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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 1558600
Species: Mus musculus
RGD Object: Gene
Symbol: Ern1
Name: endoplasmic reticulum to nucleus signalling 1
Acc ID: CHEBI:42758
Term: aldehydo-D-glucose
Definition: The open chain form of D-glucose.
Chemical ID: MESH:D005947
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
Ern1increases phosphorylationISOErn1 (Rattus norvegicus)6480464CTDGlucose results in increased phosphorylation of ERN1 proteinPMID:34801538
Ern1increases phosphorylationISOERN1 (Homo sapiens)6480464CTDGlucose deficiency results in increased phosphorylation of ERN1 proteinPMID:31022492
Ern1multiple interactionsISOErn1 (Rattus norvegicus)6480464CTDChlorogenic Acid inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]; Metformin inhibits the reaction [Glucose results in increased phosphorylation of ERN1 protein]PMID:34801538
Ern1multiple interactionsISOERN1 (Homo sapiens)6480464CTD4-Quinolones analog inhibits the reaction [Glucose deficiency results in increased phosphorylation of ERN1 protein]; [Glucose co-treated with TGFB1 protein] results in increased phosphorylation of ERN1 protein; aucubin inhibits the reaction [[Glucose co-treated with TGFB1 protein] results in increased phosphorylation of ERN1 protein]PMID:31022492 PMID:35961541
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