Ern1 (endoplasmic reticulum (ER) to nucleus signalling 1) - Rat Genome Database

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Gene: Ern1 (endoplasmic reticulum (ER) to nucleus signalling 1) Mus musculus
Analyze
Symbol: Ern1
Name: endoplasmic reticulum (ER) to nucleus signalling 1
RGD ID: 1558600
MGI Page MGI
Description: Enables endoribonuclease activity; protein homodimerization activity; and protein serine/threonine kinase activity. Involved in several processes, including IRE1-mediated unfolded protein response; mRNA cleavage; and positive regulation of nitrogen compound metabolic process. Acts upstream of or within endoplasmic reticulum unfolded protein response; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and protein autophosphorylation. Located in endoplasmic reticulum membrane; mitochondrion; and nuclear inner membrane. Part of AIP1-IRE1 complex. Is expressed in several structures, including brain; connective tissue; gut; hemolymphoid system gland; and tooth. Human ortholog(s) of this gene implicated in hepatocellular carcinoma. Orthologous to human ERN1 (endoplasmic reticulum to nucleus signaling 1); PARTICIPATES IN endoplasmic reticulum stress - the unfolded protein response pathway; Alzheimer's disease pathway; Endoplasmic Reticulum-associated degradation pathway; INTERACTS WITH (S)-nicotine; 1,2-dichloroethane; 1,2-dimethylhydrazine.
Type: protein-coding
RefSeq Status: PROVISIONAL
Also known as: 9030414B18Rik; AI225830; C85377; endoplasmic reticulum-to-nucleus signaling 1; inositol-requiring 1 alpha; inositol-requiring protein 1; Ir; Ire; ire1-alpha; Ire1a; Ire1alpha; Ire1p; serine/threonine-protein kinase/endoribonuclease IRE1
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,285,474 - 106,378,701 (-)NCBIGRCm39mm39
GRCm39 Ensembl11106,285,476 - 106,378,678 (-)Ensembl
GRCm3811106,397,620 - 106,487,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,394,650 - 106,487,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,258,934 - 106,349,110 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611106,213,710 - 106,303,886 (-)NCBImm8
Celera11118,128,975 - 118,219,164 (-)NCBICelera
Cytogenetic Map11E1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-schisandrin B  (ISO)
(S)-nicotine  (EXP)
(Z)-3-butylidenephthalide  (ISO)
1,2-dichloroethane  (EXP)
1,2-dimethylhydrazine  (EXP)
1,4-dithiothreitol  (ISO)
1-[2-(3,4-dichlorophenyl)ethyl]-4-methylpiperazine  (EXP)
1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine  (EXP,ISO)
1-naphthyl isothiocyanate  (ISO)
15-acetyldeoxynivalenol  (ISO)
17beta-estradiol  (ISO)
17beta-hydroxy-5alpha-androstan-3-one  (ISO)
1H-pyrazole  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-dichlorophenol  (EXP)
2-amino-2-deoxy-D-glucopyranose  (EXP)
2-hydroxypropanoic acid  (ISO)
2-methyl-6-(phenylethynyl)pyridine  (ISO)
3,3',5,5'-tetrabromobisphenol A  (EXP)
3,4-methylenedioxymethamphetamine  (EXP)
3-acetyldeoxynivalenol  (ISO)
3-chloropropane-1,2-diol  (ISO)
3H-1,2-dithiole-3-thione  (ISO)
4-hydroxynon-2-enal  (EXP)
4-phenylbutyric acid  (ISO)
5-fluorouracil  (ISO)
acetamide  (ISO)
acrylamide  (ISO)
ADP  (EXP)
aflatoxin B1  (EXP)
aldehydo-D-glucosamine  (EXP)
aldehydo-D-glucose  (ISO)
all-trans-retinoic acid  (EXP,ISO)
allopurinol  (ISO)
amiloride  (EXP)
amiodarone  (EXP,ISO)
amosite asbestos  (ISO)
anthra[1,9-cd]pyrazol-6(2H)-one  (ISO)
apigenin  (EXP)
aristolochic acid  (ISO)
arsenous acid  (ISO)
atrazine  (ISO)
Azaspiracid  (ISO)
baicalin  (EXP)
benomyl  (ISO)
benzo[a]pyrene  (ISO)
benzo[a]pyrene diol epoxide I  (ISO)
beta-D-glucosamine  (EXP)
bicuculline  (EXP)
bisphenol A  (EXP,ISO)
bortezomib  (ISO)
brefeldin A  (EXP)
Butylparaben  (ISO)
butyric acid  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
caffeine  (EXP)
Calcimycin  (ISO)
calix[6]arene  (ISO)
Candesartan cilexetil  (ISO)
cannabidiol  (EXP)
cannabigerol  (EXP)
cantharidin  (ISO)
capsaicin  (ISO)
carbamazepine  (ISO)
carbon nanotube  (EXP,ISO)
cerulenin  (ISO)
ceruletide  (ISO)
chloroacetic acid  (EXP)
chloropicrin  (ISO)
choline  (EXP)
chrysophanol  (ISO)
cisplatin  (ISO)
cobalt dichloride  (ISO)
cocaine  (ISO)
copper atom  (ISO)
copper(0)  (ISO)
copper(II) sulfate  (ISO)
curcumin  (ISO)
cycloheximide  (ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (ISO)
Deguelin  (ISO)
demethoxycurcumin  (ISO)
deoxynivalenol  (EXP,ISO)
desferrioxamine B  (ISO)
diarsenic trioxide  (ISO)
diclofenac  (ISO)
dihydrocapsaicin  (ISO)
dinophysistoxin 1  (ISO)
dioxygen  (EXP)
edaravone  (ISO)
endosulfan  (ISO)
epoxomicin  (EXP)
erastin  (EXP)
ethanol  (EXP,ISO)
ferric ammonium citrate  (ISO)
ferric oxide  (EXP)
flufenoxuron  (EXP)
fluoranthene  (EXP)
folic acid  (EXP)
formaldehyde  (ISO)
gadolinium trichloride  (ISO)
gamma-aminobutyric acid  (EXP)
geraniol  (ISO)
ginsenoside Rg1  (ISO)
glucose  (ISO)
glycyrrhetinate  (ISO)
glycyrrhetinic acid  (ISO)
glyphosate  (ISO)
gold atom  (ISO)
gold(0)  (ISO)
Guanabenz  (ISO)
hexadecanoic acid  (EXP,ISO)
homocysteine  (ISO)
hydrogen peroxide  (ISO)
hydroxychloroquine  (ISO)
indometacin  (ISO)
L-1,4-dithiothreitol  (ISO)
L-methionine  (EXP)
lead diacetate  (EXP,ISO)
leflunomide  (ISO)
linuron  (EXP,ISO)
lipopolysaccharide  (ISO)
luteolin  (ISO)
lycopene  (ISO)
manganese(II) chloride  (ISO)
melatonin  (ISO)
metacetamol  (EXP)
methamphetamine  (EXP,ISO)
methotrexate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (ISO)
methyltestosterone  (ISO)
minocycline  (ISO)
mithramycin  (ISO)
MK-2206  (ISO)
morusin  (ISO)
muscimol  (EXP)
N-acetyl-L-cysteine  (EXP,ISO)
N-benzyloxycarbonyl-L-leucyl-L-leucyl-L-leucinal  (ISO)
N-methyl-4-phenylpyridinium  (ISO)
naltrexone  (ISO)
nicotine  (EXP)
Norbinaltorphimine  (ISO)
okadaic acid  (ISO)
oleic acid  (ISO)
orlistat  (ISO)
oxaliplatin  (ISO)
oxidopamine  (ISO)
paracetamol  (EXP,ISO)
paraquat  (ISO)
perfluorononanoic acid  (ISO)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (ISO)
pirinixic acid  (EXP,ISO)
poly(guanylic acid)  (ISO)
potassium iodide  (ISO)
pregnenolone 16alpha-carbonitrile  (ISO)
proanthocyanidin  (ISO)
propiconazole  (EXP)
pyrazinecarboxamide  (ISO)
quercetin  (ISO)
rac-lactic acid  (ISO)
resveratrol  (ISO)
rifampicin  (ISO)
rotenone  (ISO)
SCH 23390  (ISO)
sertraline  (ISO)
silicon dioxide  (ISO)
sincalide  (ISO)
sirolimus  (EXP,ISO)
sodium arsenite  (EXP,ISO)
sodium fluoride  (EXP,ISO)
streptozocin  (ISO)
succimer  (EXP)
sulindac  (ISO)
T-2 toxin  (EXP,ISO)
tacrolimus hydrate  (EXP)
taurine  (ISO)
tauroursodeoxycholic acid  (EXP)
tert-butyl hydroperoxide  (ISO)
tetrachloromethane  (EXP,ISO)
thapsigargin  (EXP,ISO)
thymoquinone  (ISO)
titanium dioxide  (ISO)
Tributyltin oxide  (ISO)
tris(2-butoxyethyl) phosphate  (ISO)
troglitazone  (EXP,ISO)
tunicamycin  (EXP,ISO)
urethane  (ISO)
ursolic acid  (ISO)
valproic acid  (ISO)
valsartan  (ISO)
vemurafenib  (ISO)
vinclozolin  (ISO)
vincristine  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

References

References - curated
1. Archer KJ, etal., Mol Genet Genomics. 2010 Apr;283(4):341-9. doi: 10.1007/s00438-010-0522-y. Epub 2010 Feb 18.
2. Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
3. Ko MS, etal., Development 2000 Apr;127(8):1737-49.
4. Liu A, etal., Sci Rep. 2019 Dec 13;9(1):19043. doi: 10.1038/s41598-019-55557-1.
5. Liu J, etal., Int J Mol Med. 2018 Nov;42(5):2891-2902. doi: 10.3892/ijmm.2018.3858. Epub 2018 Sep 5.
6. Liu J, etal., Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2017 Oct;33(10):1316-1322.
7. Lu JF, etal., Fa Yi Xue Za Zhi. 2018 Aug;34(4):347-351. doi: 10.12116/j.issn.1004-5619.2018.04.001. Epub 2018 Aug 25.
8. Lyu X, etal., Cancer Sci. 2019 Aug;110(8):2471-2484. doi: 10.1111/cas.14094. Epub 2019 Jul 3.
9. MGD data from the GO Consortium
10. Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
11. Pipeline to import KEGG annotations from KEGG into RGD
12. Ren F, etal., J Viral Hepat. 2016 Jan;23(1):23-31. doi: 10.1111/jvh.12438. Epub 2015 Jul 31.
13. RGD automated import pipeline
14. RGD automated import pipeline for gene-chemical interactions
15. Tan Z, etal., J Neuroinflammation. 2018 Sep 21;15(1):275. doi: 10.1186/s12974-018-1311-5.
16. Wang S and Kaufman RJ, J Cell Biol. 2012 Jun 25;197(7):857-67. doi: 10.1083/jcb.201110131.
17. Yang H, etal., Autophagy. 2020 Feb;16(2):271-288. doi: 10.1080/15548627.2019.1606647. Epub 2019 Apr 21.
18. Yuan F, etal., Biomed Res Int. 2019 Nov 20;2019:9276831. doi: 10.1155/2019/9276831. eCollection 2019.
Additional References at PubMed
PMID:9755171   PMID:10349636   PMID:10512203   PMID:10650002   PMID:10882126   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11146108   PMID:11430819   PMID:11780124   PMID:11850408  
PMID:12020828   PMID:12446770   PMID:12477932   PMID:12520002   PMID:14610273   PMID:15601821   PMID:15690081   PMID:15840001   PMID:16141072   PMID:16141073   PMID:16581782   PMID:16645094  
PMID:16680093   PMID:16950141   PMID:17030611   PMID:17035634   PMID:17090218   PMID:17367944   PMID:17765679   PMID:17991856   PMID:18035051   PMID:18049481   PMID:18281285   PMID:18286202  
PMID:18330477   PMID:19135427   PMID:19139267   PMID:19328063   PMID:19339988   PMID:19490910   PMID:19633360   PMID:19805353   PMID:19911006   PMID:19996103   PMID:20103773   PMID:20146926  
PMID:20221394   PMID:20661282   PMID:20702765   PMID:20798350   PMID:20850991   PMID:20885949   PMID:21267068   PMID:21284983   PMID:21385877   PMID:21407177   PMID:21415858   PMID:21447637  
PMID:21555585   PMID:21677750   PMID:21757700   PMID:21873635   PMID:21896783   PMID:21911379   PMID:21926971   PMID:22128176   PMID:22215619   PMID:22291093   PMID:22431749   PMID:22510886  
PMID:22773666   PMID:22883233   PMID:22961085   PMID:23028046   PMID:23040069   PMID:23040070   PMID:23042294   PMID:23144714   PMID:23184933   PMID:23235147   PMID:23237951   PMID:23314846  
PMID:23395094   PMID:23473031   PMID:23541586   PMID:23724040   PMID:23803178   PMID:23816533   PMID:23942232   PMID:23950715   PMID:23979843   PMID:24043762   PMID:24089213   PMID:24100031  
PMID:24242955   PMID:24441789   PMID:24508390   PMID:24670948   PMID:24797433   PMID:24853417   PMID:24863879   PMID:24915138   PMID:24945730   PMID:24951540   PMID:25164867   PMID:25170079  
PMID:25366967   PMID:25457211   PMID:25476903   PMID:25821218   PMID:25844898   PMID:25925952   PMID:25956028   PMID:25986605   PMID:26031337   PMID:26106220   PMID:26147683   PMID:26173459  
PMID:26173697   PMID:26193638   PMID:26228140   PMID:26240153   PMID:26337904   PMID:26410627   PMID:26446798   PMID:26469762   PMID:26551274   PMID:26568450   PMID:26816051   PMID:26971994  
PMID:27040500   PMID:27052593   PMID:27283502   PMID:27558934   PMID:27587433   PMID:27626662   PMID:27634225   PMID:27743894   PMID:27797960   PMID:27938665   PMID:28028078   PMID:28082357  
PMID:28128204   PMID:28167662   PMID:28346409   PMID:28380378   PMID:28416388   PMID:28459443   PMID:28474670   PMID:28550308   PMID:28588082   PMID:28825721   PMID:29356058   PMID:29400713  
PMID:29451493   PMID:29457838   PMID:29506314   PMID:29507125   PMID:29511123   PMID:29717162   PMID:29764990   PMID:29907570   PMID:30013108   PMID:30111834   PMID:30146262   PMID:30305738  
PMID:30352954   PMID:30559399   PMID:30635284   PMID:30655546   PMID:30687308   PMID:30745418   PMID:30773986   PMID:30778220   PMID:30819965   PMID:30842412   PMID:30880003   PMID:30885990  
PMID:30963569   PMID:31086333   PMID:31110288   PMID:31123148   PMID:31320508   PMID:31368599   PMID:31369074   PMID:31921161   PMID:31965139   PMID:32220307   PMID:32243868   PMID:32325033  
PMID:32409639   PMID:32520957   PMID:32629174   PMID:32758541   PMID:32813318   PMID:32930709   PMID:32967957   PMID:33010578   PMID:33361822   PMID:33605987   PMID:33610548   PMID:33691254  


Genomics

Comparative Map Data
Ern1
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3911106,285,474 - 106,378,701 (-)NCBIGRCm39mm39
GRCm39 Ensembl11106,285,476 - 106,378,678 (-)Ensembl
GRCm3811106,397,620 - 106,487,796 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl11106,394,650 - 106,487,852 (-)EnsemblGRCm38mm10GRCm38
MGSCv3711106,258,934 - 106,349,110 (-)NCBIGRCm37mm9NCBIm37
MGSCv3611106,213,710 - 106,303,886 (-)NCBImm8
Celera11118,128,975 - 118,219,164 (-)NCBICelera
Cytogenetic Map11E1NCBI
ERN1
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1764,039,080 - 64,130,819 (-)EnsemblGRCh38hg38GRCh38
GRCh381764,039,142 - 64,132,469 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371762,116,502 - 62,207,504 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361759,474,122 - 59,561,234 (-)NCBINCBI36hg18NCBI36
Celera1756,508,473 - 56,595,582 (-)NCBI
Cytogenetic Map17q23.3NCBI
HuRef1757,488,466 - 57,575,481 (-)NCBIHuRef
CHM1_11762,184,805 - 62,271,973 (-)NCBICHM1_1
Ern1
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.21091,326,889 - 91,421,201 (-)NCBImRatBN7.2
Rnor_6.0 Ensembl1094,588,555 - 94,681,914 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.01094,588,555 - 94,682,072 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.01094,336,640 - 94,429,967 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41095,794,488 - 95,855,895 (-)NCBIRGSC3.4rn4RGSC3.4
Celera1090,003,932 - 90,064,578 (-)NCBICelera
Cytogenetic Map10q32.1NCBI
Ern1
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049554787,751,830 - 7,799,460 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049554787,720,664 - 7,803,662 (+)NCBIChiLan1.0ChiLan1.0
ERN1
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11763,226,949 - 63,317,825 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1763,226,949 - 63,317,825 (-)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01758,132,889 - 58,224,012 (-)NCBIMhudiblu_PPA_v0panPan3
ERN1
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1911,930,614 - 12,006,724 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl911,934,965 - 12,006,814 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha912,825,652 - 12,903,073 (-)NCBI
ROS_Cfam_1.0913,591,579 - 13,669,839 (-)NCBI
UMICH_Zoey_3.1912,538,344 - 12,616,358 (-)NCBI
UNSW_CanFamBas_1.0914,915,804 - 14,993,944 (+)NCBI
UU_Cfam_GSD_1.0914,918,080 - 14,996,082 (+)NCBI
Ern1
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440560214,488,687 - 14,581,401 (+)NCBI
SpeTri2.0NW_0049365414,613,197 - 4,705,911 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
ERN1
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1214,881,923 - 14,997,426 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11214,881,913 - 14,963,290 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21214,918,929 - 14,954,855 (+)NCBISscrofa10.2Sscrofa10.2susScr3
ERN1
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.11657,145,080 - 57,233,757 (+)NCBI
ChlSab1.1 Ensembl1657,145,191 - 57,236,230 (+)Ensembl
Vero_WHO_p1.0NW_02366607727,756,105 - 27,847,969 (+)NCBI
Ern1
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046248491,521,996 - 1,625,878 (-)NCBI

Position Markers
RH127178  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,397,352 - 106,397,569UniSTSGRCm38
MGSCv3711106,258,666 - 106,258,883UniSTSGRCm37
Celera11118,128,707 - 118,128,924UniSTS
Cytogenetic Map11E1UniSTS
Whitehead/MRC_RH111433.02UniSTS
AU016754  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,413,383 - 106,413,510UniSTSGRCm38
MGSCv3711106,274,697 - 106,274,824UniSTSGRCm37
Celera11118,144,738 - 118,144,865UniSTS
Cytogenetic Map11E1UniSTS
Whitehead/MRC_RH111434.96UniSTS
RH135977  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,395,811 - 106,396,014UniSTSGRCm38
MGSCv3711106,257,125 - 106,257,328UniSTSGRCm37
Celera11118,127,166 - 118,127,369UniSTS
Cytogenetic Map11E1UniSTS
Ern1  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm3811106,397,652 - 106,397,861UniSTSGRCm38
MGSCv3711106,258,966 - 106,259,175UniSTSGRCm37
Celera11118,129,007 - 118,129,216UniSTS
Cytogenetic Map11E1UniSTS
cM Map11 UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357859Lvrq7_mliver weight QTL 7 (mouse)Not determined1112318637118131898Mouse
39128214Lwq20_mliver weight QTL 20 (mouse)1112318637118131898Mouse
4141367Inf1_macute ozone induced inflammation (mouse)Not determined44739211113167183Mouse
4142121Tmc1m2_mTmc1 modifier 2 (mouse)Not determined1156973201114267131Mouse
27226730Tibmd1_mtibia midshaft diameter 1, 5 week (mouse)1162700000109500000Mouse
1301310Tmevd5_mTheiler's murine encephalomyelitis virus induced demyelinating disease susceptibility 5 (mouse)Not determined1172835299106835463Mouse
4142348Pstc2_mperiosteal circumference 2 (mouse)Not determined1172927789106927907Mouse
10043866Adip19_madiposity 19 (mouse)Not determined1172927789106927907Mouse
11038695Par8_mpulmonary adenoma resistance 8 (mouse)1177172953111173092Mouse
1301414Heal10_mwound healing/regeneration 10 (mouse)Not determined1177546357111546496Mouse
10045616Heal25_mwound healing/regeneration 25 (mouse)Not determined1177546357111546496Mouse
10413882Moe1_mmodifier of epilepsy 1 (mouse)1177880152111880273Mouse
1301640Lore4_mloss of righting induced by ethanol 4 (mouse)Not determined1179265183107725646Mouse
14746970Manh71_mmandible shape 71 (mouse)1179525431113525431Mouse
1300649Crhq1_mcompensatory renal hypertrophy QTL 1 (mouse)Not determined1181683655115683810Mouse
1300766Skull16_mskull morphology 16 (mouse)Not determined1181683655115683810Mouse
10412288Carg4_mCandida albicans resistance gene 4 (mouse)Not determined1181919441115919441Mouse
1301072Eae22_mexperimental allergic encephalomyelitis 22 (mouse)Not determined1182486872116486994Mouse
14747003Mancz9_mmandible centroid size 9 (mouse)1185954085119954085Mouse
15039374Adip29_madiposity 29 (mouse)1186717494120717494Mouse
15039376Bw42_mbody weight QTL 42 (mouse)1186717494120717494Mouse
15014785Mvlq1_mmacrovesicular liver lesion QTL 1 (mouse)1186717494120717494Mouse
27226789Feml16_mfemur length 16, 10 week (mouse)1187600000126900000Mouse
10044007Hbnr14_mHeligmosomoides bakeri nematode resistance 14 (mouse)Not determined1187611774121611872Mouse
11251723Ewc5_methanol withdrawal and consumption 5 (mouse)1189978425122082543Mouse
1302034Pkccl_mprotein kinase C content in lungs (mouse)Not determined1191713782122082543Mouse
1558753Ath19_matherosclerosis 19 (mouse)Not determined1191713782122082543Mouse
10045617Heal26_mwound healing/regeneration 26 (mouse)Not determined1193048547112653728Mouse
1301095El6_mepilepsy 6 (mouse)Not determined1193338357122082543Mouse
4141939Pregq2_mpregnancy QTL 2 (mouse)Not determined1194172953118131898Mouse
27226731Tibmd4_mtibia midshaft diameter 4, 10 week (mouse)1194300000119000000Mouse
4141465Dbm2_mdiabetes modifier 2 (mouse)Not determined94546357118131898Mouse
1300944Alcp20_malcohol preference locus 20 (mouse)Not determined1195513139122082543Mouse
1301958Alcp18_malcohol preference locus 18 (mouse)Not determined1195513139122082543Mouse
1300962Cd8mts4_mCD8 memory T cell subset 4 (mouse)Not determined1196246848122082543Mouse
1301535Pas5b_mpulmonary adenoma susceptibility 5b (mouse)Not determined1196285639108915558Mouse
1301057Nidd4_mnon-insulin-dependent diabetes mellitus 4 (mouse)Not determined1196919310122082543Mouse
12910539Sstapa3_msuseptibility to Staphylococcus aureus infection 3 (mouse)1197006867110713165Mouse
1301983Berr2_mberghei resistance locus 2 (mouse)Not determined1198461783122082543Mouse
10043976Obq33_mobesity QTL 33 (mouse)Not determined1198609643122082543Mouse
10044001Alcw8_malcohol withdrawal 8 (mouse)Not determined1199363361122082543Mouse
11553867Stmm5_mskin tumor modifier of MSM 5 (mouse)11100167277122082543Mouse
11341721Rvfs2_mRift Valley fever susceptibility 2 (mouse)11100363360120996339Mouse
1301012Vispl_mvisual placing (mouse)Not determined11101131764122082543Mouse
14700693Ppiq12_mprepulse inhibition QTL 12 (mouse)11101613994114581537Mouse
14700694Ppiq13_mprepulse inhibition QTL 13 (mouse)11101613994114581537Mouse
14700695Ppiq14_mprepulse inhibition QTL 14 (mouse)11101613994114581537Mouse
14700696Ppiq15_mprepulse inhibition QTL 15 (mouse)11101613994114581537Mouse
1300957Pbd1_mpeak bone density 1 (mouse)Not determined11102453297112493297Mouse
4141612Cia40_mcollagen induced arthritis 40 (mouse)Not determined11103383166115130618Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1644
Count of miRNA genes:755
Interacting mature miRNAs:946
Transcripts:ENSMUST00000001059, ENSMUST00000106799, ENSMUST00000106800, ENSMUST00000106801, ENSMUST00000131895
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence


Reference Sequences
RefSeq Acc Id: ENSMUST00000001059   ⟹   ENSMUSP00000001059
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11106,394,650 - 106,487,796 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106799   ⟹   ENSMUSP00000102411
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11106,458,556 - 106,487,803 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106800   ⟹   ENSMUSP00000102412
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11106,434,681 - 106,487,808 (-)Ensembl
RefSeq Acc Id: ENSMUST00000106801   ⟹   ENSMUSP00000102413
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11106,413,766 - 106,487,836 (-)Ensembl
RefSeq Acc Id: ENSMUST00000131895
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl11106,397,451 - 106,487,852 (-)Ensembl
RefSeq Acc Id: NM_023913   ⟹   NP_076402
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911106,288,446 - 106,378,622 (-)NCBI
GRCm3811106,397,620 - 106,487,796 (-)ENTREZGENE
MGSCv3711106,258,934 - 106,349,110 (-)RGD
Celera11118,128,975 - 118,219,164 (-)RGD
cM Map11 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036157104   ⟹   XP_036012997
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3911106,285,474 - 106,378,701 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_076402   ⟸   NM_023913
- Peptide Label: precursor
- UniProtKB: Q9EQY0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSMUSP00000001059   ⟸   ENSMUST00000001059
RefSeq Acc Id: ENSMUSP00000102413   ⟸   ENSMUST00000106801
RefSeq Acc Id: ENSMUSP00000102412   ⟸   ENSMUST00000106800
RefSeq Acc Id: ENSMUSP00000102411   ⟸   ENSMUST00000106799
RefSeq Acc Id: XP_036012997   ⟸   XM_036157104
- Peptide Label: isoform X1
Protein Domains
KEN   Protein kinase

Promoters
RGD ID:6820830
Promoter ID:MM_KWN:10250
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day4,   Brain
Transcripts:ENSMUST00000106799,   ENSMUST00000106800,   ENSMUST00000106801,   OTTMUST00000007182,   OTTMUST00000007184
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv3611106,348,879 - 106,349,379 (-)MPROMDB
RGD ID:8677092
Promoter ID:EPDNEW_M16576
Type:initiation region
Name:Ern1_1
Description:Mus musculus endoplasmic reticulum to nucleus signalling 1 ,mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm3811106,487,810 - 106,487,870EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:1930134 AgrOrtholog
Ensembl Genes ENSMUSG00000020715 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000001059 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000102411 UniProtKB/TrEMBL
  ENSMUSP00000102412 UniProtKB/TrEMBL
  ENSMUSP00000102413 UniProtKB/Swiss-Prot
Ensembl Transcript ENSMUST00000001059 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000106799 UniProtKB/TrEMBL
  ENSMUST00000106800 UniProtKB/TrEMBL
  ENSMUST00000106801 UniProtKB/Swiss-Prot
Gene3D-CATH 1.20.1440.180 UniProtKB/Swiss-Prot
  2.130.10.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro KEN_dom UniProtKB/Swiss-Prot
  KEN_sf UniProtKB/Swiss-Prot
  Kinase-like_dom_sf UniProtKB/Swiss-Prot
  PQQ_beta_propeller_repeat UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Prot_kinase_dom UniProtKB/Swiss-Prot
  Quinoprotein_ADH-like_supfam UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ser/Thr_kinase_AS UniProtKB/Swiss-Prot
  WD40/YVTN_repeat-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:78943 UniProtKB/Swiss-Prot
MGD MGI:1930134 ENTREZGENE
NCBI Gene 78943 ENTREZGENE
Pfam Pkinase UniProtKB/Swiss-Prot
  Ribonuc_2-5A UniProtKB/Swiss-Prot
PhenoGen Ern1 PhenoGen
PROSITE KEN UniProtKB/Swiss-Prot
  PROTEIN_KINASE_DOM UniProtKB/Swiss-Prot
  PROTEIN_KINASE_ST UniProtKB/Swiss-Prot
SMART PQQ UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  S_TKc UniProtKB/Swiss-Prot
Superfamily-SCOP SSF50998 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56112 UniProtKB/Swiss-Prot
UniProt B1ARJ5_MOUSE UniProtKB/TrEMBL
  B1ATQ7_MOUSE UniProtKB/TrEMBL
  ERN1_MOUSE UniProtKB/Swiss-Prot
  Q3TBZ5_MOUSE UniProtKB/TrEMBL
  Q9EQY0 ENTREZGENE
UniProt Secondary Q9D340 UniProtKB/Swiss-Prot