Advanced Search (OLGA)

Gene: Sirt3 (sirtuin 3) Mus musculus

Analyze

Symbol:

Sirt3

Name:

sirtuin 3

RGD ID:

1318107

MGI Page

MGI

Description:

Enables NAD-dependent protein lysine deacetylase activity; protein lysine deacetylase activity; and sequence-specific DNA binding activity. Involved in peptidyl-lysine deacetylation; positive regulation of ceramide biosynthetic process; and positive regulation of mitochondrial transcription. Acts upstream of or within negative regulation of peptidyl-lysine acetylation; protein deacetylation; and tricarboxylic acid cycle. Located in mitochondrial inner membrane and mitochondrial matrix. Part of protein-containing complex. Is expressed in several structures, including brain; branchial arch; endocrine gland; genitourinary system; and liver and biliary system. Used to study abdominal obesity-metabolic syndrome. Orthologous to human SIRT3 (sirtuin 3).

Type:

protein-coding

RefSeq Status:

VALIDATED

Previously known as:

2310003L23Rik; AI848213; mitochondrial protein lysine deacetylase; mSIR2L3; NAD-dependent deacetylase sirtuin-3; NAD-dependent protein deacetylase sirtuin-3; NAD-dependent protein delactylase sirtuin-3; regulatory protein SIR2 homolog 3; Si; silent mating type information regulation 2, (S.cerevisiae, homolog)-like 3; SIR2-like protein 3; Sir2l3; SIRT3L mitochondrial

RGD Orthologs

Alliance Orthologs

More Info

more info ...

More Info

Species	Gene symbol and name	Data Source	Assertion derived from	less info ...
Orthologs ¹				less info ...
Homo sapiens (human):	SIRT3 (sirtuin 3)	HGNC	EggNOG, Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Rattus norvegicus (Norway rat):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chinchilla lanigera (long-tailed chinchilla):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Pan paniscus (bonobo/pygmy chimpanzee):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Canis lupus familiaris (dog):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Sus scrofa (pig):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Chlorocebus sabaeus (green monkey):	SIRT3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Heterocephalus glaber (naked mole-rat):	Sirt3 (sirtuin 3)	Transitive Ortholog Pipeline	Transitive Ortholog Pipeline
Alliance orthologs ³
Rattus norvegicus (Norway rat):	Sirt3 (sirtuin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Homo sapiens (human):	SIRT3 (sirtuin 3)	Alliance	DIOPT (Ensembl Compara\|HGNC\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)
Danio rerio (zebrafish):	sirt3 (sirtuin 3)	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid\|ZFIN)
Saccharomyces cerevisiae (baker's yeast):	HST2	Alliance	DIOPT (InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|SonicParanoid)
Xenopus tropicalis (tropical clawed frog):	sirt3.1	Alliance	DIOPT (Ensembl Compara\|Hieranoid\|InParanoid\|OMA\|OrthoFinder\|OrthoInspector\|PANTHER\|PhylomeDB\|SonicParanoid)

Latest Assembly:

GRCm39 - Mouse Genome Assembly GRCm39

Position:

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,443,576 - 140,462,222 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	140,443,579 - 140,462,222 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	140,863,663 - 140,882,309 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,863,666 - 140,882,309 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,049,562 - 148,068,208 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	140,714,990 - 140,733,629 (-)	NCBI		MGSCv36	mm8
Celera	7	140,655,950 - 140,674,596 (-)	NCBI		Celera
Cytogenetic Map	7	F4- F5	NCBI
cM Map	7	86.07	NCBI

JBrowse:

View Region in Genome Browser (JBrowse)

Model

Annotation Click to see Annotation Detail View

RGD Manual Disease Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	Alzheimer's disease		IEP		9586045	mRNA:increased expression:brain	RGD
Sirt3	Mouse	congestive heart failure		ISO	RGD:1308374	9586040	protein:decreased expression:heart left ventricle	RGD
Sirt3	Mouse	metabolic dysfunction-associated steatotic liver disease	treatment	ISO	RGD:1308374	9586049	associated with Obesity	RGD
Sirt3	Mouse	myocardial infarction	treatment	ISO	RGD:1308374	9586050		RGD
Sirt3	Mouse	obesity		ISO	RGD:1308374	9586047		RGD
Sirt3	Mouse	prediabetes syndrome		ISO	RGD:1308374	9586046	protein:decreased expression:testis	RGD
Sirt3	Mouse	Presbycusis		ISO	RGD:1308374	8158103	protein:decreased expression:auditory cortex:	RGD
Sirt3	Mouse	type 2 diabetes mellitus		ISO	RGD:1318106	9586042	mRNA:decreased expression:pancreatic islet	RGD

Imported Disease Annotations - ClinVar

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	Beckwith-Wiedemann syndrome		ISO	RGD:1318106	8554872	ClinVar Annotator: match by term: Beckwith-Wiedemann syndrome	ClinVar	PMID:21910219\|PMID:25427884\|PMID:28492532
Sirt3	Mouse	immunodeficiency 39		ISO	RGD:1318106	8554872	ClinVar Annotator: match by term: Immunodeficiency 39	ClinVar	PMID:28492532

Imported Disease Annotations - CTD

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	drug-induced hearing loss		ISO	RGD:1318106	11554173	CTD Direct Evidence: therapeutic	CTD	PMID:36800006
Sirt3	Mouse	gestational diabetes		ISO	RGD:1318106	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23956348
Sirt3	Mouse	Mouth Neoplasms		ISO	RGD:1318106	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21472714
Sirt3	Mouse	obesity		ISO	RGD:1318106	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:23956348
Sirt3	Mouse	squamous cell carcinoma		ISO	RGD:1318106	11554173	CTD Direct Evidence: marker/mechanism	CTD	PMID:21472714

Imported Disease Annotations - MGI

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	abdominal obesity-metabolic syndrome		IAGP		13592920		MouseDO

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	(+)-schisandrin B	multiple interactions	ISO	RGD:1308374	6480464	schizandrin B inhibits the reaction [Carbon Tetrachloride results in decreased expression of SIRT3 mRNA]	CTD	PMID:31150632
Sirt3	Mouse	(-)-epigallocatechin 3-gallate	decreases expression	EXP		6480464	epigallocatechin gallate results in decreased expression of SIRT3 mRNA; epigallocatechin gallate results in decreased expression more ...	CTD	PMID:29175576
Sirt3	Mouse	(1->4)-beta-D-glucan	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SIRT3 mRNA	CTD	PMID:36331819
Sirt3	Mouse	(R)-carnitine	multiple interactions	EXP		6480464	Carnitine inhibits the reaction [Cyclophosphamide results in increased expression of SIRT3 mRNA]	CTD	PMID:37863343
Sirt3	Mouse	(R)-lipoic acid	increases expression	ISO	RGD:1308374	6480464	Thioctic Acid results in increased expression of SIRT3 protein	CTD	PMID:22327056
Sirt3	Mouse	(R)-lipoic acid	multiple interactions	EXP		6480464	Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]	CTD	PMID:37739047
Sirt3	Mouse	(R)-lipoic acid	multiple interactions	ISO	RGD:1308374	6480464	[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results more ...	CTD	PMID:22327056
Sirt3	Mouse	1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane	decreases expression	EXP		6480464	2,2-bis(4-hydroxyphenyl)-1,1,1-trichloroethane results in decreased expression of SIRT3 mRNA	CTD	PMID:25575267
Sirt3	Mouse	1,1-dichloroethene	decreases expression	EXP		6480464	vinylidene chloride results in decreased expression of SIRT3 mRNA	CTD	PMID:26682919
Sirt3	Mouse	1,2-dimethylhydrazine	multiple interactions	EXP		6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIRT3 mRNA	CTD	PMID:22206623
Sirt3	Mouse	1,2-dimethylhydrazine	decreases expression	EXP		6480464	1,2-Dimethylhydrazine results in decreased expression of SIRT3 mRNA	CTD	PMID:22206623
Sirt3	Mouse	1,3,7,9-tetramethyluric acid	multiple interactions	ISO	RGD:1308374	6480464	1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results more ...	CTD	PMID:35872049
Sirt3	Mouse	17alpha-ethynylestradiol	decreases expression	ISO	RGD:1308374	6480464	Ethinyl Estradiol results in decreased expression of SIRT3 mRNA	CTD	PMID:17557909
Sirt3	Mouse	17alpha-ethynylestradiol	multiple interactions	EXP		6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIRT3 mRNA	CTD	PMID:17942748
Sirt3	Mouse	17beta-estradiol	decreases expression	EXP		6480464	Estradiol results in decreased expression of SIRT3 mRNA	CTD	PMID:25575267\|PMID:39298647
Sirt3	Mouse	17beta-estradiol	decreases expression	ISO	RGD:1308374	6480464	Estradiol results in decreased expression of SIRT3 mRNA	CTD	PMID:32145629
Sirt3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	multiple interactions	EXP		6480464	[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of SIRT3 mRNA	CTD	PMID:17942748
Sirt3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1308374	6480464	Tetrachlorodibenzodioxin results in increased expression of SIRT3 mRNA	CTD	PMID:33387578
Sirt3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	increases expression	ISO	RGD:1318106	6480464	Tetrachlorodibenzodioxin results in increased expression of SIRT3 mRNA	CTD	PMID:28011154
Sirt3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	ISO	RGD:1308374	6480464	Tetrachlorodibenzodioxin results in decreased expression of SIRT3 mRNA	CTD	PMID:21724226\|PMID:32109520
Sirt3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	affects expression	EXP		6480464	Tetrachlorodibenzodioxin affects the expression of SIRT3 mRNA	CTD	PMID:21570461
Sirt3	Mouse	2,3,7,8-tetrachlorodibenzodioxine	decreases expression	EXP		6480464	Tetrachlorodibenzodioxin results in decreased expression of SIRT3 mRNA	CTD	PMID:19770486
Sirt3	Mouse	2,4-dinitrotoluene	affects expression	ISO	RGD:1308374	6480464	2,4-dinitrotoluene affects the expression of SIRT3 mRNA	CTD	PMID:21346803
Sirt3	Mouse	3,5-diethoxycarbonyl-1,4-dihydrocollidine	decreases expression	EXP		6480464	Dicarbethoxydihydrocollidine results in decreased expression of SIRT3 mRNA	CTD	PMID:18098314
Sirt3	Mouse	3-chloropropane-1,2-diol	increases expression	EXP		6480464	alpha-Chlorohydrin results in increased expression of SIRT3 mRNA	CTD	PMID:33913518
Sirt3	Mouse	4,4'-sulfonyldiphenol	decreases expression	EXP		6480464	bisphenol S results in decreased expression of SIRT3 mRNA	CTD	PMID:39298647
Sirt3	Mouse	4-hydroxynon-2-enal	multiple interactions	ISO	RGD:1318106	6480464	4-hydroxy-2-nonenal binds to and results in decreased activity of SIRT3 protein	CTD	PMID:21449565
Sirt3	Mouse	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	multiple interactions	ISO	RGD:1308374	6480464	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein]	CTD	PMID:31981641
Sirt3	Mouse	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide	decreases activity	ISO	RGD:1318106	6480464	6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide results in decreased activity of SIRT3 protein	CTD	PMID:26518726
Sirt3	Mouse	6-propyl-2-thiouracil	decreases expression	ISO	RGD:1308374	6480464	Propylthiouracil results in decreased expression of SIRT3 mRNA	CTD	PMID:30047161
Sirt3	Mouse	8-Br-cAMP	increases expression	EXP		6480464	8-Bromo Cyclic Adenosine Monophosphate results in increased expression of SIRT3 mRNA	CTD	PMID:23166782
Sirt3	Mouse	ADP	decreases abundance	EXP		6480464	SIRT3 protein results in decreased abundance of Adenosine Diphosphate	CTD	PMID:23166782
Sirt3	Mouse	aldehydo-D-glucose	multiple interactions	EXP		6480464	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased more ...	CTD	PMID:25979314
Sirt3	Mouse	aldehydo-D-glucose	decreases expression	ISO	RGD:1318106	6480464	Glucose results in decreased expression of SIRT3 protein	CTD	PMID:37417536
Sirt3	Mouse	aldehydo-D-glucose	decreases expression	ISO	RGD:1308374	6480464	Glucose results in decreased expression of SIRT3 mRNA; Glucose results in decreased expression of SIRT3 more ...	CTD	PMID:37944786
Sirt3	Mouse	aldehydo-D-glucose	multiple interactions	ISO	RGD:1308374	6480464	formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the more ...	CTD	PMID:37944786
Sirt3	Mouse	aldehydo-D-glucose	multiple interactions	ISO	RGD:1318106	6480464	polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]; SIRT3 more ...	CTD	PMID:23494737\|PMID:37417536
Sirt3	Mouse	aldehydo-D-glucose	increases expression	ISO	RGD:1318106	6480464	Glucose deficiency results in increased expression of SIRT3 protein	CTD	PMID:23494737
Sirt3	Mouse	alpha-mangostin	multiple interactions	ISO	RGD:1318106	6480464	SIRT3 protein affects the reaction [mangostin results in decreased expression of ACTA2 protein]; SIRT3 protein more ...	CTD	PMID:30502394
Sirt3	Mouse	alpha-mangostin	multiple interactions	EXP		6480464	[mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion more ...	CTD	PMID:30502394
Sirt3	Mouse	alpha-mangostin	increases expression	ISO	RGD:1318106	6480464	mangostin results in increased expression of SIRT3 protein	CTD	PMID:30502394
Sirt3	Mouse	amitrole	decreases expression	ISO	RGD:1308374	6480464	Amitrole results in decreased expression of SIRT3 mRNA	CTD	PMID:30047161
Sirt3	Mouse	antimycin A	multiple interactions	ISO	RGD:1318106	6480464	Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SIRT3 mRNA]	CTD	PMID:35430258
Sirt3	Mouse	antimycin A	increases expression	ISO	RGD:1318106	6480464	Antimycin A results in increased expression of SIRT3 mRNA	CTD	PMID:35430258
Sirt3	Mouse	arsenous acid	decreases expression	ISO	RGD:1308374	6480464	Arsenic Trioxide results in decreased expression of SIRT3 mRNA	CTD	PMID:29223816
Sirt3	Mouse	arsenous acid	increases expression	ISO	RGD:1308374	6480464	Arsenic Trioxide results in increased expression of SIRT3 protein	CTD	PMID:30385301
Sirt3	Mouse	arsenous acid	multiple interactions	ISO	RGD:1308374	6480464	[Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein	CTD	PMID:30385301
Sirt3	Mouse	ATP	multiple interactions	EXP		6480464	SIRT3 protein inhibits the reaction [Metformin results in decreased abundance of Adenosine Triphosphate]	CTD	PMID:23166782
Sirt3	Mouse	atrazine	affects expression	ISO	RGD:1318106	6480464	Atrazine affects the expression of SIRT3 mRNA	CTD	PMID:27114639
Sirt3	Mouse	atrazine	decreases expression	ISO	RGD:1308374	6480464	Atrazine results in decreased expression of SIRT3 mRNA	CTD	PMID:27114639
Sirt3	Mouse	benzo[a]pyrene	decreases expression	EXP		6480464	Benzo(a)pyrene results in decreased expression of SIRT3 mRNA	CTD	PMID:19770486
Sirt3	Mouse	benzo[a]pyrene	multiple interactions	ISO	RGD:1308374	6480464	ramelteon inhibits the reaction [Benzo(a)pyrene results in increased expression of SIRT3 mRNA]; ramelteon inhibits the more ...	CTD	PMID:35940284
Sirt3	Mouse	benzo[a]pyrene	increases expression	ISO	RGD:1308374	6480464	Benzo(a)pyrene results in increased expression of SIRT3 mRNA; Benzo(a)pyrene results in increased expression of SIRT3 more ...	CTD	PMID:35940284
Sirt3	Mouse	benzo[a]pyrene	increases methylation	ISO	RGD:1318106	6480464	Benzo(a)pyrene results in increased methylation of SIRT3 3' UTR	CTD	PMID:27901495
Sirt3	Mouse	benzo[a]pyrene	increases expression	EXP		6480464	Benzo(a)pyrene results in increased expression of SIRT3 mRNA	CTD	PMID:22228805
Sirt3	Mouse	benzo[a]pyrene diol epoxide I	increases expression	ISO	RGD:1318106	6480464	7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression of SIRT3 mRNA; 7,8-Dihydro-7,8-dihydroxybenzo(a)pyrene 9,10-oxide results in increased expression more ...	CTD	PMID:35940284
Sirt3	Mouse	berberine	increases expression	ISO	RGD:1318106	6480464	Berberine results in increased expression of SIRT3 mRNA	CTD	PMID:27311644
Sirt3	Mouse	berberine	multiple interactions	ISO	RGD:1318106	6480464	[Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein	CTD	PMID:26712469
Sirt3	Mouse	berberine	decreases expression	ISO	RGD:1318106	6480464	Berberine results in decreased expression of SIRT3 mRNA; Berberine results in decreased expression of SIRT3 more ...	CTD	PMID:26712469
Sirt3	Mouse	beta-lapachone	increases expression	ISO	RGD:1318106	6480464	beta-lapachone results in increased expression of SIRT3 mRNA	CTD	PMID:38218311
Sirt3	Mouse	bis(2-ethylhexyl) phthalate	increases expression	EXP		6480464	Diethylhexyl Phthalate results in increased expression of SIRT3 mRNA; Diethylhexyl Phthalate results in increased expression more ...	CTD	PMID:33754040\|PMID:33908429\|PMID:34319233
Sirt3	Mouse	bis(2-ethylhexyl) phthalate	multiple interactions	EXP		6480464	Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of SIRT3 protein]	CTD	PMID:33908429
Sirt3	Mouse	bisphenol A	decreases expression	EXP		6480464	bisphenol A results in decreased expression of SIRT3 mRNA	CTD	PMID:25575267\|PMID:31016965\|PMID:33239236
Sirt3	Mouse	bisphenol A	multiple interactions	ISO	RGD:1308374	6480464	Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SIRT3 protein]	CTD	PMID:30641872
Sirt3	Mouse	bisphenol A	decreases expression	ISO	RGD:1308374	6480464	bisphenol A results in decreased expression of SIRT3 mRNA; bisphenol A results in decreased expression more ...	CTD	PMID:30641872\|PMID:32145629\|PMID:34947998
Sirt3	Mouse	bisphenol A	increases methylation	EXP		6480464	bisphenol A results in increased methylation of SIRT3 promoter	CTD	PMID:27312807
Sirt3	Mouse	bisphenol A	increases methylation	ISO	RGD:1308374	6480464	bisphenol A results in increased methylation of SIRT3 gene	CTD	PMID:28505145
Sirt3	Mouse	bisphenol A	increases expression	ISO	RGD:1308374	6480464	bisphenol A results in increased expression of SIRT3 mRNA	CTD	PMID:25181051
Sirt3	Mouse	Butylbenzyl phthalate	decreases expression	ISO	RGD:1318106	6480464	butylbenzyl phthalate results in decreased expression of SIRT3 mRNA; butylbenzyl phthalate results in decreased expression more ...	CTD	PMID:26520405
Sirt3	Mouse	Butylbenzyl phthalate	decreases expression	EXP		6480464	butylbenzyl phthalate results in decreased expression of SIRT3 mRNA; butylbenzyl phthalate results in decreased expression more ...	CTD	PMID:27923775\|PMID:34520170
Sirt3	Mouse	cadmium dichloride	decreases expression	ISO	RGD:1318106	6480464	Cadmium Chloride results in decreased expression of SIRT3 mRNA	CTD	PMID:38568856
Sirt3	Mouse	caffeine	multiple interactions	ISO	RGD:1318106	6480464	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 more ...	CTD	PMID:30555576
Sirt3	Mouse	carbon nanotube	decreases expression	EXP		6480464	Nanotubes, Carbon analog results in decreased expression of SIRT3 mRNA	CTD	PMID:25554681
Sirt3	Mouse	CGS-21680	multiple interactions	ISO	RGD:1318106	6480464	2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine inhibits the reaction [Caffeine inhibits the reaction [2,2'-azobis(2-amidinopropane) results in decreased expression of SIRT3 more ...	CTD	PMID:30555576
Sirt3	Mouse	chloroquine	multiple interactions	ISO	RGD:1318106	6480464	Chloroquine inhibits the reaction [hydroquinone results in decreased expression of SIRT3 mRNA]; Chloroquine inhibits the more ...	CTD	PMID:35302183
Sirt3	Mouse	chloroquine	increases stability	ISO	RGD:1318106	6480464	Chloroquine results in increased stability of SIRT3 mRNA	CTD	PMID:35302183
Sirt3	Mouse	choline	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ...	CTD	PMID:20938992
Sirt3	Mouse	chromium(6+)	affects response to substance	ISO	RGD:1318106	6480464	SIRT3 affects the susceptibility to chromium hexavalent ion	CTD	PMID:30715550
Sirt3	Mouse	chromium(6+)	multiple interactions	ISO	RGD:1318106	6480464	chromium hexavalent ion promotes the reaction [NFE2L2 protein binds to SIRT3 promoter]	CTD	PMID:30715550
Sirt3	Mouse	chromium(6+)	increases expression	ISO	RGD:1318106	6480464	chromium hexavalent ion results in increased expression of SIRT3 mRNA; chromium hexavalent ion results in more ...	CTD	PMID:30715550
Sirt3	Mouse	cisplatin	multiple interactions	ISO	RGD:1308374	6480464	Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein; Curcumin more ...	CTD	PMID:28698153\|PMID:36800006\|PMID:39102946
Sirt3	Mouse	cisplatin	multiple interactions	ISO	RGD:1318106	6480464	Cisplatin results in decreased expression of and results in decreased activity of SIRT3 protein; N-(oxo-5,6-dihydrophenanthridin-2-yl)-N,N-dimethylacetamide more ...	CTD	PMID:27722009
Sirt3	Mouse	cisplatin	affects response to substance	ISO	RGD:1318106	6480464	SIRT3 protein affects the susceptibility to Cisplatin	CTD	PMID:27722009
Sirt3	Mouse	cisplatin	multiple interactions	EXP		6480464	SIRT3 promotes the reaction [Metformin inhibits the reaction [Cisplatin affects the localization of SLC2A4 protein]]; more ...	CTD	PMID:36800006
Sirt3	Mouse	cisplatin	decreases expression	ISO	RGD:1308374	6480464	Cisplatin results in decreased expression of SIRT3 mRNA; Cisplatin results in decreased expression of SIRT3 more ...	CTD	PMID:36800006\|PMID:39102946
Sirt3	Mouse	cisplatin	decreases response to substance	ISO	RGD:1318106	6480464	SIRT3 protein results in decreased susceptibility to Cisplatin	CTD	PMID:21472714
Sirt3	Mouse	copper(II) sulfate	decreases expression	ISO	RGD:1318106	6480464	Copper Sulfate results in decreased expression of SIRT3 mRNA	CTD	PMID:19549813
Sirt3	Mouse	curcumin	multiple interactions	ISO	RGD:1308374	6480464	Curcumin inhibits the reaction [[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of more ...	CTD	PMID:28698153\|PMID:28951138
Sirt3	Mouse	curcumin	multiple interactions	ISO	RGD:1318106	6480464	Curcumin inhibits the reaction [[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the more ...	CTD	PMID:26422756
Sirt3	Mouse	cyclophosphamide	multiple interactions	EXP		6480464	Carnitine inhibits the reaction [Cyclophosphamide results in increased expression of SIRT3 mRNA]	CTD	PMID:37863343
Sirt3	Mouse	cyclophosphamide	increases expression	EXP		6480464	Cyclophosphamide results in increased expression of SIRT3 mRNA	CTD	PMID:37863343
Sirt3	Mouse	D-glucose	multiple interactions	EXP		6480464	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased more ...	CTD	PMID:25979314
Sirt3	Mouse	D-glucose	decreases expression	ISO	RGD:1318106	6480464	Glucose results in decreased expression of SIRT3 protein	CTD	PMID:37417536
Sirt3	Mouse	D-glucose	multiple interactions	ISO	RGD:1308374	6480464	formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the more ...	CTD	PMID:37944786
Sirt3	Mouse	D-glucose	decreases expression	ISO	RGD:1308374	6480464	Glucose results in decreased expression of SIRT3 mRNA; Glucose results in decreased expression of SIRT3 more ...	CTD	PMID:37944786
Sirt3	Mouse	D-glucose	increases expression	ISO	RGD:1318106	6480464	Glucose deficiency results in increased expression of SIRT3 protein	CTD	PMID:23494737
Sirt3	Mouse	D-glucose	multiple interactions	ISO	RGD:1318106	6480464	polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]; SIRT3 more ...	CTD	PMID:23494737\|PMID:37417536
Sirt3	Mouse	deguelin	decreases expression	ISO	RGD:1318106	6480464	deguelin results in decreased expression of SIRT3 mRNA	CTD	PMID:33512557
Sirt3	Mouse	diarsenic trioxide	multiple interactions	ISO	RGD:1308374	6480464	[Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein	CTD	PMID:30385301
Sirt3	Mouse	diarsenic trioxide	decreases expression	ISO	RGD:1308374	6480464	Arsenic Trioxide results in decreased expression of SIRT3 mRNA	CTD	PMID:29223816
Sirt3	Mouse	diarsenic trioxide	increases expression	ISO	RGD:1308374	6480464	Arsenic Trioxide results in increased expression of SIRT3 protein	CTD	PMID:30385301
Sirt3	Mouse	diazinon	increases methylation	ISO	RGD:1318106	6480464	Diazinon results in increased methylation of SIRT3 gene	CTD	PMID:22964155
Sirt3	Mouse	Dibutyl phosphate	affects expression	ISO	RGD:1318106	6480464	di-n-butylphosphoric acid affects the expression of SIRT3 mRNA	CTD	PMID:37042841
Sirt3	Mouse	dibutyl phthalate	decreases expression	ISO	RGD:1308374	6480464	Dibutyl Phthalate results in decreased expression of SIRT3 mRNA	CTD	PMID:21266533
Sirt3	Mouse	diethylstilbestrol	decreases expression	EXP		6480464	Diethylstilbestrol results in decreased expression of SIRT3 mRNA	CTD	PMID:25575267
Sirt3	Mouse	diisononyl phthalate	decreases expression	ISO	RGD:1318106	6480464	diisononyl phthalate results in decreased expression of SIRT3 mRNA; diisononyl phthalate results in decreased expression more ...	CTD	PMID:31423773
Sirt3	Mouse	Diosbulbin B	decreases expression	EXP		6480464	diosbulbin B results in decreased expression of SIRT3 mRNA	CTD	PMID:39368342
Sirt3	Mouse	doxorubicin	decreases expression	ISO	RGD:1308374	6480464	Doxorubicin results in decreased expression of SIRT3 protein	CTD	PMID:26678157
Sirt3	Mouse	doxorubicin	decreases expression	ISO	RGD:1318106	6480464	Doxorubicin results in decreased expression of SIRT3 mRNA	CTD	PMID:29803840
Sirt3	Mouse	estriol	decreases expression	EXP		6480464	Estriol results in decreased expression of SIRT3 mRNA	CTD	PMID:25575267
Sirt3	Mouse	ethanol	increases metabolic processing	EXP		6480464	Ethanol results in increased metabolism of SIRT3 protein	CTD	PMID:21449565
Sirt3	Mouse	ethanol	increases expression	ISO	RGD:1308374	6480464	Ethanol results in increased expression of SIRT3 mRNA	CTD	PMID:18793633
Sirt3	Mouse	ethanol	multiple interactions	ISO	RGD:1308374	6480464	1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results more ...	CTD	PMID:18793633\|PMID:35872049
Sirt3	Mouse	flutamide	decreases expression	ISO	RGD:1308374	6480464	Flutamide results in decreased expression of SIRT3 mRNA	CTD	PMID:24136188
Sirt3	Mouse	folic acid	multiple interactions	EXP		6480464	[1,2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of SIRT3 mRNA; [Methionine deficiency co-treated more ...	CTD	PMID:20938992\|PMID:22206623
Sirt3	Mouse	formononetin	affects binding	ISO	RGD:1308374	6480464	formononetin binds to SIRT3 protein	CTD	PMID:37944786
Sirt3	Mouse	formononetin	multiple interactions	ISO	RGD:1308374	6480464	formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the more ...	CTD	PMID:37944786
Sirt3	Mouse	gemcitabine	multiple interactions	EXP		6480464	[3-(carbamoylamino)-5-(3-fluorophenyl)-N-(3-piperidyl)thiophene-2-carboxamide co-treated with Gemcitabine] results in decreased expression of SIRT3 protein	CTD	PMID:37798514
Sirt3	Mouse	gemcitabine	decreases expression	EXP		6480464	Gemcitabine results in decreased expression of SIRT3 protein	CTD	PMID:37798514
Sirt3	Mouse	gentamycin	increases expression	ISO	RGD:1308374	6480464	Gentamicins results in increased expression of SIRT3 mRNA	CTD	PMID:33387578
Sirt3	Mouse	glucose	multiple interactions	EXP		6480464	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [INS1 protein results in increased more ...	CTD	PMID:25979314
Sirt3	Mouse	glucose	decreases expression	ISO	RGD:1318106	6480464	Glucose results in decreased expression of SIRT3 protein	CTD	PMID:37417536
Sirt3	Mouse	glucose	decreases expression	ISO	RGD:1308374	6480464	Glucose results in decreased expression of SIRT3 mRNA; Glucose results in decreased expression of SIRT3 more ...	CTD	PMID:37944786
Sirt3	Mouse	glucose	multiple interactions	ISO	RGD:1308374	6480464	formononetin inhibits the reaction [Glucose results in decreased expression of SIRT3 mRNA]; formononetin inhibits the more ...	CTD	PMID:37944786
Sirt3	Mouse	glucose	increases expression	ISO	RGD:1318106	6480464	Glucose deficiency results in increased expression of SIRT3 protein	CTD	PMID:23494737
Sirt3	Mouse	glucose	multiple interactions	ISO	RGD:1318106	6480464	polyethylene glycol loxenatide inhibits the reaction [Glucose results in decreased expression of SIRT3 protein]; SIRT3 more ...	CTD	PMID:23494737\|PMID:37417536
Sirt3	Mouse	GSK-J4	decreases expression	ISO	RGD:1318106	6480464	GSK-J4 results in decreased expression of SIRT3 mRNA	CTD	PMID:29301935
Sirt3	Mouse	hesperetin	affects binding	ISO	RGD:1318106	6480464	hesperetin binds to SIRT3 protein	CTD	PMID:37487865
Sirt3	Mouse	hexadecanoic acid	decreases expression	ISO	RGD:1318106	6480464	Palmitic Acid results in decreased expression of SIRT3 protein	CTD	PMID:30958623
Sirt3	Mouse	Honokiol	multiple interactions	ISO	RGD:1308374	6480464	honokiol inhibits the reaction [amyloid beta-protein (1-42) results in decreased expression of SIRT3 protein]; honokiol more ...	CTD	PMID:33522075\|PMID:34752757
Sirt3	Mouse	hydrogen peroxide	decreases expression	ISO	RGD:1308374	6480464	Hydrogen Peroxide results in decreased expression of SIRT3 mRNA; Hydrogen Peroxide results in decreased expression more ...	CTD	PMID:30104959
Sirt3	Mouse	hydrogen peroxide	multiple interactions	ISO	RGD:1308374	6480464	Acetylcysteine inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; Acetylcysteine inhibits more ...	CTD	PMID:30104959
Sirt3	Mouse	hydrogen peroxide	multiple interactions	ISO	RGD:1318106	6480464	[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results more ...	CTD	PMID:26422756
Sirt3	Mouse	hydrogen peroxide	decreases expression	ISO	RGD:1318106	6480464	Hydrogen Peroxide results in decreased expression of SIRT3 mRNA; Hydrogen Peroxide results in decreased expression more ...	CTD	PMID:26422756
Sirt3	Mouse	hydrogen sulfide	multiple interactions	ISO	RGD:1318106	6480464	[GYY 4137 results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Hydrogen Peroxide results more ...	CTD	PMID:26422756
Sirt3	Mouse	hydrogen sulfide	multiple interactions	ISO	RGD:1308374	6480464	[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in more ...	CTD	PMID:32064027
Sirt3	Mouse	hydroquinone	multiple interactions	ISO	RGD:1318106	6480464	[[NOX4 protein results in decreased expression of ELAVL2 protein] which promotes the reaction SIDT2 protein] more ...	CTD	PMID:35302183
Sirt3	Mouse	hydroquinone	increases degradation	ISO	RGD:1318106	6480464	hydroquinone results in increased degradation of SIRT3 mRNA	CTD	PMID:35302183
Sirt3	Mouse	hydroquinone	decreases expression	ISO	RGD:1318106	6480464	hydroquinone results in decreased expression of SIRT3 mRNA; hydroquinone results in decreased expression of SIRT3 more ...	CTD	PMID:35302183
Sirt3	Mouse	icariin	multiple interactions	ISO	RGD:1308374	6480464	Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression more ...	CTD	PMID:31251943
Sirt3	Mouse	L-methionine	multiple interactions	EXP		6480464	[Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in decreased methylation more ...	CTD	PMID:20938992
Sirt3	Mouse	lead diacetate	multiple interactions	EXP		6480464	PPARGC1A protein affects the reaction [lead acetate results in increased expression of SIRT3 protein]	CTD	PMID:27236077
Sirt3	Mouse	lead diacetate	increases expression	EXP		6480464	lead acetate results in increased expression of SIRT3 protein	CTD	PMID:27236077
Sirt3	Mouse	linagliptin	multiple interactions	ISO	RGD:1308374	6480464	Linagliptin inhibits the reaction [Cisplatin results in decreased expression of SIRT3 mRNA]	CTD	PMID:39102946
Sirt3	Mouse	linalool	decreases expression	ISO	RGD:1318106	6480464	linalool results in decreased expression of SIRT3 mRNA; linalool results in decreased expression of SIRT3 more ...	CTD	PMID:28567457
Sirt3	Mouse	linalool	multiple interactions	ISO	RGD:1318106	6480464	linalool inhibits the reaction [SOD2 protein binds to SIRT3 protein]	CTD	PMID:28567457
Sirt3	Mouse	lipoic acid	multiple interactions	ISO	RGD:1308374	6480464	[Thioctic Acid results in increased expression of [SIRT1 protein co-treated with SIRT3 protein]] which results more ...	CTD	PMID:22327056
Sirt3	Mouse	lipoic acid	multiple interactions	EXP		6480464	Thioctic Acid inhibits the reaction [Sodium Fluoride results in decreased expression of SIRT3 mRNA]	CTD	PMID:37739047
Sirt3	Mouse	lipoic acid	increases expression	ISO	RGD:1308374	6480464	Thioctic Acid results in increased expression of SIRT3 protein	CTD	PMID:22327056
Sirt3	Mouse	lipopolysaccharide	multiple interactions	ISO	RGD:1308374	6480464	[Lipopolysaccharides co-treated with Tobacco Smoke Pollution] results in decreased expression of SIRT3 mRNA; [Lipopolysaccharides co-treated more ...	CTD	PMID:28951138
Sirt3	Mouse	lycopene	multiple interactions	EXP		6480464	Lycopene inhibits the reaction [Diethylhexyl Phthalate results in increased expression of SIRT3 protein]	CTD	PMID:33908429
Sirt3	Mouse	mancozeb	decreases activity	ISO	RGD:1318106	6480464	mancozeb results in decreased activity of SIRT3 protein	CTD	PMID:21251949
Sirt3	Mouse	maneb	decreases activity	ISO	RGD:1318106	6480464	Maneb results in decreased activity of SIRT3 protein	CTD	PMID:21251949
Sirt3	Mouse	melatonin	multiple interactions	ISO	RGD:1308374	6480464	Melatonin inhibits the reaction [Monocrotaline results in decreased expression of SIRT3 mRNA]; Melatonin inhibits the more ...	CTD	PMID:37350538
Sirt3	Mouse	melatonin	multiple interactions	EXP		6480464	Melatonin inhibits the reaction [[Particulate Matter co-treated with Dietary Fats] results in decreased expression of more ...	CTD	PMID:37994397
Sirt3	Mouse	metformin	decreases expression	EXP		6480464	Metformin results in decreased expression of SIRT3 mRNA; Metformin results in decreased expression of SIRT3 more ...	CTD	PMID:23166782\|PMID:24687991
Sirt3	Mouse	metformin	multiple interactions	ISO	RGD:1318106	6480464	Metformin results in increased expression of and results in increased activity of SIRT3 protein	CTD	PMID:33147367
Sirt3	Mouse	metformin	increases expression	ISO	RGD:1308374	6480464	Metformin results in increased expression of SIRT3 protein	CTD	PMID:30385301
Sirt3	Mouse	metformin	multiple interactions	ISO	RGD:1308374	6480464	[Arsenic Trioxide co-treated with Metformin] results in increased expression of SIRT3 protein; Metformin inhibits the more ...	CTD	PMID:30385301\|PMID:36800006
Sirt3	Mouse	metformin	decreases response to substance	EXP		6480464	SIRT3 protein results in decreased susceptibility to Metformin	CTD	PMID:23166782
Sirt3	Mouse	metformin	multiple interactions	EXP		6480464	Metformin inhibits the reaction [GCG protein results in increased expression of SIRT3 mRNA]; SIRT3 promotes more ...	CTD	PMID:23166782\|PMID:36800006
Sirt3	Mouse	methimazole	decreases expression	ISO	RGD:1308374	6480464	Methimazole results in decreased expression of SIRT3 mRNA	CTD	PMID:30047161
Sirt3	Mouse	methotrexate	affects expression	EXP		6480464	Methotrexate affects the expression of SIRT3 mRNA	CTD	PMID:18502557
Sirt3	Mouse	metiram	decreases activity	ISO	RGD:1318106	6480464	polymarcine results in decreased activity of SIRT3 protein	CTD	PMID:21251949
Sirt3	Mouse	mono(2-ethylhexyl) phthalate	increases expression	EXP		6480464	mono-(2-ethylhexyl)phthalate results in increased expression of SIRT3 mRNA	CTD	PMID:25543134\|PMID:32522588
Sirt3	Mouse	mono(2-ethylhexyl) phthalate	decreases expression	EXP		6480464	mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT3 mRNA; mono-(2-ethylhexyl)phthalate results in decreased expression of SIRT3 more ...	CTD	PMID:31016965
Sirt3	Mouse	monocrotaline	multiple interactions	ISO	RGD:1308374	6480464	Melatonin inhibits the reaction [Monocrotaline results in decreased expression of SIRT3 mRNA]; Melatonin inhibits the more ...	CTD	PMID:37350538
Sirt3	Mouse	monocrotaline	decreases expression	ISO	RGD:1308374	6480464	Monocrotaline results in decreased expression of SIRT3 mRNA; Monocrotaline results in decreased expression of SIRT3 more ...	CTD	PMID:37350538
Sirt3	Mouse	N-acetyl-L-cysteine	multiple interactions	ISO	RGD:1308374	6480464	Acetylcysteine inhibits the reaction [bisphenol A results in decreased expression of SIRT3 protein]; Acetylcysteine inhibits more ...	CTD	PMID:30104959\|PMID:30641872
Sirt3	Mouse	N-acetyl-L-cysteine	multiple interactions	ISO	RGD:1318106	6480464	Acetylcysteine inhibits the reaction [Antimycin A results in increased expression of SIRT3 mRNA]	CTD	PMID:35430258
Sirt3	Mouse	N-methyl-4-phenylpyridinium	increases expression	ISO	RGD:1308374	6480464	1-Methyl-4-phenylpyridinium results in increased expression of SIRT3 mRNA	CTD	PMID:28801915
Sirt3	Mouse	N-methyl-4-phenylpyridinium	decreases expression	EXP		6480464	1-Methyl-4-phenylpyridinium results in decreased expression of SIRT3 protein	CTD	PMID:33994527
Sirt3	Mouse	N-methyl-4-phenylpyridinium	multiple interactions	EXP		6480464	salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT3 protein]	CTD	PMID:33994527
Sirt3	Mouse	nebivolol	increases expression	EXP		6480464	Nebivolol results in increased expression of SIRT3 protein	CTD	PMID:23886954
Sirt3	Mouse	nebivolol	multiple interactions	EXP		6480464	3-(2-ethylphenoxy)-1-(1,2,3,4-tetrahydronaphth-1-ylamino)-2-propanol oxalate inhibits the reaction [Nebivolol results in increased expression of SIRT3 protein]	CTD	PMID:23886954
Sirt3	Mouse	nicotinamide	multiple interactions	ISO	RGD:1318106	6480464	[Berberine co-treated with Niacinamide] results in decreased expression of SIRT3 protein	CTD	PMID:26712469
Sirt3	Mouse	nitrates	multiple interactions	EXP		6480464	[Particulate Matter results in increased abundance of Nitrates] which results in increased expression of SIRT3 more ...	CTD	PMID:35964746
Sirt3	Mouse	okadaic acid	decreases expression	ISO	RGD:1318106	6480464	Okadaic Acid results in decreased expression of SIRT3 mRNA	CTD	PMID:38832940
Sirt3	Mouse	paracetamol	affects expression	EXP		6480464	Acetaminophen affects the expression of SIRT3 mRNA	CTD	PMID:17562736
Sirt3	Mouse	paracetamol	increases expression	ISO	RGD:1308374	6480464	Acetaminophen results in increased expression of SIRT3 mRNA	CTD	PMID:33387578
Sirt3	Mouse	paraquat	multiple interactions	ISO	RGD:1308374	6480464	[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in more ...	CTD	PMID:32064027
Sirt3	Mouse	paraquat	decreases expression	ISO	RGD:1308374	6480464	Paraquat results in decreased expression of SIRT3 protein	CTD	PMID:32064027
Sirt3	Mouse	perfluorooctane-1-sulfonic acid	decreases expression	ISO	RGD:1318106	6480464	perfluorooctane sulfonic acid results in decreased expression of SIRT3 mRNA; perfluorooctane sulfonic acid results in more ...	CTD	PMID:31508952
Sirt3	Mouse	perfluorooctane-1-sulfonic acid	multiple interactions	EXP		6480464	[perfluorooctane sulfonic acid co-treated with Cellulose] results in decreased expression of SIRT3 mRNA	CTD	PMID:36331819
Sirt3	Mouse	perfluorooctane-1-sulfonic acid	increases expression	EXP		6480464	perfluorooctane sulfonic acid results in increased expression of SIRT3 mRNA	CTD	PMID:31016965
Sirt3	Mouse	perfluorooctanoic acid	increases expression	EXP		6480464	perfluorooctanoic acid results in increased expression of SIRT3 mRNA	CTD	PMID:31016965
Sirt3	Mouse	pregnenolone 16alpha-carbonitrile	decreases expression	ISO	RGD:1308374	6480464	Pregnenolone Carbonitrile results in decreased expression of SIRT3 mRNA	CTD	PMID:30047161
Sirt3	Mouse	propiconazole	decreases expression	EXP		6480464	propiconazole results in decreased expression of SIRT3 mRNA	CTD	PMID:21278054
Sirt3	Mouse	propionic acid	increases expression	ISO	RGD:1318106	6480464	propionic acid results in increased expression of SIRT3 mRNA; propionic acid results in increased expression more ...	CTD	PMID:31526819
Sirt3	Mouse	reactive oxygen species	multiple interactions	ISO	RGD:1318106	6480464	SIRT3 protein inhibits the reaction [Particulate Matter results in increased abundance of Reactive Oxygen Species]	CTD	PMID:27125970
Sirt3	Mouse	resveratrol	decreases expression	ISO	RGD:1318106	6480464	resveratrol results in decreased expression of SIRT3 mRNA	CTD	PMID:21980390
Sirt3	Mouse	resveratrol	decreases expression	EXP		6480464	resveratrol results in decreased expression of SIRT3 mRNA	CTD	PMID:23525482
Sirt3	Mouse	resveratrol	increases activity	ISO	RGD:1318106	6480464	resveratrol results in increased activity of SIRT3 protein	CTD	PMID:24178296
Sirt3	Mouse	resveratrol	multiple interactions	ISO	RGD:1308374	6480464	resveratrol inhibits the reaction [Dietary Fats results in decreased expression of SIRT3 protein]; resveratrol inhibits more ...	CTD	PMID:18793633\|PMID:25686565
Sirt3	Mouse	resveratrol	increases expression	ISO	RGD:1318106	6480464	resveratrol results in increased expression of SIRT3 mRNA	CTD	PMID:25522270
Sirt3	Mouse	resveratrol	multiple interactions	ISO	RGD:1318106	6480464	PPARGC1A mutant form inhibits the reaction [resveratrol results in increased expression of SIRT3 mRNA]; PPARGC1A more ...	CTD	PMID:22585829\|PMID:25522270
Sirt3	Mouse	rotenone	multiple interactions	ISO	RGD:1318106	6480464	SIRT3 protein inhibits the reaction [Rotenone results in increased expression of SNCA protein]	CTD	PMID:27053302
Sirt3	Mouse	rotenone	multiple interactions	ISO	RGD:1308374	6480464	Histone Deacetylase Inhibitors inhibits the reaction [icariin inhibits the reaction [Rotenone results in decreased expression more ...	CTD	PMID:31251943
Sirt3	Mouse	rotenone	decreases expression	ISO	RGD:1308374	6480464	Rotenone results in decreased expression of SIRT3 protein	CTD	PMID:31251943
Sirt3	Mouse	salvianolic acid B	multiple interactions	EXP		6480464	salvianolic acid B inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of SIRT3 protein]	CTD	PMID:33994527
Sirt3	Mouse	sodium arsenite	multiple interactions	EXP		6480464	SIRT3 protein inhibits the reaction [sodium arsenite inhibits the reaction [FOXO3 protein binds to PPARGC1A more ...	CTD	PMID:25979314
Sirt3	Mouse	sodium arsenite	decreases expression	ISO	RGD:1318106	6480464	sodium arsenite results in decreased expression of SIRT3 mRNA	CTD	PMID:38568856
Sirt3	Mouse	sodium arsenite	decreases expression	EXP		6480464	sodium arsenite results in decreased expression of SIRT3 protein	CTD	PMID:25979314
Sirt3	Mouse	sodium fluoride	multiple interactions	EXP		6480464	[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of SIRT3 more ...	CTD	PMID:34780879\|PMID:37739047
Sirt3	Mouse	sodium fluoride	decreases expression	EXP		6480464	Sodium Fluoride results in decreased expression of SIRT3 mRNA	CTD	PMID:37739047
Sirt3	Mouse	sodium fluoride	multiple interactions	ISO	RGD:1308374	6480464	[Sodium Fluoride results in increased abundance of Fluorides] which results in increased expression of SIRT3 more ...	CTD	PMID:39012504
Sirt3	Mouse	sodium fluoride	multiple interactions	ISO	RGD:1318106	6480464	[Sodium Fluoride results in increased abundance of Fluorides] which results in decreased expression of SIRT3 more ...	CTD	PMID:34780879\|PMID:39012504
Sirt3	Mouse	sodium sulfide (anhydrous)	multiple interactions	ISO	RGD:1308374	6480464	[sodium sulfide results in increased abundance of Hydrogen Sulfide] inhibits the reaction [Paraquat results in more ...	CTD	PMID:32064027
Sirt3	Mouse	Soman	decreases expression	ISO	RGD:1308374	6480464	Soman results in decreased expression of SIRT3 mRNA	CTD	PMID:19281266
Sirt3	Mouse	stavudine	increases expression	ISO	RGD:1318106	6480464	Stavudine results in increased expression of SIRT3 protein	CTD	PMID:27041070
Sirt3	Mouse	sulfadimethoxine	decreases expression	ISO	RGD:1308374	6480464	Sulfadimethoxine results in decreased expression of SIRT3 mRNA	CTD	PMID:30047161
Sirt3	Mouse	tenofovir disoproxil fumarate	increases expression	ISO	RGD:1318106	6480464	Tenofovir results in increased expression of SIRT3 protein	CTD	PMID:27041070
Sirt3	Mouse	tert-butyl hydroperoxide	multiple interactions	ISO	RGD:1318106	6480464	SIRT3 mutant form inhibits the reaction [resveratrol inhibits the reaction [tert-Butylhydroperoxide results in decreased activity more ...	CTD	PMID:25522270
Sirt3	Mouse	tetrachloromethane	decreases expression	EXP		6480464	Carbon Tetrachloride results in decreased expression of SIRT3 mRNA; Carbon Tetrachloride results in decreased expression more ...	CTD	PMID:27339419\|PMID:30368983\|PMID:31919559
Sirt3	Mouse	tetrachloromethane	decreases expression	ISO	RGD:1308374	6480464	Carbon Tetrachloride results in decreased expression of SIRT3 mRNA	CTD	PMID:31150632
Sirt3	Mouse	tetrachloromethane	multiple interactions	EXP		6480464	[mangostin co-treated with Carbon Tetrachloride] results in increased expression of and results in increased secretion more ...	CTD	PMID:30368983\|PMID:30502394
Sirt3	Mouse	tetrachloromethane	multiple interactions	ISO	RGD:1308374	6480464	1,3,7,9-tetramethyluric acid inhibits the reaction [[Dietary Fats co-treated with Ethanol co-treated with Carbon Tetrachloride] results more ...	CTD	PMID:31150632\|PMID:35872049
Sirt3	Mouse	tetrachloromethane	decreases response to substance	EXP		6480464	SIRT3 protein results in decreased susceptibility to Carbon Tetrachloride	CTD	PMID:30368983
Sirt3	Mouse	thapsigargin	decreases expression	ISO	RGD:1318106	6480464	Thapsigargin results in decreased expression of SIRT3 mRNA	CTD	PMID:22378314
Sirt3	Mouse	thioacetamide	multiple interactions	ISO	RGD:1308374	6480464	honokiol inhibits the reaction [Thioacetamide results in decreased expression of and results in decreased activity more ...	CTD	PMID:33522075
Sirt3	Mouse	thioacetamide	decreases expression	ISO	RGD:1308374	6480464	Thioacetamide results in decreased expression of SIRT3 mRNA	CTD	PMID:34492290
Sirt3	Mouse	thiram	decreases expression	ISO	RGD:1318106	6480464	Thiram results in decreased expression of SIRT3 mRNA	CTD	PMID:38568856
Sirt3	Mouse	titanium dioxide	decreases methylation	EXP		6480464	titanium dioxide results in decreased methylation of SIRT3 gene; titanium dioxide results in decreased methylation more ...	CTD	PMID:35295148
Sirt3	Mouse	trichloroethene	increases expression	ISO	RGD:1308374	6480464	Trichloroethylene results in increased expression of SIRT3 mRNA	CTD	PMID:33387578
Sirt3	Mouse	trilobatin	multiple interactions	ISO	RGD:1308374	6480464	trilobatin inhibits the reaction [Hydrogen Peroxide results in decreased expression of SIRT3 mRNA]; trilobatin inhibits more ...	CTD	PMID:30104959
Sirt3	Mouse	triptonide	increases expression	EXP		6480464	triptonide results in increased expression of SIRT3 mRNA	CTD	PMID:33045310
Sirt3	Mouse	tris(2-chloroethyl) phosphate	decreases expression	ISO	RGD:1318106	6480464	tris(chloroethyl)phosphate results in decreased expression of SIRT3 mRNA; tris(chloroethyl)phosphate results in decreased expression of SIRT3 more ...	CTD	PMID:30090360
Sirt3	Mouse	tunicamycin	decreases expression	ISO	RGD:1318106	6480464	Tunicamycin results in decreased expression of SIRT3 mRNA	CTD	PMID:22378314
Sirt3	Mouse	urethane	decreases expression	ISO	RGD:1318106	6480464	Urethane results in decreased expression of SIRT3 mRNA	CTD	PMID:28818685
Sirt3	Mouse	valdecoxib	decreases expression	ISO	RGD:1308374	6480464	valdecoxib results in decreased expression of SIRT3 mRNA	CTD	PMID:24136188
Sirt3	Mouse	valproic acid	decreases methylation	ISO	RGD:1318106	6480464	Valproic Acid results in decreased methylation of SIRT3 gene	CTD	PMID:29154799
Sirt3	Mouse	vancomycin	increases expression	EXP		6480464	Vancomycin results in increased expression of SIRT3 mRNA	CTD	PMID:18930951
Sirt3	Mouse	vosaroxin	multiple interactions	ISO	RGD:1318106	6480464	SIRT3 protein inhibits the reaction [vosaroxin results in decreased expression of HIF1A protein]	CTD	PMID:29800573
Sirt3	Mouse	zidovudine	increases expression	ISO	RGD:1318106	6480464	Zidovudine results in increased expression of SIRT3 protein	CTD	PMID:27041070

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	aerobic respiration	involved_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	aerobic respiration	involved_in	ISS	UniProtKB:Q9NTG7	2290270		UniProt	GO_REF:0000024
Sirt3	Mouse	negative regulation of ERK1 and ERK2 cascade		ISO	RGD:1308374	9068941		RGD	PMID:23397292\|REF_RGD_ID:9586042
Sirt3	Mouse	negative regulation of ERK1 and ERK2 cascade	involved_in	ISO	RGD:1308374	2290270		GO_Central	GO_REF:0000096
Sirt3	Mouse	negative regulation of peptidyl-lysine acetylation	acts_upstream_of_or_within	IDA		2290270	PMID:17923681	MGI	PMID:17923681
Sirt3	Mouse	negative regulation of peptidyl-lysine acetylation	acts_upstream_of_or_within	IMP	MGI:3769234	2290270	PMID:17923681	MGI	PMID:17923681
Sirt3	Mouse	negative regulation of reactive oxygen species metabolic process	involved_in	ISO	RGD:1308374	2290270		GO_Central	GO_REF:0000096
Sirt3	Mouse	negative regulation of reactive oxygen species metabolic process		ISO	RGD:1308374	9068941		RGD	PMID:23397292\|REF_RGD_ID:9586042
Sirt3	Mouse	peptidyl-lysine deacetylation	involved_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	peptidyl-lysine deacetylation	involved_in	IDA		2290270	PMID:26620563	UniProt	PMID:26620563
Sirt3	Mouse	peptidyl-lysine deacetylation	involved_in	ISS	UniProtKB:Q9NTG7	2290270		UniProt	GO_REF:0000024
Sirt3	Mouse	positive regulation of catalase activity	involved_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	positive regulation of ceramide biosynthetic process	involved_in	IDA		2290270	PMID:26620563	UniProt	PMID:26620563
Sirt3	Mouse	positive regulation of insulin secretion	involved_in	ISO	RGD:1308374	2290270		GO_Central	GO_REF:0000096
Sirt3	Mouse	positive regulation of insulin secretion		ISO	RGD:1308374	9068941		RGD	PMID:23397292\|REF_RGD_ID:9586042
Sirt3	Mouse	positive regulation of mitochondrial transcription	involved_in	IMP		2290270	PMID:23283301	UniProt	PMID:23283301
Sirt3	Mouse	positive regulation of oxidative phosphorylation	involved_in	ISO	RGD:1318106	9068941	PMID:25023514	FlyBase	PMID:25023514
Sirt3	Mouse	positive regulation of superoxide dismutase activity	involved_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	protein deacetylation	involved_in	ISS	UniProtKB:Q9NTG7	2290270		UniProt	GO_REF:0000024
Sirt3	Mouse	protein deacetylation	involved_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	protein deacetylation	acts_upstream_of_or_within	IMP	MGI:3769234	2290270	PMID:23576753	MGI	PMID:23576753
Sirt3	Mouse	tricarboxylic acid cycle	acts_upstream_of_or_within	IMP	MGI:5805498	2290270	PMID:31469588	MGI	PMID:31469588

Cellular Component

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	membrane	located_in	IDA		2290270	PMID:11056054	MGI	PMID:11056054
Sirt3	Mouse	mitochondrial inner membrane	located_in	IDA		2290270	PMID:18054327	CACAO	PMID:18054327
Sirt3	Mouse	mitochondrial matrix	part_of	ISO	RGD:1318106	9068941	PMID:12186850	CACAO	PMID:12186850
Sirt3	Mouse	mitochondrial matrix	located_in	IDA		2290270	PMID:17923681	MGI	PMID:17923681
Sirt3	Mouse	mitochondrial matrix	located_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	mitochondrion	is_active_in	ISO	RGD:1318106	9068941	PMID:25023514	FlyBase	PMID:25023514
Sirt3	Mouse	mitochondrion	located_in	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	mitochondrion	located_in	IDA		2290270	PMID:17923681, PMID:26767982	MGI	PMID:17923681\|PMID:26767982
Sirt3	Mouse	mitochondrion	located_in	HDA		2290270	PMID:18614015	MGI	PMID:18614015
Sirt3	Mouse	mitochondrion	located_in	ISS	UniProtKB:Q9NTG7	2290270		UniProt	GO_REF:0000024
Sirt3	Mouse	nucleus	is_active_in	IBA	PANTHER:PTN008492176\|UniProtKB:Q9NRC8\|SGD:S000005429\|PomBase:SPAC1783.04c\|UniProtKB:Q8IE47\|TAIR:locus:2162112\|UniProtKB:Q8N6T7\|FB:FBgn0037802\|CGD:CAL0000190389\|UniProtKB:Q57V41\|WB:WBGene00004800\|FB:FBgn0024291\|UniProtKB:Q96EB6\|SGD:S000002599\|UniProtKB:A7LKB1\|RGD:1308542\|MGI:1354161\|SGD:S000002200\|dictyBase:DDB_G0289967\|CGD:CAL0000181323\|SGD:S000005936\|UniProtKB:Q8IXJ6\|MGI:2135607\|WB:WBGene00004803\|PomBase:SPBC16D10.07c\|FB:FBgn0038788\|MGI:1927664\|dictyBase:DDB_G0270928	2290270		GO_Central	GO_REF:0000033
Sirt3	Mouse	protein-containing complex	part_of	IDA		2290270	PMID:23283301	UniProt	PMID:23283301
Sirt3	Mouse	protein-containing complex	part_of	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119

Molecular Function

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	enzyme binding		ISO	RGD:3732	9068941		RGD	PMID:24505357\|REF_RGD_ID:8158103
Sirt3	Mouse	enzyme binding	enables	ISO	RGD:1308374	2290270		GO_Central	GO_REF:0000096
Sirt3	Mouse	histone deacetylase activity, NAD-dependent	enables	IBA	PANTHER:PTN000119154\|SGD:S000005936\|FB:FBgn0037802\|PomBase:SPCC132.02\|UniProtKB:Q8N6T7\|PomBase:SPAC1783.04c\|UniProtKB:Q9NRC8\|SGD:S000005551\|SGD:S000005429\|RGD:1308542\|PomBase:SPBC16D10.07c\|UniProtKB:C8V3W5\|MGI:1354161\|SGD:S000002200\|FB:FBgn0038788\|FB:FBgn0024291\|MGI:2135607\|UniProtKB:Q57V41\|UniProtKB:Q8IXJ6\|UniProtKB:Q96EB6\|SGD:S000002599\|MGI:2385849	2290270		GO_Central	GO_REF:0000033
Sirt3	Mouse	histone H3K14 deacetylase activity, NAD-dependent	enables	IEA	EC:2.3.1.286	2290270		UniProt	GO_REF:0000003
Sirt3	Mouse	histone H3K18 deacetylase activity, NAD-dependent	enables	IEA	EC:2.3.1.286	2290270		UniProt	GO_REF:0000003
Sirt3	Mouse	histone H3K4 deacetylase activity, NAD-dependent	enables	IEA	EC:2.3.1.286	2290270		UniProt	GO_REF:0000003
Sirt3	Mouse	histone H3K56 deacetylase activity, NAD-dependent	enables	IEA	EC:2.3.1.286	2290270		UniProt	GO_REF:0000003
Sirt3	Mouse	histone H3K9 deacetylase activity, NAD-dependent	enables	IEA	EC:2.3.1.286	2290270		UniProt	GO_REF:0000003
Sirt3	Mouse	histone H4K16 deacetylase activity, NAD-dependent	enables	IEA	EC:2.3.1.286	2290270		UniProt	GO_REF:0000003
Sirt3	Mouse	NAD+ binding	enables	IBA	PANTHER:PTN000119154\|UniProtKB:Q9NXA8\|UniProtKB:Q8IXJ6	2290270		GO_Central	GO_REF:0000033
Sirt3	Mouse	NAD+ binding	enables	IEA	InterPro:IPR003000	2290270		InterPro	GO_REF:0000002
Sirt3	Mouse	NAD-dependent protein lysine deacetylase activity	enables	IDA		2290270	PMID:16790548, PMID:26620563	UniProt	PMID:16790548\|PMID:26620563
Sirt3	Mouse	NAD-dependent protein lysine delactylase activity	enables	ISS	UniProtKB:Q9NTG7	2290270		UniProt	GO_REF:0000024
Sirt3	Mouse	protein binding	enables	IPI	UniProtKB:P27545\|UniProtKB:Q8C172\|UniProtKB:Q924Z4	2290270	PMID:26620563	UniProt	PMID:26620563
Sirt3	Mouse	protein binding	enables	IPI	UniProtKB:P47738	2290270	PMID:21720390	IntAct	PMID:21720390
Sirt3	Mouse	protein binding	enables	IPI	UniProtKB:Q8BKF1,UniProtKB:Q9WVH4	2290270	PMID:23283301	UniProt	PMID:23283301
Sirt3	Mouse	protein lysine deacetylase activity	enables	IDA		2290270	PMID:21858060	MGI	PMID:21858060
Sirt3	Mouse	sequence-specific DNA binding	enables	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	sequence-specific DNA binding	enables	IDA		2290270	PMID:23283301	UniProt	PMID:23283301
Sirt3	Mouse	zinc ion binding	enables	ISO	UniProtKB:Q9NTG7	2290270		GO_Central	GO_REF:0000119
Sirt3	Mouse	zinc ion binding	enables	ISS	UniProtKB:Q9NTG7	2290270		UniProt	GO_REF:0000024

Molecular Pathway Annotations Click to see Annotation Detail View

RGD Manual Annotations

Only show annotations with direct experimental evidence (0 objects hidden)

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	histone modification pathway		ISO	RGD:1318106	9104959		RGD
Sirt3	Mouse	Sirtuin mediated pathway		ISO	RGD:1318106	11100032		RGD

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

Object Symbol	Species	Term	Qualifier	Evidence	With	Reference	Notes	Source	Original Reference(s)
Sirt3	Mouse	abnormal cell physiology		IAGP		5509061		MGI	PMID:18794531
Sirt3	Mouse	abnormal cellular respiration		IAGP		5509061		MGI	PMID:18794531
Sirt3	Mouse	abnormal cytokine level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	abnormal enzyme/coenzyme level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	abnormal gait		IEA		5509061		MGI
Sirt3	Mouse	abnormal lipid homeostasis		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	decreased carbon dioxide production		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	decreased liver triglyceride level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	decreased oxygen consumption		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	hyperglycemia		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating alanine transaminase level		IEA		5509061		MGI
Sirt3	Mouse	increased circulating cholesterol level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating creatine kinase level		IEA		5509061		MGI
Sirt3	Mouse	increased circulating insulin level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating interferon-gamma level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating interleukin-10 level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating interleukin-12 level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating interleukin-6 level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating LDL cholesterol level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating triglyceride level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating tumor necrosis factor level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased circulating VLDL cholesterol level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased insulin sensitivity		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased liver cholesterol level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased liver triglyceride level		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased susceptibility to diet-induced obesity		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	increased susceptibility to injury		IAGP		5509061		MGI	PMID:27681422
Sirt3	Mouse	increased systemic arterial systolic blood pressure		IEA		5509061		MGI
Sirt3	Mouse	increased total body fat amount		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	insulin resistance		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	liver fibrosis		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	liver inflammation		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	macrovesicular hepatic steatosis		IAGP		5509061		MGI	PMID:21856199
Sirt3	Mouse	no abnormal phenotype detected		IAGP		5509061		MGI	PMID:17923681
Sirt3	Mouse	vertebral fusion		IEA		5509061		MGI

Disease Annotations Click to see Annotation Detail View

abdominal obesity-metabolic syndrome (IAGP)

Alzheimer's disease (IEP)

Beckwith-Wiedemann syndrome (ISO)

congestive heart failure (ISO)

drug-induced hearing loss (ISO)

gestational diabetes (ISO)

immunodeficiency 39 (ISO)

metabolic dysfunction-associated steatotic liver disease (ISO)

Mouth Neoplasms (ISO)

myocardial infarction (ISO)

obesity (ISO)

prediabetes syndrome (ISO)

Presbycusis (ISO)

squamous cell carcinoma (ISO)

type 2 diabetes mellitus (ISO)

Gene-Chemical Interaction Annotations Click to see Annotation Detail View

(+)-schisandrin B (ISO)

(-)-epigallocatechin 3-gallate (EXP)

(1->4)-beta-D-glucan (EXP)

(R)-carnitine (EXP)

(R)-lipoic acid (EXP,ISO)

1,1,1-trichloro-2,2-bis(4-hydroxyphenyl)ethane (EXP)

1,1-dichloroethene (EXP)

1,2-dimethylhydrazine (EXP)

1,3,7,9-tetramethyluric acid (ISO)

17alpha-ethynylestradiol (EXP,ISO)

17beta-estradiol (EXP,ISO)

2,3,7,8-tetrachlorodibenzodioxine (EXP,ISO)

2,4-dinitrotoluene (ISO)

3,5-diethoxycarbonyl-1,4-dihydrocollidine (EXP)

3-chloropropane-1,2-diol (EXP)

4,4'-sulfonyldiphenol (EXP)

4-hydroxynon-2-enal (ISO)

6-chloro-2,3,4,9-tetrahydro-1H-carbazole-1-carboxamide (ISO)

6-propyl-2-thiouracil (ISO)

8-Br-cAMP (EXP)

ADP (EXP)

aldehydo-D-glucose (EXP,ISO)

alpha-mangostin (EXP,ISO)

amitrole (ISO)

antimycin A (ISO)

arsenous acid (ISO)

ATP (EXP)

atrazine (ISO)

benzo[a]pyrene (EXP,ISO)

benzo[a]pyrene diol epoxide I (ISO)

berberine (ISO)

beta-lapachone (ISO)

bis(2-ethylhexyl) phthalate (EXP)

bisphenol A (EXP,ISO)

Butylbenzyl phthalate (EXP,ISO)

cadmium dichloride (ISO)

caffeine (ISO)

carbon nanotube (EXP)

CGS-21680 (ISO)

chloroquine (ISO)

choline (EXP)

chromium(6+) (ISO)

cisplatin (EXP,ISO)

copper(II) sulfate (ISO)

curcumin (ISO)

cyclophosphamide (EXP)

D-glucose (EXP,ISO)

deguelin (ISO)

diarsenic trioxide (ISO)

diazinon (ISO)

Dibutyl phosphate (ISO)

dibutyl phthalate (ISO)

diethylstilbestrol (EXP)

diisononyl phthalate (ISO)

Diosbulbin B (EXP)

doxorubicin (ISO)

estriol (EXP)

ethanol (EXP,ISO)

flutamide (ISO)

folic acid (EXP)

formononetin (ISO)

gemcitabine (EXP)

gentamycin (ISO)

glucose (EXP,ISO)

GSK-J4 (ISO)

hesperetin (ISO)

hexadecanoic acid (ISO)

Honokiol (ISO)

hydrogen peroxide (ISO)

hydrogen sulfide (ISO)

hydroquinone (ISO)

icariin (ISO)

L-methionine (EXP)

lead diacetate (EXP)

linagliptin (ISO)

linalool (ISO)

lipoic acid (EXP,ISO)

lipopolysaccharide (ISO)

lycopene (EXP)

mancozeb (ISO)

maneb (ISO)

melatonin (EXP,ISO)

metformin (EXP,ISO)

methimazole (ISO)

methotrexate (EXP)

metiram (ISO)

mono(2-ethylhexyl) phthalate (EXP)

monocrotaline (ISO)

N-acetyl-L-cysteine (ISO)

N-methyl-4-phenylpyridinium (EXP,ISO)

nebivolol (EXP)

nicotinamide (ISO)

nitrates (EXP)

okadaic acid (ISO)

paracetamol (EXP,ISO)

paraquat (ISO)

perfluorooctane-1-sulfonic acid (EXP,ISO)

perfluorooctanoic acid (EXP)

pregnenolone 16alpha-carbonitrile (ISO)

propiconazole (EXP)

propionic acid (ISO)

reactive oxygen species (ISO)

resveratrol (EXP,ISO)

rotenone (ISO)

salvianolic acid B (EXP)

sodium arsenite (EXP,ISO)

sodium fluoride (EXP,ISO)

sodium sulfide (anhydrous) (ISO)

Soman (ISO)

stavudine (ISO)

sulfadimethoxine (ISO)

tenofovir disoproxil fumarate (ISO)

tert-butyl hydroperoxide (ISO)

tetrachloromethane (EXP,ISO)

thapsigargin (ISO)

thioacetamide (ISO)

thiram (ISO)

titanium dioxide (EXP)

trichloroethene (ISO)

trilobatin (ISO)

triptonide (EXP)

tris(2-chloroethyl) phosphate (ISO)

tunicamycin (ISO)

urethane (ISO)

valdecoxib (ISO)

valproic acid (ISO)

vancomycin (EXP)

vosaroxin (ISO)

zidovudine (ISO)

Gene Ontology Annotations Click to see Annotation Detail View

Biological Process

aerobic respiration (ISO,ISS)

negative regulation of ERK1 and ERK2 cascade (ISO)

negative regulation of peptidyl-lysine acetylation (IDA,IMP)

negative regulation of reactive oxygen species metabolic process (ISO)

peptidyl-lysine deacetylation (IDA,ISO,ISS)

positive regulation of catalase activity (ISO)

positive regulation of ceramide biosynthetic process (IDA)

positive regulation of insulin secretion (ISO)

positive regulation of mitochondrial transcription (IMP)

positive regulation of oxidative phosphorylation (ISO)

positive regulation of superoxide dismutase activity (ISO)

protein deacetylation (IMP,ISO,ISS)

tricarboxylic acid cycle (IMP)

Cellular Component

membrane (IDA)

mitochondrial inner membrane (IDA)

mitochondrial matrix (IDA,ISO)

mitochondrion (HDA,IDA,ISO,ISS)

nucleus (IBA)

protein-containing complex (IDA,ISO)

Molecular Function

enzyme binding (ISO)

histone deacetylase activity, NAD-dependent (IBA)

histone H3K14 deacetylase activity, NAD-dependent (IEA)

histone H3K18 deacetylase activity, NAD-dependent (IEA)

histone H3K4 deacetylase activity, NAD-dependent (IEA)

histone H3K56 deacetylase activity, NAD-dependent (IEA)

histone H3K9 deacetylase activity, NAD-dependent (IEA)

histone H4K16 deacetylase activity, NAD-dependent (IEA)

NAD+ binding (IBA,IEA)

NAD-dependent protein lysine deacetylase activity (IDA)

NAD-dependent protein lysine delactylase activity (ISS)

protein binding (IPI)

protein lysine deacetylase activity (IDA)

sequence-specific DNA binding (IDA,ISO)

zinc ion binding (ISO,ISS)

Molecular Pathway Annotations Click to see Annotation Detail View

histone modification pathway (ISO)

Sirtuin mediated pathway (ISO)

Phenotype Annotations Click to see Annotation Detail View

Mammalian Phenotype

abnormal cell physiology (IAGP)

abnormal cellular respiration (IAGP)

abnormal cytokine level (IAGP)

abnormal enzyme/coenzyme level (IAGP)

abnormal gait (IEA)

abnormal lipid homeostasis (IAGP)

decreased carbon dioxide production (IAGP)

decreased liver triglyceride level (IAGP)

decreased oxygen consumption (IAGP)

hyperglycemia (IAGP)

increased circulating alanine transaminase level (IEA)

increased circulating cholesterol level (IAGP)

increased circulating creatine kinase level (IEA)

increased circulating insulin level (IAGP)

increased circulating interferon-gamma level (IAGP)

increased circulating interleukin-10 level (IAGP)

increased circulating interleukin-12 level (IAGP)

increased circulating interleukin-6 level (IAGP)

increased circulating LDL cholesterol level (IAGP)

increased circulating triglyceride level (IAGP)

increased circulating tumor necrosis factor level (IAGP)

increased circulating VLDL cholesterol level (IAGP)

increased insulin sensitivity (IAGP)

increased liver cholesterol level (IAGP)

increased liver triglyceride level (IAGP)

increased susceptibility to diet-induced obesity (IAGP)

increased susceptibility to injury (IAGP)

increased systemic arterial systolic blood pressure (IEA)

increased total body fat amount (IAGP)

insulin resistance (IAGP)

liver fibrosis (IAGP)

liver inflammation (IAGP)

macrovesicular hepatic steatosis (IAGP)

no abnormal phenotype detected (IAGP)

vertebral fusion (IEA)

References

References - curated

#	Reference Title	Reference Citation
1.	Maternal obesity during gestation impairs fatty acid oxidation and mitochondrial SIRT3 expression in rat offspring at weaning.	Borengasser SJ, etal., PLoS One. 2011;6(8):e24068. doi: 10.1371/journal.pone.0024068. Epub 2011 Aug 25.
2.	Sirtuin 3 regulates mouse pancreatic beta cell function and is suppressed in pancreatic islets isolated from human type 2 diabetic patients.	Caton PW, etal., Diabetologia. 2013 May;56(5):1068-77. doi: 10.1007/s00125-013-2851-y. Epub 2013 Feb 9.
3.	Non-histone lysine acetylated proteins in heart failure.	Grillon JM, etal., Biochim Biophys Acta. 2012 Apr;1822(4):607-14. doi: 10.1016/j.bbadis.2011.11.016. Epub 2011 Dec 3.
4.	Aerobic interval training protects against myocardial infarction-induced oxidative injury by enhancing antioxidase system and mitochondrial biosynthesis.	Jiang HK, etal., Clin Exp Pharmacol Physiol. 2014 Mar;41(3):192-201. doi: 10.1111/1440-1681.12211.
5.	Functional annotation of a full-length mouse cDNA collection.	Kawai J, etal., Nature. 2001 Feb 8;409(6821):685-90.
6.	MGDs mouse GO annotations	MGD data from the GO Consortium
7.	MGD IEA	MGD IEA
8.	Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs.	Okazaki Y, etal., Nature. 2002 Dec 5;420(6915):563-73.
9.	Physical and functional HAT/HDAC interplay regulates protein acetylation balance.	Peserico A and Simone C, J Biomed Biotechnol. 2011;2011:371832. doi: 10.1155/2011/371832. Epub 2010 Dec 5.
10.	Pre-diabetes alters testicular PGC1-alpha/SIRT3 axis modulating mitochondrial bioenergetics and oxidative stress.	Rato L, etal., Biochim Biophys Acta. 2014 Mar;1837(3):335-44. doi: 10.1016/j.bbabio.2013.12.008. Epub 2013 Dec 20.
11.	Mouse MP Annotation Import Pipeline	RGD automated import pipeline
12.	ClinVar Automated Import and Annotation Pipeline	RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
13.	Data Import for Chemical-Gene Interactions	RGD automated import pipeline for gene-chemical interactions
14.	Lipoic acid improves mitochondrial function in nonalcoholic steatosis through the stimulation of sirtuin 1 and sirtuin 3.	Valdecantos MP, etal., Obesity (Silver Spring). 2012 Oct;20(10):1974-83. doi: 10.1038/oby.2012.32. Epub 2012 Feb 13.
15.	NAD(+) in aging, metabolism, and neurodegeneration.	Verdin E Science. 2015 Dec 4;350(6265):1208-13. doi: 10.1126/science.aac4854.
16.	CNS SIRT3 expression is altered by reactive oxygen species and in Alzheimer's disease.	Weir HJ, etal., PLoS One. 2012;7(11):e48225. doi: 10.1371/journal.pone.0048225. Epub 2012 Nov 6.
17.	Age-Related Decrease in the Mitochondrial Sirtuin Deacetylase Sirt3 Expression Associated with ROS Accumulation in the Auditory Cortex of the Mimetic Aging Rat Model.	Zeng L, etal., PLoS One. 2014 Feb 4;9(2):e88019. doi: 10.1371/journal.pone.0088019. eCollection 2014.

Additional References at PubMed

PMID:3444409	PMID:8889548	PMID:10349636	PMID:11042159	PMID:11056054	PMID:11076861	PMID:12477932	PMID:14610273	PMID:15489334	PMID:15653680	PMID:16141072	PMID:16141073
PMID:16602821	PMID:16790548	PMID:17923681	PMID:18054327	PMID:18363549	PMID:18614015	PMID:18710944	PMID:18719589	PMID:18794531	PMID:18799693	PMID:18824292	PMID:19241369
PMID:19333382	PMID:19410549	PMID:19652361	PMID:19940131	PMID:20000467	PMID:20042612	PMID:20059953	PMID:20129246	PMID:20157566	PMID:20203611	PMID:20235147	PMID:20644252
PMID:20661474	PMID:20677216	PMID:21044047	PMID:21094524	PMID:21109197	PMID:21109198	PMID:21165558	PMID:21172655	PMID:21212461	PMID:21255725	PMID:21390294	PMID:21397863
PMID:21449565	PMID:21454513	PMID:21664458	PMID:21677750	PMID:21720390	PMID:21840382	PMID:21856199	PMID:21858060	PMID:21873205	PMID:21873635	PMID:22394676	PMID:22416140
PMID:22645641	PMID:22956852	PMID:23201123	PMID:23236377	PMID:23283301	PMID:23375372	PMID:23396452	PMID:23508103	PMID:23576753	PMID:23643077	PMID:23767918	PMID:23835326
PMID:24039710	PMID:24047466	PMID:24051248	PMID:24073283	PMID:24121500	PMID:24194600	PMID:24252090	PMID:24363305	PMID:24370889	PMID:24454908	PMID:24486017	PMID:24748594
PMID:24909164	PMID:24966184	PMID:25090966	PMID:25192254	PMID:25284742	PMID:25384422	PMID:25404738	PMID:25470550	PMID:25489948	PMID:25505263	PMID:25555707	PMID:25566066
PMID:25607838	PMID:25681462	PMID:25748450	PMID:25757953	PMID:25759382	PMID:25782072	PMID:25790176	PMID:25811481	PMID:25830335	PMID:25863253	PMID:25871830	PMID:25948682
PMID:25962702	PMID:26121691	PMID:26319214	PMID:26358839	PMID:26403315	PMID:26464666	PMID:26472659	PMID:26523980	PMID:26524632	PMID:26620563	PMID:26667039	PMID:26698917
PMID:26767982	PMID:26769382	PMID:26789108	PMID:26868537	PMID:26873966	PMID:26928655	PMID:27000941	PMID:27021965	PMID:27040510	PMID:27047337	PMID:27052737	PMID:27128560
PMID:27295248	PMID:27304511	PMID:27423420	PMID:27540894	PMID:27613967	PMID:27620507	PMID:27626380	PMID:27681422	PMID:27794418	PMID:27815257	PMID:27880725	PMID:27881304
PMID:28236057	PMID:28255277	PMID:28258190	PMID:28286268	PMID:28296029	PMID:28369333	PMID:28375738	PMID:28396567	PMID:28437863	PMID:28449871	PMID:28465484	PMID:28480597
PMID:28500761	PMID:28579116	PMID:28584055	PMID:28603486	PMID:28662362	PMID:28673962	PMID:28684630	PMID:28687409	PMID:28724806	PMID:28808064	PMID:28862956	PMID:28878358
PMID:28911171	PMID:28914882	PMID:28935506	PMID:29031725	PMID:29076061	PMID:29130578	PMID:29151261	PMID:29198988	PMID:29236713	PMID:29277324	PMID:29302794	PMID:29330215
PMID:29363727	PMID:29444200	PMID:29466723	PMID:29574628	PMID:29589261	PMID:29634313	PMID:29650970	PMID:29654651	PMID:29674007	PMID:29689547	PMID:29721150	PMID:29765980
PMID:29777578	PMID:29915018	PMID:29958828	PMID:29972782	PMID:30056271	PMID:30171880	PMID:30219671	PMID:30250024	PMID:30362958	PMID:30368983	PMID:30389773	PMID:30411306
PMID:30445987	PMID:30487750	PMID:30510203	PMID:30525304	PMID:30545041	PMID:30584213	PMID:30626741	PMID:30726738	PMID:30735837	PMID:30774023	PMID:30794763	PMID:30801823
PMID:30846716	PMID:30848932	PMID:30849386	PMID:30970248	PMID:30973865	PMID:31015456	PMID:31060926	PMID:31085231	PMID:31160717	PMID:31185214	PMID:31201798	PMID:31208274
PMID:31269804	PMID:31302001	PMID:31318577	PMID:31340681	PMID:31409767	PMID:31469588	PMID:31632409	PMID:31641228	PMID:31652451	PMID:31712596	PMID:31773668	PMID:31813822
PMID:31818974	PMID:31849939	PMID:31852393	PMID:31858519	PMID:31858862	PMID:31876685	PMID:31936019	PMID:31936371	PMID:31991048	PMID:32026628	PMID:32119761	PMID:32212196
PMID:32236798	PMID:32296036	PMID:32325033	PMID:32439965	PMID:32447338	PMID:32463172	PMID:32468895	PMID:32485218	PMID:32500353	PMID:32524313	PMID:32526680	PMID:32658908
PMID:32721927	PMID:32722183	PMID:32726464	PMID:32770173	PMID:32835604	PMID:32898015	PMID:32912335	PMID:32933152	PMID:32951306	PMID:33002579	PMID:33006225	PMID:33049518
PMID:33087457	PMID:33107080	PMID:33131100	PMID:33327751	PMID:33359008	PMID:33371209	PMID:33385630	PMID:33448325	PMID:33531400	PMID:33541361	PMID:33586458	PMID:33634989
PMID:33664465	PMID:33665656	PMID:33690226	PMID:33744652	PMID:33770326	PMID:33789208	PMID:33805532	PMID:33823364	PMID:33878033	PMID:33900547	PMID:33924115	PMID:33973685
PMID:34119577	PMID:34122726	PMID:34180125	PMID:34181898	PMID:34202229	PMID:34216536	PMID:34272364	PMID:34370691	PMID:34386777	PMID:34405591	PMID:34478012	PMID:34518519
PMID:34571997	PMID:34591326	PMID:34597611	PMID:34606850	PMID:34624325	PMID:34630854	PMID:34644302	PMID:34668131	PMID:34687443	PMID:34695364	PMID:34780879	PMID:34807408
PMID:34849375	PMID:34880332	PMID:35011652	PMID:35100024	PMID:35167498	PMID:35182747	PMID:35234263	PMID:35367825	PMID:35398277	PMID:35406095	PMID:35417703	PMID:35418250
PMID:35624490	PMID:35650472	PMID:35749057	PMID:35793583	PMID:35798229	PMID:35821123	PMID:35902030	PMID:35955472	PMID:36092157	PMID:36100663	PMID:36125675	PMID:36130801
PMID:36134579	PMID:36151131	PMID:36153410	PMID:36199173	PMID:36211825	PMID:36291179	PMID:36306990	PMID:36336229	PMID:36396721	PMID:36433732	PMID:36435202	PMID:36446868
PMID:36449070	PMID:36460774	PMID:36537765	PMID:36574062	PMID:36657499	PMID:36692509	PMID:36738799	PMID:36739437	PMID:36759193	PMID:36786945	PMID:36804441	PMID:36815302
PMID:36863620	PMID:36894333	PMID:36905127	PMID:36906951	PMID:36966803	PMID:37058075	PMID:37068637	PMID:37146925	PMID:37268048	PMID:37275851	PMID:37348684	PMID:37392543
PMID:37408261	PMID:37417912	PMID:37468929	PMID:37481555	PMID:37499855	PMID:37536502	PMID:37599829	PMID:37646156	PMID:37683629	PMID:37705748	PMID:37798514	PMID:37816025
PMID:37840428	PMID:37950995	PMID:38015645	PMID:38150004	PMID:38233193	PMID:38243371	PMID:38250153	PMID:38270316	PMID:38285890	PMID:38288355	PMID:38354290	PMID:38355793
PMID:38406970	PMID:38430040	PMID:38556109	PMID:38588611	PMID:38612678	PMID:38625851	PMID:38635631	PMID:38782252	PMID:38802337	PMID:39123294	PMID:39154858	PMID:39392752
PMID:39425510

Genomics

Comparative Map Data

Sirt3
(Mus musculus - house mouse)

Mouse Assembly	Chr	Position (strand)	Source	Genome Browsers
Mouse Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCm39	7	140,443,576 - 140,462,222 (-)	NCBI	GRCm39	GRCm39	mm39
GRCm39 Ensembl	7	140,443,579 - 140,462,222 (-)	Ensembl		GRCm39 Ensembl
GRCm38	7	140,863,663 - 140,882,309 (-)	NCBI	GRCm38	GRCm38	mm10	GRCm38
GRCm38.p6 Ensembl	7	140,863,666 - 140,882,309 (-)	Ensembl	GRCm38		mm10	GRCm38
MGSCv37	7	148,049,562 - 148,068,208 (-)	NCBI	GRCm37	MGSCv37	mm9	NCBIm37
MGSCv36	7	140,714,990 - 140,733,629 (-)	NCBI		MGSCv36	mm8
Celera	7	140,655,950 - 140,674,596 (-)	NCBI		Celera
Cytogenetic Map	7	F4- F5	NCBI
cM Map	7	86.07	NCBI

SIRT3
(Homo sapiens - human)

Human Assembly	Chr	Position (strand)	Source	Genome Browsers
Human Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCh38	11	215,030 - 236,931 (-)	NCBI	GRCh38	GRCh38	hg38	GRCh38
GRCh38.p14 Ensembl	11	215,030 - 236,931 (-)	Ensembl	GRCh38		hg38	GRCh38
GRCh37	11	215,030 - 236,931 (-)	NCBI	GRCh37	GRCh37	hg19	GRCh37
Build 36	11	205,030 - 226,362 (-)	NCBI	NCBI36	Build 36	hg18	NCBI36
Build 34	11	206,138 - 226,416	NCBI
Celera	11	322,773 - 343,832 (+)	NCBI		Celera
Cytogenetic Map	11	p15.5	NCBI
HuRef	11	35,047 - 56,030 (-)	NCBI		HuRef
CHM1_1	11	213,704 - 234,799 (-)	NCBI		CHM1_1
T2T-CHM13v2.0	11	256,228 - 277,937 (-)	NCBI		T2T-CHM13v2.0

Sirt3
(Rattus norvegicus - Norway rat)

Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
GRCr8	1	205,371,703 - 205,394,145 (-)	NCBI		GRCr8
mRatBN7.2	1	195,942,066 - 195,964,472 (-)	NCBI	mRatBN7.2	mRatBN7.2
mRatBN7.2 Ensembl	1	195,942,073 - 195,964,808 (-)	Ensembl		mRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx	1	204,294,536 - 204,318,293 (-)	NCBI	Rnor_SHR	UTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.0	1	211,421,447 - 211,445,196 (-)	NCBI	Rnor_SHRSP	UTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.0	1	204,095,300 - 204,119,047 (-)	NCBI	Rnor_WKY	UTH_Rnor_WKY_Bbb_1.0
Rnor_6.0	1	213,613,502 - 213,636,061 (-)	NCBI	Rnor6.0	Rnor_6.0	rn6	Rnor6.0
Rnor_6.0 Ensembl	1	213,613,513 - 213,635,546 (-)	Ensembl	Rnor6.0		rn6	Rnor6.0
Rnor_5.0	1	220,539,132 - 220,561,380 (-)	NCBI	Rnor5.0	Rnor_5.0	rn5	Rnor5.0
RGSC_v3.4	1	201,021,391 - 201,043,756 (-)	NCBI	RGSC3.4	RGSC_v3.4	rn4	RGSC3.4
RGSC_v3.1	1	201,172,601 - 201,193,816 (-)	NCBI
Celera	1	193,586,014 - 193,607,810 (-)	NCBI		Celera
Cytogenetic Map	1	q41	NCBI

Sirt3
(Chinchilla lanigera - long-tailed chinchilla)

Chinchilla Assembly	Chr	Position (strand)	Source	Genome Browsers
Chinchilla Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChiLan1.0 Ensembl	NW_004955476	11,794,951 - 11,826,237 (+)	Ensembl	ChiLan1.0
ChiLan1.0	NW_004955476	11,794,951 - 11,826,244 (+)	NCBI	ChiLan1.0	ChiLan1.0

SIRT3
(Pan paniscus - bonobo/pygmy chimpanzee)

Bonobo Assembly	Chr	Position (strand)	Source	Genome Browsers
Bonobo Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
NHGRI_mPanPan1-v2	9	2,582,959 - 2,605,626 (-)	NCBI		NHGRI_mPanPan1-v2
NHGRI_mPanPan1	11	1,737,925 - 1,761,366 (-)	NCBI		NHGRI_mPanPan1
Mhudiblu_PPA_v0	11	210,052 - 233,969 (-)	NCBI	Mhudiblu_PPA_v0	Mhudiblu_PPA_v0	panPan3
PanPan1.1	11	255,191 - 863,031 (-)	NCBI	panpan1.1	PanPan1.1	panPan2
PanPan1.1 Ensembl	11	255,191 - 278,732 (-)	Ensembl	panpan1.1		panPan2

SIRT3
(Canis lupus familiaris - dog)

Dog Assembly	Chr	Position (strand)	Source	Genome Browsers
Dog Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
CanFam3.1	18	25,369,183 - 25,388,126 (-)	NCBI	CanFam3.1	CanFam3.1	canFam3	CanFam3.1
CanFam3.1 Ensembl	18	25,369,382 - 25,388,118 (-)	Ensembl	CanFam3.1		canFam3	CanFam3.1
Dog10K_Boxer_Tasha	18	25,019,130 - 25,038,115 (-)	NCBI		Dog10K_Boxer_Tasha
ROS_Cfam_1.0	18	25,895,720 - 25,914,839 (-)	NCBI		ROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl	18	25,895,722 - 25,914,795 (-)	Ensembl		ROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1	18	25,463,734 - 25,482,834 (-)	NCBI		UMICH_Zoey_3.1
UNSW_CanFamBas_1.0	18	25,108,512 - 25,127,612 (-)	NCBI		UNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0	18	25,721,366 - 25,740,351 (-)	NCBI		UU_Cfam_GSD_1.0

Sirt3
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)

Squirrel Assembly	Chr	Position (strand)	Source	Genome Browsers
Squirrel Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HiC_Itri_2	NW_024404947	63,131 - 78,513 (-)	NCBI		HiC_Itri_2
SpeTri2.0 Ensembl	NW_004936888	63,546 - 77,950 (-)	Ensembl	SpeTri2.0	SpeTri2.0 Ensembl
SpeTri2.0	NW_004936888	63,131 - 78,536 (-)	NCBI	SpeTri2.0	SpeTri2.0		SpeTri2.0

SIRT3
(Sus scrofa - pig)

Pig Assembly	Chr	Position (strand)	Source	Genome Browsers
Pig Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
Sscrofa11.1 Ensembl	2	38,464 - 55,101 (-)	Ensembl	Sscrofa11.1		susScr11	Sscrofa11.1
Sscrofa11.1	2	38,465 - 55,074 (-)	NCBI	Sscrofa11.1	Sscrofa11.1	susScr11	Sscrofa11.1
Sscrofa10.2	2	162,169,820 - 162,186,214 (+)	NCBI	Sscrofa10.2	Sscrofa10.2	susScr3

SIRT3
(Chlorocebus sabaeus - green monkey)

Green Monkey Assembly	Chr	Position (strand)	Source	Genome Browsers
Green Monkey Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
ChlSab1.1	1	25,740 - 49,471 (-)	NCBI	ChlSab1.1	ChlSab1.1	chlSab2
ChlSab1.1 Ensembl	1	26,927 - 48,944 (-)	Ensembl	ChlSab1.1	ChlSab1.1 Ensembl	chlSab2
Vero_WHO_p1.0	NW_023666038	97,040,657 - 97,063,458 (-)	NCBI	Vero_WHO_p1.0	Vero_WHO_p1.0

Sirt3
(Heterocephalus glaber - naked mole-rat)

Naked Mole-Rat Assembly	Chr	Position (strand)	Source	Genome Browsers
Naked Mole-Rat Assembly	Chr	Position (strand)	Source	JBrowse	NCBI	UCSC	Ensembl
HetGla_female_1.0 Ensembl	NW_004624766	22,199,601 - 22,233,933 (+)	Ensembl	HetGla_female_1.0	HetGla_female_1.0 Ensembl	hetGla2
HetGla 1.0	NW_004624766	22,199,741 - 22,233,933 (+)	NCBI	HetGla_female_1.0	HetGla 1.0	hetGla2

Variants

Variants in Sirt3
975 total Variants

miRNA Target Status (No longer updated)

Predicted Target Of

	Summary Value
Count of predictions:	767
Count of miRNA genes:	432
Interacting mature miRNAs:	519
Transcripts:	ENSMUST00000026559, ENSMUST00000106048, ENSMUST00000137024, ENSMUST00000137710, ENSMUST00000147331
Prediction methods:	Miranda, Rnahybrid, Targetscan
Result types:	miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.

QTLs in Region (GRCm39)

The following QTLs overlap with this region.

RGD ID	Symbol	Name	LOD	P Value	Trait	Sub Trait	Chr	Start	Stop	Species
27226751	Femd5_m	femur midshaft diameter 5, 10 week (mouse)					7	53249748	143153737	Mouse
27095933	Ulnl3_m	ulna length 3, 5 week (mouse)					7	73149748	143153737	Mouse
11059562	Lmr21b_m	leishmaniasis resistance 21b (mouse)					7	110967235	144967336	Mouse
1302032	Alcp12_m	alcohol preference locus 12 (mouse)			Not determined		7	111166122	144995196	Mouse
1301590	Pbwg3_m	postnatal body weight growth 3 (mouse)			Not determined		7	127311241	144995196	Mouse
1300566	Sluc8_m	susceptibility to lung cancer 8 (mouse)			Not determined		7	127398151	144995196	Mouse
14700684	Civq1_m	cerebral infarct volume QTL 1 (mouse)					7	109707335	143707335	Mouse
1300670	Sluc19_m	susceptibility to lung cancer 19 (mouse)			Not determined		7	111166122	144995196	Mouse
14746988	Manh63_m	mandible shape 63 (mouse)					7	127735437	144995196	Mouse
14700687	Civq5_m	cerebral infarct volume QTL 5 (mouse)					7	109707335	143707335	Mouse
14700688	Civq6_m	cerebral infarct volume QTL 6 (mouse)					7	109707335	143707335	Mouse
12792978	Fbmd3_m	femoral bone mineral density 3, females only (mouse)					7	7050288	142367832	Mouse
4142444	Femwf5_m	femur work to failure 5 (mouse)			Not determined			112552248	144995196	Mouse
1301158	Eae4_m	susceptibility to experimental allergic encephalomyelitis 4 (mouse)			Not determined		7	19147398	141919804	Mouse
1300677	Bmd9_m	bone mineral density 9 (mouse)			Not determined		7	116634089	144995196	Mouse
1300747	Skts2_m	skin tumor susceptibility 2 (mouse)			Not determined		7	112922733	144995196	Mouse
1301898	Alcp14_m	alcohol preference locus 14 (mouse)			Not determined		7	111166122	144995196	Mouse
1357711	Adbg1_m	adult body growth 1 (mouse)			Not determined		7	118693381	144398314	Mouse
10402499	Lmr21_m	leishmaniasis resistance 21 (mouse)			Not determined		7	110967235	144967336	Mouse
1301773	Stheal7_m	soft tissue heal 7 (mouse)			Not determined		7	119132573	144995196	Mouse

Markers in Region

AI848213

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	140,863,885 - 140,864,003	UniSTS	GRCm38
MGSCv37	7	148,049,784 - 148,049,902	UniSTS	GRCm37
Celera	7	140,656,172 - 140,656,290	UniSTS
Cytogenetic Map	7	F4	UniSTS
Cytogenetic Map	7	F5	UniSTS
Whitehead/MRC_RH	7	1429.19	UniSTS

Sirt3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
MGSCv37	7	148,062,283 - 148,063,645	UniSTS	GRCm37
Celera	7	140,668,671 - 140,670,033	UniSTS
cM Map	7	86.07	UniSTS

Sirt3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
GRCm38	7	140,876,384 - 140,877,746	UniSTS	GRCm38
MGSCv37	7	148,062,283 - 148,063,645	UniSTS	GRCm37
Celera	7	140,668,671 - 140,670,033	UniSTS
Cytogenetic Map	7	F4	UniSTS
cM Map	7	86.07	UniSTS

Sirt3

Mouse Assembly	Chr	Position (strand)	Source	JBrowse
Cytogenetic Map	7	F4	UniSTS

Expression

RNA-SEQ Expression

Click on a value in the shaded box below the category label to view a detailed expression data table for that system.

Sequence

Nucleotide Sequences


RefSeq Transcripts	NM_001127351	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_001177804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	NM_022433	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006536222	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	XM_006536223	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
GenBank Nucleotide	AC107815	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF299338	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AF299339	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AH010003	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK075861	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK086910	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	AK165407	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BC025878	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	BF681854	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CB953804	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CH466531	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	CT010402	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	EU886466	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles
	FJ621493	(Get FASTA)	NCBI Sequence Viewer	Search GEO for Microarray Profiles

Ensembl Acc Id:

ENSMUST00000026559 ⟹ ENSMUSP00000026559

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,443,583 - 140,462,222 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,863,670 - 140,882,309 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000106048 ⟹ ENSMUSP00000101663

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,443,583 - 140,461,782 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,863,670 - 140,881,869 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000137024 ⟹ ENSMUSP00000114247

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,444,933 - 140,458,060 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,865,020 - 140,878,147 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000137710 ⟹ ENSMUSP00000115202

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,456,347 - 140,461,782 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,876,434 - 140,881,869 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000147331 ⟹ ENSMUSP00000121151

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,449,402 - 140,461,782 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,869,489 - 140,881,869 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000210296 ⟹ ENSMUSP00000147504

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,443,579 - 140,462,202 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,863,666 - 140,882,289 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000210398

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,460,987 - 140,462,209 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,881,074 - 140,882,296 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000210706

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,453,754 - 140,456,959 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,873,841 - 140,877,046 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000210974

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,455,583 - 140,461,740 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,875,670 - 140,881,827 (-)	Ensembl

Ensembl Acc Id:

ENSMUST00000211179 ⟹ ENSMUSP00000147716

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39 Ensembl	7	140,443,583 - 140,462,211 (-)	Ensembl
GRCm38.p6 Ensembl	7	140,863,670 - 140,882,298 (-)	Ensembl

RefSeq Acc Id:

NM_001127351 ⟹ NP_001120823

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	140,443,576 - 140,461,782 (-)	NCBI
GRCm38	7	140,863,663 - 140,881,869 (-)	NCBI
MGSCv37	7	148,049,562 - 148,068,208 (-)	RGD
Celera	7	140,655,950 - 140,674,596 (-)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

GGGGATTCGGATGGCGCTTGACCCTCTAGGCGCCGTCGTCCTGCAGAGCATCATGGCGCTAAGC
GGTCGACTGGCATTGGCCGCGCTCAGACTGTGGGGTCCGGGAGTGTTACAGGTGGGAGAAGGCC
CATATCCCTCTGTGTGGGAGCCTCAGGCGGCTTTGGAGGTGGAGGAAGCAGTGAGAAGAAGTTT
TCTCTGCAGGATGTAGCTGAGCTGCTTCGGACCAGAGCCTGCAGTAGGGTGGTGGTCATGGTGG
GGGCCGGCATCAGCACACCCAGTGGCATCCCGGACTTCAGATCCCCAGGGAGCGGCCTCTACAG
CAACCTTCAGCAGTATGACATCCCGTACCCTGAAGCCATCTTTGAACTTGGCTTTTTCTTTCAC
AACCCCAAGCCCTTTTTCATGTTGGCCAAGGAGCTGTACCCTGGGCACTACAGGCCCAATGTCA
CTCACTACTTCCTGAGGCTCCTCCACGACAAGGAGCTGCTTCTGCGGCTCTATACACAGAACAT
CGACGGGCTTGAGAGAGCATCTGGGATCCCTGCCTCAAAGCTGGTTGAAGCCCACGGGACCTTT
GTAACAGCTACATGCACGGTCTGTCGAAGGTCCTTCCCAGGGGAAGACATATGGGCTGATGTGA
TGGCGGACAGGGTGCCCCGCTGCCCTGTCTGTACTGGCGTTGTGAAACCCGACATTGTGTTCTT
TGGGGAGCAGCTGCCTGCAAGGTTCCTACTCCATATGGCTGACTTCGCTTTGGCAGATCTGCTA
CTCATTCTTGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGTCTGAAGCAGTACAGAAAT
CAGTGCCCCGACTGCTCATCAATCGAGACTTGGTGGGGCCGTTCGTTCTGAGTCCTCGAAGGAA
AGATGTGGTCCAGCTAGGGGATGTAGTTCATGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGG
ACACAAGAACTGCTGGATCTTATGCAGCGGGAACGTGGCAAGCTGGATGGACAGGACAGATAAG
ACTATGGCTTCTTCACCTGGGGAAGTCACACAGCAGATCATCCTATGTCCAGCAAGACTTCATG
CCTGAAGACAGCTCCAACACGTTTACAAACATGAACCAGACCACAACATGTGGCCTGGACAGTG
GTCCTCCGAGGCTGCCTTTGGAAAGGCTGACCAGGGATGTCTACCCTTGGGGCCCCTCCATGTG
TGCGCCCTGTCCACCTCATCACTGCTGAAGGTGTAGTGCAGGTGCTGCTTTCTGCAGCGGCCCT
TAAGTTATCACGAGGGCAGCACAGCACGCCCGTCGCCAGGCAGGCGATGCACTAGGGCAATCTA
GCATGTTGATCGGTAAAGTGGCATCTTTAACTACAACATCATTTCTTGCATGAAATAAACTTAG
TATAAAAACTTGGCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_001177804 ⟹ NP_001171275

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	140,443,576 - 140,461,782 (-)	NCBI
GRCm38	7	140,863,663 - 140,881,869 (-)	NCBI
MGSCv37	7	148,049,562 - 148,068,208 (-)	RGD
Celera	7	140,655,950 - 140,674,596 (-)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

GGGGATTCGGATGGCGCTTGACCCTCTAGGCGCCGTCGTCCTGCAGAGCATCATGGCGCTAAGC
GGTCGACTGGCATTGGCCGCGCTCAGACTGTGGGGTCCGGGAGGTGGGAGAAGGCCCATATCCC
TCTGTGTGGGAGCCTCAGGCGGCTTTGGAGGTGGAGGAAGCAGTGAGAAGAAGTTTTCTCTGCA
GGATGTAGCTGAGCTGCTTCGGACCAGAGCCTGCAGTAGGGTGGTGGTCATGGTGGGGGCCGGC
ATCAGCACACCCAGTGGCATCCCGGACTTCAGATCCCCAGGGAGCGGCCTCTACAGCAACCTTC
AGCAGTATGACATCCCGTACCCTGAAGCCATCTTTGAACTTGGCTTTTTCTTTCACAACCCCAA
GCCCTTTTTCATGTTGGCCAAGGAGCTGTACCCTGGGCACTACAGGCCCAATGTCACTCACTAC
TTCCTGAGGCTCCTCCACGACAAGGAGCTGCTTCTGCGGCTCTATACACAGAACATCGACGGGC
TTGAGAGAGCATCTGGGATCCCTGCCTCAAAGCTGGTTGAAGCCCACGGGACCTTTGTAACAGC
TACATGCACGGTCTGTCGAAGGTCCTTCCCAGGGGAAGACATATGGGCTGATGTGATGGCGGAC
AGGGTGCCCCGCTGCCCTGTCTGTACTGGCGTTGTGAAACCCGACATTGTGTTCTTTGGGGAGC
AGCTGCCTGCAAGGTTCCTACTCCATATGGCTGACTTCGCTTTGGCAGATCTGCTACTCATTCT
TGGGACCTCCCTGGAGGTGGAGCCTTTTGCCAGCTTGTCTGAAGCAGTACAGAAATCAGTGCCC
CGACTGCTCATCAATCGAGACTTGGTGGGGCCGTTCGTTCTGAGTCCTCGAAGGAAAGATGTGG
TCCAGCTAGGGGATGTAGTTCATGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGGACACAAGA
ACTGCTGGATCTTATGCAGCGGGAACGTGGCAAGCTGGATGGACAGGACAGATAAGACTATGGC
TTCTTCACCTGGGGAAGTCACACAGCAGATCATCCTATGTCCAGCAAGACTTCATGCCTGAAGA
CAGCTCCAACACGTTTACAAACATGAACCAGACCACAACATGTGGCCTGGACAGTGGTCCTCCG
AGGCTGCCTTTGGAAAGGCTGACCAGGGATGTCTACCCTTGGGGCCCCTCCATGTGTGCGCCCT
GTCCACCTCATCACTGCTGAAGGTGTAGTGCAGGTGCTGCTTTCTGCAGCGGCCCTTAAGTTAT
CACGAGGGCAGCACAGCACGCCCGTCGCCAGGCAGGCGATGCACTAGGGCAATCTAGCATGTTG
ATCGGTAAAGTGGCATCTTTAACTACAACATCATTTCTTGCATGAAATAAACTTAGTATAAAAA
CTTGGCAAAAAAAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

NM_022433 ⟹ NP_071878

RefSeq Status:

VALIDATED

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	140,443,576 - 140,462,222 (-)	NCBI
GRCm38	7	140,863,663 - 140,882,309 (-)	ENTREZGENE
MGSCv37	7	148,049,562 - 148,068,208 (-)	RGD
Celera	7	140,655,950 - 140,674,596 (-)	RGD
cM Map	7		ENTREZGENE

Sequence:

show sequence

ACTTCCGCTAAACTTCTCCCGGGTTTCTGGCCCTGCCCTTGAGGCATTAAAGAGTAGAGGTGCC
TGGGGACAGCTAGCCACTGACTGGTCACGTAGCCTCAAGCCTGCAGACTTGGGTCCTCTGAAAC
CGGATGGCGTTTGGCGAGGACTAGTGTTACAGGTGGGAGAAGGCCCATATCCCTCTGTGTGGGA
GCCTCAGGCGGCTTTGGAGGTGGAGGAAGCAGTGAGAAGAAGTTTTCTCTGCAGGATGTAGCTG
AGCTGCTTCGGACCAGAGCCTGCAGTAGGGTGGTGGTCATGGTGGGGGCCGGCATCAGCACACC
CAGTGGCATCCCGGACTTCAGATCCCCAGGGAGCGGCCTCTACAGCAACCTTCAGCAGTATGAC
ATCCCGTACCCTGAAGCCATCTTTGAACTTGGCTTTTTCTTTCACAACCCCAAGCCCTTTTTCA
TGTTGGCCAAGGAGCTGTACCCTGGGCACTACAGGCCCAATGTCACTCACTACTTCCTGAGGCT
CCTCCACGACAAGGAGCTGCTTCTGCGGCTCTATACACAGAACATCGACGGGCTTGAGAGAGCA
TCTGGGATCCCTGCCTCAAAGCTGGTTGAAGCCCACGGGACCTTTGTAACAGCTACATGCACGG
TCTGTCGAAGGTCCTTCCCAGGGGAAGACATATGGGCTGATGTGATGGCGGACAGGGTGCCCCG
CTGCCCTGTCTGTACTGGCGTTGTGAAACCCGACATTGTGTTCTTTGGGGAGCAGCTGCCTGCA
AGGTTCCTACTCCATATGGCTGACTTCGCTTTGGCAGATCTGCTACTCATTCTTGGGACCTCCC
TGGAGGTGGAGCCTTTTGCCAGCTTGTCTGAAGCAGTACAGAAATCAGTGCCCCGACTGCTCAT
CAATCGAGACTTGGTGGGGCCGTTCGTTCTGAGTCCTCGAAGGAAAGATGTGGTCCAGCTAGGG
GATGTAGTTCATGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGGACACAAGAACTGCTGGATC
TTATGCAGCGGGAACGTGGCAAGCTGGATGGACAGGACAGATAAGACTATGGCTTCTTCACCTG
GGGAAGTCACACAGCAGATCATCCTATGTCCAGCAAGACTTCATGCCTGAAGACAGCTCCAACA
CGTTTACAAACATGAACCAGACCACAACATGTGGCCTGGACAGTGGTCCTCCGAGGCTGCCTTT
GGAAAGGCTGACCAGGGATGTCTACCCTTGGGGCCCCTCCATGTGTGCGCCCTGTCCACCTCAT
CACTGCTGAAGGTGTAGTGCAGGTGCTGCTTTCTGCAGCGGCCCTTAAGTTATCACGAGGGCAG
CACAGCACGCCCGTCGCCAGGCAGGCGATGCACTAGGGCAATCTAGCATGTTGATCGGTAAAGT
GGCATCTTTAACTACAACATCATTTCTTGCATGAAATAAACTTAGTATAAAAACTTGGCAAAAA
AAAAAAAAAAAA

hide sequence

RefSeq Acc Id:

XM_006536222 ⟹ XP_006536285

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	140,443,576 - 140,461,808 (-)	NCBI
GRCm38	7	140,863,663 - 140,881,898 (-)	NCBI

Sequence:

show sequence

GAGGGCGGGGCTTGGCTCACGGGGGCGGGGATTCGGATGGCGCTTGACCCTCTAGGCGCCGTCG
TCCTGCAGAGCATCATGGCGCTAAGCGGTCGACTGGCATTGGCCGCGCTCAGACTGTGGGGTCC
GGGAGGTGGGAGAAGGCCCATATCCCTCTGTGTGGGAGCCTCAGGCGGCTTTGGAGGTGGAGGA
AGCAGTGAGAAGAAGTTTTCTCTGCAGGATGTAGCTGAGCTGCTTCGGACCAGAGCCTGCAGTA
GGGTGGTGGTCATGGTGGGGGCCGGCATCAGCACACCCAGTGGCATCCCGGACTTCAGATCCCC
AGGGAGCGGCCTCTACAGCAACCTTCAGCAGTATGACATCCCGTACCCTGAAGCCATCTTTGAA
CTTGGCTTTTTCTTTCACAACCCCAAGCCCTTTTTCATGTTGGCCAAGGAGCTGTACCCTGGGC
ACTACAGGCCCAATGTCACTCACTACTTCCTGAGGCTCCTCCACGACAAGGAGCTGCTTCTGCG
GCTCTATACACAGAACATCGACGGGCTTGAGAGAGCATCTGGGATCCCTGCCTCAAAGCTGGTT
GAAGCCCACGGGACCTTTGTAACAGCTACATGCACGGTCTGTCGAAGGTCCTTCCCAGGGGAAG
ACATATGGGTGGAGCCTTTTGCCAGCTTGTCTGAAGCAGTACAGAAATCAGTGCCCCGACTGCT
CATCAATCGAGACTTGGTGGGGCCGTTCGTTCTGAGTCCTCGAAGGAAAGATGTGGTCCAGCTA
GGGGATGTAGTTCATGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGGACACAAGAACTGCTGG
ATCTTATGCAGCGGGAACGTGGCAAGCTGGATGGACAGGACAGATAAGACTATGGCTTCTTCAC
CTGGGGAAGTCACACAGCAGATCATCCTATGTCCAGCAAGACTTCATGCCTGAAGACAGCTCCA
ACACGTTTACAAACATGAACCAGACCACAACATGTGGCCTGGACAGTGGTCCTCCGAGGCTGCC
TTTGGAAAGGCTGACCAGGGATGTCTACCCTTGGGGCCCCTCCATGTGTGCGCCCTGTCCACCT
CATCACTGCTGAAGGTGTAGTGCAGGTGCTGCTTTCTGCAGCGGCCCTTAAGTTATCACGAGGG
CAGCACAGCACGCCCGTCGCCAGGCAGGCGATGCACTAGGGCAATCTAGCATGTTGATCGGTAA
AGTGGCATCTTTAACTACAACATCATTTCTTGCATGAAATAAACTTAGTATAAAAACTTGGCA

hide sequence

RefSeq Acc Id:

XM_006536223 ⟹ XP_006536286

Type:

CODING

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm39	7	140,443,576 - 140,461,795 (-)	NCBI
GRCm38	7	140,863,663 - 140,881,877 (-)	NCBI

Sequence:

show sequence

GGCTCACGGGGGCGGGGATTCGGATGGCGCTTGACCCTCTAGGCGCCGTCGTCCTGCAGAGCAT
CATGGCGCTAAGCGGTCGACTGGCATTGGCCGCGCTCAGACTGTGGGGTCCGGGAGTGTTACAG
GTGGGAGAAGGCCCATATCCCTCTGTGTGGGAGCCTCAGGCGGCTTTGGAGGTGGAGGAAGCAG
TGAGAAGAAGTTTTCTCTGCAGGATGTAGCTGAGCTGCTTCGGACCAGAGCCTGCAGTAGGGTG
GTGGTCATGGTGGGGGCCGGCATCAGCACACCCAGTGGCATCCCGGACTTCAGATCCCCAGGGA
GCGGCCTCTACAGCAACCTTCAGCAGTATGACATCCCGTACCCTGAAGCCATCTTTGAACTTGG
CTTTTTCTTTCACAACCCCAAGCCCTTTTTCATGTTGGCCAAGGAGCTGTACCCTGGGCACTAC
AGGCCCAATGTCACTCACTACTTCCTGAGGCTCCTCCACGACAAGGAGCTGCTTCTGCGGCTCT
ATACACAGAACATCGACGGGCTTGAGAGAGCATCTGGGATCCCTGCCTCAAAGCTGGTTGAAGC
CCACGGGACCTTTGTAACAGCTACATGCACGGTCTGTCGAAGGTCCTTCCCAGGGGAAGACATA
TGGGTGGAGCCTTTTGCCAGCTTGTCTGAAGCAGTACAGAAATCAGTGCCCCGACTGCTCATCA
ATCGAGACTTGGTGGGGCCGTTCGTTCTGAGTCCTCGAAGGAAAGATGTGGTCCAGCTAGGGGA
TGTAGTTCATGGTGTGGAAAGGCTGGTGGACCTCCTGGGGTGGACACAAGAACTGCTGGATCTT
ATGCAGCGGGAACGTGGCAAGCTGGATGGACAGGACAGATAAGACTATGGCTTCTTCACCTGGG
GAAGTCACACAGCAGATCATCCTATGTCCAGCAAGACTTCATGCCTGAAGACAGCTCCAACACG
TTTACAAACATGAACCAGACCACAACATGTGGCCTGGACAGTGGTCCTCCGAGGCTGCCTTTGG
AAAGGCTGACCAGGGATGTCTACCCTTGGGGCCCCTCCATGTGTGCGCCCTGTCCACCTCATCA
CTGCTGAAGGTGTAGTGCAGGTGCTGCTTTCTGCAGCGGCCCTTAAGTTATCACGAGGGCAGCA
CAGCACGCCCGTCGCCAGGCAGGCGATGCACTAGGGCAATCTAGCATGTTGATCGGTAAAGTGG
CATCTTTAACTACAACATCATTTCTTGCATGAAATAAACTTAGTATAAAAACTTGGCA

hide sequence

Protein Sequences


Protein RefSeqs	NP_001120823	(Get FASTA)	NCBI Sequence Viewer
	NP_001171275	(Get FASTA)	NCBI Sequence Viewer
	NP_071878	(Get FASTA)	NCBI Sequence Viewer
	XP_006536285	(Get FASTA)	NCBI Sequence Viewer
	XP_006536286	(Get FASTA)	NCBI Sequence Viewer
GenBank Protein	AAG33227	(Get FASTA)	NCBI Sequence Viewer
	AAG39257	(Get FASTA)	NCBI Sequence Viewer
	AAG39258	(Get FASTA)	NCBI Sequence Viewer
	AAH25878	(Get FASTA)	NCBI Sequence Viewer
	ACJ70655	(Get FASTA)	NCBI Sequence Viewer
	ACM68947	(Get FASTA)	NCBI Sequence Viewer
	BAC36012	(Get FASTA)	NCBI Sequence Viewer
	CAJ18608	(Get FASTA)	NCBI Sequence Viewer
	EDL17961	(Get FASTA)	NCBI Sequence Viewer
	EDL17962	(Get FASTA)	NCBI Sequence Viewer
	EDL17963	(Get FASTA)	NCBI Sequence Viewer
Ensembl Protein	ENSMUSP00000026559
	ENSMUSP00000026559.8
	ENSMUSP00000101663
	ENSMUSP00000101663.4
	ENSMUSP00000114247
GenBank Protein	Q8R104	(Get FASTA)	NCBI Sequence Viewer

RefSeq Acc Id:	NP_071878 ⟸ NM_022433
- Peptide Label:	isoform 1
- UniProtKB:	Q4FJK3 (UniProtKB/TrEMBL), A0A1B0GRY5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRP NVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWA DVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAV QKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQRERGKLDGQD R hide sequence

RefSeq Acc Id:	NP_001120823 ⟸ NM_001127351
- Peptide Label:	isoform 1
- UniProtKB:	Q4FJK3 (UniProtKB/TrEMBL), A0A1B0GRY5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRP NVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWA DVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTSLEVEPFASLSEAV QKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQRERGKLDGQD R hide sequence

RefSeq Acc Id:	NP_001171275 ⟸ NM_001177804
- Peptide Label:	isoform 3
- UniProtKB:	C6ZII7 (UniProtKB/Swiss-Prot), B9W0A9 (UniProtKB/Swiss-Prot), Q9EPA8 (UniProtKB/Swiss-Prot), Q8R104 (UniProtKB/Swiss-Prot)
- Sequence:	show sequence MALDPLGAVVLQSIMALSGRLALAALRLWGPGGGRRPISLCVGASGGFGGGGSSEKKFSLQDVA ELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFF MLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCT VCRRSFPGEDIWADVMADRVPRCPVCTGVVKPDIVFFGEQLPARFLLHMADFALADLLLILGTS LEVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLD LMQRERGKLDGQDR hide sequence

RefSeq Acc Id:	XP_006536285 ⟸ XM_006536222
- Peptide Label:	isoform X1
- UniProtKB:	D3YTK6 (UniProtKB/TrEMBL)
- Sequence:	show sequence MALDPLGAVVLQSIMALSGRLALAALRLWGPGGGRRPISLCVGASGGFGGGGSSEKKFSLQDVA ELLRTRACSRVVVMVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFF MLAKELYPGHYRPNVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCT VCRRSFPGEDIWVEPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVD LLGWTQELLDLMQRERGKLDGQDR hide sequence

RefSeq Acc Id:	XP_006536286 ⟸ XM_006536223
- Peptide Label:	isoform X2
- UniProtKB:	D3YVQ5 (UniProtKB/TrEMBL)
- Sequence:	show sequence MVGAGISTPSGIPDFRSPGSGLYSNLQQYDIPYPEAIFELGFFFHNPKPFFMLAKELYPGHYRP NVTHYFLRLLHDKELLLRLYTQNIDGLERASGIPASKLVEAHGTFVTATCTVCRRSFPGEDIWV EPFASLSEAVQKSVPRLLINRDLVGPFVLSPRRKDVVQLGDVVHGVERLVDLLGWTQELLDLMQ RERGKLDGQDR hide sequence

Ensembl Acc Id:

ENSMUSP00000026559 ⟸ ENSMUST00000026559

Ensembl Acc Id:

ENSMUSP00000121151 ⟸ ENSMUST00000147331

Ensembl Acc Id:

ENSMUSP00000147716 ⟸ ENSMUST00000211179

Ensembl Acc Id:

ENSMUSP00000101663 ⟸ ENSMUST00000106048

Ensembl Acc Id:

ENSMUSP00000147504 ⟸ ENSMUST00000210296

Ensembl Acc Id:

ENSMUSP00000115202 ⟸ ENSMUST00000137710

Ensembl Acc Id:

ENSMUSP00000114247 ⟸ ENSMUST00000137024

Protein Domains

Deacetylase sirtuin-type

Protein Structures

Name	Modeler	Protein Id	AA Range	Protein Structure
AF-Q8R104-F1-model_v2	AlphaFold	Q8R104	1-334	view protein structure

Promoters

RGD ID:

8666033

Promoter ID:

EPDNEW_M11048

Type:

multiple initiation site

Name:

Sirt3_1

Description:

Mus musculus sirtuin 3 , transcript variant 1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11049

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	140,881,825 - 140,881,885	EPDNEW

RGD ID:

8666035

Promoter ID:

EPDNEW_M11049

Type:

initiation region

Name:

Sirt3_2

Description:

Mus musculus sirtuin 3 , transcript variant 1, mRNA.

SO ACC ID:

SO:0000170

Source:

EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)

Alternative Promoters:

null; see alsoEPDNEW_M11048

Experiment Methods:

Single-end sequencing.

Position:

Mouse Assembly	Chr	Position (strand)	Source
GRCm38	7	140,882,264 - 140,882,324	EPDNEW

RGD ID:

6842037

Promoter ID:

MM_KWN:53194

Type:

CpG-Island

SO ACC ID:

SO:0000170

Source:

MPROMDB

Tissues & Cell Lines:

3T3L1_Day0, 3T3L1_Day1, 3T3L1_Day3, 3T3L1_Day4, BoneMarrow_0Hour, BoneMarrow_4Hour, Brain, Kidney, MEF_B4, MEF_B6

Transcripts:

NM_001127351, NM_022433, OTTMUST00000056979, OTTMUST00000056980

Position:

Mouse Assembly	Chr	Position (strand)	Source
MGSCv36	7	148,067,671 - 148,068,202 (-)	MPROMDB

Additional Information

External Database Links

Database	Acc Id	Source(s)
AGR Gene	MGI:1927665	AgrOrtholog
Ensembl Genes	ENSMUSG00000025486	Ensembl, ENTREZGENE, UniProtKB/Swiss-Prot
Ensembl Transcript	ENSMUST00000026559	ENTREZGENE
	ENSMUST00000026559.14	UniProtKB/Swiss-Prot
	ENSMUST00000106048	ENTREZGENE
	ENSMUST00000106048.10	UniProtKB/Swiss-Prot
	ENSMUST00000137024	ENTREZGENE
Gene3D-CATH	3.30.1600.10	UniProtKB/Swiss-Prot
	TPP-binding domain	UniProtKB/Swiss-Prot
InterPro	DHS-like_NAD/FAD-binding_dom	UniProtKB/Swiss-Prot
	NAD-dep_sirtuin_deacylases	UniProtKB/Swiss-Prot
	Sirtuin	UniProtKB/Swiss-Prot
	Sirtuin_cat_small_dom_sf	UniProtKB/Swiss-Prot
	Sirtuin_class_I	UniProtKB/Swiss-Prot
	Ssirtuin_cat_dom	UniProtKB/Swiss-Prot
KEGG Report	mmu:64384	UniProtKB/Swiss-Prot
MGD	MGI:1927665	ENTREZGENE
NCBI Gene	64384	ENTREZGENE
PANTHER	NAD-DEPENDENT PROTEIN DEACETYLASE SIRTUIN-3, MITOCHONDRIAL	UniProtKB/Swiss-Prot
	NAD-DEPENDENT PROTEIN DEACYLASE SIRTUIN-5, MITOCHONDRIAL-RELATED	UniProtKB/Swiss-Prot
Pfam	SIR2	UniProtKB/Swiss-Prot
PhenoGen	Sirt3	PhenoGen
PIRSF	SIR2_euk	UniProtKB/Swiss-Prot
PROSITE	SIRTUIN	UniProtKB/Swiss-Prot
Superfamily-SCOP	SSF52467	UniProtKB/Swiss-Prot
UniProt	A0A1B0GRF7_MOUSE	UniProtKB/TrEMBL
	A0A1B0GRY5	ENTREZGENE, UniProtKB/TrEMBL
	B9W0A9	ENTREZGENE
	C6ZII7	ENTREZGENE
	D3YTK6	ENTREZGENE, UniProtKB/TrEMBL
	D3YVQ5	ENTREZGENE, UniProtKB/TrEMBL
	D3YWD6_MOUSE	UniProtKB/TrEMBL
	Q4FJK3	ENTREZGENE, UniProtKB/TrEMBL
	Q8R104	ENTREZGENE
	Q9EPA8	ENTREZGENE
	SIR3_MOUSE	UniProtKB/Swiss-Prot
UniProt Secondary	B9W0A9	UniProtKB/Swiss-Prot
	C6ZII7	UniProtKB/Swiss-Prot
	Q9EPA8	UniProtKB/Swiss-Prot

Nomenclature History

Date	Current Symbol	Current Name	Previous Symbol	Previous Name	Description	Reference	Status
2013-08-06	Sirt3	sirtuin 3		sirtuin 3 (silent mating type information regulation 2, homolog) 3 (S. cerevisiae)	Symbol and/or name change	5135510	APPROVED

Gene Annotator (Functional Annotation) unavailable	Gene Annotator (Annotation Distribution) unavailable	Variant Visualizer (Genomic Variants) unavailble Variant Visualizer (Genomic Variants) unavailable
Gene Annotator (Functional Annotation)	Gene Annotator (Annotation Distribution)	Variant Visualizer (Genomic Variants)

InterViewer (Protein-Protein Interactions) unavailable	Gviewer (Genome Viewer) unavailable	Variant Visualizer (Damaging Variants) unavailble Variant Visualizer (Damaging Variants) unavailable
InterViewer (Protein-Protein Interactions)	GViewer (Genome Viewer)	Variant Visualizer (Damaging Variants)

Gene Annotator (Annotation Comparison) unavailable	OLGA (Gene List Generator) unavailable
Gene Annotator (Annotation Comparison)	OLGA (Gene List Generator)	Excel (Download)

MOET (Multi-Ontology Enrichement) unavailable	GOLF (Gene-Ortholog Location Finder) unavailable
MOET (Multi-Ontology Enrichement)	GOLF (Gene-Ortholog Location Finder)

Send us a Message

Imported Disease Annotations - ClinVar

Imported Disease Annotations - CTD

Imported Disease Annotations - MGI

RGD Manual Annotations

Mammalian Phenotype