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Gene: Optn (optineurin) Mus musculus
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Symbol: Optn
Name: optineurin
Description: Exhibits K63-linked polyubiquitin modification-dependent protein binding activity. Involved in cellular protein localization and negative regulation of I-kappaB kinase/NF-kappaB signaling. Localizes to the perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Paget's disease of bone; amyotrophic lateral sclerosis (multiple); and glaucoma (multiple). Is expressed in several structures, including alimentary system; eye; musculoskeletal system; nervous system; and urinary system. Orthologous to human OPTN (optineurin); PARTICIPATES IN mitochondrial autophagy pathway; INTERACTS WITH 1,1-dichloroethene; 2,2',4,4'-Tetrabromodiphenyl ether; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 4930441O07Rik; FIP2; HYPL; NRP; TFIIIA-INTP
Orthologs:
Homo sapiens (human) : OPTN (optineurin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Optn (optineurin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Optn (optineurin)
Pan paniscus (bonobo/pygmy chimpanzee) : OPTN (optineurin)
Canis lupus familiaris (dog) : OPTN (optineurin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101956249 (optineurin)
Sus scrofa (pig) : OPTN (optineurin)
Chlorocebus sabaeus (African green monkey) : OPTN (optineurin)
Heterocephalus glaber (naked mole-rat) : Optn (optineurin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl25,020,642 - 5,064,051 (-)EnsemblGRCm38mm10GRCm38
GRCm3825,020,521 - 5,064,399 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3724,941,688 - 4,984,984 (-)NCBIGRCm37mm9NCBIm37
MGSCv3624,937,914 - 4,981,210 (-)NCBImm8
Celera24,975,403 - 5,009,506 (-)NCBICelera
Cytogenetic Map2A1NCBI
cM Map23.15NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Optn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 733470
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.