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Gene: Cd74 (CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)) Mus musculus
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Symbol: Cd74
Name: CD74 antigen (invariant polypeptide of major histocompatibility complex, class II antigen-associated)
Description: Exhibits MHC class II protein binding activity; cytokine receptor activity; and nitric-oxide synthase binding activity. Contributes to cytokine binding activity. Involved in several processes, including regulation of T cell differentiation; regulation of signal transduction; and thymic T cell selection. Localizes to several cellular components, including the NOS2-CD74 complex; macrophage migration inhibitory factor receptor complex; and multivesicular body. Colocalizes with the MHC class II protein complex. Is expressed in thymus primordium. Orthologous to human CD74 (CD74 molecule); PARTICIPATES IN antigen processing and presentation pathway; tuberculosis pathway; INTERACTS WITH 1,1-dichloroethene; 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: class II-associated invariant chain peptide; CLIP; DHLAG; dinucleotide microsatellite; H-2 class II histocompatibility antigen gamma chain; histocompatibility: class II antigens, gamma chain of; HLA-DR-GAMMA; HLADG; ia antigen-associated invariant chain; Ia-associated invariant chain; Ia-GAMMA; Ii; invariant polypeptide of major histocompatibility complex, class II antigen-associated; MHC class II-associated invariant chain
Orthologs:
Homo sapiens (human) : CD74 (CD74 molecule)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cd74 (CD74 molecule)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cd74 (CD74 molecule)
Pan paniscus (bonobo/pygmy chimpanzee) : CD74 (CD74 molecule)
Canis lupus familiaris (dog) : CD74 (CD74 molecule)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cd74 (CD74 molecule)
Sus scrofa (pig) : CD74 (CD74 molecule)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381860,803,849 - 60,812,652 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371860,963,503 - 60,972,306 (+)NCBIGRCm37mm9NCBIm37
MGSCv361860,929,247 - 60,938,021 (+)NCBImm8
Celera1862,088,874 - 62,098,436 (+)NCBICelera
Cytogenetic Map18 E1NCBI
cM Map1834.41NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Cd74
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 1553657
Created: 2005-09-30
Species: Mus musculus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.