Mavs (mitochondrial antiviral signaling protein) - Rat Genome Database

Send us a Message



Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Gene: Mavs (mitochondrial antiviral signaling protein) Mus musculus
Analyze
Symbol: Mavs
Name: mitochondrial antiviral signaling protein
RGD ID: 1614930
MGI Page MGI
Description: Enables signaling adaptor activity. Involved in several processes, including negative regulation of viral genome replication; positive regulation of myeloid dendritic cell cytokine production; and regulation of peroxisome organization. Acts upstream of or within positive regulation of cytokine production and regulation of defense response. Located in mitochondrion and peroxisome. Orthologous to human MAVS (mitochondrial antiviral signaling protein).
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; cardif; D430028G21Rik; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IP; IPS-1; MGC25836; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; RP23-387C21.3; virus-induced signaling adapter; virus-induced-signaling adapter; Visa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm39 - Mouse Genome Assembly GRCm39
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)EnsemblGRCm39 Ensembl
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBIMGSCv36mm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
antiviral innate immune response  (ISO)
cellular response to exogenous dsRNA  (ISO)
cellular response to interferon-beta  (ISO)
defense response to bacterium  (ISO)
defense response to virus  (ISO)
immune system process  (IEA)
innate immune response  (ISO)
negative regulation of viral genome replication  (IMP,ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of defense response to virus by host  (IMP,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interferon-alpha production  (IMP,ISO)
positive regulation of interferon-beta production  (IMP,ISO)
positive regulation of interleukin-6 production  (IMP,ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of IP-10 production  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of NLRP3 inflammasome complex assembly  (ISO)
positive regulation of protein homodimerization activity  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of response to cytokine stimulus  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (IMP)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
protein localization to mitochondrion  (ISO)
protein tetramerization  (ISO)
regulation of peroxisome organization  (IMP,ISO)
RIG-I signaling pathway  (IGI)
signal transduction  (IMP,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar macrophage morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal circulating interferon level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interferon-alpha secretion  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myeloid dendritic cell morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal response to infection  (IAGP)
brain inflammation  (IAGP)
CNS inflammation  (IAGP)
decreased B cell proliferation  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating interferon-alpha level  (IAGP)
decreased circulating interferon-beta level  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased susceptibility to Picornaviridae infection induced morbidity/mortality  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased dendritic cell number  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased susceptibility to Flaviviridae infection  (IAGP)
increased susceptibility to Flaviviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to Picornaviridae infection  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
myocarditis  (IAGP)
myositis  (IAGP)
neuron degeneration  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
skin inflammation  (IAGP)
stomach inflammation  (IAGP)
References

References - curated
# Reference Title Reference Citation
1. Extrinsic MAVS signaling is critical for Treg maintenance of Foxp3 expression following acute flavivirus infection. Da Costa A, etal., Sci Rep. 2017 Jan 17;7:40720. doi: 10.1038/srep40720.
2. Mitochondrial antiviral-signalling protein plays an essential role in host immunity against human metapneumovirus. Deng J, etal., J Gen Virol. 2015 Aug;96(8):2104-2113. doi: 10.1099/vir.0.000178. Epub 2015 May 7.
3. Rotavirus VP3 targets MAVS for degradation to inhibit type III interferon expression in intestinal epithelial cells. Ding S, etal., Elife. 2018 Nov 21;7. pii: 39494. doi: 10.7554/eLife.39494.
4. Transcriptomic response to Yersinia pestis: RIG-I like receptor signaling response is detrimental to the host against plague. Du Z, etal., J Genet Genomics. 2014 Jul 20;41(7):379-96. doi: 10.1016/j.jgg.2014.05.006. Epub 2014 Jun 3.
5. Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. Gupta S, etal., PLoS One. 2016 Feb 5;11(2):e0148929. doi: 10.1371/journal.pone.0148929. eCollection 2016.
6. RIG-I Signaling Is Critical for Efficient Polyfunctional T Cell Responses during Influenza Virus Infection. Kandasamy M, etal., PLoS Pathog. 2016 Jul 20;12(7):e1005754. doi: 10.1371/journal.ppat.1005754. eCollection 2016 Jul.
7. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
8. Mouse MP Annotation Import Pipeline RGD automated import pipeline
9. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
10. MAVS O-GlcNAcylation Is Essential for Host Antiviral Immunity against Lethal RNA Viruses. Song N, etal., Cell Rep. 2019 Aug 27;28(9):2386-2396.e5. doi: 10.1016/j.celrep.2019.07.085.
Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:15489334   PMID:15782199   PMID:16125763  
PMID:16141072   PMID:16141073   PMID:16153868   PMID:16177806   PMID:16713980   PMID:16785313   PMID:16858409   PMID:17452523   PMID:17709747   PMID:17723216   PMID:17878370   PMID:17942529  
PMID:17942531   PMID:17977974   PMID:18178804   PMID:18256672   PMID:18439848   PMID:18550535   PMID:18614015   PMID:18654661   PMID:18780793   PMID:18799693   PMID:18849341   PMID:18977754  
PMID:18984593   PMID:19017982   PMID:19028691   PMID:19299691   PMID:19474102   PMID:19494017   PMID:19635904   PMID:19644511   PMID:19652017   PMID:19662634   PMID:19690333   PMID:19701189  
PMID:19734229   PMID:19798431   PMID:19846534   PMID:19864603   PMID:19881509   PMID:19915568   PMID:20042593   PMID:20123960   PMID:20140195   PMID:20140199   PMID:20360967   PMID:20383149  
PMID:20424013   PMID:20451243   PMID:20592086   PMID:20661430   PMID:20686657   PMID:20855616   PMID:20861272   PMID:20975040   PMID:21130742   PMID:21184733   PMID:21187438   PMID:21248248  
PMID:21267068   PMID:21425308   PMID:21550664   PMID:21695240   PMID:21703541   PMID:21765404   PMID:21782231   PMID:21799119   PMID:21820332   PMID:21873635   PMID:21937652   PMID:21960441  
PMID:21979142   PMID:21998457   PMID:22000020   PMID:22105994   PMID:22131337   PMID:22138643   PMID:22156592   PMID:22284419   PMID:22371392   PMID:22447976   PMID:22454496   PMID:22541070  
PMID:22615570   PMID:22745163   PMID:22761364   PMID:22819843   PMID:22841161   PMID:22844514   PMID:22905357   PMID:23045604   PMID:23084425   PMID:23087404   PMID:23110254   PMID:23136205  
PMID:23300459   PMID:23314004   PMID:23408632   PMID:23499490   PMID:23544010   PMID:23582325   PMID:23596298   PMID:23601685   PMID:23754752   PMID:23784981   PMID:23903655   PMID:23918369  
PMID:23950712   PMID:23951545   PMID:23966395   PMID:24037184   PMID:24042114   PMID:24095739   PMID:24096085   PMID:24192491   PMID:24278020   PMID:24335288   PMID:24362933   PMID:24391214  
PMID:24530055   PMID:24532585   PMID:24569476   PMID:24586160   PMID:24599590   PMID:24663215   PMID:24717539   PMID:24726644   PMID:24729608   PMID:24743339   PMID:24743949   PMID:24990442  
PMID:25005357   PMID:25008915   PMID:25008929   PMID:25115498   PMID:25225670   PMID:25320282   PMID:25456137   PMID:25525875   PMID:25569216   PMID:25585356   PMID:25609814   PMID:25636800  
PMID:25642773   PMID:25692705   PMID:25717109   PMID:25847972   PMID:25897172   PMID:25981042   PMID:26079065   PMID:26114947   PMID:26183716   PMID:26232430   PMID:26246171   PMID:26292317  
PMID:26385923   PMID:26444420   PMID:26457795   PMID:26508631   PMID:26588779   PMID:26588843   PMID:26595890   PMID:26633895   PMID:26656686   PMID:26682986   PMID:26865163   PMID:26880576  
PMID:26893477   PMID:27043414   PMID:27096319   PMID:27102485   PMID:27183626   PMID:27226371   PMID:27327515   PMID:27374884   PMID:27391363   PMID:27438769   PMID:27565347   PMID:27633528  
PMID:27736772   PMID:27793594   PMID:27899525   PMID:27917412   PMID:27992402   PMID:28077630   PMID:28100675   PMID:28141795   PMID:28158275   PMID:28207838   PMID:28213497   PMID:28330900  
PMID:28400473   PMID:28410401   PMID:28424327   PMID:28527664   PMID:28539639   PMID:28564605   PMID:28594325   PMID:28630094   PMID:28634194   PMID:28729291   PMID:28822807   PMID:29106401  
PMID:29117566   PMID:29203515   PMID:29297844   PMID:29321275   PMID:29465830   PMID:29492454   PMID:29555782   PMID:29576451   PMID:29626090   PMID:29632368   PMID:29686409   PMID:29914621  
PMID:30092200   PMID:30115978   PMID:30135079   PMID:30199535   PMID:30202015   PMID:30209176   PMID:30249647   PMID:30267893   PMID:30337468   PMID:30410068   PMID:30515151   PMID:30550785  
PMID:30571996   PMID:30635240   PMID:30699352   PMID:30715798   PMID:30878284   PMID:30902577   PMID:30952814   PMID:31149635   PMID:31242236   PMID:31249303   PMID:31350848   PMID:31355779  
PMID:31358656   PMID:31366715   PMID:31390091   PMID:31395337   PMID:31416833   PMID:31428084   PMID:31511639   PMID:31562213   PMID:31604929   PMID:31681326   PMID:31685995   PMID:31792184  
PMID:31956894   PMID:31968249   PMID:31996459   PMID:32049003   PMID:32150572   PMID:32187540   PMID:32265274   PMID:32301534   PMID:32324863   PMID:32325033   PMID:32527925   PMID:32554809  
PMID:32723479   PMID:32730309   PMID:32892753   PMID:32943610   PMID:32946572   PMID:33070627   PMID:33086056   PMID:33087405   PMID:33119735   PMID:33123150   PMID:33139700   PMID:33165593  
PMID:33278357   PMID:33577398   PMID:33963333   PMID:33976210   PMID:34016972   PMID:34047074   PMID:34290407   PMID:34380029   PMID:34435375   PMID:34464586   PMID:34586646   PMID:34648591  
PMID:35108347   PMID:35168003   PMID:35545033   PMID:35584192   PMID:36045679  


Genomics

Comparative Map Data
Mavs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)EnsemblGRCm39 Ensembl
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBIMGSCv36mm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
MAVS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38203,846,834 - 3,876,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl203,846,799 - 3,876,123 (+)EnsemblGRCh38hg38GRCh38
GRCh37203,827,481 - 3,856,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,775,484 - 3,795,973 (+)NCBINCBI36Build 36hg18NCBI36
Celera203,889,325 - 3,918,630 (+)NCBICelera
Cytogenetic Map20p13NCBI
HuRef203,776,247 - 3,805,626 (+)NCBIHuRef
CHM1_1203,827,384 - 3,856,773 (+)NCBICHM1_1
T2T-CHM13v2.0203,877,778 - 3,907,055 (+)NCBIT2T-CHM13v2.0
Mavs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23118,451,650 - 118,466,094 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl3118,451,743 - 118,466,094 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx3122,346,068 - 122,360,237 (+)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.03130,945,435 - 130,959,618 (+)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.03128,602,173 - 128,616,342 (+)NCBIRnor_WKY
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Celera3117,259,863 - 117,274,017 (+)NCBICelera
Cytogenetic Map3q36NCBI
Mavs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,695,438 - 14,703,672 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,691,918 - 14,704,782 (+)NCBIChiLan1.0ChiLan1.0
MAVS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1203,659,558 - 3,702,397 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
MAVS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,510,209 - 17,529,286 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,512,761 - 17,523,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,342,451 - 17,353,500 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02417,930,606 - 17,947,974 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2417,930,603 - 17,942,617 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12417,526,451 - 17,537,501 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02417,637,457 - 17,648,500 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02417,965,346 - 17,976,396 (-)NCBIUU_Cfam_GSD_1.0
Mavs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,413,582 - 166,427,872 (-)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_00493648514,842,160 - 14,859,202 (-)EnsemblSpeTri2.0
SpeTri2.0NW_00493648514,842,778 - 14,859,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAVS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,850,900 - 31,869,188 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,850,646 - 31,869,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,193,888 - 36,210,273 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAVS
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,534,433 - 34,555,406 (+)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl234,541,229 - 34,552,823 (+)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660719,898,086 - 9,918,187 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Mavs
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046247414,939,040 - 4,954,058 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046247414,936,556 - 4,951,081 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1858
Count of miRNA genes:559
Interacting mature miRNAs:664
Transcripts:ENSMUST00000041362, ENSMUST00000110199, ENSMUST00000130597, ENSMUST00000132694
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCm39)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224224632148700377Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229307947148374934Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245347635145312647Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)261830344136841920Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265269746162518926Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284013198148522175Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284013198148667470Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285724269180896594Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294230345154241920Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297123370131123532Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297123370131123532Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297210364131210364Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297210364131210364Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100824060134824269Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2100942930134943090Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2100942930134943090Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2100942930134943090Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102630345159941920Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103095716167212356Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106233580140233729Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107255676141255676Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110489658144489807Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2110916118154354667Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111173704145173821Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111173704145173821Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111173704145173821Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111173704145173821Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111551028145551163Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111623386145623526Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112212746146213005Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112212746146213005Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112212746146213005Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114288075132714157Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115212857149212994Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115212857149212994Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116077623150077741Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116306330150306474Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2117942930174324863Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118589253160611165Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118589253160611165Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118589253160611165Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118589253160611165Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122207146142532135Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2122883015156883131Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123231973148700377Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2123937311157937424Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124441920168241920Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126041920135441920Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127664019161664118Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127664019161664118Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128173704132714157Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129341920163341920Mouse

Markers in Region
UniSTS:234535  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,247,013 - 131,247,230UniSTSGRCm38
MGSCv372131,072,749 - 131,072,966UniSTSGRCm37
Celera2132,473,378 - 132,473,595UniSTS
Cytogenetic Map2F1UniSTS
RH139303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,234,566 - 131,234,689UniSTSGRCm38
MGSCv372131,060,302 - 131,060,425UniSTSGRCm37
Celera2132,460,922 - 132,461,045UniSTS
Cytogenetic Map2F1UniSTS


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001206382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK028421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL808128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX775773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ167127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ174271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000041362   ⟹   ENSMUSP00000038339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,075,987 - 131,089,945 (+)Ensembl
GRCm38.p6 Ensembl2131,234,067 - 131,248,025 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110199   ⟹   ENSMUSP00000105828
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,076,025 - 131,089,945 (+)Ensembl
GRCm38.p6 Ensembl2131,234,105 - 131,248,025 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130597   ⟹   ENSMUSP00000138401
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,075,983 - 131,089,942 (+)Ensembl
GRCm38.p6 Ensembl2131,234,063 - 131,248,022 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132694
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm39 Ensembl2131,083,854 - 131,087,585 (+)Ensembl
GRCm38.p6 Ensembl2131,241,934 - 131,245,665 (+)Ensembl
RefSeq Acc Id: NM_001206382   ⟹   NP_001193311
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001206383   ⟹   NP_001193312
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001206385   ⟹   NP_001193314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_144888   ⟹   NP_659137
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
MGSCv372131,059,874 - 131,073,761 (+)RGD
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161358   ⟹   XP_036017251
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,445 - 131,089,945 (+)NCBI
Sequence:
RefSeq Acc Id: XM_036161359   ⟹   XP_036017252
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,992 - 131,089,945 (+)NCBI
Sequence:
Reference Sequences
RefSeq Acc Id: NP_659137   ⟸   NM_144888
- Peptide Label: isoform 1
- UniProtKB: Q8VCF0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001193311   ⟸   NM_001206382
- Peptide Label: isoform 2
- UniProtKB: Q3U5B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193314   ⟸   NM_001206385
- Peptide Label: isoform 1
- UniProtKB: Q8VCF0 (UniProtKB/Swiss-Prot),   Q3U5B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193312   ⟸   NM_001206383
- Peptide Label: isoform 2
- UniProtKB: Q3U5B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138401   ⟸   ENSMUST00000130597
RefSeq Acc Id: ENSMUSP00000105828   ⟸   ENSMUST00000110199
RefSeq Acc Id: ENSMUSP00000038339   ⟸   ENSMUST00000041362
RefSeq Acc Id: XP_036017251   ⟸   XM_036161358
- Peptide Label: isoform X1
- UniProtKB: Q3U5B1 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_036017252   ⟸   XM_036161359
- Peptide Label: isoform X1
- UniProtKB: Q3U5B1 (UniProtKB/TrEMBL)
Protein Domains
CARD

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-Q8VCF0-F1-model_v2 AlphaFold Q8VCF0 1-503 view protein structure

Promoters
RGD ID:6831805
Promoter ID:MM_KWN:31798
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000041362,   OTTMUST00000038268,   UC008MLD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362131,059,449 - 131,059,949 (+)MPROMDB
RGD ID:6832522
Promoter ID:MM_KWN:31799
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000038269
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362131,067,871 - 131,068,371 (+)MPROMDB
RGD ID:6878842
Promoter ID:EPDNEW_M2853
Type:initiation region
Name:Mavs_1
Description:Mus musculus mitochondrial antiviral signaling protein , transcriptvariant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382131,234,067 - 131,234,127EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444773 AgrOrtholog
Ensembl Genes ENSMUSG00000037523 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000038339 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105828 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000138401.2 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041362 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000110199 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000130597.8 UniProtKB/TrEMBL
Gene3D-CATH 1.10.533.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro CARD_dom UniProtKB/Swiss-Prot
  CARD_IPS1 UniProtKB/Swiss-Prot
  DEATH-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Mt_antiviral_sig_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:228607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2444773 ENTREZGENE
NCBI Gene 228607 ENTREZGENE
PANTHER PTHR21446:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD_2 UniProtKB/Swiss-Prot
PhenoGen Mavs PhenoGen
UniProt MAVS_MOUSE UniProtKB/Swiss-Prot
  Q3U5B1 ENTREZGENE, UniProtKB/TrEMBL
  Q8VCF0 ENTREZGENE
  S4R1W6_MOUSE UniProtKB/TrEMBL