Mavs (mitochondrial antiviral signaling protein) - Rat Genome Database

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Gene: Mavs (mitochondrial antiviral signaling protein) Mus musculus
Analyze
Symbol: Mavs
Name: mitochondrial antiviral signaling protein
RGD ID: 1614930
MGI Page MGI
Description: Exhibits signaling adaptor activity. Involved in several processes, including RIG-I signaling pathway; positive regulation of cytokine production; and positive regulation of defense response to virus by host. Localizes to mitochondrion and peroxisome. Orthologous to human MAVS (mitochondrial antiviral signaling protein); PARTICIPATES IN hepatitis C pathway; influenza A pathway; measles pathway; INTERACTS WITH 1,2-dimethylhydrazine; 5-aza-2'-deoxycytidine; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: CARD adapter inducing interferon beta; CARD adapter inducing interferon-beta; cardif; D430028G21Rik; IFN-beta promoter stimulator-1; interferon beta promoter stimulator protein 1; interferon-beta promoter stimulator protein 1; IP; IPS-1; MGC25836; mitochondrial anti-viral signaling protein; mitochondrial antiviral-signaling protein; RP23-387C21.3; virus-induced signaling adapter; virus-induced-signaling adapter; Visa
RGD Orthologs
Human
Rat
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)Ensembl
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBImm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations     Click to see Annotation Detail View

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
activation of innate immune response  (ISO)
cellular response to exogenous dsRNA  (ISO)
defense response to bacterium  (ISO)
defense response to virus  (ISO)
immune system process  (IEA)
innate immune response  (ISO)
negative regulation of viral genome replication  (IMP,ISO)
positive regulation of chemokine (C-C motif) ligand 5 production  (ISO)
positive regulation of defense response to virus by host  (IMP,ISO)
positive regulation of DNA-binding transcription factor activity  (ISO)
positive regulation of I-kappaB kinase/NF-kappaB signaling  (ISO)
positive regulation of interferon-alpha production  (ISO)
positive regulation of interferon-beta production  (ISO)
positive regulation of interleukin-6 production  (ISO)
positive regulation of interleukin-8 production  (ISO)
positive regulation of IP-10 production  (ISO)
positive regulation of myeloid dendritic cell cytokine production  (IMP)
positive regulation of NF-kappaB transcription factor activity  (ISO)
positive regulation of protein import into nucleus  (ISO)
positive regulation of protein phosphorylation  (ISO)
positive regulation of response to cytokine stimulus  (ISO)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of tumor necrosis factor production  (ISO)
positive regulation of type I interferon production  (IMP)
positive regulation of type I interferon-mediated signaling pathway  (ISO)
regulation of peroxisome organization  (IMP,ISO)
RIG-I signaling pathway  (IGI)
signal transduction  (IMP,ISO)

Cellular Component

Molecular Function

Molecular Pathway Annotations     Click to see Annotation Detail View
Phenotype Annotations     Click to see Annotation Detail View

Mammalian Phenotype
abnormal alveolar macrophage morphology  (IAGP)
abnormal B cell physiology  (IAGP)
abnormal circulating interferon level  (IAGP)
abnormal cytokine secretion  (IAGP)
abnormal dendritic cell physiology  (IAGP)
abnormal innate immunity  (IAGP)
abnormal interferon-alpha secretion  (IAGP)
abnormal macrophage morphology  (IAGP)
abnormal macrophage physiology  (IAGP)
abnormal myeloid dendritic cell morphology  (IAGP)
abnormal neuron physiology  (IAGP)
abnormal response to infection  (IAGP)
brain inflammation  (IAGP)
CNS inflammation  (IAGP)
decreased B cell proliferation  (IAGP)
decreased bone mineral content  (IEA)
decreased bone mineral density  (IEA)
decreased CD4-positive, alpha beta T cell number  (IAGP)
decreased CD8-positive, alpha-beta T cell number  (IAGP)
decreased circulating interferon-alpha level  (IAGP)
decreased circulating interferon-beta level  (IAGP)
decreased circulating interferon-gamma level  (IAGP)
decreased circulating interleukin-12b level  (IAGP)
decreased circulating interleukin-6 level  (IAGP)
decreased cytotoxic T cell cytolysis  (IAGP)
decreased IgG level  (IAGP)
decreased IgG1 level  (IAGP)
decreased IgG2a level  (IAGP)
decreased interferon-alpha secretion  (IAGP)
decreased interferon-beta secretion  (IAGP)
decreased interleukin-12 secretion  (IAGP)
decreased interleukin-12b secretion  (IAGP)
decreased interleukin-6 secretion  (IAGP)
decreased susceptibility to Picornaviridae infection induced morbidity/mortality  (IAGP)
decreased tumor necrosis factor secretion  (IAGP)
enlarged spleen  (IAGP)
glomerulonephritis  (IAGP)
increased circulating interferon-gamma level  (IAGP)
increased circulating interleukin-6 level  (IAGP)
increased circulating tumor necrosis factor level  (IAGP)
increased dendritic cell number  (IAGP)
increased IgG level  (IAGP)
increased IgG2a level  (IAGP)
increased IgM level  (IAGP)
increased inflammatory response  (IAGP)
increased susceptibility to Flaviviridae infection  (IAGP)
increased susceptibility to Flaviviridae infection induced morbidity/mortality  (IAGP)
increased susceptibility to Picornaviridae infection  (IAGP)
increased susceptibility to Riboviria infection  (IAGP)
increased susceptibility to Riboviria infection induced morbidity/mortality  (IAGP)
myocarditis  (IAGP)
myositis  (IAGP)
neuron degeneration  (IAGP)
perinatal lethality, complete penetrance  (IAGP)
premature death  (IAGP)
skin inflammation  (IAGP)
stomach inflammation  (IAGP)
References

Additional References at PubMed
PMID:8889548   PMID:10349636   PMID:10922068   PMID:11042159   PMID:11076861   PMID:11217851   PMID:12466851   PMID:12477932   PMID:12520002   PMID:15489334   PMID:15782199   PMID:16125763  
PMID:16141072   PMID:16141073   PMID:16153868   PMID:16177806   PMID:16713980   PMID:16785313   PMID:16858409   PMID:17452523   PMID:17709747   PMID:17723216   PMID:17878370   PMID:17942529  
PMID:17942531   PMID:17977974   PMID:18178804   PMID:18256672   PMID:18439848   PMID:18550535   PMID:18614015   PMID:18654661   PMID:18780793   PMID:18799693   PMID:18849341   PMID:18977754  
PMID:18984593   PMID:19017982   PMID:19028691   PMID:19299691   PMID:19494017   PMID:19635904   PMID:19644511   PMID:19652017   PMID:19662634   PMID:19690333   PMID:19701189   PMID:19734229  
PMID:19798431   PMID:19846534   PMID:19864603   PMID:19881509   PMID:19915568   PMID:20042593   PMID:20123960   PMID:20140195   PMID:20140199   PMID:20360967   PMID:20383149   PMID:20424013  
PMID:20451243   PMID:20661430   PMID:20686657   PMID:20855616   PMID:20861272   PMID:20975040   PMID:21130742   PMID:21184733   PMID:21187438   PMID:21248248   PMID:21267068   PMID:21425308  
PMID:21550664   PMID:21695240   PMID:21703541   PMID:21765404   PMID:21782231   PMID:21799119   PMID:21820332   PMID:21873635   PMID:21937652   PMID:21960441   PMID:21979142   PMID:21998457  
PMID:22000020   PMID:22105994   PMID:22131337   PMID:22138643   PMID:22156592   PMID:22284419   PMID:22371392   PMID:22447976   PMID:22454496   PMID:22541070   PMID:22615570   PMID:22745163  
PMID:22761364   PMID:22819843   PMID:22841161   PMID:22844514   PMID:22905357   PMID:23045604   PMID:23084425   PMID:23087404   PMID:23110254   PMID:23136205   PMID:23300459   PMID:23314004  
PMID:23408632   PMID:23499490   PMID:23544010   PMID:23582325   PMID:23596298   PMID:23601685   PMID:23754752   PMID:23784981   PMID:23903655   PMID:23918369   PMID:23950712   PMID:23951545  
PMID:24037184   PMID:24042114   PMID:24095739   PMID:24096085   PMID:24192491   PMID:24278020   PMID:24335288   PMID:24362933   PMID:24391214   PMID:24530055   PMID:24532585   PMID:24569476  
PMID:24586160   PMID:24599590   PMID:24663215   PMID:24717539   PMID:24726644   PMID:24729608   PMID:24743339   PMID:24743949   PMID:24990442   PMID:25005357   PMID:25008915   PMID:25008929  
PMID:25115498   PMID:25225670   PMID:25320282   PMID:25456137   PMID:25525875   PMID:25569216   PMID:25585356   PMID:25609814   PMID:25636800   PMID:25642773   PMID:25692705   PMID:25717109  
PMID:25847972   PMID:25897172   PMID:25981042   PMID:26079065   PMID:26114947   PMID:26183716   PMID:26232430   PMID:26246171   PMID:26292317   PMID:26385923   PMID:26444420   PMID:26457795  
PMID:26508631   PMID:26588779   PMID:26588843   PMID:26595890   PMID:26633895   PMID:26656686   PMID:26682986   PMID:26865163   PMID:26880576   PMID:26893477   PMID:27043414   PMID:27096319  
PMID:27102485   PMID:27183626   PMID:27226371   PMID:27327515   PMID:27374884   PMID:27391363   PMID:27438769   PMID:27565347   PMID:27633528   PMID:27736772   PMID:27793594   PMID:27899525  
PMID:27917412   PMID:27992402   PMID:28077630   PMID:28100675   PMID:28141795   PMID:28158275   PMID:28207838   PMID:28213497   PMID:28330900   PMID:28400473   PMID:28410401   PMID:28424327  
PMID:28527664   PMID:28539639   PMID:28564605   PMID:28594325   PMID:28630094   PMID:28634194   PMID:28729291   PMID:28822807   PMID:29106401   PMID:29117566   PMID:29203515   PMID:29297844  
PMID:29321275   PMID:29465830   PMID:29492454   PMID:29555782   PMID:29576451   PMID:29626090   PMID:29632368   PMID:29686409   PMID:29914621   PMID:30092200   PMID:30115978   PMID:30135079  
PMID:30199535   PMID:30209176   PMID:30249647   PMID:30267893   PMID:30337468   PMID:30410068   PMID:30515151   PMID:30550785   PMID:30571996   PMID:30635240   PMID:30699352   PMID:30715798  
PMID:30878284   PMID:30902577   PMID:30952814   PMID:31149635   PMID:31242236   PMID:31249303   PMID:31350848   PMID:31355779   PMID:31358656   PMID:31390091   PMID:31395337   PMID:31428084  
PMID:31604929   PMID:31681326   PMID:31685995   PMID:31792184   PMID:31956894   PMID:31968249   PMID:31996459   PMID:32049003   PMID:32150572   PMID:32187540   PMID:32265274   PMID:32301534  
PMID:32325033   PMID:32527925   PMID:32730309   PMID:32892753   PMID:33086056   PMID:33087405   PMID:33119735   PMID:33139700   PMID:33165593  


Genomics

Comparative Map Data
Mavs
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm392131,075,445 - 131,089,945 (+)NCBIGRCm39mm39
GRCm39 Ensembl2131,075,983 - 131,089,945 (+)Ensembl
GRCm382131,234,063 - 131,248,025 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl2131,234,063 - 131,248,025 (+)EnsemblGRCm38mm10GRCm38
MGSCv372131,059,874 - 131,073,761 (+)NCBIGRCm37mm9NCBIm37
MGSCv362130,925,579 - 130,939,466 (+)NCBImm8
Celera2132,460,494 - 132,474,382 (+)NCBICelera
Cytogenetic Map2F1NCBI
MAVS
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl203,846,799 - 3,876,123 (+)EnsemblGRCh38hg38GRCh38
GRCh38203,846,834 - 3,876,118 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37203,827,481 - 3,856,765 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36203,775,484 - 3,795,973 (+)NCBINCBI36hg18NCBI36
Celera203,889,325 - 3,918,630 (+)NCBI
Cytogenetic Map20p13NCBI
HuRef203,776,247 - 3,805,626 (+)NCBIHuRef
CHM1_1203,827,384 - 3,856,773 (+)NCBICHM1_1
Mavs
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.23118,451,650 - 118,466,094 (+)NCBI
Rnor_6.0 Ensembl3123,776,181 - 123,790,567 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_6.03123,776,147 - 123,790,572 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_5.03130,273,531 - 130,287,792 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.43118,938,433 - 118,953,081 (+)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.13118,844,005 - 118,858,653 (+)NCBI
Celera3117,259,863 - 117,274,017 (+)NCBICelera
Cytogenetic Map3q36NCBI
Mavs
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_00495541514,695,438 - 14,703,672 (+)EnsemblChiLan1.0
ChiLan1.0NW_00495541514,691,918 - 14,704,782 (+)NCBIChiLan1.0ChiLan1.0
MAVS
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.1203,659,558 - 3,702,397 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl203,659,559 - 3,701,089 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v0203,885,044 - 3,903,554 (+)NCBIMhudiblu_PPA_v0panPan3
MAVS
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12417,510,209 - 17,529,286 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2417,512,761 - 17,523,807 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2417,342,451 - 17,353,500 (-)NCBI
ROS_Cfam_1.02417,930,606 - 17,947,974 (-)NCBI
UMICH_Zoey_3.12417,526,451 - 17,537,501 (-)NCBI
UNSW_CanFamBas_1.02417,637,457 - 17,648,500 (-)NCBI
UU_Cfam_GSD_1.02417,965,346 - 17,976,396 (-)NCBI
Mavs
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024408640166,413,582 - 166,427,872 (-)NCBI
SpeTri2.0NW_00493648514,842,778 - 14,859,163 (-)NCBISpeTri2.0SpeTri2.0SpeTri2.0
MAVS
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl1731,850,155 - 31,869,187 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.11731,850,646 - 31,869,273 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.21736,193,888 - 36,210,273 (-)NCBISscrofa10.2Sscrofa10.2susScr3
MAVS
(Chlorocebus sabaeus - African green monkey)
Vervet AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1234,534,433 - 34,555,406 (+)NCBI
ChlSab1.1 Ensembl234,541,229 - 34,552,823 (+)Ensembl
Mavs
(Heterocephalus glaber - naked mole-rat)
Molerat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla 1.0NW_0046247414,936,556 - 4,951,081 (+)NCBI

Position Markers
UniSTS:234535  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,247,013 - 131,247,230UniSTSGRCm38
MGSCv372131,072,749 - 131,072,966UniSTSGRCm37
Celera2132,473,378 - 132,473,595UniSTS
Cytogenetic Map2F1UniSTS
RH139303  
Mouse AssemblyChrPosition (strand)SourceJBrowse
GRCm382131,234,566 - 131,234,689UniSTSGRCm38
MGSCv372131,060,302 - 131,060,425UniSTSGRCm37
Celera2132,460,922 - 132,461,045UniSTS
Cytogenetic Map2F1UniSTS


QTLs in Region (GRCm38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1302174Dssc2_mdextran sodium sulfate induced colitis QTL2 (mouse)Not determined224334620148858457Mouse
4141854T2dm2sa_mtype 2 diabetes mellitus 2 in SMXA RI mice (mouse)Not determined229417935148533014Mouse
1301344Lith1_mlithogenic gene 1 (mouse)Not determined245457623145470727Mouse
13824983Vclq1_mcurvilinear velocity QTL 1 (mouse)262000000137000000Mouse
5491197Mobq5_mmultigenic obesity QTL 5 (mouse)Not determined265439402162677006Mouse
4141155Plast2b_mplasma plant sterol 2b (mouse)Not determined284182854148680255Mouse
10412082Hylaq1_mHyperlocomotor activity related QTL 1 (mouse)Not determined284182854148825550Mouse
5491196Mobq6_mmultigenic obesity QTL 6 (mouse)Not determined285893925181254801Mouse
27226761Feml18_mfemur length 18, 16 week (mouse)294400000154400000Mouse
11049568Lmr28c_mleishmaniasis resistance 28c (mouse)297292889131293051Mouse
11049569Lmr28d_mleishmaniasis resistance 28d (mouse)297292889131293051Mouse
12904935Edlmmq2_mextensor digitorum longus muscle mass QTL 2 (mouse)297379883131379883Mouse
12904954Gmmq2_mgastrocnemius muscle mass QTL 2 (mouse)297379883131379883Mouse
4141802Ignpq1_mIgA nephropathy QTL 1 (mouse)Not determined2100993579134993788Mouse
1301330Tbbmd2_mtotal body bone mineral density 2 (mouse)Not determined2101112449135112609Mouse
1302203Gvhd3_mgraft-versus host disease 3 (mouse)Not determined2101112449135112609Mouse
1302071Fembrs1_mfemur breaking strength 1 (mouse)Not determined2101112449135112609Mouse
27226788Feml13_mfemur length 13, 10 week (mouse)2102800000160100000Mouse
11038702Ltpr2_mLeishmania tropica response 2 (mouse)2103265371167370436Mouse
1301825Pbrgcsf1_mperipheral blood stem cell response to granulocyte colony stimulating factor 1 (mouse)Not determined2106391660140391809Mouse
10043875Bw25_mbody weight QTL 25 (mouse)Not determined2107413756141413756Mouse
1301087Bbaa15_mB.burgdorferi-associated arthritis 15 (mouse)Not determined2110647738144647887Mouse
10045885Cplaq15_mcircadian period of locomotor activity 15 (mouse)Not determined2111085773154512747Mouse
1300793Pcfm2_mperiosteal circumference and femur length 2 (mouse)Not determined2111331784145331901Mouse
1301755Hrq1_mheart rate quantitative locus 1 (mouse)Not determined2111331784145331901Mouse
1301905Lgth2_mbody length 2 (mouse)Not determined2111331784145331901Mouse
1558990Skmw9_mskeletal muscle weight 9 (mouse)Not determined2111331784145331901Mouse
1301201Chab1_mcholesterol absorption 1 (mouse)Not determined2111709108145709243Mouse
1302033Nsv1_mNeuroadapted Sindbis viral RNA level 1 (mouse)Not determined2111781466145781606Mouse
11038699Ltpr2b_mLeishmania tropica response 2b (mouse)2112370826146371085Mouse
11038700Ltpr2a_mLeishmania tropica response 2a (mouse)2112370826146371085Mouse
11039520Ltpr2h_mLeishmania tropica response 2h (mouse)2112370826146371085Mouse
1301029T2dm3_mtype 2 diabetes mellitus 3 (mouse)Not determined2114457594132872237Mouse
11038696Ltpr2f_mLeishmania tropica response 2f (mouse)2115370937149371074Mouse
11039521Ltpr2g_mLeishmania tropica response 2g (mouse)2115370937149371074Mouse
1301295Prdt1_mprion disease incubation time 1 (mouse)Not determined2116235703150235821Mouse
1558881Ses7_msalmonella enteritidis susceptibility 7 (mouse)Not determined2116464410150464554Mouse
1301618Bglu1_mblood glucose level 1 (mouse)Not determined2118112449174483070Mouse
12910795Pwbwq5_mpost-weaning body weight QTL 5 (mouse)2118758772160769245Mouse
12910799Pwgrq2_mpre-weaning growth rate QTL 2 (mouse)2118758772160769245Mouse
12910812Pwgrq1_mpre-weaning growth rate QTL 1 (mouse)2118758772160769245Mouse
12910814Pwbwq1_mpre-weaning body weight QTL 1 (mouse)2118758772160769245Mouse
1300712El2_mepilepsy 2 (mouse)Not determined2122376665142690215Mouse
1301294Hrtfm5_mheart failure modifier 5 (mouse)Not determined2123041095157041211Mouse
1301066Otx2m2_morthodenticle homolog 2 (Drosophila) modifier 2 (mouse)Not determined2123390053148858457Mouse
1301822Pgia2_mproteoglycan induced arthritis 2 (mouse)Not determined2124095391158095504Mouse
27226749Femd10_mfemur midshaft diameter 10, 16 week (mouse)2124600000168400000Mouse
13506763Tbvq1_mtrabecular bone volume QTL 1 (mouse)2126200000135600000Mouse
1301031Bdln3_mbody length 3 (mouse)Not determined2127822099161822198Mouse
1302143Bwq5_mbody weight (mouse)Not determined2127822099161822198Mouse
1558989Gnf4_mgrowth and fatness 4 (mouse)Not determined2128331784132872237Mouse
12880427V25Dq3_mvitamin D inactive form serum level QTL 3 (mouse)2129500000163500000Mouse

miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:1858
Count of miRNA genes:559
Interacting mature miRNAs:664
Transcripts:ENSMUST00000041362, ENSMUST00000110199, ENSMUST00000130597, ENSMUST00000132694
Prediction methods:Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


Expression


Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001206382 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206383 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_001206385 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_144888 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161358 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_036161359 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AK028421 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK028708 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK085038 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK153748 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK161823 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK177575 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK178965 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK181725 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK189538 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK193001 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK195306 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AK203321 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AL808128 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  AX775773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC020006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC025825 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC031352 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC037391 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH466519 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ167127 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  DQ174271 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSMUST00000041362   ⟹   ENSMUSP00000038339
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2131,234,067 - 131,248,025 (+)Ensembl
RefSeq Acc Id: ENSMUST00000110199   ⟹   ENSMUSP00000105828
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2131,234,105 - 131,248,025 (+)Ensembl
RefSeq Acc Id: ENSMUST00000130597   ⟹   ENSMUSP00000138401
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2131,234,063 - 131,248,022 (+)Ensembl
RefSeq Acc Id: ENSMUST00000132694
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm38.p6 Ensembl2131,241,934 - 131,245,665 (+)Ensembl
RefSeq Acc Id: NM_001206382   ⟹   NP_001193311
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001206383   ⟹   NP_001193312
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_001206385   ⟹   NP_001193314
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: NM_144888   ⟹   NP_659137
RefSeq Status: VALIDATED
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,983 - 131,089,945 (+)NCBI
GRCm382131,234,063 - 131,248,025 (+)ENTREZGENE
MGSCv372131,059,874 - 131,073,761 (+)RGD
Celera2132,460,419 - 132,474,382 (+)ENTREZGENE
cM Map2 ENTREZGENE
Sequence:
RefSeq Acc Id: XM_036161358   ⟹   XP_036017251
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,445 - 131,089,945 (+)NCBI
RefSeq Acc Id: XM_036161359   ⟹   XP_036017252
RefSeq Status:
Type: CODING
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm392131,075,992 - 131,089,945 (+)NCBI
Reference Sequences
RefSeq Acc Id: NP_659137   ⟸   NM_144888
- Peptide Label: isoform 1
- UniProtKB: Q8VCF0 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: NP_001193311   ⟸   NM_001206382
- Peptide Label: isoform 2
- UniProtKB: Q3U5B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193314   ⟸   NM_001206385
- Peptide Label: isoform 1
- UniProtKB: Q8VCF0 (UniProtKB/Swiss-Prot),   Q3U5B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_001193312   ⟸   NM_001206383
- Peptide Label: isoform 2
- UniProtKB: Q3U5B1 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: ENSMUSP00000138401   ⟸   ENSMUST00000130597
RefSeq Acc Id: ENSMUSP00000105828   ⟸   ENSMUST00000110199
RefSeq Acc Id: ENSMUSP00000038339   ⟸   ENSMUST00000041362
RefSeq Acc Id: XP_036017251   ⟸   XM_036161358
- Peptide Label: isoform X1
RefSeq Acc Id: XP_036017252   ⟸   XM_036161359
- Peptide Label: isoform X1
Protein Domains
CARD

Promoters
RGD ID:6831805
Promoter ID:MM_KWN:31798
Type:CpG-Island
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:3T3L1_Day0,   3T3L1_Day1,   3T3L1_Day2,   3T3L1_Day3,   3T3L1_Day4,   3T3L1_Day6,   BoneMarrow_0Hour,   BoneMarrow_2Hour,   BoneMarrow_4Hour,   Brain,   ES_Cell,   Kidney,   Liver,   Lung,   MEF_B4,   MEF_B6,   Spleen
Transcripts:ENSMUST00000041362,   OTTMUST00000038268,   UC008MLD.1
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362131,059,449 - 131,059,949 (+)MPROMDB
RGD ID:6832522
Promoter ID:MM_KWN:31799
Type:Non-CpG
SO ACC ID:SO:0000170
Source:MPROMDB
Tissues & Cell Lines:Kidney
Transcripts:OTTMUST00000038269
Position:
Mouse AssemblyChrPosition (strand)Source
MGSCv362131,067,871 - 131,068,371 (+)MPROMDB
RGD ID:6878842
Promoter ID:EPDNEW_M2853
Type:initiation region
Name:Mavs_1
Description:Mus musculus mitochondrial antiviral signaling protein , transcriptvariant 4, mRNA.
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Mouse AssemblyChrPosition (strand)Source
GRCm382131,234,067 - 131,234,127EPDNEW

Additional Information

Database Acc Id Source(s)
AGR Gene MGI:2444773 AgrOrtholog
Ensembl Genes ENSMUSG00000037523 Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Ensembl Protein ENSMUSP00000038339 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000105828 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUSP00000138401 UniProtKB/TrEMBL
Ensembl Transcript ENSMUST00000041362 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000110199 ENTREZGENE, UniProtKB/Swiss-Prot
  ENSMUST00000130597 UniProtKB/TrEMBL
InterPro CARD_dom UniProtKB/Swiss-Prot
  CARD_IPS1 UniProtKB/Swiss-Prot
  Mt_antiviral_sig_pro UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report mmu:228607 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
MGD MGI:2444773 ENTREZGENE
NCBI Gene 228607 ENTREZGENE
PANTHER PTHR21446:SF6 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Pfam CARD_2 UniProtKB/Swiss-Prot
PhenoGen Mavs PhenoGen
UniProt MAVS_MOUSE UniProtKB/Swiss-Prot
  Q3U5B1 ENTREZGENE, UniProtKB/TrEMBL
  Q8VCF0 ENTREZGENE
  S4R1W6_MOUSE UniProtKB/TrEMBL