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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:tamarixetin
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Accession:CHEBI:67492 term browser browse the term
Definition:A monomethoxyflavone that is quercetin methylated at position O-4'. Isolated from Cyperus teneriffae.
Synonyms:exact_synonym: 3,5,7-trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 3,5,7-Trihydroxy-2-(3-hydroxy-4-methoxyphenyl)-4-benzopyrone;   4'-Methoxy-3,3',5,7-tetrahydroxyflavone;   4'-Methoxyquercetin;   Formula=C16H12O7;   InChI=1S/C16H12O7/c1-22-11-3-2-7(4-9(11)18)16-15(21)14(20)13-10(19)5-8(17)6-12(13)23-16/h2-6,17-19,21H,1H3;   InChIKey=FPLMIPQZHHQWHN-UHFFFAOYSA-N;   Quercetin 4'-methyl ether;   SMILES=COc1ccc(cc1O)-c1oc2cc(O)cc(O)c2c(=O)c1O
 alt_id: CHEBI:9393
 xref: CAS:603-61-2;   KEGG:C10188;   KNApSAcK:C00004636
 xref_mesh: MESH:C508967
 xref: PMID:23319447;   Reaxys:324993


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tamarixetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tamarixetin results in increased expression of ABCB1 mRNA CTD PMID:26238175 NCBI chr 4:25,357,467...25,529,941
Ensembl chr 4:25,158,362...25,442,709 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tamarixetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:17090139 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO tamarixetin results in decreased phosphorylation of AKT1 protein CTD PMID:12826665 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Casp3 caspase 3 increases activity ISO tamarixetin results in increased activity of CASP3 protein CTD PMID:12826665 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO tamarixetin results in increased expression of CYP1A2 mRNA CTD PMID:19034627 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 increases expression ISO tamarixetin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 NCBI chr12:9,207,978...9,230,064
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO tamarixetin results in increased expression of CYP3A5 mRNA CTD PMID:26238175 NCBI chr12:16,806,222...16,846,428
Ensembl chr12:16,806,207...16,846,422 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO tamarixetin binds to and results in increased activity of NR1I2 protein
tamarixetin results in increased activity of NR1I2 protein		 CTD PMID:26238175 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO tamarixetin results in decreased activity of PTGS2 protein CTD PMID:15292928 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19932
    role 19904
      chemical role 19529
        antioxidant 16169
          tamarixetin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19932
    subatomic particle 19930
      composite particle 19930
        hadron 19930
          baryon 19930
            nucleon 19930
              atomic nucleus 19930
                atom 19930
                  main group element atom 19876
                    p-block element atom 19876
                      carbon group element atom 19816
                        carbon atom 19812
                          organic molecular entity 19812
                            organic molecule 19764
                              organic cyclic compound 19553
                                organic heterocyclic compound 18905
                                  oxacycle 17908
                                    benzopyran 11984
                                      1-benzopyran 11738
                                        flavonoid 7229
                                          anthoxanthin 4581
                                            flavones 4581
                                              hydroxyflavone 4559
                                                flavonols 4429
                                                  7-hydroxyflavonol 4394
                                                    quercetin 4327
                                                      tamarixetin 9
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