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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,7-dihydroxy-4'-methoxyflavone
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Accession:CHEBI:15335 term browser browse the term
Definition:A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 4'-Methoxy-5,7-dihydroxyflavone;   5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone;   Acacetin;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3;   InChIKey=DANYIYRPLHHOCZ-UHFFFAOYSA-N;   Linarigenin;   SMILES=COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
 alt_id: CHEBI:11915;   CHEBI:20520;   CHEBI:2371
 xref: CAS:480-44-4;   KEGG:C01470;   KNApSAcK:C00003820;   LINCS:LSM-6662;   LIPID_MAPS_instance:LMPK12110468
 xref_mesh: MESH:C023717
 xref: MetaCyc:CPD-1095;   PMID:19693651;   PMID:21993665;   PMID:22360797;   PMID:23325489;   Reaxys:277879;   Wikipedia:Acacetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57284


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5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
decreases activity
increases expression		 ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in decreased activity of CYP1A1 protein
acacetin results in increased expression of CYP1A1 mRNA		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO
EXP		 acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:32738202 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions
increases expression
decreases activity		 ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin binds to and results in decreased activity of CYP1B1 protein
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP acacetin results in decreased activity of CYP2B1 protein CTD PMID:32738202 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP acacetin results in decreased activity of CYP2C11 protein CTD PMID:32738202 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP acacetin results in decreased activity of CYP2E1 protein CTD PMID:32738202 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
multiple interactions		 EXP
ISO		 acacetin results in decreased activity of CYP3A2 protein
acacetin results in increased expression of CYP3A4 mRNA
acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]		 CTD PMID:21053930 PMID:29933105 PMID:32738202 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
increases expression		 ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein]
acacetin results in increased expression of NR1I2 mRNA		 CTD PMID:25455453 PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:88,801,344...88,808,465
Ensembl chr 9:88,713,184...88,808,465 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19757
    role 19730
      biological role 19728
        biochemical role 19441
          metabolite 19427
            apigenin 259
              5,7-dihydroxy-4'-methoxyflavone 9
                acacetin-7-O-beta-D-galactopyranoside 0
                acacetin-8-C-neohesperidoside 0
                isoginkgetin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19757
    subatomic particle 19755
      composite particle 19755
        hadron 19755
          baryon 19755
            nucleon 19755
              atomic nucleus 19755
                atom 19755
                  main group element atom 19703
                    p-block element atom 19703
                      carbon group element atom 19649
                        carbon atom 19645
                          organic molecular entity 19645
                            organic molecule 19604
                              organic cyclic compound 19407
                                organic heterocyclic compound 18772
                                  oxacycle 17727
                                    benzopyran 11663
                                      1-benzopyran 11429
                                        flavonoid 6782
                                          anthoxanthin 4487
                                            flavones 4487
                                              hydroxyflavone 4474
                                                trihydroxyflavone 385
                                                  apigenin 259
                                                    5,7-dihydroxy-4'-methoxyflavone 9
                                                      acacetin-7-O-beta-D-galactopyranoside 0
                                                      acacetin-8-C-neohesperidoside 0
                                                      isoginkgetin 0
paths to the root