl chr 1:83,669,084...83,671,564
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|
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G
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Ago3
|
argonaute RISC catalytic component 3
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [Thapsigargin affects the localization of AGO3 mRNA]
|
CTD |
PMID:29576526 |
|
NCBI chr 5:138,632,367...138,714,230
Ensembl chr 5:138,639,569...138,714,230
|
|
G
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Akap9
|
A-kinase anchoring protein 9
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [sodium arsenite affects the localization of AKAP9 protein]
|
CTD |
PMID:19073175 |
|
NCBI chr 4:30,056,738...30,192,716
Ensembl chr 4:30,056,738...30,192,606
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G
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Ar
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androgen receptor
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multiple interactions
|
ISO
|
Emetine binds to and results in decreased activity of AR protein
|
CTD |
PMID:25752796 |
|
NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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G
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Brca1
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BRCA1, DNA repair associated
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multiple interactions
|
ISO
|
Emetine inhibits the reaction [Thapsigargin affects the localization of BRCA1 mRNA]
|
CTD |
PMID:29576526 |
|
NCBI chr10:86,417,441...86,477,762
Ensembl chr10:86,418,000...86,477,304
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|
G
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Caprin1
|
cell cycle associated protein 1
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [sodium arsenite affects the localization of CAPRIN1 protein]
|
CTD |
PMID:19073175 |
|
NCBI chr 3:90,152,305...90,230,447
Ensembl chr 3:90,153,620...90,230,502
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|
G
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Casp3
|
caspase 3
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increases activity
|
ISO
|
Emetine results in increased activity of CASP3 protein
|
CTD |
PMID:14502240 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G
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Casp9
|
caspase 9
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increases activity
|
ISO
|
Emetine results in increased activity of CASP9 protein
|
CTD |
PMID:14502240 |
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
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Ccar1
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cell division cycle and apoptosis regulator 1
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multiple interactions
|
ISO
|
Emetine inhibits the reaction [sodium arsenite affects the localization of CCAR1 protein]
|
CTD |
PMID:19073175 |
|
NCBI chr20:30,685,916...30,728,531
Ensembl chr20:30,685,916...30,728,526
|
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G
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Ccl2
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C-C motif chemokine ligand 2
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decreases expression
|
ISO
|
Emetine results in decreased expression of CCL2 protein
|
CTD |
PMID:20116850 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G
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Ccl3
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C-C motif chemokine ligand 3
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decreases expression
|
ISO
|
Emetine results in decreased expression of CCL3 protein
|
CTD |
PMID:20116850 |
|
NCBI chr10:68,948,889...68,950,439
Ensembl chr10:68,451,388...68,452,938
|
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G
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Ccl4
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C-C motif chemokine ligand 4
|
decreases expression
|
ISO
|
Emetine results in decreased expression of CCL4 protein
|
CTD |
PMID:20116850 |
|
NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231
|
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G
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Ccl5
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C-C motif chemokine ligand 5
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decreases expression
|
ISO
|
Emetine results in decreased expression of CCL5 protein
|
CTD |
PMID:20116850 |
|
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
|
|
G
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Creb1
|
cAMP responsive element binding protein 1
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [Thapsigargin affects the localization of CREB1 mRNA]
|
CTD |
PMID:29576526 |
|
NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
|
|
G
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Esr1
|
estrogen receptor 1
|
multiple interactions
|
ISO
|
Emetine binds to and results in decreased activity of ESR1 protein
|
CTD |
PMID:25752796 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
|
|
G
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Esr2
|
estrogen receptor 2
|
multiple interactions
|
ISO
|
Emetine binds to and results in decreased activity of ESR2 protein
|
CTD |
PMID:25752796 |
|
NCBI chr 6:100,589,553...100,645,240
Ensembl chr 6:94,809,547...94,908,919
|
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G
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Igf2bp1
|
insulin-like growth factor 2 mRNA binding protein 1
|
multiple interactions
|
ISO
|
IGF2BP1 protein affects the reaction [Emetine results in increased degradation of MYCN protein]
|
CTD |
PMID:37246217 |
|
NCBI chr10:80,908,300...80,951,097
Ensembl chr10:80,908,076...80,951,129
|
|
G
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Il6r
|
interleukin 6 receptor
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decreases expression
|
ISO
|
Emetine results in decreased expression of IL6R protein modified form
|
CTD |
PMID:20116850 |
|
NCBI chr 2:177,582,020...177,646,705
Ensembl chr 2:175,298,686...175,347,536
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G
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Mapk1
|
mitogen activated protein kinase 1
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multiple interactions decreases phosphorylation increases phosphorylation
|
ISO
|
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK1 protein] MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK1 protein]
|
CTD |
PMID:15772366 PMID:26332055 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
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G
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Mapk14
|
mitogen activated protein kinase 14
|
multiple interactions
|
ISO
|
Emetine results in increased phosphorylation of and results in increased activity of MAPK14 protein; MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP2 protein]; MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP9 protein]; MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK1 protein]; MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK3 protein]
|
CTD |
PMID:16364386 PMID:26332055 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
|
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G
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Mapk3
|
mitogen activated protein kinase 3
|
increases phosphorylation decreases phosphorylation multiple interactions
|
ISO
|
Emetine results in increased phosphorylation of MAPK3 protein Emetine results in decreased phosphorylation of MAPK3 protein MAPK14 mutant form inhibits the reaction [Emetine results in decreased phosphorylation of MAPK3 protein] 4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:15772366 PMID:26332055 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
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Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions increases phosphorylation
|
ISO
|
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK8 protein]
|
CTD |
PMID:15772366 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
|
|
G
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Mapk9
|
mitogen-activated protein kinase 9
|
multiple interactions increases phosphorylation
|
ISO
|
4-amino-5-(4-methylphenyl)-7-(tert-butyl)pyrazolo(3,4-d)pyrimidine inhibits the reaction [Emetine results in increased phosphorylation of MAPK9 protein]
|
CTD |
PMID:15772366 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
|
|
G
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Mapt
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microtubule-associated protein tau
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decreases expression
|
ISO
|
Emetine results in decreased expression of MAPT protein
|
CTD |
PMID:16930453 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
|
|
G
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Mmp2
|
matrix metallopeptidase 2
|
decreases activity multiple interactions decreases expression
|
ISO
|
Emetine results in decreased activity of MMP2 protein MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP2 protein] Emetine results in decreased expression of MMP2 mRNA
|
CTD |
PMID:26332055 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
decreases activity multiple interactions decreases expression
|
ISO
|
Emetine results in decreased activity of MMP9 protein MAPK14 mutant form inhibits the reaction [Emetine results in decreased activity of MMP9 protein] Emetine results in decreased expression of MMP9 mRNA
|
CTD |
PMID:26332055 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
|
|
G
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Mycn
|
MYCN proto-oncogene, bHLH transcription factor
|
multiple interactions increases degradation
|
ISO
|
IGF2BP1 protein affects the reaction [Emetine results in increased degradation of MYCN protein]
|
CTD |
PMID:37246217 |
|
NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590
|
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G
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Nefh
|
neurofilament heavy chain
|
decreases degradation
|
EXP
|
Emetine results in decreased degradation of NEFH mRNA
|
CTD |
PMID:1280263 |
|
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
|
|
G
|
Nefl
|
neurofilament light chain
|
decreases degradation
|
EXP
|
Emetine results in decreased degradation of NEFL mRNA
|
CTD |
PMID:1280263 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
|
|
G
|
Nefm
|
neurofilament medium chain
|
decreases degradation
|
EXP
|
Emetine results in decreased degradation of NEFM mRNA
|
CTD |
PMID:1280263 |
|
NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
|
|
G
|
Nr1h4
|
nuclear receptor subfamily 1, group H, member 4
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein]
|
CTD |
PMID:25257666 |
|
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage
|
ISO
|
Emetine results in increased cleavage of PARP1 protein
|
CTD |
PMID:21256112 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Pgr
|
progesterone receptor
|
multiple interactions
|
ISO
|
Emetine binds to and results in decreased activity of PGR protein
|
CTD |
PMID:25752796 |
|
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
|
|
G
|
Reck
|
reversion-inducing-cysteine-rich protein with kazal motifs
|
decreases expression
|
ISO
|
Emetine results in decreased expression of RECK mRNA
|
CTD |
PMID:26332055 |
|
NCBI chr 5:62,898,717...62,965,274
Ensembl chr 5:58,102,981...58,169,502
|
|
G
|
Rictor
|
RPTOR independent companion of MTOR, complex 2
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [Thapsigargin affects the localization of RICTOR mRNA]
|
CTD |
PMID:29576526 |
|
NCBI chr 2:57,539,279...57,631,291
Ensembl chr 2:55,811,322...55,901,426
|
|
G
|
Tardbp
|
TAR DNA binding protein
|
multiple interactions
|
ISO
|
Emetine affects the reaction [TARDBP protein binds to TIA1 protein]; Emetine affects the reaction [TARDBP protein binds to TIAL1 protein]
|
CTD |
PMID:19765185 |
|
NCBI chr 5:164,330,452...164,348,435
Ensembl chr 5:159,051,799...159,062,055
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
decreases activity
|
ISO
|
Emetine results in decreased activity of TGFB1 protein
|
CTD |
PMID:31652400 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
|
|
G
|
Thra
|
thyroid hormone receptor alpha
|
multiple interactions
|
ISO
|
Emetine binds to and results in decreased activity of THRA protein
|
CTD |
PMID:25752796 |
|
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
|
|
G
|
Thrb
|
thyroid hormone receptor beta
|
multiple interactions
|
ISO
|
Emetine binds to and results in decreased activity of THRB protein
|
CTD |
PMID:25752796 |
|
NCBI chr15:7,685,180...8,031,920
Ensembl chr15:7,685,180...7,882,916
|
|
G
|
Tia1
|
TIA1 cytotoxic granule-associated RNA binding protein
|
multiple interactions
|
ISO
|
Emetine affects the reaction [TARDBP protein binds to TIA1 protein]
|
CTD |
PMID:19765185 |
|
NCBI chr 4:118,852,765...118,883,252
Ensembl chr 4:118,852,837...118,880,586
|
|
G
|
Tial1
|
Tia1 cytotoxic granule-associated RNA binding protein-like 1
|
multiple interactions
|
ISO
|
Emetine affects the reaction [TARDBP protein binds to TIAL1 protein]
|
CTD |
PMID:19765185 |
|
NCBI chr 1:183,008,358...183,045,092
Ensembl chr 1:183,009,253...183,031,637
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
decreases expression
|
ISO
|
Emetine results in decreased expression of VEGFA protein
|
CTD |
PMID:20116850 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
|
|
G
|
Xiap
|
X-linked inhibitor of apoptosis
|
multiple interactions
|
ISO
|
Emetine inhibits the reaction [Thapsigargin affects the localization of XIAP mRNA]
|
CTD |
PMID:29576526 |
|
NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700
|
|
|
G
|
Alpl
|
alkaline phosphatase, biomineralization associated
|
affects expression multiple interactions
|
ISO
|
Hydroxychloroquine affects the expression of ALPL mRNA Hydroxychloroquine affects the reaction [Simvastatin affects the expression of ALPL mRNA]
|
CTD |
PMID:28975700 |
|
NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases activity
|
ISO
|
bafilomycin A1 inhibits the reaction [Hydroxychloroquine results in increased activity of BAX protein]
|
CTD |
PMID:12813466 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bbc3
|
Bcl-2 binding component 3
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of BBC3 mRNA
|
CTD |
PMID:38311193 |
|
NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [beta-ionone results in decreased expression of BCL2 protein]
|
CTD |
PMID:36843289 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions increases cleavage increases activity
|
ISO
|
benzyloxycarbonylvalyl-alanyl-aspartyl fluoromethyl ketone inhibits the reaction [Hydroxychloroquine results in increased cleavage of CASP3 protein]; FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein]
|
CTD |
PMID:12813466 PMID:16734620 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of CCL2 mRNA
|
CTD |
PMID:15139008 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
|
|
G
|
Cd14
|
CD14 molecule
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD14 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr18:28,609,558...28,611,409
Ensembl chr18:28,335,340...28,337,261
|
|
G
|
Cd19
|
CD19 molecule
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD19 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 1:190,417,853...190,424,494
Ensembl chr 1:180,987,286...180,993,975
|
|
G
|
Cd27
|
CD27 molecule
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD27 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 4:159,716,932...159,721,823
Ensembl chr 4:158,030,703...158,035,592
|
|
G
|
Cd38
|
CD38 molecule
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD38 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
|
|
G
|
Cd3d
|
CD3 delta subunit of T-cell receptor complex
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD3D mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 8:54,184,573...54,190,112
Ensembl chr 8:45,288,749...45,301,809
|
|
G
|
Cd40lg
|
CD40 ligand
|
decreases expression
|
ISO
|
Hydroxychloroquine results in decreased expression of CD40LG protein
|
CTD |
PMID:28793932 |
|
NCBI chr X:140,164,341...140,176,057
Ensembl chr X:135,126,969...135,138,306
|
|
G
|
Cd74
|
CD74 molecule
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CD74 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr18:56,527,071...56,536,406
Ensembl chr18:54,256,778...54,266,003
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of CDKN1A mRNA
|
CTD |
PMID:38311193 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Cflar
|
CASP8 and FADD-like apoptosis regulator
|
decreases expression
|
ISO
|
Hydroxychloroquine results in decreased expression of CFLAR mRNA; Hydroxychloroquine results in decreased expression of CFLAR protein
|
CTD |
PMID:16734620 |
|
NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
|
|
G
|
Cldn1
|
claudin 1
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of CLDN1 mRNA
|
CTD |
PMID:25752684 |
|
NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724
|
|
G
|
Ctla4
|
cytotoxic T-lymphocyte-associated protein 4
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CTLA4 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 9:69,812,859...69,819,959
Ensembl chr 9:62,319,312...62,324,963
|
|
G
|
Ctsb
|
cathepsin B
|
affects localization multiple interactions
|
ISO
|
Hydroxychloroquine affects the localization of CTSB protein bafilomycin A1 inhibits the reaction [Hydroxychloroquine affects the localization of CTSB protein]
|
CTD |
PMID:12813466 |
|
NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
|
|
G
|
Cxcl1
|
C-X-C motif chemokine ligand 1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
|
|
G
|
Cxcl10
|
C-X-C motif chemokine ligand 10
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of CXCL10 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
|
|
G
|
Cxcl3
|
C-X-C motif chemokine ligand 3
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of CXCL1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G
|
Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
|
multiple interactions decreases activity
|
ISO
|
Hydroxychloroquine inhibits the reaction [CYP2D6 protein results in increased metabolism of Metoprolol] Hydroxychloroquine results in decreased activity of CYP2D6 protein
|
CTD |
PMID:10848718 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
|
|
G
|
Ddb2
|
damage specific DNA binding protein 2
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of DDB2 mRNA
|
CTD |
PMID:38311193 |
|
NCBI chr 3:77,185,114...77,207,650
Ensembl chr 3:77,185,109...77,207,631
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of DDIT3 mRNA
|
CTD |
PMID:38311193 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
|
|
G
|
Dhcr7
|
7-dehydrocholesterol reductase
|
affects expression multiple interactions
|
ISO
|
Hydroxychloroquine affects the expression of DHCR7 mRNA Hydroxychloroquine affects the reaction [Simvastatin affects the expression of DHCR7 mRNA]
|
CTD |
PMID:28975700 |
|
NCBI chr 1:199,015,081...199,031,055
Ensembl chr 1:199,015,081...199,031,055
|
|
G
|
Ern1
|
endoplasmic reticulum to nucleus signaling 1
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of ERN1 protein
|
CTD |
PMID:25321315 |
|
NCBI chr10:91,826,663...91,920,976
Ensembl chr10:91,330,654...91,421,029
|
|
G
|
Fas
|
Fas cell surface death receptor
|
multiple interactions
|
ISO
|
FAS protein affects the reaction [Hydroxychloroquine results in increased activity of CASP3 protein]
|
CTD |
PMID:16734620 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
|
|
G
|
Gadd45a
|
growth arrest and DNA-damage-inducible, alpha
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of GADD45A mRNA
|
CTD |
PMID:38311193 |
|
NCBI chr 4:97,484,497...97,486,799
Ensembl chr 4:96,154,789...96,157,115
|
|
G
|
H2ax
|
H2A.X variant histone
|
increases phosphorylation
|
ISO
|
Hydroxychloroquine results in increased phosphorylation of H2AX protein
|
CTD |
PMID:38311193 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
|
|
G
|
Hmgcr
|
3-hydroxy-3-methylglutaryl-CoA reductase
|
multiple interactions affects expression
|
ISO
|
Simvastatin affects the reaction [Hydroxychloroquine affects the expression of HMGCR mRNA]
|
CTD |
PMID:28975700 |
|
NCBI chr 2:29,732,163...29,754,276
Ensembl chr 2:27,997,525...28,019,703
|
|
G
|
Ifih1
|
interferon induced with helicase C domain 1
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of IFIH1 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 3:67,635,924...67,683,968
Ensembl chr 3:47,227,364...47,275,456
|
|
G
|
Ifit3
|
interferon-induced protein with tetratricopeptide repeats 3
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of IFIT3 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 1:232,114,166...232,119,311
Ensembl chr 1:232,114,166...232,119,307
|
|
G
|
Ifnb1
|
interferon beta 1
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of IFNB1 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
|
|
G
|
Il10
|
interleukin 10
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL10 protein
|
CTD |
PMID:31082466 |
|
NCBI chr13:45,024,921...45,029,586
Ensembl chr13:42,472,839...42,477,313
|
|
G
|
Il10ra
|
interleukin 10 receptor subunit alpha
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IL10RA mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 8:54,459,754...54,474,786
Ensembl chr 8:45,563,137...45,578,061
|
|
G
|
Il12b
|
interleukin 12B
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of IL12B mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide] Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of IL1B protein]
|
CTD |
PMID:16393772 PMID:32314717 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il23a
|
interleukin 23 subunit alpha
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of IL23A mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions increases expression
|
ISO
|
[Hydroxychloroquine co-treated with Imiquimod] results in increased secretion of IL6 protein; [Hydroxychloroquine co-treated with ODN2006] results in increased secretion of IL6 protein; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein] Hydroxychloroquine results in increased expression of IL6 mRNA
|
CTD |
PMID:9002011 PMID:25321315 PMID:31082466 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Irf3
|
interferon regulatory factor 3
|
increases expression multiple interactions increases phosphorylation
|
ISO
|
Hydroxychloroquine results in increased expression of IRF3 mRNA phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of IRF3 protein]
|
CTD |
PMID:25321315 |
|
NCBI chr 1:95,479,966...95,484,926
Ensembl chr 1:95,479,821...95,484,935
|
|
G
|
Irf4
|
interferon regulatory factor 4
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of IRF4 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr17:33,930,460...33,948,842
Ensembl chr17:33,721,811...33,740,070
|
|
G
|
Irf7
|
interferon regulatory factor 7
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of IRF7 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 1:196,367,380...196,370,943
Ensembl chr 1:196,367,361...196,370,832
|
|
G
|
Itk
|
IL2-inducible T-cell kinase
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of ITK mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr10:31,254,667...31,316,004
Ensembl chr10:30,753,344...30,814,685
|
|
G
|
Jchain
|
joining chain of multimeric IgA and IgM
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of JCHAIN mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr14:19,822,976...19,831,072
Ensembl chr14:19,538,952...19,546,298
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
increases phosphorylation multiple interactions
|
ISO
|
Hydroxychloroquine results in increased phosphorylation of JUN protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased phosphorylation of JUN protein]
|
CTD |
PMID:25321315 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
|
|
G
|
Kcnh2
|
potassium voltage-gated channel subfamily H member 2
|
multiple interactions
|
ISO
|
[Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein] which results in decreased export of Potassium; Hydroxychloroquine binds to and results in decreased activity of KCNH2 protein
|
CTD |
PMID:34058295 |
|
NCBI chr 4:11,719,357...11,751,424
Ensembl chr 4:10,826,928...10,859,008
|
|
G
|
Lck
|
LCK proto-oncogene, Src family tyrosine kinase
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of LCK mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 5:147,172,642...147,201,267
Ensembl chr 5:141,888,326...141,903,794
|
|
G
|
Mavs
|
mitochondrial antiviral signaling protein
|
increases expression multiple interactions
|
ISO
|
Hydroxychloroquine results in increased expression of MAVS mRNA; Hydroxychloroquine results in increased expression of MAVS protein phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased expression of MAVS protein]
|
CTD |
PMID:25321315 |
|
NCBI chr 3:138,904,673...138,919,129
Ensembl chr 3:118,451,743...118,466,094
|
|
G
|
Mmp1
|
matrix metallopeptidase 1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MMP1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions decreases expression
|
ISO
|
Sirolimus inhibits the reaction [Hydroxychloroquine results in decreased expression of MMP2 protein] Hydroxychloroquine results in decreased expression of MMP2 mRNA; Hydroxychloroquine results in decreased expression of MMP2 protein
|
CTD |
PMID:34278709 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
|
|
G
|
Ms4a1
|
membrane spanning 4-domains A1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of MS4A1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 1:217,331,274...217,351,934
Ensembl chr 1:207,906,374...207,918,512
|
|
G
|
Mvp
|
major vault protein
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of MVP mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 1:191,025,259...191,052,866
Ensembl chr 1:181,594,734...181,622,380
|
|
G
|
Nfatc1
|
nuclear factor of activated T-cells 1
|
affects expression
|
ISO
|
Hydroxychloroquine affects the expression of NFATC1 protein
|
CTD |
PMID:28793932 |
|
NCBI chr18:76,321,386...76,430,997
Ensembl chr18:74,046,904...74,156,028
|
|
G
|
Nfatc2
|
nuclear factor of activated T-cells 2
|
affects localization
|
ISO
|
Hydroxychloroquine affects the localization of NFATC2 protein
|
CTD |
PMID:28793932 |
|
NCBI chr 3:177,615,189...177,747,493
Ensembl chr 3:157,198,872...157,328,325
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions increases degradation
|
ISO
|
phenyl-N-tert-butylnitrone inhibits the reaction [Hydroxychloroquine results in increased degradation of NFKBIA protein]
|
CTD |
PMID:25321315 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [[IL1B protein results in increased expression of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]
|
CTD |
PMID:16393772 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
|
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G
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Ocln
|
occludin
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increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of OCLN mRNA
|
CTD |
PMID:25752684 |
|
NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
|
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G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [beta-ionone results in increased cleavage of PARP1 protein]
|
CTD |
PMID:36843289 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
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G
|
Ppp1r15a
|
protein phosphatase 1, regulatory subunit 15A
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of PPP1R15A mRNA
|
CTD |
PMID:38311193 |
|
NCBI chr 1:105,136,521...105,139,596
Ensembl chr 1:96,000,058...96,003,171
|
|
G
|
Ppt1
|
palmitoyl-protein thioesterase 1
|
multiple interactions
|
ISO
|
Hydroxychloroquine binds to and results in decreased activity of PPT1 protein
|
CTD |
PMID:30442709 |
|
NCBI chr 5:140,406,318...140,427,201
Ensembl chr 5:135,121,163...135,142,048
|
|
G
|
Prdm1
|
PR/SET domain 1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of PRDM1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr20:49,542,465...49,564,088
Ensembl chr20:47,959,858...47,981,488
|
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G
|
Rasgrp1
|
RAS guanyl releasing protein 1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of RASGRP1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 3:124,624,039...124,684,079
Ensembl chr 3:104,170,013...104,230,056
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of RELA protein
|
CTD |
PMID:25321315 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Rig1
|
RNA sensor RIG-1
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increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of RIGI mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 5:60,117,398...60,165,995
Ensembl chr 5:55,321,235...55,370,819
|
|
G
|
Rsad2
|
radical S-adenosyl methionine domain containing 2
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of RSAD2 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 6:48,774,985...48,788,245
Ensembl chr 6:43,047,658...43,059,699
|
|
G
|
Sdc1
|
syndecan 1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SDC1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr 6:37,282,041...37,304,503
Ensembl chr 6:31,562,739...31,585,264
|
|
G
|
Serpine1
|
serpin family E member 1
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 mRNA]; Hydroxychloroquine inhibits the reaction [Poly I-C results in increased expression of SERPINE1 protein]
|
CTD |
PMID:30341573 |
|
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
|
|
G
|
Slamf7
|
SLAM family member 7
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of SLAMF7 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr13:84,135,656...84,154,528
Ensembl chr13:84,136,899...84,154,105
|
|
G
|
Sqstm1
|
sequestosome 1
|
multiple interactions increases expression
|
ISO
|
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of SQSTM1 protein]] Hydroxychloroquine results in increased expression of SQSTM1 protein [Dronabinol co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein; [HU 211 co-treated with Hydroxychloroquine] results in increased expression of SQSTM1 protein
|
CTD |
PMID:29426000 PMID:32773031 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
|
|
G
|
Tlr7
|
toll-like receptor 7
|
decreases expression
|
ISO
|
Hydroxychloroquine results in decreased expression of TLR7 protein
|
CTD |
PMID:22513098 |
|
NCBI chr X:27,027,380...27,054,309
Ensembl chr X:27,027,425...27,054,754
|
|
G
|
Tlr9
|
toll-like receptor 9
|
decreases expression multiple interactions
|
ISO
|
Hydroxychloroquine results in decreased expression of TLR9 protein Hydroxychloroquine inhibits the reaction [Fluorouracil results in increased secretion of TLR9 protein]
|
CTD |
PMID:22513098 PMID:32314717 |
|
NCBI chr 8:115,743,407...115,747,523
Ensembl chr 8:106,864,680...106,868,796
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions increases expression
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNF mRNA; Hydroxychloroquine inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] Hydroxychloroquine results in increased expression of TNF mRNA
|
CTD |
PMID:9002011 PMID:25321315 PMID:28863153 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G
|
Tnfrsf17
|
TNF receptor superfamily member 17
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of TNFRSF17 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr10:4,301,023...4,306,889
Ensembl chr10:4,301,038...4,306,788
|
|
G
|
Tp53
|
tumor protein p53
|
multiple interactions
|
ISO
|
2-morpholin-4-yl-6-thianthren-1-yl-pyran-4-one inhibits the reaction [Hydroxychloroquine results in increased expression of TP53 protein]; [Hydroxychloroquine co-treated with Acetylcysteine] results in decreased localization of TP53 protein
|
CTD |
PMID:38311193 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
|
G
|
Traf3
|
Tnf receptor-associated factor 3
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of TRAF3 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 6:130,199,696...130,307,168
Ensembl chr 6:130,206,484...130,305,481
|
|
G
|
Traf6
|
TNF receptor associated factor 6
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of TRAF6 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
|
|
G
|
Trim21
|
tripartite motif-containing 21
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of TRIM21 mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr 1:156,964,896...156,987,504
Ensembl chr 1:156,964,913...156,987,440
|
|
G
|
Txnip
|
thioredoxin interacting protein
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [Metformin inhibits the reaction [Galactose results in increased expression of TXNIP protein]]
|
CTD |
PMID:29426000 |
|
NCBI chr 2:186,781,933...186,785,736
Ensembl chr 2:184,092,991...184,096,886
|
|
G
|
Uxt
|
ubiquitously-expressed, prefoldin-like chaperone
|
increases expression
|
ISO
|
Hydroxychloroquine results in increased expression of UXT mRNA
|
CTD |
PMID:25321315 |
|
NCBI chr X:3,679,630...3,691,944
Ensembl chr X:1,126,162...1,138,663
|
|
G
|
Vcl
|
vinculin
|
multiple interactions
|
ISO
|
Hydroxychloroquine inhibits the reaction [[Dexamethasone co-treated with beta-glycerophosphoric acid] results in increased expression of VCL protein]
|
CTD |
PMID:28975700 |
|
NCBI chr15:3,315,069...3,404,891
Ensembl chr15:3,265,815...3,355,606
|
|
G
|
Xbp1
|
X-box binding protein 1
|
multiple interactions
|
ISO
|
[Hydroxychloroquine co-treated with Methotrexate co-treated with Sulfasalazine] results in decreased expression of XBP1 mRNA
|
CTD |
PMID:28863153 |
|
NCBI chr14:84,604,623...84,609,707
Ensembl chr14:80,390,643...80,395,693
|
|
|
G
|
Abcb1a
|
ATP binding cassette subfamily B member 1A
|
decreases expression
|
ISO EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1 protein
|
CTD |
PMID:23466342 PMID:27888070 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
|
|
G
|
Abcb1b
|
ATP-binding cassette, sub-family B member 1B
|
multiple interactions decreases expression
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Curcumin results in decreased expression of ABCB1B protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCB1B protein
|
CTD |
PMID:18006147 |
|
NCBI chr 4:26,197,706...26,280,156
Ensembl chr 4:25,242,798...25,325,199
|
|
G
|
Abcc1
|
ATP binding cassette subfamily C member 1
|
decreases expression
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC1 protein
|
CTD |
PMID:27888070 |
|
NCBI chr10:1,022,041...1,162,431
Ensembl chr10:531,812...655,114
|
|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of ABCC2 mRNA]
|
CTD |
PMID:15896333 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
|
|
G
|
Abcc5
|
ATP binding cassette subfamily C member 5
|
decreases expression
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ABCC5 protein
|
CTD |
PMID:23994249 |
|
NCBI chr11:93,975,579...94,071,659
Ensembl chr11:80,473,872...80,567,253
|
|
G
|
Abcg2
|
ATP binding cassette subfamily G member 2
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein]
|
CTD |
PMID:21712253 |
|
NCBI chr 4:89,006,056...89,132,915
Ensembl chr 4:87,745,319...87,802,409
|
|
G
|
Abl1
|
ABL proto-oncogene 1, non-receptor tyrosine kinase
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]
|
CTD |
PMID:16849647 |
|
NCBI chr 3:35,377,587...35,480,843
Ensembl chr 3:14,979,853...15,083,065
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of ACTA2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of ACTA2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of ACTA2 protein]
|
CTD |
PMID:33895847 PMID:39353502 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
|
|
G
|
Acvr2b
|
activin A receptor type 2B
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of ACVR2B mRNA]
|
CTD |
PMID:12710931 |
|
NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
|
|
G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein]
|
CTD |
PMID:19356108 |
|
NCBI chr11:91,226,524...91,240,244
Ensembl chr11:77,721,912...77,735,564
|
|
G
|
Adora2b
|
adenosine A2B receptor
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of and results in decreased activity of GPX4 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of SLC7A11 protein]]
|
CTD |
PMID:38174997 |
|
NCBI chr10:46,940,394...46,956,772
Ensembl chr10:46,940,384...46,956,772
|
|
G
|
Adra1a
|
adrenoceptor alpha 1A
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[cirazoline results in increased activity of ADRA1A protein] which results in increased transport of Glucose]
|
CTD |
PMID:15550506 |
|
NCBI chr15:45,005,648...45,111,416
Ensembl chr15:40,832,534...40,927,500
|
|
G
|
Ager
|
advanced glycosylation end product-specific receptor
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of AGER protein]
|
CTD |
PMID:21807062 |
|
NCBI chr20:4,152,758...4,155,956
Ensembl chr20:4,147,890...4,151,078
|
|
G
|
Agt
|
angiotensinogen
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]
|
CTD |
PMID:15121739 PMID:16325820 PMID:23300732 PMID:25398788 |
|
NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
|
|
G
|
Ahr
|
aryl hydrocarbon receptor
|
increases expression multiple interactions decreases expression
|
EXP ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AHR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AHR mRNA
|
CTD |
PMID:22406437 PMID:27020609 |
|
NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
|
|
G
|
Akr1b1
|
aldo-keto reductase family 1 member B1
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of AKR1B1 mRNA]
|
CTD |
PMID:17640564 |
|
NCBI chr 4:63,899,222...63,913,315
Ensembl chr 4:62,932,031...62,946,157
|
|
G
|
Akr1b10
|
aldo-keto reductase family 1 member B10
|
decreases expression
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKR1B10 protein
|
CTD |
PMID:23994249 |
|
NCBI chr 4:64,005,632...64,027,860
Ensembl chr 4:63,040,169...63,053,852
|
|
G
|
Akr1c2
|
aldo-keto reductase family 1, member C2
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [panaxytriol results in increased activity of AKR1C2 protein]
|
CTD |
PMID:18826220 |
|
NCBI chr17:65,759,778...65,808,013
Ensembl chr17:65,759,788...65,775,764
|
|
G
|
Akr1c3
|
aldo-keto reductase family 1, member C3
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium acetate results in increased expression of AKR1C3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [panaxytriol results in increased activity of AKR1C3 protein]
|
CTD |
PMID:18826220 PMID:21787718 |
|
NCBI chr17:71,020,884...71,037,779
Ensembl chr17:66,110,963...66,127,873
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
increases expression decreases reaction decreases phosphorylation multiple interactions decreases expression decreases activity
|
ISO EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of AKT1 protein LY294002 inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Glucose co-treated with Calcitriol] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin promotes the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mercuric Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Methylmercury Compounds results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [VEGFC protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of and results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with intybin] results in increased phosphorylation of AKT1 protein; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cotinine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Furazolidone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hemistepsin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphocreatine inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cisplatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [di-n-propyldithiocarbamate results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of and results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [quinocetone results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of AKT1 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Estradiol] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] results in decreased phosphorylation of AKT1 protein; [4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased phosphorylation of AKT1 protein]; [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [Formaldehyde co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [IGF1 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; [sodium arsenite co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Arsenic Trioxide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Cisplatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-aminoisoquinolinone co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Capsaicin co-treated with Oxygen deficiency co-treated with Oxygen] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Selegiline co-treated with 1-Methyl-4-phenylpyridinium] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deuterohemin-alanyl-histidyl-threonyl-valyl-glutamyl-lysine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [diallyl trisulfide inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased activity of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Roflumilast promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [wendan inhibits the reaction [Doxorubicin results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of AKT1 protein; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AKT1 protein
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CTD RGD |
PMID:11306697 PMID:11788791 PMID:12438947 PMID:12511591 PMID:12556562 PMID:12640124 PMID:12710931 PMID:12821261 PMID:12834810 PMID:14755253 PMID:14757120 PMID:14762343 PMID:15001399 PMID:15028728 PMID:15050414 PMID:15177934 PMID:15178407 PMID:15213310 PMID:15339911 PMID:15631803 PMID:15695173 PMID:15845746 PMID:15897870 PMID:15919668 PMID:15956784 PMID:16018989 PMID:16059913 PMID:16168102 PMID:16179367 PMID:16204373 PMID:16211241 PMID:16256798 PMID:16275998 PMID:16288212 PMID:16343977 PMID:16434995 PMID:16472761 PMID:16619521 PMID:16648635 PMID:16682453 PMID:16731823 PMID:16763222 PMID:16973122 PMID:17172471 PMID:17259349 PMID:17324588 PMID:17346750 PMID:17464197 PMID:17513037 PMID:17550345 PMID:17583570 PMID:17623046 PMID:17684018 PMID:17823925 PMID:17922026 PMID:17962351 PMID:18096819 PMID:18201823 PMID:18276108 PMID:18359480 PMID:18388193 PMID:18622747 PMID:18948619 PMID:19011674 PMID:19038232 PMID:19059400 PMID:19073151 PMID:19139269 PMID:19176369 PMID:19233221 PMID:19299917 PMID:19356108 PMID:19457607 PMID:19561517 PMID:19661335 PMID:19781563 PMID:19814765 PMID:19881297 PMID:19906781 PMID:19956873 PMID:19962417 PMID:20361045 PMID:20386985 PMID:20464445 PMID:20562903 PMID:20600219 PMID:20610540 PMID:20657188 PMID:20658310 PMID:20938987 PMID:21055460 PMID:21138475 PMID:21474332 PMID:21594580 PMID:21655183 PMID:21803128 PMID:21807062 PMID:21820214 PMID:21821001 PMID:21837363 PMID:21976531 PMID:22019741 PMID:22040890 PMID:22046442 PMID:22545124 PMID:22556157 PMID:22687995 PMID:23000059 PMID:23159718 PMID:23285096 PMID:23300809 PMID:23352507 PMID:23453443 PMID:23466500 PMID:23735482 PMID:23793038 PMID:23958495 PMID:24057571 PMID:24122885 PMID:24361488 PMID:24449419 PMID:24462917 PMID:24680926 PMID:24727557 PMID:24875536 PMID:24876378 PMID:24898257 PMID:24946264 PMID:25118938 PMID:25171655 PMID:25203460 PMID:25303017 PMID:25398788 PMID:25471227 PMID:25597859 PMID:25644787 PMID:25773745 PMID:25784559 PMID:25866362 PMID:26048653 PMID:26089345 PMID:26282490 PMID:26364587 PMID:26506538 PMID:26687534 PMID:26790143 PMID:26887589 PMID:26942697 PMID:26974319 PMID:27049278 PMID:27050422 PMID:27098396 PMID:27295300 PMID:27312872 PMID:27338800 PMID:27431321 PMID:27542212 PMID:27658547 PMID:28011163 PMID:28302560 PMID:28465020 PMID:28756148 PMID:28940008 PMID:29061316 PMID:29169284 PMID:29186614 PMID:29505745 PMID:29510123 PMID:30205135 PMID:30542770 PMID:30600586 PMID:30726812 PMID:30851366 PMID:31068539 PMID:31445927 PMID:31614463 PMID:31715269 PMID:31743544 PMID:31758290 PMID:31830547 PMID:32044604 PMID:32298737 PMID:32602595 PMID:32613688 PMID:32687844 PMID:32877639 PMID:33131013 PMID:33270355 PMID:33359794 PMID:33450223 PMID:33462182 PMID:33516933 PMID:33581215 PMID:33618463 PMID:33689844 PMID:33771252 PMID:33895847 PMID:34147605 PMID:34784199 PMID:34859534 PMID:34896440 PMID:35024177 PMID:35122754 PMID:35568058 PMID:35901927 PMID:35929799 PMID:36252918 PMID:36343798 PMID:36898572 PMID:36940862 PMID:37051183 PMID:37217155 PMID:37648050 PMID:37853848 PMID:37934488 PMID:38180513 PMID:38336255 PMID:38477013 PMID:38729284 PMID:39067743 PMID:39353502 PMID:17272396 More...
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RGD:152177689 |
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G
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Akt1s1
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AKT1 substrate 1
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decreases phosphorylation
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1S1 protein
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CTD |
PMID:17457363 |
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NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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G
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Alpl
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alkaline phosphatase, biomineralization associated
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of ALPL protein]]
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CTD |
PMID:33450223 |
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NCBI chr 5:155,234,770...155,289,785
Ensembl chr 5:149,951,409...150,006,446
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G
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Angpt1
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angiopoietin 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein results in decreased susceptibility to Doxorubicin]
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CTD |
PMID:15763944 |
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NCBI chr 7:75,415,959...75,668,696
Ensembl chr 7:73,531,486...73,784,067
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G
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Angpt2
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angiopoietin 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of MKI67 protein]
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CTD |
PMID:31838054 |
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NCBI chr16:71,088,364...71,138,805
Ensembl chr16:71,088,364...71,138,804
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G
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Apln
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apelin
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increases expression multiple interactions increases secretion
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of APLN mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Eicosapentaenoic Acid results in increased expression of APLN mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased secretion of APLN protein
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CTD |
PMID:20352620 PMID:21461750 |
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NCBI chr X:127,180,801...127,213,567
Ensembl chr X:127,203,823...127,213,391
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G
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App
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amyloid beta precursor protein
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Clioquinol co-treated with Copper] results in decreased expression of APP protein alternative form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of and affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxyphylla A inhibits the reaction [APP protein results in increased abundance of amyloid beta-protein (1-40)]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [coenzyme Q10 results in decreased susceptibility to APP protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lovastatin results in increased secretion of APP protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in decreased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in increased activity of CASP3 protein]
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CTD |
PMID:16648635 PMID:19741129 PMID:22186599 PMID:28756148 PMID:35024177 |
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NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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G
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Aqp3
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aquaporin 3 (Gill blood group)
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein]
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CTD |
PMID:16848764 PMID:18214481 |
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NCBI chr 5:61,035,165...61,040,683
Ensembl chr 5:56,239,201...56,244,720
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G
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Aqp9
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aquaporin 9
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dihydrotestosterone results in decreased expression of AQP9 mRNA]
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CTD |
PMID:20378617 |
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NCBI chr 8:71,797,231...71,837,485
Ensembl chr 8:71,797,234...71,837,395
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G
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Ar
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androgen receptor
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methoxyacetic acid promotes the reaction [Testosterone results in increased activity of AR protein]]
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CTD |
PMID:16472761 PMID:18486176 PMID:19059400 |
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NCBI chr X:67,135,317...67,304,476
Ensembl chr X:63,104,771...63,273,925
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G
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Arg2
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arginase 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of ARG2 protein]
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CTD |
PMID:24951775 |
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NCBI chr 6:97,936,002...97,961,379
Ensembl chr 6:97,936,002...97,961,378
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G
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Atf4
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activating transcription factor 4
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]; Cycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]; SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of ATF4]]
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CTD |
PMID:24057571 |
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NCBI chr 7:113,684,681...113,686,739
Ensembl chr 7:111,804,183...111,806,446
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G
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Atf6
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activating transcription factor 6
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multiple interactions
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ISO EXP
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[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of ATF6 protein]]
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CTD |
PMID:24898257 PMID:31433112 |
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NCBI chr13:82,927,579...83,106,381
Ensembl chr13:82,930,034...83,107,177
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G
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Atg5
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autophagy related 5
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG5 mRNA]
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CTD |
PMID:35568058 |
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NCBI chr20:49,380,835...49,471,826
Ensembl chr20:47,798,290...47,889,209
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G
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Atg7
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autophagy related 7
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of ATG7 protein]
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CTD |
PMID:35568058 |
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NCBI chr 4:149,390,000...149,597,534
Ensembl chr 4:147,718,752...147,925,593
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G
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Atm
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ATM serine/threonine kinase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of ATM protein]
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CTD |
PMID:19038232 |
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NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
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G
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Aurkb
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aurora kinase B
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AURKB protein
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CTD |
PMID:21530604 |
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NCBI chr10:54,243,116...54,249,675
Ensembl chr10:53,745,142...53,750,837
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G
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Axin2
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axin 2
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased expression of AXIN2 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of AXIN2 mRNA
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CTD |
PMID:31758290 |
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NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231
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G
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Bad
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BCL2-associated agonist of cell death
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multiple interactions decreases phosphorylation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and results in decreased activity of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [polyphenon E results in decreased phosphorylation of BAD protein]; polyphenon E promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of BAD protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BAD protein modified form]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of BAD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Rotenone results in increased phosphorylation of BAD protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of BAD protein]
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CTD |
PMID:12438947 PMID:12970779 PMID:14628071 PMID:17123556 PMID:17293559 PMID:17559149 PMID:19596284 PMID:23285096 PMID:25895139 More...
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NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
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G
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Bax
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BCL2 associated X, apoptosis regulator
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affects localization increases expression multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of BAX protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BAX protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of BAX protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in increased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in decreased expression of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid inhibits the reaction [Nitroprusside affects the localization of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Stilbenes analog affects the localization of BAX protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased expression of BAX protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with arsenic disulfide] results in increased expression of BAX protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with TNFSF10 protein] results in increased activity of BAX protein; [Arsenic Trioxide co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of BAX protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]
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CTD |
PMID:15665116 PMID:15942663 PMID:18449500 PMID:20097879 PMID:20386985 PMID:20856197 PMID:22178905 PMID:23201927 PMID:25895139 PMID:27032576 PMID:28465020 PMID:29054700 PMID:29186614 PMID:30365941 PMID:30542770 PMID:31433112 PMID:31838054 PMID:32602595 PMID:32877639 PMID:33689844 PMID:34859534 PMID:34897970 PMID:36343798 PMID:37934488 PMID:38336255 More...
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NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G
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Bbc3
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Bcl-2 binding component 3
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multiple interactions increases expression
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ISO EXP
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[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BBC3 protein
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CTD |
PMID:20856197 PMID:24567336 |
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NCBI chr 1:86,141,450...86,150,666
Ensembl chr 1:77,014,543...77,022,509
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G
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Bcl2
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BCL2, apoptosis regulator
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multiple interactions decreases expression increases expression increases phosphorylation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Emodin affects the expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of BCL2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with arsenic disulfide] results in decreased expression of BCL2 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; BCL2 protein results in decreased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BCL2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carnitine results in increased phosphorylation of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide results in increased expression of BCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Dithionite co-treated with Glucose deficiency] results in decreased expression of BCL2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BCL2 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of BCL2 protein
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CTD |
PMID:16018989 PMID:20386985 PMID:20856197 PMID:21130731 PMID:21800153 PMID:21803128 PMID:22046442 PMID:23201927 PMID:23352507 PMID:25895139 PMID:25955216 PMID:27032576 PMID:28185818 PMID:28465020 PMID:29054700 PMID:29186614 PMID:30365941 PMID:30542770 PMID:31433112 PMID:31838054 PMID:32602595 PMID:32877639 PMID:34612572 PMID:34859534 PMID:34897970 PMID:35901927 PMID:36343798 PMID:37934488 PMID:38336255 More...
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NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G
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Bcl2a1
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BCL2-related protein A1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of BCL2A1 mRNA]
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CTD |
PMID:16256798 |
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NCBI chr 8:98,596,806...98,604,890
Ensembl chr 8:89,716,914...89,724,998
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G
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Bcl2l1
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Bcl2-like 1
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multiple interactions decreases expression increases degradation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in increased expression of BCL2L1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BCL2L1 protein; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of BCL2L1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in decreased expression of BCL2L1 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BCL2L1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BCL2L1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in decreased expression of BCL2L1 protein]]
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CTD |
PMID:14762343 PMID:17293559 PMID:18789402 PMID:21173233 PMID:21821001 PMID:22046442 PMID:23201927 PMID:25895139 PMID:29054700 PMID:35901927 More...
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NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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G
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Bcl2l11
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Bcl2-like 11
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multiple interactions increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rebamipide results in decreased expression of BCL2L11 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased phosphorylation of BCL2L11 protein; Resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BCL2L11 protein alternative form] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol inhibits the reaction [Glucose results in increased expression of BCL2L11 protein]]
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CTD |
PMID:20856197 PMID:21179458 PMID:25471227 PMID:29054700 |
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NCBI chr 3:135,820,042...135,857,330
Ensembl chr 3:115,366,646...115,404,068
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G
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Bcr
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BCR activator of RhoGEF and GTPase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased chemical synthesis of Histamine]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]
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CTD |
PMID:16849647 |
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NCBI chr20:13,468,732...13,596,333
Ensembl chr20:13,471,668...13,597,016
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G
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Bdkrb1
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bradykinin receptor B1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1A protein results in increased expression of BDKRB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of BDKRB1 protein]
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CTD |
PMID:29775649 |
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NCBI chr 6:130,275,631...130,284,968
Ensembl chr 6:124,510,870...124,513,747
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G
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Bdnf
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brain-derived neurotrophic factor
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased expression of BDNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased chemical synthesis of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased expression of BDNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased secretion of BDNF protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
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CTD |
PMID:15287886 PMID:17172126 PMID:17209049 PMID:19962417 PMID:29061316 |
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NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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G
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Becn1
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beclin 1
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multiple interactions increases expression
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of BECN1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BECN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of BECN1 protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of BECN1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in increased expression of BECN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of BECN1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BECN1 protein
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CTD |
PMID:25955216 PMID:30726812 PMID:33450223 PMID:35568058 PMID:36343798 PMID:38729284 PMID:39067743 More...
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NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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G
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Bglap
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bone gamma-carboxyglutamate protein
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of BGLAP protein]]
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CTD |
PMID:33450223 |
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NCBI chr 2:176,136,341...176,137,318
Ensembl chr 2:173,838,518...173,839,495
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G
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Bid
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BH3 interacting domain death agonist
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased degradation of BID protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of and results in increased localization of BID protein]]
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CTD |
PMID:20856197 PMID:27032576 |
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NCBI chr 4:155,785,366...155,808,775
Ensembl chr 4:154,113,198...154,134,720
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G
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Birc2
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baculoviral IAP repeat-containing 2
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC2 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of BIRC2 mRNA]
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CTD |
PMID:12970779 PMID:14762343 PMID:15065019 PMID:16256798 PMID:19596284 |
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NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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G
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Birc3
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baculoviral IAP repeat-containing 3
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of BIRC3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC3 protein
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CTD |
PMID:12970779 PMID:14762343 PMID:15339911 PMID:19596284 |
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NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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G
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Birc5
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baculoviral IAP repeat-containing 5
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multiple interactions decreases expression increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in increased expression of BIRC5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [arsenic trioxide results in decreased expression of BIRC5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Simvastatin results in decreased expression of BIRC5 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of BIRC5 protein; Simvastatin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of BIRC5 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of BIRC5 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of BIRC5 mRNA]
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CTD |
PMID:15065019 PMID:16222118 PMID:17472962 PMID:17548900 PMID:18606715 PMID:19211844 PMID:20464445 PMID:20514400 PMID:21594580 PMID:22046442 More...
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NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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G
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Bmp2
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bone morphogenetic protein 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]]
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CTD |
PMID:18495116 |
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NCBI chr 3:141,264,648...141,275,416
Ensembl chr 3:120,812,882...120,821,397
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G
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Btc
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betacellulin
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein]
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CTD |
PMID:19105244 |
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NCBI chr14:16,992,668...17,031,178
Ensembl chr14:16,707,982...16,747,049
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G
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Calca
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calcitonin-related polypeptide alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in decreased susceptibility to Etoposide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CALCA protein results in increased expression of BIRC5 protein]
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CTD |
PMID:16222118 |
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NCBI chr 1:178,312,636...178,317,588
Ensembl chr 1:168,878,214...168,883,105
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G
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Camp
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cathelicidin antimicrobial peptide
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol promotes the reaction [Resveratrol results in increased expression of CAMP mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of CAMP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol promotes the reaction [Calcitriol results in increased expression of CAMP mRNA]]
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CTD |
PMID:24039193 |
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NCBI chr 8:109,841,729...109,843,543
Ensembl chr 8:109,841,729...109,843,543
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G
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Car9
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carbonic anhydrase 9
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]]
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CTD |
PMID:19808899 |
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NCBI chr 5:62,559,024...62,565,626
Ensembl chr 5:57,763,206...57,769,838
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G
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Casp1
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caspase 1
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multiple interactions increases cleavage
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased cleavage of CASP1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of CASP1 protein]] [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased cleavage of CASP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP1 protein
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CTD |
PMID:25929181 PMID:30726812 PMID:36898572 |
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NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G
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Casp2
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caspase 2
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]
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CTD |
PMID:19801490 |
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NCBI chr 4:71,149,632...71,167,388
Ensembl chr 4:71,149,669...71,167,379
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G
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Casp3
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caspase 3
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increases cleavage multiple interactions increases activity
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CASP3 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein inhibits the reaction [Glycochenodeoxycholic Acid results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg2 inhibits the reaction [APP protein modified form results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [morroniside inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin inhibits the reaction [[Oxygen deficiency co-treated with Oxygen] results in increased cleavage of and results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in decreased expression of CASP3 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodioloside inhibits the reaction [Colistin results in increased activity of and results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [APP protein modified form results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cadmium Chloride results in increased cleavage of CASP3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased expression of and results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutecarpine inhibits the reaction [tert-Butylhydroperoxide results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Paraquat results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in decreased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Carboplatin results in increased cleavage of and results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased activity of and results in increased localization of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of and results in increased activity of CASP3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Gemcitabine] affects the activity of CASP3 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein; [U 0126 co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [fenvalerate inhibits the reaction [[Cadmium Chloride results in increased abundance of Cadmium] which results in increased cleavage of CASP3 protein]]; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP3 protein]; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; Boc-D-FMK inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein]; pyrazolanthrone inhibits the reaction [[fludarabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased activity of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased activity of and results in increased cleavage of CASP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in increased cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin inhibits the reaction [trimethyltin results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein]; [Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased activity of CASP3 protein
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CTD |
PMID:14687664 PMID:14688022 PMID:15695173 PMID:15850772 PMID:15942663 PMID:16018989 PMID:16256798 PMID:16275998 PMID:16487511 PMID:17045724 PMID:17293559 PMID:17341418 PMID:17928571 PMID:19233221 PMID:19261616 PMID:19738051 PMID:19801490 PMID:19827268 PMID:20856197 PMID:23143138 PMID:23201927 PMID:23300732 PMID:23352507 PMID:23419388 PMID:24602480 PMID:25773745 PMID:25895139 PMID:26686574 PMID:27032576 PMID:28025122 PMID:28185818 PMID:28465020 PMID:28756148 PMID:28949029 PMID:29782821 PMID:30365941 PMID:30542770 PMID:31433112 PMID:31935362 PMID:32298737 PMID:32877639 PMID:32954801 PMID:33030052 PMID:33035517 PMID:33645131 PMID:33689844 PMID:34612572 PMID:34859534 PMID:34897970 PMID:36252918 PMID:36343798 PMID:37934488 PMID:38336255 More...
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NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G
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Casp4
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caspase 4
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]]
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CTD |
PMID:19801490 |
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NCBI chr 8:2,599,017...2,635,097
Ensembl chr 8:2,598,876...2,635,092
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G
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Casp6
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caspase 6
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP6 protein]
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CTD |
PMID:17341418 PMID:19801490 |
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NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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G
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Casp7
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caspase 7
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increases activity increases cleavage multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP7 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP7 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased activity of CASP7 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chlorpyrifos results in increased cleavage of CASP7 protein]
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CTD |
PMID:14687664 PMID:14688022 PMID:16487511 PMID:36252918 |
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NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G
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Casp8
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caspase 8
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multiple interactions increases activity
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased activity of CASP8 protein]; 3-(3-chloro-4-hydroxyphenylamino)-4-(4-nitrophenyl)-1H-pyrrole-2,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of CASP8 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP8 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [soybean oil, phospholipid emulsion inhibits the reaction [Amlodipine results in increased cleavage of CASP8 protein]]
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CTD |
PMID:15850772 PMID:15942663 PMID:20856197 PMID:27032576 PMID:33030052 |
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NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G
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Casp9
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caspase 9
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multiple interactions increases cleavage
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Indomethacin results in increased activity of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Pyruvaldehyde results in increased expression of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased activity of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oxygen deficiency results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [pachastrissamine analog results in increased cleavage of CASP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of CASP9 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP9 protein; BCL2 protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased cleavage of CASP9 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of CASP9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in increased cleavage of CASP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]]
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CTD |
PMID:12438947 PMID:15850772 PMID:16412023 PMID:17341418 PMID:19801490 PMID:20856197 PMID:26577515 PMID:32298737 PMID:32877639 PMID:33035517 PMID:34612572 PMID:34859534 PMID:34897970 PMID:35123989 PMID:38336255 More...
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Ensembl chr 5:154,109,046...154,126,626
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G
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Cat
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catalase
|
multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in decreased expression of CAT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in increased activity of CAT protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of CAT protein]
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CTD |
PMID:22040890 PMID:32602595 PMID:35901927 |
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NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
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G
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Ccl11
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C-C motif chemokine ligand 11
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]
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CTD |
PMID:11980903 |
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NCBI chr10:67,028,328...67,032,929
Ensembl chr10:67,028,328...67,032,926
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G
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Ccl2
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C-C motif chemokine ligand 2
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CCL2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cocaine results in increased expression of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of CCL2 protein]
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CTD |
PMID:16794257 PMID:19293636 PMID:19446813 PMID:20354174 PMID:22225513 PMID:24530660 PMID:25171655 More...
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G
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Ccl5
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C-C motif chemokine ligand 5
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
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CTD |
PMID:22225513 |
|
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G
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Ccn1
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cellular communication network factor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acetylcysteine results in increased expression of CCN1 protein]
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CTD |
PMID:21055460 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G
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Ccn2
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cellular communication network factor 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of CCN2 mRNA]]
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CTD |
PMID:26054450 PMID:33270355 |
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NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
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G
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Ccna2
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cyclin A2
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decreases expression multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNA2 protein [Oxygen deficiency co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of CCNA2 protein; [Oxygen deficiency co-treated with kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CCNA2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNA2 protein]
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CTD |
PMID:14971663 PMID:17148679 PMID:36940862 |
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NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G
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Ccnb1
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cyclin B1
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CCNB1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CCNB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNB1 mRNA
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CTD |
PMID:32877639 PMID:34677630 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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G
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Ccnd1
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cyclin D1
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multiple interactions decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of CCND1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sirolimus results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased expression of CCND1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in decreased expression of CCND1 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BTC protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CCND1 protein]; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CCND1 protein]
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CTD |
PMID:14750165 PMID:14757120 PMID:15695173 PMID:16412023 PMID:17148679 PMID:18353414 PMID:19105244 PMID:19661225 PMID:21179458 PMID:24231000 PMID:27312872 PMID:31499123 PMID:31758290 PMID:36940862 More...
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G
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Ccnd2
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cyclin D2
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multiple interactions decreases expression decreases methylation increases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased methylation of CCND2 promoter 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CCND2 mRNA
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CTD |
PMID:14745455 PMID:15601625 PMID:15778701 |
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NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495
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G
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Ccnd3
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cyclin D3
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCND3 protein
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CTD |
PMID:14757120 PMID:15601625 PMID:15778701 |
|
NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371
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G
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Ccne1
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cyclin E1
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of CCNE1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CCNE1 protein
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CTD |
PMID:14757120 PMID:14971663 PMID:15601625 |
|
NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G
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Ccr2
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C-C motif chemokine receptor 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of CCR2 protein]
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CTD |
PMID:26163174 |
|
NCBI chr 8:132,611,883...132,619,106
Ensembl chr 8:123,734,430...123,742,100
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G
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Cd274
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CD274 molecule
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decreases expression multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CD274 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CD274 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [nano-diamino-tetrac results in decreased expression of CD274 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [nano-diamino-tetrac results in decreased expression of CD274 protein]; nano-diamino-tetrac promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CD274 protein]
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CTD |
PMID:29960019 |
|
NCBI chr 1:236,526,215...236,549,956
Ensembl chr 1:227,116,649...227,134,450
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G
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Cd36
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CD36 molecule
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CD36 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]
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CTD |
PMID:19640849 PMID:25712622 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G
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Cd38
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CD38 molecule
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA]
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CTD |
PMID:22556157 |
|
NCBI chr14:67,172,062...67,212,328
Ensembl chr14:67,172,063...67,211,986
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G
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Cd44
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CD44 molecule
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of CD44 protein]]
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CTD |
PMID:33396024 |
|
NCBI chr 3:109,610,824...109,699,776
Ensembl chr 3:89,157,058...89,244,620
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G
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Cdc25c
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cell division cycle 25C
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CDC25C protein]
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CTD |
PMID:32877639 |
|
NCBI chr18:26,608,483...26,630,292
Ensembl chr18:26,335,834...26,356,185
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G
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Cdc6
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cell division cycle 6
|
multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzalkonium Compounds results in decreased expression of CDC6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cetylpyridinium results in decreased expression of CDC6 protein]
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CTD |
PMID:36725023 |
|
NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
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G
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Cdh1
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cadherin 1
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increases expression multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDH1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in decreased expression of CDH1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate affects the localization of CDH1 protein]
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CTD |
PMID:23921149 PMID:25118938 PMID:25656647 PMID:26089345 PMID:26363213 PMID:27856280 PMID:30609689 PMID:33396024 More...
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NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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G
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Cdh2
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cadherin 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]
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CTD |
PMID:24997338 PMID:30609689 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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G
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Cdk1
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cyclin-dependent kinase 1
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDK1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased expression of CDK1 protein]
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CTD |
PMID:32877639 PMID:34677630 |
|
NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G
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Cdk16
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cyclin-dependent kinase 16
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDK16 mRNA]
|
CTD |
PMID:12710931 |
|
NCBI chr X:4,046,330...4,057,825
Ensembl chr X:1,492,814...1,504,148
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G
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Cdk2
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cyclin dependent kinase 2
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of CDK2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK2 protein]
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CTD |
PMID:34896440 PMID:36940862 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G
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Cdk4
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cyclin-dependent kinase 4
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CDK4 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased expression of CDK4 protein]
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CTD |
PMID:27312872 PMID:36940862 |
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NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
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G
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Cdkn1a
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cyclin-dependent kinase inhibitor 1A
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increases expression multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased expression of and affects the localization of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Dexamethasone results in decreased stability of CDKN1A protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Resveratrol co-treated with Clofarabine] results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Arsenic Trioxide results in increased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cycloheximide results in decreased expression of CDKN1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in increased expression of CDKN1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased expression of CDKN1A protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1A protein
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CTD |
PMID:15001399 PMID:15695173 PMID:17148679 PMID:23146690 PMID:25791921 PMID:26687534 PMID:27312872 PMID:28940008 PMID:31499123 PMID:32877639 PMID:34677630 More...
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G
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Cdkn1b
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cyclin-dependent kinase inhibitor 1B
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multiple interactions increases expression
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ISO
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[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of CDKN1B mRNA; [resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of CDKN1B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CDKN1B protein
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CTD |
PMID:11322924 PMID:15601625 PMID:17148679 PMID:18622747 PMID:21179458 |
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NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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G
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Cdkn2a
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cyclin-dependent kinase inhibitor 2A
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2A mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:103,984,949...104,003,149
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G
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Cdkn2d
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cyclin dependent kinase inhibitor 2D
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of CDKN2D mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 8:19,831,874...19,834,640
Ensembl chr 8:19,831,866...19,834,674
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G
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Cdx2
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caudal type homeo box 2
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA]
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CTD |
PMID:15350541 |
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NCBI chr12:7,726,798...7,733,142
Ensembl chr12:7,726,798...7,733,142
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G
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Cebpa
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CCAAT/enhancer binding protein alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of CEBPA mRNA]
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CTD |
PMID:25712622 |
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NCBI chr 1:96,896,584...96,899,256
Ensembl chr 1:87,759,433...87,762,412
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G
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Cebpb
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CCAAT/enhancer binding protein beta
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of CEBPB mRNA]
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CTD |
PMID:25712622 |
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NCBI chr 3:176,817,005...176,818,436
Ensembl chr 3:156,397,052...156,399,473
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G
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Cflar
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CASP8 and FADD-like apoptosis regulator
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CFLAR protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CFLAR protein alternative form
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CTD |
PMID:12970779 PMID:16434995 PMID:21173233 |
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NCBI chr 9:67,679,502...67,747,226
Ensembl chr 9:60,185,452...60,237,034
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G
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Cftr
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CF transmembrane conductance regulator
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]
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CTD |
PMID:15563584 |
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NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756
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G
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Chrna7
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cholinergic receptor nicotinic alpha 7 subunit
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PNU-282987 binds to and results in increased activity of CHRNA7 protein] which results in decreased susceptibility to Okadaic Acid]
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CTD |
PMID:21715663 |
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NCBI chr 1:126,123,425...126,249,181
Ensembl chr 1:116,714,711...116,837,240
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G
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Chrnb2
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cholinergic receptor nicotinic beta 2 subunit
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[5-iodo-3-(2-azetidinylmethoxy)pyridine binds to and results in increased activity of CHRNB2 protein] which results in decreased susceptibility to Okadaic Acid]
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CTD |
PMID:21715663 |
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NCBI chr 2:175,181,402...175,189,619
Ensembl chr 2:175,181,402...175,189,619
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G
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Chuk
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component of inhibitor of nuclear factor kappa B kinase complex
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multiple interactions decreases phosphorylation
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CHUK protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of CHUK protein
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CTD |
PMID:18789402 PMID:20386985 |
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NCBI chr 1:252,908,748...252,944,273
Ensembl chr 1:242,959,760...242,995,065
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G
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Cldn1
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claudin 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN1 protein]
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CTD |
PMID:38142011 |
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NCBI chr11:87,926,376...87,941,533
Ensembl chr11:74,421,569...74,436,724
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G
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Cldn2
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claudin 2
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]
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CTD |
PMID:15350541 |
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NCBI chr X:108,248,383...108,258,847
Ensembl chr X:103,459,780...103,474,838
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G
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Cldn5
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claudin 5
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multiple interactions decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of CLDN5 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in decreased expression of CLDN5 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of CLDN5 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Sulfide results in decreased expression of CLDN5 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CLDN5 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL6 protein results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in decreased expression of CLDN5 protein]
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CTD |
PMID:20525806 PMID:24200059 PMID:26025059 PMID:28741371 PMID:32404561 |
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NCBI chr11:95,717,172...95,718,598
Ensembl chr11:82,211,475...82,214,992
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G
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Col1a1
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collagen type I alpha 1 chain
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of COL1A1 protein]
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CTD |
PMID:39353502 |
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NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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G
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Col1a2
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collagen type I alpha 2 chain
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of COL1A2 protein]
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CTD |
PMID:33895847 |
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NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
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G
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Col4a1
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collagen type IV alpha 1 chain
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of COL4A1 mRNA]]
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CTD |
PMID:33270355 |
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NCBI chr16:84,885,597...84,996,482
Ensembl chr16:78,183,533...78,294,412
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G
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Cox4i1
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cytochrome c oxidase subunit 4i1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of COX4I1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of COX4I1 protein]
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CTD |
PMID:24041027 |
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NCBI chr19:65,630,383...65,636,623
Ensembl chr19:48,721,199...48,727,921
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G
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Creb1
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cAMP responsive element binding protein 1
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multiple interactions decreases phosphorylation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Gallic Acid co-treated with gallocatechol co-treated with epigallocatechin gallate co-treated with epicatechin gallate] inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of CREB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased phosphorylation of CREB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KMUP 1 results in increased phosphorylation of CREB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of CREB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cilomilast promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rolipram promotes the reaction [Nitroprusside results in increased phosphorylation of CREB1 protein]]
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CTD |
PMID:18276108 PMID:19962417 PMID:25605016 PMID:29061316 |
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NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
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G
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Csf1
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colony stimulating factor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]
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CTD |
PMID:14502240 |
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NCBI chr 2:198,065,400...198,084,774
Ensembl chr 2:195,377,215...195,411,704
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G
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Csf2
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colony stimulating factor 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]
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CTD |
PMID:22315502 |
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NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
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G
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Ctf1
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cardiotrophin 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CTF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin K 3 results in increased expression of CTF1 protein]
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CTD |
PMID:16507596 |
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NCBI chr 1:191,758,512...191,771,259
Ensembl chr 1:182,328,090...182,333,335
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G
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Ctnnb1
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catenin beta 1
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multiple interactions decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of and results in increased activity of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in decreased phosphorylation of and results in increased activity of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in decreased phosphorylation of and results in increased activity of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in decreased phosphorylation of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased expression of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein]; [Tamoxifen co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] affects the localization of CTNNB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of CTNNB1 protein modified form 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased stability of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in decreased phosphorylation of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in decreased expression of and affects the localization of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of CTNNB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [sodium arsenite results in decreased expression of CTNNB1 protein]
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CTD |
PMID:19814765 PMID:20542495 PMID:22046442 PMID:22859221 PMID:22884995 PMID:23143138 PMID:23219847 PMID:26089345 PMID:31715269 PMID:31758290 PMID:34283317 More...
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G
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Ctsb
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cathepsin B
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of CTSB protein
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CTD |
PMID:12663669 |
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NCBI chr15:41,565,607...41,586,479
Ensembl chr15:37,389,629...37,410,500
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G
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Cxcl10
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C-X-C motif chemokine ligand 10
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of CXCL10 mRNA]]
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CTD |
PMID:25171655 |
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NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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G
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Cxcl2
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C-X-C motif chemokine ligand 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of CXCL2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of CXCL2 mRNA]
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CTD |
PMID:24449419 |
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NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
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G
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Cycs
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cytochrome c, somatic
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affects localization multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of CYCS protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Selenium inhibits the reaction [nickel sulfate results in increased expression of CYCS protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid inhibits the reaction [Oxygen deficiency results in increased expression of CYCS protein]]
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CTD |
PMID:15942663 PMID:32298737 PMID:34612572 |
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NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G
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Cyp19a1
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cytochrome P450, family 19, subfamily a, polypeptide 1
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of CYP19A1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of CYP19A1 protein]
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CTD |
PMID:20096755 PMID:20678559 PMID:28571770 |
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NCBI chr 8:63,449,148...63,476,534
Ensembl chr 8:54,553,165...54,580,758
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G
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Cyp1b1
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cytochrome P450, family 1, subfamily b, polypeptide 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dinoprostone results in increased expression of CYP1B1 protein]
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CTD |
PMID:20093341 |
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NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G
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Cyp2e1
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cytochrome P450, family 2, subfamily e, polypeptide 1
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increases expression
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of CYP2E1 mRNA
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CTD |
PMID:11306697 |
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NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
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G
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Dag1
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dystroglycan 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of DAG1 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 8:117,769,517...117,834,347
Ensembl chr 8:108,890,929...108,952,325
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G
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Dct
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dopachrome tautomerase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of DCT protein]
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CTD |
PMID:21816215 |
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NCBI chr15:101,469,159...101,508,029
Ensembl chr15:95,062,003...95,100,836
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G
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Dcx
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doublecortin
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DCX protein
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CTD |
PMID:29129800 |
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NCBI chr X:112,227,455...112,370,291
Ensembl chr X:107,430,767...107,507,476
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G
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Ddit3
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DNA-damage inducible transcript 3
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of DDIT3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of DDIT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of DDIT3 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of DDIT3 protein]
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CTD |
PMID:11145585 PMID:17171638 PMID:27658547 PMID:31433112 |
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NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
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G
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Ddit4
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DNA-damage-inducible transcript 4
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of DDIT4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of DDIT4 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DDIT4 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of DDIT4 protein
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CTD |
PMID:17307335 |
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NCBI chr20:28,434,938...28,437,037
Ensembl chr20:27,891,998...27,894,105
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G
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Dgkd
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diacylglycerol kinase, delta
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of DGKD protein alternative form]
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CTD |
PMID:22974639 |
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NCBI chr 9:88,516,686...88,607,349
Ensembl chr 9:88,516,715...88,607,345
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G
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Dlg4
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discs large MAGUK scaffold protein 4
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of DLG4]
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CTD |
PMID:26969072 |
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NCBI chr10:55,239,397...55,267,780
Ensembl chr10:54,739,470...54,767,153
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G
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Dnmt3b
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DNA methyltransferase 3 beta
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of DNMT3B protein]
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CTD |
PMID:26942697 |
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NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124
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G
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Dpp3
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dipeptidylpeptidase 3
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]
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CTD |
PMID:17360324 |
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NCBI chr 1:211,634,067...211,657,898
Ensembl chr 1:202,204,693...202,228,541
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G
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Dync1h1
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dynein cytoplasmic 1 heavy chain 1
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of DYNC1H1 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 6:135,436,375...135,502,117
Ensembl chr 6:129,609,397...129,680,883
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G
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E2f1
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E2F transcription factor 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased expression of E2F1 protein]
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CTD |
PMID:14971663 |
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NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
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G
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Edn1
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endothelin 1
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multiple interactions
|
EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]
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CTD |
PMID:12411397 |
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NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
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G
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Eef1a2
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eukaryotic translation elongation factor 1 alpha 2
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decreases expression multiple interactions increases expression
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of EEF1A2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of EEF1A2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of EEF1A2 protein
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CTD |
PMID:19738051 PMID:37051183 |
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NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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G
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Egf
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epidermal growth factor
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of and results in increased secretion of EGF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyadox results in increased expression of EGF]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of AR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of AQP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of EGF] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]
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CTD |
PMID:11742803 PMID:15040022 PMID:16343977 PMID:16472761 PMID:16619521 PMID:16848764 PMID:18214481 PMID:26109002 PMID:26470790 PMID:27087131 PMID:27634460 PMID:30265530 PMID:33325633 PMID:36343453 More...
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|
NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
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G
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Egfr
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epidermal growth factor receptor
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]
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CTD |
PMID:15177934 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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G
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Eif2a
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eukaryotic translation initiation factor 2A
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in decreased phosphorylation of EIF2A protein]
|
CTD |
PMID:27658547 |
|
NCBI chr 2:144,911,247...144,944,705
Ensembl chr 2:142,761,416...142,795,068
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G
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Eif4b
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eukaryotic translation initiation factor 4B
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of EIF4B protein]
|
CTD |
PMID:21268130 |
|
NCBI chr 7:133,206,637...133,228,436
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G
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Eif4e
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eukaryotic translation initiation factor 4E
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multiple interactions decreases phosphorylation
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of EIF4E protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4E protein
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CTD |
PMID:12781867 PMID:26282490 |
|
NCBI chr 2:229,736,309...229,772,628
Ensembl chr 2:227,066,673...227,098,683
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G
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Eif4ebp1
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eukaryotic translation initiation factor 4E binding protein 1
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multiple interactions decreases phosphorylation
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ISO EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of EIF4EBP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of EIF4EBP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of EIF4EBP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]
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CTD |
PMID:12411397 PMID:12569580 PMID:12939469 PMID:14769825 PMID:17148679 PMID:18622747 PMID:19478560 PMID:26282490 More...
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|
NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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G
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Eif4g1
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eukaryotic translation initiation factor 4 gamma 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of EIF4G1 protein]
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CTD |
PMID:12781867 |
|
NCBI chr11:93,726,322...93,746,387
Ensembl chr11:80,221,919...80,241,941
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G
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Eif4g2
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eukaryotic translation initiation factor 4, gamma 2
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increases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of EIF4G2 protein
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CTD |
PMID:18491231 |
|
NCBI chr 1:165,181,433...165,193,583
Ensembl chr 1:165,181,434...165,193,588
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G
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Ep300
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E1A binding protein p300
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein]
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CTD |
PMID:27094368 |
|
NCBI chr 7:114,987,857...115,058,652
Ensembl chr 7:113,106,247...113,136,088 Ensembl chr 7:113,106,247...113,136,088
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G
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Epas1
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endothelial PAS domain protein 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of EPAS1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of EPAS1 protein]
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CTD |
PMID:23958427 |
|
NCBI chr 6:13,543,252...13,626,147
Ensembl chr 6:7,790,647...7,871,228
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G
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Epo
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erythropoietin
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased susceptibility to Doxorubicin] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased abundance of Nitrites] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in decreased susceptibility to Levodopa]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO results in increased phosphorylation of GSK3B protein]
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CTD |
PMID:17928571 PMID:17952604 PMID:21683736 PMID:21915944 PMID:23384249 |
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NCBI chr12:24,841,285...24,844,725
Ensembl chr12:19,204,508...19,207,946
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G
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Erbb2
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erb-b2 receptor tyrosine kinase 2
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multiple interactions decreases expression
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Cisplatin]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Doxorubicin]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Etoposide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Fluorouracil]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Mitoxantrone]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in decreased susceptibility to Paclitaxel]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ERBB2 results in increased expression of ABCG2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of ERBB2 mRNA]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of ERBB2 mRNA]
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CTD |
PMID:12439862 PMID:21712253 PMID:30205135 |
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NCBI chr10:83,907,491...83,931,365
Ensembl chr10:83,411,313...83,435,078
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G
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Erbb3
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erb-b2 receptor tyrosine kinase 3
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [beta-hexachlorocyclohexane promotes the reaction [ERBB2 protein binds to ERBB3 protein]]
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CTD |
PMID:12439862 |
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NCBI chr 7:1,579,079...1,600,379
Ensembl chr 7:996,225...1,015,525
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G
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Ervfrd-1
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endogenous retrovirus group FRD member 1, envelope
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in decreased expression of ERVFRD-1 protein]
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CTD |
PMID:38180513 |
|
NCBI chr12:27,787,680...27,794,732
Ensembl chr12:22,151,211...22,158,264
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G
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Esr1
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estrogen receptor 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein affects the localization of ESR1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyhalothrin results in increased expression of ESR1]
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CTD |
PMID:15947004 PMID:19661335 PMID:26969072 |
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NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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G
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Esrrg
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estrogen-related receptor gamma
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of ESRRG protein]
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CTD |
PMID:27038254 |
|
NCBI chr13:99,167,656...99,788,016
Ensembl chr13:99,564,669...99,783,397
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G
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F11r
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F11 receptor
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in decreased expression of F11R protein]
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CTD |
PMID:20932985 |
|
NCBI chr13:86,406,229...86,429,819
Ensembl chr13:83,873,797...83,897,402
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G
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F2
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coagulation factor II, thrombin
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [F2 protein results in increased localization of Calcium]
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CTD |
PMID:19814731 |
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NCBI chr 3:98,051,958...98,065,246
Ensembl chr 3:77,596,198...77,609,486
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G
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F3
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coagulation factor III, tissue factor
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Crocidolite results in increased expression of F3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in decreased expression of F3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Histamine results in increased expression of F3]
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CTD |
PMID:15020266 PMID:15371228 PMID:16009787 |
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NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
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G
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Fabp1
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fatty acid binding protein 1
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FABP1 mRNA]
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CTD |
PMID:25712622 |
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NCBI chr 4:104,744,302...104,753,119
Ensembl chr 4:103,191,006...103,194,788
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G
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Fabp4
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fatty acid binding protein 4
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of FABP4 mRNA]
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CTD |
PMID:15659569 |
|
NCBI chr 2:93,488,251...93,492,961
Ensembl chr 2:91,580,885...91,585,578
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G
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Fam168a
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family with sequence similarity 168, member A
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]] which results in increased cleavage of PARP1 protein
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CTD |
PMID:23251525 |
|
NCBI chr 1:155,057,352...155,203,439
Ensembl chr 1:155,057,352...155,201,220
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G
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Fas
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Fas cell surface death receptor
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multiple interactions affects response to substance decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FAS protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the susceptibility to FAS protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FAS mRNA
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CTD |
PMID:16162944 PMID:20665104 PMID:27032576 PMID:31445927 |
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NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G
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Faslg
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Fas ligand
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased expression of FASLG protein]
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CTD |
PMID:27032576 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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G
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Fasn
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fatty acid synthase
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multiple interactions decreases expression
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of FASN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of FASN protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN mRNA]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FASN protein
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CTD |
PMID:30205135 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
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G
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Fbxo32
|
F-box protein 32
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decreases expression
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FBXO32 mRNA
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CTD |
PMID:21832246 |
|
NCBI chr 7:91,620,925...91,654,491
Ensembl chr 7:89,730,232...89,765,436
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G
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Fgf1
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fibroblast growth factor 1
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decreases activity multiple interactions
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ISO EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of FGF1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]
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CTD |
PMID:11742803 PMID:15121739 PMID:15695173 PMID:16325820 |
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NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
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G
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Fgf2
|
fibroblast growth factor 2
|
multiple interactions decreases expression
|
EXP ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FGF2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased expression of and results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sodium Chloride results in increased expression of FGF2 mRNA]
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CTD |
PMID:11742803 PMID:15631803 PMID:26800359 PMID:29129800 |
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NCBI chr 2:122,164,454...122,218,796
Ensembl chr 2:120,236,328...120,291,221
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G
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Fgf7
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fibroblast growth factor 7
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[FGF7 protein results in increased phosphorylation of AKT1 protein] which results in increased expression of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of FAS protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SCD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]
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CTD |
PMID:16162944 PMID:19661335 |
|
NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929
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G
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Flg
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filaggrin
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in decreased expression of FLG protein]
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CTD |
PMID:31884678 |
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NCBI chr 2:178,884,793...178,912,986
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G
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Fn1
|
fibronectin 1
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased expression of FN1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of FN1 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased expression of FN1 protein]
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CTD |
PMID:33270355 PMID:33895847 PMID:39353502 |
|
NCBI chr 9:80,645,507...80,714,200
Ensembl chr 9:73,196,044...73,264,678
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G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [FOS protein binds to BMP2 promoter]]
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CTD |
PMID:18495116 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G
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Fosl1
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FOS like 1, AP-1 transcription factor subunit
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decreases expression
|
ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FOSL1 protein
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CTD |
PMID:18606715 |
|
NCBI chr 1:212,183,885...212,192,391
Ensembl chr 1:202,754,529...202,764,930
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G
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Foxa1
|
forkhead box A1
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in decreased expression of FOXA1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of FOXA1 mRNA]
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CTD |
PMID:25712622 PMID:26363213 |
|
NCBI chr 6:75,099,907...75,136,534
Ensembl chr 6:75,103,503...75,136,188
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G
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Foxg1
|
forkhead box G1
|
decreases expression
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of FOXG1 protein
|
CTD |
PMID:29129800 |
|
NCBI chr 6:72,401,582...72,404,392
Ensembl chr 6:66,666,587...66,678,607
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G
|
Foxo1
|
forkhead box O1
|
multiple interactions
|
ISO EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dexamethasone inhibits the reaction [sodium bisulfide results in decreased phosphorylation of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in decreased localization of FOXO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of FOXO1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Hydrogen Peroxide] results in increased expression of FOXO1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [echinacoside inhibits the reaction [Dexamethasone results in increased expression of and results in decreased phosphorylation of FOXO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and affects the localization of FOXO1 protein
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CTD |
PMID:12438947 PMID:20181797 PMID:25171655 PMID:26385185 PMID:29248466 PMID:30265530 PMID:32404561 PMID:33450223 PMID:38336255 More...
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|
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
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G
|
Foxo3
|
forkhead box O3
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multiple interactions increases expression decreases phosphorylation
|
ISO EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of and results in increased activity of FOXO3 protein; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone affects the localization of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein affects the localization of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol affects the localization of FOXO3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of FOXO3 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of and results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Norepinephrine results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased phosphorylation of and affects the localization of FOXO3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of FOXO3 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of FOXO3 protein]
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CTD |
PMID:16179367 PMID:19168439 PMID:19211844 PMID:19293636 PMID:23099361 PMID:23159718 PMID:25471227 PMID:25644787 PMID:26470790 PMID:32370496 More...
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|
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
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G
|
Foxo4
|
forkhead box O4
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decreases phosphorylation multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of FOXO4 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in decreased phosphorylation of FOXO4 protein]
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CTD |
PMID:30726812 |
|
NCBI chr X:70,425,218...70,432,120
Ensembl chr X:66,385,558...66,392,115
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G
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Fshb
|
follicle stimulating hormone subunit beta
|
multiple interactions decreases activity
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein results in decreased activity of FSHB protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of FSHB protein
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CTD |
PMID:23254195 |
|
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
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|
G
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Fth1
|
ferritin heavy chain 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased expression of FTH1 mRNA]
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CTD |
PMID:23829535 |
|
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
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|
G
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Fyn
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FYN proto-oncogene, Src family tyrosine kinase
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased phosphorylation of FYN protein]
|
CTD |
PMID:20850416 |
|
NCBI chr20:44,322,635...44,514,498
Ensembl chr20:42,766,369...42,959,911
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G
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Gabpa
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GA binding protein transcription factor subunit alpha
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of GABPA protein]
|
CTD |
PMID:17179207 |
|
NCBI chr11:37,375,040...37,404,060
Ensembl chr11:23,888,815...23,917,605
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G
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Gbp1
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guanylate binding protein 1
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of GBP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]]
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CTD |
PMID:15994321 |
|
NCBI chr 2:231,398,136...231,432,773
Ensembl chr 2:231,398,163...231,432,131 Ensembl chr 2:231,398,163...231,432,131
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G
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Gclc
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glutamate-cysteine ligase, catalytic subunit
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multiple interactions decreases expression
|
EXP ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of GCLC mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLC protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLC mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLC mRNA]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLC mRNA
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CTD |
PMID:19073151 PMID:20399244 PMID:21469739 PMID:25773745 PMID:25895139 PMID:26577515 PMID:26686574 More...
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NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
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G
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Gclm
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glutamate cysteine ligase, modifier subunit
|
decreases expression multiple interactions decreases activity
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GCLM mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GCLM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GCLM mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin results in increased expression of GCLM mRNA]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of GCLM protein
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CTD |
PMID:16972261 PMID:19073151 PMID:25895139 PMID:26577515 PMID:26686574 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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G
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Gcm1
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glial cells missing transcription factor 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in decreased expression of GCM1 protein]
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CTD |
PMID:38180513 |
|
NCBI chr 8:87,805,993...87,819,229
Ensembl chr 8:78,925,687...78,938,924
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G
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Gdf11
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growth differentiation factor 11
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[Galactosamine co-treated with lipopolysaccharide, E coli O55-B5] affects the cleavage of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of PIK3R1 protein]]
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CTD |
PMID:37934488 |
|
NCBI chr 7:1,311,732...1,325,211
Ensembl chr 7:1,311,732...1,320,725
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G
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Gja1
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gap junction protein, alpha 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of GJA1 protein]
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CTD |
PMID:34896440 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
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G
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Gjb1
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gap junction protein, beta 1
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multiple interactions
|
EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein]
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CTD |
PMID:15350541 |
|
NCBI chr X:66,501,848...66,509,783
Ensembl chr X:66,501,820...66,509,925
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G
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Glb1
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galactosidase, beta 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fluorometholone inhibits the reaction [Glucose results in increased activity of GLB1 protein]]
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CTD |
PMID:35264022 |
|
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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G
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Gli1
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GLI family zinc finger 1
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GLI1 protein
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CTD |
PMID:25945059 |
|
NCBI chr 7:65,042,237...65,054,888
Ensembl chr 7:63,156,926...63,169,251
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G
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Gli2
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GLI family zinc finger 2
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multiple interactions
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ISO
|
[HSPA1A protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Formaldehyde] results in increased expression of GLI2 protein
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CTD |
PMID:30600586 |
|
NCBI chr13:32,499,678...32,716,418
Ensembl chr13:29,946,809...30,163,574
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G
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Gp1ba
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glycoprotein Ib platelet subunit alpha
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]
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CTD |
PMID:20523355 |
|
NCBI chr10:55,831,901...55,856,729
Ensembl chr10:55,352,899...55,356,774
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G
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Gper1
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G protein-coupled estrogen receptor 1
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multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of GPER1 protein]
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CTD |
PMID:22645130 PMID:33035625 |
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NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
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G
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Gpt
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glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased expression of GPT protein]]
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CTD |
PMID:37934488 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
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G
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Gpx1
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glutathione peroxidase 1
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multiple interactions increases expression
|
EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-iodohexadecanal results in decreased expression of GPX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [N(6)-cyclopentyladenosine results in increased expression of GPX1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Potassium Iodide] results in increased expression of GPX1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GPX1 mRNA
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CTD |
PMID:35901927 PMID:38013145 |
|
NCBI chr 8:117,905,462...117,906,588
Ensembl chr 8:109,026,905...109,028,024
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G
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Gpx4
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glutathione peroxidase 4
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of and results in decreased activity of GPX4 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Palmitic Acid results in decreased expression of and results in decreased activity of GPX4 protein]
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CTD |
PMID:38174997 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
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G
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Grn
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granulin precursor
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multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:21820214 |
|
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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G
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Gsdmd
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gasdermin D
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased cleavage of GSDMD protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of GSDMD mRNA]]
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CTD |
PMID:36094782 PMID:36898572 |
|
NCBI chr 7:107,542,489...107,547,051
Ensembl chr 7:107,542,083...107,547,055
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G
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Gsk3a
|
glycogen synthase kinase 3 alpha
|
decreases phosphorylation multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3A protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [resveratrol results in increased phosphorylation of GSK3A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3A protein
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CTD |
PMID:14750165 PMID:16179367 PMID:19661225 PMID:21821001 |
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NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
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G
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Gsk3b
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glycogen synthase kinase 3 beta
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increases activity decreases phosphorylation multiple interactions affects response to substance decreases response to substance
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased activity of GSK3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO protein results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Quercetin inhibits the reaction [Okadaic Acid affects the phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [5-aminoisoquinolinone inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin inhibits the reaction [sodium arsenite results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of and results in decreased activity of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EPO results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rg1 inhibits the reaction [Lipopolysaccharides results in decreased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside analog results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Memantine analog inhibits the reaction [Glutamic Acid results in decreased phosphorylation of and results in increased activity of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein; [kaempferol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Oxygen deficiency results in increased phosphorylation of GSK3B protein]; Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA1 protein results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DEFA2 protein results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Polychlorinated Biphenyls analog results in decreased expression of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Temozolomide results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [celastrol results in decreased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in decreased phosphorylation of and results in decreased activity of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in decreased phosphorylation of GSK3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in increased activity of GSK3B protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] which results in decreased susceptibility to Bleomycin; GSK3B mutant form inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; Tamoxifen promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of GSK3B protein] GSK3B mRNA affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one GSK3B results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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CTD |
PMID:14750165 PMID:15753396 PMID:15845746 PMID:15942663 PMID:16179367 PMID:17513037 PMID:17928571 PMID:17952604 PMID:19429264 PMID:19661225 PMID:19814765 PMID:20064577 PMID:20542495 PMID:20696143 PMID:21821001 PMID:21832246 PMID:22046442 PMID:23352507 PMID:24231000 PMID:24361488 PMID:24726523 PMID:26048653 PMID:26089345 PMID:26968795 PMID:27050422 PMID:27867098 PMID:29353218 PMID:29723552 PMID:31715269 PMID:31758290 PMID:32092300 PMID:32877639 PMID:34283317 PMID:34455488 PMID:34859534 PMID:34874107 PMID:35024177 PMID:36940862 PMID:37853848 More...
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NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G
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Gsr
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glutathione-disulfide reductase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSR protein]
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CTD |
PMID:26577515 PMID:26686574 |
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NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
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G
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Gss
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glutathione synthetase
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased expression of GSS mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GSS mRNA
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CTD |
PMID:19073151 |
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NCBI chr 3:144,047,849...144,078,197
Ensembl chr 3:144,047,850...144,078,198
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G
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Gsta1
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glutathione S-transferase alpha 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of GSTA1 mRNA]
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CTD |
PMID:15090468 |
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NCBI chr 9:31,199,887...31,216,606
Ensembl chr 9:23,703,477...23,720,121
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G
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Gsta2
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glutathione S-transferase alpha 2
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-tert-butylhydroquinone results in increased expression of GSTA2]
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CTD |
PMID:15357004 |
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NCBI chr 8:88,064,829...88,077,168
Ensembl chr 8:79,184,322...79,196,798
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G
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Gstm1
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glutathione S-transferase mu 1
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increases expression
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GSTM1 mRNA
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CTD |
PMID:22406437 |
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NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411
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G
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Gstp1
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glutathione S-transferase pi 1
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increases expression multiple interactions decreases expression
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GSTP1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of GSTP1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin inhibits the reaction [Oxidopamine results in decreased expression of GSTP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of GSTP1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of GSTP1 mRNA
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CTD |
PMID:22406437 PMID:25271104 PMID:26577515 |
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NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
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G
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Gypa
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glycophorin A
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in decreased expression of GYPA protein]
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CTD |
PMID:20523355 |
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NCBI chr19:27,450,304...27,465,940
Ensembl chr19:27,450,308...27,465,822
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G
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H2ax
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H2A.X variant histone
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]
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CTD |
PMID:34784199 |
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NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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G
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H3f4
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H3.4 histone, cluster member
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multiple interactions
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ISO
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[Butyrates co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased acetylation of H3F4 protein
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CTD |
PMID:16256798 |
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NCBI chr10:43,740,702...43,741,262
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G
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Hdc
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histidine decarboxylase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[BCR protein mutant form binds to ABL1 protein mutant form] which results in increased expression of HDC mRNA]
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CTD |
PMID:16849647 |
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NCBI chr 3:113,847,256...113,865,334
Ensembl chr 3:113,847,260...113,865,341
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G
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Hif1a
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hypoxia inducible factor 1 subunit alpha
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decreases activity multiple interactions increases expression decreases reaction decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of HIF1A protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Deferoxamine results in increased activity of TP53 protein] which results in increased ubiquitination of and results in increased degradation of and results in decreased expression of HIF1A protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of HIF1A protein LY294002 inhibits the reaction [estrogen increases expression of Hif1a mRNA] in rat uterus 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HIF1A protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF2 protein results in increased expression of and results in increased activity of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of HIF1A protein]
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CTD RGD |
PMID:11424089 PMID:14726529 PMID:15050414 PMID:15213310 PMID:15631803 PMID:16227395 PMID:16682453 PMID:17015263 PMID:17082639 PMID:17307335 PMID:18924134 PMID:19640849 PMID:19808899 PMID:19950214 PMID:20524035 PMID:21544845 PMID:21984483 PMID:23968725 PMID:26974319 PMID:34147605 PMID:34677630 PMID:34978009 PMID:35122754 PMID:17272396 More...
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RGD:152177689 |
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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G
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Hk2
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hexokinase 2
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HK2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of HK2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HK2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of HK2 protein]
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CTD |
PMID:34147605 PMID:35122754 |
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NCBI chr 4:116,792,258...116,841,275
Ensembl chr 4:115,234,509...115,283,530
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G
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Hmgb1
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high mobility group box 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of HMGB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of HMGB1 protein]
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CTD |
PMID:25929181 PMID:27616297 |
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NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G
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Hmox1
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heme oxygenase 1
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multiple interactions decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [swietenine affects the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2''-galloylhyperin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cinnamaldehyde results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide affects the expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hydrogen Peroxide results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [kahweol results in increased expression of and results in increased activity of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [pachastrissamine analog results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutacarpine results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rutacarpine results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sesquiterpenes analog results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin results in increased stability of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Cadmium Chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [surfactin peptide results in increased expression of HMOX1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [15-deoxyprostaglandin J2 results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[diallyl trisulfide co-treated with Glucose] results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium results in increased expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside analog results in increased expression of and results in increased activity of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens results in increased expression of and results in increased activity of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HMOX1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [caffeoylquinic acid analog results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Hemin results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lansoprazole results in increased activity of HMOX1 promoter]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [quinone results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein promotes the reaction [Glucose results in increased expression of HMOX1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triterpenes analog results in increased expression of HMOX1 protein]
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CTD |
PMID:14687664 PMID:15882976 PMID:16109301 PMID:17420286 PMID:18048804 PMID:18357586 PMID:19647727 PMID:19764090 PMID:19781563 PMID:20020468 PMID:20399244 PMID:20486211 PMID:20594940 PMID:20833156 PMID:20938987 PMID:21366594 PMID:21397656 PMID:21469739 PMID:21840424 PMID:22019695 PMID:22659318 PMID:23290930 PMID:23453443 PMID:23500011 PMID:23535287 PMID:23994249 PMID:24355171 PMID:24726523 PMID:25148906 PMID:25239868 PMID:25773745 PMID:26048653 PMID:26111761 PMID:26385185 PMID:26542248 PMID:26686574 PMID:28025122 PMID:28213291 PMID:29353218 PMID:30040983 PMID:30672058 PMID:30965051 PMID:31306736 PMID:32602595 PMID:33270355 PMID:33645131 PMID:34160118 PMID:34677630 PMID:35024177 PMID:35123989 PMID:36880193 More...
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G
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Hnf1a
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HNF1 homeobox A
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HNF1A protein results in increased expression of IL1B mRNA]
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CTD |
PMID:15350541 |
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NCBI chr12:47,299,171...47,333,457
Ensembl chr12:41,645,587...41,672,104
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G
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Hnf1b
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HNF1 homeobox B
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HNF1B mRNA
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CTD |
PMID:16288212 |
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NCBI chr10:68,735,894...68,789,888
Ensembl chr10:68,735,894...68,789,888
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G
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Hoxa1
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homeobox A1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vitamin A results in increased expression of HOXA1]
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CTD |
PMID:26820057 |
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NCBI chr 4:82,586,505...82,589,209
Ensembl chr 4:81,255,883...81,258,504
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G
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Hras
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HRas proto-oncogene, GTPase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of ATF6 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of HSPA5 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of AKT1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6KB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]
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CTD |
PMID:18829283 PMID:23877152 PMID:24898257 PMID:30619488 |
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NCBI chr 1:205,712,625...205,729,406
Ensembl chr 1:196,296,263...196,300,615
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G
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Hsf1
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heat shock transcription factor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [squamosamide results in increased expression of HSF1 protein modified form]
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CTD |
PMID:11424089 PMID:21295016 |
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NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011
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G
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Hspa1a
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heat shock protein family A (Hsp70) member 1A
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[HSPA1A protein co-treated with Formaldehyde] results in increased phosphorylation of AKT1 protein]; [HSPA1A protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Formaldehyde] results in increased expression of GLI2 protein
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CTD |
PMID:30600586 |
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NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
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G
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Hspa1b
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heat shock protein family A (Hsp70) member 1B
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CPG-oligonucleotide results in increased expression of HSPA1B protein]
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CTD |
PMID:17046822 |
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NCBI chr20:3,859,756...3,863,800
Ensembl chr20:3,856,006...3,873,240 Ensembl chr20:3,856,006...3,873,240
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G
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Hspa5
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heat shock protein family A (Hsp70) member 5
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Cadmium Chloride results in increased expression of HSPA5 protein]] [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased expression of HSPA5 protein
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CTD |
PMID:19428936 PMID:24898257 PMID:31433112 |
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NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G
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Hspb1
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heat shock protein family B (small) member 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of HSPB1 protein]
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CTD |
PMID:25373458 |
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NCBI chr12:26,430,640...26,432,301
Ensembl chr12:20,794,028...20,795,743
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G
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Hspb8
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heat shock protein family B (small) member 8
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of HSPB8 protein
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CTD |
PMID:21233418 |
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NCBI chr12:40,176,405...40,205,002
Ensembl chr12:40,176,532...40,191,185
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G
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Iapp
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islet amyloid polypeptide
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[rosiglitazone co-treated with IAPP protein] results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]]
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CTD |
PMID:16204373 |
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NCBI chr 4:176,968,097...176,975,363
Ensembl chr 4:175,237,115...175,242,920
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G
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Icam1
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intercellular adhesion molecule 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of ICAM1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of ICAM1 protein]
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CTD |
PMID:15994321 PMID:25876056 PMID:29329563 |
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NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G
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Ifng
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interferon gamma
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of GBP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of ICAM1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of RNF213 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of ICAM1 mRNA]]
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CTD |
PMID:15994321 PMID:16427044 PMID:26278786 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G
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Igf1
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insulin-like growth factor 1
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multiple interactions increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ascorbate-2-phosphate results in increased secretion of IGF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein affects the localization of ESR1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [sodium arsenite results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein promotes the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of GSK3B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in decreased susceptibility to 1-Methyl-4-phenylpyridinium]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of HIF1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; [IGF1 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of AKT1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein inhibits the reaction [Isoflurane results in decreased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of CCND1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of GPER1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of ascorbate-2-phosphate results in increased expression of IGF1 mRNA
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CTD |
PMID:12569580 PMID:14745455 PMID:15297429 PMID:15947004 PMID:16465378 PMID:16682453 PMID:18388193 PMID:19105244 PMID:19416266 PMID:19657059 PMID:20064577 PMID:25597859 PMID:26254549 PMID:33035625 PMID:37853848 More...
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NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
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G
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Igf2
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insulin-like growth factor 2
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multiple interactions decreases response to substance
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dan-shen root extract inhibits the reaction [IGF2 protein mutant form results in increased cleavage of and results in increased activity of CASP3 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to IGF2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]
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CTD |
PMID:23419388 PMID:24055520 |
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NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
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G
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Igfbp3
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insulin-like growth factor binding protein 3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of IGFBP3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of IGFBP3 protein]
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CTD |
PMID:12710931 PMID:16682453 |
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NCBI chr14:82,056,347...82,064,083
Ensembl chr14:82,056,347...82,064,083
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G
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Ikbkb
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inhibitor of nuclear factor kappa B kinase subunit beta
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of IKBKB protein]
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CTD |
PMID:18789402 |
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NCBI chr16:76,021,968...76,075,717
Ensembl chr16:69,319,554...69,373,250
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G
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Il17a
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interleukin 17A
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]
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CTD |
PMID:17982072 |
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NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
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G
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Il18
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interleukin 18
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increases expression multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of IL18 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased secretion of IL18 protein]] [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Benzo(a)pyrene] results in increased expression of IL18 protein
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CTD |
PMID:30726812 PMID:36094782 |
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NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
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G
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Il1a
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interleukin 1 alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1A protein results in increased expression of BDKRB1 protein]
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CTD |
PMID:29775649 |
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NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G
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Il1b
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interleukin 1 beta
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multiple interactions increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased expression of CCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased secretion of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL1B protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of IL1B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL1B protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CDX2 protein results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CLDN2 protein results in increased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [GJB1 protein results in decreased expression of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HNF1A protein results in increased expression of IL1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [OCLN protein results in increased phosphorylation of IL1B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased secretion of IL1B protein]]
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CTD |
PMID:15350541 PMID:16359550 PMID:19446813 PMID:25171655 PMID:25929181 PMID:26254549 PMID:26974319 PMID:30726812 PMID:31743544 PMID:32613688 PMID:34147605 PMID:36094782 PMID:36898572 PMID:38729284 PMID:39147216 More...
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NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G
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Il2
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interleukin 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND2 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased expression of CCND3 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]
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CTD |
PMID:15778701 |
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NCBI chr 2:121,932,968...121,937,672
Ensembl chr 2:120,004,862...120,009,566
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G
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Il4
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interleukin 4
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of FOXO3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased secretion of IL4 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased secretion of IL4 protein]
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CTD |
PMID:10611455 PMID:16179367 PMID:25929181 |
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NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G
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Il6
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interleukin 6
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL6 protein results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of IL6 mRNA]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of and results in increased secretion of IL6 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased expression of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased secretion of IL6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]
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CTD |
PMID:20600219 PMID:21131394 PMID:21474332 PMID:24530660 PMID:24631921 PMID:26025059 PMID:27295300 PMID:27664319 PMID:32613688 PMID:34147605 PMID:38729284 PMID:39147216 More...
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NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G
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Ins1
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insulin 1
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Anthraquinones co-treated with INS1 protein] affects the localization of SLC2A4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased uptake of Glucose]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR122 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR132 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR212 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:11306697 PMID:17962351 PMID:19052259 PMID:23920219 PMID:25543134 PMID:31071387 More...
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NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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G
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Ins2
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insulin 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in decreased susceptibility to sodium arsenite]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Quercetin] inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [triphenyl phosphate promotes the reaction [INS protein results in increased import of Glucose]]
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CTD |
PMID:17550345 PMID:18359480 PMID:25982963 PMID:26364587 PMID:28163246 |
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NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G
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Ip6k1
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inositol hexakisphosphate kinase 1
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decreases activity
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of IP6K1 protein
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CTD |
PMID:29042286 |
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NCBI chr 8:108,693,068...108,737,278
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G
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Irs1
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insulin receptor substrate 1
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decreases phosphorylation multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of IRS1 protein]
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CTD |
PMID:34455488 |
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NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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G
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Irs2
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insulin receptor substrate 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [IAPP protein promotes the reaction [rosiglitazone results in increased expression of IRS2 protein]]
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CTD |
PMID:16204373 |
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NCBI chr16:85,190,310...85,214,543
Ensembl chr16:78,485,045...78,512,482
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G
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Itga5
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integrin subunit alpha 5
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]
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CTD |
PMID:16465378 |
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NCBI chr 7:136,358,097...136,381,305
Ensembl chr 7:134,478,968...134,502,837
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G
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Itgam
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integrin subunit alpha M
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CCL11 protein results in increased expression of ITGAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased expression of ITGAM protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]
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CTD |
PMID:11980903 PMID:16617325 PMID:19176369 PMID:26254549 |
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NCBI chr 1:192,089,496...192,139,947
Ensembl chr 1:182,659,000...182,709,503
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G
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Itgav
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integrin subunit alpha V
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
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CTD |
PMID:15213856 |
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NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639
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G
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Itgb2
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integrin subunit beta 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]
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CTD |
PMID:16963453 |
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NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600
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G
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Itgb3
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integrin subunit beta 3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of and affects the localization of [ITGA5 protein binds to ITGB3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
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CTD |
PMID:15213856 PMID:16465378 |
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NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679
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G
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Jak2
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Janus kinase 2
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multiple interactions
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ISO
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LY294002 inhibits the reaction [cisplatin increases phosphorylation of Jak2 protein in kidney]
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RGD |
PMID:31250048 |
RGD:149735351 |
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
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G
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Jun
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Jun proto-oncogene, AP-1 transcription factor subunit
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multiple interactions decreases expression
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of JUN protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of JUN protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased phosphorylation of JUN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin promotes the reaction [JUN protein binds to BMP2 promoter]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased phosphorylation of JUN protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of JUN protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased phosphorylation of JUN protein
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CTD |
PMID:14687664 PMID:15850772 PMID:16018989 PMID:18495116 PMID:20338993 PMID:27087131 PMID:38477013 More...
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NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:109,893,145...109,897,656
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G
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Kit
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KIT proto-oncogene receptor tyrosine kinase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [KIT protein polymorphism results in increased expression of HMOX1 protein]
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CTD |
PMID:17420286 |
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NCBI chr14:32,901,615...32,978,895
Ensembl chr14:32,548,877...32,624,652
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G
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Kitlg
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KIT ligand
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]
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CTD |
PMID:21915944 |
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NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
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G
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Klf15
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KLF transcription factor 15
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine results in increased expression of KLF15 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-(4-(4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl)pyrrolidin-2-ylcarbonyl)thiazolidine results in increased expression of KLF15 protein]
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CTD |
PMID:32639145 |
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NCBI chr 4:124,522,652...124,535,613
Ensembl chr 4:122,965,807...122,978,374
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G
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Klf4
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KLF transcription factor 4
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of KLF4 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil affects the localization of KLF4 protein]
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CTD |
PMID:21484412 PMID:22685291 |
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NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G
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Klk1c10
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kallikrein 1-related peptidase C10
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of and results in decreased secretion of KLK3 protein]
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CTD |
PMID:16472761 |
|
NCBI chr 1:103,539,527...103,543,586
Ensembl chr 1:94,402,993...94,407,052
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G
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Ldha
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lactate dehydrogenase A
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of LDHA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LDHA protein
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CTD |
PMID:35122754 |
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NCBI chr 1:106,508,092...106,517,512
Ensembl chr 1:97,366,021...97,433,472
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G
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Lef1
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lymphoid enhancer binding factor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [loliolide results in increased expression of LEF1 mRNA]
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CTD |
PMID:31601058 |
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NCBI chr 2:222,340,541...222,453,931
Ensembl chr 2:219,666,592...219,779,794
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G
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Lep
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leptin
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decreases expression multiple interactions decreases secretion
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of LEP mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased phosphorylation of FOXO1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in increased expression of CYP19A1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of LEP protein
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CTD |
PMID:19254925 PMID:21351249 PMID:28571770 PMID:29248466 |
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NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G
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Lepr
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leptin receptor
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in decreased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in increased phosphorylation of FOXO3 protein]
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CTD |
PMID:23159718 |
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NCBI chr 5:121,409,735...121,593,201
Ensembl chr 5:116,289,823...116,475,908
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G
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Lgals3
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galectin 3
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multiple interactions decreases response to substance
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of and affects the localization of LGALS3 protein; 4-benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; Cycloheximide inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; Dactinomycin inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; GSK3B mutant form inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of LGALS3 protein]; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of BCL2L1 protein]; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein] LGALS3 results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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CTD |
PMID:21821001 |
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NCBI chr15:23,099,795...23,111,731
Ensembl chr15:20,607,692...20,632,025
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G
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Lhb
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luteinizing hormone subunit beta
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA]
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CTD |
PMID:23071612 |
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NCBI chr 1:105,037,457...105,038,446
Ensembl chr 1:95,900,984...95,901,972 Ensembl chr 1:95,900,984...95,901,972
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G
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Lhcgr
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luteinizing hormone/choriogonadotropin receptor
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHCGR protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:20610540 |
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NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
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G
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Lipa
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lipase A, lysosomal acid type
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of LIPA mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 1:241,437,524...241,470,936
Ensembl chr 1:232,024,356...232,057,633
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G
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Lpl
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lipoprotein lipase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of GBP1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LPL protein promotes the reaction [IFNG protein results in increased expression of ICAM1 mRNA]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of LPL mRNA]
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CTD |
PMID:15659569 PMID:15994321 |
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NCBI chr16:25,596,205...25,621,928
Ensembl chr16:20,829,465...20,855,249
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G
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M6pr
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mannose-6-phosphate receptor, cation dependent
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of M6PR mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 4:155,501,080...155,510,219
Ensembl chr 4:155,500,921...155,510,216
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G
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Malt1
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MALT1 paracaspase
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decreases activity
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MALT1 protein
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CTD |
PMID:21173233 |
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NCBI chr18:61,212,290...61,266,272
Ensembl chr18:58,942,299...58,994,260
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G
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Map1lc3a
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microtubule-associated protein 1 light chain 3 alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased expression of MAP1LC3A mRNA]
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CTD |
PMID:35568058 |
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NCBI chr 3:143,783,024...143,784,670
Ensembl chr 3:143,783,024...143,784,670
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G
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Map1lc3b
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microtubule-associated protein 1 light chain 3 beta
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multiple interactions increases lipidation increases cleavage
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [saikosaponin D results in decreased cleavage of MAP1LC3B protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [saikosaponin D results in increased expression of MAP1LC3B protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of MAP1LC3B protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of MAP1LC3B protein] [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with pachastrissamine analog] results in increased lipidation of MAP1LC3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased lipidation of MAP1LC3B protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of MAP1LC3B protein
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CTD |
PMID:30611790 PMID:35123989 PMID:38729284 |
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NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G
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Map2
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microtubule-associated protein 2
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MAP2 protein
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CTD |
PMID:29129800 |
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NCBI chr 9:75,173,038...75,431,606
Ensembl chr 9:67,723,371...67,979,809
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G
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Map2k1
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mitogen activated protein kinase kinase 1
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multiple interactions
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ISO EXP
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MAP2K1 protein inhibits the reaction [[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in increased cleavage of CASP3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased phosphorylation of EIF4EBP1 protein]
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CTD |
PMID:12411397 PMID:15850772 |
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NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:64,683,449...64,755,147
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G
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Map2k3
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mitogen activated protein kinase kinase 3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of MAP2K3 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr10:46,107,639...46,128,986
Ensembl chr10:45,607,163...45,629,492
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G
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Map3k1
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mitogen-activated protein kinase kinase kinase 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAP3K1 protein]
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CTD |
PMID:11306679 |
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NCBI chr 2:45,081,889...45,150,555
Ensembl chr 2:43,350,098...43,414,463
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G
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Mapk1
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mitogen activated protein kinase 1
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increases phosphorylation decreases phosphorylation multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of MAPK1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MAPK1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [epigallocatechin gallate results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ON123300 results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in decreased phosphorylation of MAPK1 protein; tamibarotene promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Antigen-Antibody Complex results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPK1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK1 protein
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CTD |
PMID:12834810 PMID:14757120 PMID:15020266 PMID:15072920 PMID:15177934 PMID:15287886 PMID:15339911 PMID:15531431 PMID:15850772 PMID:15919668 PMID:16179367 PMID:16211241 PMID:17172471 PMID:17293559 PMID:17341418 PMID:17931610 PMID:18295389 PMID:18388193 PMID:19038232 PMID:19139269 PMID:19233221 PMID:19477951 PMID:19561517 PMID:19881297 PMID:21474332 PMID:21984483 PMID:24568969 PMID:25203460 PMID:26089345 PMID:26109002 PMID:27032576 PMID:27286880 PMID:27431321 PMID:28185818 PMID:29702141 PMID:32298737 PMID:33618463 PMID:33771252 PMID:33921748 More...
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G
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Mapk10
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mitogen activated protein kinase 10
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased phosphorylation of MAPK10 protein]
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CTD |
PMID:21420390 |
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NCBI chr14:6,802,247...7,094,103
Ensembl chr14:6,497,707...6,786,201
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G
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Mapk3
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mitogen activated protein kinase 3
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increases phosphorylation multiple interactions decreases phosphorylation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of MAPK3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amentoflavone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [epigallocatechin gallate results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [euscaphic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Indomethacin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ON123300 results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Paclitaxel results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of and results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tormentic acid promotes the reaction [Oxygen deficiency results in increased phosphorylation of MAPK3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in decreased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with fludarabine] results in decreased phosphorylation of MAPK3 protein; tamibarotene promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of and results in decreased activity of MAPK3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MAPK3 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [etoxazole results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL4 protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased phosphorylation of MAPK3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-chloro-N(6)cyclopentyladenosine results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Antigen-Antibody Complex results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LY 379268 results in increased phosphorylation of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Sevoflurane results in increased phosphorylation of MAPK3 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tretinoin] results in decreased phosphorylation of MAPK3 protein
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CTD |
PMID:12834810 PMID:14757120 PMID:15020266 PMID:15072920 PMID:15177934 PMID:15287886 PMID:15339911 PMID:15531431 PMID:15850772 PMID:15919668 PMID:16179367 PMID:16211241 PMID:17172471 PMID:17293559 PMID:17341418 PMID:17931610 PMID:18295389 PMID:18388193 PMID:19038232 PMID:19139269 PMID:19233221 PMID:19477951 PMID:19561517 PMID:19881297 PMID:21474332 PMID:21984483 PMID:24568969 PMID:25203460 PMID:26089345 PMID:26109002 PMID:27032576 PMID:27286880 PMID:27431321 PMID:28185818 PMID:29702141 PMID:32298737 PMID:33618463 PMID:33771252 More...
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
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Mapk8
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mitogen-activated protein kinase 8
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Pt(O,O'-acac)(gamma-acac)(DMS) results in increased phosphorylation of MAPK8 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [flufenoxuron results in increased phosphorylation of MAPK8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased phosphorylation of MAPK8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased activity of MAPK8 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of MAPK8 protein
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CTD |
PMID:11306679 PMID:16018989 PMID:21420390 PMID:26385185 PMID:33771252 PMID:34160118 More...
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NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G
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Mapk9
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mitogen-activated protein kinase 9
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multiple interactions increases phosphorylation
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of and results in increased activity of MAPK9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased phosphorylation of MAPK9 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of MAPK9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of MAPK9 protein]
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CTD |
PMID:14688022 PMID:16018989 PMID:26385185 PMID:34160118 |
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NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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G
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Mapt
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microtubule-associated protein tau
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lithium Chloride inhibits the reaction [Okadaic Acid affects the phosphorylation of MAPT protein]]
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CTD |
PMID:27050422 |
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NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
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G
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Mcl1
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MCL1 apoptosis regulator, BCL2 family member
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multiple interactions decreases expression affects expression increases degradation
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ISO
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[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of MCL1 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Tamoxifen] results in decreased expression of MCL1 protein; LGALS3 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased degradation of MCL1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MCL1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the expression of MCL1 mRNA
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CTD |
PMID:17148679 PMID:20856197 PMID:21821001 PMID:22046442 PMID:23353698 |
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NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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G
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Mdm2
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MDM2 proto-oncogene
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increases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MDM2 protein
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CTD |
PMID:16412023 |
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NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
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G
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Mir122
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microRNA 122
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR122 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEP protein results in decreased expression of MIR122 mRNA]
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CTD |
PMID:23920219 PMID:29248466 |
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NCBI chr18:58,758,703...58,758,787
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G
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Mir132
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microRNA 132
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR132 mRNA]
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CTD |
PMID:23920219 |
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NCBI chr10:60,522,033...60,522,133
Ensembl chr10:60,023,696...60,023,796
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G
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Mir141
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microRNA 141
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP3 protein modified form]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Polyribonucleotides results in decreased expression of MIR141 mRNA] inhibits the reaction [Palmitic Acid results in increased expression of CASP9 protein modified form]]
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CTD |
PMID:34897970 |
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NCBI chr 4:157,523,239...157,523,332
Ensembl chr 4:157,523,239...157,523,332
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G
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Mir146a
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microRNA 146a
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein mutant form results in increased expression of MIR146A mRNA]
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CTD |
PMID:30619488 |
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NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610
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G
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Mir21
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microRNA 21
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[MIR21 mRNA results in decreased susceptibility to Cisplatin] which results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MIR21 mRNA results in decreased susceptibility to Cisplatin] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MIR21 mRNA
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CTD |
PMID:23272133 PMID:23466500 |
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NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
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G
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Mir212
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microRNA 212
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [INS1 protein results in increased expression of MIR212 mRNA]
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CTD |
PMID:23920219 |
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NCBI chr10:60,521,740...60,521,850
Ensembl chr10:60,023,403...60,023,513
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G
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Mitf
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melanocyte inducing transcription factor
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multiple interactions increases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of MITF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sweroside results in increased expression of MITF protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of MITF protein
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CTD |
PMID:21816215 PMID:26051519 |
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NCBI chr 4:131,965,676...132,177,790
Ensembl chr 4:130,409,217...130,621,145
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G
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Mki67
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marker of proliferation Ki-67
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT2 protein results in increased expression of MKI67 protein]
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CTD |
PMID:31838054 |
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NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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G
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Mmp1
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matrix metallopeptidase 1
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multiple interactions decreases expression decreases activity
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gadodiamide results in increased expression of MMP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of MMP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased expression of MMP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vehicle Emissions results in increased secretion of MMP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP1 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP1 protein
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CTD |
PMID:19393235 PMID:19561517 PMID:21245013 PMID:22326785 PMID:32613688 |
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NCBI chr 8:12,943,453...12,963,966
Ensembl chr 8:4,658,588...4,679,097
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G
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Mmp10
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matrix metallopeptidase 10
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP10 protein
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CTD |
PMID:24122885 |
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NCBI chr 8:4,689,840...4,697,748
Ensembl chr 8:4,689,840...4,697,748
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G
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Mmp12
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matrix metallopeptidase 12
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP12 mRNA]
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CTD |
PMID:16359550 PMID:16571779 |
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NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611
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G
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Mmp13
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matrix metallopeptidase 13
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Asbestos, Serpentine results in increased expression of MMP13 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Chloramphenicol results in increased expression of MMP13 mRNA]
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CTD |
PMID:16571779 PMID:20338993 |
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NCBI chr 8:4,497,960...4,508,239
Ensembl chr 8:4,497,960...4,508,239
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G
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Mmp14
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matrix metallopeptidase 14
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decreases expression decreases activity
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP14 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP14 protein
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CTD |
PMID:19393235 PMID:22326785 |
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NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864
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G
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Mmp2
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matrix metallopeptidase 2
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multiple interactions decreases expression decreases activity
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of MMP2] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP2 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of and results in increased activity of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein results in increased activity of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP2 protein
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CTD |
PMID:18805481 PMID:19393235 PMID:19956873 PMID:22326785 PMID:23566884 PMID:23877152 PMID:24997338 PMID:30609689 PMID:33325633 More...
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NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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G
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Mmp9
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matrix metallopeptidase 9
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multiple interactions decreases expression decreases activity
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Smoke analog results in increased secretion of MMP9 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Lipopolysaccharides results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP9 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of MMP9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP9 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MMP9 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,2',4,4'-tetrabromodiphenyl ether results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein inhibits the reaction [Berberine results in decreased activity of MMP9 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tetrabromobisphenol A results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butein results in decreased expression of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [leptin (116-130) results in decreased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Resveratrol results in increased expression of and results in increased activity of MMP9 protein]; [kahweol acetate co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of and results in increased activity of MMP9 protein]
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CTD |
PMID:17560598 PMID:18424783 PMID:19299917 PMID:19393235 PMID:19401153 PMID:19447859 PMID:19956873 PMID:19962414 PMID:20696233 PMID:22326785 PMID:23229870 PMID:23566884 PMID:24613819 PMID:24997338 PMID:25656647 PMID:25784559 PMID:25866363 PMID:26514923 PMID:27087131 PMID:27634460 PMID:30590137 PMID:30766661 PMID:31499123 PMID:33325633 PMID:34978009 More...
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NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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G
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Msmo1
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methylsterol monooxygenase 1
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decreases response to substance
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ISO
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MSMO1 protein results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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CTD |
PMID:23125191 |
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NCBI chr16:24,980,680...24,997,927
Ensembl chr16:24,980,697...24,998,016
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G
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Mt-co1
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mitochondrially encoded cytochrome c oxidase I
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased expression of COX1 protein]
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CTD |
PMID:30194976 |
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NCBI chr MT:5,323...6,867
Ensembl chr MT:5,323...6,867
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G
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Mt1
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metallothionein 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT1A mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
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CTD |
PMID:11551972 PMID:17363595 |
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NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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G
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Mt2
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metallothionein 2
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Zinc results in increased expression of MT2A mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT2A protein inhibits the reaction [Tunicamycin results in decreased phosphorylation of AKT1 protein]]
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CTD |
PMID:17363595 PMID:24680926 |
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NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
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G
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Mt3
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metallothionein 3
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multiple interactions decreases response to substance
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Doxorubicin]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MT3 protein results in decreased susceptibility to Hydrogen Peroxide] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to MT3 protein
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CTD |
PMID:19767621 |
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NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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G
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Mtor
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mechanistic target of rapamycin kinase
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multiple interactions decreases phosphorylation decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1,3-dichloro-2-propanol results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Lipopolysaccharides results in decreased expression of MTOR mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Estradiol] results in decreased phosphorylation of MTOR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Lipopolysaccharides results in increased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lupeol inhibits the reaction [[Vehicle Emissions results in increased abundance of Particulate Matter] which results in decreased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of MTOR mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased phosphorylation of MTOR protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MTOR protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of MTOR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MTOR protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Epirubicin results in increased phosphorylation of MTOR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased phosphorylation of MTOR protein]
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CTD |
PMID:17148679 PMID:17623046 PMID:19139269 PMID:23793038 PMID:26282490 PMID:29505745 PMID:31614463 PMID:32687844 PMID:33462182 PMID:33581215 PMID:33895847 PMID:34978009 PMID:35568058 PMID:36343798 PMID:37934488 PMID:38180513 PMID:38729284 PMID:39067743 More...
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NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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G
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Mtr
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5-methyltetrahydrofolate-homocysteine methyltransferase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dopamine results in increased activity of MTR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased activity of MTR protein]
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CTD |
PMID:14745455 |
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NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
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G
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Muc5ac
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mucin 5AC, oligomeric mucus/gel-forming
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of MUC5AC mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tobacco Smoke Pollution results in increased expression of MUC5AC protein]
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CTD |
PMID:21544845 PMID:34167450 |
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NCBI chr 1:196,864,336...196,896,475
Ensembl chr 1:196,864,336...196,896,475
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G
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Myc
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MYC proto-oncogene, bHLH transcription factor
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of MYC protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of MYC protein
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CTD |
PMID:35122754 |
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NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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G
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Mycn
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MYCN proto-oncogene, bHLH transcription factor
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]
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CTD |
PMID:12569580 |
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NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590
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G
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Myh4
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myosin heavy chain 4
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]
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CTD |
PMID:19657059 |
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NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295
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G
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Nanog
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Nanog homeobox
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multiple interactions decreases expression
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ISO
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[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of NANOG protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NANOG protein
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CTD |
PMID:23143138 |
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NCBI chr 4:157,615,687...157,623,061
Ensembl chr 4:155,943,737...155,951,116
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G
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Napa
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NSF attachment protein alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NAPA mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 1:76,787,036...76,805,869
Ensembl chr 1:76,786,932...76,805,869
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G
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Ndufb8
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NADH:ubiquinone oxidoreductase subunit B8
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NDUFB8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of NDUFB8 protein]
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CTD |
PMID:24041027 |
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NCBI chr 1:253,357,878...253,362,936
Ensembl chr 1:243,408,619...243,413,817
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G
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Nes
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nestin
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NES protein
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CTD |
PMID:29129800 |
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NCBI chr 2:175,735,715...175,745,631
Ensembl chr 2:173,438,734...173,447,777
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G
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Nfe2l2
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NFE2 like bZIP transcription factor 2
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decreases activity decreases expression multiple interactions increases expression
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of NFE2L2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NFE2L2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2''-galloylhyperin affects the localization of and results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[3-hydroxy-4-prenyl-5-methoxystilbene-2-carboxylic acid results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of and affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of NFE2L2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Docosahexaenoic Acids affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rb1 results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol affects the localization of and results in increased phosphorylation of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein modified form]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [shogaol metabolite affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spiraeoside inhibits the reaction [Glucose results in decreased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [swietenine promotes the reaction [Hydrogen Peroxide results in increased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [thymoquinone affects the localization of and results in increased activity of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ursodeoxycholic Acid results in increased localization of NFE2L2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with RTKI cpd] inhibits the reaction [Pyocyanine affects the localization of NFE2L2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [gypenoside analog affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ecdysterone promotes the reaction [1-Methyl-4-phenylpyridinium affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ginsenoside Rh4 inhibits the reaction [Alloxan affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [naringin affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxidopamine results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phytoestrogens affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Plant Extracts promotes the reaction [NFE2L2 protein binds to HMOX1 promoter]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [SMARCA4A protein affects the reaction [Glucose affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [caffeoylquinic acid analog results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in increased localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [farrerol affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate results in decreased expression of and affects the localization of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 results in increased expression of and affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rottlerin promotes the reaction [trimethyltin affects the localization of and results in increased activity of NFE2L2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triclosan results in increased expression of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triterpenes analog affects the localization of NFE2L2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Palmitic Acid results in decreased expression of NFE2L2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of NFE2L2 protein
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CTD |
PMID:17640564 PMID:18815141 PMID:19073151 PMID:19647727 PMID:19781563 PMID:20399244 PMID:20486211 PMID:21397656 PMID:21840424 PMID:22019695 PMID:22406437 PMID:23535287 PMID:23994249 PMID:24015256 PMID:24355171 PMID:24726523 PMID:25148906 PMID:25239868 PMID:25773745 PMID:25895139 PMID:26048653 PMID:26111761 PMID:26577515 PMID:26686574 PMID:28213291 PMID:28807874 PMID:29353218 PMID:29857117 PMID:30965051 PMID:32602595 PMID:33270355 PMID:33359794 PMID:33689844 PMID:34160118 PMID:34677630 PMID:35024177 PMID:36880193 PMID:38174997 More...
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NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G
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Nfkb1
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nuclear factor kappa B subunit 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin inhibits the reaction [IL1B protein results in increased activity of NFKB1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [NFKB1 protein binds to NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [REL protein binds to NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [RELA protein binds to NFKB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased activity of NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides affects the localization of NFKB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]
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CTD |
PMID:16256798 PMID:18006147 PMID:18207479 PMID:19446813 PMID:21173233 PMID:22974838 PMID:23268108 PMID:31068539 More...
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NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G
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Nfkbia
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NFKB inhibitor alpha
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased phosphorylation of NFKBIA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased phosphorylation of NFKBIA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased phosphorylation of NFKBIA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELA protein binds to NFKBIA promoter]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased phosphorylation of NFKBIA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of NFKBIA protein]
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CTD |
PMID:17172471 PMID:21173233 PMID:24085292 PMID:25271104 PMID:25656647 PMID:39147216 More...
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NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G
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Nfkbib
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NFKB inhibitor beta
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [oenothein B results in decreased phosphorylation of NFKBIB protein]
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CTD |
PMID:30452899 |
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NCBI chr 1:93,173,817...93,181,387
Ensembl chr 1:84,046,295...84,053,862
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G
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Ngf
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nerve growth factor
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multiple interactions decreases activity
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased expression of NGF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased expression of NGF protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of NGF protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF protein results in increased susceptibility to Capsaicin] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased localization of TRPV1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein]
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CTD |
PMID:12834810 PMID:16319926 PMID:17324588 PMID:21975456 |
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NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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G
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Nlrc5
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NLR family, CARD domain containing 5
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased expression of AKT1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased secretion of VEGFA protein]
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CTD |
PMID:27338800 |
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NCBI chr19:10,477,638...10,581,023
Ensembl chr19:10,477,628...10,562,121
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G
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Nlrp3
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NLR family, pyrin domain containing 3
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of NLRP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of NLRP3 protein]]
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CTD |
PMID:36094782 PMID:36898572 |
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NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
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G
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Nos2
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nitric oxide synthase 2
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decreases activity multiple interactions increases expression decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of NOS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of NOS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of NOS2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Manganese results in increased expression of NOS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NOS2 mRNA
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CTD |
PMID:10527657 PMID:16417967 PMID:17570326 PMID:23500011 PMID:23735482 PMID:24239652 PMID:24462917 PMID:24859013 PMID:25712622 PMID:26254549 PMID:27431321 PMID:30726812 More...
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NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G
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Nos3
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nitric oxide synthase 3
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Carbon Monoxide results in increased expression of ADIPOQ protein] which results in increased phosphorylation of NOS3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [(4-(((2-(3-fluoro-4-(trifluoromethyl)phenyl)-4-methyl-1,3-thiazol-5-yl)methyl)sulfanyl)-2-methylphenoxy)acetic acid results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-(3-(2-propyl-3-hydroxy-4-acetyl)phenoxy)propyloxyphenoxy acetic acid results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Cholesterol, HDL results in increased phosphorylation of and results in increased activity of AKT1 protein] which results in decreased degradation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[puerarin results in increased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein] which results in increased abundance of Nitric Oxide]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [amurensin G results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [anagliptin inhibits the reaction [Hydrogen Peroxide results in decreased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Atrazine results in decreased expression of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Digitoxin results in increased activity of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased expression of NOS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [propazine results in decreased expression of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [puerarin results in increased phosphorylation of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simazine results in decreased expression of NOS3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [terbutylazine results in decreased expression of NOS3 protein]
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CTD |
PMID:11788791 PMID:12821261 PMID:19356108 PMID:19446813 PMID:19616084 PMID:19767878 PMID:19906781 PMID:20562903 PMID:21884717 PMID:22314268 PMID:22982565 PMID:27431321 PMID:31586451 PMID:32044604 More...
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NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G
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Notch1
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notch receptor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased cleavage of NOTCH1 protein]
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CTD |
PMID:17513037 PMID:25118938 |
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NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
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G
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Nox1
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NADPH oxidase 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOX1 mRNA]
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CTD |
PMID:19293636 |
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NCBI chr X:101,572,338...101,625,571
Ensembl chr X:97,279,056...97,302,236
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G
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Nox4
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NADPH oxidase 4
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]
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CTD |
PMID:21131394 |
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NCBI chr 1:150,313,736...150,491,480
Ensembl chr 1:140,901,097...141,077,406
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G
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Nppa
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natriuretic peptide A
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increases expression multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of NPPA mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of NPPA mRNA]
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CTD |
PMID:32370496 |
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NCBI chr 5:163,712,184...163,713,493
Ensembl chr 5:158,429,042...158,430,351
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G
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Nqo1
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NAD(P)H quinone dehydrogenase 1
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multiple interactions decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[oxyphylla A co-treated with APP protein] results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [DPP3 protein results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of NQO1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of NQO1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [[gastrodin co-treated with rhyncophylline] affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NQO1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of NQO1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein promotes the reaction [Glucose results in increased expression of NQO1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sulforaphane results in increased expression of NQO1 protein]
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CTD |
PMID:15896333 PMID:17360324 PMID:26686574 PMID:29353218 PMID:33270355 PMID:33645131 PMID:35024177 More...
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NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
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G
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Nr0b2
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nuclear receptor subfamily 0, group B, member 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of NR0B2 mRNA]
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CTD |
PMID:25712622 |
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NCBI chr 5:145,779,294...145,782,609
Ensembl chr 5:145,779,294...145,782,609
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G
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Nr4a3
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nuclear receptor subfamily 4, group A, member 3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of NR4A3 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 5:67,157,141...67,198,287
Ensembl chr 5:62,361,822...62,402,733
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G
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Nrf1
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nuclear respiratory factor 1
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of NRF1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of NRF1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of NRF1 mRNA]
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CTD |
PMID:17179207 PMID:24041027 |
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NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
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G
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Nrg1
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neuregulin 1
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP10 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP5 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP6 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NRG1 protein inhibits the reaction [Doxorubicin results in increased activity of CASP9 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LHB protein results in decreased expression of NRG1 mRNA]
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CTD |
PMID:19801490 PMID:23071612 |
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NCBI chr16:65,954,084...67,007,484
Ensembl chr16:59,250,854...60,296,884
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G
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Nsdhl
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NAD(P) dependent 3-beta-hydroxysteroid dehydrogenase NSDHL
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decreases response to substance
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ISO
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NSDHL protein results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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CTD |
PMID:23125191 |
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NCBI chr X:150,775,034...150,807,161
Ensembl chr X:150,775,080...150,807,142
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G
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Ntf3
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neurotrophin 3
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decreases transport
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased transport of NTF3 protein
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CTD |
PMID:11948662 |
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NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
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G
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Ntf4
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neurotrophin 4
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decreases transport
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased transport of NTF4 protein
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CTD |
PMID:11948662 |
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NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:95,893,457...95,897,243
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G
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Ntrk1
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neurotrophic receptor tyrosine kinase 1
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multiple interactions increases phosphorylation
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ISO
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intybin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of NTRK1 protein]
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CTD |
PMID:28011163 |
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NCBI chr 2:175,534,844...175,551,664
Ensembl chr 2:173,236,963...173,253,770
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G
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Nts
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neurotensin
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
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CTD |
PMID:15177934 |
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NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
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G
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Nup153
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nucleoporin 153
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affects localization multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of NUP153 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP153 protein]
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CTD |
PMID:20041180 |
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NCBI chr17:17,972,217...18,024,876
Ensembl chr17:17,972,217...18,024,876
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G
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Nup88
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nucleoporin 88
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affects localization multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of NUP88 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [diethyl maleate affects the localization of NUP88 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one] affects the reaction [diethyl maleate affects the localization of NUP88 protein]
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CTD |
PMID:20041180 |
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NCBI chr10:55,667,903...55,692,249
Ensembl chr10:55,667,906...55,692,257
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G
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Ocln
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occludin
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multiple interactions affects localization
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [OCLN protein results in increased phosphorylation of IL1B protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of OCLN protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of OCLN protein]
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CTD |
PMID:15350541 PMID:19297429 PMID:24200059 |
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NCBI chr 2:33,391,303...33,442,207
Ensembl chr 2:31,657,220...31,764,150
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G
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Osgin1
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oxidative stress induced growth inhibitor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Docosahexaenoic Acids results in increased expression of OSGIN1 protein]
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CTD |
PMID:28807874 |
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NCBI chr19:47,471,750...47,500,517
Ensembl chr19:47,492,171...47,500,516
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G
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Park7
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Parkinsonism associated deglycase
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in decreased expression of PARK7 protein]
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CTD |
PMID:22245093 |
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NCBI chr 5:166,636,551...166,659,825
Ensembl chr 5:161,353,719...161,376,970
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G
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Parp1
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poly (ADP-ribose) polymerase 1
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multiple interactions increases cleavage
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Capsaicin results in increased cleavage of and results in increased activity of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Emodin results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [luteolin-7-glucoside results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Oligopeptides analog results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [pachastrissamine analog results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ZH-2 compound results in increased cleavage of PARP1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FAM168A results in decreased susceptibility to Cisplatin]] which results in increased cleavage of PARP1 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of PARP1 protein; arsenic disulfide promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased cleavage of PARP1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased cleavage of PARP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [CASP3 protein results in increased cleavage of PARP1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased cleavage of PARP1 protein]
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CTD |
PMID:14687664 PMID:14688022 PMID:16412023 PMID:19261616 PMID:20386985 PMID:22226932 PMID:23143138 PMID:23219847 PMID:23251525 PMID:24875536 PMID:27032576 PMID:27658547 PMID:30542770 PMID:32877639 PMID:33035517 PMID:34165247 PMID:35123989 More...
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NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
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G
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Pawr
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pro-apoptotic WT1 regulator
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PAWR mutant form results in decreased susceptibility to Cisplatin]
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CTD |
PMID:24144893 |
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NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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G
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Pcna
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proliferating cell nuclear antigen
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multiple interactions increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Tunicamycin co-treated with HRAS protein] results in increased expression of PCNA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with kaempferol] inhibits the reaction [Oxygen deficiency results in increased expression of PCNA protein] LY294002 inhibits the reaction [hypoxia increases expression of PCNA mRNA in rat pulmonary artery smooth muscle cells] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Trichloroethylene results in increased expression of PCNA protein]
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CTD RGD |
PMID:24898257 PMID:34896440 PMID:36940862 PMID:26485208 |
RGD:12910856 |
NCBI chr 3:139,951,948...139,955,820
Ensembl chr 3:119,498,810...119,502,995
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G
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Pdcd4
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programmed cell death 4
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multiple interactions increases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Tretinoin results in increased expression of PDCD4 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PDCD4 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PDCD4 protein
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CTD |
PMID:17259349 PMID:23272133 |
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NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275
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G
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Pdgfb
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platelet derived growth factor subunit B
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[PDGFB protein binds to PDGFB protein] which results in increased phosphorylation of AKT1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to [PDGFB protein binds to PDGFB protein]; U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]]
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CTD |
PMID:15919668 PMID:23457620 PMID:23958495 |
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NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
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G
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Pdk1
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pyruvate dehydrogenase kinase 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of [PDK1 protein binds to AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of AKT1 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] results in decreased susceptibility to [Paclitaxel co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one]; [PDK1 protein binds to AKT1 protein] which results in decreased susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one
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CTD |
PMID:20361045 |
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NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038
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G
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Pdx1
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pancreatic and duodenal homeobox 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose affects the localization of PDX1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]
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CTD |
PMID:9873045 |
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NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
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G
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Phb1
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prohibitin 1
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multiple interactions increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein inhibits the reaction [FSHB protein results in increased secretion of Estradiol]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [PHB1 protein results in decreased activity of FSHB protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PHB1 protein
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CTD |
PMID:23254195 |
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NCBI chr10:80,605,268...80,618,043
Ensembl chr10:80,605,251...80,618,042
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G
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Pik3ca
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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
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decreases activity increases expression multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CA protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PIK3CA mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of PIK3CA mRNA]
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CTD |
PMID:16179367 PMID:23793038 PMID:31522336 |
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NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
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G
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Pik3cb
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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
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decreases activity multiple interactions decreases expression increases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CB protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of PIK3CB protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog results in decreased expression of PIK3CB protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of PIK3CB protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with forsythiaside] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of PIK3CB protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PIK3CB mRNA
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CTD |
PMID:16179367 PMID:31522336 PMID:35122754 PMID:38729284 |
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NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663
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G
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Pik3cd
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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
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decreases activity multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CD protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3CD mRNA
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CTD |
PMID:16179367 PMID:31522336 |
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NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930
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G
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Pik3cg
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phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
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multiple interactions decreases expression decreases activity
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of and results in increased activity of PIK3CG protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of PIK3CG mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3CG mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of PIK3CG protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CG mRNA]
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CTD |
PMID:15020266 PMID:15178407 PMID:16179367 PMID:16794257 PMID:31522336 |
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NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
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G
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Pik3r1
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phosphoinositide-3-kinase regulatory subunit 1
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [27-hydroxycholesterol results in increased phosphorylation of PIK3R1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased phosphorylation of PIK3R1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nickel monoxide analog results in increased phosphorylation of PIK3R1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [GDF11 protein affects the reaction [[lipopolysaccharide, E coli O55-B5 co-treated with Galactosamine] results in increased phosphorylation of PIK3R1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Silicon Dioxide results in increased abundance of Silicon] which results in increased phosphorylation of PIK3R1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Melatonin inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [[nickel chloride results in increased abundance of Nickel] which results in decreased expression of PIK3R1 mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIK3R1 protein modified form
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CTD |
PMID:30911355 PMID:32044604 PMID:33895847 PMID:35568058 PMID:37934488 PMID:38180513 PMID:39353502 More...
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NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
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G
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Pim1
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Pim-1 proto-oncogene, serine/threonine kinase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of PIM1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Glucose results in decreased expression of PIM1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of PIM1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol inhibits the reaction [Hydrogen Peroxide results in decreased expression of PIM1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of PIM1 mRNA]; [Resveratrol co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of PIM1 protein
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CTD |
PMID:27049278 |
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NCBI chr20:7,556,496...7,560,747
Ensembl chr20:7,554,921...7,559,174
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G
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Pin1
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peptidylprolyl cis/trans isomerase, NIMA-interacting 1
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PIN1 protein
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CTD |
PMID:20804812 |
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NCBI chr 8:19,189,408...19,200,785
Ensembl chr 8:19,189,373...19,200,785
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G
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Pkm
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pyruvate kinase M1/2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of PKM mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of PKM protein]
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CTD |
PMID:34147605 |
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NCBI chr 8:68,949,731...68,975,394
Ensembl chr 8:60,057,402...60,079,599
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G
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Plau
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plasminogen activator, urokinase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [hispolon results in decreased expression of and results in decreased activity of PLAU protein]
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CTD |
PMID:27037602 |
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NCBI chr15:3,505,485...3,511,987
Ensembl chr15:3,456,232...3,462,775
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G
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Pmaip1
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phorbol-12-myristate-13-acetate-induced protein 1
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multiple interactions
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ISO
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[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in increased expression of PMAIP1 protein
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CTD |
PMID:20856197 |
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NCBI chr18:62,255,970...62,262,384
Ensembl chr18:59,986,017...59,992,429
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G
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Postn
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periostin
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of POSTN mRNA]
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CTD |
PMID:15121739 PMID:16325820 |
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NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
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G
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Pou5f1
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POU class 5 homeobox 1
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multiple interactions decreases expression
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ISO
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[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of POU5F1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of POU5F1 protein
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CTD |
PMID:23143138 |
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NCBI chr20:3,227,836...3,232,598
Ensembl chr20:3,223,129...3,227,891
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G
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Ppara
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peroxisome proliferator activated receptor alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of PPARA mRNA]
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CTD |
PMID:25712622 |
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NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
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G
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Pparg
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peroxisome proliferator-activated receptor gamma
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increases expression
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPARG mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPARG protein
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CTD |
PMID:17372590 |
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NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
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G
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Ppargc1a
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PPARG coactivator 1 alpha
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of PPARGC1A protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide promotes the reaction [NRF1 protein binds to PPARGC1A protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of PPARGC1A protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of PPARGC1A mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of PPARGC1A mRNA]
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CTD |
PMID:17179207 PMID:24041027 PMID:30194976 |
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NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
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G
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Ppid
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peptidylprolyl isomerase D
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multiple interactions increases expression
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EXP
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Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PPID protein]
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CTD |
PMID:34455488 |
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NCBI chr 2:167,025,985...167,037,998
Ensembl chr 2:164,727,779...164,740,221
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G
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Ppif
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peptidylprolyl isomerase F
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPIF mRNA]
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CTD |
PMID:12710931 |
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NCBI chr16:1,257,197...1,263,919
Ensembl chr16:1,257,106...1,263,913
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G
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Ppp1r1b
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protein phosphatase 1, regulatory (inhibitor) subunit 1B
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
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CTD |
PMID:17209049 |
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NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775
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G
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Ppp2r2b
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protein phosphatase 2, regulatory subunit B, beta
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PPP2R2B mRNA]
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CTD |
PMID:12710931 |
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NCBI chr18:34,904,686...35,357,299
Ensembl chr18:34,653,721...35,081,025
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G
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Prkcd
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protein kinase C, delta
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multiple interactions decreases phosphorylation affects localization
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]; sodium arsenite promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of PRKCD protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of PRKCD protein
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CTD |
PMID:11424089 PMID:17171638 PMID:20082316 |
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NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352
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G
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Prkcz
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protein kinase C, zeta
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decreases phosphorylation affects localization
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of PRKCZ protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of PRKCZ protein
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CTD |
PMID:12970779 PMID:15735031 |
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NCBI chr 5:171,101,774...171,212,694
Ensembl chr 5:165,819,466...165,930,367
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G
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Pten
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phosphatase and tensin homolog
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multiple interactions affects response to substance increases expression
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ISO EXP
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[decitabine co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Sirolimus] results in increased expression of PTEN mRNA; PTEN protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of CA9 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of CA9 protein]] PTEN protein affects the susceptibility to 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PTEN mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Gefitinib results in increased expression of PTEN mRNA]
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CTD |
PMID:18622747 PMID:19808899 PMID:32370496 PMID:33256086 |
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NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
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G
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Ptgs2
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prostaglandin-endoperoxide synthase 2
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multiple interactions increases expression decreases expression
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of PTGS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of PTGS2 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel sulfate co-treated with macrophage stimulatory lipopeptide 2] results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cholesterol-3-beta,5-alpha, 6-beta-triol results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [manganese chloride results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [monomethylarsonous acid results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Zinc results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-bromopropane results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cadmium sulfate results in increased expression of PTGS2]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Endosulfan results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Humic Substances results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipoteichoic acid results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [nonylphenol results in increased expression of PTGS2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of PTGS2 protein]
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CTD |
PMID:14687664 PMID:15980035 PMID:17084486 PMID:17093206 PMID:18840457 PMID:19084589 PMID:19616084 PMID:20377179 PMID:20600219 PMID:20954072 PMID:22353212 PMID:23500011 PMID:23968725 PMID:24239652 PMID:24449419 PMID:24530660 PMID:24859013 PMID:25199686 PMID:28495310 PMID:29894800 PMID:30726812 PMID:31068539 PMID:31884678 More...
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NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
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G
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Ptk2
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protein tyrosine kinase 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of PTK2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTK2 protein promotes the reaction [Doxorubicin results in increased phosphorylation of AKT1 protein]]
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CTD |
PMID:16168102 PMID:26109002 |
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NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
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G
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Ptpn1
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protein tyrosine phosphatase, non-receptor type 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of PTPN1 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 3:177,056,588...177,106,424
Ensembl chr 3:156,638,769...156,687,504
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G
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Ptpn11
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protein tyrosine phosphatase, non-receptor type 11
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PTPN11 protein mutant form results in increased susceptibility to CSF2 protein]
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CTD |
PMID:22315502 |
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NCBI chr12:41,026,079...41,085,577
Ensembl chr12:35,383,144...35,424,925
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G
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Ptpn5
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protein tyrosine phosphatase, non-receptor type 5
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Isoproterenol results in increased expression of PTPN5 protein]
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CTD |
PMID:17623046 |
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NCBI chr 1:106,756,896...106,817,369
Ensembl chr 1:97,620,642...97,679,882
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G
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Pycard
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PYD and CARD domain containing
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [peiminine inhibits the reaction [Particulate Matter results in increased expression of PYCARD protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium bisulfide inhibits the reaction [uranyl acetate results in increased expression of PYCARD protein]]
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CTD |
PMID:36094782 PMID:36898572 |
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NCBI chr 1:192,032,124...192,033,419
Ensembl chr 1:182,601,174...182,602,955
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G
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Rab32
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RAB32, member RAS oncogene family
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of RAB32 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 1:4,946,193...4,961,003
Ensembl chr 1:4,945,036...4,960,934
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G
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Rad23b
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RAD23 homolog B, nucleotide excision repair protein
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]
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CTD |
PMID:21742020 |
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NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319
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G
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Raf1
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Raf-1 proto-oncogene, serine/threonine kinase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dronabinol results in increased localization of RAF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methanandamide results in increased localization of RAF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phosphates results in increased phosphorylation of RAF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [ON123300 results in increased phosphorylation of RAF1 protein]
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CTD |
PMID:12834810 PMID:16763222 PMID:24568969 |
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NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
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G
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Rap1a
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RAP1A, member of RAS oncogene family
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]
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CTD |
PMID:16963453 |
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NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501
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G
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Rb1
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RB transcriptional corepressor 1
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multiple interactions decreases phosphorylation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RB1 protein [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [IL2 protein results in increased phosphorylation of RB1 protein]
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CTD |
PMID:14971663 PMID:15601625 PMID:15778701 PMID:18353414 |
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NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
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G
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Rbl1
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RB transcriptional corepressor like 1
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of RBL1 protein
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CTD |
PMID:15601625 |
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NCBI chr 3:145,806,160...145,869,434
Ensembl chr 3:145,807,095...145,869,330
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G
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Rel
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REL proto-oncogene, NF-kB subunit
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [REL protein binds to NFKB1 protein]
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CTD |
PMID:21173233 |
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NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
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G
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Rela
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RELA proto-oncogene, NF-kB subunit
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multiple interactions decreases expression affects localization
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[NFKB1 protein binds to RELA protein] which results in increased expression of ABCB1B mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased activity of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal inhibits the reaction [Lipopolysaccharides results in increased expression of RELA protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased expression of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetrachlorodibenzodioxin affects the localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased expression of RELA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of RELA protein modified form 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide affects the localization of RELA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the localization of RELA protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol affects the localization of and results in increased activity of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELA protein binds to NFKBIA promoter]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin affects the localization of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [titanium dioxide results in increased expression of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [morusin results in decreased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [oenothein B results in decreased phosphorylation of RELA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of [RELA protein binds to NFKB1 protein]
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CTD |
PMID:16256798 PMID:17982072 PMID:18006147 PMID:18207479 PMID:18295389 PMID:20386985 PMID:21173233 PMID:22003094 PMID:22974838 PMID:23268108 PMID:24530660 PMID:25271104 PMID:25656647 PMID:27087131 PMID:27634460 PMID:27664319 PMID:28302560 PMID:30452899 PMID:30911355 PMID:31068539 PMID:33035517 PMID:34874107 PMID:36343453 PMID:39147216 More...
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NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G
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Reln
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reelin
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [RELN protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:24876378 |
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NCBI chr 4:13,628,440...14,055,201
Ensembl chr 4:12,736,130...13,162,211
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G
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Rhoa
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ras homolog family member A
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased activity of RHOA protein]
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CTD |
PMID:22031849 |
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NCBI chr 8:117,870,548...117,904,303
Ensembl chr 8:108,991,954...109,025,746
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G
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Rnf213
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ring finger protein 213
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in increased expression of RNF213 mRNA]
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CTD |
PMID:26278786 |
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NCBI chr10:104,656,329...104,755,669
Ensembl chr10:104,656,883...104,757,918
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G
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Rps6
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ribosomal protein S6
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multiple interactions decreases phosphorylation
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IL2 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butylparaben results in decreased phosphorylation of RPS6 protein]; [PDK1 protein binds to AKT1 protein] inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CSF1 protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6 protein
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CTD |
PMID:12939469 PMID:14502240 PMID:15297429 PMID:15778701 PMID:16412023 PMID:17148679 PMID:17606477 PMID:19478560 PMID:20361045 PMID:24898257 PMID:29319206 More...
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NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
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G
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Rps6ka1
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ribosomal protein S6 kinase A1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KA1 protein]
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CTD |
PMID:33771252 |
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NCBI chr 5:151,362,819...151,402,064
Ensembl chr 5:146,079,021...146,118,272
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G
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Rps6kb1
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ribosomal protein S6 kinase B1
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decreases phosphorylation decreases expression multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased phosphorylation of RPS6KB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of RPS6KB1 protein modified form 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [flufenoxuron results in decreased phosphorylation of RPS6KB1 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with HRAS protein] results in decreased phosphorylation of RPS6KB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of RPS6KB1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [oxophenylarsine results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [butylparaben results in decreased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [quinocetone results in decreased phosphorylation of RPS6KB1 protein]; [Sirolimus co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased phosphorylation of RPS6KB1 protein; U 0126 promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [PDGFB protein results in increased phosphorylation of and results in increased activity of RPS6KB1 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EDN1 protein results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lysophosphatidic acid results in increased phosphorylation of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [MAP2K1 protein results in increased activity of RPS6KB1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phenylephrine results in increased activity of RPS6KB1 protein]
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CTD |
PMID:12411397 PMID:14516795 PMID:14769825 PMID:15297429 PMID:15919668 PMID:16179367 PMID:16183647 PMID:18622747 PMID:21976531 PMID:21984483 PMID:23255002 PMID:23793038 PMID:24898257 PMID:26506538 PMID:27098396 PMID:27542212 PMID:29319206 PMID:31614463 PMID:33771252 More...
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NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
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G
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Rrm2
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ribonucleotide reductase regulatory subunit M2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased expression of RRM2 mRNA]
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CTD |
PMID:22403396 |
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NCBI chr 6:47,044,755...47,075,370
Ensembl chr 6:41,340,557...41,346,773
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G
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Runx2
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RUNX family transcription factor 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol inhibits the reaction [Glucose results in decreased expression of RUNX2 protein]]
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CTD |
PMID:33450223 |
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NCBI chr 9:23,661,278...23,990,248
Ensembl chr 9:16,167,482...16,492,167
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G
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Scarb2
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scavenger receptor class B, member 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SCARB2 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr14:15,558,271...15,609,813
Ensembl chr14:15,558,236...15,609,813
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G
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Scd
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stearoyl-CoA desaturase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SCD protein]
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CTD |
PMID:16162944 |
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NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
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G
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Sec23a
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Sec23 homolog A, COPII coat complex component
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of SEC23A mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 6:76,658,793...76,706,125
Ensembl chr 6:76,658,427...76,706,035
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G
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Sftpc
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surfactant protein C
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SFTPC protein
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CTD |
PMID:15695173 |
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NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777
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G
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Sirpa
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signal-regulatory protein alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
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CTD |
PMID:12805067 |
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NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:116,819,726...116,858,098
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G
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Sirt1
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sirtuin 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [deoxynivalenol results in increased expression of SIRT1 mRNA]
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CTD |
PMID:34677630 |
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NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
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G
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Sirt6
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sirtuin 6
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRT6 protein affects the phosphorylation of EP300 protein]
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CTD |
PMID:27094368 |
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NCBI chr 7:8,733,056...8,738,543
Ensembl chr 7:8,082,364...8,098,914
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G
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Slc1a1
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solute carrier family 1 member 1
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multiple interactions decreases activity
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of SLC1A1 protein
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CTD |
PMID:16150575 PMID:23602688 PMID:24355585 |
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NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402
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G
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Slc1a2
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solute carrier family 1 member 2
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3-bis(4-hydroxyphenyl)-propionitrile results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4,4',4''-(4-propyl-((1)H)-pyrazole-1,3,5-triyl) tris-phenol results in increased expression of SLC1A2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[1-(4-(6-bromobenzo(1,3)dioxol-5-yl)-3a,4,5,9b-tetrahydro-3H-cyclopenta(c)quinolin-8-yl)ethanone binds to and results in increased activity of GPER1 protein] which results in increased expression of SLC1A2 protein]
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CTD |
PMID:22645130 PMID:24782323 |
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NCBI chr 3:109,460,109...109,590,445
Ensembl chr 3:89,005,129...89,126,498
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G
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Slc27a5
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solute carrier family 27 member 5
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in decreased expression of SLC27A5 mRNA]
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CTD |
PMID:25712622 |
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NCBI chr 1:73,616,556...73,627,149
Ensembl chr 1:73,616,564...73,627,172
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G
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Slc2a1
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solute carrier family 2 member 1
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multiple interactions decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of SLC2A1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased expression of SLC2A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phospholipids results in increased localization of SLC2A1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SLC2A1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [fosbretabulin analog results in decreased expression of SLC2A1 protein]; PTEN protein inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SLC2A1 protein]]; PTEN protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SLC2A1 protein]]
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CTD |
PMID:15956784 PMID:19808899 PMID:34147605 PMID:35122754 |
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NCBI chr 5:138,002,522...138,030,742
Ensembl chr 5:132,717,196...132,745,416
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G
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Slc2a4
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solute carrier family 2 member 4
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Anthraquinones co-treated with INS1 protein] affects the localization of SLC2A4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Anthraquinones affects the localization of SLC2A4 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [gypenoside LXXV affects the localization of SLC2A4 protein]
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CTD |
PMID:31071387 PMID:36325883 |
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NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
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G
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Slc2a5
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solute carrier family 2 member 5
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]
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CTD |
PMID:15691865 |
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NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:160,583,234...160,611,106
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G
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Slc5a5
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solute carrier family 5 member 5
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multiple interactions increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2,3',4,4',5-pentachlorobiphenyl results in decreased expression of SLC5A5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of SLC5A5 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-iodohexadecanal results in decreased expression of SLC5A5 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Potassium Iodide results in decreased expression of SLC5A5 mRNA]
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CTD |
PMID:20300827 PMID:25644787 PMID:38013145 |
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NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697
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G
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Slc6a3
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solute carrier family 6 member 3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Phentermine results in increased expression of SLC6A3 protein]
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CTD |
PMID:26887589 |
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NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
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G
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Slc7a11
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solute carrier family 7 member 11
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [ADORA2B protein affects the reaction [Palmitic Acid results in decreased expression of SLC7A11 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Palmitic Acid results in decreased expression of SLC7A11 protein]
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CTD |
PMID:38174997 |
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NCBI chr 2:134,382,002...134,517,622
Ensembl chr 2:133,963,107...134,517,536
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G
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Slc8a3
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solute carrier family 8 member A3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased expression of SLC8A3 protein]
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CTD |
PMID:33516933 |
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NCBI chr 6:100,874,359...101,007,989
Ensembl chr 6:100,874,369...101,007,508
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G
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Smad2
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SMAD family member 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in increased phosphorylation of SMAD2 protein]
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CTD |
PMID:27856280 |
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NCBI chr18:72,124,792...72,193,345
Ensembl chr18:69,850,377...69,912,323
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G
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Snai1
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snail family transcriptional repressor 1
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decreases expression multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SNAI1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; SB 216763 inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of SNAI1 protein]]
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CTD |
PMID:23921149 PMID:24122885 PMID:25118938 PMID:25656647 PMID:30609689 PMID:33396024 More...
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NCBI chr 3:176,667,476...176,671,965
Ensembl chr 3:156,248,485...156,252,969
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G
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Snai2
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snail family transcriptional repressor 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of SNAI2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 protein]
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CTD |
PMID:30609689 PMID:33396024 |
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NCBI chr11:99,686,934...99,690,349
Ensembl chr11:86,181,909...86,186,200
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G
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Socs3
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suppressor of cytokine signaling 3
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SOCS3 mRNA]
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CTD |
PMID:22685291 PMID:25712622 |
|
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
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G
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Sod1
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superoxide dismutase 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [miltirone inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased activity of SOD1 protein]]
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CTD |
PMID:35810264 |
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NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
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G
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Sod2
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superoxide dismutase 2
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increases expression multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of SOD2 mRNA 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in decreased expression of SOD2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in decreased expression of SOD2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Butyrates results in increased expression of SOD2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [LEPR gene mutant form results in decreased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased expression of SOD2 protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased expression of SOD2 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvin results in increased expression of SOD2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]
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CTD |
PMID:15308628 PMID:16256798 PMID:20542495 PMID:20596034 PMID:23159718 PMID:26577515 PMID:26686574 PMID:38729284 More...
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NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G
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Sox2
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SRY-box transcription factor 2
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decreases expression multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SOX2 protein [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with sodium arsenite] results in decreased expression of SOX2 protein
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CTD |
PMID:23143138 |
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NCBI chr 2:119,465,131...119,467,542
Ensembl chr 2:117,536,929...117,539,338
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G
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Sp1
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Sp1 transcription factor
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multiple interactions increases phosphorylation
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of SP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonyldichlororuthenium (II) dimer results in increased phosphorylation of SP1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of SP1 protein
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CTD |
PMID:17307335 PMID:21351249 PMID:26385185 |
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NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
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G
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Spp1
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secreted phosphoprotein 1
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of SPP1 protein]
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CTD |
PMID:19356721 |
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NCBI chr14:5,613,569...5,620,695
Ensembl chr14:5,308,885...5,315,162
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G
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Sqstm1
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sequestosome 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [Sijunzi decoction results in decreased expression of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [pachastrissamine analog results in increased expression of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SQSTM1 protein results in increased expression of NQO1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 affects the localization of SQSTM1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [notoginsenoside R1 inhibits the reaction [triethylene glycol dimethacrylate affects the localization of SQSTM1 protein]]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of SQSTM1 protein]
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CTD |
PMID:17360324 PMID:33689844 PMID:35123989 PMID:36343798 PMID:38729284 |
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NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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G
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Src
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SRC proto-oncogene, non-receptor tyrosine kinase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased phosphorylation of SRC protein]
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CTD |
PMID:29894800 |
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NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
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G
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Srebf1
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sterol regulatory element binding transcription factor 1
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multiple interactions decreases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [FGF7 protein results in increased expression of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [kahweol results in decreased expression of SREBF1 protein]; kahweol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of SREBF1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]
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CTD |
PMID:16162944 PMID:22031849 PMID:25398788 PMID:30205135 |
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NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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G
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Srr
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serine racemase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [methyllycaconitine results in increased expression of SRR protein]
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CTD |
PMID:24012499 |
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NCBI chr10:59,769,563...59,786,688
Ensembl chr10:59,769,571...59,787,011
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G
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Stat3
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signal transducer and activator of transcription 3
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multiple interactions increases phosphorylation
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IFNG protein results in decreased phosphorylation of STAT3 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased phosphorylation of and results in increased activity of STAT3 protein] Phosphocreatine inhibits the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of STAT3 protein]
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CTD |
PMID:16427044 PMID:29894800 PMID:34455488 |
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NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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G
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Stmn1
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stathmin 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [arsenic trioxide results in increased degradation of STMN1 protein]
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CTD |
PMID:20657188 |
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NCBI chr 5:151,964,308...151,970,843
Ensembl chr 5:146,681,436...146,687,154
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G
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Sts
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steroid sulfatase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tretinoin results in increased activity of STS protein]
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CTD |
PMID:16178010 PMID:24055520 |
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NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
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G
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Stx7
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syntaxin 7
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [1-Methyl-4-phenylpyridinium affects the expression of STX7 mRNA]
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CTD |
PMID:12710931 |
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NCBI chr 1:21,197,075...21,237,320
Ensembl chr 1:21,197,075...21,237,279
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G
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Syp
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synaptophysin
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multiple interactions increases expression
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ISO
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intybin promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of SYP protein]
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CTD |
PMID:28011163 |
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NCBI chr X:17,521,348...17,536,449
Ensembl chr X:14,849,444...14,864,745
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G
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Tert
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telomerase reverse transcriptase
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased activity of TERT protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Raloxifene Hydrochloride results in increased activity of TERT protein]
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CTD |
PMID:15590986 PMID:16798746 PMID:30851366 |
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NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561
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G
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Tf
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transferrin
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decreases activity
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased activity of TF protein
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CTD |
PMID:19238537 |
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NCBI chr 8:112,668,667...112,695,376
Ensembl chr 8:103,767,995...103,816,511
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G
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Tfam
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transcription factor A, mitochondrial
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multiple interactions
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EXP ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Calcitriol results in increased expression of TFAM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Carbon Monoxide results in increased expression of TFAM protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of TFAM mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of TFAM mRNA]
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CTD |
PMID:17179207 PMID:24041027 PMID:30194976 |
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NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
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G
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Tfrc
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transferrin receptor
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[lysophosphatidic acid co-treated with KITLG protein co-treated with EPO protein] results in increased expression of TFRC protein]
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CTD |
PMID:21915944 |
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NCBI chr11:68,163,413...68,185,257
Ensembl chr11:68,163,413...68,185,257
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G
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Tgfa
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transforming growth factor alpha
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenite results in increased expression of and results in increased secretion of TGFA protein]
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CTD |
PMID:36343453 |
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NCBI chr 4:120,175,549...120,258,342
Ensembl chr 4:118,618,269...118,700,894
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G
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Tgfb1
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transforming growth factor, beta 1
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decreases response to substance increases expression multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased susceptibility to TGFB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TGFB1 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SMARCA4A protein inhibits the reaction [Glucose results in increased expression of TGFB1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of and results in decreased secretion of IGF1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of ITGAM protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NOS2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CD mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of PIK3CG mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased activity of AHR protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of PIK3CB mRNA] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one analog inhibits the reaction [TGFB1 protein results in increased expression of CCN2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in decreased expression of BCL2 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin inhibits the reaction [TGFB1 results in increased expression of CASP3 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [delphinidin promotes the reaction [TGFB1 results in decreased expression of BAX protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of CDH1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of CDH2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of MMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of NOX4 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of SNAI2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased secretion of IL6 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of POSTN mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Silicon Dioxide results in increased expression of TGFB1 protein]
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CTD |
PMID:16325820 PMID:17082237 PMID:21131394 PMID:24727557 PMID:26054450 PMID:26254549 PMID:27020609 PMID:30365941 PMID:30609689 PMID:30611790 PMID:31522336 PMID:33270355 PMID:33720480 More...
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NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
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G
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Tgif1
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TGFB-induced factor homeobox 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]
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CTD |
PMID:21649584 PMID:25791921 |
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NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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G
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Tgm2
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transglutaminase 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Ethanol results in increased activity of TGM2 protein]
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CTD |
PMID:18295389 |
|
NCBI chr 3:146,772,684...146,801,924
Ensembl chr 3:146,772,687...146,801,981
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G
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Th
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tyrosine hydroxylase
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one affects the reaction [HU 211 results in decreased expression of TH mRNA]
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CTD |
PMID:18950629 |
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NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
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G
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Thbd
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thrombomodulin
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tamibarotene results in increased expression of THBD mRNA]
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CTD |
PMID:15020266 |
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NCBI chr 3:156,316,526...156,320,178
Ensembl chr 3:135,862,835...135,867,193
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G
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Thpo
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thrombopoietin
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [THPO protein results in increased expression of GP1BA protein]
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CTD |
PMID:20523355 |
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Ensembl chr11:80,182,820...80,188,167
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G
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Timp1
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TIMP metallopeptidase inhibitor 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [gadodiamide results in increased expression of TIMP1 protein]
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CTD |
PMID:19561517 |
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NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
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G
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Timp2
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TIMP metallopeptidase inhibitor 2
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol A results in increased expression of TIMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Diethylhexyl Phthalate results in increased expression of TIMP2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in decreased expression of TIMP2 protein]
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CTD |
PMID:19956873 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
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G
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Tjp1
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tight junction protein 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in decreased expression of TJP1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in decreased expression of TJP1 protein]
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CTD |
PMID:24200059 PMID:30609689 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
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G
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Tlr4
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toll-like receptor 4
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein]]
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CTD |
PMID:25171655 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
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G
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Tnf
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tumor necrosis factor
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multiple interactions increases response to substance
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [bisphenol F results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lead acetate results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [T-2 Toxin results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in decreased expression of CLDN5 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of RPS6 protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with U 0126] inhibits the reaction [lead acetate results in increased secretion of TNF protein]; [forsythiaside co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased susceptibility to TNF protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [1-nitropyrene results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [3-nitrofluoranthene results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Capsaicin results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of TNF mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Poly I-C results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of MMP1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of CD38 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased activity of MMP9 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CCL2 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CD38 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of CXCL8 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF results in increased expression of MMP9 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL1B mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of IL6 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased expression of MMP1 mRNA]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Dinoprostone]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL1B protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of IL6 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [rhodojaponin II inhibits the reaction [TNF protein results in increased secretion of Nitric Oxide]] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cysteine analog results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxepin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ferrous sulfate results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Iron results in increased secretion of TNF protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [trigonelline inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of TNF protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Silicon Dioxide results in increased expression of TNF protein]
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CTD |
PMID:12805067 PMID:14502240 PMID:16794257 PMID:17172471 PMID:17464197 PMID:17560598 PMID:19401153 PMID:20932985 PMID:21308383 PMID:21474332 PMID:22556157 PMID:24530660 PMID:24613819 PMID:25171655 PMID:25712622 PMID:26025059 PMID:26254549 PMID:26974319 PMID:28633978 PMID:31445927 PMID:31743544 PMID:31935362 PMID:32613688 PMID:33720480 PMID:34147605 PMID:38729284 PMID:39147216 More...
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NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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G
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Tnfaip3
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TNF alpha induced protein 3
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of TNFAIP3 protein
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CTD |
PMID:21173233 |
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NCBI chr 1:13,709,211...13,724,291
Ensembl chr 1:13,709,206...13,725,282
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G
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Tnfrsf10b
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TNF receptor superfamily member 10b
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increases expression multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFRSF10A protein]
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CTD |
PMID:15942663 PMID:21179458 |
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NCBI chr15:44,840,386...44,868,318
Ensembl chr15:44,840,386...44,867,467
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G
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Tnfsf10
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TNF superfamily member 10
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multiple interactions increases expression
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ISO
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[2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with TNFSF10 protein] results in increased activity of BAX protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of CASP3 protein; [TNFSF10 protein co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased cleavage of PARP1 protein; resveratrol promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TNFSF10 protein]
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CTD |
PMID:19261616 PMID:20097879 PMID:21179458 |
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NCBI chr 2:110,199,835...110,227,239
Ensembl chr 2:110,207,916...110,225,135
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G
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Tnfsf11
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TNF superfamily member 11
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNFSF11 protein results in increased phosphorylation of RPS6 protein]
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CTD |
PMID:14502240 |
|
NCBI chr15:60,083,008...60,114,479
Ensembl chr15:53,673,877...53,705,445
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G
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Tp53
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tumor protein p53
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multiple interactions increases phosphorylation increases expression
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [ANGPT1 protein inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [di-n-propyldithiocarbamate results in increased expression of and results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Doxorubicin results in increased expression of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Fluorometholone inhibits the reaction [Glucose results in increased expression of TP53 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in decreased expression of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of and results in decreased phosphorylation of TP53 protein; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with cyadox] results in increased expression of TP53 mRNA; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Hydrogen Peroxide] results in increased expression of TP53 mRNA; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP3 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP8 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]]; TP53 protein promotes the reaction [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [Doxorubicin results in increased expression of and results in increased activity of BAX protein]]; TP53 protein promotes the reaction [[Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of BBC3 protein]; TP53 protein results in increased susceptibility to [Doxorubicin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[Deferoxamine results in increased activity of TP53 protein] which results in increased ubiquitination of and results in increased degradation of and results in decreased expression of HIF1A protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased phosphorylation of TP53 protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TP53 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in increased expression of TP53 protein
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CTD |
PMID:15001399 PMID:15763944 PMID:16024610 PMID:17534123 PMID:19950214 PMID:20856197 PMID:25305377 PMID:26942697 PMID:30265530 PMID:32687844 PMID:34677630 PMID:35264022 More...
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NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G
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Trim63
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tripartite motif containing 63
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decreases expression
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of TRIM63 mRNA
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CTD |
PMID:21832246 |
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NCBI chr 5:146,533,492...146,547,332
Ensembl chr 5:146,533,507...146,547,322
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G
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Trpv1
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transient receptor potential cation channel, subfamily V, member 1
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased localization of TRPV1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NGF results in increased phosphorylation of TRPV1 protein]
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CTD |
PMID:16319926 |
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NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
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G
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Ttn
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titin
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Triiodothyronine affects the expression of TTN mRNA]
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CTD |
PMID:18096819 |
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NCBI chr 3:61,652,432...61,924,912
Ensembl chr 3:61,652,439...61,924,741
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G
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Twist1
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twist family bHLH transcription factor 1
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of TWIST1 protein]]
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CTD |
PMID:33396024 |
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NCBI chr 6:56,402,309...56,404,303
Ensembl chr 6:50,674,678...50,677,653
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G
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Txn1
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thioredoxin 1
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multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TXN protein results in decreased susceptibility to Oxygen] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TXN1 protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Nicotine results in increased expression of TXN1 protein]
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CTD |
PMID:20812253 PMID:28082123 |
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NCBI chr 5:77,507,455...77,519,685
Ensembl chr 5:72,711,933...72,724,629
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G
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Txnrd1
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thioredoxin reductase 1
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multiple interactions
|
EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [2-iodohexadecanal results in decreased expression of TXNRD1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Potassium Iodide results in decreased expression of TXNRD1 mRNA]
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CTD |
PMID:38013145 |
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NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863
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G
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Tyr
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tyrosinase
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYR protein]; [Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR protein [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein
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CTD |
PMID:21816215 PMID:28849034 |
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NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
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G
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Tyrp1
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tyrosinase-related protein 1
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Drugs, Chinese Herbal results in decreased expression of TYRP1 protein]
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CTD |
PMID:21816215 |
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NCBI chr 5:100,327,111...100,345,657
Ensembl chr 5:95,280,982...95,299,516
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G
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Ucp1
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uncoupling protein 1
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multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in decreased expression of UCP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF1 protein results in increased expression of UCP1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [FGF2 protein results in increased expression of UCP1 mRNA]
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CTD |
PMID:11742803 |
|
NCBI chr19:41,713,350...41,721,421
Ensembl chr19:24,808,783...24,816,852
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G
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Ugt1a1
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UDP glucuronosyltransferase family 1 member A1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [erucin results in increased expression of UGT1A1 mRNA]
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CTD |
PMID:15896333 |
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NCBI chr 9:96,249,143...96,256,264
Ensembl chr 9:88,713,184...88,808,465
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G
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Uqcrc1
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ubiquinol-cytochrome c reductase core protein 1
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltiprotoporphyrin results in increased expression of UQCRC1 protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [tricarbonylchloro(glycinato)ruthenium(II) results in increased expression of UQCRC1 protein]
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CTD |
PMID:24041027 |
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NCBI chr 8:118,468,223...118,479,968
Ensembl chr 8:109,589,706...109,601,480
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G
|
Vcam1
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vascular cell adhesion molecule 1
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Particulate Matter results in increased expression of VCAM1 protein]
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CTD |
PMID:25876056 |
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NCBI chr 2:206,723,050...206,742,783
Ensembl chr 2:204,038,114...204,057,958
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G
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Vdr
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vitamin D receptor
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [HRAS protein inhibits the reaction [1,25-dihydroxyvitamin D results in increased activity of VDR protein]]
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CTD |
PMID:18829283 |
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NCBI chr 7:130,864,764...130,916,757
Ensembl chr 7:128,987,981...129,037,677
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G
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Vegfa
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vascular endothelial growth factor A
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decreases expression decreases reaction decreases secretion multiple interactions
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ISO EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of VEGFA mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of VEGFA protein LY294002 inhibits the reaction [estrogen increases expression of Vegfa mRNA] in rat uterus 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased secretion of VEGFA protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[nickel chloride results in increased abundance of Nickel] which results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Cadmium Chloride results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cobaltous chloride results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cornin iridoid results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [EGF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [NLRC5 protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Oxygen deficiency results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased expression of VEGFA mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TNF protein results in increased secretion of VEGFA protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one promotes the reaction [VEGFA protein results in increased expression of SOD2 mRNA]
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CTD RGD |
PMID:15040022 PMID:15050414 PMID:15308628 PMID:15930297 PMID:16638750 PMID:16682453 PMID:18252963 PMID:20850416 PMID:21647420 PMID:21984483 PMID:22859221 PMID:23702325 PMID:23968725 PMID:24613819 PMID:26974319 PMID:27338800 PMID:30724446 PMID:34978009 PMID:17272396 More...
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RGD:152177689 |
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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G
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Vegfc
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vascular endothelial growth factor C
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multiple interactions
|
ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [VEGFC protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:29169284 |
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NCBI chr16:44,445,293...44,560,887
Ensembl chr16:37,712,262...37,827,848
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G
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Vim
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vimentin
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multiple interactions
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [CXCL8 protein promotes the reaction [[sodium arsenite results in increased abundance of Arsenic] which results in increased expression of VIM protein]]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [cyanoginosin LR results in decreased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of VIM protein]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [TGFB1 protein results in increased expression of VIM protein]
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CTD |
PMID:25656647 PMID:27856280 PMID:30609689 PMID:33396024 |
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NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
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G
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Wnt5a
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Wnt family member 5A
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multiple interactions
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [loliolide results in increased expression of WNT5A mRNA]
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CTD |
PMID:31601058 |
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NCBI chr16:3,702,300...3,724,860
Ensembl chr16:3,697,032...3,718,234
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G
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Xiap
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X-linked inhibitor of apoptosis
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multiple interactions decreases expression
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ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Thapsigargin results in increased expression of XIAP protein]; [2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one co-treated with Doxorubicin] results in decreased expression of XIAP protein 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased expression of XIAP protein
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CTD |
PMID:15339911 PMID:18071906 PMID:20856197 |
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NCBI chr X:125,756,107...125,803,979
Ensembl chr X:120,897,907...120,934,700
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G
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Xrcc1
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X-ray repair cross complementing 1
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multiple interactions decreases stability
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ISO
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 mRNA]; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Etoposide results in increased expression of XRCC1 protein] 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased stability of XRCC1 mRNA; 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one results in decreased stability of XRCC1 protein
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CTD |
PMID:26046675 |
|
NCBI chr 1:80,140,495...80,168,705
Ensembl chr 1:80,141,207...80,168,701
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G
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Zc3h12a
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zinc finger CCCH type containing 12A
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multiple interactions
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EXP
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2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [Silicon Dioxide results in increased expression of ZC3H12A protein]
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CTD |
PMID:26865670 |
|
NCBI chr 5:142,661,193...142,670,051
Ensembl chr 5:137,376,564...137,385,351
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G
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Abcb11
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ATP binding cassette subfamily B member 11
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multiple interactions decreases activity
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ISO
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Nicardipine inhibits the reaction [ABCB11 protein results in increased transport of Taurocholic Acid] Nicardipine results in decreased activity of ABCB11 protein
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CTD |
PMID:20829430 PMID:23956101 PMID:24014644 |
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NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
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G
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Abcb1a
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ATP binding cassette subfamily B member 1A
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multiple interactions
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ISO
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Nicardipine inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
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CTD |
PMID:11895100 |
|
NCBI chr 4:26,312,403...26,488,456
Ensembl chr 4:25,158,362...25,442,709
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G
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Aco2
|
aconitase 2
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multiple interactions
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ISO
|
[Nicardipine results in decreased uptake of Calcium] which results in decreased activity of ACO2 protein
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CTD |
PMID:12548706 |
|
NCBI chr 7:113,385,677...113,428,794
Ensembl chr 7:113,385,646...113,428,261
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G
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Ahr
|
aryl hydrocarbon receptor
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multiple interactions increases activity
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ISO
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Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of AHR protein]; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of AHR protein]
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CTD |
PMID:20067464 |
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NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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G
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Avp
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arginine vasopressin
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multiple interactions
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EXP
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Nicardipine inhibits the reaction [AVP protein results in increased import of and results in increased abundance of Calcium]
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CTD |
PMID:14711191 |
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NCBI chr 3:138,246,544...138,248,522
Ensembl chr 3:117,793,457...117,795,425
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G
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Bdnf
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brain-derived neurotrophic factor
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multiple interactions
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EXP
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Nicardipine inhibits the reaction [decamethrin results in increased expression of BDNF mRNA]
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CTD |
PMID:16166269 PMID:22079160 |
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NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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G
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Camk2a
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calcium/calmodulin-dependent protein kinase II alpha
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multiple interactions
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EXP
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Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]
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CTD |
PMID:11073891 |
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NCBI chr18:56,648,779...56,711,505
Ensembl chr18:54,378,784...54,438,994
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G
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Camk4
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calcium/calmodulin-dependent protein kinase IV
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multiple interactions
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EXP
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Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]
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CTD |
PMID:11073891 |
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NCBI chr18:24,857,152...25,076,054
Ensembl chr18:24,585,269...24,802,487
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G
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Ccnd1
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cyclin D1
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decreases expression
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ISO
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Nicardipine results in decreased expression of CCND1 protein
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CTD |
PMID:17217918 |
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G
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Cdk2
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cyclin dependent kinase 2
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decreases activity
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ISO
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Nicardipine results in decreased activity of CDK2 protein
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CTD |
PMID:17217918 |
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NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G
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Crat
|
carnitine O-acetyltransferase
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multiple interactions
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EXP
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Nicardipine results in decreased activity of [Clofibrate results in increased expression of CRAT protein]
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CTD |
PMID:1914008 |
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NCBI chr 3:34,073,504...34,087,099
Ensembl chr 3:13,675,684...13,689,255
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G
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Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
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multiple interactions decreases activity increases expression
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ISO
|
Methylcholanthrene promotes the reaction [Nicardipine results in increased activity of and results in increased expression of CYP1A1 protein]; Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A1 mRNA]; Nicardipine promotes the reaction [Methylcholanthrene results in increased activity of and results in increased expression of CYP1A1 protein]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A1 mRNA] Nicardipine results in decreased activity of CYP1A1 protein Nicardipine results in increased expression of CYP1A1 mRNA; Nicardipine results in increased expression of CYP1A1 protein
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CTD |
PMID:15863898 PMID:20067464 |
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NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G
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Cyp1a2
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cytochrome P450, family 1, subfamily a, polypeptide 2
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multiple interactions decreases activity increases expression
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ISO
|
Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1A2 mRNA]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1A2 mRNA] Nicardipine results in decreased activity of CYP1A2 protein
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CTD |
PMID:15863898 PMID:20067464 |
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NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G
|
Cyp1b1
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cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions
|
ISO
|
Methylcholanthrene promotes the reaction [Nicardipine results in increased expression of CYP1B1 mRNA]; Nicardipine promotes the reaction [Methylcholanthrene results in increased expression of CYP1B1 mRNA]
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CTD |
PMID:20067464 |
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NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G
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Cyp2c6
|
cytochrome P450, family 2, subfamily C, polypeptide 6
|
decreases activity
|
ISO
|
Nicardipine results in decreased activity of CYP2C19 protein
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CTD |
PMID:10805063 PMID:15863898 |
|
NCBI chr 1:247,879,058...247,916,804
Ensembl chr 1:237,693,094...238,057,596
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G
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Cyp2c79
|
cytochrome P450, family 2, subfamily c, polypeptide 79
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affects metabolic processing decreases activity
|
ISO
|
CYP2C8 protein affects the metabolism of Nicardipine Nicardipine results in decreased activity of CYP2C8 protein
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CTD |
PMID:15863898 |
|
|
|
G
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Cyp2d4
|
cytochrome P450, family 2, subfamily d, polypeptide 4
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affects metabolic processing multiple interactions decreases activity
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ISO
|
CYP2D6 protein affects the metabolism of Nicardipine Nicardipine inhibits the reaction [CYP2D6 protein results in decreased methylation of Dextromethorphan]; Nicardipine inhibits the reaction [CYP2D6 protein results in increased hydroxylation of mequitazine] Nicardipine results in decreased activity of CYP2D6 protein
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CTD |
PMID:10805063 PMID:15863898 |
|
NCBI chr 7:115,762,662...115,771,832
Ensembl chr 7:113,881,618...113,891,759
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G
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Cyp2j4
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cytochrome P450, family 2, subfamily j, polypeptide 4
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decreases activity
|
ISO
|
Nicardipine results in decreased activity of CYP2J2 protein
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CTD |
PMID:30965050 |
|
NCBI chr 5:116,295,691...116,323,219
Ensembl chr 5:111,178,703...111,244,794
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G
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Cyp3a2
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cytochrome P450, family 3, subfamily a, polypeptide 2
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affects metabolic processing decreases activity multiple interactions
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ISO
|
CYP3A4 protein affects the metabolism of Nicardipine Nicardipine results in decreased activity of CYP3A4 protein [Nicardipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA; Nicardipine inhibits the reaction [CYP3A4 protein results in increased hydroxylation of Triazolam]
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CTD |
PMID:10805063 PMID:15860655 PMID:15863898 PMID:17041008 |
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NCBI chr12:14,321,771...14,343,886
Ensembl chr12:9,015,383...9,285,008
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G
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Cyp3a23-3a1
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cytochrome P450, family 3, subfamily a, polypeptide 23-polypeptide 1
|
increases expression
|
EXP
|
Nicardipine results in increased expression of CYP3A23-3A1 mRNA
|
CTD |
PMID:16125621 |
|
NCBI chr12:14,369,950...14,398,803
Ensembl chr12:9,254,475...9,285,030 Ensembl chr12:9,254,475...9,285,030
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|
G
|
Esr1
|
estrogen receptor 1
|
decreases activity
|
ISO
|
Nicardipine results in decreased activity of ESR1 protein
|
CTD |
PMID:25257666 |
|
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
|
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G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP
|
Nicardipine inhibits the reaction [Pyrithiamine results in increased expression of FOS mRNA]
|
CTD |
PMID:8229066 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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G
|
Hnmt
|
histamine N-methyltransferase
|
decreases activity
|
EXP
|
Nicardipine results in decreased activity of HNMT protein
|
CTD |
PMID:2408645 |
|
NCBI chr 3:6,591,804...6,623,821
Ensembl chr 3:6,591,463...6,624,012
|
|
G
|
Il4
|
interleukin 4
|
decreases secretion
|
ISO
|
Nicardipine results in decreased secretion of IL4 protein
|
CTD |
PMID:16533816 |
|
NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G
|
Il5
|
interleukin 5
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decreases secretion
|
ISO
|
Nicardipine results in decreased secretion of IL5 protein
|
CTD |
PMID:16533816 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:37,874,342...37,877,213
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G
|
Lif
|
LIF, interleukin 6 family cytokine
|
multiple interactions
|
EXP
|
Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK2A protein]; Nicardipine inhibits the reaction [LIF protein results in increased activity of CAMK4 protein]; Nicardipine inhibits the reaction [LIF protein results in increased phosphorylation of CAMK2A protein]
|
CTD |
PMID:11073891 |
|
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
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G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
EXP
|
Nicardipine inhibits the reaction [decamethrin results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:16166269 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
EXP
|
Nicardipine inhibits the reaction [decamethrin results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:16166269 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
|
Ncoa2
|
nuclear receptor coactivator 2
|
multiple interactions
|
ISO
|
Nicardipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]
|
CTD |
PMID:27773686 |
|
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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|
G
|
Nefl
|
neurofilament light chain
|
multiple interactions
|
EXP
|
Nicardipine inhibits the reaction [Rotenone results in decreased expression of NEFL mRNA]
|
CTD |
PMID:31969611 |
|
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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|
G
|
Nr1h4
|
nuclear receptor subfamily 1, group H, member 4
|
multiple interactions increases activity
|
ISO
|
Nicardipine inhibits the reaction [Chenodeoxycholic Acid promotes the reaction [NCOA2 protein modified form binds to NR1H4 protein]]; Nicardipine inhibits the reaction [Chenodeoxycholic Acid results in increased activity of NR1H4 protein]; Nicardipine inhibits the reaction [pregna-4,17-diene-3,16-dione results in decreased activity of NR1H4 protein] Nicardipine results in increased activity of NR1H4 protein
|
CTD |
PMID:25257666 PMID:27773686 |
|
NCBI chr 7:25,733,471...25,829,440
Ensembl chr 7:23,846,122...23,942,047
|
|
G
|
Nr1i2
|
nuclear receptor subfamily 1, group I, member 2
|
multiple interactions increases activity
|
ISO
|
[Nicardipine results in increased activity of NR1I2 protein] which results in increased expression of CYP3A4 mRNA
|
CTD |
PMID:17041008 PMID:25455453 |
|
NCBI chr11:75,965,717...76,006,733
Ensembl chr11:62,460,213...62,496,658
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
decreases activity
|
ISO
|
Nicardipine results in decreased activity of PPARG protein
|
CTD |
PMID:25257666 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ren
|
renin
|
increases activity
|
ISO
|
Nicardipine results in increased activity of REN protein
|
CTD |
PMID:1867428 |
|
NCBI chr13:47,348,312...47,359,539
Ensembl chr13:44,796,091...44,807,489
|
|
G
|
Sct
|
secretin
|
multiple interactions
|
EXP
|
Nicardipine inhibits the reaction [Potassium Chloride results in increased secretion of SCT protein]
|
CTD |
PMID:16888165 |
|
NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
|
|
G
|
Slc22a2
|
solute carrier family 22 member 2
|
multiple interactions
|
ISO
|
Nicardipine inhibits the reaction [SLC22A2 protein results in increased uptake of 4-(4-dimethylaminostyryl)-1-methylpyridinium]
|
CTD |
PMID:21599003 |
|
NCBI chr 1:50,668,817...50,711,019
Ensembl chr 1:48,121,061...48,163,268
|
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
decreases phosphorylation multiple interactions
|
ISO
|
PX-866 results in decreased phosphorylation of AKT1 protein PX-866 inhibits the reaction [[Calcium co-treated with Ionomycin] results in increased phosphorylation of AKT1 protein]; PX-866 promotes the reaction [STO 609 results in decreased phosphorylation of AKT1 protein]; STO 609 promotes the reaction [PX-866 results in decreased phosphorylation of AKT1 protein]
|
CTD |
PMID:25805502 PMID:28634229 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Axin2
|
axin 2
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of AXIN2 mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr10:94,393,379...94,426,579
Ensembl chr10:93,899,245...93,926,231
|
|
G
|
Bad
|
BCL2-associated agonist of cell death
|
decreases phosphorylation multiple interactions
|
ISO
|
PX-866 results in decreased phosphorylation of BAD protein [PX-866 co-treated with BBR3610] results in decreased phosphorylation of BAD protein
|
CTD |
PMID:20473884 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
|
|
G
|
Bhlhe40
|
basic helix-loop-helix family, member e40
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of BHLHE40 mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr 4:143,174,450...143,180,150
Ensembl chr 4:141,618,476...141,624,774
|
|
G
|
Camkk2
|
calcium/calmodulin-dependent protein kinase kinase 2
|
affects response to substance
|
ISO
|
CAMKK2 protein affects the susceptibility to PX-866
|
CTD |
PMID:28634229 |
|
NCBI chr12:39,451,828...39,505,719
Ensembl chr12:33,791,052...33,843,279
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|
G
|
Ccnd1
|
cyclin D1
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCND1 mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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|
G
|
Ccne2
|
cyclin E2
|
decreases expression multiple interactions
|
ISO
|
PX-866 results in decreased expression of CCNE2 mRNA [Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CCNE2 mRNA
|
CTD |
PMID:26660119 |
|
NCBI chr 5:29,082,169...29,094,879
Ensembl chr 5:24,284,922...24,297,632
|
|
G
|
Cd36
|
CD36 molecule
|
multiple interactions
|
ISO
|
[PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA
|
CTD |
PMID:25805502 |
|
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
|
|
G
|
Cdc6
|
cell division cycle 6
|
multiple interactions decreases expression
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of CDC6 mRNA PX-866 results in decreased expression of CDC6 mRNA
|
CTD |
PMID:26660119 |
|
NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in increased expression of CDKN1A mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Cyp7a1
|
cytochrome P450 family 7 subfamily A member 1
|
multiple interactions
|
ISO
|
[PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA
|
CTD |
PMID:25805502 |
|
NCBI chr 5:19,376,979...19,386,676
Ensembl chr 5:19,376,974...19,386,688
|
|
G
|
E2f1
|
E2F transcription factor 1
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of E2F1 mRNA
|
CTD |
PMID:26660119 |
|
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
|
|
G
|
Fasn
|
fatty acid synthase
|
multiple interactions
|
ISO
|
PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]
|
CTD |
PMID:25805502 |
|
NCBI chr10:106,570,415...106,588,581
Ensembl chr10:106,072,091...106,090,261
|
|
G
|
Hbegf
|
heparin-binding EGF-like growth factor
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of HBEGF mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr18:28,380,337...28,390,220
Ensembl chr18:28,105,760...28,116,441
|
|
G
|
Il11
|
interleukin 11
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of IL11 mRNA
|
CTD |
PMID:26660119 |
|
NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129
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|
G
|
Lif
|
LIF, interleukin 6 family cytokine
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of LIF mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr14:83,354,602...83,364,053
Ensembl chr14:79,134,574...79,140,482
|
|
G
|
Mdm2
|
MDM2 proto-oncogene
|
decreases phosphorylation multiple interactions
|
ISO
|
PX-866 results in decreased phosphorylation of MDM2 protein [Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of MDM2 protein
|
CTD |
PMID:27017931 |
|
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
|
|
G
|
Mttp
|
microsomal triglyceride transfer protein
|
multiple interactions
|
ISO
|
PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]
|
CTD |
PMID:25805502 |
|
NCBI chr 2:226,613,090...226,654,239
Ensembl chr 2:226,613,090...226,654,239
|
|
G
|
Rb1
|
RB transcriptional corepressor 1
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased phosphorylation of RB1 protein
|
CTD |
PMID:26660119 |
|
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
|
|
G
|
Scd
|
stearoyl-CoA desaturase
|
multiple interactions
|
ISO
|
PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]
|
CTD |
PMID:25805502 |
|
NCBI chr 1:253,218,968...253,232,101
Ensembl chr 1:243,269,747...243,282,562
|
|
G
|
Sort1
|
sortilin 1
|
multiple interactions decreases expression
|
ISO
|
[PX-866 co-treated with SORT1 protein] results in decreased expression of CD36 mRNA; [PX-866 co-treated with SORT1 protein] results in decreased expression of CYP7A1 mRNA; PX-866 promotes the reaction [SORT1 protein results in decreased expression of FASN mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of MTTP mRNA]; PX-866 promotes the reaction [SORT1 protein results in decreased expression of SCD1 mRNA]; SORT1 protein inhibits the reaction [PX-866 results in increased abundance of Triglycerides] PX-866 results in decreased expression of SORT1 protein
|
CTD |
PMID:25805502 |
|
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
|
|
G
|
Tert
|
telomerase reverse transcriptase
|
multiple interactions
|
ISO
|
[Raloxifene Hydrochloride co-treated with PX-866] results in decreased expression of TERT mRNA
|
CTD |
PMID:27017931 |
|
NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561
|
|
|
G
|
Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of ACTA2 protein] salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of ACTA2 protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of ACTA2 protein]
|
CTD |
PMID:19822164 PMID:33290806 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions increases phosphorylation
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:22545124 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions
|
EXP ISO
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; salvianolic acid B inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]; salvianolic acid B inhibits the reaction [Cisplatin results in increased expression of BAX protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of BAX protein]
|
CTD |
PMID:23201927 PMID:28495616 PMID:33952797 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions increases expression
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein]]; salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2 protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein] salvianolic acid B results in increased expression of BCL2 protein
|
CTD |
PMID:23201927 PMID:28495616 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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|
G
|
Bcl2l1
|
Bcl2-like 1
|
multiple interactions increases expression
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]]; salvianolic acid B inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of BCL2L1 protein] salvianolic acid B results in increased expression of BCL2L1 protein
|
CTD |
PMID:23201927 PMID:24769256 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
|
|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
increases expression multiple interactions
|
ISO
|
salvianolic acid B results in increased expression of BDNF protein salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BDNF protein]
|
CTD |
PMID:24991814 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
|
|
G
|
Casp1
|
caspase 1
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP1 mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP1 protein]
|
CTD |
PMID:33994527 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
|
|
G
|
Casp3
|
caspase 3
|
multiple interactions
|
EXP
|
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one inhibits the reaction [salvianolic acid B inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]]; salvianolic acid B inhibits the reaction [arsenic trioxide results in increased activity of CASP3 protein]; salvianolic acid B inhibits the reaction [Doxorubicin results in increased cleavage of CASP3 protein]; salvianolic acid B inhibits the reaction [Ethanol results in increased cleavage of CASP3 protein]
|
CTD |
PMID:23201927 PMID:24769256 PMID:28495616 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in decreased expression of CAT protein]
|
CTD |
PMID:35795853 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:89,842,399...89,874,478
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]] salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]]
|
CTD |
PMID:33290806 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
|
|
G
|
Col1a2
|
collagen type I alpha 2 chain
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA]
|
CTD |
PMID:19474275 |
|
NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
|
|
G
|
Crp
|
C-reactive protein
|
multiple interactions decreases expression
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CRP mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CRP protein] salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CRP protein]; SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein]
|
CTD |
PMID:27989594 |
|
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
|
|
G
|
Cul3
|
cullin 3
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 mRNA]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in increased expression of CUL3 protein]
|
CTD |
PMID:38272317 |
|
NCBI chr 9:89,040,987...89,118,775
Ensembl chr 9:81,592,641...81,670,462
|
|
G
|
Cxcl3
|
C-X-C motif chemokine ligand 3
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL1 mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of CXCL1 protein]
|
CTD |
PMID:35795853 |
|
NCBI chr14:17,287,727...17,289,451
Ensembl chr14:17,270,146...17,289,511
|
|
G
|
Cybb
|
cytochrome b-245 beta chain
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of CYBB protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of CYBB protein]
|
CTD |
PMID:19822164 |
|
NCBI chr X:16,030,596...16,065,065
Ensembl chr X:13,359,430...13,392,586
|
|
G
|
Cyp2e1
|
cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of CYP2E1 protein]
|
CTD |
PMID:27989594 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
|
|
G
|
Ddit3
|
DNA-damage inducible transcript 3
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of DDIT3 protein]
|
CTD |
PMID:28495616 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
|
|
G
|
Gdnf
|
glial cell derived neurotrophic factor
|
increases expression multiple interactions increases secretion
|
ISO
|
salvianolic acid B results in increased expression of GDNF mRNA NFE2L2 protein affects the reaction [salvianolic acid B results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [salvianolic acid B results in increased secretion of GDNF protein]
|
CTD |
PMID:24991814 |
|
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Ethanol results in increased activity of GPT protein]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of GPT protein] salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GPT protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of GPT protein]
|
CTD |
PMID:24769256 PMID:27989594 PMID:33290806 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Gstp1
|
glutathione S-transferase pi 1
|
multiple interactions
|
ISO
|
salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]]
|
CTD |
PMID:33290806 |
|
NCBI chr 1:210,767,237...210,770,242
Ensembl chr 1:201,321,672...201,340,226
|
|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of HMOX1 mRNA] salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of HMOX1 protein]
|
CTD |
PMID:33952797 PMID:38272317 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Hnf1a
|
HNF1 homeobox A
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of HNF1A protein]
|
CTD |
PMID:27989594 |
|
NCBI chr12:47,299,171...47,333,457
Ensembl chr12:41,645,587...41,672,104
|
|
G
|
Hspa5
|
heat shock protein family A (Hsp70) member 5
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of HSPA5 protein]
|
CTD |
PMID:28495616 |
|
NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of IL1B protein] salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IL1B protein] NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of IL1B protein]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B protein]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IL1B mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IL1B protein]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]
|
CTD |
PMID:19822164 PMID:24991814 PMID:33994527 PMID:35795853 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of IL6 protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of IL6 protein] salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of IL6 protein]
|
CTD |
PMID:19822164 PMID:24769256 PMID:27989594 PMID:35795853 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:35795853 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:35795853 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
|
|
G
|
Mlxipl
|
MLX interacting protein-like
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]; SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]]
|
CTD |
PMID:27989594 |
|
NCBI chr12:21,541,608...21,577,120
Ensembl chr12:21,543,576...21,577,112
|
|
G
|
Msra
|
methionine sulfoxide reductase A
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MSRA protein]
|
CTD |
PMID:38272317 |
|
NCBI chr15:38,363,459...38,677,406
Ensembl chr15:38,351,445...38,676,585
|
|
G
|
Msrb2
|
methionine sulfoxide reductase B2
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of MSRB2 protein]
|
CTD |
PMID:38272317 |
|
NCBI chr17:81,974,378...82,000,044
Ensembl chr17:81,974,196...82,000,043
|
|
G
|
Myc
|
MYC proto-oncogene, bHLH transcription factor
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]; salvianolic acid B inhibits the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine results in increased expression of MYC protein]]; SMAD3 protein modified form affects the reaction [salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]]
|
CTD |
PMID:33290806 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
|
|
G
|
Myd88
|
MYD88, innate immune signal transduction adaptor
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of MYD88 mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of MYD88 protein]
|
CTD |
PMID:35795853 |
|
NCBI chr 8:127,952,161...127,956,230
Ensembl chr 8:119,074,437...119,079,415
|
|
G
|
Ncf1
|
neutrophil cytosolic factor 1
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of NCF1 protein]
|
CTD |
PMID:19822164 |
|
NCBI chr12:28,121,816...28,131,080
Ensembl chr12:22,485,451...22,494,646
|
|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions increases expression
|
ISO EXP
|
NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]]; NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; NFE2L2 protein affects the reaction [salvianolic acid B results in increased expression of GDNF mRNA]; NFE2L2 protein affects the reaction [salvianolic acid B results in increased secretion of GDNF protein]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of NFE2L2 protein]; salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of NFE2L2 protein]; salvianolic acid B results in increased secretion of and affects the localization of NFE2L2 protein salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 mRNA]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NFE2L2 protein] salvianolic acid B results in increased expression of NFE2L2 protein
|
CTD |
PMID:24991814 PMID:33952797 PMID:38272317 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
|
|
G
|
Nlrp3
|
NLR family, pyrin domain containing 3
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NLRP3 mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of NLRP3 protein]
|
CTD |
PMID:33994527 PMID:35795853 |
|
NCBI chr10:44,826,299...44,853,373
Ensembl chr10:44,328,566...44,352,811
|
|
G
|
Nono
|
non-POU domain containing, octamer-binding
|
multiple interactions
|
ISO
|
NONO protein promotes the reaction [salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 mRNA]]; NONO protein promotes the reaction [salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein]]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NONO mRNA]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NONO protein]
|
CTD |
PMID:38272317 |
|
NCBI chr X:66,554,131...66,571,992
Ensembl chr X:66,554,098...66,571,952
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of NOS2 protein]
|
CTD |
PMID:19822164 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions
|
ISO EXP
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NQO1 protein]; salvianolic acid B inhibits the reaction [Cisplatin results in decreased expression of NQO1 mRNA] NONO protein promotes the reaction [salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 mRNA]]; NONO protein promotes the reaction [salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein]]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 mRNA]; salvianolic acid B inhibits the reaction [tert-Butylhydroperoxide results in decreased expression of NQO1 protein]
|
CTD |
PMID:33952797 PMID:33994527 PMID:38272317 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
|
|
G
|
Nrf1
|
nuclear respiratory factor 1
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NRF1 mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of NRF1 protein]
|
CTD |
PMID:33994527 |
|
NCBI chr 4:58,664,932...58,772,328
Ensembl chr 4:58,664,957...58,825,328
|
|
G
|
Pdgfb
|
platelet derived growth factor subunit B
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [PDGFB protein results in increased abundance of Hydrogen Peroxide]; salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of ACTA2 protein]; salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of CYBB protein]; salvianolic acid B inhibits the reaction [PDGFB protein results in increased expression of NCF1 protein]
|
CTD |
PMID:19822164 |
|
NCBI chr 7:113,419,882...113,438,343
Ensembl chr 7:111,540,345...111,557,984
|
|
G
|
Ppargc1a
|
PPARG coactivator 1 alpha
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Ethanol results in increased acetylation of PPARGC1A protein]
|
CTD |
PMID:24769256 |
|
NCBI chr14:63,073,505...63,729,215
Ensembl chr14:58,861,144...59,512,656
|
|
G
|
Serpine1
|
serpin family E member 1
|
multiple interactions
|
ISO
|
salvianolic acid B affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]; salvianolic acid B affects the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]
|
CTD |
PMID:33290806 |
|
NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
|
|
G
|
Sirt1
|
sirtuin 1
|
increases expression multiple interactions
|
ISO EXP
|
salvianolic acid B results in increased expression of SIRT1 protein salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [salvianolic acid B results in decreased expression of CRP protein] salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 mRNA]; salvianolic acid B inhibits the reaction [Ethanol results in decreased expression of SIRT1 protein]; SIRT1 protein affects the reaction [salvianolic acid B inhibits the reaction [Ethanol results in increased expression of MLXIPL protein]]
|
CTD |
PMID:24769256 PMID:27989594 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
|
|
G
|
Sirt3
|
sirtuin 3
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT3 protein]
|
CTD |
PMID:33994527 |
|
NCBI chr 1:195,942,066...195,964,472
Ensembl chr 1:195,942,073...195,964,808
|
|
G
|
Smad3
|
SMAD family member 3
|
multiple interactions affects response to substance
|
ISO
|
salvianolic acid B affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of ACTA2 protein]]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GPT protein]]; salvianolic acid B affects the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased expression of GSTP1 protein]]; salvianolic acid B affects the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine affects the expression of SERPINE1 protein]]; salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of SMAD3 protein]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of CDKN1A protein]]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in decreased expression of SMAD3 protein modified form]]; salvianolic acid B inhibits the reaction [SMAD3 protein modified form affects the reaction [Diethylnitrosamine results in increased phosphorylation of SMAD3 protein]]; salvianolic acid B inhibits the reaction [SMAD3 protein mutant form affects the reaction [Diethylnitrosamine results in increased expression of MYC protein]]; SMAD3 protein modified form affects the reaction [salvianolic acid B inhibits the reaction [Diethylnitrosamine results in increased expression of MYC protein]] salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]] SMAD3 protein modified form affects the susceptibility to salvianolic acid B
|
CTD |
PMID:33290806 |
|
NCBI chr 8:73,022,204...73,132,324
Ensembl chr 8:64,110,039...64,236,960
|
|
G
|
Sod1
|
superoxide dismutase 1
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SOD1 protein]
|
CTD |
PMID:33994527 |
|
NCBI chr11:42,942,742...42,948,399
Ensembl chr11:29,456,558...29,462,249
|
|
G
|
Sod2
|
superoxide dismutase 2
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of SOD2 protein]
|
CTD |
PMID:24769256 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
|
|
G
|
Tfam
|
transcription factor A, mitochondrial
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TFAM mRNA]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of TFAM protein]
|
CTD |
PMID:33994527 |
|
NCBI chr20:17,355,373...17,367,422
Ensembl chr20:17,356,197...17,368,292
|
|
G
|
Tgfb1
|
transforming growth factor, beta 1
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFB1 protein]; salvianolic acid B inhibits the reaction [TGFB1 protein results in increased expression of COL1A2 mRNA] salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TGFB1 mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TGFB1 protein] salvianolic acid B affects the reaction [TGFB1 protein affects the reaction [SMAD3 protein mutant form affects the expression of CDKN1A protein]]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TGFB1 protein]
|
CTD |
PMID:16009107 PMID:19474275 PMID:33290806 PMID:35795853 |
|
NCBI chr 1:90,324,312...90,340,627
Ensembl chr 1:81,196,532...81,212,847
|
|
G
|
Tgfbr1
|
transforming growth factor, beta receptor 1
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR1 protein]
|
CTD |
PMID:16009107 |
|
NCBI chr 5:66,449,348...66,506,371
Ensembl chr 5:61,653,233...61,710,777
|
|
G
|
Tgfbr2
|
transforming growth factor, beta receptor 2
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Dimethylnitrosamine results in increased expression of TGFBR2 protein]
|
CTD |
PMID:16009107 |
|
NCBI chr 8:124,672,677...124,761,741
Ensembl chr 8:115,794,537...115,883,228
|
|
G
|
Tlr4
|
toll-like receptor 4
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 mRNA]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TLR4 protein] salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TLR4 protein] salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TLR4 mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TLR4 protein]
|
CTD |
PMID:22101700 PMID:35795853 |
|
NCBI chr 5:85,161,247...85,174,882
Ensembl chr 5:80,145,826...80,159,628
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
EXP ISO
|
salvianolic acid B inhibits the reaction [Ethanol results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [Thioacetamide results in increased expression of TNF protein] salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TNF protein] NFE2L2 protein affects the reaction [salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; salvianolic acid B inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TNF mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TNF protein]; salvianolic acid B inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]
|
CTD |
PMID:19822164 PMID:22101700 PMID:24769256 PMID:24991814 PMID:27989594 PMID:35795853 More...
|
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G
|
Tp53
|
tumor protein p53
|
decreases acetylation multiple interactions
|
ISO EXP
|
salvianolic acid B results in decreased acetylation of TP53 protein salvianolic acid B inhibits the reaction [Ethanol results in increased acetylation of TP53 protein]
|
CTD |
PMID:24769256 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
|
|
G
|
Traf6
|
TNF receptor associated factor 6
|
multiple interactions
|
ISO
|
salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TRAF6 mRNA]; salvianolic acid B inhibits the reaction [[Air Pollutants results in increased abundance of Particulate Matter] which results in increased expression of TRAF6 protein]
|
CTD |
PMID:35795853 |
|
NCBI chr 3:108,418,537...108,443,330
Ensembl chr 3:87,963,514...87,983,507
|
|
G
|
Trpc3
|
transient receptor potential cation channel, subfamily C, member 3
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC3 protein]
|
CTD |
PMID:28495616 |
|
NCBI chr 2:119,481,313...119,619,333
Ensembl chr 2:119,481,400...119,558,855
|
|
G
|
Trpc6
|
transient receptor potential cation channel, subfamily C, member 6
|
multiple interactions
|
EXP
|
salvianolic acid B inhibits the reaction [Doxorubicin results in increased expression of TRPC6 protein]
|
CTD |
PMID:28495616 |
|
NCBI chr 8:14,044,216...14,148,808
Ensembl chr 8:5,758,935...5,828,092
|
|
|
G
|
Acsl4
|
acyl-CoA synthetase long-chain family member 4
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of ACSL4 protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr X:110,739,633...110,803,416
Ensembl chr X:105,942,799...106,006,427
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G
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Acta2
|
actin alpha 2, smooth muscle
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of ACTA2 mRNA]]
|
CTD |
PMID:38992766 |
|
NCBI chr 1:241,159,723...241,172,503
Ensembl chr 1:231,746,548...231,759,554
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G
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Amotl1
|
angiomotin-like 1
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multiple interactions decreases response to substance
|
ISO
|
Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein] Verteporfin results in decreased susceptibility to AMOTL1 protein
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CTD |
PMID:34480788 |
|
NCBI chr 8:11,348,651...11,467,564
Ensembl chr 8:11,353,674...11,467,573
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G
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Ankrd1
|
ankyrin repeat domain 1
|
multiple interactions decreases expression
|
ISO
|
verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA] [calcipotriene co-treated with Verteporfin] promotes the reaction [Carbon Tetrachloride results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of ANKRD1 mRNA]; Verteporfin promotes the reaction [Carbon Tetrachloride results in increased expression of ANKRD1 mRNA] verteporfin results in decreased expression of ANKRD1 mRNA
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CTD |
PMID:29725256 PMID:29893953 PMID:38992766 |
|
NCBI chr 1:233,815,851...233,834,891
Ensembl chr 1:233,815,851...233,834,919
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G
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Bax
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BCL2 associated X, apoptosis regulator
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of BAX protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G
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Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of BCL2 protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G
|
Birc5
|
baculoviral IAP repeat-containing 5
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of BIRC5 mRNA]
|
CTD |
PMID:29893953 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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G
|
Casp9
|
caspase 9
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of and results in increased cleavage of CASP9 protein]]
|
CTD |
PMID:35093381 |
|
Ensembl chr 5:154,109,046...154,126,626
|
|
G
|
Ccl2
|
C-C motif chemokine ligand 2
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL2 protein]
|
CTD |
PMID:31812773 |
|
NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G
|
Ccl5
|
C-C motif chemokine ligand 5
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CCL5 protein]
|
CTD |
PMID:31812773 |
|
NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G
|
Ccn1
|
cellular communication network factor 1
|
multiple interactions decreases expression
|
ISO
|
Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA] Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCN1 mRNA] Verteporfin results in decreased expression of CCN1 mRNA
|
CTD |
PMID:29725256 PMID:29893953 |
|
NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484
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G
|
Ccn2
|
cellular communication network factor 2
|
decreases expression multiple interactions
|
ISO
|
Verteporfin results in decreased expression of CCN2 mRNA [calcipotriene co-treated with Verteporfin] promotes the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA]; Verteporfin inhibits the reaction [[XMU-MP-1 co-treated with Cadmium Chloride] results in increased expression of CCN2 mRNA]; Verteporfin promotes the reaction [Carbon Tetrachloride results in increased expression of CCN2 mRNA] Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA]
|
CTD |
PMID:29725256 PMID:35027733 PMID:38992766 |
|
NCBI chr 1:22,621,498...22,624,614
Ensembl chr 1:20,802,199...20,805,734
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G
|
Ccna2
|
cyclin A2
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNA2 mRNA]
|
CTD |
PMID:29893953 |
|
NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G
|
Ccnb1
|
cyclin B1
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CCNB1 mRNA]
|
CTD |
PMID:29893953 |
|
NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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|
G
|
Cdc20
|
cell division cycle 20
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with calcipotriene] inhibits the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of CDC20 mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr 5:137,251,596...137,255,799
Ensembl chr 5:131,966,215...131,970,512
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|
G
|
Cdc6
|
cell division cycle 6
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of CDC6 mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of CDC6 mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr10:84,360,361...84,374,239
Ensembl chr10:83,864,638...83,878,011
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|
G
|
Cma1
|
chymase 1
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CMA1 protein]
|
CTD |
PMID:31812773 |
|
NCBI chr15:33,387,351...33,390,133
Ensembl chr15:29,417,451...29,420,233
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|
G
|
Cnn2
|
calponin 2
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of CNN2 mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of CNN2 mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr 7:10,363,141...10,370,312
Ensembl chr 7:9,712,516...9,719,656
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|
G
|
Col1a1
|
collagen type I alpha 1 chain
|
multiple interactions
|
ISO
|
[calcipotriene co-treated with Verteporfin] inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]; Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of COL1A1 mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr10:80,380,458...80,397,461
Ensembl chr10:79,883,622...79,900,624
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|
G
|
Csf3
|
colony stimulating factor 3
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of CSF3 protein]
|
CTD |
PMID:31812773 |
|
NCBI chr10:84,157,485...84,159,860
Ensembl chr10:83,661,207...83,663,603
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|
G
|
Cyp2b3
|
cytochrome P450, family 2, subfamily b, polypeptide 3
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2B10 mRNA]
|
CTD |
PMID:29893953 |
|
NCBI chr 1:90,780,468...90,859,852
Ensembl chr 1:81,652,787...81,732,143
|
|
G
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Cyp2c24
|
cytochrome P450, family 2, subfamily c, polypeptide 24
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of CYP2C55 mRNA]
|
CTD |
PMID:29893953 |
|
NCBI chr 1:236,873,967...236,936,238
Ensembl chr 1:236,873,967...236,936,238
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|
G
|
Fundc1
|
FUN14 domain containing 1
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of FUNDC1 protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr X:5,083,635...5,100,293
Ensembl chr X:5,083,617...5,100,284
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|
G
|
Gclc
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glutamate-cysteine ligase, catalytic subunit
|
decreases expression
|
ISO
|
Verteporfin results in decreased expression of GCLC protein
|
CTD |
PMID:37832483 |
|
NCBI chr 8:87,510,251...87,548,896
Ensembl chr 8:78,630,127...78,668,544
|
|
G
|
Gpt
|
glutamic--pyruvic transaminase
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of GPT protein]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein]
|
CTD |
PMID:38992766 |
|
NCBI chr 7:110,295,599...110,300,134
Ensembl chr 7:108,416,642...108,419,494
|
|
G
|
Gpx4
|
glutathione peroxidase 4
|
multiple interactions decreases expression
|
EXP ISO
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of GPX4 protein]] Verteporfin results in decreased expression of GPX4 protein
|
CTD |
PMID:35093381 PMID:37832483 |
|
NCBI chr 7:9,650,186...9,652,982
Ensembl chr 7:9,650,185...9,652,982
|
|
G
|
Gsr
|
glutathione-disulfide reductase
|
decreases expression
|
ISO
|
Verteporfin results in decreased expression of GSR protein
|
CTD |
PMID:37832483 |
|
NCBI chr16:65,185,574...65,228,742
Ensembl chr16:58,482,505...58,525,661
|
|
G
|
Hmmr
|
hyaluronan-mediated motility receptor
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [calcipotriene promotes the reaction [Carbon Tetrachloride results in increased expression of HMMR mRNA]]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of HMMR mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr10:25,635,249...25,665,389
Ensembl chr10:25,132,977...25,163,060
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|
G
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Hmox1
|
heme oxygenase 1
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increases expression
|
ISO
|
verteporfin results in increased expression of HMOX1 protein
|
CTD |
PMID:16462769 |
|
NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
|
|
G
|
Il11
|
interleukin 11
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of IL11 mRNA]; Verteporfin promotes the reaction [calcipotriene inhibits the reaction [Carbon Tetrachloride results in increased expression of IL11 mRNA]]
|
CTD |
PMID:38992766 |
|
NCBI chr 1:78,098,622...78,104,915
Ensembl chr 1:69,068,137...69,076,129
|
|
G
|
Il6
|
interleukin 6
|
multiple interactions
|
ISO
|
[EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA] Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein]
|
CTD |
PMID:31812773 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
|
|
G
|
Iqgap3
|
IQ motif containing GTPase activating protein 3
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with calcipotriene] inhibits the reaction [Carbon Tetrachloride results in increased expression of IQGAP3 mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of IQGAP3 mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr 2:173,542,151...173,583,956
Ensembl chr 2:173,542,110...173,583,956
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|
G
|
Jak1
|
Janus kinase 1
|
multiple interactions decreases expression
|
ISO
|
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK1 protein Verteporfin results in decreased expression of JAK1 protein
|
CTD |
PMID:31812773 |
|
NCBI chr 5:120,895,606...121,004,207
Ensembl chr 5:115,780,248...115,888,926
|
|
G
|
Jak2
|
Janus kinase 2
|
decreases expression multiple interactions
|
ISO
|
Verteporfin results in decreased expression of JAK2 protein [Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of JAK2 protein
|
CTD |
PMID:31812773 |
|
NCBI chr 1:236,408,905...236,468,769
Ensembl chr 1:226,995,334...227,054,189
|
|
G
|
Mcm2
|
minichromosome maintenance complex component 2
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [1,4-bis(2-(3,5-dichloropyridyloxy))benzene results in increased expression of MCM2 mRNA]
|
CTD |
PMID:29893953 |
|
NCBI chr 4:122,903,679...122,918,205
Ensembl chr 4:121,346,434...121,360,847
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of MKI67 mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of MKI67 mRNA]; Verteporfin inhibits the reaction [perfluorooctanoic acid results in increased expression of MKI67 protein]
|
CTD |
PMID:36152675 PMID:38992766 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:190,496,319...190,522,762
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|
G
|
Mt1
|
metallothionein 1
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]
|
CTD |
PMID:35027733 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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|
G
|
Mt2
|
metallothionein 2
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with XMU-MP-1] promotes the reaction [Cadmium Chloride results in increased expression of MT2 mRNA]
|
CTD |
PMID:35027733 |
|
NCBI chr19:10,837,934...10,838,708
Ensembl chr19:10,832,002...10,832,784
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G
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Nppb
|
natriuretic peptide B
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased expression of NPPB protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr 5:163,699,955...163,701,314
Ensembl chr 5:158,416,866...158,418,168
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|
G
|
Opa1
|
OPA1, mitochondrial dynamin like GTPase
|
multiple interactions
|
EXP
|
Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in decreased expression of OPA1 protein]]
|
CTD |
PMID:35093381 |
|
NCBI chr11:84,612,943...84,690,025
Ensembl chr11:71,109,873...71,185,109
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
increases cleavage
|
ISO
|
Verteporfin results in increased cleavage of PARP1 protein
|
CTD |
PMID:31494105 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Rasal2
|
RAS protein activator like 2
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein]
|
CTD |
PMID:34826200 |
|
NCBI chr13:69,279,882...69,569,161
Ensembl chr13:69,258,622...69,569,940
|
|
G
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Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with lipopolysaccharide, Escherichia coli O111 B4] results in decreased expression of RELA protein; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of and results in increased phosphorylation of RELA protein]
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CTD |
PMID:31812773 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
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G
|
Stat1
|
signal transducer and activator of transcription 1
|
decreases expression multiple interactions
|
ISO
|
Verteporfin results in decreased expression of STAT1 protein Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT1 protein]
|
CTD |
PMID:31812773 |
|
NCBI chr 9:56,911,522...56,951,926
Ensembl chr 9:49,419,340...49,588,540
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|
G
|
Stat3
|
signal transducer and activator of transcription 3
|
multiple interactions decreases expression
|
ISO
|
Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of and results in increased phosphorylation of STAT3 protein] Verteporfin results in decreased expression of STAT3 protein
|
CTD |
PMID:31812773 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:85,811,218...85,863,057
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|
G
|
Tead1
|
TEA domain transcription factor 1
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
|
CTD |
PMID:29893953 |
|
NCBI chr 1:166,791,900...167,010,591
Ensembl chr 1:166,792,628...167,003,369
|
|
G
|
Timp1
|
TIMP metallopeptidase inhibitor 1
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with Carbon Tetrachloride] results in increased expression of TIMP1 mRNA; Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of TIMP1 mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr X:3,766,509...3,772,578
Ensembl chr X:1,212,972...1,217,664
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions
|
ISO
|
Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] [EVP 4593 co-treated with Verteporfin] inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; Verteporfin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]
|
CTD |
PMID:31812773 PMID:38992766 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
|
|
G
|
Top2a
|
DNA topoisomerase II alpha
|
multiple interactions
|
ISO
|
[Verteporfin co-treated with calcipotriene] inhibits the reaction [Carbon Tetrachloride results in increased expression of TOP2A mRNA]; Verteporfin inhibits the reaction [[calcipotriene co-treated with Carbon Tetrachloride] results in increased expression of TOP2A mRNA]; Verteporfin inhibits the reaction [Carbon Tetrachloride results in increased expression of TOP2A mRNA]
|
CTD |
PMID:38992766 |
|
NCBI chr10:84,441,954...84,473,093
Ensembl chr10:83,945,735...83,976,874
|
|
G
|
Yap1
|
Yes1 associated transcriptional regulator
|
multiple interactions decreases expression decreases activity
|
ISO EXP
|
Verteporfin inhibits the reaction [AMOTL1 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [RASAL2 protein results in increased activity of YAP1 protein]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of ANKRD1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN1 mRNA]; Verteporfin inhibits the reaction [YAP1 protein results in increased expression of CCN2 mRNA] Verteporfin inhibits the reaction [Melatonin inhibits the reaction [Doxorubicin results in increased phosphorylation of YAP1 protein]] Verteporfin results in decreased expression of YAP1 protein Verteporfin results in decreased activity of YAP1 protein Verteporfin inhibits the reaction [YAP1 protein binds to TEAD1 protein]
|
CTD |
PMID:29725256 PMID:29893953 PMID:31494105 PMID:34351699 PMID:34480788 PMID:34826200 PMID:35093381 More...
|
|
NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010
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|
|
G
|
Abcb11
|
ATP binding cassette subfamily B member 11
|
affects localization decreases activity multiple interactions
|
EXP ISO
|
wortmannin affects the localization of ABCB11 protein wortmannin results in decreased activity of ABCB11 protein wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCB11 protein]
|
CTD |
PMID:12702492 PMID:20815017 PMID:20829430 PMID:23956101 |
|
NCBI chr 3:74,424,620...74,520,646
Ensembl chr 3:54,017,127...54,112,730
|
|
G
|
Abcc2
|
ATP binding cassette subfamily C member 2
|
affects localization multiple interactions
|
EXP
|
wortmannin affects the localization of ABCC2 protein Wortmannin inhibits the reaction [estradiol-17 beta-glucuronide affects the localization of ABCC2 protein]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in decreased activity of and affects the localization of ABCC2 protein]
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CTD |
PMID:12702492 PMID:20815017 PMID:31300867 |
|
NCBI chr 1:252,613,875...252,672,459
Ensembl chr 1:242,664,657...242,723,238
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G
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Acox1
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acyl-CoA oxidase 1
|
multiple interactions
|
EXP
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wortmannin inhibits the reaction [bisphenol A results in decreased expression of ACOX1 mRNA]
|
CTD |
PMID:23399309 |
|
NCBI chr10:101,905,083...101,930,136
Ensembl chr10:101,406,197...101,431,232
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G
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Agt
|
angiotensinogen
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multiple interactions
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EXP
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Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:15121739 PMID:15849355 PMID:25398788 |
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NCBI chr19:69,426,540...69,447,017
Ensembl chr19:52,529,185...52,540,977
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G
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Ahr
|
aryl hydrocarbon receptor
|
multiple interactions
|
EXP
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Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA]
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CTD |
PMID:26466350 |
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NCBI chr 6:57,961,423...57,998,901
Ensembl chr 6:52,234,089...52,271,568
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G
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Aifm1
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apoptosis inducing factor, mitochondria associated 1
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decreases localization
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EXP
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wortmannin results in decreased localization of AIFM1 protein
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CTD |
PMID:21256120 |
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NCBI chr X:132,528,107...132,567,237
Ensembl chr X:127,650,226...127,689,256
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G
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Akt1
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AKT serine/threonine kinase 1
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multiple interactions decreases expression decreases reaction decreases phosphorylation decreases activity
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ISO EXP
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AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; Wortmannin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [baicalein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [bisphenol AF results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Caffeine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Copper results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [CXCL8 results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Hexanones results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Humic Substances results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Hydrocarbons, Chlorinated results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [ochratoxin A results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Oxygen deficiency results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Nifedipine co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Trp-Lys-Tyr-Met-Val-Met results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin promotes the reaction [evodiamine results in decreased phosphorylation of AKT1 protein] [wortmannin cotreatment with isoflurane] decreases expression of AKT1 mRNA,protein in hippocampus Wortmannin inhibits the reaction [ethanol increases phosphorylation of Akt1 protein in cardiac muscle cells] Wortmannin inhibits the reaction [Insulin increases activity of Akt1 protein in adipocytes] wortmannin inhibits the reaction [estrogen increases phosphorylation of Akt1 protein] in rat uterus wortmannin results in decreased phosphorylation of AKT1 protein Resveratrol promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Thimerosal promotes the reaction [Wortmannin results in decreased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Isoproterenol results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [zinc chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Melatonin inhibits the reaction [S-Nitroso-N-Acetylpenicillamine results in decreased phosphorylation of AKT1 protein]]; Wortmannin promotes the reaction [Resveratrol results in decreased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [Thimerosal results in decreased phosphorylation of AKT1 protein]; Wortmannin results in decreased activity of and results in decreased phosphorylation of AKT1 protein wortmannin results in decreased expression of AKT1 protein Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [AGT protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [astringin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Carbon Tetrachloride results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [hydroxyflutamide results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [linsidomine results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Mevinphos results in increased activity of and results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Peroxynitrous Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of AKT1 mRNA]]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Taurocholic Acid inhibits the reaction [Carbon Tetrachloride results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [Taurolithocholic Acid results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Thapsigargin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Tunicamycin results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of AKT1 protein] wortmannin results in decreased activity of AKT1 protein
|
CTD RGD |
PMID:11306697 PMID:11340092 PMID:11788791 PMID:12032135 PMID:12388182 PMID:12482858 PMID:12556562 PMID:12614848 PMID:12640124 PMID:14757120 PMID:15050414 PMID:15177934 PMID:15178407 PMID:15355987 PMID:15608143 PMID:15695173 PMID:15845746 PMID:15849355 PMID:15980035 PMID:16059913 PMID:16116186 PMID:16224792 PMID:16499871 PMID:16682453 PMID:16825486 PMID:16973122 PMID:17129604 PMID:17302912 PMID:17324588 PMID:17346750 PMID:17464197 PMID:17513037 PMID:17520698 PMID:17550345 PMID:17728140 PMID:17962351 PMID:18025287 PMID:18040759 PMID:18201823 PMID:18317400 PMID:18591783 PMID:18948619 PMID:19139269 PMID:19686714 PMID:19801633 PMID:19810018 PMID:20005289 PMID:20100827 PMID:20153296 PMID:20562903 PMID:20880397 PMID:21138475 PMID:21195169 PMID:21742513 PMID:21767602 PMID:21820214 PMID:22022464 PMID:22137261 PMID:22556157 PMID:23001822 PMID:23145070 PMID:23178381 PMID:24024143 PMID:24462917 PMID:24748653 PMID:25002221 PMID:25398788 PMID:25461906 PMID:25603053 PMID:25663935 PMID:26262998 PMID:26437446 PMID:26887316 PMID:28759639 PMID:30542433 PMID:30590302 PMID:30851366 PMID:31173752 PMID:31300867 PMID:31445927 PMID:32802178 PMID:32805344 PMID:33582643 PMID:34077701 PMID:34144024 PMID:35066937 PMID:36288207 PMID:37051183 PMID:30221701 PMID:15217794 PMID:9065430 PMID:17272396 More...
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RGD:597931096, RGD:408346755, RGD:407420264, RGD:152177689 |
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:131,713,720...131,733,921
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G
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Akt1s1
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AKT1 substrate 1
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multiple interactions decreases phosphorylation
|
ISO
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wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein] wortmannin results in decreased phosphorylation of AKT1S1 protein
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CTD |
PMID:20880397 |
|
NCBI chr 1:95,333,186...95,339,678
Ensembl chr 1:95,332,898...95,339,677
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G
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Alpi
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alkaline phosphatase, intestinal
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multiple interactions increases activity
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ISO
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wortmannin promotes the reaction [Methotrexate results in increased activity of ALPI protein] wortmannin results in increased activity of ALPI protein
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CTD |
PMID:16598758 |
|
NCBI chr 9:95,221,314...95,224,780
Ensembl chr 9:87,773,411...87,776,877
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G
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Apob
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apolipoprotein B
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multiple interactions
|
EXP
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wortmannin inhibits the reaction [[bisphenol A results in decreased expression of APOB mRNA] which results in decreased abundance of Triglycerides]; wortmannin inhibits the reaction [bisphenol A results in decreased expression of APOB mRNA]
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CTD |
PMID:23399309 |
|
NCBI chr 6:30,844,386...30,883,983
Ensembl chr 6:30,844,368...30,892,497
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G
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App
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amyloid beta precursor protein
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increases expression
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EXP
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[wortmannin cotreatment with isoflurane] increases expression of APP protein in hippocampus
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RGD |
PMID:30221701 |
RGD:597931096 |
NCBI chr11:37,506,207...37,724,351
Ensembl chr11:24,019,778...24,236,561
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|
G
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Areg
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amphiregulin
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decreases activity
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EXP
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wortmannin results in decreased activity of AREG protein
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CTD |
PMID:12589827 |
|
NCBI chr14:17,256,384...17,265,641
Ensembl chr14:16,972,187...16,981,535
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G
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Arnt
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aryl hydrocarbon receptor nuclear translocator
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multiple interactions
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EXP
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wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]
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CTD |
PMID:26466350 |
|
NCBI chr 2:182,997,731...183,056,584
Ensembl chr 2:182,997,736...183,056,580
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G
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Atf2
|
activating transcription factor 2
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multiple interactions
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EXP
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Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of ATF2 protein]
|
CTD |
PMID:10611455 |
|
NCBI chr 3:79,125,814...79,202,896
Ensembl chr 3:58,718,332...58,795,236
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G
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Atm
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ATM serine/threonine kinase
|
multiple interactions
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ISO
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wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of ATM protein] ATM protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]
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CTD |
PMID:15489221 PMID:20888899 PMID:22119920 |
|
NCBI chr 8:62,724,939...62,829,040
Ensembl chr 8:53,831,093...53,932,437
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G
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Bace1
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beta-secretase 1
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increases expression
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EXP
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[wortmannin cotreatment with isoflurane] increases expression of Bace1 mRNA, protein in hippocampus
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RGD |
PMID:30221701 |
RGD:597931096 |
NCBI chr 8:46,142,060...46,166,268
Ensembl chr 8:46,142,116...46,165,876
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G
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Bad
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BCL2-associated agonist of cell death
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multiple interactions decreases phosphorylation
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ISO EXP
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wortmannin inhibits the reaction [Acrolein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein] wortmannin results in decreased phosphorylation of BAD protein Wortmannin inhibits the reaction [Mannitol results in increased phosphorylation of BAD protein]; Wortmannin inhibits the reaction [ursodoxicoltaurine results in increased phosphorylation of and affects the localization of BAD protein]
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CTD |
PMID:15190125 PMID:15608143 PMID:15786717 PMID:19596284 |
|
NCBI chr 1:213,562,719...213,572,034
Ensembl chr 1:204,131,501...204,142,823
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G
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Bax
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BCL2 associated X, apoptosis regulator
|
multiple interactions
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ISO EXP
|
Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased expression of BAX protein]]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of BAX protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein]] Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of BAX protein]]
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CTD |
PMID:15142122 PMID:15970427 PMID:31173752 PMID:32805344 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:95,938,808...95,945,368
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G
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Bcar1
|
BCAR1 scaffold protein, Cas family member
|
multiple interactions
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ISO
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[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of BCAR1 protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of BCAR1 protein]
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CTD |
PMID:10537051 |
|
NCBI chr19:39,679,215...39,713,907
Ensembl chr19:39,679,204...39,713,907
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|
G
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Bcl2
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BCL2, apoptosis regulator
|
multiple interactions
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ISO EXP
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Wortmannin inhibits the reaction [[Hydrogen Peroxide co-treated with Arsenic Trioxide] results in decreased expression of BCL2 protein]; Wortmannin inhibits the reaction [Ethanol results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of BCL2 protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein]] Wortmannin inhibits the reaction [[1,1-dimethylbutyl-1-deoxy-Delta(9)-THC co-treated with Magnesium deficiency] results in increased expression of BCL2 protein]; Wortmannin inhibits the reaction [Propofol results in increased expression of BCL2 protein]
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CTD |
PMID:15142122 PMID:19703415 PMID:21410490 PMID:30542433 PMID:31173752 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G
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Bcl2l1
|
Bcl2-like 1
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [arsenic trioxide results in decreased expression of BCL2L1 protein]]
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CTD |
PMID:15142122 |
|
NCBI chr 3:161,713,777...161,764,844
Ensembl chr 3:141,253,523...141,303,479 Ensembl chr 1:141,253,523...141,303,479
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|
G
|
Bdnf
|
brain-derived neurotrophic factor
|
multiple interactions
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ISO EXP
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wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein] Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of BDNF protein]]
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CTD |
PMID:17209049 PMID:32805344 |
|
NCBI chr 3:116,619,633...116,670,212
Ensembl chr 3:96,165,042...96,215,615
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G
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Becn1
|
beclin 1
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multiple interactions decreases expression
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ISO EXP
|
wortmannin promotes the reaction [Ethanol results in increased degradation of BECN1 protein] wortmannin inhibits the reaction [manganese chloride results in increased expression of BECN1 protein] wortmannin results in decreased expression of BECN1 protein
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CTD |
PMID:21410490 PMID:23604964 |
|
NCBI chr10:86,731,649...86,747,002
Ensembl chr10:86,231,388...86,246,742
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|
G
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Birc2
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baculoviral IAP repeat-containing 2
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multiple interactions decreases expression
|
ISO
|
wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC2 protein] wortmannin results in decreased expression of BIRC2 mRNA; wortmannin results in decreased expression of BIRC2 protein
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CTD |
PMID:15065019 PMID:19596284 |
|
NCBI chr 8:4,968,856...4,989,325
Ensembl chr 8:4,968,842...4,988,732
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|
G
|
Birc3
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baculoviral IAP repeat-containing 3
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Acrolein results in increased expression of BIRC3 protein]
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CTD |
PMID:19596284 |
|
NCBI chr 8:5,000,844...5,028,470
Ensembl chr 8:5,000,845...5,015,802
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|
G
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Birc5
|
baculoviral IAP repeat-containing 5
|
decreases expression multiple interactions
|
ISO
|
wortmannin results in decreased expression of BIRC5 mRNA; wortmannin results in decreased expression of BIRC5 protein wortmannin promotes the reaction [baicalein results in decreased expression of BIRC5 protein] wortmannin promotes the reaction [resveratrol results in decreased expression of BIRC5 protein]
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CTD |
PMID:15065019 PMID:18025287 PMID:22137261 PMID:23145070 |
|
NCBI chr10:103,567,369...103,580,069
Ensembl chr10:103,073,408...103,081,380
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|
G
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C5
|
complement C5
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]; wortmannin inhibits the reaction [C5 protein results in increased phosphorylation of AKT1 protein]
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CTD |
PMID:16116186 |
|
NCBI chr 3:38,668,174...38,759,468
Ensembl chr 3:18,270,696...18,361,994
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|
G
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Casp1
|
caspase 1
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increases cleavage
|
ISO
|
wortmannin results in increased cleavage of CASP1 protein
|
CTD |
PMID:26847702 |
|
NCBI chr 8:10,746,338...10,882,295
Ensembl chr 8:2,587,831...2,597,383
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G
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Casp3
|
caspase 3
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multiple interactions increases expression increases cleavage decreases activity
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ISO EXP
|
ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]]; AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide inhibits the reaction [Arsenic Trioxide results in increased activity of CASP3 protein]]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased cleavage of CASP3 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP3 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of and results in increased activity of CASP3 protein]; Wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP3 protein] [wortmannin cotreatment with isoflurane] increases expression of caspase3 mRNA,protein in hippocampus wortmannin results in increased cleavage of CASP3 protein [Rotenone co-treated with wortmannin] results in increased cleavage of CASP3 protein; Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [resveratrol results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP3 protein]; wortmannin promotes the reaction [wortmannin results in increased cleavage of CASP3 protein] wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP3 protein] wortmannin results in decreased activity of CASP3 protein
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CTD RGD |
PMID:15142122 PMID:15695173 PMID:17935137 PMID:20104024 PMID:21256120 PMID:22137261 PMID:23145070 PMID:24726520 PMID:25002221 PMID:25603053 PMID:26847702 PMID:31173752 PMID:32802178 PMID:30221701 More...
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RGD:597931096 |
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:45,662,910...45,684,648
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G
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Casp7
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caspase 7
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multiple interactions
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ISO
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wortmannin promotes the reaction [ochratoxin A results in increased activity of CASP7 protein]
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CTD |
PMID:25002221 |
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NCBI chr 1:265,442,647...265,481,938
Ensembl chr 1:255,437,172...255,476,729
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G
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Casp8
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caspase 8
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multiple interactions
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ISO EXP
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ABT-737 promotes the reaction [wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein]]; wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP8 protein] wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP8 protein]
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CTD |
PMID:20104024 PMID:24726520 |
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NCBI chr 9:67,747,109...67,806,699
Ensembl chr 9:60,264,075...60,312,542
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G
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Casp9
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caspase 9
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multiple interactions increases cleavage
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ISO EXP
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ABT-737 promotes the reaction [Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]]; Wortmannin promotes the reaction [Celecoxib results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of CASP9 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of CASP9 protein] wortmannin results in increased cleavage of CASP9 protein Thimerosal promotes the reaction [wortmannin results in increased cleavage of CASP9 protein]; wortmannin promotes the reaction [Thimerosal results in increased cleavage of CASP9 protein] wortmannin inhibits the reaction [2,4,5,2',4',5'-hexachlorobiphenyl results in decreased activity of CASP9 protein]
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CTD |
PMID:17935137 PMID:20104024 PMID:22137261 PMID:23145070 PMID:24726520 |
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Ensembl chr 5:154,109,046...154,126,626
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G
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Cav1
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caveolin 1
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multiple interactions
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ISO
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wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to Hydrogen Peroxide]; wortmannin inhibits the reaction [CAV1 protein results in increased susceptibility to sodium arsenite]
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CTD |
PMID:12640124 |
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NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:45,634,918...45,673,705
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G
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Ccl2
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C-C motif chemokine ligand 2
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL2 mRNA]
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CTD |
PMID:22225513 |
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NCBI chr10:67,503,077...67,504,875
Ensembl chr10:67,005,424...67,007,226
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G
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Ccl5
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C-C motif chemokine ligand 5
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multiple interactions
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ISO
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wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]; wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of CCL5 mRNA]
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CTD |
PMID:19016906 PMID:22225513 |
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NCBI chr10:68,820,330...68,824,906
Ensembl chr10:68,322,829...68,327,377
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G
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Ccna2
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cyclin A2
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Vanadates results in increased expression of CCNA2 protein]
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CTD |
PMID:14971663 |
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NCBI chr 2:121,355,363...121,361,762
Ensembl chr 2:119,426,089...119,433,577
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G
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Ccnb1
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cyclin B1
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multiple interactions
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ISO
|
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]
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CTD |
PMID:26385184 |
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NCBI chr 2:33,646,252...33,655,225
Ensembl chr 2:31,912,193...31,921,172
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G
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Ccnd1
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cyclin D1
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multiple interactions decreases expression
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ISO EXP
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Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CCND1 mRNA]; Wortmannin inhibits the reaction [7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of CCND1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 protein] Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CCND1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of CCND1 mRNA] Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased expression of CCND1 protein]]; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased expression of CCND1 protein] wortmannin results in decreased expression of CCND1 protein
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CTD |
PMID:15695173 PMID:18353414 PMID:19801633 PMID:28321046 PMID:30542433 PMID:33582643 PMID:36190352 PMID:36288207 PMID:37992829 More...
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NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:200,089,002...200,098,602
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G
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Ccnd2
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cyclin D2
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decreases methylation increases expression
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ISO
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wortmannin results in decreased methylation of CCND2 promoter wortmannin results in increased expression of CCND2 mRNA
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CTD |
PMID:14745455 |
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NCBI chr 4:161,653,048...161,675,422
Ensembl chr 4:159,962,363...159,989,495
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G
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Ccnd3
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cyclin D3
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affects localization multiple interactions
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ISO
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wortmannin affects the localization of CCND3 protein [wortmannin co-treated with Imatinib Mesylate] affects the localization of CCND3 protein; wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]
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CTD |
PMID:10849422 PMID:17129604 |
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NCBI chr 9:20,891,696...20,987,199
Ensembl chr 9:13,394,169...13,489,371
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G
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Ccne1
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cyclin E1
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Vanadates results in increased expression of CCNE1 protein] [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]
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CTD |
PMID:14971663 PMID:26385184 |
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NCBI chr 1:99,918,672...99,927,986
Ensembl chr 1:90,781,949...90,791,101
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G
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Ccr3
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C-C motif chemokine receptor 3
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multiple interactions
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ISO
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wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]
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CTD |
PMID:11544337 |
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NCBI chr 8:123,586,100...123,634,178
Ensembl chr 8:123,616,236...123,634,990
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G
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Ccr5
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C-C motif chemokine receptor 5
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[CCL5 protein binds to and results in increased activity of CCR5 protein] which results in increased abundance of Nitric Oxide]
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CTD |
PMID:19016906 |
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NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260
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G
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Cd36
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CD36 molecule
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of CD36 mRNA]
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CTD |
PMID:19640849 |
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NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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G
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Cdc25a
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cell division cycle 25A
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multiple interactions decreases expression
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ISO
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Imatinib Mesylate promotes the reaction [wortmannin results in decreased expression of CDC25A protein]
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CTD |
PMID:17129604 |
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NCBI chr 8:118,742,824...118,761,190
Ensembl chr 8:109,864,478...109,882,701
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G
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Cdc5l
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cell division cycle 5-like
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multiple interactions
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EXP
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wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]
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CTD |
PMID:20629186 |
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NCBI chr 9:15,564,949...15,603,453
Ensembl chr 9:15,564,767...15,603,450
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G
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Cdh1
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cadherin 1
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increases expression
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ISO
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wortmannin results in increased expression of CDH1 protein
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CTD |
PMID:25856345 |
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NCBI chr19:51,402,178...51,471,572
Ensembl chr19:34,492,371...34,561,775
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G
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Cdh2
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cadherin 2
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multiple interactions
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ISO
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Wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CDH2 protein]; Wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CDH2 protein]
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CTD |
PMID:28163245 |
|
NCBI chr18:8,051,097...8,265,288
Ensembl chr18:7,776,704...7,990,167
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G
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Cdk1
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cyclin-dependent kinase 1
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multiple interactions
|
ISO
|
[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; wortmannin promotes the reaction [baicalein results in decreased phosphorylation of CDK1 protein]
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CTD |
PMID:18025287 PMID:26385184 |
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NCBI chr20:19,265,252...19,280,456
Ensembl chr20:19,266,248...19,281,408
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G
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Cdk2
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cyclin dependent kinase 2
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decreases activity multiple interactions decreases expression
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ISO
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wortmannin results in decreased activity of CDK2 protein [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [Cadmium Chloride results in increased expression of CDK2 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein] wortmannin results in decreased expression of CDK2 protein
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CTD |
PMID:17129604 PMID:26385184 |
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NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,129,811...1,137,403
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G
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Cdk4
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cyclin-dependent kinase 4
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multiple interactions
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ISO
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Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of CDK4 protein]
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CTD |
PMID:36288207 |
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NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:62,883,105...62,942,403
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G
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Cdkn1a
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cyclin-dependent kinase inhibitor 1A
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multiple interactions decreases expression increases expression
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ISO
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wortmannin inhibits the reaction [Aspirin results in increased expression of CDKN1A protein]; wortmannin inhibits the reaction [docetaxel results in increased expression of CDKN1A protein] wortmannin results in decreased expression of CDKN1A protein wortmannin results in increased expression of CDKN1A protein
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CTD |
PMID:15695173 PMID:17129604 PMID:20878124 PMID:21617849 PMID:22290291 |
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NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,149,217...7,159,585
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G
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Cdkn1b
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cyclin-dependent kinase inhibitor 1B
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multiple interactions increases expression
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ISO
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wortmannin promotes the reaction [Doxorubicin results in increased expression of CDKN1B protein]; wortmannin promotes the reaction [Etoposide results in increased expression of CDKN1B protein] Imatinib Mesylate promotes the reaction [wortmannin results in increased expression of CDKN1B protein]
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CTD |
PMID:17129604 PMID:17935137 |
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NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:167,760,181...167,764,982
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G
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Cftr
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CF transmembrane conductance regulator
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multiple interactions
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ISO
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wortmannin inhibits the reaction [CGP 12177 results in increased activity of CFTR protein]
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CTD |
PMID:15563584 |
|
NCBI chr 4:47,422,084...47,694,646
Ensembl chr 4:46,560,885...46,728,756
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G
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Chek1
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checkpoint kinase 1
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multiple interactions decreases expression
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ISO
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wortmannin inhibits the reaction [Carmustine results in increased phosphorylation of and results in increased activity of CHEK1 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK1 protein] wortmannin results in decreased expression of CHEK1 protein
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CTD |
PMID:19261750 PMID:22119920 PMID:22409540 |
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NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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G
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Chek2
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checkpoint kinase 2
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multiple interactions decreases phosphorylation
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ISO
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wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of CHEK2 protein]; wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of CHEK2 protein] wortmannin results in decreased phosphorylation of CHEK2 protein
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CTD |
PMID:19111594 PMID:22119920 |
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NCBI chr12:51,448,838...51,481,159
Ensembl chr12:45,788,827...45,821,286
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G
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Ckb
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creatine kinase B
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decreases reaction
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EXP
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wortmannin inhibits the reaction [estrogen increases expression of Ckb mRNA] in rat uterus
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RGD |
PMID:17272396 |
RGD:152177689 |
NCBI chr 6:136,550,583...136,553,464
Ensembl chr 6:130,729,423...130,732,315
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G
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Clu
|
clusterin
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Zinc results in increased expression of CLU protein]
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CTD |
PMID:19288494 |
|
NCBI chr15:44,336,619...44,375,861
Ensembl chr15:40,174,617...40,200,315
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G
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Col18a1
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collagen type XVIII alpha 1 chain
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of COL18A1 protein]
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CTD |
PMID:13679210 |
|
NCBI chr20:11,474,104...11,582,593
Ensembl chr20:11,474,104...11,582,593
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G
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Col1a2
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collagen type I alpha 2 chain
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Acetaldehyde results in increased expression of COL1A2 mRNA]
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CTD |
PMID:11343241 |
|
NCBI chr 4:33,518,557...33,553,484
Ensembl chr 4:32,563,381...32,598,867
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G
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Cpt1a
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carnitine palmitoyltransferase 1A
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multiple interactions
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EXP
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wortmannin inhibits the reaction [bisphenol A results in decreased expression of CPT1A mRNA]
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CTD |
PMID:23399309 |
|
NCBI chr 1:209,993,881...210,056,329
Ensembl chr 1:200,565,613...200,627,055
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G
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Creb1
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cAMP responsive element binding protein 1
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multiple interactions
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ISO
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wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in increased phosphorylation of CREB1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein] wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of CREB1 protein]]
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CTD |
PMID:15608143 PMID:22952890 PMID:23626723 |
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NCBI chr 9:73,397,333...73,466,339
Ensembl chr 9:65,903,547...65,970,816
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G
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Crp
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C-reactive protein
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multiple interactions
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ISO
|
wortmannin inhibits the reaction [Dust analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Dust results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Particulate Matter results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions analog results in increased expression of CRP mRNA]; wortmannin inhibits the reaction [Vehicle Emissions results in increased expression of CRP mRNA]
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CTD |
PMID:16263508 |
|
NCBI chr13:87,694,062...87,695,978
Ensembl chr13:85,124,977...85,175,178
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G
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Csf2
|
colony stimulating factor 2
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]
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CTD |
PMID:23001822 |
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NCBI chr10:38,887,692...38,889,673
Ensembl chr10:38,386,945...38,389,199
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G
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Ctnnb1
|
catenin beta 1
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decreases expression increases phosphorylation multiple interactions
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ISO
|
wortmannin results in decreased expression of CTNNB1 protein wortmannin results in increased phosphorylation of CTNNB1 protein wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of CTNNB1 protein]; wortmannin inhibits the reaction [hydroxyflutamide results in decreased phosphorylation of CTNNB1 protein]; wortmannin inhibits the reaction [Testosterone results in decreased phosphorylation of CTNNB1 protein]
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CTD |
PMID:11739494 PMID:28163245 PMID:28321046 |
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NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:120,639,995...120,667,111
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G
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Cxcl1
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C-X-C motif chemokine ligand 1
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multiple interactions
|
EXP
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wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL1 protein]
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CTD |
PMID:20117814 |
|
NCBI chr14:17,193,364...17,195,143
Ensembl chr14:17,193,365...17,195,215
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G
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Cxcl2
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C-X-C motif chemokine ligand 2
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multiple interactions
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ISO EXP
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wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of BAD protein]; wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of CREB1 protein] wortmannin inhibits the reaction [resveratrol results in decreased activity of CXCL2 protein]
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CTD |
PMID:15608143 PMID:20117814 |
|
NCBI chr14:17,465,210...17,467,255
Ensembl chr14:17,181,062...17,183,075
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G
|
Cxcr2
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C-X-C motif chemokine receptor 2
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [CXCL8 protein results in increased activity of CXCR2 protein]
|
CTD |
PMID:12975484 |
|
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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G
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Cycs
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cytochrome c, somatic
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decreases secretion
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EXP
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wortmannin results in decreased secretion of CYCS protein
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CTD |
PMID:21256120 |
|
NCBI chr 4:80,982,667...80,984,767
Ensembl chr 4:79,651,378...79,654,054 Ensembl chr18:79,651,378...79,654,054
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G
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Cyp11a1
|
cytochrome P450, family 11, subfamily a, polypeptide 1
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]
|
CTD |
PMID:25253736 |
|
NCBI chr 8:67,318,665...67,330,196
Ensembl chr 8:58,404,669...58,434,338
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G
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Cyp1a1
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cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions
|
EXP ISO
|
wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA] [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1A1 mRNA]
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CTD |
PMID:26466350 PMID:29724254 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:58,096,077...58,102,125
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G
|
Cyp1a2
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cytochrome P450, family 1, subfamily a, polypeptide 2
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA]
|
CTD |
PMID:26466350 |
|
NCBI chr 8:66,971,261...66,978,149
Ensembl chr 8:58,075,367...58,082,312
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G
|
Cyp1b1
|
cytochrome P450, family 1, subfamily b, polypeptide 1
|
multiple interactions
|
EXP ISO
|
wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA] [Filipin co-treated with Chlorpromazine co-treated with Wortmannin] inhibits the reaction [Particulate Matter results in increased expression of CYP1B1 mRNA]
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CTD |
PMID:26466350 PMID:29724254 |
|
NCBI chr 6:21,093,927...21,103,091
Ensembl chr 6:15,342,344...15,350,917
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G
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Cyp2e1
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cytochrome P450, family 2, subfamily e, polypeptide 1
|
multiple interactions
|
EXP ISO
|
wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA] Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]
|
CTD |
PMID:11306697 PMID:22486562 |
|
NCBI chr 1:205,269,967...205,280,365
Ensembl chr 1:195,840,058...195,864,023
|
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G
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Ddit3
|
DNA-damage inducible transcript 3
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 mRNA]; wortmannin inhibits the reaction [Curcumin results in increased expression of DDIT3 protein]
|
CTD |
PMID:17171638 |
|
NCBI chr 7:65,001,695...65,006,517
Ensembl chr 7:63,116,380...63,121,201
|
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G
|
Dkk1
|
dickkopf WNT signaling pathway inhibitor 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of DKK1 mRNA]
|
CTD |
PMID:28321046 |
|
NCBI chr 1:237,794,969...237,798,650
Ensembl chr 1:228,381,521...228,385,202
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G
|
Dnmt3a
|
DNA methyltransferase 3 alpha
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3A protein]
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CTD |
PMID:23626723 |
|
NCBI chr 6:32,507,316...32,621,678
Ensembl chr 6:26,822,609...26,896,687
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G
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Dnmt3b
|
DNA methyltransferase 3 beta
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3B protein]
|
CTD |
PMID:23626723 |
|
NCBI chr 3:162,590,777...162,629,313
Ensembl chr 3:142,130,592...142,169,124
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G
|
Dnmt3l
|
DNA methyltransferase 3 like
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[4-tert-octylphenol co-treated with 4-nonylphenol] results in decreased expression of DNMT3L protein]
|
CTD |
PMID:23626723 |
|
NCBI chr20:10,614,933...10,629,337
Ensembl chr20:10,614,934...10,629,516
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G
|
E2f1
|
E2F transcription factor 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Vanadates results in increased expression of E2F1 protein]
|
CTD |
PMID:14971663 |
|
NCBI chr 3:163,524,739...163,535,563
Ensembl chr 3:143,049,478...143,075,361
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G
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Edn1
|
endothelin 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]
|
CTD |
PMID:12839867 |
|
NCBI chr17:22,660,799...22,666,687
Ensembl chr17:22,454,420...22,460,885
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G
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Eef1a2
|
eukaryotic translation elongation factor 1 alpha 2
|
multiple interactions increases expression
|
ISO
|
[Wortmannin co-treated with 1-Methyl-4-phenylpyridinium] results in increased expression of EEF1A2 protein Wortmannin results in increased expression of EEF1A2 protein
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CTD |
PMID:37051183 |
|
NCBI chr 3:168,265,893...168,275,071
Ensembl chr 3:168,195,357...168,275,071
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G
|
Egf
|
epidermal growth factor
|
multiple interactions
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ISO EXP
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[2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNB1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CCNE1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK1 protein]; [2-(2-chloro-4-iodophenylamino)-N-cyclopropylmethoxy-3,4-difluoro-5-bromobenzamide co-treated with Wortmannin] inhibits the reaction [EGF protein results in increased expression of CDK2 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein] Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased uptake of Fructose]
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CTD |
PMID:15691865 PMID:15849355 PMID:25856345 PMID:26385184 |
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NCBI chr 2:220,893,660...220,976,331
Ensembl chr 2:218,219,415...218,302,064
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G
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Egfr
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epidermal growth factor receptor
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of EGFR protein]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of EGFR mRNA] wortmannin inhibits the reaction [Sodium Chloride results in increased phosphorylation of EGFR protein]
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CTD |
PMID:15177934 PMID:21568938 PMID:25856345 PMID:36190352 |
|
NCBI chr14:95,378,626...95,551,358
Ensembl chr14:91,177,067...91,344,382
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G
|
Eif4ebp1
|
eukaryotic translation initiation factor 4E binding protein 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of EIF4EBP1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form]
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CTD |
PMID:12569580 PMID:20936651 PMID:32802178 |
|
NCBI chr16:71,495,457...71,508,845
Ensembl chr16:64,790,226...64,805,984
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G
|
Elk1
|
ETS transcription factor ELK1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of ELK1 mRNA]
|
CTD |
PMID:36190352 PMID:37992829 |
|
NCBI chr X:3,692,367...3,709,252
Ensembl chr X:1,139,756...1,155,713
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G
|
Epor
|
erythropoietin receptor
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [testosterone-3-carboxymethyloxime-bovine serum albumin conjugate results in increased expression of EPOR mRNA]
|
CTD |
PMID:20189893 |
|
NCBI chr 8:28,765,738...28,770,371
Ensembl chr 8:20,489,678...20,494,257
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G
|
Esr1
|
estrogen receptor 1
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decreases reaction
|
EXP
|
wortmannin inhibits the reaction [estrogen increases expression of Esr1 mRNA] in rat uterus
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RGD |
PMID:17272396 |
RGD:152177689 |
NCBI chr 1:43,511,685...43,904,454
Ensembl chr 1:41,210,475...41,495,002
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G
|
F3
|
coagulation factor III, tissue factor
|
multiple interactions
|
ISO
|
wortmannin promotes the reaction [Histamine results in increased expression of F3]
|
CTD |
PMID:16009787 |
|
NCBI chr 2:212,511,675...212,523,375
Ensembl chr 2:209,826,959...209,838,668
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G
|
Fas
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Fas cell surface death receptor
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affects response to substance
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ISO
|
Wortmannin affects the susceptibility to FAS protein
|
CTD |
PMID:31445927 |
|
NCBI chr 1:241,212,155...241,245,774
Ensembl chr 1:231,798,960...231,832,591
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G
|
Faslg
|
Fas ligand
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [evodiamine results in increased expression of FASLG protein]
|
CTD |
PMID:20005289 |
|
NCBI chr13:76,680,885...76,706,042
Ensembl chr13:74,154,954...74,162,215
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G
|
Fgf1
|
fibroblast growth factor 1
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decreases activity multiple interactions
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ISO EXP
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wortmannin results in decreased activity of FGF1 protein wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]
|
CTD |
PMID:15121739 PMID:15695173 |
|
NCBI chr18:30,937,670...31,023,786
Ensembl chr18:30,686,581...30,772,357
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G
|
Fgf7
|
fibroblast growth factor 7
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA]
|
CTD |
PMID:15803460 |
|
NCBI chr 3:133,734,557...133,786,678
Ensembl chr 3:113,281,283...113,332,929
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G
|
Fkbp1a
|
FKBP prolyl isomerase 1A
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FKBP1A mRNA]
|
CTD |
PMID:36190352 PMID:37992829 |
|
NCBI chr 3:160,500,748...160,520,492
Ensembl chr 3:140,040,278...140,060,743
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G
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Flna
|
filamin A
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [arsenic trichloride results in increased phosphorylation of FLNA protein]
|
CTD |
PMID:25944616 |
|
NCBI chr X:157,159,051...157,185,559
Ensembl chr X:152,007,758...152,031,052
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G
|
Flt3lg
|
Fms related receptor tyrosine kinase 3 ligand
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]
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CTD |
PMID:23001822 |
|
NCBI chr 1:104,751,518...104,756,925
Ensembl chr 1:95,609,370...95,620,463
|
|
G
|
Fos
|
Fos proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions
|
EXP ISO
|
wortmannin inhibits the reaction [15-deoxy-delta(12,14)-prostaglandin J2 results in increased expression of FOS mRNA] Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA] Wortmannin inhibits the reaction [Dieldrin results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOS protein]
|
CTD |
PMID:11687581 PMID:31068361 PMID:33582643 PMID:36190352 PMID:37992829 |
|
NCBI chr 6:110,852,188...110,855,054
Ensembl chr 6:105,121,170...105,124,036
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|
G
|
Foxo1
|
forkhead box O1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; wortmannin inhibits the reaction [Zinc affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate affects the localization of FOXO1 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO1 protein] Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FOXO1 mRNA]
|
CTD |
PMID:16973122 PMID:17935137 PMID:20936651 PMID:24024143 PMID:37992829 |
|
NCBI chr 2:138,462,974...138,541,420
Ensembl chr 2:136,312,168...136,387,790
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G
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Foxo3
|
forkhead box O3
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multiple interactions decreases phosphorylation
|
ISO
|
Wortmannin inhibits the reaction [arsenite results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in decreased activity of FOXO3 protein]; Wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of FOXO3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form] wortmannin results in decreased phosphorylation of FOXO3 protein
|
CTD |
PMID:17935137 PMID:20936651 PMID:23673518 PMID:24024143 PMID:25856345 |
|
NCBI chr20:47,251,968...47,348,254
Ensembl chr20:45,672,995...45,764,561
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|
G
|
Foxo4
|
forkhead box O4
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Copper results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Copper Sulfate results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc results in increased phosphorylation of FOXO4 protein]; wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of FOXO4 protein]
|
CTD |
PMID:16973122 |
|
NCBI chr X:70,425,218...70,432,120
Ensembl chr X:66,385,558...66,392,115
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|
G
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Foxp1
|
forkhead box P1
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decreases expression
|
ISO
|
wortmannin results in decreased expression of FOXP1 protein
|
CTD |
PMID:25663935 |
|
NCBI chr 4:133,117,346...133,808,647
Ensembl chr 4:131,564,756...132,112,258
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G
|
Fshb
|
follicle stimulating hormone subunit beta
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]]; wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of CYP11A1 mRNA]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
|
CTD |
PMID:25253736 |
|
NCBI chr 3:114,003,262...114,007,072
Ensembl chr 3:93,548,560...93,552,370
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|
G
|
Fshr
|
follicle stimulating hormone receptor
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of FSHR mRNA]
|
CTD |
PMID:37992829 |
|
NCBI chr 6:5,198,825...5,406,785
Ensembl chr 6:5,198,825...5,406,785
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|
G
|
Fth1
|
ferritin heavy chain 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [2-tert-butylhydroquinone results in increased expression of FTH1 mRNA]
|
CTD |
PMID:23829535 |
|
NCBI chr 1:216,052,037...216,054,325
Ensembl chr 1:206,627,103...206,725,424
|
|
G
|
G6pc1
|
glucose-6-phosphatase catalytic subunit 1
|
increases expression multiple interactions
|
ISO
|
Wortmannin results in increased expression of G6PC1 mRNA Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]
|
CTD |
PMID:24535192 |
|
NCBI chr10:86,807,659...86,819,023
Ensembl chr10:86,257,668...86,333,804
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|
G
|
Gast
|
gastrin
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decreases secretion
|
EXP
|
wortmannin results in decreased secretion of GAST protein
|
CTD |
PMID:19208342 |
|
NCBI chr10:85,765,216...85,767,881
Ensembl chr10:85,264,832...85,267,496
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|
G
|
Gclm
|
glutamate cysteine ligase, modifier subunit
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of GCLM mRNA]]
|
CTD |
PMID:34077701 |
|
NCBI chr 2:213,032,135...213,052,192
Ensembl chr 2:210,347,482...210,367,535
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|
G
|
Gdf15
|
growth differentiation factor 15
|
increases expression
|
ISO
|
wortmannin results in increased expression of GDF15 protein
|
CTD |
PMID:23178381 |
|
NCBI chr16:18,838,436...18,842,022
Ensembl chr16:18,805,239...18,808,055
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|
G
|
Gja1
|
gap junction protein, alpha 1
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [hydroxyflutamide results in decreased expression of GJA1 protein]
|
CTD |
PMID:26437446 |
|
NCBI chr20:36,302,490...36,315,010
Ensembl chr20:35,755,991...35,768,582
|
|
G
|
Glp1r
|
glucagon-like peptide 1 receptor
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Oleic Acid results in increased degradation of and results in decreased expression of GLP1R protein]
|
CTD |
PMID:22925809 |
|
NCBI chr20:8,972,004...9,010,241
Ensembl chr20:8,972,004...9,010,241
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G
|
Gnrh1
|
gonadotropin releasing hormone 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of GNRH1 mRNA]
|
CTD |
PMID:37992829 |
|
NCBI chr15:41,972,482...41,976,690
Ensembl chr15:41,972,905...41,973,581 Ensembl chr15:41,972,905...41,973,581
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|
G
|
Gper1
|
G protein-coupled estrogen receptor 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of GPER1 mRNA]
|
CTD |
PMID:36190352 |
|
NCBI chr12:20,331,073...20,336,527
Ensembl chr12:15,217,442...15,221,889
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G
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Grk2
|
G protein-coupled receptor kinase 2
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]]
|
CTD |
PMID:28759639 |
|
NCBI chr 1:211,010,259...211,031,013
Ensembl chr 1:201,581,480...201,601,582
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G
|
Grn
|
granulin precursor
|
multiple interactions
|
EXP
|
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; U 0126 promotes the reaction [wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]]; wortmannin inhibits the reaction [GRN protein results in decreased susceptibility to 1-methyl-4-phenyl-2,3-dihydropyridinium]; wortmannin inhibits the reaction [GRN protein results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:21820214 |
|
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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G
|
Gsk3a
|
glycogen synthase kinase 3 alpha
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [sphingosine 1-phosphate inhibits the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3A protein]]
|
CTD |
PMID:25769802 |
|
NCBI chr 1:89,943,669...89,953,514
Ensembl chr 1:80,815,850...80,825,802
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G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
multiple interactions decreases phosphorylation decreases expression
|
ISO EXP
|
Wortmannin affects the reaction [sphingosine 1-phosphate affects the reaction [beta-N-methylamino-L-alanine results in increased expression of GSK3B protein]]; Wortmannin inhibits the reaction [Bortezomib results in decreased activity of and results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Estradiol results in increased phosphorylation of GSK3B protein]; Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in decreased phosphorylation of GSK3B protein]]; Wortmannin inhibits the reaction [sodium arsenite results in increased phosphorylation of and results in increased activity of GSK3B protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of GSK3B protein] wortmannin results in decreased phosphorylation of GSK3B protein wortmannin inhibits the reaction [chaetoglobosins results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [GRK2 protein results in increased phosphorylation of GSK3B protein]; wortmannin inhibits the reaction [rosiglitazone results in increased phosphorylation of GSK3B protein] wortmannin results in decreased expression of GSK3B protein modified form Melatonin inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; Vitamin E inhibits the reaction [wortmannin results in decreased expression of GSK3B protein modified form]; wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of GSK3B protein modified form]]
|
CTD |
PMID:12614848 PMID:15842767 PMID:16076840 PMID:17513037 PMID:18040759 PMID:19566839 PMID:20090934 PMID:23170834 PMID:23178381 PMID:24085292 PMID:25769802 PMID:28759639 PMID:31173752 More...
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|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:62,504,316...62,648,646
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G
|
H2ax
|
H2A.X variant histone
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of H2AX protein]; Wortmannin inhibits the reaction [Decitabine results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Docetaxel results in increased expression of H2AX protein]; Wortmannin promotes the reaction [Soil Pollutants results in increased phosphorylation of H2AX protein]
|
CTD |
PMID:17991895 PMID:20878124 PMID:22409540 PMID:34784199 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:44,671,786...44,673,239 Ensembl chr 4:44,671,786...44,673,239
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|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions decreases reaction decreases expression
|
ISO EXP
|
[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [cobaltous chloride results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [CR 3294 results in decreased expression of HIF1A protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A mRNA]; wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of HIF1A protein] wortmannin inhibits the reaction [estrogen increases expression of Hif1a mRNA] in rat uterus wortmannin results in decreased expression of HIF1A protein
|
CTD RGD |
PMID:11424089 PMID:13679210 PMID:14726529 PMID:15050414 PMID:16499871 PMID:18927491 PMID:19640849 PMID:20153296 PMID:20335389 PMID:23968725 PMID:17272396 More...
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RGD:152177689 |
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:92,624,390...92,669,261
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|
G
|
Hmgb1
|
high mobility group box 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased secretion of and affects the localization of HMGB1 protein]
|
CTD |
PMID:19265175 |
|
NCBI chr12:11,009,236...11,015,941
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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|
G
|
Hmox1
|
heme oxygenase 1
|
multiple interactions
|
ISO EXP
|
Wortmannin inhibits the reaction [10-nitro-oleic acid results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Acrolein results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide results in increased expression of HMOX1 mRNA]]; Wortmannin inhibits the reaction [plumbagin results in increased expression of HMOX1 protein] Wortmannin inhibits the reaction [astringin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [naringenin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Quercetin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Resveratrol results in increased expression of HMOX1 protein] Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [4-hydroxy-2-nonenal results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [bisdemethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [Curcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [demethoxycurcumin results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [hydroquinone results in increased expression of HMOX1 mRNA]; Wortmannin inhibits the reaction [hydroquinone results in increased expression of HMOX1 protein]; Wortmannin inhibits the reaction [quinone results in increased expression of HMOX1 protein]
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CTD |
PMID:17535857 PMID:18048804 PMID:20028456 PMID:20117814 PMID:22022464 PMID:22056766 PMID:22709785 PMID:23290930 PMID:23845594 PMID:24423726 PMID:34077701 More...
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NCBI chr19:13,452,365...13,479,823
Ensembl chr19:13,467,244...13,474,079
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G
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Hsf1
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heat shock transcription factor 1
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affects localization multiple interactions
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ISO
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wortmannin affects the localization of HSF1 protein wortmannin inhibits the reaction [Oxygen deficiency results in increased expression of HSF1 mRNA]
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CTD |
PMID:11424089 PMID:20090934 |
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NCBI chr 7:110,076,710...110,103,665
Ensembl chr 7:108,196,056...108,223,011
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G
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Hspa1a
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heat shock protein family A (Hsp70) member 1A
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decreases expression
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ISO
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wortmannin results in decreased expression of HSPA1A protein; wortmannin results in decreased expression of HSPA1A protein alternative form
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CTD |
PMID:20090934 |
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NCBI chr20:3,875,411...3,877,866
Ensembl chr20:3,856,006...3,873,227
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G
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Hspa5
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heat shock protein family A (Hsp70) member 5
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Thapsigargin results in increased expression of HSPA5 mRNA]
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CTD |
PMID:19428936 |
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NCBI chr 3:38,453,016...38,457,475
Ensembl chr 3:18,055,405...18,059,891
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G
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Icam1
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intercellular adhesion molecule 1
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multiple interactions
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EXP ISO
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wortmannin inhibits the reaction [resveratrol results in decreased activity of ICAM1 protein] wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]
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CTD |
PMID:20117814 PMID:23114885 |
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NCBI chr 8:27,829,688...27,841,618
Ensembl chr 8:19,553,645...19,565,438
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G
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Ifnb1
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interferon beta 1
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multiple interactions
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ISO
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wortmannin inhibits the reaction [[Vehicle Emissions analog co-treated with Poly I-C] results in increased expression of IFNB1 mRNA]
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CTD |
PMID:16399790 |
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NCBI chr 5:108,066,650...108,067,487
Ensembl chr 5:103,020,969...103,021,523
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G
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Ifng
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interferon gamma
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
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CTD |
PMID:16968468 PMID:25352548 |
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NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:53,903,337...53,907,375
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G
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Igf1
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insulin-like growth factor 1
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multiple interactions
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ISO EXP
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[wortmannin co-treated with U 0126] inhibits the reaction [IGF1 protein promotes the reaction [cobaltous chloride results in increased expression of HIF1A protein]]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]; wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased phosphorylation of EIF4EBP1 protein]; wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein] Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IGF1 protein]] wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]
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CTD |
PMID:12569580 PMID:14745455 PMID:16499871 PMID:16682453 PMID:17520698 PMID:19657059 PMID:20733350 PMID:32805344 More...
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NCBI chr 7:24,169,608...24,249,446
Ensembl chr 7:22,282,930...22,359,296
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G
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Igf2
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insulin-like growth factor 2
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decreases response to substance multiple interactions
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ISO
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wortmannin results in decreased susceptibility to IGF2 protein wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]
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CTD |
PMID:24055520 |
|
NCBI chr 1:207,243,873...207,261,263
Ensembl chr 1:197,814,410...197,823,018
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G
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Il12a
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interleukin 12A
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multiple interactions
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ISO
|
Wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; Wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12A mRNA]; Wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]
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CTD |
PMID:16116186 |
|
NCBI chr 2:155,275,734...155,282,997
Ensembl chr 2:152,965,769...152,972,734
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G
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Il12b
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interleukin 12B
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multiple interactions
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ISO
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wortmannin inhibits the reaction [C5 protein results in decreased expression of [IL12A protein binds to IL12B protein]]; wortmannin inhibits the reaction [C5 protein results in decreased expression of IL12B mRNA]; wortmannin inhibits the reaction [N(6)-(3-iodobenzyl)-5'-N-methylcarboxamidoadenosine results in decreased expression of [IL12A protein binds to IL12B protein]]
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CTD |
PMID:16116186 |
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NCBI chr10:29,390,300...29,405,194
Ensembl chr10:28,893,008...28,902,903
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G
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Il17a
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interleukin 17A
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multiple interactions
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ISO
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wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of IL17A mRNA]
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CTD |
PMID:17982072 |
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NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:23,144,402...23,147,889
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G
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Il18
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interleukin 18
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multiple interactions
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ISO
|
wortmannin inhibits the reaction [Isoproterenol results in increased secretion of IL18 protein]
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CTD |
PMID:15178407 |
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NCBI chr 8:59,802,072...59,829,275
Ensembl chr 8:50,906,960...50,932,887
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G
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Il1a
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interleukin 1 alpha
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multiple interactions
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ISO
|
wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]
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CTD |
PMID:16968468 |
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NCBI chr 3:136,979,804...136,990,236
Ensembl chr 3:116,526,604...116,536,822
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G
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Il1b
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interleukin 1 beta
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multiple interactions increases expression
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ISO EXP
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wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]; wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] [wortmannin cotreatment with isoflurane] increases expression of IL1b protein in hippocampus Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]]
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CTD RGD |
PMID:16359550 PMID:22952890 PMID:25352548 PMID:30221701 |
RGD:597931096 |
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:116,577,010...116,583,415
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G
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Il1rn
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interleukin 1 receptor antagonist
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decreases expression
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ISO
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wortmannin results in decreased expression of IL1RN mRNA
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CTD |
PMID:26847702 |
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NCBI chr 3:27,509,836...27,525,738
Ensembl chr 3:7,111,550...7,127,445
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G
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Il23a
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interleukin 23 subunit alpha
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multiple interactions
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ISO
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wortmannin inhibits the reaction [C5 protein results in decreased expression of IL23A mRNA]
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CTD |
PMID:16116186 |
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NCBI chr 7:1,306,320...1,308,434
Ensembl chr 7:721,809...723,923
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G
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Il3
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interleukin 3
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multiple interactions
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ISO
|
Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [IL3 protein results in decreased expression of CCR3 protein]
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CTD |
PMID:11544337 PMID:23001822 |
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NCBI chr10:38,906,460...38,908,810
Ensembl chr10:38,405,716...38,408,066
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G
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Il4
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interleukin 4
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multiple interactions
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EXP
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Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of and results in increased secretion of IL4 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased expression of IL4 mRNA]
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CTD |
PMID:10611455 |
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NCBI chr10:38,272,003...38,277,549
Ensembl chr10:37,771,203...37,776,750
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G
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Il6
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interleukin 6
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multiple interactions increases expression
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EXP ISO
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wortmannin inhibits the reaction [resveratrol results in decreased activity of IL6 protein] [wortmannin cotreatment with isoflurane] increases expression of IL6 protein in hippocampus [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA] wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 mRNA]; wortmannin inhibits the reaction [di-n-butyltin results in increased expression of IL6 protein]
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CTD RGD |
PMID:20117814 PMID:24631921 PMID:30217479 PMID:30221701 |
RGD:597931096 |
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,213,394...5,219,178
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G
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Ins1
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insulin 1
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multiple interactions
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ISO EXP
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Wortmannin inhibits the reaction [BLX 1002 promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased activity of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1S1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased transport of Sodium]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of Glucose]; Wortmannin inhibits the reaction [mono-(2-ethylhexyl)phthalate promotes the reaction [INS1 protein results in increased uptake of Glucose]]; Wortmannin inhibits the reaction [Raffinose promotes the reaction [INS1 protein results in increased uptake of Deoxyglucose]] Wortmannin inhibits the reaction [apigenin-6-C-(2''-O-rhamnopyranosyl)-fucopyranoside promotes the reaction [Glucose results in increased secretion of INS1 protein]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of AHR mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of ARNT mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]]; Wortmannin inhibits the reaction [INS1 protein inhibits the reaction [Epinephrine results in increased transport of Fatty Acids, Nonesterified]]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of AHR mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of ARNT mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1A2 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP1B1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in decreased expression of CYP2E1 mRNA]; Wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [INS1 protein results in increased uptake of 2-(methylamino)isobutyric acid]
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CTD |
PMID:9877156 PMID:11306697 PMID:15172182 PMID:17962351 PMID:18591783 PMID:19052259 PMID:19070612 PMID:20880397 PMID:25543134 PMID:25805502 PMID:26466350 PMID:29458019 More...
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NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:251,244,973...251,245,536
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G
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Ins2
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insulin 2
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multiple interactions
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ISO EXP
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[Wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; Wortmannin inhibits the reaction [INS protein results in decreased expression of G6PC1 mRNA]; Wortmannin inhibits the reaction [INS protein results in decreased susceptibility to Coumaric Acids]; Wortmannin inhibits the reaction [INS protein results in increased expression of EIF4EBP1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of FOXO3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form]; Wortmannin inhibits the reaction [INS protein results in increased phosphorylation of AKT1 protein] wortmannin inhibits the reaction [INS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]
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CTD |
PMID:11574405 PMID:17550345 PMID:17728140 PMID:20015842 PMID:20936651 PMID:24535192 PMID:24748653 More...
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NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:197,843,281...197,864,775
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G
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Insr
|
insulin receptor
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multiple interactions
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EXP
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Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of INSR mRNA]]
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CTD |
PMID:32805344 |
|
NCBI chr12:5,991,135...6,129,275
Ensembl chr12:1,197,100...1,330,883
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G
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Irak3
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interleukin-1 receptor-associated kinase 3
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decreases expression
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ISO
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wortmannin results in decreased expression of IRAK3 mRNA
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CTD |
PMID:26847702 |
|
NCBI chr 7:55,653,949...55,714,371
Ensembl chr 7:55,653,962...55,713,121
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G
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Irs1
|
insulin receptor substrate 1
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multiple interactions
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ISO EXP
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wortmannin inhibits the reaction [INS protein results in increased expression of IRS1 protein modified form] Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of IRS1 mRNA]]
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CTD |
PMID:20936651 PMID:32805344 |
|
NCBI chr 9:91,001,137...91,053,959
Ensembl chr 9:83,548,944...83,606,122
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G
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Itgav
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integrin subunit alpha V
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multiple interactions
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ISO
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wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
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CTD |
PMID:15213856 |
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NCBI chr 3:89,245,382...89,333,512
Ensembl chr 3:68,838,189...68,926,639
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G
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Itgb2
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integrin subunit beta 2
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multiple interactions
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ISO
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wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]
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CTD |
PMID:16963453 |
|
NCBI chr20:11,061,009...11,097,242
Ensembl chr20:11,061,430...11,097,600
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G
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Itgb3
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integrin subunit beta 3
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multiple interactions
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ISO
|
wortmannin inhibits the reaction [manganese chloride affects the localization of and affects the activity of [ITGB3 protein binds to ITGAV protein]]
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CTD |
PMID:15213856 |
|
NCBI chr10:90,009,927...90,067,787
Ensembl chr10:89,509,989...89,564,679
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G
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Kcnh1
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potassium voltage-gated channel subfamily H member 1
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multiple interactions
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ISO
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wortmannin inhibits the reaction [IGF1 protein results in increased activity of KCNH1 protein]
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CTD |
PMID:17520698 |
|
NCBI chr13:103,722,140...104,024,762
Ensembl chr13:103,722,245...104,024,740
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G
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Kitlg
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KIT ligand
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multiple interactions
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ISO
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wortmannin inhibits the reaction [KITL protein results in increased expression of CCND3 protein]; wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein] wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of AKT1 protein]; wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]
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CTD |
PMID:10849422 PMID:23001822 |
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NCBI chr 7:34,896,075...34,977,215
Ensembl chr 7:34,896,053...34,977,214
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G
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Klf4
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KLF transcription factor 4
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multiple interactions
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EXP
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wortmannin inhibits the reaction [Estradiol results in increased expression of KLF4 protein]
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CTD |
PMID:21484412 |
|
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G
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Klf6
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KLF transcription factor 6
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decreases expression multiple interactions
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ISO
|
Wortmannin results in decreased expression of KLF6 mRNA Wortmannin inhibits the reaction [Arachidonic Acid promotes the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]]; Wortmannin inhibits the reaction [CYP2E1 protein results in increased expression of KLF6 mRNA]
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CTD |
PMID:22486562 |
|
NCBI chr17:64,539,456...64,548,451
Ensembl chr17:64,531,463...64,588,570
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G
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Kng1
|
kininogen 1
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multiple interactions
|
EXP
|
KNG1 protein inhibits the reaction [[Wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; Wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein]
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CTD |
PMID:10537051 |
|
NCBI chr11:91,317,354...91,340,148
Ensembl chr11:77,812,752...77,835,555
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G
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Lat2
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linker for activation of T cells family, member 2
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased expression of LAT2 protein]
|
CTD |
PMID:23001822 |
|
NCBI chr12:22,104,173...22,118,294
Ensembl chr12:22,104,219...22,118,288
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G
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Lep
|
leptin
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decreases expression multiple interactions decreases secretion
|
ISO
|
wortmannin results in decreased expression of LEP mRNA wortmannin inhibits the reaction [LEP protein results in increased transport of Calcium] wortmannin results in decreased secretion of LEP protein
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CTD |
PMID:19254925 PMID:20107083 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:57,661,131...57,675,262
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G
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Lhcgr
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luteinizing hormone/choriogonadotropin receptor
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multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of LHR mRNA]
|
CTD |
PMID:37992829 |
|
NCBI chr 6:11,415,361...11,480,834
Ensembl chr 6:5,661,871...5,724,521
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G
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Lig1
|
DNA ligase 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of LIG1 protein]
|
CTD |
PMID:16700562 |
|
NCBI chr 1:74,165,688...74,204,400
Ensembl chr 1:74,165,842...74,204,413
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G
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Map1lc3b
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microtubule-associated protein 1 light chain 3 beta
|
multiple interactions decreases expression
|
ISO
|
wortmannin inhibits the reaction [Rotenone results in increased expression of MAP1LC3B protein] wortmannin results in decreased expression of MAP1LC3B protein
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CTD |
PMID:26847702 |
|
NCBI chr19:66,571,631...66,582,270
Ensembl chr19:49,665,791...49,677,690 Ensembl chr16:49,665,791...49,677,690
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G
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Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions decreases phosphorylation increases phosphorylation
|
ISO EXP
|
[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [bisphenol AF results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK1 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK1 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK1 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK1 protein] Wortmannin inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK1 protein] wortmannin results in decreased phosphorylation of MAPK1 protein wortmannin results in increased phosphorylation of MAPK1 protein Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK1 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK1 protein]]
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CTD |
PMID:10611455 PMID:15086530 PMID:15177934 PMID:15287886 PMID:15355987 PMID:15608143 PMID:16499871 PMID:18950629 PMID:19139269 PMID:19477951 PMID:20522546 PMID:20936651 PMID:22952890 PMID:24568969 PMID:25002221 PMID:25856345 PMID:27880919 PMID:30590302 PMID:33582643 PMID:36190352 More...
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NCBI chr11:97,462,025...97,529,193
Ensembl chr11:83,957,813...84,023,616
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G
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Mapk14
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mitogen activated protein kinase 14
|
multiple interactions
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ISO
|
wortmannin promotes the reaction [Tretinoin results in increased phosphorylation of MAPK14 protein]
|
CTD |
PMID:12032135 |
|
NCBI chr20:6,751,288...6,812,294
Ensembl chr20:6,749,670...6,810,589
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G
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Mapk3
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mitogen activated protein kinase 3
|
multiple interactions decreases phosphorylation increases phosphorylation
|
ISO EXP
|
[bisindolylmaleimide I co-treated with Wortmannin] inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; KN 93 promotes the reaction [Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin inhibits the reaction [anandamide results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [bis(4-oxyphenyl)sulfide results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [bisphenol AF results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [CXCL2 protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of MAPK3 protein modified form]; Wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]; Wortmannin inhibits the reaction [ON123300 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK3 mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]; Wortmannin promotes the reaction [KN 93 inhibits the reaction [Zinc Sulfate results in increased phosphorylation of MAPK3 protein]]; Wortmannin promotes the reaction [ochratoxin A results in increased phosphorylation of MAPK3 protein] Wortmannin inhibits the reaction [[alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid co-treated with aniracetam] results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased activity of MAPK3 protein] wortmannin results in decreased phosphorylation of MAPK3 protein wortmannin results in increased phosphorylation of MAPK3 protein Wortmannin affects the reaction [Ptychodiscus brevis T2 toxin affects the phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK3 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of MAPK3 protein]]
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CTD |
PMID:10611455 PMID:15086530 PMID:15177934 PMID:15287886 PMID:15355987 PMID:15608143 PMID:16499871 PMID:18950629 PMID:19139269 PMID:19477951 PMID:20522546 PMID:20936651 PMID:22952890 PMID:24568969 PMID:25002221 PMID:25856345 PMID:27880919 PMID:30590302 PMID:33582643 PMID:36190352 More...
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NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:181,366,637...181,372,863
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G
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Mapk6
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mitogen-activated protein kinase 6
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multiple interactions
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ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK6 mRNA]
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CTD |
PMID:36190352 |
|
NCBI chr 8:76,146,650...76,169,767
Ensembl chr 8:76,146,690...76,169,720
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G
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Mapk8
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mitogen-activated protein kinase 8
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multiple interactions decreases phosphorylation
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ISO EXP
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wortmannin inhibits the reaction [3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol results in increased phosphorylation of MAPK8 protein]; wortmannin inhibits the reaction [HU 211 results in increased phosphorylation of MAPK8 protein] Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MAPK8 mRNA] Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK8 protein] wortmannin results in decreased phosphorylation of MAPK8 protein
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CTD |
PMID:10611455 PMID:18950629 PMID:36190352 |
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NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,638,924...8,721,981
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G
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Mapk9
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mitogen-activated protein kinase 9
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multiple interactions
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EXP
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Wortmannin inhibits the reaction [dinitrophenyl-human serum albumin conjugate results in increased phosphorylation of MAPK9 protein]
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CTD |
PMID:10611455 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,169,675...34,210,178
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G
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Mapt
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microtubule-associated protein tau
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multiple interactions increases phosphorylation
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ISO
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Melatonin inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein]; Vitamin E inhibits the reaction [wortmannin results in increased phosphorylation of MAPT protein] Wortmannin inhibits the reaction [Liraglutide inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPT protein]]
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CTD |
PMID:15842767 PMID:31173752 |
|
NCBI chr10:89,638,618...89,736,108
Ensembl chr10:89,138,627...89,236,129
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G
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Mcl1
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MCL1 apoptosis regulator, BCL2 family member
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multiple interactions decreases expression
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ISO
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AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of CASP3 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of MCL1 protein]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased stability of and results in decreased ubiquitination of MCL1 protein]; Wortmannin inhibits the reaction [Leukotriene B4 results in increased expression of MCL1 protein]; Wortmannin promotes the reaction [Doxorubicin results in decreased expression of MCL1 protein]; Wortmannin promotes the reaction [Etoposide results in decreased expression of MCL1 protein] wortmannin results in decreased expression of MCL1 protein
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CTD |
PMID:15970427 PMID:17935137 PMID:23353698 PMID:32802178 |
|
NCBI chr 2:185,884,840...185,912,532
Ensembl chr 2:183,219,220...183,222,303
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G
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Mdm2
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MDM2 proto-oncogene
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multiple interactions
|
ISO
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wortmannin promotes the reaction [Doxorubicin results in increased phosphorylation of MDM2 protein]; wortmannin promotes the reaction [Etoposide results in increased phosphorylation of MDM2 protein]
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CTD |
PMID:17935137 |
|
NCBI chr 7:55,176,558...55,201,757
Ensembl chr 7:53,290,664...53,314,915
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G
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Mir200a
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microRNA 200a
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multiple interactions
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ISO
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[wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR200A mRNA
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CTD |
PMID:25969534 |
|
NCBI chr 5:166,648,494...166,648,582
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G
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Mir21
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microRNA 21
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Dehydroepiandrosterone results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [fludioxonil results in increased expression of MIR21 mRNA]; wortmannin inhibits the reaction [N-(2,3-dichloro-4-hydroxyphenyl)-1-methylcyclohexanecarboxamide results in increased expression of MIR21 mRNA]
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CTD |
PMID:23052036 PMID:25969534 |
|
NCBI chr10:71,902,600...71,902,691
Ensembl chr10:71,405,257...71,405,348
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G
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Mir22
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microRNA 22
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multiple interactions
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ISO
|
[wortmannin co-treated with Dehydroepiandrosterone] results in increased expression of MIR22 mRNA
|
CTD |
PMID:25969534 |
|
NCBI chr10:60,805,331...60,805,425
Ensembl chr10:60,307,039...60,307,133
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G
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Mmp12
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matrix metallopeptidase 12
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multiple interactions
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ISO
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wortmannin inhibits the reaction [IL1B protein results in increased activity of MMP12 protein]; wortmannin inhibits the reaction [IL1B protein results in increased expression of MMP12 mRNA]
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CTD |
PMID:16359550 |
|
NCBI chr 8:12,866,652...12,876,554
Ensembl chr 8:4,581,785...4,599,611
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G
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Mmp14
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matrix metallopeptidase 14
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multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of MMP14 protein]
|
CTD |
PMID:36288207 |
|
NCBI chr15:31,857,824...31,867,049
Ensembl chr15:27,887,727...27,899,864
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G
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Mmp2
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matrix metallopeptidase 2
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multiple interactions decreases expression
|
ISO
|
brazilein promotes the reaction [wortmannin results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin promotes the reaction [brazilein results in decreased expression of and results in decreased activity of MMP2 protein]; wortmannin results in decreased expression of and results in decreased activity of MMP2 protein wortmannin results in decreased expression of MMP2
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CTD |
PMID:23707804 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:14,154,657...14,182,870
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|
G
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Mmp9
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matrix metallopeptidase 9
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multiple interactions decreases activity
|
EXP ISO
|
wortmannin inhibits the reaction [Adenosine Triphosphate results in increased activity of MMP9 protein] wortmannin results in decreased activity of MMP9 protein wortmannin inhibits the reaction [fucoidan results in decreased expression of MMP9]; wortmannin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wortmannin promotes the reaction [ovatodiolide results in decreased activity of MMP9 protein]
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CTD |
PMID:20195827 PMID:22033475 PMID:23288142 PMID:24333868 |
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NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:153,683,858...153,692,120
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|
G
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Mpo
|
myeloperoxidase
|
multiple interactions
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ISO EXP
|
Wortmannin inhibits the reaction [[[MPO protein co-treated with Chlorides co-treated with Threonine co-treated with Hydrogen Peroxide] results in increased chemical synthesis of Acrolein] which results in increased phosphorylation of AKT1 protein]; Wortmannin inhibits the reaction [N-Formylmethionine Leucyl-Phenylalanine results in increased secretion of MPO protein] wortmannin inhibits the reaction [resveratrol results in decreased activity of MPO protein]
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CTD |
PMID:18987595 PMID:20117814 PMID:26262998 |
|
NCBI chr10:73,092,124...73,102,057
Ensembl chr10:72,594,661...72,604,819
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G
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Ms4a2
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membrane spanning 4-domains A2
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multiple interactions decreases response to substance
|
ISO
|
MS4A2 protein mutant form inhibits the reaction [wortmannin inhibits the reaction [Antigens results in increased abundance of Hydrogen Peroxide]] MS4A2 protein mutant form results in decreased susceptibility to wortmannin
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CTD |
PMID:19467708 |
|
NCBI chr 1:217,864,855...217,873,934
Ensembl chr 1:208,440,361...208,448,310
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G
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Mt1
|
metallothionein 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [Cadmium Chloride results in increased expression of MT1 mRNA]; Wortmannin inhibits the reaction [zinc chloride results in increased expression of MT1 mRNA]
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CTD |
PMID:11551972 |
|
NCBI chr19:10,826,032...10,827,048
Ensembl chr19:10,826,032...10,827,049 Ensembl chr17:10,826,032...10,827,049 Ensembl chr X:10,826,032...10,827,049
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G
|
Mt3
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metallothionein 3
|
decreases response to substance
|
ISO
|
wortmannin results in decreased susceptibility to MT3 protein
|
CTD |
PMID:19767621 |
|
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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G
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Mtor
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mechanistic target of rapamycin kinase
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of MTOR protein]; Wortmannin inhibits the reaction [Capsaicin results in increased phosphorylation of MTOR protein] Wortmannin inhibits the reaction [cyanoginosin LR results in increased phosphorylation of MTOR protein]
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CTD |
PMID:19139269 PMID:32802178 PMID:36288207 |
|
NCBI chr 5:164,167,985...164,277,438
Ensembl chr 5:158,884,804...158,994,311
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|
G
|
Mtr
|
5-methyltetrahydrofolate-homocysteine methyltransferase
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [Dopamine results in increased activity of MTR protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased activity of MTR protein]
|
CTD |
PMID:14745455 |
|
NCBI chr17:58,219,998...58,308,560
Ensembl chr17:58,220,071...58,304,822
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|
G
|
Myc
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MYC proto-oncogene, bHLH transcription factor
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC mRNA]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC protein] Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of MYC protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of MYC mRNA]
|
CTD |
PMID:33582643 PMID:36190352 PMID:36288207 PMID:37992829 |
|
NCBI chr 7:95,483,105...95,488,031
Ensembl chr 7:93,593,705...93,598,630
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|
G
|
Mycn
|
MYCN proto-oncogene, bHLH transcription factor
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYCN protein]
|
CTD |
PMID:12569580 |
|
NCBI chr 6:41,446,683...41,452,584
Ensembl chr 6:35,717,764...35,723,590
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G
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Myh4
|
myosin heavy chain 4
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [IGF1 protein results in increased expression of MYH4 mRNA]
|
CTD |
PMID:19657059 |
|
NCBI chr10:51,923,149...51,946,297
Ensembl chr10:51,885,913...51,946,295
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|
G
|
Myl7
|
myosin light chain 7
|
multiple interactions decreases phosphorylation
|
ISO
|
wortmannin inhibits the reaction [Phenylephrine results in increased phosphorylation of MYL7 protein] wortmannin results in decreased phosphorylation of MYL7 protein
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CTD |
PMID:15621049 |
|
NCBI chr14:80,780,684...80,783,259
Ensembl chr14:80,779,776...80,783,244
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|
G
|
Ncoa4
|
nuclear receptor coactivator 4
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [Palmitic Acid results in increased expression of NCOA4 protein]
|
CTD |
PMID:32283200 |
|
NCBI chr16:7,389,222...7,409,564
Ensembl chr16:7,366,542...7,409,641 Ensembl chr16:7,366,542...7,409,641
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|
G
|
Ncs1
|
neuronal calcium sensor 1
|
multiple interactions
|
EXP
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wortmannin inhibits the reaction [NCS1 protein results in increased phosphorylation of phosphatidylinositol 4-phosphate]
|
CTD |
PMID:12471042 |
|
NCBI chr 3:34,920,949...34,966,554
Ensembl chr 3:14,523,220...14,568,829
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G
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Ndrg1
|
N-myc downstream regulated 1
|
decreases phosphorylation multiple interactions
|
ISO
|
wortmannin results in decreased phosphorylation of NDRG1 protein wortmannin inhibits the reaction [INS1 protein results in increased phosphorylation of NDRG1 protein]
|
CTD |
PMID:20880397 |
|
NCBI chr 7:100,573,526...100,614,902
Ensembl chr 7:98,684,487...98,725,880
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G
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Nedd4
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NEDD4 E3 ubiquitin protein ligase
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]
|
CTD |
PMID:20100827 |
|
NCBI chr 8:73,384,095...73,468,951
Ensembl chr 8:73,383,695...73,468,951
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|
G
|
Nfe2l2
|
NFE2 like bZIP transcription factor 2
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [formononetin promotes the reaction [Hydrogen Peroxide affects the localization of NFE2L2 protein]]
|
CTD |
PMID:34077701 |
|
NCBI chr 3:81,001,529...81,031,165
Ensembl chr 3:60,594,242...60,621,737
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G
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Nfkb1
|
nuclear factor kappa B subunit 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]
|
CTD |
PMID:18207479 |
|
NCBI chr 2:226,689,745...226,805,897
Ensembl chr 2:224,016,214...224,110,404
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G
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Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [Bortezomib results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Doxorubicin results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Etoposide results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [evodiamine results in increased phosphorylation of and results in increased degradation of NFKBIA protein]; Wortmannin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of NFKBIA protein] wortmannin inhibits the reaction [notoginsenoside R1 inhibits the reaction [Lipopolysaccharides results in decreased expression of NFKBIA protein]]
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CTD |
PMID:15142122 PMID:17935137 PMID:20005289 PMID:23170834 PMID:24085292 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:72,858,712...72,861,941
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G
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Ngf
|
nerve growth factor
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multiple interactions decreases activity
|
ISO EXP
|
wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein]; wortmannin inhibits the reaction [NGF results in increased susceptibility to Capsaicin] wortmannin results in decreased activity of NGF protein wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]; wortmannin inhibits the reaction [NGF protein results in increased phosphorylation of AKT1 protein]
|
CTD |
PMID:12815188 PMID:16319926 PMID:17324588 PMID:20629186 PMID:21975456 |
|
NCBI chr 2:192,589,580...192,642,971
Ensembl chr 2:189,901,058...189,954,452
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G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO EXP
|
Carvedilol promotes the reaction [Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]] Wortmannin inhibits the reaction [Mevinphos results in increased expression of NOS2 protein] wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA]
|
CTD |
PMID:12839867 PMID:17159805 PMID:22952890 PMID:24462917 PMID:25352548 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:63,815,308...63,851,210
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G
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Nos3
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nitric oxide synthase 3
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multiple interactions decreases phosphorylation
|
ISO EXP
|
Fenofibrate inhibits the reaction [wortmannin results in decreased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [arsenite results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [diallyl disulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [diallyl trisulfide results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [Nifedipine promotes the reaction [[Hydrogen Peroxide co-treated with Simvastatin] results in increased phosphorylation of and results in increased expression of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone promotes the reaction [Estradiol results in increased activity of NOS3 protein]]; wortmannin inhibits the reaction [Progesterone results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [Progesterone results in increased phosphorylation of NOS3 protein]; wortmannin inhibits the reaction [resveratrol results in increased phosphorylation of and results in increased activity of NOS3 protein]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [[Glucose results in decreased phosphorylation of NOS3 protein] which results in increased abundance of Nitric Oxide]]; wortmannin inhibits the reaction [rosiglitazone inhibits the reaction [Glucose results in decreased phosphorylation of NOS3 protein]]; wortmannin inhibits the reaction [Simvastatin promotes the reaction [[Hydrogen Peroxide co-treated with Nifedipine] results in increased phosphorylation of and results in increased expression of NOS3 protein]] wortmannin affects the reaction [Carbon Tetrachloride results in increased phosphorylation of and results in increased activity of NOS3 protein]
|
CTD |
PMID:11788791 PMID:15358673 PMID:16442496 PMID:18296501 PMID:18317400 PMID:18710710 PMID:19767878 PMID:20229525 PMID:20562903 More...
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|
NCBI chr 4:11,686,088...11,706,604
Ensembl chr 4:10,793,834...10,814,166
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G
|
Notch1
|
notch receptor 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Zinc affects the localization of NOTCH1 protein]; wortmannin inhibits the reaction [Zinc results in decreased activity of NOTCH1 protein]
|
CTD |
PMID:17513037 |
|
NCBI chr 3:29,676,040...29,721,613
Ensembl chr 3:9,278,086...9,323,531
|
|
G
|
Nqo1
|
NAD(P)H quinone dehydrogenase 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of NQO1 mRNA]; Wortmannin inhibits the reaction [plumbagin results in increased expression of NQO1 protein]
|
CTD |
PMID:20028456 PMID:34077701 |
|
NCBI chr19:52,205,374...52,220,267
Ensembl chr19:35,295,573...35,310,557
|
|
G
|
Nr5a1
|
nuclear receptor subfamily 5, group A, member 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Estradiol results in increased activity of NR5A1 protein]
|
CTD |
PMID:19549922 |
|
NCBI chr 3:42,874,505...42,896,109
Ensembl chr 3:22,465,502...22,486,328
|
|
G
|
Ntf3
|
neurotrophin 3
|
decreases transport
|
ISO
|
wortmannin results in decreased transport of NTF3 protein
|
CTD |
PMID:11948662 |
|
NCBI chr 4:160,601,161...160,670,623
Ensembl chr 4:158,914,957...158,984,596
|
|
G
|
Ntf4
|
neurotrophin 4
|
decreases transport
|
ISO
|
wortmannin results in decreased transport of NTF4 protein
|
CTD |
PMID:11948662 |
|
NCBI chr 1:105,030,035...105,032,866
Ensembl chr 1:95,893,457...95,897,243
|
|
G
|
Nts
|
neurotensin
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of AKT1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of EGFR protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK1 protein]; wortmannin inhibits the reaction [NTS protein results in increased phosphorylation of and results in increased activity of MAPK3 protein]
|
CTD |
PMID:15177934 |
|
NCBI chr 7:37,564,944...37,574,350
Ensembl chr 7:37,564,533...37,574,423
|
|
G
|
Pa2g4
|
proliferation-associated 2G4
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of PA2G4 mRNA]
|
CTD |
PMID:37992829 |
|
NCBI chr 7:984,795...992,264
Ensembl chr 7:983,971...992,331
|
|
G
|
Parp1
|
poly (ADP-ribose) polymerase 1
|
multiple interactions
|
ISO
|
AKT1 protein modified form inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; MCL1 protein inhibits the reaction [Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]]; Wortmannin inhibits the reaction [[[ABT-737 co-treated with Benzo(a)pyrene] co-treated with [sodium arsenite results in increased abundance of Arsenic]] results in decreased cleavage of PARP1 protein]; Wortmannin promotes the reaction [demethoxycurcumin results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Doxorubicin results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [Etoposide results in increased cleavage of PARP1 protein]; Wortmannin promotes the reaction [sodium arsenite results in increased degradation of PARP1 protein] wortmannin inhibits the reaction [Cyclosporine results in increased cleavage of PARP1 protein]
|
CTD |
PMID:12614848 PMID:17935137 PMID:22155090 PMID:32802178 PMID:34291863 |
|
NCBI chr13:94,839,484...94,871,295
Ensembl chr13:92,307,586...92,339,404
|
|
G
|
Pck1
|
phosphoenolpyruvate carboxykinase 1
|
multiple interactions
|
EXP
|
[troglitazone co-treated with wortmannin] results in decreased expression of PCK1 mRNA
|
CTD |
PMID:10446394 |
|
NCBI chr 3:182,348,572...182,354,521
Ensembl chr 3:161,930,256...161,936,191
|
|
G
|
Pdcd4
|
programmed cell death 4
|
increases expression
|
ISO
|
Wortmannin results in increased expression of PDCD4 mRNA; Wortmannin results in increased expression of PDCD4 protein
|
CTD |
PMID:17259349 |
|
NCBI chr 1:262,912,659...262,949,581
Ensembl chr 1:252,921,392...252,944,275
|
|
G
|
Pdk1
|
pyruvate dehydrogenase kinase 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of PDK1 protein]
|
CTD |
PMID:21655274 |
|
NCBI chr 3:77,113,464...77,144,145
Ensembl chr 3:56,705,871...56,733,038
|
|
G
|
Pdx1
|
pancreatic and duodenal homeobox 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein] [wortmannin co-treated with INS protein] inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose affects the localization of PDX1 protein]; wortmannin inhibits the reaction [Glucose results in increased phosphorylation of and results in increased activity of PDX1 protein]
|
CTD |
PMID:9873045 PMID:11574405 |
|
NCBI chr12:7,757,865...7,763,064
Ensembl chr12:7,757,865...7,763,064
|
|
G
|
Pdzk1
|
PDZ domain containing 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of PDZK1 mRNA]
|
CTD |
PMID:36190352 PMID:37992829 |
|
NCBI chr 2:184,376,161...184,407,514
Ensembl chr 2:184,376,161...184,407,514
|
|
G
|
Pgr
|
progesterone receptor
|
decreases reaction
|
EXP
|
wortmannin inhibits the reaction [estrogen increases expression of Pgr mRNA] in rat uterus
|
RGD |
PMID:17272396 |
RGD:152177689 |
NCBI chr 8:14,354,398...14,413,271
Ensembl chr 8:6,072,673...6,131,344
|
|
G
|
Pik3ca
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
|
multiple interactions decreases activity
|
ISO
|
wortmannin inhibits the reaction [Sirolimus results in increased activity of PIK3CA protein] Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of PIK3CA protein] wortmannin results in decreased activity of PIK3CA protein
|
CTD |
PMID:16227402 PMID:19036708 PMID:36288207 |
|
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:115,174,984...115,249,032
|
|
G
|
Pik3cb
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit beta
|
decreases activity decreases expression multiple interactions
|
ISO EXP
|
wortmannin results in decreased activity of PIK3CB protein [wortmannin cotreatment with isoflurane] decreases expression of PI3K mRNA,protein in hippocampus Wortmannin inhibits the reaction [cyanoginosin LR results in increased expression of PIK3CB protein]
|
CTD RGD |
PMID:11931710 PMID:36288207 PMID:30221701 |
RGD:597931096 |
NCBI chr 8:108,474,017...108,579,140
Ensembl chr 8:99,594,644...99,699,663
|
|
G
|
Pik3cd
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit delta
|
decreases activity
|
ISO
|
wortmannin results in decreased activity of PIK3CD protein
|
CTD |
PMID:21644799 |
|
NCBI chr 5:165,377,994...165,426,620
Ensembl chr 5:160,094,952...160,120,930
|
|
G
|
Pik3cg
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma
|
multiple interactions decreases activity
|
ISO EXP
|
wortmannin inhibits the reaction [Isoproterenol results in increased activity of PIK3CG protein] wortmannin promotes the reaction [GRK2 protein promotes the reaction [GRK2 protein binds to PIK3CG protein]] wortmannin results in decreased activity of PIK3CG protein
|
CTD |
PMID:15178407 PMID:21644799 PMID:28759639 |
|
NCBI chr 6:54,494,247...54,529,563
Ensembl chr 6:48,766,864...48,802,043
|
|
G
|
Pik3r1
|
phosphoinositide-3-kinase regulatory subunit 1
|
decreases activity multiple interactions
|
ISO EXP
|
wortmannin results in decreased activity of PIK3R1 protein Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PIK3R1 protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in decreased expression of PIK3R1 mRNA]]
|
CTD |
PMID:19036708 PMID:27832966 PMID:32805344 |
|
NCBI chr 2:34,612,946...34,697,660
Ensembl chr 2:32,882,032...32,963,631
|
|
G
|
Plac1
|
placenta enriched 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [FGF7 protein results in increased expression of PLAC1 mRNA]
|
CTD |
PMID:15803460 |
|
NCBI chr X:132,821,347...132,955,143
Ensembl chr X:132,821,347...132,985,668
|
|
G
|
Pln
|
phospholamban
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Progesterone inhibits the reaction [bisphenol A results in increased phosphorylation of PLN protein]]
|
CTD |
PMID:28324061 |
|
NCBI chr20:33,166,512...33,182,241
|
|
G
|
Postn
|
periostin
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [AGT protein results in increased expression of POSTN mRNA]; wortmannin inhibits the reaction [FGF1 protein results in increased expression of POSTN mRNA]
|
CTD |
PMID:15121739 |
|
NCBI chr 2:138,527,714...138,559,098
Ensembl chr 2:138,527,696...138,559,099
|
|
G
|
Ppara
|
peroxisome proliferator activated receptor alpha
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARA mRNA]
|
CTD |
PMID:23399309 |
|
NCBI chr 7:118,712,261...118,780,723
Ensembl chr 7:116,832,756...116,895,346
|
|
G
|
Ppard
|
peroxisome proliferator-activated receptor delta
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARD mRNA]
|
CTD |
PMID:23399309 |
|
NCBI chr20:6,300,527...6,365,707
Ensembl chr20:6,298,785...6,363,968
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [bisphenol A results in decreased expression of PPARG mRNA]
|
CTD |
PMID:23399309 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:148,423,194...148,548,468
|
|
G
|
Ppm1d
|
protein phosphatase, Mg2+/Mn2+ dependent, 1D
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Soil Pollutants results in increased expression of PPM1D protein]
|
CTD |
PMID:22409540 |
|
NCBI chr10:70,670,026...70,706,030
Ensembl chr10:70,172,603...70,208,607
|
|
G
|
Ppp1r1b
|
protein phosphatase 1, regulatory (inhibitor) subunit 1B
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [BDNF protein results in increased expression of PPP1R1B protein]
|
CTD |
PMID:17209049 |
|
NCBI chr10:83,843,948...83,853,063
Ensembl chr10:83,347,731...83,356,775
|
|
G
|
Prkcd
|
protein kinase C, delta
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Curcumin results in increased phosphorylation of PRKCD protein]; wortmannin inhibits the reaction [Oxygen deficiency results in increased activity of and results in increased localization of PRKCD protein]
|
CTD |
PMID:11424089 PMID:17171638 |
|
NCBI chr16:5,775,681...5,806,122
Ensembl chr16:5,769,215...5,799,352
|
|
G
|
Prkdc
|
protein kinase, DNA-activated, catalytic subunit
|
multiple interactions
|
ISO
|
PRKDC protein affects the susceptibility to [wortmannin co-treated with Benzo(a)pyrene]
|
CTD |
PMID:20888899 |
|
NCBI chr11:98,544,952...98,762,499
Ensembl chr11:85,040,792...85,257,952
|
|
G
|
Prpf19
|
pre-mRNA processing factor 19
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]
|
CTD |
PMID:20629186 |
|
NCBI chr 1:216,966,104...216,977,549
Ensembl chr 1:207,541,595...207,552,662
|
|
G
|
Pten
|
phosphatase and tensin homolog
|
multiple interactions
|
ISO EXP
|
Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Doxorubicin]; Wortmannin inhibits the reaction [PTEN protein results in increased susceptibility to Etoposide]; Wortmannin inhibits the reaction [tetrachlorodian results in decreased expression of PTEN mRNA] Wortmannin inhibits the reaction [nonylphenol results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of PTEN mRNA]]; Wortmannin inhibits the reaction [Zinc Sulfate promotes the reaction [PTEN protein binds to NEDD4 protein]]; Wortmannin inhibits the reaction [Zinc Sulfate results in decreased expression of PTEN protein]; Wortmannin inhibits the reaction [Zinc Sulfate results in increased ubiquitination of PTEN protein]
|
CTD |
PMID:17935137 PMID:20100827 PMID:27832966 PMID:32805344 PMID:36190352 |
|
NCBI chr 1:240,043,707...240,110,330
Ensembl chr 1:230,630,338...230,696,838
|
|
G
|
Ptger1
|
prostaglandin E receptor 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased expression of HIF1A protein]; wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]
|
CTD |
PMID:20335389 |
|
NCBI chr19:24,470,258...24,473,687
Ensembl chr19:24,467,532...24,473,559
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [PTGS2 protein results in decreased susceptibility to Carboplatin]; wortmannin inhibits the reaction [sodium arsenite results in increased expression of PTGS2 protein]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 mRNA]; wortmannin inhibits the reaction [Zinc results in increased expression of PTGS2 protein] Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 mRNA]; Wortmannin inhibits the reaction [o,p'-DDT results in increased expression of PTGS2 protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]]
|
CTD |
PMID:15980035 PMID:18089846 PMID:18840457 PMID:22952890 PMID:23968725 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:62,163,932...62,172,188
|
|
G
|
Ptk2
|
protein tyrosine kinase 2
|
multiple interactions
|
ISO EXP
|
[Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein; [wortmannin co-treated with Tetradecanoylphorbol Acetate] inhibits the reaction [oxotremorine M results in increased phosphorylation of PTK2 protein]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]]; Atropine inhibits the reaction [oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]]; oxotremorine M inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; oxotremorine M inhibits the reaction [[wortmannin co-treated with oxophenylarsine] results in increased phosphorylation of PTK2 protein]; oxotremorine M promotes the reaction [[Tetradecanoylphorbol Acetate co-treated with wortmannin] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [Testosterone results in increased phosphorylation of PTK2 protein] [wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein; KNG1 protein inhibits the reaction [[wortmannin co-treated with lysophosphatidic acid] results in increased phosphorylation of PTK2 protein]; wortmannin inhibits the reaction [KNG1 protein results in increased phosphorylation of PTK2 protein]
|
CTD |
PMID:10537051 PMID:16038899 |
|
NCBI chr 7:105,126,725...105,331,848
Ensembl chr 7:105,126,728...105,331,783
|
|
G
|
Pxn
|
paxillin
|
multiple interactions
|
ISO
|
[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]; Atropine inhibits the reaction [[oxotremorine M co-treated with wortmannin] inhibits the reaction [oxophenylarsine results in increased phosphorylation of PXN protein]]; wortmannin inhibits the reaction [oxotremorine M results in increased phosphorylation of PXN protein]
|
CTD |
PMID:10537051 |
|
NCBI chr12:41,060,791...41,107,952
Ensembl chr12:41,060,791...41,107,931
|
|
G
|
Rad23b
|
RAD23 homolog B, nucleotide excision repair protein
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Cisplatin results in increased expression of RAD23B protein]
|
CTD |
PMID:21742020 |
|
NCBI chr 5:70,090,232...70,128,340
Ensembl chr 5:70,090,232...70,128,319
|
|
G
|
Rad50
|
RAD50 double strand break repair protein
|
multiple interactions
|
ISO
|
[wortmannin co-treated with docetaxel] results in decreased expression of RAD50 protein
|
CTD |
PMID:20878124 |
|
NCBI chr10:37,809,353...37,861,309
Ensembl chr10:37,808,726...37,861,396
|
|
G
|
Raf1
|
Raf-1 proto-oncogene, serine/threonine kinase
|
multiple interactions
|
ISO
|
wortmannin promotes the reaction [hydroxyflutamide results in increased phosphorylation of RAF1 protein]; wortmannin promotes the reaction [ON123300 results in increased phosphorylation of RAF1 protein]
|
CTD |
PMID:24568969 PMID:28163245 |
|
NCBI chr 4:150,352,158...150,412,813
Ensembl chr 4:148,679,530...148,740,317
|
|
G
|
Rap1a
|
RAP1A, member of RAS oncogene family
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [ITGB2 protein results in increased activity of RAP1A protein]
|
CTD |
PMID:16963453 |
|
NCBI chr 2:195,896,967...195,974,851
Ensembl chr 2:193,208,635...193,286,501
|
|
G
|
Rb1
|
RB transcriptional corepressor 1
|
multiple interactions
|
ISO EXP
|
wortmannin inhibits the reaction [KITL protein results in increased phosphorylation of RB1 protein]; wortmannin inhibits the reaction [Vanadates results in increased phosphorylation of RB1 protein] Wortmannin inhibits the reaction [1,1-dimethylbutyl-1-deoxy-Delta(9)-THC inhibits the reaction [Magnesium deficiency results in decreased phosphorylation of RB1 protein]]; Wortmannin inhibits the reaction [[lead acetate results in increased abundance of Lead] which results in increased phosphorylation of RB1 protein]
|
CTD |
PMID:10849422 PMID:14971663 PMID:18353414 PMID:30542433 |
|
NCBI chr15:54,780,858...54,911,989
Ensembl chr15:48,371,296...48,502,302
|
|
G
|
Rel
|
REL proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Norepinephrine affects the localization of REL protein]; wortmannin inhibits the reaction [Norepinephrine promotes the reaction [REL protein binds to ICAM1 promoter]]
|
CTD |
PMID:23114885 |
|
NCBI chr14:97,690,105...97,721,194
Ensembl chr14:97,695,161...97,720,892
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions
|
ISO EXP
|
wortmannin inhibits the reaction [Ozone results in increased activity of [NFKB1 protein binds to RELA protein]]; wortmannin inhibits the reaction [Toluene 2,4-Diisocyanate results in increased expression of RELA protein] Wortmannin inhibits the reaction [Mevinphos results in increased activity of RELA protein]; Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of RELA protein]]
|
CTD |
PMID:17982072 PMID:18207479 PMID:24462917 PMID:32805344 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:202,924,945...202,935,484
|
|
G
|
Riox2
|
ribosomal oxygenase 2
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [arsenic trichloride results in increased expression of RIOX2 mRNA]
|
CTD |
PMID:24434654 |
|
NCBI chr11:40,861,365...40,884,782
Ensembl chr11:40,860,774...40,884,574
|
|
G
|
Rps6
|
ribosomal protein S6
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [[Dinoprostone binds to and results in increased activity of PTGER1 protein] which results in increased phosphorylation of RPS6 protein]; Wortmannin inhibits the reaction [[IL3 protein co-treated with CSF2 protein co-treated with FLT3LG protein co-treated with KITLG protein] results in increased phosphorylation of RPS6 protein]
|
CTD |
PMID:20335389 PMID:23001822 |
|
NCBI chr 5:106,417,680...106,420,540
Ensembl chr 5:101,371,136...101,374,602 Ensembl chr 5:101,371,136...101,374,602
|
|
G
|
Rps6kb1
|
ribosomal protein S6 kinase B1
|
multiple interactions decreases phosphorylation
|
EXP ISO
|
wortmannin inhibits the reaction [Cadmium Chloride results in increased phosphorylation of RPS6KB1 protein] Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased phosphorylation of RPS6KB1 protein]; Wortmannin inhibits the reaction [INS protein results in increased expression of RPS6KB1 protein modified form] wortmannin results in decreased phosphorylation of RPS6KB1 protein wortmannin inhibits the reaction [arsenite affects the activity of RPS6KB1 protein]
|
CTD |
PMID:14516795 PMID:20936651 PMID:21195169 PMID:25663935 PMID:32802178 |
|
NCBI chr10:71,817,794...71,865,211
Ensembl chr10:71,323,777...71,367,908
|
|
G
|
Rps6kb2
|
ribosomal protein S6 kinase B2
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Phosphatidic Acids results in increased activity of RPS6KB2 protein]
|
CTD |
PMID:12087098 |
|
NCBI chr 1:210,880,824...210,887,556
Ensembl chr 1:201,451,265...201,458,078
|
|
G
|
Scg2
|
secretogranin II
|
decreases activity
|
ISO
|
wortmannin results in decreased activity of SCG2 protein alternative form
|
CTD |
PMID:9473216 |
|
NCBI chr 9:80,803,074...80,808,646
Ensembl chr 9:80,803,075...80,821,097
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G
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Sct
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secretin
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multiple interactions
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EXP
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wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid analog]; wortmannin inhibits the reaction [SCT results in increased susceptibility to Ursodeoxycholic Acid]; wortmannin inhibits the reaction [Ursodeoxycholic Acid analog results in increased activity of SCT]
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CTD |
PMID:22194894 |
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NCBI chr 1:196,382,857...196,383,668
Ensembl chr 1:196,382,856...196,383,658
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G
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Selenop
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selenoprotein P
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increases expression
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ISO
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wortmannin results in increased expression of SELENOP protein
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CTD |
PMID:24535192 |
|
NCBI chr 2:54,225,736...54,236,022
Ensembl chr 2:52,498,339...52,508,852
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G
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Serpine1
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serpin family E member 1
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multiple interactions
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ISO
|
wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]
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CTD |
PMID:16458614 |
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NCBI chr12:25,237,977...25,248,356
Ensembl chr12:19,601,272...19,611,657
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G
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Serpinh1
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serpin family H member 1
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multiple interactions
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ISO
|
wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 mRNA]; wortmannin inhibits the reaction [cobaltous chloride results in decreased expression of SERPINH1 protein]
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CTD |
PMID:13679210 |
|
NCBI chr 1:163,055,630...163,063,177
Ensembl chr 1:153,643,510...153,650,801
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G
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Sftpc
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surfactant protein C
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decreases expression
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ISO
|
wortmannin results in decreased expression of SFTPC protein
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CTD |
PMID:15695173 |
|
NCBI chr15:52,006,274...52,009,324
Ensembl chr15:45,596,574...45,610,777
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G
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Sgk1
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serum/glucocorticoid regulated kinase 1
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Dexamethasone results in increased phosphorylation of SGK1 protein]
|
CTD |
PMID:21655274 |
|
NCBI chr 1:24,799,391...24,916,886
Ensembl chr 1:22,980,261...23,098,283
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G
|
Shbg
|
sex hormone binding globulin
|
multiple interactions
|
EXP
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wortmannin inhibits the reaction [nonylphenol results in increased expression of SHBG mRNA]
|
CTD |
PMID:27832966 |
|
NCBI chr10:54,831,716...54,849,162
Ensembl chr10:54,332,941...54,351,057
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G
|
Sirpa
|
signal-regulatory protein alpha
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]
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CTD |
PMID:12805067 |
|
NCBI chr 3:137,272,932...137,311,279
Ensembl chr 3:116,819,726...116,858,098
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G
|
Sirt1
|
sirtuin 1
|
multiple interactions
|
ISO
|
wortmannin promotes the reaction [arsenic disulfide results in decreased expression of SIRT1 protein] wortmannin inhibits the reaction [resveratrol inhibits the reaction [Lipopolysaccharides results in decreased expression of SIRT1 protein]]
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CTD |
PMID:18298901 PMID:22952890 |
|
NCBI chr20:25,305,953...25,328,000
Ensembl chr20:25,306,917...25,329,260
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G
|
Slc1a1
|
solute carrier family 1 member 1
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multiple interactions decreases activity
|
EXP
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wortmannin inhibits the reaction [Carbamazepine results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Pregabalin results in increased activity of SLC1A1 protein]; wortmannin inhibits the reaction [Progesterone results in increased activity of SLC1A1 protein] wortmannin results in decreased activity of SLC1A1 protein
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CTD |
PMID:16150575 PMID:22511482 PMID:23262392 PMID:23602688 PMID:24355585 |
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NCBI chr 1:235,963,455...236,043,572
Ensembl chr 1:226,549,842...226,630,402
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G
|
Slc2a4
|
solute carrier family 2 member 4
|
multiple interactions
|
EXP ISO
|
Wortmannin inhibits the reaction [4-hydroxyisoleucine results in increased localization of SLC2A4 protein]; Wortmannin inhibits the reaction [AICA ribonucleotide results in increased localization of SLC2A4 protein] wortmannin inhibits the reaction [INS1 protein affects the localization of SLC2A4 protein]
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CTD |
PMID:11978788 PMID:18591783 PMID:22610671 |
|
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:54,666,015...54,671,565
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|
G
|
Slc2a5
|
solute carrier family 2 member 5
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Fructose results in increased expression of and results in increased activity of SLC2A5 protein]
|
CTD |
PMID:15691865 |
|
NCBI chr 5:165,857,412...165,892,928
Ensembl chr 5:160,583,234...160,611,106
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G
|
Slc5a5
|
solute carrier family 5 member 5
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Carbamazepine promotes the reaction [Tretinoin results in increased expression of SLC5A5 protein]]
|
CTD |
PMID:20300827 |
|
NCBI chr16:18,580,705...18,590,692
Ensembl chr16:18,546,709...18,556,697
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|
G
|
Slc6a3
|
solute carrier family 6 member 3
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [SLC6A3 protein results in increased uptake of Dopamine]
|
CTD |
PMID:20875051 |
|
NCBI chr 1:31,537,990...31,578,962
Ensembl chr 1:29,709,443...29,750,413
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G
|
Socs3
|
suppressor of cytokine signaling 3
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 mRNA]; wortmannin inhibits the reaction [Gemfibrozil results in increased expression of SOCS3 protein]
|
CTD |
PMID:22685291 |
|
NCBI chr10:103,692,579...103,695,975
Ensembl chr10:103,193,537...103,197,787
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G
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Sod2
|
superoxide dismutase 2
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increases expression
|
EXP
|
wortmannin results in increased expression of SOD2 mRNA
|
CTD |
PMID:20596034 |
|
NCBI chr 1:50,043,323...50,050,168
Ensembl chr 1:47,636,528...47,645,189
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G
|
Sort1
|
sortilin 1
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multiple interactions increases ubiquitination
|
ISO
|
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [wortmannin results in increased degradation of SORT1 protein]; wortmannin inhibits the reaction [INS1 protein results in increased expression of SORT1 protein]; wortmannin results in decreased expression of and results in increased degradation of SORT1 protein wortmannin results in increased ubiquitination of SORT1 protein
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CTD |
PMID:25805502 |
|
NCBI chr 2:195,924,033...196,002,354
Ensembl chr 2:195,924,099...196,002,354
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G
|
Sp1
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Sp1 transcription factor
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multiple interactions decreases reaction
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ISO EXP
|
wortmannin inhibits the reaction [Etoposide results in increased phosphorylation of SP1 protein] wortmannin inhibits the reaction [estrogen increases expression of Sp1 mRNA] in rat uterus
|
CTD RGD |
PMID:17441964 PMID:17272396 |
RGD:152177689 |
NCBI chr 7:135,419,864...135,450,513
Ensembl chr 7:133,541,491...133,571,961
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|
G
|
Sqstm1
|
sequestosome 1
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multiple interactions increases expression decreases expression
|
ISO
|
[wortmannin co-treated with Ethanol] results in increased expression of SQSTM1 protein wortmannin results in increased expression of SQSTM1 protein wortmannin results in decreased expression of SQSTM1 protein
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CTD |
PMID:22459179 |
|
NCBI chr10:35,026,598...35,037,750
Ensembl chr10:34,525,519...34,536,673
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G
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Src
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SRC proto-oncogene, non-receptor tyrosine kinase
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multiple interactions
|
ISO
|
wortmannin inhibits the reaction [EGF protein results in increased phosphorylation of SRC protein]
|
CTD |
PMID:25856345 |
|
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:146,091,841...146,139,476
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G
|
Srebf1
|
sterol regulatory element binding transcription factor 1
|
multiple interactions
|
EXP
|
Wortmannin inhibits the reaction [AGT protein results in increased cleavage of SREBF1 protein]; Wortmannin inhibits the reaction [Glucose results in increased cleavage of SREBF1 protein]
|
CTD |
PMID:22031849 PMID:25398788 |
|
NCBI chr10:45,507,152...45,529,164
Ensembl chr10:45,007,637...45,029,650
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|
G
|
Srf
|
serum response factor
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of SRF mRNA]
|
CTD |
PMID:36190352 PMID:37992829 |
|
NCBI chr 9:21,924,050...21,933,338
Ensembl chr 9:14,426,472...14,435,733
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|
G
|
Star
|
steroidogenic acute regulatory protein
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [Atrazine promotes the reaction [FSHB protein results in increased expression of STAR mRNA]]; wortmannin inhibits the reaction [FSHB protein results in increased expression of STAR mRNA]
|
CTD |
PMID:25253736 |
|
NCBI chr16:72,969,824...72,974,447
Ensembl chr16:66,264,807...66,271,672
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|
G
|
Sts
|
steroid sulfatase
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid results in increased activity of STS protein]; wortmannin inhibits the reaction [AGN 195183 results in increased activity of STS protein]; wortmannin inhibits the reaction [IGF2 protein results in increased expression of STS mRNA]; wortmannin inhibits the reaction [tazarotene results in increased activity of STS protein]; wortmannin inhibits the reaction [Tretinoin results in increased activity of STS protein]
|
CTD |
PMID:16178010 PMID:24055520 |
|
NCBI chr X:42,225,131...42,233,403
Ensembl chr X:42,225,372...42,233,402
|
|
G
|
Tert
|
telomerase reverse transcriptase
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [Camptothecin results in increased phosphorylation of TERT protein]
|
CTD |
PMID:30851366 |
|
NCBI chr 1:31,465,766...31,488,650
Ensembl chr 1:29,637,506...29,659,561
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|
G
|
Tff1
|
trefoil factor 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of TFF1 mRNA]
|
CTD |
PMID:36190352 PMID:37992829 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
|
|
G
|
Tgif1
|
TGFB-induced factor homeobox 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [arsenic trioxide results in increased expression of TGIF1 protein]
|
CTD |
PMID:21649584 |
|
NCBI chr 9:110,748,094...110,757,714
Ensembl chr 9:110,720,921...110,757,802
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|
G
|
Th
|
tyrosine hydroxylase
|
multiple interactions
|
ISO EXP
|
wortmannin affects the reaction [HU 211 results in decreased expression of TH mRNA] [wortmannin co-treated with manganese chloride] results in decreased expression of TH protein
|
CTD |
PMID:18950629 PMID:23604964 |
|
NCBI chr 1:207,500,959...207,508,276
Ensembl chr 1:198,071,503...198,109,767
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|
G
|
Thra
|
thyroid hormone receptor alpha
|
multiple interactions
|
ISO
|
wortmannin binds to and results in decreased activity of THRA protein
|
CTD |
PMID:25752796 |
|
NCBI chr10:84,198,141...84,225,659
Ensembl chr10:83,700,755...83,729,936
|
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G
|
Timp2
|
TIMP metallopeptidase inhibitor 2
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of TIMP2 mRNA]
|
CTD |
PMID:22841774 |
|
NCBI chr10:104,041,604...104,089,214
Ensembl chr10:103,531,505...103,590,611
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|
G
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Tjp1
|
tight junction protein 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [telmisartan affects the localization of TJP1 protein]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 mRNA]; wortmannin inhibits the reaction [telmisartan results in decreased expression of TJP1 protein]
|
CTD |
PMID:19252288 |
|
NCBI chr 1:128,260,330...128,505,018
Ensembl chr 1:118,849,838...119,094,432
|
|
G
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Tnf
|
tumor necrosis factor
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multiple interactions increases response to substance
|
ISO EXP
|
Wortmannin inhibits the reaction [Ciprofloxacin inhibits the reaction [[IL1A protein co-treated with TNF protein co-treated with IFNG protein] results in increased abundance of Nitric Oxide]]; Wortmannin inhibits the reaction [Dieldrin results in increased expression of TNF mRNA]; Wortmannin inhibits the reaction [SIRPA protein inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased expression of and results in increased secretion of SERPINE1 protein]; Wortmannin inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein]; Wortmannin promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] Wortmannin results in increased susceptibility to TNF protein Wortmannin inhibits the reaction [Phycocyanin inhibits the reaction [Streptozocin results in increased expression of TNF protein]]; Wortmannin inhibits the reaction [TNF protein results in increased phosphorylation of AKT1 protein] Wortmannin inhibits the reaction [4-hydroxyisoleucine inhibits the reaction [TNF protein results in decreased phosphorylation of AKT1 protein]]; Wortmannin inhibits the reaction [EDN1 protein inhibits the reaction [TNF protein results in increased expression of NOS2 protein]]; Wortmannin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]]; Wortmannin inhibits the reaction [Resveratrol inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]]
|
CTD |
PMID:12805067 PMID:12839867 PMID:16458614 PMID:16968468 PMID:17464197 PMID:19810018 PMID:22556157 PMID:22952890 PMID:25352548 PMID:26887316 PMID:31068361 PMID:31445927 PMID:32805344 More...
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|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,622,011...3,624,629
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|
G
|
Tp53
|
tumor protein p53
|
multiple interactions decreases phosphorylation
|
ISO EXP
|
Wortmannin inhibits the reaction [2-chloroethyl ethyl sulfide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [3,3'-diindolylmethane results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Asbestos, Serpentine results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Doxorubicin promotes the reaction [ATM protein results in increased phosphorylation of TP53 protein]]; Wortmannin inhibits the reaction [Mustard Gas results in increased expression of TP53 protein]; Wortmannin inhibits the reaction [Mustard Gas results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Nitric Oxide results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [Resveratrol results in increased phosphorylation of TP53 protein]; Wortmannin inhibits the reaction [spermine nitric oxide complex results in increased phosphorylation of TP53 protein]; Wortmannin promotes the reaction [arsenic disulfide results in increased expression of and results in increased phosphorylation of TP53 protein]; Wortmannin results in decreased phosphorylation of and results in decreased expression of TP53 protein wortmannin results in decreased phosphorylation of TP53 protein wortmannin inhibits the reaction [Diethylnitrosamine results in increased expression of TP53 protein]; wortmannin inhibits the reaction [Diethylnitrosamine results in increased phosphorylation of TP53 protein]
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CTD |
PMID:11751435 PMID:12676607 PMID:15489221 PMID:15837074 PMID:16024610 PMID:17534123 PMID:18298901 PMID:19111594 PMID:22119920 PMID:22290291 More...
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|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,300,048...54,311,524
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G
|
Tp73
|
tumor protein p73
|
multiple interactions
|
ISO
|
wortmannin promotes the reaction [Cisplatin results in increased expression of TP73 protein]; wortmannin promotes the reaction [Doxorubicin results in increased expression of TP73 protein]
|
CTD |
PMID:21214929 |
|
NCBI chr 5:169,903,801...169,988,075
Ensembl chr 5:164,621,377...164,681,128
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|
G
|
Tpp2
|
tripeptidyl peptidase 2
|
multiple interactions
|
ISO
|
wortmannin promotes the reaction [Etoposide affects the localization of TPP2 protein]
|
CTD |
PMID:20643100 |
|
NCBI chr 9:46,046,712...46,128,157
Ensembl chr 9:46,046,632...46,128,157
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|
G
|
Trpv1
|
transient receptor potential cation channel, subfamily V, member 1
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [NGF results in increased localization of TRPV1 protein]
|
CTD |
PMID:16319926 |
|
NCBI chr10:58,349,936...58,375,021
Ensembl chr10:57,851,428...57,876,513
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|
G
|
Txnrd1
|
thioredoxin reductase 1
|
multiple interactions
|
ISO
|
Wortmannin inhibits the reaction [[formononetin co-treated with Hydrogen Peroxide] results in increased expression of TXNRD1 mRNA]
|
CTD |
PMID:34077701 |
|
NCBI chr 7:22,717,620...22,802,553
Ensembl chr 7:20,830,045...20,907,863
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G
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Tyr
|
tyrosinase
|
multiple interactions
|
ISO
|
[Colforsin co-treated with Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] promotes the reaction [Colforsin results in increased expression of TYR protein]; [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in increased expression of TYR protein [Wortmannin co-treated with 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one] results in decreased expression of TYR protein
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CTD |
PMID:28849034 |
|
NCBI chr 1:150,527,687...150,622,857
Ensembl chr 1:141,115,036...141,210,207
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G
|
Usp7
|
ubiquitin specific peptidase 7
|
multiple interactions
|
ISO
|
benzyloxycarbonylleucyl-leucyl-leucine aldehyde inhibits the reaction [Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]]; Wortmannin inhibits the reaction [[[sodium arsenite results in increased abundance of Arsenic] which co-treated with Benzo(a)pyrene] results in increased expression of USP7 protein]
|
CTD |
PMID:32802178 |
|
NCBI chr10:6,880,684...6,925,355
Ensembl chr10:6,828,795...6,925,355
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G
|
Vegfa
|
vascular endothelial growth factor A
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multiple interactions decreases secretion decreases reaction
|
ISO EXP
|
[4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; [4'-hydroxywogonin co-treated with Wortmannin] inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [4-hydroxyestradiol results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [4-tert-octylphenol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [butylbenzyl phthalate results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [cobaltous chloride results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [CYP4Z1 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Dieldrin results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Estradiol results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [Genistein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IGF1 protein results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of and results in increased secretion of VEGFA protein]; Wortmannin inhibits the reaction [IL6 protein results in increased expression of VEGFA mRNA]; Wortmannin inhibits the reaction [Oxaliplatin results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [sodium arsenite results in increased expression of VEGFA protein]; Wortmannin inhibits the reaction [tetrachlorodian results in increased expression of VEGFA mRNA] Wortmannin results in decreased secretion of VEGFA protein wortmannin inhibits the reaction [estrogen increases expression of Vegfa mRNA] in rat uterus
|
CTD RGD |
PMID:13679210 PMID:15050414 PMID:16499871 PMID:18252963 PMID:18790786 PMID:19779139 PMID:22841774 PMID:23968725 PMID:30217479 PMID:36190352 PMID:17272396 More...
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RGD:152177689 |
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:14,955,300...14,970,641
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|
G
|
Vim
|
vimentin
|
decreases expression
|
ISO
|
wortmannin results in decreased expression of VIM protein
|
CTD |
PMID:25856345 |
|
NCBI chr17:81,577,261...81,585,746
Ensembl chr17:76,668,647...76,677,187
|
|
G
|
Xrcc5
|
X-ray repair cross complementing 5
|
multiple interactions
|
ISO
|
[wortmannin co-treated with docetaxel] results in decreased expression of XRCC5 protein
|
CTD |
PMID:20878124 |
|
NCBI chr 9:73,955,216...74,044,020
Ensembl chr 9:73,955,216...74,044,018
|
|
G
|
Xrcc6
|
X-ray repair cross complementing 6
|
multiple interactions
|
ISO
|
[wortmannin co-treated with docetaxel] results in decreased expression of XRCC6 protein
|
CTD |
PMID:20878124 |
|
NCBI chr 7:115,423,026...115,443,884
Ensembl chr 7:113,543,057...113,563,762
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|
G
|
Yap1
|
Yes1 associated transcriptional regulator
|
multiple interactions
|
ISO
|
wortmannin promotes the reaction [Cisplatin results in increased expression of YAP1 protein modified form]; wortmannin promotes the reaction [Doxorubicin results in increased expression of YAP1 protein modified form]
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CTD |
PMID:21214929 |
|
NCBI chr 8:13,380,551...13,451,640
Ensembl chr 8:5,095,722...5,167,010
|
|
G
|
Ywhab
|
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
|
multiple interactions
|
EXP
|
wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to CDC5L protein]]; wortmannin inhibits the reaction [NGF protein promotes the reaction [YWHAB protein binds to PRPF19 protein modified form]]
|
CTD |
PMID:20629186 |
|
NCBI chr 3:152,659,663...152,682,105
Ensembl chr 3:152,659,651...152,682,105
|
|
G
|
Zfp143
|
zinc finger protein 143
|
multiple interactions
|
ISO
|
wortmannin inhibits the reaction [IGF1 protein results in increased expression of ZNF143 protein]
|
CTD |
PMID:20733350 |
|
NCBI chr 1:164,109,041...164,144,902
Ensembl chr 1:164,109,116...164,144,902
|
|