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Gene: Glb1 (galactosidase, beta 1) Mus musculus
Symbol: Glb1
Name: galactosidase, beta 1
Description: This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a lysosomal enzyme that catalyzes the hydrolysis of terminal beta-D-galactose residues in various substrates like lactose, ganglioside GM1 and other glycoproteins. Mutations in the human gene are associated with GM1-gangliosidosis and Morquio B syndrome. Disruption of the mouse gene mirrors the symptoms of human gangliosidosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acid beta-galactosidase; AW125515; beta-galactosidase; beta-galactosidase complex; beta-galactosidase electrophoretic; beta-galactosidase systemic regulator; beta-galactosidase temporal; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; lactase
Homo sapiens (human) : GLB1 (galactosidase beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glb1 (galactosidase, beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glb1 (galactosidase beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GLB1 (galactosidase beta 1)
Canis lupus familiaris (dog) : GLB1 (galactosidase beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glb1 (galactosidase beta 1)
Sus scrofa (pig) : GLB1 (galactosidase beta 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm389114,401,078 - 114,474,379 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379114,310,237 - 114,383,495 (+)NCBIGRCm37mm9NCBIm37
MGSCv369114,249,817 - 114,323,075 (+)NCBImm8
Celera9114,872,817 - 114,948,662 (+)NCBICelera
Cytogenetic Map9 F3NCBI
cM Map964.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status


Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Glb1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10651
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.