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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:5,7-dihydroxy-4'-methoxyflavone
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Accession:CHEBI:15335 term browser browse the term
Definition:A monomethoxyflavone that is the 4'-methyl ether derivative of apigenin.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 4'-Methoxy-5,7-dihydroxyflavone;   5,7-Dihydroxy-2-(4-methoxyphenyl)-4-benzopyrone;   Acacetin;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-11-4-2-9(3-5-11)14-8-13(19)16-12(18)6-10(17)7-15(16)21-14/h2-8,17-18H,1H3;   InChIKey=DANYIYRPLHHOCZ-UHFFFAOYSA-N;   Linarigenin;   SMILES=COc1ccc(cc1)-c1cc(=O)c2c(O)cc(O)cc2o1
 alt_id: CHEBI:11915;   CHEBI:20520;   CHEBI:2371
 xref: CAS:480-44-4;   KEGG:C01470;   KNApSAcK:C00003820;   LINCS:LSM-6662;   LIPID_MAPS_instance:LMPK12110468
 xref_mesh: MESH:C023717
 xref: MetaCyc:CPD-1095;   PMID:19693651;   PMID:21993665;   PMID:22360797;   PMID:23325489;   Reaxys:277879;   Wikipedia:Acacetin
 cyclic_relationship: is_conjugate_acid_of CHEBI:57284


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5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO
EXP		 acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 PMID:32738202 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917 		JBrowse link
G Cyp2b1 cytochrome P450, family 2, subfamily b, polypeptide 1 decreases activity EXP acacetin results in decreased activity of CYP2B1 protein CTD PMID:32738202 NCBI chr 1:81,518,387...81,544,999
Ensembl chr 1:81,518,408...81,542,052 		JBrowse link
G Cyp2c11 cytochrome P450, subfamily 2, polypeptide 11 decreases activity EXP acacetin results in decreased activity of CYP2C11 protein CTD PMID:32738202 NCBI chr 1:236,762,719...236,799,069
Ensembl chr 1:236,762,842...236,799,066 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity EXP acacetin results in decreased activity of CYP2E1 protein CTD PMID:32738202 NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023 		JBrowse link
G Cyp3a2 cytochrome P450, family 3, subfamily a, polypeptide 2 decreases activity
increases expression
multiple interactions		 EXP
ISO		 acacetin results in decreased activity of CYP3A2 protein
acacetin results in increased expression of CYP3A4 mRNA
acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]		 CTD PMID:21053930 PMID:29933105 PMID:32738202 NCBI chr12:9,207,986...9,230,038
Ensembl chr12:9,015,383...9,285,008 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
multiple interactions
increases expression		 ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforaphane inhibits the reaction [acacetin results in increased activity of NR1I2 protein]
acacetin results in increased expression of NR1I2 mRNA		 CTD PMID:25455453 PMID:29933105 NCBI chr11:62,460,213...62,496,665
Ensembl chr11:62,460,213...62,496,658 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:88,801,344...88,808,465 JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19823
    role 19773
      biological role 19773
        biochemical role 19390
          metabolite 19367
            apigenin 243
              5,7-dihydroxy-4'-methoxyflavone 9
                acacetin-7-O-beta-D-galactopyranoside 0
                acacetin-8-C-neohesperidoside 0
                isoginkgetin 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19823
    subatomic particle 19821
      composite particle 19821
        hadron 19821
          baryon 19821
            nucleon 19821
              atomic nucleus 19821
                atom 19821
                  main group element atom 19720
                    p-block element atom 19720
                      carbon group element atom 19643
                        carbon atom 19633
                          organic molecular entity 19633
                            organic molecule 19572
                              organic cyclic compound 19366
                                organic heterocyclic compound 18604
                                  oxacycle 17622
                                    benzopyran 10410
                                      1-benzopyran 10137
                                        flavonoid 6518
                                          flavones 4206
                                            hydroxyflavone 4194
                                              trihydroxyflavone 353
                                                apigenin 243
                                                  5,7-dihydroxy-4'-methoxyflavone 9
                                                    acacetin-7-O-beta-D-galactopyranoside 0
                                                    acacetin-8-C-neohesperidoside 0
                                                    isoginkgetin 0
paths to the root