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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,7-dihydroxy-4'-methoxyflavone
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Accession:CHEBI:15335 term browser browse the term
Definition:A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 4'-Methoxy-5,7-dihydroxyflavone;   5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone;   Acacetin;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3;   InChIKey=DANYIYRPLHHOCZ-UHFFFAOYSA-N;   Linarigenin;   SMILES=COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
 alt_id: CHEBI:11915;   CHEBI:20520;   CHEBI:2371
 xref: CAS:480-44-4;   KEGG:C01470;   KNApSAcK:C00003820;   LINCS:LSM-6662;   LIPID_MAPS_instance:LMPK12110468
 xref_mesh: MESH:C023717
 xref: MetaCyc:CPD-1095;   PMID:19693651;   PMID:21993665;   PMID:22360797;   PMID:23325489;   Reaxys:277879;   Wikipedia:Acacetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57284

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5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein		 CTD PMID:10781868, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:10781868, PMID:21053930, PMID:21482471, PMID:31621310 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
increases expression		 ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforafan inhibits the reaction [acacetin results in increased activity of NR1I2 protein]
acacetin results in increased expression of NR1I2 mRNA		 CTD PMID:25455453, PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19810
    role 19758
      biological role 19758
        biochemical role 19304
          metabolite 19285
            apigenin 229
              5,7-dihydroxy-4'-methoxyflavone 5
                acacetin-7-O-beta-D-galactopyranoside 0
                acacetin-8-C-neohesperidoside 0
                isoginkgetin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19810
    subatomic particle 19808
      composite particle 19808
        hadron 19808
          baryon 19808
            nucleon 19808
              atomic nucleus 19808
                atom 19808
                  main group element atom 19696
                    p-block element atom 19696
                      carbon group element atom 19599
                        carbon atom 19588
                          organic molecular entity 19588
                            organic molecule 19514
                              organic cyclic compound 19311
                                organic heterocyclic compound 18425
                                  oxacycle 17200
                                    benzopyran 10149
                                      1-benzopyran 9865
                                        flavonoid 6381
                                          flavones 4171
                                            hydroxyflavone 4159
                                              trihydroxyflavone 339
                                                apigenin 229
                                                  5,7-dihydroxy-4'-methoxyflavone 5
                                                    acacetin-7-O-beta-D-galactopyranoside 0
                                                    acacetin-8-C-neohesperidoside 0
                                                    isoginkgetin 0
paths to the root

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