CHEBI ONTOLOGY - ANNOTATIONS |
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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
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Term: | methoxyflavone |
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Accession: | CHEBI:25241
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browse the term
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Definition: | Any member of the class of flavones with at least one methoxy substituent. |
Synonyms: | related_synonym: | methoxyflavones |
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Ccnb1 |
cyclin B1 |
affects phosphorylation increases expression |
ISO |
5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CCNB1 protein 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CCNB1 protein |
CTD |
PMID:21229608 |
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NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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Cdc25c |
cell division cycle 25C |
affects phosphorylation |
ISO |
5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDC25C protein |
CTD |
PMID:21229608 |
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NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
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Cdk1 |
cyclin-dependent kinase 1 |
affects phosphorylation |
ISO |
5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDK1 protein |
CTD |
PMID:21229608 |
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NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549
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Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CDKN1A protein |
CTD |
PMID:21229608 |
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NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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Foxm1 |
forkhead box M1 |
affects phosphorylation |
ISO |
5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of FOXM1 protein |
CTD |
PMID:21229608 |
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NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305
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Smpd1 |
sphingomyelin phosphodiesterase 1 |
increases activity |
ISO |
5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased activity of SMPD1 protein |
CTD |
PMID:21229608 |
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NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] |
CTD |
PMID:16552572 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
3',5'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:12644593 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
chrysoeriol results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
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NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] |
CTD |
PMID:20553787 |
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NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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Bglap |
bone gamma-carboxyglutamate protein |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] |
CTD |
PMID:20981859 |
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NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:20553787 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] |
CTD |
PMID:20553787 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] |
CTD |
PMID:20553787 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Il6 |
interleukin 6 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] |
CTD |
PMID:20981859 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Mtnr1a |
melatonin receptor 1A |
affects binding |
ISO |
chrysoeriol binds to MTNR1A protein |
CTD |
PMID:20399199 |
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NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
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Mtnr1b |
melatonin receptor 1B |
affects binding |
ISO |
chrysoeriol binds to MTNR1B protein |
CTD |
PMID:20399199 |
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NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
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Nqo2 |
N-ribosyldihydronicotinamide:quinone reductase 2 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] |
CTD |
PMID:20399199 |
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NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
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Tnfsf11 |
TNF superfamily member 11 |
multiple interactions |
ISO |
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] |
CTD |
PMID:20981859 |
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NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
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Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] |
CTD |
PMID:24161485 |
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NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] |
CTD |
PMID:24161485 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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Il6 |
interleukin 6 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] |
CTD |
PMID:24161485 |
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NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] |
CTD |
PMID:24161485 |
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NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
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Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:24161485 |
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NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide |
CTD |
PMID:24161485 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone |
CTD |
PMID:24161485 |
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NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] |
CTD |
PMID:24161485 |
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NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:24161485 |
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NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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Stat3 |
signal transducer and activator of transcription 3 |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] |
CTD |
PMID:24161485 |
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NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233
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Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] |
CTD |
PMID:24161485 |
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NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing increases expression decreases activity |
ISO |
CYP1A1 protein results in increased metabolism of acacetin acacetin results in increased expression of CYP1A1 mRNA acacetin results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
acacetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:21053930 |
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NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing increases expression decreases activity multiple interactions |
ISO |
CYP1B1 protein results in increased metabolism of acacetin acacetin results in increased expression of CYP1B1 mRNA acacetin results in decreased activity of CYP1B1 protein acacetin binds to and results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases expression multiple interactions |
ISO |
acacetin results in increased expression of CYP3A4 mRNA acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam] |
CTD |
PMID:21053930 PMID:29933105 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
increases activity increases expression multiple interactions |
ISO |
acacetin results in increased activity of NR1I2 protein acacetin results in increased expression of NR1I2 mRNA acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforafan inhibits the reaction [acacetin results in increased activity of NR1I2 protein] |
CTD |
PMID:25455453 PMID:29933105 |
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NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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Ugt1a1 |
UDP glucuronosyltransferase family 1 member A1 |
increases expression |
ISO |
acacetin results in increased expression of UGT1A1 mRNA |
CTD |
PMID:31621310 |
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NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822
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Abcc5 |
ATP binding cassette subfamily C member 5 |
increases expression |
ISO |
casticin results in increased expression of ABCC5 mRNA |
CTD |
PMID:28444820 |
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NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211
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Adam10 |
ADAM metallopeptidase domain 10 |
increases expression |
ISO |
casticin results in increased expression of ADAM10 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483
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Aftph |
aftiphilin |
decreases expression |
ISO |
casticin results in decreased expression of AFTPH mRNA |
CTD |
PMID:28444820 |
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NCBI chr14:104,921,633...104,975,763
Ensembl chr14:104,922,282...104,960,141
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Agap1 |
ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 |
decreases expression |
ISO |
casticin results in decreased expression of AGAP1 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 9:96,718,901...97,034,400
Ensembl chr 9:96,621,586...97,030,163
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Aifm1 |
apoptosis inducing factor, mitochondria associated 1 |
increases expression |
ISO |
casticin results in increased expression of AIFM1 protein |
CTD |
PMID:29098808 |
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NCBI chr X:135,304,063...135,343,062
Ensembl chr X:135,304,066...135,343,087
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Akirin2 |
akirin 2 |
decreases expression |
ISO |
casticin results in decreased expression of AKIRIN2 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 5:50,001,945...50,016,544
Ensembl chr 5:50,002,184...50,016,539
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Akt1 |
AKT serine/threonine kinase 1 |
decreases expression |
ISO |
casticin results in decreased expression of AKT1 protein |
CTD |
PMID:28444820 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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Akt3 |
AKT serine/threonine kinase 3 |
decreases expression |
ISO |
casticin results in decreased expression of AKT3 mRNA |
CTD |
PMID:27862857 |
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NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913
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Aldh1a1 |
aldehyde dehydrogenase 1 family, member A1 |
increases expression |
ISO |
casticin results in increased expression of ALDH1A1 mRNA |
CTD |
PMID:27862857 |
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NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330
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Alx1 |
ALX homeobox 1 |
decreases expression |
ISO |
casticin results in decreased expression of ALX1 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 7:44,751,865...44,771,458
Ensembl chr 7:44,751,873...44,771,458
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Apaf1 |
apoptotic peptidase activating factor 1 |
increases expression |
ISO |
casticin results in increased expression of APAF1 protein |
CTD |
PMID:27862857 |
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NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192
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Arl6ip4 |
ADP-ribosylation factor like GTPase 6 interacting protein 4 |
decreases expression |
ISO |
casticin results in decreased expression of ARL6IP4 mRNA |
CTD |
PMID:28444820 |
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NCBI chr12:37,904,376...37,906,521
Ensembl chr12:37,904,379...37,906,521
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Armc9 |
armadillo repeat containing 9 |
decreases expression |
ISO |
casticin results in decreased expression of ARMC9 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 9:93,172,718...93,299,119
Ensembl chr 9:93,172,673...93,296,750
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Arntl |
aryl hydrocarbon receptor nuclear translocator-like |
decreases expression |
ISO |
casticin results in decreased expression of ARNTL mRNA |
CTD |
PMID:28444820 |
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NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465
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Arpc5l |
actin related protein 2/3 complex, subunit 5-like |
decreases expression |
ISO |
casticin results in decreased expression of ARPC5L mRNA |
CTD |
PMID:28444820 |
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NCBI chr 3:23,301,455...23,309,077
Ensembl chr 3:23,301,455...23,309,072
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Asns |
asparagine synthetase (glutamine-hydrolyzing) |
decreases expression |
ISO |
casticin results in decreased expression of ASNS mRNA |
CTD |
PMID:28444820 |
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NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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Atf5 |
activating transcription factor 5 |
decreases expression |
ISO |
casticin results in decreased expression of ATF5 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522
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Atf6 |
activating transcription factor 6 |
increases expression |
ISO |
casticin results in increased expression of ATF6 protein |
CTD |
PMID:27862857 |
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NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443
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Atm |
ATM serine/threonine kinase |
decreases expression |
ISO |
casticin results in decreased expression of ATM protein |
CTD |
PMID:29098808 |
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NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045
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Atox1 |
antioxidant 1 copper chaperone |
increases expression |
ISO |
casticin results in increased expression of ATOX1 mRNA |
CTD |
PMID:28444820 |
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NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941
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Atp6v1g1 |
ATPase H+ transporting V1 subunit G1 |
decreases expression |
ISO |
casticin results in decreased expression of ATP6V1G1 mRNA |
CTD |
PMID:28444820 |
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NCBI chr 5:79,367,663...79,373,843
Ensembl chr 5:79,367,663...79,373,843
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Atp8a1 |
ATPase phospholipid transporting 8A1 |
increases expression |
ISO |
casticin results in increased expression of ATP8A1 mRNA |
CTD |
PMID:28444820 |
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NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311
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Atr |
ATR serine/threonine kinase |
decreases expression |
ISO |
casticin results in decreased expression of ATR protein |
CTD |
PMID:29098808 |
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NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947
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Atxn7l3b |
ataxin 7-like 3B |
decreases expression |
ISO |
casticin results in decreased expression of ATXN7L3B mRNA |
CTD |
PMID:28444820 |
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NCBI chr 7:55,600,879...55,604,403
Ensembl chr 7:55,600,889...55,604,403
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Avpr1a |
arginine vasopressin receptor 1A |
decreases expression |
ISO |
casticin results in decreased expression of AVPR1A mRNA |
CTD |
PMID:28444820 |
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NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308
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Axin2 |
axin 2 |
increases expression |
ISO |
casticin results in increased expression of AXIN2 mRNA |
CTD |
PMID:27862857 |
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NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642
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Bak1 |
BCL2-antagonist/killer 1 |
increases expression |
ISO |
casticin results in increased expression of BAK1 protein |
CTD |
PMID:27862857 |
|
NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260
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G |
Bambi |
BMP and activin membrane-bound inhibitor |
increases expression |
ISO |
casticin results in increased expression of BAMBI mRNA |
CTD |
PMID:27862857 |
|
NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992
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G |
Basp1 |
brain abundant, membrane attached signal protein 1 |
decreases expression |
ISO |
casticin results in decreased expression of BASP1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628
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G |
Bax |
BCL2 associated X, apoptosis regulator |
increases expression |
ISO |
casticin results in increased expression of BAX protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl11a |
BAF chromatin remodeling complex subunit BCL11A |
decreases expression |
ISO |
casticin results in decreased expression of BCL11A mRNA |
CTD |
PMID:28444820 |
|
NCBI chr14:108,826,717...108,921,197
Ensembl chr14:108,826,831...108,921,669
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
casticin results in decreased expression of BCL2 protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression increases expression |
ISO |
casticin results in decreased expression of BCL2L1 protein casticin results in increased expression of BCL2L1 mRNA |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Bid |
BH3 interacting domain death agonist |
increases expression decreases expression |
ISO |
casticin results in increased expression of BID protein casticin results in decreased expression of BID protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203
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G |
Bmi1 |
BMI1 proto-oncogene, polycomb ring finger |
multiple interactions decreases expression |
ISO |
casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA] |
CTD |
PMID:32268151 |
|
NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208
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G |
Bmp4 |
bone morphogenetic protein 4 |
increases expression |
ISO |
casticin results in increased expression of BMP4 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740
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G |
Bnip2 |
BCL2 interacting protein 2 |
decreases expression |
ISO |
casticin results in decreased expression of BNIP2 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 8:76,400,333...76,426,307
Ensembl chr 8:76,400,341...76,426,503
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G |
Brca1 |
BRCA1, DNA repair associated |
increases expression |
ISO |
casticin results in increased expression of BRCA1 protein |
CTD |
PMID:29098808 |
|
NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681
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|
G |
Btf3 |
basic transcription factor 3 |
decreases expression |
ISO |
casticin results in decreased expression of BTF3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:28,417,316...28,424,436
Ensembl chr 2:28,417,579...28,423,762
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|
G |
Btg1 |
BTG anti-proliferation factor 1 |
decreases expression |
ISO |
casticin results in decreased expression of BTG1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088
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|
G |
Cadm1 |
cell adhesion molecule 1 |
increases expression |
ISO |
casticin results in increased expression of CADM1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722
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|
G |
Calcoco1 |
calcium binding and coiled coil domain 1 |
decreases expression |
ISO |
casticin results in decreased expression of CALCOCO1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:144,307,562...144,322,253
Ensembl chr 7:144,307,509...144,322,240
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|
G |
Calm1 |
calmodulin 1 |
decreases expression |
ISO |
casticin results in decreased expression of CALM1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292
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|
G |
Camk4 |
calcium/calmodulin-dependent protein kinase IV |
decreases expression |
ISO |
casticin results in decreased expression of CAMK4 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957
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G |
Capn1 |
calpain 1 |
multiple interactions |
ISO |
casticin results in increased expression of and results in increased cleavage of CAPN1 protein |
CTD |
PMID:27862857 |
|
NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322
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|
G |
Capn2 |
calpain 2 |
increases expression |
ISO |
casticin results in increased expression of CAPN2 protein |
CTD |
PMID:27862857 |
|
NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811
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|
G |
Casp2 |
caspase 2 |
increases expression |
ISO |
casticin results in increased expression of CASP2 protein |
CTD |
PMID:27862857 |
|
NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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|
G |
Casp3 |
caspase 3 |
multiple interactions increases activity |
ISO |
casticin results in increased cleavage of and results in increased activity of CASP3 protein casticin results in increased activity of CASP3 protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Casp4 |
caspase 4 |
increases expression |
ISO |
casticin results in increased expression of CASP4 protein |
CTD |
PMID:27862857 |
|
NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652
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|
G |
Casp6 |
caspase 6 |
increases expression |
ISO |
casticin results in increased expression of CASP6 protein |
CTD |
PMID:27862857 |
|
NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967 Ensembl chr 2:235,341,365...235,353,967
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|
G |
Casp7 |
caspase 7 |
increases expression |
ISO |
casticin results in increased expression of CASP7 protein |
CTD |
PMID:27862857 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
casticin results in increased cleavage of and results in increased activity of CASP8 protein; casticin results in increased expression of and results in increased activity of CASP8 protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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|
G |
Casp9 |
caspase 9 |
multiple interactions increases activity |
ISO |
casticin results in increased cleavage of and results in increased activity of CASP9 protein casticin results in increased activity of CASP9 protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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|
G |
Ccdc122 |
coiled-coil domain containing 122 |
increases expression |
ISO |
casticin results in increased expression of CCDC122 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr15:59,159,822...59,280,538
Ensembl chr15:59,216,705...59,279,967
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|
G |
Ccdc174 |
coiled-coil domain containing 174 |
decreases expression |
ISO |
casticin results in decreased expression of CCDC174 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:123,760,708...123,787,529
Ensembl chr 4:123,760,743...123,787,528
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|
G |
Ccdc90b |
coiled-coil domain containing 90B |
decreases expression |
ISO |
casticin results in decreased expression of CCDC90B mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:157,403,595...157,417,153
Ensembl chr 1:157,403,595...157,417,147
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|
G |
Ccn1 |
cellular communication network factor 1 |
increases expression |
ISO |
casticin results in increased expression of CCN1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312
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|
G |
Ccnb1 |
cyclin B1 |
decreases expression |
ISO |
casticin results in decreased expression of CCNB1 protein |
CTD |
PMID:29098808 |
|
NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221
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|
G |
Cct4 |
chaperonin containing TCP1 subunit 4 |
decreases expression |
ISO |
casticin results in decreased expression of CCT4 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr14:107,767,392...107,780,270
Ensembl chr14:107,767,392...107,780,270
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|
G |
Cd24 |
CD24 molecule |
increases expression |
ISO |
casticin results in increased expression of CD24 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846
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|
G |
Cd44 |
CD44 molecule (Indian blood group) |
decreases expression multiple interactions |
ISO |
casticin results in decreased expression of CD44 mRNA; casticin results in decreased expression of CD44 protein casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein] |
CTD |
PMID:32268151 |
|
NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658
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|
G |
Cd83 |
CD83 molecule |
decreases expression |
ISO |
casticin results in decreased expression of CD83 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790
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|
G |
Cdc25c |
cell division cycle 25C |
decreases expression |
ISO |
casticin results in decreased expression of CDC25C protein |
CTD |
PMID:29098808 |
|
NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224
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|
G |
Cdc42 |
cell division cycle 42 |
decreases expression |
ISO |
casticin results in decreased expression of CDC42 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300
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|
G |
Cdh17 |
cadherin 17 |
increases expression |
ISO |
casticin results in increased expression of CDH17 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718
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|
G |
Cdk2 |
cyclin dependent kinase 2 |
increases expression |
ISO |
casticin results in increased expression of CDK2 protein |
CTD |
PMID:29098808 |
|
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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|
G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
decreases expression |
ISO |
casticin results in decreased expression of CDKN1A mRNA; casticin results in decreased expression of CDKN1A protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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|
G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO |
casticin results in increased expression of CDKN1B mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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|
G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
casticin results in increased expression of CDKN2A protein |
CTD |
PMID:29098808 |
|
NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
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|
G |
Chek2 |
checkpoint kinase 2 |
increases expression |
ISO |
casticin results in increased expression of CHEK2 protein |
CTD |
PMID:29098808 |
|
NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
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|
G |
Chic2 |
cysteine-rich hydrophobic domain 2 |
decreases expression |
ISO |
casticin results in decreased expression of CHIC2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr14:35,683,657...35,718,005
Ensembl chr14:35,683,442...35,717,922
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|
G |
Cldn1 |
claudin 1 |
decreases expression |
ISO |
casticin results in decreased expression of CLDN1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416
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|
G |
Cnbp |
CCHC-type zinc finger, nucleic acid binding protein |
decreases expression |
ISO |
casticin results in decreased expression of CNBP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765
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|
G |
Col1a1 |
collagen type I alpha 1 chain |
decreases expression |
ISO |
casticin results in decreased expression of COL1A1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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|
G |
Cpe |
carboxypeptidase E |
increases expression |
ISO |
casticin results in increased expression of CPE mRNA |
CTD |
PMID:28444820 |
|
NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813
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|
G |
Creb1 |
cAMP responsive element binding protein 1 |
increases expression |
ISO |
casticin results in increased expression of CREB1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435
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|
G |
Crhbp |
corticotropin releasing hormone binding protein |
decreases expression |
ISO |
casticin results in decreased expression of CRHBP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334
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|
G |
Crls1 |
cardiolipin synthase 1 |
decreases expression |
ISO |
casticin results in decreased expression of CRLS1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:125,503,638...125,522,460
Ensembl chr 3:125,503,638...125,522,441
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|
G |
Cryab |
crystallin, alpha B |
increases expression |
ISO |
casticin results in increased expression of CRYAB mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545
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|
G |
Csnk1a1 |
casein kinase 1, alpha 1 |
decreases expression |
ISO |
casticin results in decreased expression of CSNK1A1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345
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|
G |
Cyb5r1 |
cytochrome b5 reductase 1 |
decreases expression |
ISO |
casticin results in decreased expression of CYB5R1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr13:51,229,697...51,236,447
Ensembl chr13:51,229,890...51,236,463
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|
G |
Cycs |
cytochrome c, somatic |
increases expression |
ISO |
casticin results in increased expression of CYCS protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326
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|
G |
Ddit3 |
DNA-damage inducible transcript 3 |
decreases expression |
ISO |
casticin results in decreased expression of DDIT3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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|
G |
Ddx27 |
DEAD-box helicase 27 |
decreases expression |
ISO |
casticin results in decreased expression of DDX27 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:163,767,236...163,786,408
Ensembl chr 3:163,767,173...163,786,445
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|
G |
Dip2c |
disco-interacting protein 2 homolog C |
decreases expression |
ISO |
casticin results in decreased expression of DIP2C mRNA |
CTD |
PMID:28444820 |
|
NCBI chr17:63,426,688...63,810,183
Ensembl chr17:63,635,086...63,808,464
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|
G |
Dkk3 |
dickkopf WNT signaling pathway inhibitor 3 |
decreases expression |
ISO |
casticin results in decreased expression of DKK3 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045
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|
G |
Dnmt1 |
DNA methyltransferase 1 |
multiple interactions decreases activity decreases expression |
ISO |
casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin results in decreased expression of and results in decreased activity of DNMT1 protein; DNMT1 protein inhibits the reaction [casticin results in decreased activity of DNMT1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein] |
CTD |
PMID:32268151 |
|
NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495
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|
G |
Dusp6 |
dual specificity phosphatase 6 |
decreases expression |
ISO |
casticin results in decreased expression of DUSP6 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392
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|
G |
Dyrk1a |
dual specificity tyrosine phosphorylation regulated kinase 1A |
decreases expression |
ISO |
casticin results in decreased expression of DYRK1A mRNA |
CTD |
PMID:28444820 |
|
NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536
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|
G |
Egfr |
epidermal growth factor receptor |
decreases expression |
ISO |
casticin results in decreased expression of EGFR protein |
CTD |
PMID:28444820 |
|
NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796
|
|
G |
Eif2s2 |
eukaryotic translation initiation factor 2 subunit beta |
decreases expression |
ISO |
casticin results in decreased expression of EIF2S2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:150,391,455...150,412,179
Ensembl chr 3:150,391,460...150,412,179
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|
G |
Eif5 |
eukaryotic translation initiation factor 5 |
decreases expression |
ISO |
casticin results in decreased expression of EIF5 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406
|
|
G |
Enc1 |
ectodermal-neural cortex 1 |
increases expression |
ISO |
casticin results in increased expression of ENC1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029
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|
G |
Endog |
endonuclease G |
decreases expression |
ISO |
casticin results in decreased expression of ENDOG protein |
CTD |
PMID:29098808 |
|
NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592
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|
G |
Ep300 |
E1A binding protein p300 |
decreases expression |
ISO |
casticin results in decreased expression of EP300 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296
|
|
G |
Epb41l4b |
erythrocyte membrane protein band 4.1 like 4B |
decreases expression |
ISO |
casticin results in decreased expression of EPB41L4B mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:74,030,950...74,192,275
Ensembl chr 5:74,030,882...74,191,167
|
|
G |
Epcam |
epithelial cell adhesion molecule |
multiple interactions decreases expression |
ISO |
casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA] |
CTD |
PMID:32268151 |
|
NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216
|
|
G |
Erbb3 |
erb-b2 receptor tyrosine kinase 3 |
increases expression |
ISO |
casticin results in increased expression of ERBB3 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350
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G |
Esf1 |
ESF1 nucleolar pre-rRNA processing protein homolog |
decreases expression |
ISO |
casticin results in decreased expression of ESF1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:133,178,591...133,232,358
Ensembl chr 3:133,178,561...133,232,322
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|
G |
Exosc3 |
exosome component 3 |
decreases expression |
ISO |
casticin results in decreased expression of EXOSC3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705
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G |
Ext1 |
exostosin glycosyltransferase 1 |
increases expression |
ISO |
casticin results in increased expression of EXT1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068
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G |
Fadd |
Fas associated via death domain |
increases expression |
ISO |
casticin results in increased expression of FADD protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628
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G |
Fam227a |
family with sequence similarity 227, member A |
increases expression |
ISO |
casticin results in increased expression of FAM227A mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:120,846,166...120,891,738
Ensembl chr 7:120,846,330...120,882,392
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G |
Fas |
Fas cell surface death receptor |
increases expression |
ISO |
casticin results in increased expression of FAS protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790
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G |
Faslg |
Fas ligand |
increases expression decreases expression |
ISO |
casticin results in increased expression of FASLG protein casticin results in decreased expression of FASLG protein |
CTD |
PMID:27862857 PMID:29098808 |
|
NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705
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G |
Fbxo11 |
F-box protein 11 |
decreases expression |
ISO |
casticin results in decreased expression of FBXO11 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:11,662,356...11,737,427
Ensembl chr 6:11,662,356...11,686,682
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G |
Fbxo44 |
F-box protein 44 |
decreases expression |
ISO |
casticin results in decreased expression of FBXO44 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:164,962,921...164,972,273
Ensembl chr 5:164,963,433...164,971,903
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G |
Fez1 |
fasciculation and elongation protein zeta 1 |
decreases expression |
ISO |
casticin results in decreased expression of FEZ1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270
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|
G |
Foxo3 |
forkhead box O3 |
decreases expression |
ISO |
casticin results in decreased expression of FOXO3 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144
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G |
Foxp2 |
forkhead box P2 |
decreases expression |
ISO |
casticin results in decreased expression of FOXP2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023
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|
G |
Gadd45a |
growth arrest and DNA-damage-inducible, alpha |
decreases expression |
ISO |
casticin results in decreased expression of GADD45A mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842
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|
G |
Glud1 |
glutamate dehydrogenase 1 |
decreases expression |
ISO |
casticin results in decreased expression of GLUD1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557
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|
G |
Gphn |
gephyrin |
decreases expression |
ISO |
casticin results in decreased expression of GPHN mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164
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|
G |
Gpr85 |
G protein-coupled receptor 85 |
decreases expression |
ISO |
casticin results in decreased expression of GPR85 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349
|
|
G |
Grb2 |
growth factor receptor bound protein 2 |
decreases expression |
ISO |
casticin results in decreased expression of GRB2 protein |
CTD |
PMID:28444820 |
|
NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071
|
|
G |
Grid2 |
glutamate ionotropic receptor delta type subunit 2 |
decreases expression |
ISO |
casticin results in decreased expression of GRID2 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 4:94,068,112...95,476,864
Ensembl chr 4:94,696,965...95,442,778
|
|
G |
Hcn2 |
hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 |
decreases expression |
ISO |
casticin results in decreased expression of HCN2 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215
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G |
Hoxb8 |
homeo box B8 |
decreases expression |
ISO |
casticin results in decreased expression of HOXB8 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:84,131,484...84,133,874
Ensembl chr10:84,131,495...84,133,246
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G |
Hoxb9 |
homeo box B9 |
decreases expression |
ISO |
casticin results in decreased expression of HOXB9 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390
|
|
G |
Hspa4 |
heat shock protein family A (Hsp70) member 4 |
decreases expression |
ISO |
casticin results in decreased expression of HSPA4 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397
|
|
G |
Hspa5 |
heat shock protein family A (Hsp70) member 5 |
increases expression |
ISO |
casticin results in increased expression of HSPA5 protein |
CTD |
PMID:27862857 |
|
NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762
|
|
G |
Hspa8 |
heat shock protein family A (Hsp70) member 8 |
increases expression |
ISO |
casticin results in increased expression of HSPA8 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179
|
|
G |
Hspa9 |
heat shock protein family A (Hsp70) member 9 |
decreases expression |
ISO |
casticin results in decreased expression of HSPA9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235
|
|
G |
Il12a |
interleukin 12A |
decreases expression |
ISO |
casticin results in decreased expression of IL12A mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318
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|
G |
Il6 |
interleukin 6 |
decreases expression |
ISO |
casticin results in decreased expression of IL6 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Ints6 |
integrator complex subunit 6 |
decreases expression |
ISO |
casticin results in decreased expression of INTS6 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr15:45,844,050...45,929,996
Ensembl chr15:45,858,608...45,947,030
|
|
G |
Irak4 |
interleukin-1 receptor-associated kinase 4 |
increases expression |
ISO |
casticin results in increased expression of IRAK4 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
|
|
G |
Irf2bp2 |
interferon regulatory factor 2 binding protein 2 |
decreases expression |
ISO |
casticin results in decreased expression of IRF2BP2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr19:59,497,021...59,502,298
Ensembl chr19:59,499,876...59,502,161
|
|
G |
Kcnh2 |
potassium voltage-gated channel subfamily H member 2 |
decreases expression |
ISO |
casticin results in decreased expression of KCNH2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253
|
|
G |
Kctd9 |
potassium channel tetramerization domain containing 9 |
decreases expression |
ISO |
casticin results in decreased expression of KCTD9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr15:44,411,591...44,439,645
Ensembl chr15:44,411,865...44,439,236
|
|
G |
Kirrel3 |
kirre like nephrin family adhesion molecule 3 |
decreases expression |
ISO |
casticin results in decreased expression of KIRREL3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:35,692,525...36,254,755
Ensembl chr 8:36,125,999...36,254,753
|
|
G |
Klf9 |
Kruppel-like factor 9 |
decreases expression |
ISO |
casticin results in decreased expression of KLF9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198
|
|
G |
Krt16 |
keratin 16 |
increases expression |
ISO |
casticin results in increased expression of KRT16 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:88,149,210...88,152,167
Ensembl chr10:88,149,345...88,152,064
|
|
G |
Ldhb |
lactate dehydrogenase B |
decreases expression |
ISO |
casticin results in decreased expression of LDHB mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012
|
|
G |
Lef1 |
lymphoid enhancer binding factor 1 |
decreases expression |
ISO |
casticin results in decreased expression of LEF1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056
|
|
G |
Lhfpl6 |
LHFPL tetraspan subfamily member 6 |
increases expression |
ISO |
casticin results in increased expression of LHFP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:142,262,236...142,461,980
Ensembl chr 2:142,262,236...142,461,980
|
|
G |
Limch1 |
LIM and calponin homology domains 1 |
increases expression |
ISO |
casticin results in increased expression of LIMCH1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr14:42,760,363...43,072,976
Ensembl chr14:42,762,587...43,072,843
|
|
G |
LOC102553180 |
protocadherin alpha-1-like |
increases expression |
ISO |
casticin results in increased expression of PCDHA1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:29,824,891...29,839,850
|
|
G |
Lpl |
lipoprotein lipase |
decreases expression |
ISO |
casticin results in decreased expression of LPL mRNA |
CTD |
PMID:27862857 |
|
NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496
|
|
G |
Lrp5 |
LDL receptor related protein 5 |
increases expression |
ISO |
casticin results in increased expression of LRP5 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094
|
|
G |
Ltv1 |
LTV1 ribosome biogenesis factor |
decreases expression |
ISO |
casticin results in decreased expression of LTV1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:7,323,043...7,335,766
Ensembl chr 1:7,323,040...7,335,936
|
|
G |
Maf |
MAF bZIP transcription factor |
decreases expression |
ISO |
casticin results in decreased expression of MAF mRNA |
CTD |
PMID:28444820 |
|
NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748
|
|
G |
Magoh |
mago homolog, exon junction complex subunit |
decreases expression |
ISO |
casticin results in decreased expression of MAGOH mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:127,480,465...127,487,617
Ensembl chr 5:127,480,485...127,487,603
|
|
G |
Map3k7 |
mitogen activated protein kinase kinase kinase 7 |
increases expression |
ISO |
casticin results in increased expression of MAP3K7 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416
|
|
G |
Mapre2 |
microtubule-associated protein, RP/EB family, member 2 |
increases expression |
ISO |
casticin results in increased expression of MAPRE2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:14,814,149...15,780,290
|
|
G |
Mark3 |
microtubule affinity regulating kinase 3 |
decreases expression |
ISO |
casticin results in decreased expression of MARK3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:136,040,957...136,129,780
Ensembl chr 6:136,041,777...136,129,661
|
|
G |
Max |
MYC associated factor X |
decreases expression |
ISO |
casticin results in decreased expression of MAX mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:99,984,260...100,011,460
Ensembl chr 6:99,984,260...100,011,388
|
|
G |
Mbp |
myelin basic protein |
increases expression |
ISO |
casticin results in increased expression of MBP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310
|
|
G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression |
ISO |
casticin results in decreased expression of MCL1 protein |
CTD |
PMID:27862857 |
|
NCBI chr 2:197,786,212...197,788,992
|
|
G |
Mdc1 |
mediator of DNA damage checkpoint 1 |
increases expression |
ISO |
casticin results in increased expression of MDC1 protein |
CTD |
PMID:29098808 |
|
NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831
|
|
G |
Mecom |
MDS1 and EVI1 complex locus |
decreases expression |
ISO |
casticin results in decreased expression of MECOM mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769
|
|
G |
Mest |
mesoderm specific transcript |
increases expression |
ISO |
casticin results in increased expression of MEST mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:58,052,786...58,063,227
Ensembl chr 4:58,053,041...58,063,138
|
|
G |
Mettl3 |
methyltransferase-like 3 |
decreases expression |
ISO |
casticin results in decreased expression of METTL3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr15:28,710,299...28,721,491
Ensembl chr15:28,710,300...28,721,127
|
|
G |
Mir148a |
microRNA 148a |
increases expression multiple interactions |
ISO |
casticin results in increased expression of MIR148A mRNA casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin affects the reaction [MIR148A mRNA results in increased expression of MIR148A mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA affects the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA] |
CTD |
PMID:32268151 |
|
NCBI chr 4:81,013,269...81,013,365
Ensembl chr 4:81,013,269...81,013,365
|
|
G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
casticin results in decreased expression of MMP2 mRNA casticin results in decreased expression of MMP2 protein |
CTD |
PMID:27862857 PMID:28444820 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
|
|
G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression |
ISO |
casticin results in decreased expression of MMP9 protein |
CTD |
PMID:28444820 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
|
|
G |
Mplkip |
M-phase specific PLK1 interacting protein |
decreases expression |
ISO |
casticin results in decreased expression of MPLKIP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr17:49,955,060...49,990,982
Ensembl chr17:49,955,060...49,991,059
|
|
G |
mrpl9 |
mitochondrial ribosomal protein L9 |
increases expression |
ISO |
casticin results in increased expression of MRPL9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:195,684,750...195,689,470
Ensembl chr 2:195,684,210...195,689,052
|
|
G |
Muc13 |
mucin 13, cell surface associated |
increases expression |
ISO |
casticin results in increased expression of MUC13 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr11:70,185,757...70,223,012
Ensembl chr11:70,185,757...70,211,701
|
|
G |
Myd88 |
MYD88, innate immune signal transduction adaptor |
increases expression |
ISO |
casticin results in increased expression of MYD88 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841
|
|
G |
Myo7a |
myosin VIIA |
increases expression |
ISO |
casticin results in increased expression of MYO7A mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:163,001,313...163,071,545
Ensembl chr 1:163,001,875...163,071,508
|
|
G |
Nanog |
Nanog homeobox |
multiple interactions decreases expression |
ISO |
casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA] |
CTD |
PMID:32268151 |
|
NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268
|
|
G |
Nars1 |
asparaginyl-tRNA synthetase 1 |
decreases expression |
ISO |
casticin results in decreased expression of NARS mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569
|
|
G |
Ndufs4 |
NADH:ubiquinone oxidoreductase subunit S4 |
decreases expression |
ISO |
casticin results in decreased expression of NDUFS4 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203
|
|
G |
Nfkb1 |
nuclear factor kappa B subunit 1 |
decreases expression |
ISO |
casticin results in decreased expression of NFKB1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689
|
|
G |
Nfkb2 |
nuclear factor kappa B subunit 2 |
decreases expression |
ISO |
casticin results in decreased expression of NFKB2 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
decreases expression |
ISO |
casticin results in decreased expression of NFKBIA mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
|
|
G |
Nfkbib |
NFKB inhibitor beta |
decreases expression |
ISO |
casticin results in decreased expression of NFKBIB mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845
|
|
G |
Nfkbid |
NFKB inhibitor delta |
decreases expression |
ISO |
casticin results in decreased expression of NFKBID mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615
|
|
G |
Nfkbie |
NFKB inhibitor epsilon |
decreases expression |
ISO |
casticin results in decreased expression of NFKBIE mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240
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G |
Nfx1 |
nuclear transcription factor, X-box binding 1 |
increases expression |
ISO |
casticin results in increased expression of NFX1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:57,290,916...57,348,720
Ensembl chr 5:57,291,156...57,348,720
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G |
Nkd1 |
NKD inhibitor of WNT signaling pathway 1 |
increases expression |
ISO |
casticin results in increased expression of NKD1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr19:19,434,720...19,509,087
Ensembl chr19:19,436,333...19,509,087
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G |
Nme9 |
NME/NM23 family member 9 |
increases expression |
ISO |
casticin results in increased expression of NME9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:107,698,612...107,720,758
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G |
Nmt1 |
N-myristoyltransferase 1 |
decreases expression |
ISO |
casticin results in decreased expression of NMT1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:91,126,689...91,160,721
Ensembl chr10:91,126,689...91,160,720
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G |
Nol4l |
nucleolar protein 4-like |
decreases expression |
ISO |
casticin results in decreased expression of NOL4L mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:148,905,677...148,940,426
Ensembl chr 3:148,909,826...148,932,878
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G |
Nop58 |
NOP58 ribonucleoprotein |
decreases expression |
ISO |
casticin results in decreased expression of NOP58 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 9:66,495,881...66,520,521
Ensembl chr 9:66,495,832...66,519,788
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G |
Npas3 |
neuronal PAS domain protein 3 |
decreases expression |
ISO |
casticin results in decreased expression of NPAS3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:74,081,995...74,913,025
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|
G |
Nrg3 |
neuregulin 3 |
decreases expression |
ISO |
casticin results in decreased expression of NRG3 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr16:15,763,031...16,932,208
Ensembl chr16:15,764,632...15,798,974
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G |
Nup205 |
nucleoporin 205 |
decreases expression |
ISO |
casticin results in decreased expression of NUP205 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:62,703,779...62,773,931
Ensembl chr 4:62,703,779...62,773,923
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G |
Nup37 |
nucleoporin 37 |
decreases expression |
ISO |
casticin results in decreased expression of NUP37 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:28,715,299...28,750,978
Ensembl chr 7:28,701,690...28,743,326
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G |
Olig2 |
oligodendrocyte transcription factor 2 |
decreases expression |
ISO |
casticin results in decreased expression of OLIG2 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890
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G |
Orc5 |
origin recognition complex, subunit 5 |
decreases expression |
ISO |
casticin results in decreased expression of ORC5 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:9,160,050...9,223,998
Ensembl chr 4:9,160,067...9,223,997
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|
G |
Otub2 |
OTU deubiquitinase, ubiquitin aldehyde binding 2 |
decreases expression |
ISO |
casticin results in decreased expression of OTUB2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083
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G |
P2rx7 |
purinergic receptor P2X 7 |
increases expression |
ISO |
casticin results in increased expression of P2RX7 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042
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G |
Paip1 |
poly(A) binding protein interacting protein 1 |
decreases expression |
ISO |
casticin results in decreased expression of PAIP1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:52,300,921...52,328,212
Ensembl chr 2:52,301,798...52,328,205
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G |
Pak3 |
p21 (RAC1) activated kinase 3 |
decreases expression |
ISO |
casticin results in decreased expression of PAK3 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr X:114,784,452...115,042,683
Ensembl chr X:114,929,029...115,036,669
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|
G |
Papola |
poly (A) polymerase alpha |
decreases expression |
ISO |
casticin results in decreased expression of PAPOLA mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:129,609,068...129,662,002
Ensembl chr 6:129,609,074...129,661,531
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G |
Pcdha1 |
protocadherin alpha 1 |
increases expression |
ISO |
casticin results in increased expression of PCDHA1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr18:29,951,094...30,215,896
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G |
Phf10 |
PHD finger protein 10 |
decreases expression |
ISO |
casticin results in decreased expression of PHF10 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:56,951,516...56,967,893
Ensembl chr 1:56,951,518...56,967,895
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G |
Picalm |
phosphatidylinositol binding clathrin assembly protein |
decreases expression |
ISO |
casticin results in decreased expression of PICALM mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425
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G |
Plau |
plasminogen activator, urokinase |
decreases expression |
ISO |
casticin results in decreased expression of PLAU protein |
CTD |
PMID:28444820 |
|
NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819
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|
G |
Pmp22 |
peripheral myelin protein 22 |
increases expression |
ISO |
casticin results in increased expression of PMP22 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583
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G |
Pou5f1 |
POU class 5 homeobox 1 |
multiple interactions decreases expression |
ISO |
casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA] |
CTD |
PMID:32268151 |
|
NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
decreases expression |
ISO |
casticin results in decreased expression of PPARD mRNA |
CTD |
PMID:27862857 |
|
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
increases expression |
ISO |
casticin results in increased expression of PPARG mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Ppargc1a |
PPARG coactivator 1 alpha |
decreases expression |
ISO |
casticin results in decreased expression of PPARGC1A mRNA |
CTD |
PMID:28444820 |
|
NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009
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|
G |
Ppp1r11 |
protein phosphatase 1, regulatory (inhibitor) subunit 11 |
decreases expression |
ISO |
casticin results in decreased expression of PPP1R11 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr20:2,094,931...2,098,438
Ensembl chr20:2,094,931...2,098,433
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G |
Ppp6r3 |
protein phosphatase 6, regulatory subunit 3 |
decreases expression |
ISO |
casticin results in decreased expression of PPP6R3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:218,695,738...218,810,139
Ensembl chr 1:218,695,738...218,810,135
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G |
Prkar2b |
protein kinase cAMP-dependent type II regulatory subunit beta |
decreases expression |
ISO |
casticin results in decreased expression of PRKAR2B mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383
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|
G |
Prkdc |
protein kinase, DNA-activated, catalytic subunit |
decreases expression |
ISO |
casticin results in decreased expression of PRKDC protein |
CTD |
PMID:29098808 |
|
NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871
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|
G |
Prss44 |
serine protease 44 |
increases expression |
ISO |
casticin results in increased expression of PRSS44 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:119,083,900...119,097,707
Ensembl chr 8:119,083,900...119,097,707
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|
G |
Ptk2 |
protein tyrosine kinase 2 |
decreases expression |
ISO |
casticin results in decreased expression of PTK2 protein |
CTD |
PMID:28444820 |
|
NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119
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G |
Ptpra |
protein tyrosine phosphatase, receptor type, A |
increases expression |
ISO |
casticin results in increased expression of PTPRA mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863
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|
G |
Ptprd |
protein tyrosine phosphatase, receptor type, D |
decreases expression |
ISO |
casticin results in decreased expression of PTPRD mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202
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|
G |
Ptprf |
protein tyrosine phosphatase, receptor type, F |
decreases expression |
ISO |
casticin results in decreased expression of PTPRF mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927
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G |
Qk |
quaking |
decreases expression |
ISO |
casticin results in decreased expression of QK mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:50,983,647...51,050,692
|
|
G |
Rapgef4 |
Rap guanine nucleotide exchange factor 4 |
decreases expression |
ISO |
casticin results in decreased expression of RAPGEF4 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038
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G |
Rars1 |
arginyl-tRNA synthetase 1 |
decreases expression |
ISO |
casticin results in decreased expression of RARS mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:20,633,630...20,658,074
Ensembl chr10:20,633,632...20,658,100
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|
G |
Rbmx2 |
RNA binding motif protein, X-linked 2 |
decreases expression |
ISO |
casticin results in decreased expression of RBMX2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr X:135,550,931...135,558,440
Ensembl chr X:135,550,834...135,558,440
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|
G |
Rcor3 |
REST corepressor 3 |
decreases expression |
ISO |
casticin results in decreased expression of RCOR3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr13:110,822,149...110,864,469
Ensembl chr13:110,822,150...110,864,469
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
decreases expression |
ISO |
casticin results in decreased expression of RELA protein |
CTD |
PMID:28444820 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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|
G |
Rexo2 |
RNA exonuclease 2 |
decreases expression |
ISO |
casticin results in decreased expression of REXO2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:52,802,604...52,814,321
Ensembl chr 8:52,802,595...52,814,321
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|
G |
Rhoa |
ras homolog family member A |
decreases expression |
ISO |
casticin results in decreased expression of RHOA protein |
CTD |
PMID:28444820 |
|
NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
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|
G |
Rpl22l1 |
ribosomal protein L22 like 1 |
decreases expression |
ISO |
casticin results in decreased expression of RPL22L1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:115,362,799...115,364,735
Ensembl chr 2:115,362,799...115,364,729
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|
G |
S100a13 |
S100 calcium binding protein A13 |
increases expression |
ISO |
casticin results in increased expression of S100A13 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:189,906,022...189,912,516
Ensembl chr 2:189,906,022...189,912,516
|
|
G |
Scn1b |
sodium voltage-gated channel beta subunit 1 |
increases expression |
ISO |
casticin results in increased expression of SCN1B mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719
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|
G |
Slc31a1 |
solute carrier family 31 member 1 |
increases expression |
ISO |
casticin results in increased expression of SLC31A1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358
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|
G |
Slc6a9 |
solute carrier family 6 member 9 |
decreases expression |
ISO |
casticin results in decreased expression of SLC6A9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
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|
G |
Smad1 |
SMAD family member 1 |
increases expression |
ISO |
casticin results in increased expression of SMAD1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684
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G |
Smad3 |
SMAD family member 3 |
increases expression |
ISO |
casticin results in increased expression of SMAD3 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
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|
G |
Snrpg |
small nuclear ribonucleoprotein polypeptide G |
decreases expression |
ISO |
casticin results in decreased expression of SNRPG mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:118,167,267...118,174,846
Ensembl chr 4:118,167,294...118,174,842
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|
G |
Snw1 |
SNW domain containing 1 |
decreases expression |
ISO |
casticin results in decreased expression of SNW1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782
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|
G |
Sos1 |
SOS Ras/Rac guanine nucleotide exchange factor 1 |
decreases expression |
ISO |
casticin results in decreased expression of SOS1 protein |
CTD |
PMID:28444820 |
|
NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996
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G |
Sparc |
secreted protein acidic and cysteine rich |
decreases expression increases expression |
ISO |
casticin results in decreased expression of SPARC mRNA casticin results in increased expression of SPARC mRNA |
CTD |
PMID:27862857 PMID:28444820 |
|
NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185
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G |
Sparcl1 |
SPARC like 1 |
increases expression |
ISO |
casticin results in increased expression of SPARCL1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr14:6,994,261...7,025,309
Ensembl chr14:6,994,190...7,025,308
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|
G |
St13 |
ST13, Hsp70 interacting protein |
increases expression |
ISO |
casticin results in increased expression of ST13 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731
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|
G |
St3gal3 |
ST3 beta-galactoside alpha-2,3-sialyltransferase 3 |
decreases expression |
ISO |
casticin results in decreased expression of ST3GAL3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:136,765,309...136,965,642
Ensembl chr 5:136,766,208...136,965,191
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G |
Strbp |
spermatid perinuclear RNA binding protein |
decreases expression |
ISO |
casticin results in decreased expression of STRBP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270
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|
G |
Sugp1 |
SURP and G patch domain containing 1 |
decreases expression |
ISO |
casticin results in decreased expression of SUGP1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr16:21,100,923...21,131,795
Ensembl chr16:21,100,924...21,131,795
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|
G |
Syncrip |
synaptotagmin binding, cytoplasmic RNA interacting protein |
decreases expression |
ISO |
casticin results in decreased expression of SYNCRIP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342
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|
G |
Syt9 |
synaptotagmin 9 |
decreases expression |
ISO |
casticin results in decreased expression of SYT9 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:171,592,703...171,769,780
Ensembl chr 1:171,592,797...171,769,780
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|
G |
Tab2 |
TGF-beta activated kinase 1/MAP3K7 binding protein 2 |
decreases expression |
ISO |
casticin results in decreased expression of TAB2 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 1:1,999,574...2,017,574
Ensembl chr 1:1,999,596...2,073,896
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|
G |
Tcf7 |
transcription factor 7 |
decreases expression |
ISO |
casticin results in decreased expression of TCF7 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:37,616,033...37,646,027
Ensembl chr10:37,617,279...37,645,802
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|
G |
Thra |
thyroid hormone receptor alpha |
decreases expression |
ISO |
casticin results in decreased expression of THRA mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933
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|
G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
casticin results in increased expression of TIMP2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
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|
G |
Tlk2 |
tousled-like kinase 2 |
decreases expression |
ISO |
casticin results in decreased expression of TLK2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:93,410,181...93,507,277
Ensembl chr10:93,415,399...93,507,277
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|
G |
Tlr4 |
toll-like receptor 4 |
decreases expression |
ISO |
casticin results in decreased expression of TLR4 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052
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|
G |
Tmbim4 |
transmembrane BAX inhibitor motif containing 4 |
increases expression |
ISO |
casticin results in increased expression of TMBIM4 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 7:64,987,859...65,002,447
Ensembl chr 7:64,987,859...65,002,455
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|
G |
Tmem45b |
transmembrane protein 45b |
increases expression |
ISO |
casticin results in increased expression of TMEM45B mRNA |
CTD |
PMID:27862857 |
|
NCBI chr 8:32,563,872...32,609,212
Ensembl chr 8:32,563,874...32,609,212
|
|
G |
Tmsb10 |
thymosin, beta 10 |
increases expression |
ISO |
casticin results in increased expression of TMSB10 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:100,882,216...100,883,303
Ensembl chr 4:100,882,216...100,883,275
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|
G |
Tnfsf10 |
TNF superfamily member 10 |
increases expression |
ISO |
casticin results in increased expression of TNFSF10 protein |
CTD |
PMID:27862857 |
|
NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899
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|
G |
Tnpo1 |
transportin 1 |
decreases expression |
ISO |
casticin results in decreased expression of TNPO1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:29,056,219...29,126,882
Ensembl chr 2:29,056,219...29,121,104
|
|
G |
Tor1aip2 |
torsin 1A interacting protein 2 |
decreases expression |
ISO |
casticin results in decreased expression of TOR1AIP2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr13:73,704,088...73,735,339
Ensembl chr13:73,708,815...73,735,339 Ensembl chr13:73,708,815...73,735,339
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|
G |
Tp53 |
tumor protein p53 |
increases expression decreases expression |
ISO |
casticin results in increased expression of TP53 protein modified form casticin results in decreased expression of TP53 protein |
CTD |
PMID:29098808 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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|
G |
Tpi1 |
triosephosphate isomerase 1 |
increases expression |
ISO |
casticin results in increased expression of TPI1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905
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|
G |
Tpra1 |
transmembrane protein adipocyte associated 1 |
increases expression |
ISO |
casticin results in increased expression of TPRA1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:120,843,374...120,854,534
Ensembl chr 4:120,843,453...120,854,529
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G |
Tra2b |
transformer 2 beta homolog |
decreases expression |
ISO |
casticin results in decreased expression of TRA2B mRNA |
CTD |
PMID:28444820 |
|
NCBI chr11:82,373,828...82,392,208
Ensembl chr11:82,373,870...82,392,083
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G |
Trap1 |
TNF receptor-associated protein 1 |
increases expression |
ISO |
casticin results in increased expression of TRAP1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681
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G |
Trio |
trio Rho guanine nucleotide exchange factor |
increases expression |
ISO |
casticin results in increased expression of TRIO mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:80,471,398...80,769,313
Ensembl chr 2:80,473,202...80,667,481
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G |
Ube2d3 |
ubiquitin-conjugating enzyme E2D 3 |
decreases expression |
ISO |
casticin results in decreased expression of UBE2D3 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:240,626,198...240,655,874
Ensembl chr 2:240,627,436...240,655,246
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G |
Ube2f |
ubiquitin-conjugating enzyme E2F (putative) |
decreases expression |
ISO |
casticin results in decreased expression of UBE2F mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 9:98,394,112...98,428,684
Ensembl chr 9:98,398,128...98,428,128
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G |
Ube2w |
ubiquitin-conjugating enzyme E2W |
decreases expression |
ISO |
casticin results in decreased expression of UBE2W mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 5:29,798,845...29,812,777
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G |
Vegfa |
vascular endothelial growth factor A |
decreases expression |
ISO |
casticin results in decreased expression of VEGFA mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Vezf1 |
vascular endothelial zinc finger 1 |
decreases expression |
ISO |
casticin results in decreased expression of VEZF1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:75,365,763...75,382,014
Ensembl chr10:75,365,822...75,381,555
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G |
Vim |
vimentin |
decreases expression increases expression |
ISO |
casticin results in decreased expression of VIM mRNA casticin results in increased expression of VIM mRNA |
CTD |
PMID:27862857 PMID:28444820 |
|
NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212
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G |
Vldlr |
very low density lipoprotein receptor |
decreases expression |
ISO |
casticin results in decreased expression of VLDLR mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205
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G |
Wac |
WW domain containing adaptor with coiled-coil |
decreases expression |
ISO |
casticin results in decreased expression of WAC mRNA |
CTD |
PMID:28444820 |
|
NCBI chr17:60,887,606...60,946,630
Ensembl chr17:60,888,017...60,946,426
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G |
Wee1 |
WEE1 G2 checkpoint kinase |
decreases expression |
ISO |
casticin results in decreased expression of WEE1 protein |
CTD |
PMID:29098808 |
|
NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361
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G |
Wnt5a |
Wnt family member 5A |
decreases expression |
ISO |
casticin results in decreased expression of WNT5A mRNA |
CTD |
PMID:27862857 |
|
NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860
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G |
Wsb1 |
WD repeat and SOCS box-containing 1 |
decreases expression |
ISO |
casticin results in decreased expression of WSB1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987
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G |
Wtap |
WT1 associated protein |
decreases expression |
ISO |
casticin results in decreased expression of WTAP mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:47,942,500...47,967,633
Ensembl chr 1:47,942,500...47,967,631
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G |
Xbp1 |
X-box binding protein 1 |
increases expression |
ISO |
casticin results in increased expression of XBP1 mRNA |
CTD |
PMID:27862857 |
|
NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145
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G |
Xiap |
X-linked inhibitor of apoptosis |
decreases expression |
ISO |
casticin results in decreased expression of XIAP protein |
CTD |
PMID:29098808 |
|
NCBI chr X:128,409,425...128,455,786
Ensembl chr X:128,409,472...128,453,000
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|
G |
Ywhab |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta |
increases expression |
ISO |
casticin results in increased expression of YWHAB protein |
CTD |
PMID:29098808 |
|
NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931
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G |
Ywhag |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma |
decreases expression |
ISO |
casticin results in decreased expression of YWHAG mRNA |
CTD |
PMID:28444820 |
|
NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883
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G |
Zbtb18 |
zinc finger and BTB domain containing 18 |
decreases expression |
ISO |
casticin results in decreased expression of ZBTB18 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr13:95,582,234...95,593,316
Ensembl chr13:95,589,668...95,591,236
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G |
Zfhx4 |
zinc finger homeobox 4 |
decreases expression |
ISO |
casticin results in decreased expression of ZFHX4 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:98,423,565...98,610,368
Ensembl chr 2:98,423,569...98,610,368
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G |
Zfp384 |
zinc finger protein 384 |
decreases expression |
ISO |
casticin results in decreased expression of ZFP384 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 4:157,523,083...157,552,606
Ensembl chr 4:157,523,110...157,552,596
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|
G |
Zfp711 |
zinc finger protein 711 |
decreases expression |
ISO |
casticin results in decreased expression of ZFP711 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr X:84,062,363...84,095,888
Ensembl chr X:84,064,427...84,096,617
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|
G |
Zfr |
zinc finger RNA binding protein |
decreases expression |
ISO |
casticin results in decreased expression of ZFR mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:62,150,251...62,213,048
Ensembl chr 2:62,150,251...62,213,048
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G |
Zkscan1 |
zinc finger with KRAB and SCAN domains 1 |
increases expression |
ISO |
casticin results in increased expression of ZKSCAN1 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr12:19,231,092...19,247,393
Ensembl chr12:19,231,092...19,247,387
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G |
Zscan2 |
zinc finger and SCAN domain containing 2 |
increases expression |
ISO |
casticin results in increased expression of ZSCAN2 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 1:142,679,308...142,695,232
Ensembl chr 1:142,679,345...142,695,475
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G |
Zswim6 |
zinc finger, SWIM-type containing 6 |
increases expression |
ISO |
casticin results in increased expression of ZSWIM6 mRNA |
CTD |
PMID:28444820 |
|
NCBI chr 2:38,978,042...39,042,886
Ensembl chr 2:38,979,865...39,007,976
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
EXP |
[5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein |
CTD |
PMID:21554863 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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|
G |
Bcl2l1 |
Bcl2-like 1 |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] |
CTD |
PMID:21554863 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] |
CTD |
PMID:21554863 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] |
CTD |
PMID:24134915 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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|
G |
Ccnd1 |
cyclin D1 |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] |
CTD |
PMID:21554863 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
|
|
G |
Csnk2b |
casein kinase 2 beta |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] |
CTD |
PMID:21554863 |
|
NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112
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|
G |
Ctnnb1 |
catenin beta 1 |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] |
CTD |
PMID:21554863 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases activity |
ISO |
5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein] 5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein |
CTD |
PMID:15661813 PMID:15905203 PMID:16484233 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
|
|
G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
multiple interactions decreases activity |
ISO |
5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein] 5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein |
CTD |
PMID:15905203 PMID:16484233 PMID:16530937 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
multiple interactions |
EXP |
5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] |
CTD |
PMID:21554863 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] |
CTD |
PMID:24134915 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] |
CTD |
PMID:24134915 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] |
CTD |
PMID:21554863 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] |
CTD |
PMID:21554863 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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|
G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] |
CTD |
PMID:21554863 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
|
|
G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
[5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein |
CTD |
PMID:21554863 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
|
|
G |
Wnt3a |
Wnt family member 3A |
multiple interactions |
EXP |
5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] |
CTD |
PMID:21554863 |
|
NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
chrysosplenetin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
|
|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
affects activity |
ISO |
chrysosplenetin affects the activity of CYP3A4 protein |
CTD |
PMID:29753067 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity increases metabolic processing increases expression |
ISO |
cirsiliol results in decreased activity of CYP1A1 protein CYP1A1 protein results in increased metabolism of cirsiliol cirsiliol results in increased expression of CYP1A1 mRNA |
CTD |
PMID:19601638 PMID:21482471 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression increases metabolic processing decreases activity |
ISO |
cirsiliol results in increased expression of CYP1B1 mRNA CYP1B1 protein results in increased metabolism of cirsiliol cirsiliol results in decreased activity of CYP1B1 protein |
CTD |
PMID:19601638 PMID:21482471 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP1A1 protein |
CTD |
PMID:10781868 PMID:21482471 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP1A2 protein |
CTD |
PMID:28867436 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP1B1 protein |
CTD |
PMID:10781868 PMID:21482471 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
|
|
G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP2C19 protein |
CTD |
PMID:28867436 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
|
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G |
Cyp2c79 |
cytochrome P450, family 2, subfamily c, polypeptide 79 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP2C8 protein |
CTD |
PMID:28867436 |
|
NCBI chr 1:147,236,480...147,307,988
|
|
G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
decreases activity |
ISO |
diosmetin results in decreased activity of CYP2E1 protein |
CTD |
PMID:28867436 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] |
CTD |
PMID:18191104 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
|
|
G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] |
CTD |
PMID:18191104 |
|
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
|
|
G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] |
CTD |
PMID:16934226 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:16934226 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
|
|
G |
Pkm |
pyruvate kinase M1/2 |
increases activity |
ISO |
diosmetin results in increased activity of PKM protein |
CTD |
PMID:25388478 |
|
NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
|
|
G |
Slc16a1 |
solute carrier family 16 member 1 |
multiple interactions |
EXP |
[diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate |
CTD |
PMID:17108059 |
|
NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554
|
|
G |
Slc22a1 |
solute carrier family 22 member 1 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] |
CTD |
PMID:28867436 |
|
NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655
|
|
G |
Slco1a4 |
solute carrier organic anion transporter family, member 1a4 |
multiple interactions |
ISO |
diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] |
CTD |
PMID:28867436 |
|
NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163
|
|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:16934226 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
|
|
|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
Diosmin binds to and results in increased activity of AHR protein |
CTD |
PMID:14644660 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
|
|
G |
Bad |
BCL2-associated agonist of cell death |
multiple interactions |
EXP |
Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] |
CTD |
PMID:21477647 |
|
NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453
|
|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] |
CTD |
PMID:32061149 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
EXP ISO |
[Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein] |
CTD |
PMID:21477647 PMID:32061149 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein] |
CTD |
PMID:21477647 PMID:23665045 PMID:32061149 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp7 |
caspase 7 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774
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G |
Casp9 |
caspase 9 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] |
CTD |
PMID:22056647 PMID:23665045 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cyp2e1 |
cytochrome P450, family 2, subfamily e, polypeptide 1 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] |
CTD |
PMID:32061149 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Mki67 |
marker of proliferation Ki-67 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] |
CTD |
PMID:23665045 |
|
NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] |
CTD |
PMID:23665045 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] |
CTD |
PMID:32061149 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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|
G |
Pcna |
proliferating cell nuclear antigen |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] |
CTD |
PMID:23665045 |
|
NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570
|
|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] |
CTD |
PMID:32061149 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
CTD |
PMID:21477647 PMID:23665045 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions |
EXP |
Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] |
CTD |
PMID:23665045 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Xdh |
xanthine dehydrogenase |
multiple interactions |
EXP ISO |
Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein] Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein] |
CTD |
PMID:23665045 PMID:32061149 |
|
NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA] |
CTD |
PMID:21565208 |
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NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases activity multiple interactions |
ISO |
eupatilin results in increased activity of CYP3A4 protein [[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam |
CTD |
PMID:31756459 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA] |
CTD |
PMID:21565208 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA] |
CTD |
PMID:21565208 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:21565208 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] |
CTD |
PMID:21565208 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] |
CTD |
PMID:21565208 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein] |
CTD |
PMID:21565208 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA] |
CTD |
PMID:21565208 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases response to substance increases metabolic processing decreases activity increases expression |
ISO |
CYP1A1 protein results in increased susceptibility to eupatorin CYP1A1 protein results in increased metabolism of eupatorin analog eupatorin analog results in decreased activity of CYP1A1 protein eupatorin results in increased expression of CYP1A1 mRNA |
CTD |
PMID:18454852 PMID:19601638 PMID:21482471 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing increases expression decreases activity |
ISO |
CYP1B1 protein results in increased metabolism of eupatorin analog eupatorin results in increased expression of CYP1B1 mRNA eupatorin results in decreased activity of CYP1B1 protein |
CTD |
PMID:19601638 PMID:21482471 |
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NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
eupatorin results in decreased activity of CYP2C19 protein |
CTD |
PMID:21093571 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G |
Cyp2d4 |
cytochrome P450, family 2, subfamily d, polypeptide 4 |
decreases activity |
ISO |
eupatorin results in decreased activity of CYP2D6 protein |
CTD |
PMID:21276781 |
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NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
decreases activity |
ISO |
eupatorin results in decreased activity of CYP3A4 protein |
CTD |
PMID:21276781 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
gardenin B results in decreased expression of BCL2 protein |
CTD |
PMID:27423764 |
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NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp2 |
caspase 2 |
multiple interactions |
ISO |
gardenin B results in increased cleavage of and results in increased activity of CASP2 protein |
CTD |
PMID:27423764 |
|
NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
gardenin B results in increased cleavage of and results in increased activity of CASP3 protein |
CTD |
PMID:27423764 |
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NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
gardenin B results in increased cleavage of and results in increased activity of CASP8 protein |
CTD |
PMID:27423764 |
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NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
multiple interactions |
ISO |
gardenin B results in increased cleavage of and results in increased activity of CASP9 protein |
CTD |
PMID:27423764 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
gardenin B results in increased cleavage of PARP1 protein |
CTD |
PMID:27423764 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing decreases activity |
ISO |
CYP1A1 protein results in increased metabolism of genkwanin genkwanin results in decreased activity of CYP1A1 protein |
CTD |
PMID:19666078 PMID:21482471 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of genkwanin |
CTD |
PMID:19666078 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing multiple interactions |
ISO |
CYP1B1 protein results in increased metabolism of genkwanin [CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin |
CTD |
PMID:19666078 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein] ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein] |
CTD |
PMID:25968939 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein] ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein] |
CTD |
PMID:25968939 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
multiple interactions |
ISO |
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] |
CTD |
PMID:25968939 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Ftl1 |
ferritin light chain 1 |
decreases expression |
ISO |
ginkgetin results in decreased expression of FTL1 protein ginkgetin results in decreased expression of FTL protein |
CTD |
PMID:25968939 |
|
NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829
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G |
Tfrc |
transferrin receptor |
increases expression |
ISO |
ginkgetin results in increased expression of TFRC protein |
CTD |
PMID:25968939 |
|
NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223
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G |
Th |
tyrosine hydroxylase |
multiple interactions |
ISO |
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] |
CTD |
PMID:25968939 |
|
NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287
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G |
Adipoq |
adiponectin, C1Q and collagen domain containing |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] |
CTD |
PMID:30055130 |
|
NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488
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G |
Cebpa |
CCAAT/enhancer binding protein alpha |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] |
CTD |
PMID:30055130 |
|
NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164
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G |
Ins2 |
insulin 2 |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] |
CTD |
PMID:30055130 |
|
NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034
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G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions |
EXP |
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22759588 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions |
EXP |
hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] |
CTD |
PMID:22759588 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
|
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions |
ISO |
hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] |
CTD |
PMID:30055130 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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|
G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
multiple interactions decreases activity |
EXP |
[hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate |
CTD |
PMID:32259555 |
|
NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
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G |
Syn1 |
synapsin I |
affects response to substance |
ISO |
SYN1 protein affects the susceptibility to hispidulin |
CTD |
PMID:22759588 |
|
NCBI chr X:1,321,315...1,379,202
Ensembl chr X:1,321,315...1,379,198
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|
|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases transport increases expression |
ISO |
ABCB1 protein results in increased transport of 3-methylquercetin 3-methylquercetin results in increased expression of ABCB1 mRNA |
CTD |
PMID:15969930 PMID:26238175 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
decreases activity |
ISO |
3-methylquercetin results in decreased activity of ABCC1 protein |
CTD |
PMID:15670588 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Acta2 |
actin alpha 2, smooth muscle |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein] |
CTD |
PMID:27151496 |
|
NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394
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|
G |
Agt |
angiotensinogen |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein] |
CTD |
PMID:17374653 |
|
NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433
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|
G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] |
CTD |
PMID:19794518 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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|
G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation multiple interactions |
ISO EXP |
3-methylquercetin results in decreased phosphorylation of AKT1 protein 3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein] |
CTD |
PMID:12826665 PMID:19222219 |
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NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein |
CTD |
PMID:22992727 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Bcl2l1 |
Bcl2-like 1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein |
CTD |
PMID:22992727 |
|
NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810
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G |
Casp3 |
caspase 3 |
decreases expression multiple interactions increases activity |
ISO EXP |
3-methylquercetin results in decreased expression of CASP3 protein 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein] 3-methylquercetin results in increased activity of CASP3 protein |
CTD |
PMID:12826665 PMID:19222219 PMID:22992727 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of CASP9 protein |
CTD |
PMID:22992727 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Cat |
catalase |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein |
CTD |
PMID:19222219 PMID:25716194 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Ccl3 |
C-C motif chemokine ligand 3 |
multiple interactions |
ISO |
[3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA |
CTD |
PMID:20579867 |
|
NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein |
CTD |
PMID:22992727 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Col1a1 |
collagen type I alpha 1 chain |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] |
CTD |
PMID:27151496 |
|
NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] |
CTD |
PMID:21329749 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of CYP1B1 mRNA |
CTD |
PMID:19794518 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases expression |
ISO |
3-methylquercetin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] |
CTD |
PMID:18436224 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
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G |
Esr1 |
estrogen receptor 1 |
affects binding |
ISO |
3-methylquercetin binds to ESR1 protein |
CTD |
PMID:14706564 |
|
NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796
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G |
Esr2 |
estrogen receptor 2 |
affects binding |
ISO |
3-methylquercetin binds to ESR2 protein |
CTD |
PMID:14706564 |
|
NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251
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G |
Gclc |
glutamate-cysteine ligase, catalytic subunit |
multiple interactions increases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein 3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein |
CTD |
PMID:24211276 PMID:25716194 |
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NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] |
CTD |
PMID:27151496 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions increases expression |
ISO EXP |
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein] [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein 3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein |
CTD |
PMID:24211276 PMID:24337631 PMID:25716194 PMID:27151496 |
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NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP ISO |
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein] 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA |
CTD |
PMID:20579867 PMID:23774260 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP ISO |
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein] 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA |
CTD |
PMID:20579867 PMID:23774260 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:19222219 |
|
NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mir155 |
microRNA 155 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA] |
CTD |
PMID:20579867 |
|
NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667
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G |
Ncf1 |
neutrophil cytosolic factor 1 |
multiple interactions |
EXP |
3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] |
CTD |
PMID:17374653 PMID:18436224 |
|
NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
affects response to substance multiple interactions affects localization increases activity |
ISO |
NFE2L2 protein affects the susceptibility to 3-methylquercetin 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein] 3-methylquercetin affects the localization of NFE2L2 protein [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide] |
CTD |
PMID:24211276 PMID:27151496 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:23774260 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA |
CTD |
PMID:16213685 PMID:18178435 PMID:18274639 PMID:20579867 PMID:23774260 |
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NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3] |
CTD |
PMID:16891912 |
|
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
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G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
ISO |
[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA |
CTD |
PMID:24211276 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
3-methylquercetin binds to and results in increased activity of NR1I2 protein 3-methylquercetin results in increased activity of NR1I2 protein |
CTD |
PMID:26238175 |
|
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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G |
Olr1 |
oxidized low density lipoprotein receptor 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1] |
CTD |
PMID:16891912 |
|
NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage |
ISO |
3-methylquercetin results in increased cleavage of PARP1 protein |
CTD |
PMID:22992727 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Pecam1 |
platelet and endothelial cell adhesion molecule 1 |
decreases expression |
ISO |
3-methylquercetin results in decreased expression of PECAM1 protein |
CTD |
PMID:22992727 |
|
NCBI chr10:94,850,971...94,913,202
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G |
Pon1 |
paraoxonase 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of PON1 mRNA |
CTD |
PMID:20228421 |
|
NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372
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G |
Pon2 |
paraoxonase 2 |
increases expression |
ISO |
3-methylquercetin results in increased expression of PON2 mRNA |
CTD |
PMID:19865538 |
|
NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119
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G |
Ppard |
peroxisome proliferator-activated receptor delta |
increases activity |
ISO |
3-methylquercetin results in increased activity of PPARD protein |
CTD |
PMID:22992727 |
|
NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333
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G |
Pparg |
peroxisome proliferator-activated receptor gamma |
multiple interactions increases expression |
ISO |
2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein 3-methylquercetin results in increased expression of PPARG protein |
CTD |
PMID:22992727 |
|
NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380
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G |
Prkcd |
protein kinase C, delta |
increases phosphorylation |
ISO |
3-methylquercetin results in increased phosphorylation of PRKCD protein |
CTD |
PMID:24211276 |
|
NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
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G |
Ptges |
prostaglandin E synthase |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] |
CTD |
PMID:21341175 |
|
NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions decreases activity |
ISO EXP |
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]] 3-methylquercetin results in decreased activity of PTGS2 protein 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein] |
CTD |
PMID:15292928 PMID:21341175 PMID:24337631 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] |
CTD |
PMID:18274639 PMID:20579867 PMID:23774260 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Serpine1 |
serpin family E member 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]] 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein] |
CTD |
PMID:27151496 |
|
NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482
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G |
Sesn2 |
sestrin 2 |
multiple interactions |
ISO |
[3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA |
CTD |
PMID:24211276 |
|
NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117
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|
G |
Smad2 |
SMAD family member 2 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] |
CTD |
PMID:27151496 |
|
NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078
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|
G |
Smad3 |
SMAD family member 3 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] |
CTD |
PMID:27151496 |
|
NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349
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G |
Tff1 |
trefoil factor 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of TFF1 mRNA |
CTD |
PMID:14706564 |
|
NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984
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G |
Tgfb1 |
transforming growth factor, beta 1 |
multiple interactions |
ISO |
3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] |
CTD |
PMID:27151496 |
|
NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP ISO |
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein] 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] |
CTD |
PMID:20579867 PMID:23774260 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tyr |
tyrosinase |
increases expression |
ISO |
3-methylquercetin results in increased expression of TYR protein |
CTD |
PMID:24853321 |
|
NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802
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G |
Tyrp1 |
tyrosinase-related protein 1 |
increases expression |
ISO |
3-methylquercetin results in increased expression of TYRP1 protein |
CTD |
PMID:24853321 |
|
NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
jaceosidin results in increased expression of and results in increased activity of BAX protein |
CTD |
PMID:27729209 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
jaceosidin results in increased activity of CASP3 protein |
CTD |
PMID:27729209 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cflar |
CASP8 and FADD-like apoptosis regulator |
decreases expression multiple interactions |
ISO |
jaceosidin results in decreased expression of CFLAR mRNA; jaceosidin results in decreased expression of CFLAR protein CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein] |
CTD |
PMID:27729209 |
|
NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251
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G |
Mcl1 |
MCL1 apoptosis regulator, BCL2 family member |
decreases expression multiple interactions |
ISO |
jaceosidin results in decreased expression of MCL1 mRNA; jaceosidin results in decreased expression of MCL1 protein MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] |
CTD |
PMID:27729209 |
|
NCBI chr 2:197,786,212...197,788,992
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases cleavage multiple interactions |
ISO |
jaceosidin results in increased cleavage of PARP1 protein benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein] |
CTD |
PMID:27729209 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO |
RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] |
CTD |
PMID:27729209 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Sp1 |
Sp1 transcription factor |
multiple interactions |
ISO |
SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] |
CTD |
PMID:27729209 |
|
NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629
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G |
Slc2a1 |
solute carrier family 2 member 1 |
decreases expression |
ISO |
kaempferide results in decreased expression of SLC2A1 mRNA |
CTD |
PMID:21865046 |
|
NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897
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G |
Vegfa |
vascular endothelial growth factor A |
increases expression |
ISO |
kaempferide results in increased expression of VEGFA mRNA |
CTD |
PMID:21865046 |
|
NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681
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G |
Ache |
acetylcholinesterase |
multiple interactions increases activity |
EXP |
4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [nevadensin results in increased activity of ACHE protein] |
CTD |
PMID:31034797 |
|
NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions |
ISO |
nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] |
CTD |
PMID:18955043 PMID:30790579 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcc1 |
ATP binding cassette subfamily C member 1 |
multiple interactions |
ISO |
nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon] |
CTD |
PMID:18955043 |
|
NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
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G |
Akt1 |
AKT serine/threonine kinase 1 |
multiple interactions |
ISO |
[nobiletin co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein |
CTD |
PMID:29687528 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Asns |
asparagine synthetase (glutamine-hydrolyzing) |
increases expression |
ISO EXP |
nobiletin results in increased expression of ASNS mRNA; nobiletin results in increased expression of ASNS protein |
CTD |
PMID:23321314 |
|
NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163
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G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions |
ISO |
nobiletin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] |
CTD |
PMID:29687528 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions |
ISO |
nobiletin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] |
CTD |
PMID:29687528 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of CCNA2 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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G |
Ccne2 |
cyclin E2 |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of CCNE2 mRNA |
CTD |
PMID:23321314 |
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NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406
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G |
Cd74 |
CD74 molecule |
decreases expression |
ISO |
nobiletin results in decreased expression of CD74 mRNA |
CTD |
PMID:18818744 |
|
NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing increases expression multiple interactions |
ISO |
CYP1A1 protein results in increased metabolism of nobiletin nobiletin results in increased expression of CYP1A1 protein nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] |
CTD |
PMID:20865247 PMID:22743247 |
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NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of nobiletin |
CTD |
PMID:22743247 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases expression |
ISO |
nobiletin results in increased expression of CYP1B1 mRNA |
CTD |
PMID:22743247 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
multiple interactions increases activity |
ISO |
[[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam |
CTD |
PMID:31756459 |
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NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Ddit3 |
DNA-damage inducible transcript 3 |
increases expression |
ISO EXP |
nobiletin results in increased expression of DDIT3 mRNA; nobiletin results in increased expression of DDIT3 protein |
CTD |
PMID:23321314 |
|
NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084
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G |
Depdc1 |
DEP domain containing 1 |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of DEPDC1 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr 2:264,704,738...264,738,265
Ensembl chr 2:264,704,769...264,738,257
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G |
E2f8 |
E2F transcription factor 8 |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of E2F8 mRNA |
CTD |
PMID:23321314 |
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NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
increases expression |
EXP |
nobiletin results in increased expression of FOS mRNA |
CTD |
PMID:24964900 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
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G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
EXP |
nobiletin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] |
CTD |
PMID:31777137 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
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G |
Grin1 |
glutamate ionotropic receptor NMDA type subunit 1 |
increases expression |
EXP |
nobiletin results in increased expression of GRIN1 mRNA |
CTD |
PMID:24964900 |
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NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663
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G |
Grin2a |
glutamate ionotropic receptor NMDA type subunit 2A |
increases expression |
EXP |
nobiletin results in increased expression of GRIN2A mRNA |
CTD |
PMID:24964900 |
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NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990
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G |
Grin2b |
glutamate ionotropic receptor NMDA type subunit 2B |
increases expression |
EXP |
nobiletin results in increased expression of GRIN2B mRNA |
CTD |
PMID:24964900 |
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NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873
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G |
H1f5 |
H1.5 linker histone, cluster member |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of H1-5 mRNA nobiletin results in decreased expression of H1F5 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981
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G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
nobiletin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein] |
CTD |
PMID:31777137 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein] |
CTD |
PMID:31777137 |
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NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL6 protein] |
CTD |
PMID:31777137 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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G |
Kif11 |
kinesin family member 11 |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of KIF11 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299
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G |
Mmp7 |
matrix metallopeptidase 7 |
decreases expression |
ISO |
nobiletin results in decreased expression of MMP7 mRNA; nobiletin results in decreased expression of MMP7 protein |
CTD |
PMID:15725655 |
|
NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
EXP |
nobiletin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein] |
CTD |
PMID:31777137 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Slc6a9 |
solute carrier family 6 member 9 |
increases expression |
ISO EXP |
nobiletin results in increased expression of SLC6A9 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697
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G |
Tmem116 |
transmembrane protein 116 |
increases expression |
ISO EXP |
nobiletin results in increased expression of TMEM116 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr12:40,537,261...40,618,805
Ensembl chr12:40,557,677...40,590,361
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
nobiletin inhibits the reaction [Acetaminophen results in increased expression of TNF protein] |
CTD |
PMID:31777137 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Trib3 |
tribbles pseudokinase 3 |
increases expression |
ISO EXP |
nobiletin results in increased expression of TRIB3 mRNA |
CTD |
PMID:23321314 |
|
NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571
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G |
Txnip |
thioredoxin interacting protein |
decreases expression |
ISO EXP |
nobiletin results in decreased expression of TXNIP mRNA; nobiletin results in decreased expression of TXNIP protein |
CTD |
PMID:23321314 |
|
NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases expression decreases activity multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein; diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA] |
CTD |
PMID:23470866 PMID:30790579 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
multiple interactions decreases activity |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCG2 protein |
CTD |
PMID:32305507 |
|
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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G |
Bcl2 |
BCL2, apoptosis regulator |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of BCL2 protein |
CTD |
PMID:19135124 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP3 protein |
CTD |
PMID:19135124 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Casp8 |
caspase 8 |
increases cleavage |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein |
CTD |
PMID:19135124 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Casp9 |
caspase 9 |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP9 protein |
CTD |
PMID:19135124 |
|
NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
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G |
Ccl2 |
C-C motif chemokine ligand 2 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL2 protein] |
CTD |
PMID:32464219 |
|
NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
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G |
Cdh5 |
cadherin 5 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of CDH5 protein] |
CTD |
PMID:32464219 |
|
NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
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G |
Chek2 |
checkpoint kinase 2 |
increases expression multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form] |
CTD |
PMID:23470866 |
|
NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
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G |
Ece1 |
endothelin converting enzyme 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein] |
CTD |
PMID:26694894 |
|
NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
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G |
Edn1 |
endothelin 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]] |
CTD |
PMID:26694894 |
|
NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
|
|
G |
Fasn |
fatty acid synthase |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]] |
CTD |
PMID:29476730 |
|
NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
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G |
Fos |
Fos proto-oncogene, AP-1 transcription factor subunit |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of FOS protein |
CTD |
PMID:22245252 |
|
NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
|
|
G |
Gpt |
glutamic--pyruvic transaminase |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of CXCL15 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of and affects the localization of HIF1A protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
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G |
Hmgb1 |
high mobility group box 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] |
CTD |
PMID:32464219 |
|
NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with endotoxin, Escherichia coli] results in increased expression of IL10 protein |
CTD |
PMID:32464219 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL1B protein] |
CTD |
PMID:22101131 PMID:23236370 PMID:32464219 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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G |
Il6 |
interleukin 6 |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein] |
CTD |
PMID:22101131 PMID:23236370 PMID:29476730 PMID:32464219 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
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|
G |
Irak4 |
interleukin-1 receptor-associated kinase 4 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IRAK4 protein] |
CTD |
PMID:32464219 |
|
NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
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G |
Mapk1 |
mitogen activated protein kinase 1 |
decreases phosphorylation multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK1 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] |
CTD |
PMID:22245252 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
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G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:22245252 |
|
NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mmp2 |
matrix metallopeptidase 2 |
decreases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 protein |
CTD |
PMID:22245252 |
|
NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
decreases expression multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein] |
CTD |
PMID:22245252 |
|
NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
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G |
Nfkbia |
NFKB inhibitor alpha |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] |
CTD |
PMID:22101131 |
|
NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] |
CTD |
PMID:22101131 PMID:23236370 PMID:26694894 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Parp1 |
poly (ADP-ribose) polymerase 1 |
increases degradation |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein |
CTD |
PMID:19135124 |
|
NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
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G |
Ppara |
peroxisome proliferator activated receptor alpha |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
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G |
Prkcd |
protein kinase C, delta |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] |
CTD |
PMID:22245252 |
|
NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] |
CTD |
PMID:22101131 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein] |
CTD |
PMID:22101131 PMID:26694894 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Rhoa |
ras homolog family member A |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein] |
CTD |
PMID:26694894 |
|
NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
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G |
Rock2 |
Rho-associated coiled-coil containing protein kinase 2 |
multiple interactions |
EXP |
[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein] |
CTD |
PMID:26694894 |
|
NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
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G |
Scd |
stearoyl-CoA desaturase |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]] |
CTD |
PMID:29476730 |
|
NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
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G |
Scd2 |
stearoyl-Coenzyme A desaturase 2 |
multiple interactions |
ISO |
[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Ethanol] results in decreased expression of SCD protein |
CTD |
PMID:29476730 |
|
NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
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G |
Slc22a6 |
solute carrier family 22 member 6 |
decreases activity multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A6 protein 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid] |
CTD |
PMID:32305507 |
|
NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
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G |
Slc22a8 |
solute carrier family 22 member 8 |
multiple interactions decreases activity |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A8 protein |
CTD |
PMID:32159797 PMID:32305507 |
|
NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
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G |
Slco1b2 |
solute carrier organic anion transporter family member 1B2 |
increases uptake |
ISO |
SLCO1B3 protein results in increased uptake of 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one |
CTD |
PMID:32305507 |
|
NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
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G |
Srebf1 |
sterol regulatory element binding transcription factor 1 |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] |
CTD |
PMID:29476730 |
|
NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
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G |
Stat1 |
signal transducer and activator of transcription 1 |
multiple interactions |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] |
CTD |
PMID:23236370 |
|
NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
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G |
Timp2 |
TIMP metallopeptidase inhibitor 2 |
increases expression |
ISO |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein |
CTD |
PMID:22245252 |
|
NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
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G |
Tjp1 |
tight junction protein 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of TJP1 protein] |
CTD |
PMID:32464219 |
|
NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]] 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein] |
CTD |
PMID:22101131 PMID:29476730 PMID:32464219 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Tp53 |
tumor protein p53 |
multiple interactions increases expression |
ISO |
diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TP53 protein modified form] |
CTD |
PMID:23470866 |
|
NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
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G |
Vcam1 |
vascular cell adhesion molecule 1 |
multiple interactions |
EXP |
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of VCAM1 protein] |
CTD |
PMID:32464219 |
|
NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
decreases activity |
ISO |
pedalitin results in decreased activity of CYP1A2 protein |
CTD |
PMID:29753067 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp2c6v1 |
cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 |
decreases activity |
ISO |
pedalitin results in decreased activity of CYP2C19 protein |
CTD |
PMID:29753067 |
|
NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
decreases activity |
ISO |
pedalitin results in decreased activity of CYP3A4 protein |
CTD |
PMID:29753067 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity multiple interactions |
ISO |
sciadopitysin results in decreased activity of ABCB1 protein sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] |
CTD |
PMID:30790579 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Bglap |
bone gamma-carboxyglutamate protein |
increases expression multiple interactions |
ISO |
sciadopitysin results in increased expression of BGLAP protein sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein] |
CTD |
PMID:23624148 |
|
NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
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G |
Tnf |
tumor necrosis factor |
multiple interactions |
ISO |
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] |
CTD |
PMID:23624148 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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G |
Casp3 |
caspase 3 |
affects binding |
ISO |
skullcapflavone II binds to CASP3 protein |
CTD |
PMID:32913905 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Mapk14 |
mitogen activated protein kinase 14 |
affects binding |
ISO |
skullcapflavone II binds to MAPK14 protein |
CTD |
PMID:32913905 |
|
NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
multiple interactions decreases activity |
ISO |
sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] sinensetin analog results in decreased activity of ABCB1 protein; sinensetin results in decreased activity of ABCB1 protein |
CTD |
PMID:30790579 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
increases metabolic processing |
ISO |
CYP1A1 protein results in increased metabolism of sinensetin |
CTD |
PMID:19666078 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases metabolic processing |
ISO |
CYP1A2 protein results in increased metabolism of sinensetin |
CTD |
PMID:19666078 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing |
ISO |
CYP1B1 protein results in increased metabolism of sinensetin |
CTD |
PMID:19666078 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases activity multiple interactions |
ISO |
sinensetin analog results in increased activity of CYP3A4 protein; sinensetin results in increased activity of CYP3A4 protein [[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam |
CTD |
PMID:31756459 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Slco1a1 |
solute carrier organic anion transporter family, member 1a1 |
multiple interactions decreases activity |
EXP |
[sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan |
CTD |
PMID:32259555 |
|
NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344
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G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
increases expression |
ISO |
tamarixetin results in increased expression of ABCB1 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Ahr |
aryl hydrocarbon receptor |
multiple interactions |
ISO |
tamarixetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] |
CTD |
PMID:17090139 |
|
NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
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G |
Akt1 |
AKT serine/threonine kinase 1 |
decreases phosphorylation |
ISO |
tamarixetin results in decreased phosphorylation of AKT1 protein |
CTD |
PMID:12826665 |
|
NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258
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G |
Casp3 |
caspase 3 |
increases activity |
ISO |
tamarixetin results in increased activity of CASP3 protein |
CTD |
PMID:12826665 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
increases expression |
ISO |
tamarixetin results in increased expression of CYP1A2 mRNA |
CTD |
PMID:19034627 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases expression |
ISO |
tamarixetin results in increased expression of CYP3A4 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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|
G |
Cyp3a9 |
cytochrome P450, family 3, subfamily a, polypeptide 9 |
increases expression |
ISO |
tamarixetin results in increased expression of CYP3A5 mRNA |
CTD |
PMID:26238175 |
|
NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399
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G |
Nr1i2 |
nuclear receptor subfamily 1, group I, member 2 |
multiple interactions increases activity |
ISO |
tamarixetin binds to and results in increased activity of NR1I2 protein tamarixetin results in increased activity of NR1I2 protein |
CTD |
PMID:26238175 |
|
NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545
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|
G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
decreases activity |
ISO |
tamarixetin results in decreased activity of PTGS2 protein |
CTD |
PMID:15292928 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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|
G |
Abcb1a |
ATP binding cassette subfamily B member 1A |
decreases activity multiple interactions |
ISO |
tangeretin results in decreased activity of ABCB1 protein tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin] |
CTD |
PMID:30790579 |
|
NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
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G |
Agtr1b |
angiotensin II receptor, type 1b |
multiple interactions |
EXP |
tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] |
CTD |
PMID:32479886 |
|
NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295
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|
G |
Casp3 |
caspase 3 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein] |
CTD |
PMID:27616468 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Cat |
catalase |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein] |
CTD |
PMID:24995432 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
|
|
G |
Cyb5a |
cytochrome b5 type A |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein] |
CTD |
PMID:24995432 |
|
NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821
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|
G |
Cybb |
cytochrome b-245 beta chain |
multiple interactions |
EXP |
tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] |
CTD |
PMID:32479886 |
|
NCBI chr X:14,578,330...14,610,049
Ensembl chr X:14,578,264...14,612,547
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|
G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions increases expression increases metabolic processing |
ISO |
tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein] tangeretin results in increased expression of CYP1A1 protein CYP1A1 protein results in increased metabolism of tangeretin |
CTD |
PMID:17090139 PMID:29626627 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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|
G |
Cyp1a2 |
cytochrome P450, family 1, subfamily a, polypeptide 2 |
multiple interactions increases metabolic processing |
ISO |
tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA] CYP1A2 protein results in increased metabolism of tangeretin |
CTD |
PMID:17090139 PMID:29626627 |
|
NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
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G |
Cyp1b1 |
cytochrome P450, family 1, subfamily b, polypeptide 1 |
increases metabolic processing increases expression |
ISO |
CYP1B1 protein results in increased metabolism of tangeretin tangeretin results in increased expression of CYP1B1 protein |
CTD |
PMID:29626627 |
|
NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
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|
G |
Cyp3a62 |
cytochrome P450, family 3, subfamily a, polypeptide 62 |
increases activity multiple interactions |
ISO |
tangeretin results in increased activity of CYP3A4 protein [[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam |
CTD |
PMID:31756459 |
|
NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397
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G |
Gsr |
glutathione-disulfide reductase |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein] |
CTD |
PMID:24995432 |
|
NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361
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|
G |
Hmox1 |
heme oxygenase 1 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HMOX1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HMOX1 protein] |
CTD |
PMID:24995432 |
|
NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456
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G |
Il10 |
interleukin 10 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [Cisplatin results in decreased expression of IL10 protein] |
CTD |
PMID:27616468 |
|
NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
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|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL1B protein] |
CTD |
PMID:24995432 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
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|
G |
Il6 |
interleukin 6 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 protein] |
CTD |
PMID:24995432 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Keap1 |
Kelch-like ECH-associated protein 1 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein] |
CTD |
PMID:24995432 |
|
NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779
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G |
Nfe2l2 |
nuclear factor, erythroid 2-like 2 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of NFE2L2 protein] |
CTD |
PMID:24995432 PMID:27616468 |
|
NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996
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G |
Nos2 |
nitric oxide synthase 2 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NOS2 protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] |
CTD |
PMID:24995432 PMID:27616468 |
|
NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
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G |
Nos3 |
nitric oxide synthase 3 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein] |
CTD |
PMID:32479886 |
|
NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410
|
|
G |
Nqo1 |
NAD(P)H quinone dehydrogenase 1 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NQO1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NQO1 protein] |
CTD |
PMID:24995432 |
|
NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180
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G |
Pkm |
pyruvate kinase M1/2 |
increases activity |
ISO |
tangeretin results in increased activity of PKM protein |
CTD |
PMID:25388478 |
|
NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722
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G |
Ptgs2 |
prostaglandin-endoperoxide synthase 2 |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 protein] |
CTD |
PMID:24995432 |
|
NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
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G |
Rela |
RELA proto-oncogene, NF-kB subunit |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RELA mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RELA protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of RELA protein] |
CTD |
PMID:24995432 PMID:27616468 |
|
NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
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G |
Star |
steroidogenic acute regulatory protein |
multiple interactions |
EXP |
tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] |
CTD |
PMID:32479886 |
|
NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847
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|
G |
Tnf |
tumor necrosis factor |
multiple interactions |
EXP |
tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of TNF protein] |
CTD |
PMID:24995432 PMID:27616468 |
|
NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
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|
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G |
Abcg2 |
ATP binding cassette subfamily G member 2 |
decreases activity |
ISO |
tectochrysin results in decreased activity of ABCG2 protein |
CTD |
PMID:15930306 |
|
NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
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G |
Alb |
albumin |
multiple interactions |
ISO |
wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein] |
CTD |
PMID:23246481 |
|
NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863
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|
G |
Bax |
BCL2 associated X, apoptosis regulator |
multiple interactions increases expression |
ISO |
[wogonin co-treated with Fluorouracil] results in increased expression of BAX protein wogonin results in increased expression of BAX protein |
CTD |
PMID:20570612 PMID:21457722 |
|
NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207
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|
G |
Bcl2 |
BCL2, apoptosis regulator |
multiple interactions decreases expression |
ISO |
[wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein wogonin results in decreased expression of BCL2 protein |
CTD |
PMID:20570612 |
|
NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
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G |
Casp3 |
caspase 3 |
increases activity multiple interactions |
ISO EXP |
wogonin results in increased activity of CASP3 protein wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein] wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein] [wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein |
CTD |
PMID:20570612 PMID:26756871 PMID:31103702 |
|
NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
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|
G |
Casp8 |
caspase 8 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] |
CTD |
PMID:26756871 |
|
NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
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G |
Cat |
catalase |
multiple interactions |
ISO EXP |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein] wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein] |
CTD |
PMID:26213241 PMID:31103702 |
|
NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058
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G |
Cav1 |
caveolin 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein] |
CTD |
PMID:23246481 |
|
NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200
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|
G |
Ccna2 |
cyclin A2 |
decreases expression |
ISO |
wogonin results in decreased expression of CCNA2 protein |
CTD |
PMID:21457722 |
|
NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214
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G |
Ccnd1 |
cyclin D1 |
decreases expression |
ISO EXP |
wogonin results in decreased expression of CCND1 protein |
CTD |
PMID:21457722 PMID:23872260 |
|
NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325
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G |
Cdk2 |
cyclin dependent kinase 2 |
decreases expression |
ISO EXP |
wogonin results in decreased expression of CDK2 protein |
CTD |
PMID:23872260 |
|
NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457
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G |
Cdk4 |
cyclin-dependent kinase 4 |
decreases expression |
ISO EXP |
wogonin results in decreased expression of CDK4 protein |
CTD |
PMID:23872260 |
|
NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418
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G |
Cdkn1a |
cyclin-dependent kinase inhibitor 1A |
increases expression |
ISO |
wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein |
CTD |
PMID:32671444 |
|
NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864
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G |
Cdkn1b |
cyclin-dependent kinase inhibitor 1B |
increases expression |
ISO EXP |
wogonin results in increased expression of CDKN1B protein |
CTD |
PMID:23872260 |
|
NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964
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G |
Cdkn2a |
cyclin-dependent kinase inhibitor 2A |
increases expression |
ISO |
wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein |
CTD |
PMID:32671444 |
|
NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175
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G |
Ctnnb1 |
catenin beta 1 |
decreases expression multiple interactions increases expression |
ISO EXP |
wogonin results in decreased expression of CTNNB1 protein Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein] wogonin results in increased expression of CTNNB1 protein modified form |
CTD |
PMID:23872260 PMID:31103702 |
|
NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372
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G |
Cyp1a1 |
cytochrome P450, family 1, subfamily a, polypeptide 1 |
multiple interactions decreases expression |
ISO |
wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA] wogonin results in decreased expression of CYP1A1 mRNA |
CTD |
PMID:18451504 |
|
NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
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G |
Dpyd |
dihydropyrimidine dehydrogenase |
decreases expression |
ISO |
wogonin results in decreased expression of DPYD mRNA |
CTD |
PMID:20570612 |
|
NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627
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G |
Gfap |
glial fibrillary acidic protein |
multiple interactions increases expression |
ISO EXP |
Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein] |
CTD |
PMID:23872260 |
|
NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506
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G |
Glb1 |
galactosidase, beta 1 |
increases expression |
ISO |
wogonin results in increased expression of GLB1 protein |
CTD |
PMID:32671444 |
|
NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939
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|
G |
Gsk3b |
glycogen synthase kinase 3 beta |
decreases expression increases expression |
ISO EXP |
wogonin results in decreased expression of GSK3B protein modified form wogonin results in increased expression of GSK3B protein |
CTD |
PMID:23872260 |
|
NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268
|
|
G |
Hif1a |
hypoxia inducible factor 1 subunit alpha |
multiple interactions |
ISO |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein] |
CTD |
PMID:26213241 |
|
NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
|
|
G |
Ifng |
interferon gamma |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] |
CTD |
PMID:23362215 |
|
NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419
|
|
G |
Il1b |
interleukin 1 beta |
multiple interactions |
ISO EXP |
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein] |
CTD |
PMID:26213241 PMID:31103702 |
|
NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
|
|
G |
Il6 |
interleukin 6 |
increases expression increases secretion |
ISO |
wogonin results in increased expression of IL6 protein wogonin results in increased secretion of IL6 protein wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein |
CTD |
PMID:32671444 |
|
NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
|
|
G |
Jun |
Jun proto-oncogene, AP-1 transcription factor subunit |
multiple interactions |
ISO |
wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] |
CTD |
PMID:17570322 |
|
NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277
|
|
G |
Map2k1 |
mitogen activated protein kinase kinase 1 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] |
CTD |
PMID:23362215 |
|
NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758
|
|
G |
Map2k2 |
mitogen activated protein kinase kinase 2 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] |
CTD |
PMID:23362215 |
|
NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489
|
|
G |
Mapk1 |
mitogen activated protein kinase 1 |
multiple interactions decreases phosphorylation |
ISO |
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein] wogonin results in decreased phosphorylation of MAPK1 protein |
CTD |
PMID:21295103 PMID:23362215 PMID:26892447 |
|
NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
|
|
G |
Mapk3 |
mitogen activated protein kinase 3 |
multiple interactions decreases phosphorylation |
ISO |
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein] wogonin results in decreased phosphorylation of MAPK3 protein |
CTD |
PMID:21295103 PMID:23362215 PMID:26892447 |
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NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
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G |
Mapk8 |
mitogen-activated protein kinase 8 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] |
CTD |
PMID:23362215 |
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NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347
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G |
Mapk9 |
mitogen-activated protein kinase 9 |
multiple interactions |
ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein] |
CTD |
PMID:23362215 |
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NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355
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G |
Mki67 |
marker of proliferation Ki-67 |
decreases expression |
ISO |
wogonin results in decreased expression of MKI67 protein |
CTD |
PMID:32671444 |
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NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454
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G |
Mmp2 |
matrix metallopeptidase 2 |
multiple interactions |
ISO |
wogonin results in decreased expression of and results in decreased activity of MMP2 protein |
CTD |
PMID:21295103 |
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NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
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G |
Mmp9 |
matrix metallopeptidase 9 |
multiple interactions |
EXP ISO |
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein] wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein |
CTD |
PMID:14700523 PMID:21295103 |
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