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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558600
Species: Mus musculus
RGD Object: Gene
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Acc ID: CHEBI:16236
Term: ethanol
Definition: A primary alcohol that is ethane in which one of the hydrogens is substituted by a hydroxy group.
Chemical ID: MESH:D000431
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ern1decreases phosphorylationEXP 6480464CTDEthanol results in decreased phosphorylation of ERN1 proteinPMID:28119953
Ern1increases expressionEXP 6480464CTDEthanol results in increased expression of ERN1 mRNAPMID:30319688
Ern1increases phosphorylationEXP 6480464CTDEthanol results in increased phosphorylation of ERN1 proteinPMID:29044621
Ern1multiple interactionsEXP 6480464CTD[Bicuculline co-treated with Ethanol] results in increased phosphorylation of ERN1 protein; gamma-Aminobutyric Acid inhibits the reaction [Ethanol results in increased phosphorylation of ERN1 protein]; Muscimol inhibits the reaction [Ethanol results in increased phosphorylation of ERN1 protein]PMID:29044621
Ern1increases expressionISOERN1 (Homo sapiens)6480464CTDEthanol results in increased expression of ERN1 protein modified formPMID:24224909
Ern1multiple interactionsISOERN1 (Homo sapiens)6480464CTDresveratrol inhibits the reaction [Ethanol results in increased expression of ERN1 protein modified form]PMID:24224909
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