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Gene: Optn (optineurin) Mus musculus
Symbol: Optn
Name: optineurin
Description: Exhibits K63-linked polyubiquitin modification-dependent protein binding activity. Involved in cellular protein localization and negative regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to the perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Is expressed in several structures, including alimentary system; eye; musculoskeletal system; nervous system; and urinary system. Orthologous to human OPTN (optineurin); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 1,1-dichloroethene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930441O07Rik; FIP2; HYPL; NRP; TFIIIA-INTP
Homo sapiens (human) : OPTN (optineurin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Optn (optineurin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Optn (optineurin)
Pan paniscus (bonobo/pygmy chimpanzee) : OPTN (optineurin)
Canis lupus familiaris (dog) : OPTN (optineurin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101956249 (optineurin)
Sus scrofa (pig) : OPTN (optineurin)
Chlorocebus sabaeus (African green monkey) : OPTN (optineurin)
Heterocephalus glaber (naked mole-rat) : Optn (optineurin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl25,020,642 - 5,064,051 (-)EnsemblGRCm38mm10GRCm38
GRCm3825,020,521 - 5,064,399 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3724,941,688 - 4,984,984 (-)NCBIGRCm37mm9NCBIm37
MGSCv3624,937,914 - 4,981,210 (-)NCBImm8
Celera24,975,403 - 5,009,506 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Optn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733470
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.