|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
chrysoeriol results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] |
CTD |
PMID:20553787 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
|
|
G |
Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] |
CTD |
PMID:20981859 |
|
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:20553787 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:20553787 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:20553787 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] |
CTD |
PMID:20981859 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
|
|
G |
Mtnr1a |
melatonin receptor 1A |
affects binding |
ISO |
chrysoeriol binds to MTNR1A protein |
CTD |
PMID:20399199 |
|
NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
|
|
G |
Mtnr1b |
melatonin receptor 1B |
affects binding |
ISO |
chrysoeriol binds to MTNR1B protein |
CTD |
PMID:20399199 |
|
NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
|
|
G |
Nqo2 |
N-ribosyldihydronicotinamide:quinone dehydrogenase 2 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] |
CTD |
PMID:20399199 |
|
NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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|
G |
Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] |
CTD |
PMID:20981859 |
|
NCBI chr15:53,673,850...53,705,325
Ensembl chr15:53,673,877...53,705,445
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|
|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
acacetin results in decreased expression of CCNB1 protein |
CTD |
PMID:36740148 |
|
NCBI chr 2:31,912,190...31,921,163
Ensembl chr 2:31,912,193...31,921,172
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|
G |
Ccne1 |
cyclin E1 |
decreases expression |
ISO |
acacetin results in decreased expression of CCNE1 protein |
CTD |
PMID:36740148 |
|
NCBI chr 1:90,781,947...90,791,188
Ensembl chr 1:90,781,949...90,791,101
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G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
acacetin results in decreased expression of CDC25C protein |
CTD |
PMID:36740148 |
|
NCBI chr18:26,335,156...26,356,199
Ensembl chr18:26,335,834...26,356,185
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G |
Cdk1 |
cyclin-dependent kinase 1 |
decreases expression |
ISO |
acacetin results in decreased expression of CDK1 protein |
CTD |
PMID:36740148 |
|
NCBI chr20:19,266,226...19,281,417
Ensembl chr20:19,266,248...19,281,408
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|
G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO |
acacetin results in decreased expression of CDK2 protein |
CTD |
PMID:36740148 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
|
|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
acacetin results in increased expression of CDKN1A protein |
CTD |
PMID:36740148 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
|
|
G |
Chek1 |
checkpoint kinase 1 |
increases expression |
ISO |
acacetin results in increased expression of CHK1 protein |
CTD |
PMID:36740148 |
|
NCBI chr 8:36,420,565...36,443,477
Ensembl chr 8:36,420,569...36,441,009
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing increases expression decreases activity |
ISO |
CYP1A1 protein results in increased metabolism of acacetin acacetin results in increased expression of CYP1A1 mRNA acacetin results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO EXP |
acacetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 PMID:32738202 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing increases expression decreases activity multiple interactions |
ISO |
CYP1B1 protein results in increased metabolism of acacetin acacetin results in increased expression of CYP1B1 mRNA acacetin results in decreased activity of CYP1B1 protein acacetin binds to and results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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|
G |
Cyp2b1 |
cytochrome P450, family 2, subfamily b, polypeptide 1 |
decreases activity |
EXP |
acacetin results in decreased activity of CYP2B1 protein |
CTD |
PMID:32738202 |
|
NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052
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|
G |
Cyp2c11 |
cytochrome P450, subfamily 2, polypeptide 11 |
decreases activity |
EXP |
acacetin results in decreased activity of CYP2C11 protein |
CTD |
PMID:32738202 |
|
NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
EXP |
acacetin results in decreased activity of CYP2E1 protein |
CTD |
PMID:32738202 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity multiple interactions increases expression |
EXP ISO |
acacetin results in decreased activity of CYP3A2 protein acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] acacetin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:21053930 PMID:29933105 PMID:32738202 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Fadd |
Fas associated via death domain |
decreases expression |
ISO |
acacetin results in decreased expression of FADD protein |
CTD |
PMID:36740148 |
|
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions increases phosphorylation |
ISO |
Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:36740148 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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|
G |
Mapk3 |
mitogen activated protein kinase 3 |
increases phosphorylation multiple interactions |
ISO |
acacetin results in increased phosphorylation of MAPK3 protein Acetylcysteine inhibits the reaction [acacetin results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:36740148 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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|
G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity increases expression multiple interactions |
ISO |
acacetin results in increased activity of NR1I2 protein acacetin results in increased expression of NR1I2 mRNA acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein] |
CTD |
PMID:25455453 PMID:29933105 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases expression |
ISO |
acacetin results in increased expression of PARP1 protein |
CTD |
PMID:36740148 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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|
G |
Ripk1 |
receptor interacting serine/threonine kinase 1 |
increases expression |
ISO |
acacetin results in increased expression of RIPK1 protein |
CTD |
PMID:36740148 |
|
NCBI chr17:30,839,639...30,871,824
Ensembl chr17:30,839,650...30,871,824
|
|
G |
Ripk3 |
receptor-interacting serine-threonine kinase 3 |
increases expression |
ISO |
acacetin results in increased expression of RIPK3 protein |
CTD |
PMID:36740148 |
|
NCBI chr15:29,283,153...29,292,107
Ensembl chr15:29,283,145...29,292,121
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|
G |
Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
acacetin results in increased expression of UGT1A1 mRNA |
CTD |
PMID:31621310 |
|
NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465
|
|
|
G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
|
|
G |
Acp5 |
acid phosphatase 5, tartrate resistant |
multiple interactions |
ISO |
diosmetin inhibits the reaction [RANK Ligand affects the expression of ACP5 mRNA] |
CTD |
PMID:36563736 |
|
NCBI chr 8:20,663,984...20,670,604
Ensembl chr 8:20,663,985...20,667,929
|
|
G |
Casp1 |
caspase 1 |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP1 protein modified form] |
CTD |
PMID:35191607 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
|
|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]; KEAP1 protein inhibits the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]] |
CTD |
PMID:35191607 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
|
|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity increases response to substance multiple interactions |
ISO |
diosmetin results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased susceptibility to diosmetin [CYP1A1 protein results in increased susceptibility to Luteolin] which results in decreased abundance of diosmetin |
CTD |
PMID:10781868 PMID:21482471 PMID:33727136 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
|
|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity multiple interactions increases response to substance |
ISO |
diosmetin results in decreased activity of CYP1A2 protein [CYP1A2 protein results in increased susceptibility to Luteolin] which results in decreased abundance of diosmetin CYP1A2 protein results in increased susceptibility to diosmetin |
CTD |
PMID:28867436 PMID:33727136 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 PMID:21482471 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
|
|
G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP2C19 protein |
CTD |
PMID:28867436 |
|
NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
|
|
G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP2C8 protein |
CTD |
PMID:28867436 |
|
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP2E1 protein |
CTD |
PMID:28867436 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
|
|
G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] |
CTD |
PMID:18191104 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
|
|
G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] |
CTD |
PMID:18191104 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of HMOX1 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 mRNA]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of HMOX1 protein] |
CTD |
PMID:35191607 |
|
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
|
|
G |
Il18 |
interleukin 18 |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL18 protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL18 protein] |
CTD |
PMID:35191607 |
|
NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of IL1B protein]; diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of IL1B protein] |
CTD |
PMID:35191607 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
EXP |
diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in decreased expression of KEAP1 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein]; KEAP1 protein inhibits the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]]; KEAP1 protein inhibits the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]]; KEAP1 protein inhibits the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein]]; KEAP1 protein inhibits the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]]; NFE2L2 protein promotes the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein]] |
CTD |
PMID:35191607 |
|
NCBI chr 8:19,768,375...19,777,862
Ensembl chr 8:19,768,375...19,777,862
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [RANK Ligand results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:36563736 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
|
|
G |
Mapk14 |
mitogen activated protein kinase 14 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [RANK Ligand results in increased phosphorylation of MAPK14 protein] |
CTD |
PMID:36563736 |
|
NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [RANK Ligand results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:36563736 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
|
|
G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [RANK Ligand results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:36563736 |
|
NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
|
|
G |
Nfatc1 |
nuclear factor of activated T-cells 1 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [RANK Ligand affects the expression of NFATC1 mRNA] |
CTD |
PMID:36563736 |
|
NCBI chr18:74,046,422...74,156,041
Ensembl chr18:74,046,904...74,156,028
|
|
G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
multiple interactions |
EXP |
diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NFE2L2 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]; KEAP1 protein inhibits the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of CASP3 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in decreased expression of KEAP1 protein]]; NFE2L2 protein promotes the reaction [diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of and affects the localization of NFE2L2 protein]] |
CTD |
PMID:35191607 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:16934226 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
|
|
G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NLRP3 protein] |
CTD |
PMID:35191607 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:16934226 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
diosmetin promotes the reaction [[Oxygen deficiency co-treated with Blood Glucose deficiency] results in increased expression of NQO1 protein]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 mRNA]; diosmetin promotes the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of NQO1 protein] |
CTD |
PMID:35191607 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
|
|
G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]; KEAP1 protein inhibits the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]]; NFE2L2 protein promotes the reaction [diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PARP1 protein modified form]] |
CTD |
PMID:35191607 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pkm |
pyruvate kinase M1/2 |
increases activity |
ISO |
diosmetin results in increased activity of PKM protein |
CTD |
PMID:25388478 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pycard |
PYD and CARD domain containing |
multiple interactions |
EXP |
diosmetin inhibits the reaction [[Oxygen deficiency co-treated with Glucose deficiency] results in increased expression of PYCARD protein] |
CTD |
PMID:35191607 |
|
NCBI chr 1:182,601,657...182,603,013
Ensembl chr 1:182,601,174...182,602,955
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G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP |
[diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate |
CTD |
PMID:17108059 |
|
NCBI chr 2:192,123,755...192,144,617
Ensembl chr 2:192,124,289...192,144,611
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G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:28867436 |
|
NCBI chr 1:48,076,657...48,103,679
Ensembl chr 1:48,076,666...48,103,678
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G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] |
CTD |
PMID:28867436 |
|
NCBI chr 4:174,710,004...174,764,810
Ensembl chr 4:174,710,004...175,254,573
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:16934226 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Diosmin binds to and results in increased activity of AHR protein |
CTD |
PMID:14644660 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
EXP |
Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] |
CTD |
PMID:21477647 |
|
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] |
CTD |
PMID:32061149 |
|
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] |
CTD |
PMID:21477647 PMID:32061149 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein] |
CTD |
PMID:21477647 PMID:23665045 PMID:29187079 PMID:32061149 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp7 |
caspase 7 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:255,437,438...255,476,737
Ensembl chr 1:255,437,172...255,476,729
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] |
CTD |
PMID:22056647 PMID:23665045 |
|
NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ceacam1 |
CEA cell adhesion molecule 1 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of CEACAM1 protein] |
CTD |
PMID:35920545 |
|
NCBI chr 1:81,043,595...81,060,050
Ensembl chr 1:81,043,595...81,059,992
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G |
Creb1 |
cAMP responsive element binding protein 1 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased phosphorylation of CREB1 protein] |
CTD |
PMID:35920545 |
|
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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G |
Eno2 |
enolase 2 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of ENO2 protein] |
CTD |
PMID:35920545 |
|
NCBI chr 4:157,572,085...157,580,971
Ensembl chr 4:157,572,088...157,580,980
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G |
Gpx1 |
glutathione peroxidase 1 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of and results in decreased activity of GPX1 protein] |
CTD |
PMID:35920545 |
|
NCBI chr 8:109,026,905...109,028,031
Ensembl chr 8:109,026,905...109,028,024
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr16:58,482,209...58,525,256
Ensembl chr16:58,482,505...58,525,661
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] |
CTD |
PMID:32061149 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mpo |
myeloperoxidase |
multiple interactions |
EXP |
Diosmin inhibits the reaction [Acetic Acid results in increased activity of MPO protein] |
CTD |
PMID:29187079 |
|
NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] |
CTD |
PMID:23665045 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] |
CTD |
PMID:32061149 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] |
CTD |
PMID:23665045 |
|
NCBI chr 3:119,499,039...119,502,911
Ensembl chr 3:119,498,810...119,502,995
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G |
Ptger2 |
prostaglandin E receptor 2 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGER2 protein] |
CTD |
PMID:35920545 |
|
NCBI chr15:18,215,013...18,228,714
Ensembl chr15:18,217,285...18,228,714
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of PTGS2 protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein] |
CTD |
PMID:23665045 PMID:29187079 PMID:32061149 PMID:35920545 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] |
CTD |
PMID:32061149 |
|
NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Acetic Acid results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:21477647 PMID:23665045 PMID:29187079 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] |
CTD |
PMID:23665045 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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G |
Casp1 |
caspase 1 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of CASP1 protein] |
CTD |
PMID:34481870 |
|
NCBI chr 8:2,587,812...2,597,403
Ensembl chr 8:2,587,831...2,597,383
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing decreases activity |
ISO |
CYP1A1 protein results in increased metabolism of genkwanin genkwanin results in decreased activity of CYP1A1 protein |
CTD |
PMID:19666078 PMID:21482471 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of genkwanin |
CTD |
PMID:19666078 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing multiple interactions |
ISO |
CYP1B1 protein results in increased metabolism of genkwanin [CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin |
CTD |
PMID:19666078 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL1B mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of IL6 mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 8:119,074,439...119,078,508
Ensembl chr 8:119,074,437...119,079,415
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G |
Nlrp3 |
NLR family, pyrin domain containing 3 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr10:44,326,770...44,353,814
Ensembl chr10:44,328,566...44,352,811
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]] |
CTD |
PMID:34481870 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Tlr4 |
toll-like receptor 4 |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TLR4 protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of and results in increased activity of CASP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of MYD88 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of NLRP3 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of PTGS2 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL1B protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of IL6 protein]]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] |
CTD |
PMID:34481870 |
|
NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of TNF mRNA]; genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]; TLR4 protein inhibits the reaction [genkwanin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased secretion of TNF protein]] |
CTD |
PMID:34481870 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] |
CTD |
PMID:30055130 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] |
CTD |
PMID:30055130 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] |
CTD |
PMID:30055130 |
|
NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Jak2 |
Janus kinase 2 |
decreases phosphorylation |
ISO |
hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum |
RGD |
PMID:29575334 |
RGD:149735333 |
NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22759588 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22759588 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] |
CTD |
PMID:30055130 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Slc2a1 |
solute carrier family 2 member 1 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [SLC2A1 protein results in increased uptake of 2-(N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino)-2-deoxyglucose] |
CTD |
PMID:36870413 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Slco1c1 |
solute carrier organic anion transporter family, member 1c1 |
decreases activity multiple interactions |
EXP |
hispidulin results in decreased activity of SLCO1B1 protein [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
|
NCBI chr 4:174,466,621...174,513,290
Ensembl chr 4:174,466,631...174,513,289
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G |
Syn1 |
synapsin I |
affects response to substance |
ISO |
SYN1 protein affects the susceptibility to hispidulin |
CTD |
PMID:22759588 |
|
NCBI chr X:1,172,208...1,227,400
Ensembl chr X:1,172,208...1,227,396
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|
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport increases activity multiple interactions decreases expression increases expression |
ISO |
ABCB1 protein results in increased transport of 3-methylquercetin 3-methylquercetin results in increased activity of ABCB1 protein 3-methylquercetin inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]; 3-methylquercetin promotes the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Rhodamine 123]]; 3-methylquercetin promotes the reaction [Quercetin results in increased activity of ABCB1 protein] 3-methylquercetin results in decreased expression of ABCB1 protein 3-methylquercetin results in increased expression of ABCB1 mRNA |
CTD |
PMID:15969930 PMID:26238175 PMID:34217736 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
3-methylquercetin results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
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NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:27151496 |
|
NCBI chr 1:231,746,527...231,759,307
Ensembl chr 1:231,746,548...231,759,554
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G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein] |
CTD |
PMID:17374653 |
|
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] |
CTD |
PMID:19794518 |
|
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO EXP |
3-methylquercetin results in decreased phosphorylation of AKT1 protein 3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:12826665 PMID:19222219 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein |
CTD |
PMID:22992727 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein |
CTD |
PMID:22992727 |
|
NCBI chr 3:141,253,508...141,304,582
Ensembl chr 3:141,253,523...141,303,479
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G |
Casp3 |
caspase 3 |
decreases expression multiple interactions increases activity |
ISO EXP |
3-methylquercetin results in decreased expression of CASP3 protein 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] 3-methylquercetin results in increased activity of CASP3 protein |
CTD |
PMID:12826665 PMID:19222219 PMID:22992727 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of CASP9 protein |
CTD |
PMID:22992727 |
|
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Cat |
catalase |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein |
CTD |
PMID:19222219 PMID:25716194 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA |
CTD |
PMID:20579867 |
|
NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein |
CTD |
PMID:22992727 |
|
NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdh1 |
cadherin 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of CDH1 mRNA; 3-methylquercetin results in increased expression of CDH1 protein |
CTD |
PMID:37537191 |
|
NCBI chr19:34,492,371...34,561,775
Ensembl chr19:34,492,371...34,561,775
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:27151496 |
|
NCBI chr10:79,883,622...79,900,625
Ensembl chr10:79,883,622...79,900,624
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:21329749 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:19794518 |
|
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
3-methylquercetin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] |
CTD |
PMID:18436224 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Esr1 |
estrogen receptor 1 |
affects binding |
ISO |
3-methylquercetin binds to ESR1 protein |
CTD |
PMID:14706564 |
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NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002
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G |
Esr2 |
estrogen receptor 2 |
affects binding |
ISO |
3-methylquercetin binds to ESR2 protein |
CTD |
PMID:14706564 |
|
NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein 3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein |
CTD |
PMID:24211276 PMID:25716194 |
|
NCBI chr 8:78,629,899...78,668,547
Ensembl chr 8:78,630,127...78,668,544
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] |
CTD |
PMID:27151496 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein 3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein |
CTD |
PMID:24211276 PMID:24337631 PMID:25716194 PMID:27151496 |
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NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein] 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA |
CTD |
PMID:20579867 PMID:23774260 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein] 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA |
CTD |
PMID:20579867 PMID:23774260 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Mapk14 |
mitogen activated protein kinase 14 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of MAPK14 mRNA; 3-methylquercetin results in decreased expression of MAPK14 protein |
CTD |
PMID:37537191 |
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NCBI chr20:6,749,646...6,810,590
Ensembl chr20:6,749,670...6,810,589
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19222219 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mir155 |
microRNA 155 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA] |
CTD |
PMID:20579867 |
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NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718
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G |
Mtor |
mechanistic target of rapamycin kinase |
decreases phosphorylation |
ISO |
3-methylquercetin results in decreased phosphorylation of MTOR protein |
CTD |
PMID:37537191 |
|
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] |
CTD |
PMID:17374653 PMID:18436224 |
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NCBI chr12:22,485,382...22,494,647
Ensembl chr12:22,485,451...22,494,646
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G |
Nfe2l2 |
NFE2 like bZIP transcription factor 2 |
affects response to substance multiple interactions affects localization increases activity |
ISO |
NFE2L2 protein affects the susceptibility to 3-methylquercetin 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein] 3-methylquercetin affects the localization of NFE2L2 protein [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide] |
CTD |
PMID:24211276 PMID:27151496 |
|
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:23774260 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA |
CTD |
PMID:16213685 PMID:18178435 PMID:18274639 PMID:20579867 PMID:23774260 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3] |
CTD |
PMID:16891912 |
|
NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA |
CTD |
PMID:24211276 |
|
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
3-methylquercetin binds to and results in increased activity of NR1I2 protein 3-methylquercetin results in increased activity of NR1I2 protein |
CTD |
PMID:26238175 |
|
NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1] |
CTD |
PMID:16891912 |
|
NCBI chr 4:162,926,436...162,949,057
Ensembl chr 4:162,926,439...162,948,523
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
3-methylquercetin results in increased cleavage of PARP1 protein |
CTD |
PMID:22992727 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of PECAM1 protein |
CTD |
PMID:22992727 |
|
NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116
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G |
Pon1 |
paraoxonase 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of PON1 mRNA |
CTD |
PMID:20228421 |
|
NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360
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G |
Pon2 |
paraoxonase 2 |
increases expression |
ISO |
3-methylquercetin results in increased expression of PON2 mRNA |
CTD |
PMID:19865538 |
|
NCBI chr 4:33,389,702...33,425,186
Ensembl chr 4:33,389,714...33,425,248
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases activity |
ISO |
3-methylquercetin results in increased activity of PPARD protein |
CTD |
PMID:22992727 |
|
NCBI chr20:6,298,785...6,363,970
Ensembl chr20:6,298,785...6,363,968
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions increases expression |
ISO |
2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein 3-methylquercetin results in increased expression of PPARG protein |
CTD |
PMID:22992727 |
|
NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkcd |
protein kinase C, delta |
increases phosphorylation |
ISO |
3-methylquercetin results in increased phosphorylation of PRKCD protein |
CTD |
PMID:24211276 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptges |
prostaglandin E synthase |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] |
CTD |
PMID:21341175 |
|
NCBI chr 3:14,177,892...14,189,236
|
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity |
ISO EXP |
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]] 3-methylquercetin results in decreased activity of PTGS2 protein 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein] |
CTD |
PMID:15292928 PMID:21341175 PMID:24337631 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] |
CTD |
PMID:18274639 PMID:20579867 PMID:23774260 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]] 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] |
CTD |
PMID:27151496 |
|
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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G |
Sesn2 |
sestrin 2 |
multiple interactions |
ISO |
[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA |
CTD |
PMID:24211276 |
|
NCBI chr 5:144,702,287...144,721,241
Ensembl chr 5:144,701,530...144,721,260
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G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:27151496 |
|
NCBI chr18:69,849,884...69,918,926
Ensembl chr18:69,850,377...69,912,323
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G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] |
CTD |
PMID:27151496 |
|
NCBI chr 8:64,126,829...64,236,960
Ensembl chr 8:64,110,039...64,236,960
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G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of TFF1 mRNA |
CTD |
PMID:14706564 |
|
NCBI chr20:9,235,736...9,239,597
Ensembl chr20:9,235,736...9,239,597
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] |
CTD |
PMID:27151496 |
|
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein] 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:20579867 PMID:23774260 |
|
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tyr |
tyrosinase |
increases expression |
ISO |
3-methylquercetin results in increased expression of TYR protein |
CTD |
PMID:24853321 |
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NCBI chr 1:141,115,036...141,210,207
Ensembl chr 1:141,115,036...141,210,207
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G |
Tyrp1 |
tyrosinase-related protein 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of TYRP1 protein |
CTD |
PMID:24853321 |
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NCBI chr 5:95,280,982...95,299,516
Ensembl chr 5:95,280,982...95,299,516
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G |
Vim |
vimentin |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of VIM mRNA; 3-methylquercetin results in decreased expression of VIM protein |
CTD |
PMID:37537191 |
|
NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
kaempferide inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]; kaempferide inhibits the reaction [Elacridar inhibits the reaction [ABCB1 protein results in decreased uptake of Daunorubicin]] |
CTD |
PMID:34217736 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Slc2a1 |
solute carrier family 2 member 1 |
decreases expression |
ISO |
kaempferide results in decreased expression of SLC2A1 mRNA |
CTD |
PMID:21865046 |
|
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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G |
Sod1 |
superoxide dismutase 1 |
multiple interactions |
ISO |
kaempferide binds to and affects the folding of SOD1 protein mutant form |
CTD |
PMID:30260512 |
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NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
kaempferide results in increased expression of VEGFA mRNA |
CTD |
PMID:21865046 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression decreases activity multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein; diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA] |
CTD |
PMID:23470866 PMID:30790579 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions decreases activity |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCG2 protein |
CTD |
PMID:32305507 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of BCL2 protein |
CTD |
PMID:19135124 |
|
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP3 protein |
CTD |
PMID:19135124 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein |
CTD |
PMID:19135124 |
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NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP9 protein |
CTD |
PMID:19135124 |
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NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL2 protein] |
CTD |
PMID:32464219 |
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NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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G |
Cdh5 |
cadherin 5 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of CDH5 protein] |
CTD |
PMID:32464219 |
|
NCBI chr19:815,415...854,478
Ensembl chr19:815,411...854,368
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G |
Chek2 |
checkpoint kinase 2 |
increases expression multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form] |
CTD |
PMID:23470866 |
|
NCBI chr12:45,788,823...45,821,382
Ensembl chr12:45,788,827...45,821,286
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CYP1A1 protein |
CTD |
PMID:37515497 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Ece1 |
endothelin converting enzyme 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein] |
CTD |
PMID:26694894 |
|
NCBI chr 5:150,077,679...150,179,375
Ensembl chr 5:150,077,644...150,179,371
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]] |
CTD |
PMID:26694894 |
|
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]] |
CTD |
PMID:29476730 |
|
NCBI chr10:106,072,093...106,090,259
Ensembl chr10:106,072,091...106,090,261
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of FOS protein |
CTD |
PMID:22245252 |
|
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 7:108,416,646...108,419,495
Ensembl chr 7:108,416,642...108,419,494
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G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of CXCL15 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of and affects the localization of HIF1A protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] |
CTD |
PMID:32464219 |
|
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with endotoxin, Escherichia coli] results in increased expression of IL10 protein |
CTD |
PMID:32464219 |
|
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL1B protein] |
CTD |
PMID:22101131 PMID:23236370 PMID:32464219 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein] |
CTD |
PMID:22101131 PMID:23236370 PMID:29476730 PMID:32464219 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Irak4 |
interleukin-1 receptor-associated kinase 4 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IRAK4 protein] |
CTD |
PMID:32464219 |
|
NCBI chr 7:125,682,502...125,708,294
Ensembl chr 7:125,682,488...125,717,837
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK1 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22245252 |
|
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:22245252 |
|
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 protein |
CTD |
PMID:22245252 |
|
NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein] |
CTD |
PMID:22245252 |
|
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:22101131 |
|
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:22101131 PMID:23236370 PMID:26694894 |
|
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases degradation |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein |
CTD |
PMID:19135124 |
|
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 7:116,832,405...116,900,878
Ensembl chr 7:116,832,756...116,895,346
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] |
CTD |
PMID:22245252 |
|
NCBI chr16:5,769,217...5,799,380
Ensembl chr16:5,769,215...5,799,352
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:22101131 |
|
NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:22101131 PMID:26694894 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein] |
CTD |
PMID:26694894 |
|
NCBI chr 8:108,991,926...109,025,746
Ensembl chr 8:108,991,954...109,025,746
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G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
multiple interactions |
EXP |
[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein] |
CTD |
PMID:26694894 |
|
NCBI chr 6:39,679,116...39,774,033
Ensembl chr 6:39,679,082...39,774,031
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562
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G |
Scd2 |
stearoyl-Coenzyme A desaturase 2 |
multiple interactions |
ISO |
[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Ethanol] results in decreased expression of SCD protein |
CTD |
PMID:29476730 |
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NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A6 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:32305507 |
|
NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions decreases activity |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A8 protein |
CTD |
PMID:32159797 PMID:32305507 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
increases uptake |
ISO |
SLCO1B3 protein results in increased uptake of 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one |
CTD |
PMID:32305507 |
|
NCBI chr 4:174,551,463...174,619,988
Ensembl chr 4:174,551,480...174,619,981
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] |
CTD |
PMID:29476730 |
|
NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:23236370 |
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NCBI chr 9:49,419,561...49,459,969
Ensembl chr 9:49,419,340...49,588,540
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G |
Sufu |
SUFU negative regulator of hedgehog signaling |
|
EXP |
oroxylin A increases the expression of Sufu in rat, mouse and human glioma cells |
RGD |
PMID:30790292 |
RGD:150573813 |
NCBI chr 1:245,257,725...245,355,576
Ensembl chr 1:245,257,768...245,355,577
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein |
CTD |
PMID:22245252 |
|
NCBI chr10:103,541,199...103,590,611
Ensembl chr10:103,531,505...103,590,611
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of TJP1 protein] |
CTD |
PMID:32464219 |
|
NCBI chr 1:118,849,838...119,094,492
Ensembl chr 1:118,849,838...119,094,432
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein] |
CTD |
PMID:22101131 PMID:29476730 PMID:32464219 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TP53 protein modified form] |
CTD |
PMID:23470866 |
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NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of VCAM1 protein] |
CTD |
PMID:32464219 |
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NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
pedalitin results in decreased activity of CYP1A2 protein |
CTD |
PMID:29753067 |
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NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp2c6 |
cytochrome P450, family 2, subfamily C, polypeptide 6 |
decreases activity |
ISO |
pedalitin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
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NCBI chr 1:237,938,521...237,976,238
Ensembl chr 1:237,693,094...238,057,596
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
decreases activity |
ISO |
pedalitin results in decreased activity of CYP3A4 protein |
CTD |
PMID:29753067 |
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NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
tamarixetin results in increased expression of ABCB1 mRNA |
CTD |
PMID:26238175 |
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NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
tamarixetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:17090139 |
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NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
tamarixetin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:12826665 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
tamarixetin results in increased activity of CASP3 protein |
CTD |
PMID:12826665 |
|
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
ISO |
tamarixetin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:19034627 |
|
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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G |
Cyp3a2 |
cytochrome P450, family 3, subfamily a, polypeptide 2 |
increases expression |
ISO |
tamarixetin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008
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G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases expression |
ISO |
tamarixetin results in increased expression of CYP3A5 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
tamarixetin binds to and results in increased activity of NR1I2 protein tamarixetin results in increased activity of NR1I2 protein |
CTD |
PMID:26238175 |
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NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity |
ISO |
tamarixetin results in decreased activity of PTGS2 protein |
CTD |
PMID:15292928 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases response to substance decreases activity |
ISO |
[tectochrysin results in decreased activity of ABCB1 protein] which results in decreased export of calcein AM; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Docetaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Paclitaxel]; tectochrysin inhibits the reaction [ABCB1 protein results in decreased susceptibility to Vincristine] ABCB1 protein results in decreased susceptibility to tectochrysin |
CTD |
PMID:37259354 |
|
NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases activity |
ISO |
tectochrysin results in decreased activity of ABCG2 protein |
CTD |
PMID:15930306 |
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NCBI chr 4:87,676,241...87,802,757
Ensembl chr 4:87,745,319...87,802,409
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
increases expression |
ISO |
wogonin analog results in increased expression of ADIPOQ protein; wogonin results in increased expression of ADIPOQ protein |
CTD |
PMID:30445784 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions decreases expression decreases phosphorylation |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of AKT1 protein] wogonin results in decreased expression of AKT1 mRNA wogonin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:37004399 PMID:38134066 |
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NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921
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G |
Alb |
albumin |
multiple interactions |
ISO |
wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein] |
CTD |
PMID:23246481 |
|
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
[wogonin co-treated with Fluorouracil] results in increased expression of BAX protein wogonin results in increased expression of BAX protein |
CTD |
PMID:20570612 PMID:21457722 |
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NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
[wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein wogonin results in decreased expression of BCL2 protein |
CTD |
PMID:20570612 |
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NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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G |
Casp3 |
caspase 3 |
increases activity increases expression multiple interactions |
ISO EXP |
wogonin results in increased activity of CASP3 protein wogonin results in increased expression of CASP3 mRNA wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein] wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein] [wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein |
CTD |
PMID:20570612 PMID:26756871 PMID:31103702 PMID:38134066 |
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NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] |
CTD |
PMID:26756871 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:60,264,075...60,312,542
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein] wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] |
CTD |
PMID:26213241 PMID:31103702 |
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NCBI chr 3:89,842,393...89,874,577
Ensembl chr 3:89,842,399...89,874,478
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein] |
CTD |
PMID:23246481 |
|
NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
wogonin results in decreased expression of CCNA2 protein |
CTD |
PMID:21457722 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:119,426,089...119,433,577
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO EXP |
wogonin results in decreased expression of CCND1 protein |
CTD |
PMID:21457722 PMID:23872260 |
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NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO EXP |
wogonin results in decreased expression of CDK2 protein |
CTD |
PMID:23872260 |
|
NCBI chr 7:1,129,878...1,137,431
Ensembl chr 7:1,129,811...1,137,403
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO EXP |
wogonin results in decreased expression of CDK4 protein |
CTD |
PMID:23872260 |
|
NCBI chr 7:62,886,124...62,889,562
Ensembl chr 7:62,883,105...62,942,403
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G |
Cdk7 |
cyclin-dependent kinase 7 |
decreases activity |
ISO |
wogonin results in decreased activity of CDK7 protein |
CTD |
PMID:37515497 |
|
NCBI chr 2:31,840,558...31,865,422
Ensembl chr 2:31,840,558...31,865,383
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G |
Cdk9 |
cyclin-dependent kinase 9 |
decreases activity |
ISO |
wogonin results in decreased activity of CDK9 protein |
CTD |
PMID:37515497 |
|
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:15,996,468...16,002,410
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein |
CTD |
PMID:32671444 |
|
NCBI chr20:7,149,177...7,159,727
Ensembl chr20:7,149,217...7,159,585
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO EXP |
wogonin results in increased expression of CDKN1B protein |
CTD |
PMID:23872260 |
|
NCBI chr 4:167,760,067...167,765,177
Ensembl chr 4:167,760,181...167,764,982
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein |
CTD |
PMID:32671444 |
|
NCBI chr 5:103,984,949...103,992,143
Ensembl chr 5:103,984,949...104,003,149
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
increases expression |
ISO |
wogonin analog results in increased expression of CEBPA protein; wogonin results in increased expression of CEBPA protein |
CTD |
PMID:30445784 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:87,759,433...87,762,412
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G |
Chrm4 |
cholinergic receptor, muscarinic 4 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in decreased expression of CHRM4 mRNA] |
CTD |
PMID:37004399 |
|
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:77,893,425...77,901,159
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression multiple interactions increases expression |
ISO EXP |
wogonin results in decreased expression of CTNNB1 protein Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein] wogonin results in increased expression of CTNNB1 protein modified form |
CTD |
PMID:23872260 PMID:31103702 |
|
NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases expression |
ISO |
wogonin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]; wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; wogonin results in decreased expression of and results in decreased activity of CYP1A1 protein wogonin results in decreased expression of CYP1A1 mRNA |
CTD |
PMID:18451504 PMID:37515497 |
|
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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G |
Dio1 |
iodothyronine deiodinase 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of DIO1 mRNA] |
CTD |
PMID:37004399 |
|
NCBI chr 5:122,074,285...122,090,983
Ensembl chr 5:122,074,279...122,090,970
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G |
Dpyd |
dihydropyrimidine dehydrogenase |
decreases expression |
ISO |
wogonin results in decreased expression of DPYD mRNA |
CTD |
PMID:20570612 |
|
NCBI chr 2:206,609,043...207,474,982
Ensembl chr 2:206,609,122...207,474,982
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G |
Gabra1 |
gamma-aminobutyric acid type A receptor subunit alpha 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of GABRA1 mRNA] |
CTD |
PMID:37004399 |
|
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:26,595,160...26,650,864
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
ISO EXP |
Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein] |
CTD |
PMID:23872260 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:87,852,890...87,861,589
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G |
Glb1 |
galactosidase, beta 1 |
increases expression |
ISO |
wogonin results in increased expression of GLB1 protein |
CTD |
PMID:32671444 |
|
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:114,085,508...114,158,127
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G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression increases expression |
ISO EXP |
wogonin results in decreased expression of GSK3B protein modified form wogonin results in increased expression of GSK3B protein |
CTD |
PMID:23872260 |
|
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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|
G |
H2ax |
H2A.X variant histone |
increases expression multiple interactions |
ISO |
wogonin results in increased expression of H2AX protein wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein] |
CTD |
PMID:32671444 PMID:37515497 |
|
NCBI chr 8:44,671,907...44,673,262
Ensembl chr 8:44,671,786...44,673,239
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|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein] |
CTD |
PMID:26213241 |
|
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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G |
Htr3a |
5-hydroxytryptamine receptor 3A |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of HTR3A mRNA] |
CTD |
PMID:37004399 |
|
NCBI chr 8:49,242,018...49,254,475
Ensembl chr 8:49,242,020...49,254,389
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G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] |
CTD |
PMID:23362215 |
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NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375
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G |
Ikbkb |
inhibitor of nuclear factor kappa B kinase subunit beta |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of IKBKB protein] |
CTD |
PMID:37004399 |
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NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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G |
Il13 |
interleukin 13 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of IL13 protein] |
CTD |
PMID:37004399 |
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NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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G |
Il17a |
interleukin 17A |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of IL17A protein] |
CTD |
PMID:37004399 |
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NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] |
CTD |
PMID:26213241 PMID:31103702 |
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NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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G |
Il5 |
interleukin 5 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of IL5 protein] |
CTD |
PMID:37004399 |
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NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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G |
Il6 |
interleukin 6 |
increases expression increases secretion |
ISO |
wogonin results in increased expression of IL6 protein wogonin results in increased secretion of IL6 protein wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein |
CTD |
PMID:32671444 |
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NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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G |
Ins1 |
insulin 1 |
increases secretion decreases secretion |
EXP |
wogonin analog results in increased secretion of INS1 protein wogonin results in decreased secretion of INS1 protein |
CTD |
PMID:30445784 |
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NCBI chr 1:251,244,973...251,245,540
Ensembl chr 1:251,244,973...251,245,536
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G |
Ins2 |
insulin 2 |
increases response to substance |
ISO |
wogonin results in increased susceptibility to INS protein |
CTD |
PMID:28854906 |
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NCBI chr 1:197,843,277...197,992,522
Ensembl chr 1:197,843,281...197,864,775
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G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions decreases expression |
ISO |
wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] wogonin results in decreased expression of JUN mRNA |
CTD |
PMID:17570322 PMID:38134066 |
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NCBI chr 5:109,894,175...109,897,268
Ensembl chr 5:109,893,145...109,897,656
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G |
Klf4 |
KLF transcription factor 4 |
multiple interactions |
ISO |
wogonin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells] |
RGD |
PMID:29127880 |
RGD:155230825 |
NCBI chr 5:70,278,843...70,283,751
Ensembl chr 5:70,278,972...70,283,602
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G |
Lep |
leptin |
decreases expression |
ISO |
wogonin analog results in decreased expression of LEP protein; wogonin results in decreased expression of LEP protein |
CTD |
PMID:30445784 |
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NCBI chr 4:57,661,127...57,675,262
Ensembl chr 4:57,661,131...57,675,262
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G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:23362215 |
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NCBI chr 8:64,683,449...64,754,900
Ensembl chr 8:64,683,449...64,755,147
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G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:23362215 |
|
NCBI chr 7:8,590,729...8,610,279
Ensembl chr 7:8,580,905...8,610,243
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] wogonin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:21295103 PMID:23362215 PMID:26892447 |
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NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] wogonin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:21295103 PMID:23362215 PMID:26892447 |
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NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23362215 |
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NCBI chr16:8,638,897...8,721,960
Ensembl chr16:8,638,924...8,721,981
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:23362215 |
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NCBI chr10:34,169,661...34,211,138
Ensembl chr10:34,169,675...34,210,178
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
wogonin results in decreased expression of MKI67 protein |
CTD |
PMID:32671444 |
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NCBI chr 1:190,496,319...190,522,983
Ensembl chr 1:190,496,319...190,522,762
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
wogonin results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:21295103 |
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NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein] wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein |
CTD |
PMID:14700523 PMID:21295103 |
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NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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G |
Nat1 |
N-acetyltransferase 1 |
decreases expression |
ISO |
wogonin results in decreased expression of NAT1 mRNA; wogonin results in decreased expression of NAT1 protein |
CTD |
PMID:15816529 |
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NCBI chr16:22,218,217...22,238,516
Ensembl chr16:22,208,194...22,238,520
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G |
Ncoa2 |
nuclear receptor coactivator 2 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of NCOA2 mRNA] |
CTD |
PMID:37004399 |
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NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:5,835,706...6,067,451
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of NFKBIA protein] |
CTD |
PMID:26213241 |
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NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NOS2 protein] |
CTD |
PMID:14700523 PMID:17570322 PMID:23362215 PMID:26892447 |
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NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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G |
Ogg1 |
8-oxoguanine DNA glycosylase |
multiple interactions |
ISO |
wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA] |
CTD |
PMID:23872129 |
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NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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G |
Pik3ca |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of PIK3CA protein] |
CTD |
PMID:37004399 |
|
NCBI chr 2:115,175,275...115,249,034
Ensembl chr 2:115,174,984...115,249,032
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G |
Pkm |
pyruvate kinase M1/2 |
multiple interactions |
ISO |
wogonin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] |
CTD |
PMID:25388478 |
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NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:60,057,402...60,079,599
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
EXP |
wogonin inhibits the reaction [Cisplatin results in decreased expression of PPARG protein] |
CTD |
PMID:31103702 |
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NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468
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G |
Prkci |
protein kinase C, iota |
multiple interactions |
ISO |
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein] |
CTD |
PMID:21295103 |
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NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:112,321,929...112,382,352
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G |
Prss1 |
serine protease 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of PRSS1 mRNA] |
CTD |
PMID:37004399 |
|
NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:70,364,586...70,367,792
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G |
Ptgs1 |
prostaglandin-endoperoxide synthase 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of PTGS1 mRNA] |
CTD |
PMID:37004399 |
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NCBI chr 3:19,584,015...19,605,589
Ensembl chr 3:19,584,015...19,605,586
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] |
CTD |
PMID:23362215 PMID:26892447 |
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NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188
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G |
Rbp4 |
retinol binding protein 4 |
decreases expression |
ISO |
wogonin analog results in decreased expression of RBP4 protein; wogonin results in decreased expression of RBP4 protein |
CTD |
PMID:30445784 |
|
NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions increases phosphorylation |
ISO EXP |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] wogonin results in increased phosphorylation of RELA protein wogonin inhibits the reaction [Cisplatin results in increased expression of RELA protein] |
CTD |
PMID:23362215 PMID:26213241 PMID:31103702 PMID:32671444 |
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NCBI chr 1:202,925,001...202,935,484
Ensembl chr 1:202,924,945...202,935,484
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G |
Runx1t1 |
RUNX1 partner transcriptional co-repressor 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Ovalbumin results in increased expression of RUNX1T1 mRNA] |
CTD |
PMID:37004399 |
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NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:27,187,551...27,335,592
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G |
Slc22a6 |
solute carrier family 22 member 6 |
multiple interactions decreases activity |
ISO |
[wogonin results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I |
CTD |
PMID:32159797 |
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NCBI chr 1:205,522,579...205,531,179
Ensembl chr 1:205,522,729...205,531,173
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G |
Slc22a8 |
solute carrier family 22 member 8 |
decreases activity multiple interactions |
ISO |
wogonin results in decreased activity of SLC22A8 protein [wogonin results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I |
CTD |
PMID:32159797 |
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NCBI chr 1:205,496,331...205,516,378
Ensembl chr 1:205,498,084...205,517,450
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G |
Slc2a4 |
solute carrier family 2 member 4 |
increases expression |
ISO |
wogonin analog results in increased expression of SLC2A4 protein; wogonin results in increased expression of SLC2A4 protein |
CTD |
PMID:30445784 |
|
NCBI chr10:54,666,015...54,671,581
Ensembl chr10:54,666,015...54,671,565
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G |
Src |
SRC proto-oncogene, non-receptor tyrosine kinase |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] |
CTD |
PMID:23362215 |
|
NCBI chr 3:146,091,969...146,139,492
Ensembl chr 3:146,091,841...146,139,476
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G |
Stat3 |
signal transducer and activator of transcription 3 |
decreases phosphorylation |
ISO |
wogonin results in decreased phosphorylation of STAT3 protein |
CTD |
PMID:32671444 |
|
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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G |
Tnf |
tumor necrosis factor |
multiple interactions decreases expression |
ISO EXP |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; wogonin inhibits the reaction [Ovalbumin results in increased expression of TNF protein] wogonin results in decreased expression of TNF mRNA wogonin analog results in decreased expression of TNF protein; wogonin results in decreased expression of TNF protein wogonin inhibits the reaction [Cisplatin results in increased expression of TNF protein] |
CTD |
PMID:26213241 PMID:30445784 PMID:31103702 PMID:37004399 PMID:38134066 |
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NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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G |
Tp53 |
tumor protein p53 |
increases expression |
ISO |
wogonin results in increased expression of TP53 protein |
CTD |
PMID:21457722 |
|
NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524
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G |
Txnrd2 |
thioredoxin reductase 2 |
decreases expression |
ISO |
wogonin results in decreased expression of TXNRD2 mRNA; wogonin results in decreased expression of TXNRD2 protein |
CTD |
PMID:32671444 |
|
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:82,519,999...82,568,156
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G |
Tyms |
thymidylate synthetase |
multiple interactions increases expression |
ISO |
[wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA wogonin results in increased expression of TYMS mRNA |
CTD |
PMID:20570612 |
|
NCBI chr 9:113,313,454...113,329,551
Ensembl chr 9:113,313,452...113,329,536
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G |
Umps |
uridine monophosphate synthetase |
multiple interactions decreases expression |
ISO |
Fluorouracil inhibits the reaction [wogonin results in decreased expression of UMPS mRNA] |
CTD |
PMID:20570612 |
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NCBI chr11:66,806,107...66,816,520
Ensembl chr11:66,806,045...66,821,903
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
wogonin results in decreased expression of VEGFA mRNA |
CTD |
PMID:38134066 |
|
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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