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Gene: Ticam2 (toll-like receptor adaptor molecule 2) Mus musculus
Symbol: Ticam2
Name: toll-like receptor adaptor molecule 2
Description: Exhibits phospholipid binding activity. Involved in several processes, including positive regulation of cytokine production; positive regulation of interleukin-18-mediated signaling pathway; and response to interleukin-12. Localizes to endosome and plasma membrane. Is expressed in testis and ureter. Orthologous to several human genes including TMED7-TICAM2 (TMED7-TICAM2 readthrough); PARTICIPATES IN interleukin-1 signaling pathway; Toll-like receptor signaling pathway; INTERACTS WITH chloroquine; ciguatoxin CTX1B; lipopolysaccharide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B430113A10; MGC107370; TICAM-2; TIR domain-containing adapter molecule 2; TIR domain-containing adapter protein; Tirp; Toll-interleukin I receptor domain (TIR)-containing adaptor molecule (TICAM) 2; toll/interleukin-1 receptor domain-containing protein; TRAM; Trif; TRIF-related adapter molecule TRAM; TRIF-related adaptor molecule
Homo sapiens (human) : TICAM2 (toll like receptor adaptor molecule 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ticam2 (toll-like receptor adaptor molecule 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ticam2 (toll like receptor adaptor molecule 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TICAM2 (toll like receptor adaptor molecule 2)
Canis lupus familiaris (dog) : TICAM2 (toll like receptor adaptor molecule 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ticam2 (toll like receptor adaptor molecule 2)
Sus scrofa (pig) : TICAM2 (toll like receptor adaptor molecule 2)
Chlorocebus sabaeus (African green monkey) : TICAM2 (toll like receptor adaptor molecule 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38.p6 Ensembl1846,557,291 - 46,574,533 (-)EnsemblGRCm38mm10GRCm38
GRCm381846,558,231 - 46,574,533 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371846,717,885 - 46,734,187 (-)NCBIGRCm37mm9NCBIm37
MGSCv361846,683,562 - 46,699,863 (-)NCBImm8
Celera1847,917,939 - 47,934,160 (-)NCBICelera
Cytogenetic Map18CNCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ticam2
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1550939
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2020-07-28
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.