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Gene: Glb1 (galactosidase, beta 1) Mus musculus
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Symbol: Glb1
Name: galactosidase, beta 1
Description: This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a lysosomal enzyme that catalyzes the hydrolysis of terminal beta-D-galactose residues in various substrates like lactose, ganglioside GM1 and other glycoproteins. Mutations in the human gene are associated with GM1-gangliosidosis and Morquio B syndrome. Disruption of the mouse gene mirrors the symptoms of human gangliosidosis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: acid beta-galactosidase; AW125515; beta-galactosidase; beta-galactosidase complex; beta-galactosidase electrophoretic; beta-galactosidase systemic regulator; beta-galactosidase temporal; Bge; Bgl; Bgl-e; Bgl-s; Bgl-t; Bgs; Bgt; C130097A14Rik; lactase
Orthologs:
Homo sapiens (human) : GLB1 (galactosidase beta 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Glb1 (galactosidase, beta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Glb1 (galactosidase beta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : GLB1 (galactosidase beta 1)
Canis lupus familiaris (dog) : GLB1 (galactosidase beta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Glb1 (galactosidase beta 1)
Sus scrofa (pig) : GLB1 (galactosidase beta 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm389114,401,078 - 114,474,379 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv379114,310,237 - 114,383,495 (+)NCBIGRCm37mm9NCBIm37
MGSCv369114,249,817 - 114,323,075 (+)NCBImm8
Celera9114,872,817 - 114,948,662 (+)NCBICelera
Cytogenetic Map9 F3NCBI
cM Map964.4NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Glb1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 10651
Created: 2000-05-25
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.