GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | Ern1 | increases expression | EXP | | 6480464 | CTD | Palmitic Acid results in increased expression of ERN1 mRNA; Palmitic Acid results in increased expression of ERN1 protein | PMID:36030031 | Ern1 | increases phosphorylation | EXP | | 6480464 | CTD | Palmitic Acid results in increased phosphorylation of ERN1 protein | PMID:29031535 PMID:29414781 | Ern1 | multiple interactions | EXP | | 6480464 | CTD | 4-phenylbutyric acid promotes the reaction [Palmitic Acid results in increased expression of ERN1 mRNA]; 7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]; baicalin inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]; Thapsigargin inhibits the reaction [7,14-dihydroxydocosa-4,8,10,12,16,19-hexaenoic acid inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]]; ursodoxicoltaurine inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] | PMID:29031535 PMID:29414781 PMID:36030031 | Ern1 | increases phosphorylation | ISO | ERN1 (Homo sapiens) | 6480464 | CTD | Palmitic Acid results in increased phosphorylation of ERN1 protein | PMID:32283200 | Ern1 | multiple interactions | ISO | Ern1 (Rattus norvegicus) | 6480464 | CTD | [Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 mRNA; [Palmitic Acid co-treated with Sincalide] results in increased expression of ERN1 protein; Quercetin inhibits the reaction [[Sincalide co-treated with Palmitic Acid] results in increased expression of ERN1 protein] | PMID:26873426 | Ern1 | multiple interactions | ISO | ERN1 (Homo sapiens) | 6480464 | CTD | 3-N-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate inhibits the reaction [[Palmitic Acid co-treated with Oleic Acid] results in increased expression of ERN1 mRNA]; [Palmitic Acid co-treated with Oleic Acid] results in increased expression of ERN1 mRNA; Deferoxamine promotes the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]; ferric ammonium citrate inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein]; Sirolimus inhibits the reaction [Palmitic Acid results in increased phosphorylation of ERN1 protein] | PMID:32283200 PMID:32369900 | | ||||||||||||||||||||||
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