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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:methoxyflavone
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Accession:CHEBI:25241 term browser browse the term
Definition:Any member of the class of flavones with at least one methoxy substituent.
Synonyms:related_synonym: methoxyflavones

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3',4',5-trihydroxy-3,7-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccnb1 cyclin B1 affects phosphorylation
increases expression		 ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CCNB1 protein
5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CCNB1 protein		 CTD PMID:21229608 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cdc25c cell division cycle 25C affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDC25C protein CTD PMID:21229608 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdk1 cyclin-dependent kinase 1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of CDK1 protein CTD PMID:21229608 NCBI chr20:20,576,341...20,591,510
Ensembl chr20:20,576,377...20,591,549 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased expression of CDKN1A protein CTD PMID:21229608 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Foxm1 forkhead box M1 affects phosphorylation ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone affects the phosphorylation of FOXM1 protein CTD PMID:21229608 NCBI chr 4:161,685,236...161,697,633
Ensembl chr 4:161,685,258...161,696,305 		JBrowse link
G Smpd1 sphingomyelin phosphodiesterase 1 increases activity ISO 5,7,3'-trihydroxy-3,4'-dimethoxyflavone results in increased activity of SMPD1 protein CTD PMID:21229608 NCBI chr 1:170,383,682...170,387,525
Ensembl chr 1:170,383,682...170,387,524 		JBrowse link
3',5'-di-O-methyltricetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO tricin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein] CTD PMID:16552572 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
3',5'-dimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3',5'-dimethoxyflavone inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:12644593 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809 		JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894 		JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538 		JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704 		JBrowse link
5,6,7-trimethoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Fos Fos proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of FOS protein] CTD PMID:24161485 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] CTD PMID:24161485 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL6 protein] CTD PMID:24161485 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of JUN protein] CTD PMID:24161485 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:24161485 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]] which results in decreased abundance of Nitric Oxide CTD PMID:24161485 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]; [5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]] which results in decreased abundance of Dinoprostone CTD PMID:24161485 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of RELA protein] CTD PMID:24161485 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT1 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT1 protein] CTD PMID:24161485 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 affects the localization of STAT3 protein]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of STAT3 protein] CTD PMID:24161485 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF mRNA]; 5,6,7-trimethoxyflavone inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein] CTD PMID:24161485 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
5,7-dihydroxy-4'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1A1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1A1 mRNA
acacetin results in decreased activity of CYP1A1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO acacetin results in decreased activity of CYP1A2 protein CTD PMID:21053930 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of acacetin
acacetin results in increased expression of CYP1B1 mRNA
acacetin results in decreased activity of CYP1B1 protein
acacetin binds to and results in decreased activity of CYP1B1 protein		 CTD PMID:10781868 PMID:21053930 PMID:21482471 PMID:31621310 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression
multiple interactions		 ISO acacetin results in increased expression of CYP3A4 mRNA
acacetin binds to and results in decreased activity of CYP3A4 protein; acacetin inhibits the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 4-hydroxymidazolam]; acacetin promotes the reaction [[CYP3A4 protein results in increased oxidation of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam]		 CTD PMID:21053930 PMID:29933105 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 increases activity
increases expression
multiple interactions		 ISO acacetin results in increased activity of NR1I2 protein
acacetin results in increased expression of NR1I2 mRNA
acacetin results in increased activity of and results in increased expression of NR1I2 protein; sulforafan inhibits the reaction [acacetin results in increased activity of NR1I2 protein]		 CTD PMID:25455453 PMID:29933105 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Ugt1a1 UDP glucuronosyltransferase family 1 member A1 increases expression ISO acacetin results in increased expression of UGT1A1 mRNA CTD PMID:31621310 NCBI chr 9:95,295,701...95,302,822
Ensembl chr 9:95,161,157...95,302,822 		JBrowse link
casticin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc5 ATP binding cassette subfamily C member 5 increases expression ISO casticin results in increased expression of ABCC5 mRNA CTD PMID:28444820 NCBI chr11:84,395,982...84,490,215
Ensembl chr11:84,396,033...84,490,211 		JBrowse link
G Adam10 ADAM metallopeptidase domain 10 increases expression ISO casticin results in increased expression of ADAM10 mRNA CTD PMID:28444820 NCBI chr 8:77,107,355...77,237,483
Ensembl chr 8:77,107,536...77,237,483 		JBrowse link
G Aftph aftiphilin decreases expression ISO casticin results in decreased expression of AFTPH mRNA CTD PMID:28444820 NCBI chr14:104,921,633...104,975,763
Ensembl chr14:104,922,282...104,960,141 		JBrowse link
G Agap1 ArfGAP with GTPase domain, ankyrin repeat and PH domain 1 decreases expression ISO casticin results in decreased expression of AGAP1 mRNA CTD PMID:28444820 NCBI chr 9:96,718,901...97,034,400
Ensembl chr 9:96,621,586...97,030,163 		JBrowse link
G Aifm1 apoptosis inducing factor, mitochondria associated 1 increases expression ISO casticin results in increased expression of AIFM1 protein CTD PMID:29098808 NCBI chr  X:135,304,063...135,343,062
Ensembl chr  X:135,304,066...135,343,087 		JBrowse link
G Akirin2 akirin 2 decreases expression ISO casticin results in decreased expression of AKIRIN2 mRNA CTD PMID:28444820 NCBI chr 5:50,001,945...50,016,544
Ensembl chr 5:50,002,184...50,016,539 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases expression ISO casticin results in decreased expression of AKT1 protein CTD PMID:28444820 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Akt3 AKT serine/threonine kinase 3 decreases expression ISO casticin results in decreased expression of AKT3 mRNA CTD PMID:27862857 NCBI chr13:95,076,308...95,348,913
Ensembl chr13:95,081,390...95,348,913 		JBrowse link
G Aldh1a1 aldehyde dehydrogenase 1 family, member A1 increases expression ISO casticin results in increased expression of ALDH1A1 mRNA CTD PMID:27862857 NCBI chr 1:238,222,689...238,264,381
Ensembl chr 1:238,222,521...238,264,330 		JBrowse link
G Alx1 ALX homeobox 1 decreases expression ISO casticin results in decreased expression of ALX1 mRNA CTD PMID:28444820 NCBI chr 7:44,751,865...44,771,458
Ensembl chr 7:44,751,873...44,771,458 		JBrowse link
G Apaf1 apoptotic peptidase activating factor 1 increases expression ISO casticin results in increased expression of APAF1 protein CTD PMID:27862857 NCBI chr 7:31,699,309...31,784,192
Ensembl chr 7:31,699,885...31,784,192 		JBrowse link
G Arl6ip4 ADP-ribosylation factor like GTPase 6 interacting protein 4 decreases expression ISO casticin results in decreased expression of ARL6IP4 mRNA CTD PMID:28444820 NCBI chr12:37,904,376...37,906,521
Ensembl chr12:37,904,379...37,906,521 		JBrowse link
G Armc9 armadillo repeat containing 9 decreases expression ISO casticin results in decreased expression of ARMC9 mRNA CTD PMID:28444820 NCBI chr 9:93,172,718...93,299,119
Ensembl chr 9:93,172,673...93,296,750 		JBrowse link
G Arntl aryl hydrocarbon receptor nuclear translocator-like decreases expression ISO casticin results in decreased expression of ARNTL mRNA CTD PMID:28444820 NCBI chr 1:178,039,002...178,137,469
Ensembl chr 1:178,039,063...178,137,465 		JBrowse link
G Arpc5l actin related protein 2/3 complex, subunit 5-like decreases expression ISO casticin results in decreased expression of ARPC5L mRNA CTD PMID:28444820 NCBI chr 3:23,301,455...23,309,077
Ensembl chr 3:23,301,455...23,309,072 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) decreases expression ISO casticin results in decreased expression of ASNS mRNA CTD PMID:28444820 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Atf5 activating transcription factor 5 decreases expression ISO casticin results in decreased expression of ATF5 mRNA CTD PMID:28444820 NCBI chr 1:100,807,821...100,812,410
Ensembl chr 1:100,808,241...100,810,522 		JBrowse link
G Atf6 activating transcription factor 6 increases expression ISO casticin results in increased expression of ATF6 protein CTD PMID:27862857 NCBI chr13:89,053,457...89,242,531
Ensembl chr13:89,055,983...89,242,443 		JBrowse link
G Atm ATM serine/threonine kinase decreases expression ISO casticin results in decreased expression of ATM protein CTD PMID:29098808 NCBI chr 8:58,015,938...58,119,973
Ensembl chr 8:58,015,940...58,120,045 		JBrowse link
G Atox1 antioxidant 1 copper chaperone increases expression ISO casticin results in increased expression of ATOX1 mRNA CTD PMID:28444820 NCBI chr10:40,790,850...40,805,886
Ensembl chr10:40,790,845...40,805,941 		JBrowse link
G Atp6v1g1 ATPase H+ transporting V1 subunit G1 decreases expression ISO casticin results in decreased expression of ATP6V1G1 mRNA CTD PMID:28444820 NCBI chr 5:79,367,663...79,373,843
Ensembl chr 5:79,367,663...79,373,843 		JBrowse link
G Atp8a1 ATPase phospholipid transporting 8A1 increases expression ISO casticin results in increased expression of ATP8A1 mRNA CTD PMID:28444820 NCBI chr14:41,972,398...42,210,555
Ensembl chr14:42,015,347...42,206,311 		JBrowse link
G Atr ATR serine/threonine kinase decreases expression ISO casticin results in decreased expression of ATR protein CTD PMID:29098808 NCBI chr 8:103,673,578...103,770,886
Ensembl chr 8:103,673,411...103,770,947 		JBrowse link
G Atxn7l3b ataxin 7-like 3B decreases expression ISO casticin results in decreased expression of ATXN7L3B mRNA CTD PMID:28444820 NCBI chr 7:55,600,879...55,604,403
Ensembl chr 7:55,600,889...55,604,403 		JBrowse link
G Avpr1a arginine vasopressin receptor 1A decreases expression ISO casticin results in decreased expression of AVPR1A mRNA CTD PMID:28444820 NCBI chr 7:67,341,366...67,345,290
Ensembl chr 7:67,341,080...67,345,308 		JBrowse link
G Axin2 axin 2 increases expression ISO casticin results in increased expression of AXIN2 mRNA CTD PMID:27862857 NCBI chr10:97,212,483...97,238,824
Ensembl chr10:97,212,432...97,239,642 		JBrowse link
G Bak1 BCL2-antagonist/killer 1 increases expression ISO casticin results in increased expression of BAK1 protein CTD PMID:27862857 NCBI chr20:5,609,620...5,618,899
Ensembl chr20:5,609,625...5,618,260 		JBrowse link
G Bambi BMP and activin membrane-bound inhibitor increases expression ISO casticin results in increased expression of BAMBI mRNA CTD PMID:27862857 NCBI chr17:56,905,419...56,909,675
Ensembl chr17:56,905,112...56,909,992 		JBrowse link
G Basp1 brain abundant, membrane attached signal protein 1 decreases expression ISO casticin results in decreased expression of BASP1 mRNA CTD PMID:28444820 NCBI chr 2:77,586,424...77,632,626
Ensembl chr 2:77,586,424...77,632,628 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator increases expression ISO casticin results in increased expression of BAX protein CTD PMID:27862857 PMID:29098808 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl11a BAF chromatin remodeling complex subunit BCL11A decreases expression ISO casticin results in decreased expression of BCL11A mRNA CTD PMID:28444820 NCBI chr14:108,826,717...108,921,197
Ensembl chr14:108,826,831...108,921,669 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO casticin results in decreased expression of BCL2 protein CTD PMID:27862857 PMID:29098808 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression
increases expression		 ISO casticin results in decreased expression of BCL2L1 protein
casticin results in increased expression of BCL2L1 mRNA		 CTD PMID:27862857 PMID:29098808 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Bid BH3 interacting domain death agonist increases expression
decreases expression		 ISO casticin results in increased expression of BID protein
casticin results in decreased expression of BID protein		 CTD PMID:27862857 PMID:29098808 NCBI chr 4:153,439,812...153,465,247
Ensembl chr 4:153,442,218...153,465,203 		JBrowse link
G Bmi1 BMI1 proto-oncogene, polycomb ring finger multiple interactions
decreases expression		 ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA] CTD PMID:32268151 NCBI chr17:85,360,439...85,370,283
Ensembl chr17:85,364,483...85,368,208 		JBrowse link
G Bmp4 bone morphogenetic protein 4 increases expression ISO casticin results in increased expression of BMP4 mRNA CTD PMID:27862857 NCBI chr15:20,776,060...20,791,013
Ensembl chr15:20,776,054...20,822,740 		JBrowse link
G Bnip2 BCL2 interacting protein 2 decreases expression ISO casticin results in decreased expression of BNIP2 mRNA CTD PMID:27862857 NCBI chr 8:76,400,333...76,426,307
Ensembl chr 8:76,400,341...76,426,503 		JBrowse link
G Brca1 BRCA1, DNA repair associated increases expression ISO casticin results in increased expression of BRCA1 protein CTD PMID:29098808 NCBI chr10:89,394,821...89,455,093
Ensembl chr10:89,394,803...89,454,681 		JBrowse link
G Btf3 basic transcription factor 3 decreases expression ISO casticin results in decreased expression of BTF3 mRNA CTD PMID:28444820 NCBI chr 2:28,417,316...28,424,436
Ensembl chr 2:28,417,579...28,423,762 		JBrowse link
G Btg1 BTG anti-proliferation factor 1 decreases expression ISO casticin results in decreased expression of BTG1 mRNA CTD PMID:28444820 NCBI chr 7:37,812,831...37,815,088
Ensembl chr 7:37,812,831...37,815,088 		JBrowse link
G Cadm1 cell adhesion molecule 1 increases expression ISO casticin results in increased expression of CADM1 mRNA CTD PMID:28444820 NCBI chr 8:51,858,906...52,200,591
Ensembl chr 8:52,127,399...52,189,722 		JBrowse link
G Calcoco1 calcium binding and coiled coil domain 1 decreases expression ISO casticin results in decreased expression of CALCOCO1 mRNA CTD PMID:28444820 NCBI chr 7:144,307,562...144,322,253
Ensembl chr 7:144,307,509...144,322,240 		JBrowse link
G Calm1 calmodulin 1 decreases expression ISO casticin results in decreased expression of CALM1 mRNA CTD PMID:28444820 NCBI chr 6:124,217,241...124,225,292
Ensembl chr 6:124,217,241...124,225,292 		JBrowse link
G Camk4 calcium/calmodulin-dependent protein kinase IV decreases expression ISO casticin results in decreased expression of CAMK4 mRNA CTD PMID:27862857 NCBI chr18:25,746,878...25,975,962
Ensembl chr18:25,749,098...25,965,957 		JBrowse link
G Capn1 calpain 1 multiple interactions ISO casticin results in increased expression of and results in increased cleavage of CAPN1 protein CTD PMID:27862857 NCBI chr 1:221,346,081...221,370,965
Ensembl chr 1:221,346,066...221,370,322 		JBrowse link
G Capn2 calpain 2 increases expression ISO casticin results in increased expression of CAPN2 protein CTD PMID:27862857 NCBI chr13:100,878,649...100,928,811
Ensembl chr13:100,878,650...100,928,811 		JBrowse link
G Casp2 caspase 2 increases expression ISO casticin results in increased expression of CASP2 protein CTD PMID:27862857 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 multiple interactions
increases activity		 ISO casticin results in increased cleavage of and results in increased activity of CASP3 protein
casticin results in increased activity of CASP3 protein		 CTD PMID:27862857 PMID:29098808 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp4 caspase 4 increases expression ISO casticin results in increased expression of CASP4 protein CTD PMID:27862857 NCBI chr 8:2,616,391...2,651,682
Ensembl chr 8:2,635,851...2,651,652 		JBrowse link
G Casp6 caspase 6 increases expression ISO casticin results in increased expression of CASP6 protein CTD PMID:27862857 NCBI chr 2:235,341,326...235,353,715
Ensembl chr 2:235,341,365...235,353,967
Ensembl chr 2:235,341,365...235,353,967 		JBrowse link
G Casp7 caspase 7 increases expression ISO casticin results in increased expression of CASP7 protein CTD PMID:27862857 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO casticin results in increased cleavage of and results in increased activity of CASP8 protein; casticin results in increased expression of and results in increased activity of CASP8 protein CTD PMID:27862857 PMID:29098808 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions
increases activity		 ISO casticin results in increased cleavage of and results in increased activity of CASP9 protein
casticin results in increased activity of CASP9 protein		 CTD PMID:27862857 PMID:29098808 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccdc122 coiled-coil domain containing 122 increases expression ISO casticin results in increased expression of CCDC122 mRNA CTD PMID:28444820 NCBI chr15:59,159,822...59,280,538
Ensembl chr15:59,216,705...59,279,967 		JBrowse link
G Ccdc174 coiled-coil domain containing 174 decreases expression ISO casticin results in decreased expression of CCDC174 mRNA CTD PMID:28444820 NCBI chr 4:123,760,708...123,787,529
Ensembl chr 4:123,760,743...123,787,528 		JBrowse link
G Ccdc90b coiled-coil domain containing 90B decreases expression ISO casticin results in decreased expression of CCDC90B mRNA CTD PMID:28444820 NCBI chr 1:157,403,595...157,417,153
Ensembl chr 1:157,403,595...157,417,147 		JBrowse link
G Ccn1 cellular communication network factor 1 increases expression ISO casticin results in increased expression of CCN1 mRNA CTD PMID:28444820 NCBI chr 2:251,529,354...251,532,312
Ensembl chr 2:251,529,354...251,532,312 		JBrowse link
G Ccnb1 cyclin B1 decreases expression ISO casticin results in decreased expression of CCNB1 protein CTD PMID:29098808 NCBI chr 2:30,782,133...30,791,106
Ensembl chr 2:30,783,915...30,791,221 		JBrowse link
G Cct4 chaperonin containing TCP1 subunit 4 decreases expression ISO casticin results in decreased expression of CCT4 mRNA CTD PMID:28444820 NCBI chr14:107,767,392...107,780,270
Ensembl chr14:107,767,392...107,780,270 		JBrowse link
G Cd24 CD24 molecule increases expression ISO casticin results in increased expression of CD24 mRNA CTD PMID:27862857 NCBI chr20:48,335,540...48,340,847
Ensembl chr20:48,335,540...48,340,846 		JBrowse link
G Cd44 CD44 molecule (Indian blood group) decreases expression
multiple interactions		 ISO casticin results in decreased expression of CD44 mRNA; casticin results in decreased expression of CD44 protein
casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]		 CTD PMID:32268151 NCBI chr 3:92,695,083...92,783,820
Ensembl chr 3:92,696,313...92,783,658 		JBrowse link
G Cd83 CD83 molecule decreases expression ISO casticin results in decreased expression of CD83 mRNA CTD PMID:27862857 NCBI chr17:24,416,651...24,435,790
Ensembl chr17:24,416,651...24,435,790 		JBrowse link
G Cdc25c cell division cycle 25C decreases expression ISO casticin results in decreased expression of CDC25C protein CTD PMID:29098808 NCBI chr18:27,528,768...27,550,316
Ensembl chr18:27,528,354...27,550,224 		JBrowse link
G Cdc42 cell division cycle 42 decreases expression ISO casticin results in decreased expression of CDC42 mRNA CTD PMID:28444820 NCBI chr 5:155,690,267...155,728,385
Ensembl chr 5:155,691,390...155,728,300 		JBrowse link
G Cdh17 cadherin 17 increases expression ISO casticin results in increased expression of CDH17 mRNA CTD PMID:27862857 NCBI chr 5:25,354,187...25,443,675
Ensembl chr 5:25,391,115...25,443,718 		JBrowse link
G Cdk2 cyclin dependent kinase 2 increases expression ISO casticin results in increased expression of CDK2 protein CTD PMID:29098808 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A decreases expression ISO casticin results in decreased expression of CDKN1A mRNA; casticin results in decreased expression of CDKN1A protein CTD PMID:27862857 PMID:29098808 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO casticin results in increased expression of CDKN1B mRNA CTD PMID:27862857 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO casticin results in increased expression of CDKN2A protein CTD PMID:29098808 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression ISO casticin results in increased expression of CHEK2 protein CTD PMID:29098808 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Chic2 cysteine-rich hydrophobic domain 2 decreases expression ISO casticin results in decreased expression of CHIC2 mRNA CTD PMID:28444820 NCBI chr14:35,683,657...35,718,005
Ensembl chr14:35,683,442...35,717,922 		JBrowse link
G Cldn1 claudin 1 decreases expression ISO casticin results in decreased expression of CLDN1 mRNA CTD PMID:27862857 NCBI chr11:77,815,216...77,830,373
Ensembl chr11:77,815,181...77,830,416 		JBrowse link
G Cnbp CCHC-type zinc finger, nucleic acid binding protein decreases expression ISO casticin results in decreased expression of CNBP mRNA CTD PMID:28444820 NCBI chr 4:119,747,890...119,756,787
Ensembl chr 4:119,747,911...119,756,765 		JBrowse link
G Col1a1 collagen type I alpha 1 chain decreases expression ISO casticin results in decreased expression of COL1A1 mRNA CTD PMID:27862857 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cpe carboxypeptidase E increases expression ISO casticin results in increased expression of CPE mRNA CTD PMID:28444820 NCBI chr16:26,906,716...27,014,811
Ensembl chr16:26,906,716...27,014,813 		JBrowse link
G Creb1 cAMP responsive element binding protein 1 increases expression ISO casticin results in increased expression of CREB1 mRNA CTD PMID:27862857 NCBI chr 9:71,229,753...71,298,994
Ensembl chr 9:71,230,108...71,293,435 		JBrowse link
G Crhbp corticotropin releasing hormone binding protein decreases expression ISO casticin results in decreased expression of CRHBP mRNA CTD PMID:28444820 NCBI chr 2:25,141,471...25,153,334
Ensembl chr 2:25,141,471...25,153,334 		JBrowse link
G Crls1 cardiolipin synthase 1 decreases expression ISO casticin results in decreased expression of CRLS1 mRNA CTD PMID:28444820 NCBI chr 3:125,503,638...125,522,460
Ensembl chr 3:125,503,638...125,522,441 		JBrowse link
G Cryab crystallin, alpha B increases expression ISO casticin results in increased expression of CRYAB mRNA CTD PMID:28444820 NCBI chr 8:55,178,543...55,182,546
Ensembl chr 8:55,178,289...55,182,545 		JBrowse link
G Csnk1a1 casein kinase 1, alpha 1 decreases expression ISO casticin results in decreased expression of CSNK1A1 mRNA CTD PMID:28444820 NCBI chr18:56,887,722...56,910,610
Ensembl chr18:56,887,354...56,918,345 		JBrowse link
G Cyb5r1 cytochrome b5 reductase 1 decreases expression ISO casticin results in decreased expression of CYB5R1 mRNA CTD PMID:28444820 NCBI chr13:51,229,697...51,236,447
Ensembl chr13:51,229,890...51,236,463 		JBrowse link
G Cycs cytochrome c, somatic increases expression ISO casticin results in increased expression of CYCS protein CTD PMID:27862857 PMID:29098808 NCBI chr 4:80,331,226...80,333,326
Ensembl chr 4:80,331,227...80,333,326 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 decreases expression ISO casticin results in decreased expression of DDIT3 mRNA CTD PMID:28444820 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Ddx27 DEAD-box helicase 27 decreases expression ISO casticin results in decreased expression of DDX27 mRNA CTD PMID:28444820 NCBI chr 3:163,767,236...163,786,408
Ensembl chr 3:163,767,173...163,786,445 		JBrowse link
G Dip2c disco-interacting protein 2 homolog C decreases expression ISO casticin results in decreased expression of DIP2C mRNA CTD PMID:28444820 NCBI chr17:63,426,688...63,810,183
Ensembl chr17:63,635,086...63,808,464 		JBrowse link
G Dkk3 dickkopf WNT signaling pathway inhibitor 3 decreases expression ISO casticin results in decreased expression of DKK3 mRNA CTD PMID:27862857 NCBI chr 1:176,940,424...176,983,076
Ensembl chr 1:176,940,693...176,983,045 		JBrowse link
G Dnmt1 DNA methyltransferase 1 multiple interactions
decreases activity
decreases expression		 ISO casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin results in decreased expression of and results in decreased activity of DNMT1 protein; DNMT1 protein inhibits the reaction [casticin results in decreased activity of DNMT1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of BMI1 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of CD44 protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein] CTD PMID:32268151 NCBI chr 8:21,922,515...21,968,495
Ensembl chr 8:21,922,515...21,968,495 		JBrowse link
G Dusp6 dual specificity phosphatase 6 decreases expression ISO casticin results in decreased expression of DUSP6 mRNA CTD PMID:28444820 NCBI chr 7:41,475,163...41,479,393
Ensembl chr 7:41,475,163...41,479,392 		JBrowse link
G Dyrk1a dual specificity tyrosine phosphorylation regulated kinase 1A decreases expression ISO casticin results in decreased expression of DYRK1A mRNA CTD PMID:28444820 NCBI chr11:34,858,339...34,958,733
Ensembl chr11:34,865,532...34,956,536 		JBrowse link
G Egfr epidermal growth factor receptor decreases expression ISO casticin results in decreased expression of EGFR protein CTD PMID:28444820 NCBI chr14:99,919,485...100,104,136
Ensembl chr14:99,919,485...100,098,796 		JBrowse link
G Eif2s2 eukaryotic translation initiation factor 2 subunit beta decreases expression ISO casticin results in decreased expression of EIF2S2 mRNA CTD PMID:28444820 NCBI chr 3:150,391,455...150,412,179
Ensembl chr 3:150,391,460...150,412,179 		JBrowse link
G Eif5 eukaryotic translation initiation factor 5 decreases expression ISO casticin results in decreased expression of EIF5 mRNA CTD PMID:28444820 NCBI chr 6:136,002,983...136,011,409
Ensembl chr 6:136,004,214...136,011,406 		JBrowse link
G Enc1 ectodermal-neural cortex 1 increases expression ISO casticin results in increased expression of ENC1 mRNA CTD PMID:27862857 NCBI chr 2:28,049,217...28,061,023
Ensembl chr 2:28,049,217...28,061,029 		JBrowse link
G Endog endonuclease G decreases expression ISO casticin results in decreased expression of ENDOG protein CTD PMID:29098808 NCBI chr 3:8,741,833...8,744,414
Ensembl chr 3:8,741,766...8,744,592 		JBrowse link
G Ep300 E1A binding protein p300 decreases expression ISO casticin results in decreased expression of EP300 mRNA CTD PMID:27862857 NCBI chr 7:122,818,194...122,889,055
Ensembl chr 7:122,818,975...122,861,296 		JBrowse link
G Epb41l4b erythrocyte membrane protein band 4.1 like 4B decreases expression ISO casticin results in decreased expression of EPB41L4B mRNA CTD PMID:28444820 NCBI chr 5:74,030,950...74,192,275
Ensembl chr 5:74,030,882...74,191,167 		JBrowse link
G Epcam epithelial cell adhesion molecule multiple interactions
decreases expression		 ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of EPCAM protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA] CTD PMID:32268151 NCBI chr 6:11,282,194...11,308,870
Ensembl chr 6:11,281,964...11,298,216 		JBrowse link
G Erbb3 erb-b2 receptor tyrosine kinase 3 increases expression ISO casticin results in increased expression of ERBB3 mRNA CTD PMID:27862857 NCBI chr 7:2,989,202...3,010,610
Ensembl chr 7:2,989,340...3,010,350 		JBrowse link
G Esf1 ESF1 nucleolar pre-rRNA processing protein homolog decreases expression ISO casticin results in decreased expression of ESF1 mRNA CTD PMID:28444820 NCBI chr 3:133,178,591...133,232,358
Ensembl chr 3:133,178,561...133,232,322 		JBrowse link
G Exosc3 exosome component 3 decreases expression ISO casticin results in decreased expression of EXOSC3 mRNA CTD PMID:28444820 NCBI chr 5:60,866,498...60,871,734
Ensembl chr 5:60,868,502...60,871,705 		JBrowse link
G Ext1 exostosin glycosyltransferase 1 increases expression ISO casticin results in increased expression of EXT1 mRNA CTD PMID:28444820 NCBI chr 7:92,605,008...92,881,392
Ensembl chr 7:92,605,728...92,882,068 		JBrowse link
G Fadd Fas associated via death domain increases expression ISO casticin results in increased expression of FADD protein CTD PMID:27862857 PMID:29098808 NCBI chr 1:217,746,176...217,748,581
Ensembl chr 1:217,742,929...217,748,628 		JBrowse link
G Fam227a family with sequence similarity 227, member A increases expression ISO casticin results in increased expression of FAM227A mRNA CTD PMID:28444820 NCBI chr 7:120,846,166...120,891,738
Ensembl chr 7:120,846,330...120,882,392 		JBrowse link
G Fas Fas cell surface death receptor increases expression ISO casticin results in increased expression of FAS protein CTD PMID:27862857 PMID:29098808 NCBI chr 1:252,589,785...252,624,790
Ensembl chr 1:252,589,785...252,624,790 		JBrowse link
G Faslg Fas ligand increases expression
decreases expression		 ISO casticin results in increased expression of FASLG protein
casticin results in decreased expression of FASLG protein		 CTD PMID:27862857 PMID:29098808 NCBI chr13:79,696,811...79,717,581
Ensembl chr13:79,698,445...79,705,705 		JBrowse link
G Fbxo11 F-box protein 11 decreases expression ISO casticin results in decreased expression of FBXO11 mRNA CTD PMID:28444820 NCBI chr 6:11,662,356...11,737,427
Ensembl chr 6:11,662,356...11,686,682 		JBrowse link
G Fbxo44 F-box protein 44 decreases expression ISO casticin results in decreased expression of FBXO44 mRNA CTD PMID:28444820 NCBI chr 5:164,962,921...164,972,273
Ensembl chr 5:164,963,433...164,971,903 		JBrowse link
G Fez1 fasciculation and elongation protein zeta 1 decreases expression ISO casticin results in decreased expression of FEZ1 mRNA CTD PMID:28444820 NCBI chr 8:39,305,128...39,350,270
Ensembl chr 8:39,305,128...39,350,270 		JBrowse link
G Foxo3 forkhead box O3 decreases expression ISO casticin results in decreased expression of FOXO3 mRNA CTD PMID:27862857 NCBI chr20:46,428,078...46,519,156
Ensembl chr20:46,428,124...46,519,144 		JBrowse link
G Foxp2 forkhead box P2 decreases expression ISO casticin results in decreased expression of FOXP2 mRNA CTD PMID:28444820 NCBI chr 4:41,364,441...41,944,685
Ensembl chr 4:41,364,441...41,942,023 		JBrowse link
G Gadd45a growth arrest and DNA-damage-inducible, alpha decreases expression ISO casticin results in decreased expression of GADD45A mRNA CTD PMID:28444820 NCBI chr 4:97,782,512...97,784,814
Ensembl chr 4:97,782,512...97,784,842 		JBrowse link
G Glud1 glutamate dehydrogenase 1 decreases expression ISO casticin results in decreased expression of GLUD1 mRNA CTD PMID:28444820 NCBI chr16:10,661,486...10,695,557
Ensembl chr16:10,662,021...10,695,557 		JBrowse link
G Gphn gephyrin decreases expression ISO casticin results in decreased expression of GPHN mRNA CTD PMID:28444820 NCBI chr 6:101,327,874...101,859,169
Ensembl chr 6:101,532,518...101,859,164 		JBrowse link
G Gpr85 G protein-coupled receptor 85 decreases expression ISO casticin results in decreased expression of GPR85 mRNA CTD PMID:28444820 NCBI chr 4:40,377,705...40,387,147
Ensembl chr 4:40,381,685...40,385,349 		JBrowse link
G Grb2 growth factor receptor bound protein 2 decreases expression ISO casticin results in decreased expression of GRB2 protein CTD PMID:28444820 NCBI chr10:104,193,953...104,263,071
Ensembl chr10:104,193,955...104,263,071 		JBrowse link
G Grid2 glutamate ionotropic receptor delta type subunit 2 decreases expression ISO casticin results in decreased expression of GRID2 mRNA CTD PMID:27862857 NCBI chr 4:94,068,112...95,476,864
Ensembl chr 4:94,696,965...95,442,778 		JBrowse link
G Hcn2 hyperpolarization activated cyclic nucleotide gated potassium and sodium channel 2 decreases expression ISO casticin results in decreased expression of HCN2 mRNA CTD PMID:27862857 NCBI chr 7:12,851,730...12,870,087
Ensembl chr 7:12,851,739...12,874,215 		JBrowse link
G Hoxb8 homeo box B8 decreases expression ISO casticin results in decreased expression of HOXB8 mRNA CTD PMID:28444820 NCBI chr10:84,131,484...84,133,874
Ensembl chr10:84,131,495...84,133,246 		JBrowse link
G Hoxb9 homeo box B9 decreases expression ISO casticin results in decreased expression of HOXB9 mRNA CTD PMID:27862857 NCBI chr10:84,119,772...84,124,963
Ensembl chr10:84,119,884...84,123,390 		JBrowse link
G Hspa4 heat shock protein family A (Hsp70) member 4 decreases expression ISO casticin results in decreased expression of HSPA4 mRNA CTD PMID:28444820 NCBI chr10:38,601,624...38,642,397
Ensembl chr10:38,601,624...38,642,397 		JBrowse link
G Hspa5 heat shock protein family A (Hsp70) member 5 increases expression ISO casticin results in increased expression of HSPA5 protein CTD PMID:27862857 NCBI chr 3:13,838,304...13,842,763
Ensembl chr 3:13,838,304...13,842,762 		JBrowse link
G Hspa8 heat shock protein family A (Hsp70) member 8 increases expression ISO casticin results in increased expression of HSPA8 mRNA CTD PMID:28444820 NCBI chr 8:44,989,401...44,993,261
Ensembl chr 8:44,990,014...44,993,179 		JBrowse link
G Hspa9 heat shock protein family A (Hsp70) member 9 decreases expression ISO casticin results in decreased expression of HSPA9 mRNA CTD PMID:28444820 NCBI chr18:27,731,072...27,749,235
Ensembl chr18:27,731,072...27,749,235 		JBrowse link
G Il12a interleukin 12A decreases expression ISO casticin results in decreased expression of IL12A mRNA CTD PMID:27862857 NCBI chr 2:165,076,945...165,083,996
Ensembl chr 2:165,076,607...165,084,318 		JBrowse link
G Il6 interleukin 6 decreases expression ISO casticin results in decreased expression of IL6 mRNA CTD PMID:27862857 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Ints6 integrator complex subunit 6 decreases expression ISO casticin results in decreased expression of INTS6 mRNA CTD PMID:28444820 NCBI chr15:45,844,050...45,929,996
Ensembl chr15:45,858,608...45,947,030 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 increases expression ISO casticin results in increased expression of IRAK4 mRNA CTD PMID:27862857 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652 		JBrowse link
G Irf2bp2 interferon regulatory factor 2 binding protein 2 decreases expression ISO casticin results in decreased expression of IRF2BP2 mRNA CTD PMID:28444820 NCBI chr19:59,497,021...59,502,298
Ensembl chr19:59,499,876...59,502,161 		JBrowse link
G Kcnh2 potassium voltage-gated channel subfamily H member 2 decreases expression ISO casticin results in decreased expression of KCNH2 mRNA CTD PMID:28444820 NCBI chr 4:7,355,066...7,387,282
Ensembl chr 4:7,355,574...7,387,253 		JBrowse link
G Kctd9 potassium channel tetramerization domain containing 9 decreases expression ISO casticin results in decreased expression of KCTD9 mRNA CTD PMID:28444820 NCBI chr15:44,411,591...44,439,645
Ensembl chr15:44,411,865...44,439,236 		JBrowse link
G Kirrel3 kirre like nephrin family adhesion molecule 3 decreases expression ISO casticin results in decreased expression of KIRREL3 mRNA CTD PMID:28444820 NCBI chr 8:35,692,525...36,254,755
Ensembl chr 8:36,125,999...36,254,753 		JBrowse link
G Klf9 Kruppel-like factor 9 decreases expression ISO casticin results in decreased expression of KLF9 mRNA CTD PMID:28444820 NCBI chr 1:240,908,483...240,933,198
Ensembl chr 1:240,908,483...240,933,198 		JBrowse link
G Krt16 keratin 16 increases expression ISO casticin results in increased expression of KRT16 mRNA CTD PMID:28444820 NCBI chr10:88,149,210...88,152,167
Ensembl chr10:88,149,345...88,152,064 		JBrowse link
G Ldhb lactate dehydrogenase B decreases expression ISO casticin results in decreased expression of LDHB mRNA CTD PMID:27862857 NCBI chr 4:176,701,980...176,719,999
Ensembl chr 4:176,701,983...176,720,012 		JBrowse link
G Lef1 lymphoid enhancer binding factor 1 decreases expression ISO casticin results in decreased expression of LEF1 mRNA CTD PMID:27862857 NCBI chr 2:236,232,115...236,345,061
Ensembl chr 2:236,233,239...236,345,056 		JBrowse link
G Lhfpl6 LHFPL tetraspan subfamily member 6 increases expression ISO casticin results in increased expression of LHFP mRNA CTD PMID:28444820 NCBI chr 2:142,262,236...142,461,980
Ensembl chr 2:142,262,236...142,461,980 		JBrowse link
G Limch1 LIM and calponin homology domains 1 increases expression ISO casticin results in increased expression of LIMCH1 mRNA CTD PMID:28444820 NCBI chr14:42,760,363...43,072,976
Ensembl chr14:42,762,587...43,072,843 		JBrowse link
G LOC102553180 protocadherin alpha-1-like increases expression ISO casticin results in increased expression of PCDHA1 mRNA CTD PMID:28444820 NCBI chr18:29,824,891...29,839,850 JBrowse link
G Lpl lipoprotein lipase decreases expression ISO casticin results in decreased expression of LPL mRNA CTD PMID:27862857 NCBI chr16:22,537,687...22,561,487
Ensembl chr16:22,537,056...22,561,496 		JBrowse link
G Lrp5 LDL receptor related protein 5 increases expression ISO casticin results in increased expression of LRP5 mRNA CTD PMID:27862857 NCBI chr 1:218,816,833...218,920,147
Ensembl chr 1:218,816,841...218,920,094 		JBrowse link
G Ltv1 LTV1 ribosome biogenesis factor decreases expression ISO casticin results in decreased expression of LTV1 mRNA CTD PMID:28444820 NCBI chr 1:7,323,043...7,335,766
Ensembl chr 1:7,323,040...7,335,936 		JBrowse link
G Maf MAF bZIP transcription factor decreases expression ISO casticin results in decreased expression of MAF mRNA CTD PMID:28444820 NCBI chr19:48,179,826...48,200,995
Ensembl chr19:48,194,804...48,196,748 		JBrowse link
G Magoh mago homolog, exon junction complex subunit decreases expression ISO casticin results in decreased expression of MAGOH mRNA CTD PMID:28444820 NCBI chr 5:127,480,465...127,487,617
Ensembl chr 5:127,480,485...127,487,603 		JBrowse link
G Map3k7 mitogen activated protein kinase kinase kinase 7 increases expression ISO casticin results in increased expression of MAP3K7 mRNA CTD PMID:27862857 NCBI chr 5:47,183,142...47,244,424
Ensembl chr 5:47,186,558...47,244,416 		JBrowse link
G Mapre2 microtubule-associated protein, RP/EB family, member 2 increases expression ISO casticin results in increased expression of MAPRE2 mRNA CTD PMID:28444820 NCBI chr18:14,814,149...15,780,290 JBrowse link
G Mark3 microtubule affinity regulating kinase 3 decreases expression ISO casticin results in decreased expression of MARK3 mRNA CTD PMID:28444820 NCBI chr 6:136,040,957...136,129,780
Ensembl chr 6:136,041,777...136,129,661 		JBrowse link
G Max MYC associated factor X decreases expression ISO casticin results in decreased expression of MAX mRNA CTD PMID:28444820 NCBI chr 6:99,984,260...100,011,460
Ensembl chr 6:99,984,260...100,011,388 		JBrowse link
G Mbp myelin basic protein increases expression ISO casticin results in increased expression of MBP mRNA CTD PMID:28444820 NCBI chr18:79,326,738...79,437,310
Ensembl chr18:79,326,738...79,437,310 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression ISO casticin results in decreased expression of MCL1 protein CTD PMID:27862857 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Mdc1 mediator of DNA damage checkpoint 1 increases expression ISO casticin results in increased expression of MDC1 protein CTD PMID:29098808 NCBI chr20:3,405,017...3,419,831
Ensembl chr20:3,404,711...3,419,831 		JBrowse link
G Mecom MDS1 and EVI1 complex locus decreases expression ISO casticin results in decreased expression of MECOM mRNA CTD PMID:28444820 NCBI chr 2:117,396,084...117,993,604
Ensembl chr 2:117,396,007...117,454,769 		JBrowse link
G Mest mesoderm specific transcript increases expression ISO casticin results in increased expression of MEST mRNA CTD PMID:28444820 NCBI chr 4:58,052,786...58,063,227
Ensembl chr 4:58,053,041...58,063,138 		JBrowse link
G Mettl3 methyltransferase-like 3 decreases expression ISO casticin results in decreased expression of METTL3 mRNA CTD PMID:28444820 NCBI chr15:28,710,299...28,721,491
Ensembl chr15:28,710,300...28,721,127 		JBrowse link
G Mir148a microRNA 148a increases expression
multiple interactions		 ISO casticin results in increased expression of MIR148A mRNA
casticin affects the reaction [MIR148A mRNA affects the activity of DNMT1 protein]; casticin affects the reaction [MIR148A mRNA affects the expression of CD44 mRNA]; casticin affects the reaction [MIR148A mRNA affects the expression of DNMT1 mRNA]; casticin affects the reaction [MIR148A mRNA results in increased expression of MIR148A mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased activity of DNMT1 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of BMI1 mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of CD44 protein]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of EPCAM mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA affects the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA affects the reaction [casticin results in decreased expression of DNMT1 mRNA]; MIR148A mRNA affects the reaction [casticin results in increased expression of MIR148A mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased activity of DNMT1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of BMI1 mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of CD44 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of EPCAM mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA]		 CTD PMID:32268151 NCBI chr 4:81,013,269...81,013,365
Ensembl chr 4:81,013,269...81,013,365 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO casticin results in decreased expression of MMP2 mRNA
casticin results in decreased expression of MMP2 protein		 CTD PMID:27862857 PMID:28444820 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression ISO casticin results in decreased expression of MMP9 protein CTD PMID:28444820 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Mplkip M-phase specific PLK1 interacting protein decreases expression ISO casticin results in decreased expression of MPLKIP mRNA CTD PMID:28444820 NCBI chr17:49,955,060...49,990,982
Ensembl chr17:49,955,060...49,991,059 		JBrowse link
G mrpl9 mitochondrial ribosomal protein L9 increases expression ISO casticin results in increased expression of MRPL9 mRNA CTD PMID:28444820 NCBI chr 2:195,684,750...195,689,470
Ensembl chr 2:195,684,210...195,689,052 		JBrowse link
G Muc13 mucin 13, cell surface associated increases expression ISO casticin results in increased expression of MUC13 mRNA CTD PMID:27862857 NCBI chr11:70,185,757...70,223,012
Ensembl chr11:70,185,757...70,211,701 		JBrowse link
G Myd88 MYD88, innate immune signal transduction adaptor increases expression ISO casticin results in increased expression of MYD88 mRNA CTD PMID:27862857 NCBI chr 8:128,022,512...128,027,462
Ensembl chr 8:128,022,473...128,026,841 		JBrowse link
G Myo7a myosin VIIA increases expression ISO casticin results in increased expression of MYO7A mRNA CTD PMID:28444820 NCBI chr 1:163,001,313...163,071,545
Ensembl chr 1:163,001,875...163,071,508 		JBrowse link
G Nanog Nanog homeobox multiple interactions
decreases expression		 ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of NANOG mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of NANOG protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of NANOG mRNA] CTD PMID:32268151 NCBI chr 4:155,531,906...155,539,268
Ensembl chr 4:155,531,906...155,539,268 		JBrowse link
G Nars1 asparaginyl-tRNA synthetase 1 decreases expression ISO casticin results in decreased expression of NARS mRNA CTD PMID:28444820 NCBI chr18:59,986,350...60,002,644
Ensembl chr18:59,986,360...60,002,569 		JBrowse link
G Ndufs4 NADH:ubiquinone oxidoreductase subunit S4 decreases expression ISO casticin results in decreased expression of NDUFS4 mRNA CTD PMID:28444820 NCBI chr 2:46,372,488...46,476,162
Ensembl chr 2:46,372,518...46,476,203 		JBrowse link
G Nfkb1 nuclear factor kappa B subunit 1 decreases expression ISO casticin results in decreased expression of NFKB1 mRNA CTD PMID:27862857 NCBI chr 2:240,773,520...240,890,053
Ensembl chr 2:240,773,456...240,866,689 		JBrowse link
G Nfkb2 nuclear factor kappa B subunit 2 decreases expression ISO casticin results in decreased expression of NFKB2 mRNA CTD PMID:27862857 NCBI chr 1:266,050,634...266,059,277
Ensembl chr 1:266,053,002...266,059,256 		JBrowse link
G Nfkbia NFKB inhibitor alpha decreases expression ISO casticin results in decreased expression of NFKBIA mRNA CTD PMID:27862857 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nfkbib NFKB inhibitor beta decreases expression ISO casticin results in decreased expression of NFKBIB mRNA CTD PMID:27862857 NCBI chr 1:86,941,073...86,948,845
Ensembl chr 1:86,941,074...86,948,845 		JBrowse link
G Nfkbid NFKB inhibitor delta decreases expression ISO casticin results in decreased expression of NFKBID mRNA CTD PMID:27862857 NCBI chr 1:88,883,816...88,892,543
Ensembl chr 1:88,885,937...88,892,615 		JBrowse link
G Nfkbie NFKB inhibitor epsilon decreases expression ISO casticin results in decreased expression of NFKBIE mRNA CTD PMID:27862857 NCBI chr 9:17,828,405...17,835,240
Ensembl chr 9:17,828,408...17,835,240 		JBrowse link
G Nfx1 nuclear transcription factor, X-box binding 1 increases expression ISO casticin results in increased expression of NFX1 mRNA CTD PMID:28444820 NCBI chr 5:57,290,916...57,348,720
Ensembl chr 5:57,291,156...57,348,720 		JBrowse link
G Nkd1 NKD inhibitor of WNT signaling pathway 1 increases expression ISO casticin results in increased expression of NKD1 mRNA CTD PMID:27862857 NCBI chr19:19,434,720...19,509,087
Ensembl chr19:19,436,333...19,509,087 		JBrowse link
G Nme9 NME/NM23 family member 9 increases expression ISO casticin results in increased expression of NME9 mRNA CTD PMID:28444820 NCBI chr 8:107,698,612...107,720,758 JBrowse link
G Nmt1 N-myristoyltransferase 1 decreases expression ISO casticin results in decreased expression of NMT1 mRNA CTD PMID:28444820 NCBI chr10:91,126,689...91,160,721
Ensembl chr10:91,126,689...91,160,720 		JBrowse link
G Nol4l nucleolar protein 4-like decreases expression ISO casticin results in decreased expression of NOL4L mRNA CTD PMID:28444820 NCBI chr 3:148,905,677...148,940,426
Ensembl chr 3:148,909,826...148,932,878 		JBrowse link
G Nop58 NOP58 ribonucleoprotein decreases expression ISO casticin results in decreased expression of NOP58 mRNA CTD PMID:28444820 NCBI chr 9:66,495,881...66,520,521
Ensembl chr 9:66,495,832...66,519,788 		JBrowse link
G Npas3 neuronal PAS domain protein 3 decreases expression ISO casticin results in decreased expression of NPAS3 mRNA CTD PMID:28444820 NCBI chr 6:74,081,995...74,913,025 JBrowse link
G Nrg3 neuregulin 3 decreases expression ISO casticin results in decreased expression of NRG3 mRNA CTD PMID:27862857 NCBI chr16:15,763,031...16,932,208
Ensembl chr16:15,764,632...15,798,974 		JBrowse link
G Nup205 nucleoporin 205 decreases expression ISO casticin results in decreased expression of NUP205 mRNA CTD PMID:28444820 NCBI chr 4:62,703,779...62,773,931
Ensembl chr 4:62,703,779...62,773,923 		JBrowse link
G Nup37 nucleoporin 37 decreases expression ISO casticin results in decreased expression of NUP37 mRNA CTD PMID:28444820 NCBI chr 7:28,715,299...28,750,978
Ensembl chr 7:28,701,690...28,743,326 		JBrowse link
G Olig2 oligodendrocyte transcription factor 2 decreases expression ISO casticin results in decreased expression of OLIG2 mRNA CTD PMID:27862857 NCBI chr11:31,389,514...31,392,890
Ensembl chr11:31,389,514...31,392,890 		JBrowse link
G Orc5 origin recognition complex, subunit 5 decreases expression ISO casticin results in decreased expression of ORC5 mRNA CTD PMID:28444820 NCBI chr 4:9,160,050...9,223,998
Ensembl chr 4:9,160,067...9,223,997 		JBrowse link
G Otub2 OTU deubiquitinase, ubiquitin aldehyde binding 2 decreases expression ISO casticin results in decreased expression of OTUB2 mRNA CTD PMID:28444820 NCBI chr 6:127,282,445...127,301,086
Ensembl chr 6:127,282,466...127,301,083 		JBrowse link
G P2rx7 purinergic receptor P2X 7 increases expression ISO casticin results in increased expression of P2RX7 mRNA CTD PMID:28444820 NCBI chr12:39,353,613...39,396,042
Ensembl chr12:39,353,613...39,396,042 		JBrowse link
G Paip1 poly(A) binding protein interacting protein 1 decreases expression ISO casticin results in decreased expression of PAIP1 mRNA CTD PMID:28444820 NCBI chr 2:52,300,921...52,328,212
Ensembl chr 2:52,301,798...52,328,205 		JBrowse link
G Pak3 p21 (RAC1) activated kinase 3 decreases expression ISO casticin results in decreased expression of PAK3 mRNA CTD PMID:27862857 NCBI chr  X:114,784,452...115,042,683
Ensembl chr  X:114,929,029...115,036,669 		JBrowse link
G Papola poly (A) polymerase alpha decreases expression ISO casticin results in decreased expression of PAPOLA mRNA CTD PMID:28444820 NCBI chr 6:129,609,068...129,662,002
Ensembl chr 6:129,609,074...129,661,531 		JBrowse link
G Pcdha1 protocadherin alpha 1 increases expression ISO casticin results in increased expression of PCDHA1 mRNA CTD PMID:28444820 NCBI chr18:29,951,094...30,215,896 JBrowse link
G Phf10 PHD finger protein 10 decreases expression ISO casticin results in decreased expression of PHF10 mRNA CTD PMID:28444820 NCBI chr 1:56,951,516...56,967,893
Ensembl chr 1:56,951,518...56,967,895 		JBrowse link
G Picalm phosphatidylinositol binding clathrin assembly protein decreases expression ISO casticin results in decreased expression of PICALM mRNA CTD PMID:28444820 NCBI chr 1:154,377,229...154,458,966
Ensembl chr 1:154,377,247...154,458,425 		JBrowse link
G Plau plasminogen activator, urokinase decreases expression ISO casticin results in decreased expression of PLAU protein CTD PMID:28444820 NCBI chr15:3,644,296...3,650,765
Ensembl chr15:3,644,769...3,650,819 		JBrowse link
G Pmp22 peripheral myelin protein 22 increases expression ISO casticin results in increased expression of PMP22 mRNA CTD PMID:28444820 NCBI chr10:49,538,588...49,568,583
Ensembl chr10:49,538,588...49,568,583 		JBrowse link
G Pou5f1 POU class 5 homeobox 1 multiple interactions
decreases expression		 ISO casticin promotes the reaction [MIR148A mRNA results in decreased expression of POU5F1 mRNA]; DNMT1 protein inhibits the reaction [casticin results in decreased expression of POU5F1 protein]; MIR148A mRNA promotes the reaction [casticin results in decreased expression of POU5F1 mRNA] CTD PMID:32268151 NCBI chr20:3,747,231...3,751,994
Ensembl chr20:3,747,221...3,751,994 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta decreases expression ISO casticin results in decreased expression of PPARD mRNA CTD PMID:27862857 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma increases expression ISO casticin results in increased expression of PPARG mRNA CTD PMID:27862857 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Ppargc1a PPARG coactivator 1 alpha decreases expression ISO casticin results in decreased expression of PPARGC1A mRNA CTD PMID:28444820 NCBI chr14:63,095,291...63,190,688
Ensembl chr14:63,095,720...63,187,009 		JBrowse link
G Ppp1r11 protein phosphatase 1, regulatory (inhibitor) subunit 11 decreases expression ISO casticin results in decreased expression of PPP1R11 mRNA CTD PMID:28444820 NCBI chr20:2,094,931...2,098,438
Ensembl chr20:2,094,931...2,098,433 		JBrowse link
G Ppp6r3 protein phosphatase 6, regulatory subunit 3 decreases expression ISO casticin results in decreased expression of PPP6R3 mRNA CTD PMID:28444820 NCBI chr 1:218,695,738...218,810,139
Ensembl chr 1:218,695,738...218,810,135 		JBrowse link
G Prkar2b protein kinase cAMP-dependent type II regulatory subunit beta decreases expression ISO casticin results in decreased expression of PRKAR2B mRNA CTD PMID:27862857 NCBI chr 6:51,265,509...51,356,383
Ensembl chr 6:51,265,515...51,356,383 		JBrowse link
G Prkdc protein kinase, DNA-activated, catalytic subunit decreases expression ISO casticin results in decreased expression of PRKDC protein CTD PMID:29098808 NCBI chr11:89,293,547...89,510,948
Ensembl chr11:89,293,696...89,510,871 		JBrowse link
G Prss44 serine protease 44 increases expression ISO casticin results in increased expression of PRSS44 mRNA CTD PMID:28444820 NCBI chr 8:119,083,900...119,097,707
Ensembl chr 8:119,083,900...119,097,707 		JBrowse link
G Ptk2 protein tyrosine kinase 2 decreases expression ISO casticin results in decreased expression of PTK2 protein CTD PMID:28444820 NCBI chr 7:114,436,419...114,611,317
Ensembl chr 7:114,437,361...114,590,119 		JBrowse link
G Ptpra protein tyrosine phosphatase, receptor type, A increases expression ISO casticin results in increased expression of PTPRA mRNA CTD PMID:28444820 NCBI chr 3:122,976,066...123,084,585
Ensembl chr 3:122,976,104...123,084,863 		JBrowse link
G Ptprd protein tyrosine phosphatase, receptor type, D decreases expression ISO casticin results in decreased expression of PTPRD mRNA CTD PMID:28444820 NCBI chr 5:92,862,229...93,514,071
Ensembl chr 5:92,862,267...93,244,202 		JBrowse link
G Ptprf protein tyrosine phosphatase, receptor type, F decreases expression ISO casticin results in decreased expression of PTPRF mRNA CTD PMID:28444820 NCBI chr 5:137,036,936...137,112,930
Ensembl chr 5:137,036,935...137,112,927 		JBrowse link
G Qk quaking decreases expression ISO casticin results in decreased expression of QK mRNA CTD PMID:28444820 NCBI chr 1:50,983,647...51,050,692 JBrowse link
G Rapgef4 Rap guanine nucleotide exchange factor 4 decreases expression ISO casticin results in decreased expression of RAPGEF4 mRNA CTD PMID:28444820 NCBI chr 3:58,632,338...58,925,127
Ensembl chr 3:58,632,476...58,924,038 		JBrowse link
G Rars1 arginyl-tRNA synthetase 1 decreases expression ISO casticin results in decreased expression of RARS mRNA CTD PMID:28444820 NCBI chr10:20,633,630...20,658,074
Ensembl chr10:20,633,632...20,658,100 		JBrowse link
G Rbmx2 RNA binding motif protein, X-linked 2 decreases expression ISO casticin results in decreased expression of RBMX2 mRNA CTD PMID:28444820 NCBI chr  X:135,550,931...135,558,440
Ensembl chr  X:135,550,834...135,558,440 		JBrowse link
G Rcor3 REST corepressor 3 decreases expression ISO casticin results in decreased expression of RCOR3 mRNA CTD PMID:28444820 NCBI chr13:110,822,149...110,864,469
Ensembl chr13:110,822,150...110,864,469 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit decreases expression ISO casticin results in decreased expression of RELA protein CTD PMID:28444820 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rexo2 RNA exonuclease 2 decreases expression ISO casticin results in decreased expression of REXO2 mRNA CTD PMID:28444820 NCBI chr 8:52,802,604...52,814,321
Ensembl chr 8:52,802,595...52,814,321 		JBrowse link
G Rhoa ras homolog family member A decreases expression ISO casticin results in decreased expression of RHOA protein CTD PMID:28444820 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Rpl22l1 ribosomal protein L22 like 1 decreases expression ISO casticin results in decreased expression of RPL22L1 mRNA CTD PMID:28444820 NCBI chr 2:115,362,799...115,364,735
Ensembl chr 2:115,362,799...115,364,729 		JBrowse link
G S100a13 S100 calcium binding protein A13 increases expression ISO casticin results in increased expression of S100A13 mRNA CTD PMID:28444820 NCBI chr 2:189,906,022...189,912,516
Ensembl chr 2:189,906,022...189,912,516 		JBrowse link
G Scn1b sodium voltage-gated channel beta subunit 1 increases expression ISO casticin results in increased expression of SCN1B mRNA CTD PMID:28444820 NCBI chr 1:89,550,738...89,560,469
Ensembl chr 1:89,550,738...89,560,719 		JBrowse link
G Slc31a1 solute carrier family 31 member 1 increases expression ISO casticin results in increased expression of SLC31A1 mRNA CTD PMID:28444820 NCBI chr 5:78,222,504...78,249,358
Ensembl chr 5:78,222,504...78,249,358 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 decreases expression ISO casticin results in decreased expression of SLC6A9 mRNA CTD PMID:28444820 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697 		JBrowse link
G Smad1 SMAD family member 1 increases expression ISO casticin results in increased expression of SMAD1 mRNA CTD PMID:27862857 NCBI chr19:32,182,942...32,248,694
Ensembl chr19:32,188,267...32,248,684 		JBrowse link
G Smad3 SMAD family member 3 increases expression ISO casticin results in increased expression of SMAD3 mRNA CTD PMID:27862857 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Snrpg small nuclear ribonucleoprotein polypeptide G decreases expression ISO casticin results in decreased expression of SNRPG mRNA CTD PMID:28444820 NCBI chr 4:118,167,267...118,174,846
Ensembl chr 4:118,167,294...118,174,842 		JBrowse link
G Snw1 SNW domain containing 1 decreases expression ISO casticin results in decreased expression of SNW1 mRNA CTD PMID:28444820 NCBI chr 6:111,483,698...111,507,782
Ensembl chr 6:111,483,703...111,507,782 		JBrowse link
G Sos1 SOS Ras/Rac guanine nucleotide exchange factor 1 decreases expression ISO casticin results in decreased expression of SOS1 protein CTD PMID:28444820 NCBI chr 6:3,105,443...3,182,977
Ensembl chr 6:3,104,861...3,182,996 		JBrowse link
G Sparc secreted protein acidic and cysteine rich decreases expression
increases expression		 ISO casticin results in decreased expression of SPARC mRNA
casticin results in increased expression of SPARC mRNA		 CTD PMID:27862857 PMID:28444820 NCBI chr10:40,742,390...40,764,232
Ensembl chr10:40,742,400...40,764,185 		JBrowse link
G Sparcl1 SPARC like 1 increases expression ISO casticin results in increased expression of SPARCL1 mRNA CTD PMID:28444820 NCBI chr14:6,994,261...7,025,309
Ensembl chr14:6,994,190...7,025,308 		JBrowse link
G St13 ST13, Hsp70 interacting protein increases expression ISO casticin results in increased expression of ST13 mRNA CTD PMID:28444820 NCBI chr 7:122,585,770...122,635,731
Ensembl chr 7:122,585,771...122,635,731 		JBrowse link
G St3gal3 ST3 beta-galactoside alpha-2,3-sialyltransferase 3 decreases expression ISO casticin results in decreased expression of ST3GAL3 mRNA CTD PMID:28444820 NCBI chr 5:136,765,309...136,965,642
Ensembl chr 5:136,766,208...136,965,191 		JBrowse link
G Strbp spermatid perinuclear RNA binding protein decreases expression ISO casticin results in decreased expression of STRBP mRNA CTD PMID:28444820 NCBI chr 3:21,817,680...21,956,988
Ensembl chr 3:21,828,298...21,904,270 		JBrowse link
G Sugp1 SURP and G patch domain containing 1 decreases expression ISO casticin results in decreased expression of SUGP1 mRNA CTD PMID:28444820 NCBI chr16:21,100,923...21,131,795
Ensembl chr16:21,100,924...21,131,795 		JBrowse link
G Syncrip synaptotagmin binding, cytoplasmic RNA interacting protein decreases expression ISO casticin results in decreased expression of SYNCRIP mRNA CTD PMID:28444820 NCBI chr 8:96,100,692...96,266,342
Ensembl chr 8:96,105,025...96,266,342 		JBrowse link
G Syt9 synaptotagmin 9 decreases expression ISO casticin results in decreased expression of SYT9 mRNA CTD PMID:28444820 NCBI chr 1:171,592,703...171,769,780
Ensembl chr 1:171,592,797...171,769,780 		JBrowse link
G Tab2 TGF-beta activated kinase 1/MAP3K7 binding protein 2 decreases expression ISO casticin results in decreased expression of TAB2 mRNA CTD PMID:27862857 NCBI chr 1:1,999,574...2,017,574
Ensembl chr 1:1,999,596...2,073,896 		JBrowse link
G Tcf7 transcription factor 7 decreases expression ISO casticin results in decreased expression of TCF7 mRNA CTD PMID:28444820 NCBI chr10:37,616,033...37,646,027
Ensembl chr10:37,617,279...37,645,802 		JBrowse link
G Thra thyroid hormone receptor alpha decreases expression ISO casticin results in decreased expression of THRA mRNA CTD PMID:28444820 NCBI chr10:86,657,285...86,684,935
Ensembl chr10:86,657,285...86,684,933 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO casticin results in increased expression of TIMP2 mRNA CTD PMID:28444820 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tlk2 tousled-like kinase 2 decreases expression ISO casticin results in decreased expression of TLK2 mRNA CTD PMID:28444820 NCBI chr10:93,410,181...93,507,277
Ensembl chr10:93,415,399...93,507,277 		JBrowse link
G Tlr4 toll-like receptor 4 decreases expression ISO casticin results in decreased expression of TLR4 mRNA CTD PMID:27862857 NCBI chr 5:82,587,424...82,601,056
Ensembl chr 5:82,587,420...82,601,052 		JBrowse link
G Tmbim4 transmembrane BAX inhibitor motif containing 4 increases expression ISO casticin results in increased expression of TMBIM4 mRNA CTD PMID:27862857 NCBI chr 7:64,987,859...65,002,447
Ensembl chr 7:64,987,859...65,002,455 		JBrowse link
G Tmem45b transmembrane protein 45b increases expression ISO casticin results in increased expression of TMEM45B mRNA CTD PMID:27862857 NCBI chr 8:32,563,872...32,609,212
Ensembl chr 8:32,563,874...32,609,212 		JBrowse link
G Tmsb10 thymosin, beta 10 increases expression ISO casticin results in increased expression of TMSB10 mRNA CTD PMID:28444820 NCBI chr 4:100,882,216...100,883,303
Ensembl chr 4:100,882,216...100,883,275 		JBrowse link
G Tnfsf10 TNF superfamily member 10 increases expression ISO casticin results in increased expression of TNFSF10 protein CTD PMID:27862857 NCBI chr 2:113,008,008...113,026,899
Ensembl chr 2:113,007,549...113,026,899 		JBrowse link
G Tnpo1 transportin 1 decreases expression ISO casticin results in decreased expression of TNPO1 mRNA CTD PMID:28444820 NCBI chr 2:29,056,219...29,126,882
Ensembl chr 2:29,056,219...29,121,104 		JBrowse link
G Tor1aip2 torsin 1A interacting protein 2 decreases expression ISO casticin results in decreased expression of TOR1AIP2 mRNA CTD PMID:28444820 NCBI chr13:73,704,088...73,735,339
Ensembl chr13:73,708,815...73,735,339
Ensembl chr13:73,708,815...73,735,339 		JBrowse link
G Tp53 tumor protein p53 increases expression
decreases expression		 ISO casticin results in increased expression of TP53 protein modified form
casticin results in decreased expression of TP53 protein		 CTD PMID:29098808 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Tpi1 triosephosphate isomerase 1 increases expression ISO casticin results in increased expression of TPI1 mRNA CTD PMID:28444820 NCBI chr 4:157,328,375...157,331,905
Ensembl chr 4:157,328,379...157,331,905 		JBrowse link
G Tpra1 transmembrane protein adipocyte associated 1 increases expression ISO casticin results in increased expression of TPRA1 mRNA CTD PMID:28444820 NCBI chr 4:120,843,374...120,854,534
Ensembl chr 4:120,843,453...120,854,529 		JBrowse link
G Tra2b transformer 2 beta homolog decreases expression ISO casticin results in decreased expression of TRA2B mRNA CTD PMID:28444820 NCBI chr11:82,373,828...82,392,208
Ensembl chr11:82,373,870...82,392,083 		JBrowse link
G Trap1 TNF receptor-associated protein 1 increases expression ISO casticin results in increased expression of TRAP1 mRNA CTD PMID:27862857 NCBI chr10:11,724,032...11,757,682
Ensembl chr10:11,724,032...11,757,681 		JBrowse link
G Trio trio Rho guanine nucleotide exchange factor increases expression ISO casticin results in increased expression of TRIO mRNA CTD PMID:28444820 NCBI chr 2:80,471,398...80,769,313
Ensembl chr 2:80,473,202...80,667,481 		JBrowse link
G Ube2d3 ubiquitin-conjugating enzyme E2D 3 decreases expression ISO casticin results in decreased expression of UBE2D3 mRNA CTD PMID:28444820 NCBI chr 2:240,626,198...240,655,874
Ensembl chr 2:240,627,436...240,655,246 		JBrowse link
G Ube2f ubiquitin-conjugating enzyme E2F (putative) decreases expression ISO casticin results in decreased expression of UBE2F mRNA CTD PMID:28444820 NCBI chr 9:98,394,112...98,428,684
Ensembl chr 9:98,398,128...98,428,128 		JBrowse link
G Ube2w ubiquitin-conjugating enzyme E2W decreases expression ISO casticin results in decreased expression of UBE2W mRNA CTD PMID:28444820 NCBI chr 5:29,798,845...29,812,777 JBrowse link
G Vegfa vascular endothelial growth factor A decreases expression ISO casticin results in decreased expression of VEGFA mRNA CTD PMID:28444820 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
G Vezf1 vascular endothelial zinc finger 1 decreases expression ISO casticin results in decreased expression of VEZF1 mRNA CTD PMID:28444820 NCBI chr10:75,365,763...75,382,014
Ensembl chr10:75,365,822...75,381,555 		JBrowse link
G Vim vimentin decreases expression
increases expression		 ISO casticin results in decreased expression of VIM mRNA
casticin results in increased expression of VIM mRNA		 CTD PMID:27862857 PMID:28444820 NCBI chr17:80,882,715...80,891,200
Ensembl chr17:80,882,666...80,891,212 		JBrowse link
G Vldlr very low density lipoprotein receptor decreases expression ISO casticin results in decreased expression of VLDLR mRNA CTD PMID:28444820 NCBI chr 1:245,236,819...245,273,688
Ensembl chr 1:245,237,736...245,269,205 		JBrowse link
G Wac WW domain containing adaptor with coiled-coil decreases expression ISO casticin results in decreased expression of WAC mRNA CTD PMID:28444820 NCBI chr17:60,887,606...60,946,630
Ensembl chr17:60,888,017...60,946,426 		JBrowse link
G Wee1 WEE1 G2 checkpoint kinase decreases expression ISO casticin results in decreased expression of WEE1 protein CTD PMID:29098808 NCBI chr 1:174,765,228...174,790,882
Ensembl chr 1:174,767,960...174,786,361 		JBrowse link
G Wnt5a Wnt family member 5A decreases expression ISO casticin results in decreased expression of WNT5A mRNA CTD PMID:27862857 NCBI chr16:4,469,451...4,490,271
Ensembl chr16:4,469,468...4,489,860 		JBrowse link
G Wsb1 WD repeat and SOCS box-containing 1 decreases expression ISO casticin results in decreased expression of WSB1 mRNA CTD PMID:28444820 NCBI chr10:66,586,905...66,602,984
Ensembl chr10:66,586,924...66,602,987 		JBrowse link
G Wtap WT1 associated protein decreases expression ISO casticin results in decreased expression of WTAP mRNA CTD PMID:28444820 NCBI chr 1:47,942,500...47,967,633
Ensembl chr 1:47,942,500...47,967,631 		JBrowse link
G Xbp1 X-box binding protein 1 increases expression ISO casticin results in increased expression of XBP1 mRNA CTD PMID:27862857 NCBI chr14:85,753,736...85,758,820
Ensembl chr14:85,753,760...85,758,145 		JBrowse link
G Xiap X-linked inhibitor of apoptosis decreases expression ISO casticin results in decreased expression of XIAP protein CTD PMID:29098808 NCBI chr  X:128,409,425...128,455,786
Ensembl chr  X:128,409,472...128,453,000 		JBrowse link
G Ywhab tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta increases expression ISO casticin results in increased expression of YWHAB protein CTD PMID:29098808 NCBI chr 3:160,391,108...160,399,931
Ensembl chr 3:160,391,106...160,399,931 		JBrowse link
G Ywhag tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, gamma decreases expression ISO casticin results in decreased expression of YWHAG mRNA CTD PMID:28444820 NCBI chr12:23,789,547...23,817,884
Ensembl chr12:23,789,638...23,817,883 		JBrowse link
G Zbtb18 zinc finger and BTB domain containing 18 decreases expression ISO casticin results in decreased expression of ZBTB18 mRNA CTD PMID:28444820 NCBI chr13:95,582,234...95,593,316
Ensembl chr13:95,589,668...95,591,236 		JBrowse link
G Zfhx4 zinc finger homeobox 4 decreases expression ISO casticin results in decreased expression of ZFHX4 mRNA CTD PMID:28444820 NCBI chr 2:98,423,565...98,610,368
Ensembl chr 2:98,423,569...98,610,368 		JBrowse link
G Zfp384 zinc finger protein 384 decreases expression ISO casticin results in decreased expression of ZFP384 mRNA CTD PMID:28444820 NCBI chr 4:157,523,083...157,552,606
Ensembl chr 4:157,523,110...157,552,596 		JBrowse link
G Zfp711 zinc finger protein 711 decreases expression ISO casticin results in decreased expression of ZFP711 mRNA CTD PMID:28444820 NCBI chr  X:84,062,363...84,095,888
Ensembl chr  X:84,064,427...84,096,617 		JBrowse link
G Zfr zinc finger RNA binding protein decreases expression ISO casticin results in decreased expression of ZFR mRNA CTD PMID:28444820 NCBI chr 2:62,150,251...62,213,048
Ensembl chr 2:62,150,251...62,213,048 		JBrowse link
G Zkscan1 zinc finger with KRAB and SCAN domains 1 increases expression ISO casticin results in increased expression of ZKSCAN1 mRNA CTD PMID:28444820 NCBI chr12:19,231,092...19,247,393
Ensembl chr12:19,231,092...19,247,387 		JBrowse link
G Zscan2 zinc finger and SCAN domain containing 2 increases expression ISO casticin results in increased expression of ZSCAN2 mRNA CTD PMID:28444820 NCBI chr 1:142,679,308...142,695,232
Ensembl chr 1:142,679,345...142,695,475 		JBrowse link
G Zswim6 zinc finger, SWIM-type containing 6 increases expression ISO casticin results in increased expression of ZSWIM6 mRNA CTD PMID:28444820 NCBI chr 2:38,978,042...39,042,886
Ensembl chr 2:38,979,865...39,007,976 		JBrowse link
chrysin 5,7-dimethyl ether term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of BAX protein CTD PMID:21554863 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2l1 Bcl2-like 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of BCL2L1 protein] CTD PMID:21554863 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased expression of CASP3 protein] CTD PMID:21554863 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein] CTD PMID:24134915 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Ccnd1 cyclin D1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CCND1 protein] CTD PMID:21554863 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Csnk2b casein kinase 2 beta multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CSNK2B protein] CTD PMID:21554863 NCBI chr20:5,108,692...5,113,675
Ensembl chr20:5,106,890...5,113,112 		JBrowse link
G Ctnnb1 catenin beta 1 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine affects the localization of CTNNB1 protein modified form]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of CTNNB1 mRNA] CTD PMID:21554863 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases activity		 ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of and results in increased activity of CYP1A1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1A1 protein		 CTD PMID:15661813 PMID:15905203 PMID:16484233 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions
decreases activity		 ISO 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1B1 protein]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 protein]
5,7-dimethoxyflavone results in decreased activity of CYP1B1 protein		 CTD PMID:15905203 PMID:16484233 PMID:16530937 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta multiple interactions EXP 5,7-dimethoxyflavone promotes the reaction [Diethylnitrosamine results in increased phosphorylation of GSK3B protein] CTD PMID:21554863 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CCL2 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of CXCL8 protein]; 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO 5,7-dimethoxyflavone inhibits the reaction [IL1B protein results in increased secretion of IL6 protein] CTD PMID:24134915 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of NOS2 protein] CTD PMID:21554863 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of PTGS2 protein] CTD PMID:21554863 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA mRNA]; 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of RELA protein modified form] CTD PMID:21554863 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 mRNA; [5,7-dimethoxyflavone co-treated with Diethylnitrosamine] results in increased expression of TP53 protein CTD PMID:21554863 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Wnt3a Wnt family member 3A multiple interactions EXP 5,7-dimethoxyflavone inhibits the reaction [Diethylnitrosamine results in increased expression of WNT3A protein] CTD PMID:21554863 NCBI chr10:45,598,898...45,643,151
Ensembl chr10:45,598,912...45,638,035 		JBrowse link
chrysosplenetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO chrysosplenetin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 affects activity ISO chrysosplenetin affects the activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
cirsiliol term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity
increases metabolic processing
increases expression		 ISO cirsiliol results in decreased activity of CYP1A1 protein
CYP1A1 protein results in increased metabolism of cirsiliol
cirsiliol results in increased expression of CYP1A1 mRNA		 CTD PMID:19601638 PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression
increases metabolic processing
decreases activity		 ISO cirsiliol results in increased expression of CYP1B1 mRNA
CYP1B1 protein results in increased metabolism of cirsiliol
cirsiliol results in decreased activity of CYP1B1 protein		 CTD PMID:19601638 PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
diosmetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO diosmetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1A1 protein CTD PMID:10781868 PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO diosmetin results in decreased activity of CYP1A2 protein CTD PMID:28867436 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP1B1 protein CTD PMID:10781868 PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO diosmetin results in decreased activity of CYP2C19 protein CTD PMID:28867436 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2c79 cytochrome P450, family 2, subfamily c, polypeptide 79 decreases activity ISO diosmetin results in decreased activity of CYP2C8 protein CTD PMID:28867436 NCBI chr 1:147,236,480...147,307,988 JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 decreases activity ISO diosmetin results in decreased activity of CYP2E1 protein CTD PMID:28867436 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions ISO diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 1-hydroxymethylmidazolam]; diosmetin inhibits the reaction [CYP3A4 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 multiple interactions ISO diosmetin inhibits the reaction [CYP3A5 protein results in increased chemical synthesis of 4-hydroxymidazolam] CTD PMID:18191104 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of NFKBIA protein] CTD PMID:16934226 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:16934226 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO diosmetin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Slc16a1 solute carrier family 16 member 1 multiple interactions EXP [diosmetin results in decreased activity of SLC16A1 protein] which results in decreased uptake of Sodium Oxybate CTD PMID:17108059 NCBI chr 2:207,108,552...207,129,352
Ensembl chr 2:207,108,552...207,128,554 		JBrowse link
G Slc22a1 solute carrier family 22 member 1 multiple interactions ISO diosmetin inhibits the reaction [SLC22A1 protein results in increased uptake of 1-Methyl-4-phenylpyridinium] CTD PMID:28867436 NCBI chr 1:48,273,639...48,300,645
Ensembl chr 1:48,273,611...48,300,655 		JBrowse link
G Slco1a4 solute carrier organic anion transporter family, member 1a4 multiple interactions ISO diosmetin inhibits the reaction [SLCO1A2 protein results in increased uptake of Rosuvastatin Calcium] CTD PMID:28867436 NCBI chr 4:175,969,549...176,026,227
Ensembl chr 4:175,969,549...176,026,163 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO diosmetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein] CTD PMID:16934226 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
diosmin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ahr aryl hydrocarbon receptor multiple interactions ISO Diosmin binds to and results in increased activity of AHR protein CTD PMID:14644660 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Bad BCL2-associated agonist of cell death multiple interactions EXP Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of BAD protein] CTD PMID:21477647 NCBI chr 1:222,198,516...222,207,459
Ensembl chr 1:222,198,534...222,207,453 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of BAX protein] CTD PMID:32061149 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions EXP
ISO		 [Diosmin co-treated with Lipopolysaccharides] results in increased expression of BCL2 protein
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of BCL2 protein]		 CTD PMID:21477647 PMID:32061149 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP
ISO		 Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP3 protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased activity of CASP3 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of CASP3 protein]		 CTD PMID:21477647 PMID:23665045 PMID:32061149 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp7 caspase 7 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP7 protein] CTD PMID:23665045 NCBI chr 1:277,190,557...277,242,779
Ensembl chr 1:277,190,964...277,242,774 		JBrowse link
G Casp9 caspase 9 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of CASP9 protein] CTD PMID:23665045 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of CAT protein]; Diosmin inhibits the reaction [[Streptozocin co-treated with Niacinamide] results in decreased activity of CAT protein] CTD PMID:22056647 PMID:23665045 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of CYP2E1 protein] CTD PMID:23665045 NCBI chr 1:213,511,892...213,522,195
Ensembl chr 1:213,511,874...213,535,542 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP
ISO		 Diosmin inhibits the reaction [2-Acetylaminofluorene results in decreased expression of GSR protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSR protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of IL6 protein] CTD PMID:32061149 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mki67 marker of proliferation Ki-67 multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of MKI67 protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of MKI67 protein] CTD PMID:23665045 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of NOS2 protein] CTD PMID:23665045 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased cleavage of PARP1 protein] CTD PMID:32061149 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pcna proliferating cell nuclear antigen multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of PCNA protein]; Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PCNA protein] CTD PMID:23665045 NCBI chr 3:124,880,698...124,884,570
Ensembl chr 3:124,880,698...124,884,570 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP
ISO		 Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of PTGS2 protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of PTGS2 protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of RELA protein] CTD PMID:32061149 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased expression of TNF protein]; Diosmin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] CTD PMID:21477647 PMID:23665045 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions EXP Diosmin inhibits the reaction [[Diethylnitrosamine co-treated with 2-Acetylaminofluorene] results in increased expression of TP53 protein] CTD PMID:23665045 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Xdh xanthine dehydrogenase multiple interactions EXP
ISO		 Diosmin inhibits the reaction [2-Acetylaminofluorene results in increased activity of XDH protein]
Diosmin inhibits the reaction [Benzo(a)pyrene results in increased expression of XDH protein]		 CTD PMID:23665045 PMID:32061149 NCBI chr 6:25,149,570...25,211,273
Ensembl chr 6:25,149,235...25,211,494 		JBrowse link
eupatilin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ccl2 C-C motif chemokine ligand 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of CCL2 mRNA] CTD PMID:21565208 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity
multiple interactions		 ISO eupatilin results in increased activity of CYP3A4 protein
[[eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [eupatilin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam		 CTD PMID:31756459 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL1B mRNA] CTD PMID:21565208 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of IL6 mRNA] CTD PMID:21565208 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:21565208 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of NOS2 protein] CTD PMID:21565208 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 mRNA]; eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of PTGS2 protein] CTD PMID:21565208 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 affects the localization of RELA protein] CTD PMID:21565208 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO eupatilin inhibits the reaction [lipopolysaccharide, E. coli O26-B6 results in increased expression of TNF mRNA] CTD PMID:21565208 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
eupatorin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases response to substance
increases metabolic processing
decreases activity
increases expression		 ISO CYP1A1 protein results in increased susceptibility to eupatorin
CYP1A1 protein results in increased metabolism of eupatorin analog
eupatorin analog results in decreased activity of CYP1A1 protein
eupatorin results in increased expression of CYP1A1 mRNA		 CTD PMID:18454852 PMID:19601638 PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression
decreases activity		 ISO CYP1B1 protein results in increased metabolism of eupatorin analog
eupatorin results in increased expression of CYP1B1 mRNA
eupatorin results in decreased activity of CYP1B1 protein		 CTD PMID:19601638 PMID:21482471 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO eupatorin results in decreased activity of CYP2C19 protein CTD PMID:21093571 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp2d4 cytochrome P450, family 2, subfamily d, polypeptide 4 decreases activity ISO eupatorin results in decreased activity of CYP2D6 protein CTD PMID:21276781 NCBI chr 7:123,599,264...123,608,436
Ensembl chr 7:123,599,266...123,608,436 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO eupatorin results in decreased activity of CYP3A4 protein CTD PMID:21276781 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
gardenin B term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bcl2 BCL2, apoptosis regulator decreases expression ISO gardenin B results in decreased expression of BCL2 protein CTD PMID:27423764 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp2 caspase 2 multiple interactions ISO gardenin B results in increased cleavage of and results in increased activity of CASP2 protein CTD PMID:27423764 NCBI chr 4:71,652,358...71,670,228
Ensembl chr 4:71,652,354...71,670,239 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO gardenin B results in increased cleavage of and results in increased activity of CASP3 protein CTD PMID:27423764 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO gardenin B results in increased cleavage of and results in increased activity of CASP8 protein CTD PMID:27423764 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 multiple interactions ISO gardenin B results in increased cleavage of and results in increased activity of CASP9 protein CTD PMID:27423764 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO gardenin B results in increased cleavage of PARP1 protein CTD PMID:27423764 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
genkwanin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
decreases activity		 ISO CYP1A1 protein results in increased metabolism of genkwanin
genkwanin results in decreased activity of CYP1A1 protein		 CTD PMID:19666078 PMID:21482471 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of genkwanin CTD PMID:19666078 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
multiple interactions		 ISO CYP1B1 protein results in increased metabolism of genkwanin
[CYP1B1 protein results in increased metabolism of genkwanin] which results in increased chemical synthesis of Apigenin		 CTD PMID:19666078 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
ginkgetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in increased expression of BAX protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased expression of BAX protein]		 CTD PMID:25968939 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in decreased expression of BCL2 protein]
ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of BCL2 protein]		 CTD PMID:25968939 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenylpyridinium results in increased cleavage of CASP3 protein] CTD PMID:25968939 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Ftl1 ferritin light chain 1 decreases expression ISO ginkgetin results in decreased expression of FTL1 protein
ginkgetin results in decreased expression of FTL protein		 CTD PMID:25968939 NCBI chr 1:101,448,190...101,450,034
Ensembl chr 1:101,448,346...101,449,829 		JBrowse link
G Tfrc transferrin receptor increases expression ISO ginkgetin results in increased expression of TFRC protein CTD PMID:25968939 NCBI chr11:71,397,423...71,419,263
Ensembl chr11:71,397,383...71,419,223 		JBrowse link
G Th tyrosine hydroxylase multiple interactions ISO ginkgetin inhibits the reaction [1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine results in decreased expression of TH protein] CTD PMID:25968939 NCBI chr 1:216,073,034...216,080,287
Ensembl chr 1:216,073,031...216,080,287 		JBrowse link
hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:81,330,845...81,344,488
Ensembl chr11:81,330,293...81,344,488 		JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:91,363,492...91,366,164
Ensembl chr 1:91,363,492...91,366,164 		JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:215,856,967...215,858,034
Ensembl chr 1:215,856,971...215,858,034 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity		 EXP [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344 		JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,321,315...1,379,202
Ensembl chr  X:1,321,315...1,379,198 		JBrowse link
isorhamnetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases transport
increases expression		 ISO ABCB1 protein results in increased transport of 3-methylquercetin
3-methylquercetin results in increased expression of ABCB1 mRNA		 CTD PMID:15969930 PMID:26238175 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO 3-methylquercetin results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Acta2 actin alpha 2, smooth muscle multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]		 CTD PMID:27151496 NCBI chr 1:252,537,614...252,550,394
Ensembl chr 1:252,537,615...252,550,394 		JBrowse link
G Agt angiotensinogen multiple interactions EXP 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein] CTD PMID:17374653 NCBI chr19:57,321,594...57,333,460
Ensembl chr19:57,321,640...57,333,433 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of AHR protein] CTD PMID:19794518 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation
multiple interactions		 ISO
EXP		 3-methylquercetin results in decreased phosphorylation of AKT1 protein
3-methylquercetin affects the reaction [Hydrogen Peroxide results in increased phosphorylation of AKT1 protein]		 CTD PMID:12826665 PMID:19222219 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 3-methylquercetin results in decreased expression of BCL2 mRNA; 3-methylquercetin results in decreased expression of BCL2 protein CTD PMID:22992727 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Bcl2l1 Bcl2-like 1 decreases expression ISO 3-methylquercetin results in decreased expression of BCL2L1 mRNA; 3-methylquercetin results in decreased expression of BCL2L1 protein CTD PMID:22992727 NCBI chr 3:148,259,594...148,314,191
Ensembl chr 3:148,259,596...148,313,810 		JBrowse link
G Casp3 caspase 3 decreases expression
multiple interactions
increases activity		 ISO
EXP		 3-methylquercetin results in decreased expression of CASP3 protein
3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased activity of CASP3 protein]
3-methylquercetin results in increased activity of CASP3 protein		 CTD PMID:12826665 PMID:19222219 PMID:22992727 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp9 caspase 9 decreases expression ISO 3-methylquercetin results in decreased expression of CASP9 protein CTD PMID:22992727 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Cat catalase multiple interactions EXP 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in decreased activity of CAT protein]; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of CAT protein CTD PMID:19222219 PMID:25716194 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 multiple interactions ISO [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of CCL3 mRNA CTD PMID:20579867 NCBI chr10:70,869,516...70,871,066
Ensembl chr10:70,869,513...70,871,066 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO 3-methylquercetin results in decreased expression of CCND1 mRNA; 3-methylquercetin results in decreased expression of CCND1 protein CTD PMID:22992727 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Col1a1 collagen type I alpha 1 chain multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA] CTD PMID:27151496 NCBI chr10:82,745,801...82,762,790
Ensembl chr10:82,745,801...82,762,789 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin co-treated with ginkgolide A co-treated with ginkgolide B co-treated with ginkgolide C co-treated with ginkgolide J co-treated with bilobalide] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] affects the activity of CYP1A1 protein; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Benzo(a)pyrene results in increased activity of CYP1A1 protein]; [Quercetin co-treated with kaempferol co-treated with 3-methylquercetin] inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of CYP1A1 protein] CTD PMID:21329749 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 decreases expression ISO 3-methylquercetin results in decreased expression of CYP1B1 mRNA CTD PMID:19794518 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO 3-methylquercetin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:18436224 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Esr1 estrogen receptor 1 affects binding ISO 3-methylquercetin binds to ESR1 protein CTD PMID:14706564 NCBI chr 1:41,192,029...41,594,799
Ensembl chr 1:41,192,824...41,594,796 		JBrowse link
G Esr2 estrogen receptor 2 affects binding ISO 3-methylquercetin binds to ESR2 protein CTD PMID:14706564 NCBI chr 6:99,163,953...99,214,711
Ensembl chr 6:99,164,357...99,214,251 		JBrowse link
G Gclc glutamate-cysteine ligase, catalytic subunit multiple interactions
increases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of GCLC protein
3-methylquercetin results in increased expression of GCLC mRNA; 3-methylquercetin results in increased expression of GCLC protein		 CTD PMID:24211276 PMID:25716194 NCBI chr 8:85,059,051...85,097,471
Ensembl chr 8:85,059,051...85,097,468 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of GPT protein] CTD PMID:27151496 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions
increases expression		 ISO
EXP		 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
[quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 mRNA; [quercetin 3-O-glucuronide co-treated with 3-methylquercetin co-treated with Quercetin] results in increased expression of HMOX1 protein
3-methylquercetin results in increased expression of HMOX1 mRNA; 3-methylquercetin results in increased expression of HMOX1 protein
3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in decreased expression of HMOX1 mRNA]; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein		 CTD PMID:24211276 PMID:24337631 PMID:25716194 PMID:27151496 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL1B protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL1B protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL1B mRNA		 CTD PMID:20579867 PMID:23774260 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of IL6 protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of IL6 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of IL6 mRNA		 CTD PMID:20579867 PMID:23774260 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions EXP 3-methylquercetin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of MAPK8 protein] CTD PMID:19222219 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mir155 microRNA 155 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of MIR155 mRNA] CTD PMID:20579867 NCBI chr11:24,176,603...24,176,667
Ensembl chr11:24,176,603...24,176,667 		JBrowse link
G Ncf1 neutrophil cytosolic factor 1 multiple interactions EXP 3-methylquercetin inhibits the reaction [AGT protein results in increased expression of NCF1 protein]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 mRNA]; 3-methylquercetin inhibits the reaction [EDN1 protein results in increased expression of NCF1 protein] CTD PMID:17374653 PMID:18436224 NCBI chr12:25,497,104...25,506,300
Ensembl chr12:25,497,104...25,506,300 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 affects response to substance
multiple interactions
affects localization
increases activity		 ISO NFE2L2 protein affects the susceptibility to 3-methylquercetin
2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; 3-methylquercetin affects the localization of and results in increased phosphorylation of and results in increased activity of NFE2L2 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased abundance of Glutathione; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA; [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; dorsomorphin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein]; rottlerin inhibits the reaction [[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein]
3-methylquercetin affects the localization of NFE2L2 protein
[3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of GCLC protein; [3-methylquercetin results in increased activity of NFE2L2 protein] which results in increased expression of HMOX1 protein; NFE2L2 protein affects the reaction [3-methylquercetin results in decreased susceptibility to tert-Butylhydroperoxide]		 CTD PMID:24211276 PMID:27151496 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:23774260 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO 3-methylquercetin inhibits the reaction [[Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein] which results in increased chemical synthesis of Nitric Oxide]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased activity of NOS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; [3-methylquercetin co-treated with Lipopolysaccharides] affects the expression of NOS2 mRNA CTD PMID:16213685 PMID:18178435 PMID:18274639 PMID:20579867 PMID:23774260 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipids results in decreased expression of NOS3] CTD PMID:16891912 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions ISO [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of NQO1 mRNA CTD PMID:24211276 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO 3-methylquercetin binds to and results in increased activity of NR1I2 protein
3-methylquercetin results in increased activity of NR1I2 protein		 CTD PMID:26238175 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Olr1 oxidized low density lipoprotein receptor 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipids results in increased expression of OLR1] CTD PMID:16891912 NCBI chr 4:163,239,853...163,261,937
Ensembl chr 4:163,239,849...163,261,958 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage ISO 3-methylquercetin results in increased cleavage of PARP1 protein CTD PMID:22992727 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 decreases expression ISO 3-methylquercetin results in decreased expression of PECAM1 protein CTD PMID:22992727 NCBI chr10:94,850,971...94,913,202 JBrowse link
G Pon1 paraoxonase 1 increases expression ISO 3-methylquercetin results in increased expression of PON1 mRNA CTD PMID:20228421 NCBI chr 4:30,249,749...30,276,297
Ensembl chr 4:30,249,742...30,276,372 		JBrowse link
G Pon2 paraoxonase 2 increases expression ISO 3-methylquercetin results in increased expression of PON2 mRNA CTD PMID:19865538 NCBI chr 4:30,344,705...30,380,119
Ensembl chr 4:30,344,709...30,380,119 		JBrowse link
G Ppard peroxisome proliferator-activated receptor delta increases activity ISO 3-methylquercetin results in increased activity of PPARD protein CTD PMID:22992727 NCBI chr20:7,818,289...7,883,482
Ensembl chr20:7,818,289...7,885,333 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions
increases expression		 ISO 2-chloro-5-nitrobenzanilide inhibits the reaction [3-methylquercetin results in increased activity of PPARG protein]; 3-methylquercetin binds to and results in increased activity of PPARG protein
3-methylquercetin results in increased expression of PPARG protein		 CTD PMID:22992727 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkcd protein kinase C, delta increases phosphorylation ISO 3-methylquercetin results in increased phosphorylation of PRKCD protein CTD PMID:24211276 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Ptges prostaglandin E synthase multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGES mRNA] CTD PMID:21341175 NCBI chr 3:9,727,408...9,738,752
Ensembl chr 3:9,727,408...9,738,752 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions
decreases activity		 ISO
EXP		 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein]; 3-methylquercetin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of PTGS2 protein]; Acetylcysteine promotes the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]; tin protoporphyrin IX inhibits the reaction [3-methylquercetin inhibits the reaction [lipopolysaccharide, E coli O55-B5 results in increased expression of PTGS2 protein]]
3-methylquercetin results in decreased activity of PTGS2 protein
3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of PTGS2 protein]		 CTD PMID:15292928 PMID:21341175 PMID:24337631 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of and results in increased activity of RELA protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides affects the localization of RELA protein] CTD PMID:18274639 PMID:20579867 PMID:23774260 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Serpine1 serpin family E member 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]
3-methylquercetin inhibits the reaction [Carbon Tetrachloride results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]		 CTD PMID:27151496 NCBI chr12:22,641,104...22,651,482
Ensembl chr12:22,641,104...22,651,482 		JBrowse link
G Sesn2 sestrin 2 multiple interactions ISO [3-methylquercetin affects the localization of and results in increased activity of NFE2L2 protein] which results in increased expression of SESN2 mRNA CTD PMID:24211276 NCBI chr 5:150,684,891...150,703,846
Ensembl chr 5:150,684,133...150,704,117 		JBrowse link
G Smad2 SMAD family member 2 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein] CTD PMID:27151496 NCBI chr18:72,550,107...72,612,078
Ensembl chr18:72,550,219...72,612,078 		JBrowse link
G Smad3 SMAD family member 3 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr 8:68,569,530...68,678,349
Ensembl chr 8:68,569,530...68,678,349 		JBrowse link
G Tff1 trefoil factor 1 increases expression ISO 3-methylquercetin results in increased expression of TFF1 mRNA CTD PMID:14706564 NCBI chr20:9,892,124...9,895,984
Ensembl chr20:9,892,124...9,895,984 		JBrowse link
G Tgfb1 transforming growth factor, beta 1 multiple interactions ISO 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of ACTA2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of COL1A1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD2 protein]; 3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased expression of SERPINE1 mRNA]]; NFE2L2 protein affects the reaction [3-methylquercetin inhibits the reaction [TGFB1 protein results in increased phosphorylation of SMAD3 protein]] CTD PMID:27151496 NCBI chr 1:82,480,875...82,497,196
Ensembl chr 1:82,480,195...82,497,199 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP
ISO		 3-methylquercetin inhibits the reaction [Carrageenan results in increased expression of TNF protein]
3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of TNF protein]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 3-methylquercetin inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]		 CTD PMID:20579867 PMID:23774260 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tyr tyrosinase increases expression ISO 3-methylquercetin results in increased expression of TYR protein CTD PMID:24853321 NCBI chr 1:151,012,598...151,106,802
Ensembl chr 1:151,012,598...151,106,802 		JBrowse link
G Tyrp1 tyrosinase-related protein 1 increases expression ISO 3-methylquercetin results in increased expression of TYRP1 protein CTD PMID:24853321 NCBI chr 5:98,387,291...98,406,083
Ensembl chr 5:98,387,291...98,406,083 		JBrowse link
jaceosidin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO jaceosidin results in increased expression of and results in increased activity of BAX protein CTD PMID:27729209 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Casp3 caspase 3 increases activity ISO jaceosidin results in increased activity of CASP3 protein CTD PMID:27729209 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cflar CASP8 and FADD-like apoptosis regulator decreases expression
multiple interactions		 ISO jaceosidin results in decreased expression of CFLAR mRNA; jaceosidin results in decreased expression of CFLAR protein
CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]		 CTD PMID:27729209 NCBI chr 9:65,534,608...65,586,395
Ensembl chr 9:65,534,704...65,587,251 		JBrowse link
G Mcl1 MCL1 apoptosis regulator, BCL2 family member decreases expression
multiple interactions		 ISO jaceosidin results in decreased expression of MCL1 mRNA; jaceosidin results in decreased expression of MCL1 protein
MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein]		 CTD PMID:27729209 NCBI chr 2:197,786,212...197,788,992 JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases cleavage
multiple interactions		 ISO jaceosidin results in increased cleavage of PARP1 protein
benzyloxycarbonyl-valyl-alanyl-aspartic acid analog inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; CFLAR protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]; MCL1 protein inhibits the reaction [jaceosidin results in increased cleavage of PARP1 protein]		 CTD PMID:27729209 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO RELA protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; RELA protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Sp1 Sp1 transcription factor multiple interactions ISO SP1 protein inhibits the reaction [jaceosidin results in decreased expression of CFLAR protein]; SP1 protein inhibits the reaction [jaceosidin results in decreased expression of MCL1 protein] CTD PMID:27729209 NCBI chr 7:144,014,173...144,044,635
Ensembl chr 7:144,014,173...144,044,629 		JBrowse link
kaempferide term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Slc2a1 solute carrier family 2 member 1 decreases expression ISO kaempferide results in decreased expression of SLC2A1 mRNA CTD PMID:21865046 NCBI chr 5:138,154,677...138,182,897
Ensembl chr 5:138,154,673...138,182,897 		JBrowse link
G Vegfa vascular endothelial growth factor A increases expression ISO kaempferide results in increased expression of VEGFA mRNA CTD PMID:21865046 NCBI chr 9:17,340,341...17,355,681
Ensembl chr 9:17,340,341...17,355,681 		JBrowse link
nevadensin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Ache acetylcholinesterase multiple interactions
increases activity		 EXP 4-(6-bromo-1,3-benzodioxol-5-yl)-3a,4,5,9b-3H-cyclopenta(c)quinoline inhibits the reaction [nevadensin results in increased activity of ACHE protein] CTD PMID:31034797 NCBI chr12:22,472,358...22,477,052
Ensembl chr12:22,472,358...22,478,753 		JBrowse link
nobiletin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions ISO nobiletin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; nobiletin promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCB1 protein results in increased import of Daunorubicin] CTD PMID:18955043 PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcc1 ATP binding cassette subfamily C member 1 multiple interactions ISO nobiletin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate]; nobiletin promotes the reaction [ABCC1 protein results in increased import of fluorexon] CTD PMID:18955043 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 multiple interactions ISO [nobiletin co-treated with Hydrogen Peroxide] results in increased phosphorylation of AKT1 protein CTD PMID:29687528 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Asns asparagine synthetase (glutamine-hydrolyzing) increases expression ISO
EXP		 nobiletin results in increased expression of ASNS mRNA; nobiletin results in increased expression of ASNS protein CTD PMID:23321314 NCBI chr 4:33,742,876...33,761,106
Ensembl chr 4:33,743,364...33,761,163 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions ISO nobiletin inhibits the reaction [Hydrogen Peroxide results in increased expression of BAX protein] CTD PMID:29687528 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions ISO nobiletin inhibits the reaction [Hydrogen Peroxide results in decreased expression of BCL2 protein] CTD PMID:29687528 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO
EXP		 nobiletin results in decreased expression of CCNA2 mRNA CTD PMID:23321314 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccne2 cyclin E2 decreases expression ISO
EXP		 nobiletin results in decreased expression of CCNE2 mRNA CTD PMID:23321314 NCBI chr 5:24,434,077...24,446,406
Ensembl chr 5:24,434,872...24,446,406 		JBrowse link
G Cd74 CD74 molecule decreases expression ISO nobiletin results in decreased expression of CD74 mRNA CTD PMID:18818744 NCBI chr18:56,071,420...56,080,851
Ensembl chr18:56,071,478...56,080,849 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing
increases expression
multiple interactions		 ISO CYP1A1 protein results in increased metabolism of nobiletin
nobiletin results in increased expression of CYP1A1 protein
nobiletin inhibits the reaction [DDT results in increased expression of CYP1A1 mRNA]; nobiletin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]		 CTD PMID:20865247 PMID:22743247 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of nobiletin CTD PMID:22743247 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases expression ISO nobiletin results in increased expression of CYP1B1 mRNA CTD PMID:22743247 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 multiple interactions
increases activity		 ISO [[nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [nobiletin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam CTD PMID:31756459 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Ddit3 DNA-damage inducible transcript 3 increases expression ISO
EXP		 nobiletin results in increased expression of DDIT3 mRNA; nobiletin results in increased expression of DDIT3 protein CTD PMID:23321314 NCBI chr 7:70,578,564...70,585,074
Ensembl chr 7:70,580,198...70,585,084 		JBrowse link
G Depdc1 DEP domain containing 1 decreases expression ISO
EXP		 nobiletin results in decreased expression of DEPDC1 mRNA CTD PMID:23321314 NCBI chr 2:264,704,738...264,738,265
Ensembl chr 2:264,704,769...264,738,257 		JBrowse link
G E2f8 E2F transcription factor 8 decreases expression ISO
EXP		 nobiletin results in decreased expression of E2F8 mRNA CTD PMID:23321314 NCBI chr 1:104,185,436...104,203,683
Ensembl chr 1:104,187,100...104,202,591 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit increases expression EXP nobiletin results in increased expression of FOS mRNA CTD PMID:24964900 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of GPT protein] CTD PMID:31777137 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 increases expression EXP nobiletin results in increased expression of GRIN1 mRNA CTD PMID:24964900 NCBI chr 3:2,507,745...2,534,664
Ensembl chr 3:2,506,896...2,534,663 		JBrowse link
G Grin2a glutamate ionotropic receptor NMDA type subunit 2A increases expression EXP nobiletin results in increased expression of GRIN2A mRNA CTD PMID:24964900 NCBI chr10:5,707,806...6,123,568
Ensembl chr10:5,930,298...6,119,990 		JBrowse link
G Grin2b glutamate ionotropic receptor NMDA type subunit 2B increases expression EXP nobiletin results in increased expression of GRIN2B mRNA CTD PMID:24964900 NCBI chr 4:169,541,620...170,000,216
Ensembl chr 4:169,560,387...169,999,873 		JBrowse link
G H1f5 H1.5 linker histone, cluster member decreases expression ISO
EXP		 nobiletin results in decreased expression of H1-5 mRNA
nobiletin results in decreased expression of H1F5 mRNA		 CTD PMID:23321314 NCBI chr17:44,766,313...44,766,981
Ensembl chr17:44,766,313...44,766,981 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in decreased expression of HMOX1 protein] CTD PMID:31777137 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL1B protein] CTD PMID:31777137 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of IL6 protein] CTD PMID:31777137 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Kif11 kinesin family member 11 decreases expression ISO
EXP		 nobiletin results in decreased expression of KIF11 mRNA CTD PMID:23321314 NCBI chr 1:256,035,866...256,088,299
Ensembl chr 1:256,035,866...256,088,299 		JBrowse link
G Mmp7 matrix metallopeptidase 7 decreases expression ISO nobiletin results in decreased expression of MMP7 mRNA; nobiletin results in decreased expression of MMP7 protein CTD PMID:15725655 NCBI chr 8:5,893,253...5,900,965
Ensembl chr 8:5,893,249...5,901,049 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in decreased expression of NFE2L2 protein] CTD PMID:31777137 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Slc6a9 solute carrier family 6 member 9 increases expression ISO
EXP		 nobiletin results in increased expression of SLC6A9 mRNA CTD PMID:23321314 NCBI chr 5:136,669,674...136,703,702
Ensembl chr 5:136,669,674...136,703,697 		JBrowse link
G Tmem116 transmembrane protein 116 increases expression ISO
EXP		 nobiletin results in increased expression of TMEM116 mRNA CTD PMID:23321314 NCBI chr12:40,537,261...40,618,805
Ensembl chr12:40,557,677...40,590,361 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP nobiletin inhibits the reaction [Acetaminophen results in increased expression of TNF protein] CTD PMID:31777137 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Trib3 tribbles pseudokinase 3 increases expression ISO
EXP		 nobiletin results in increased expression of TRIB3 mRNA CTD PMID:23321314 NCBI chr 3:147,814,056...147,819,650
Ensembl chr 3:147,813,473...147,819,571 		JBrowse link
G Txnip thioredoxin interacting protein decreases expression ISO
EXP		 nobiletin results in decreased expression of TXNIP mRNA; nobiletin results in decreased expression of TXNIP protein CTD PMID:23321314 NCBI chr 2:198,683,168...198,686,971
Ensembl chr 2:198,683,159...198,686,974 		JBrowse link
oroxylin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity
multiple interactions		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein; diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA]		 CTD PMID:23470866 PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCG2 protein		 CTD PMID:32305507 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of BCL2 protein CTD PMID:19135124 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP3 protein CTD PMID:19135124 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 increases cleavage ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein CTD PMID:19135124 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Casp9 caspase 9 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP9 protein CTD PMID:19135124 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL2 protein] CTD PMID:32464219 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870 		JBrowse link
G Cdh5 cadherin 5 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of CDH5 protein] CTD PMID:32464219 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365 		JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form
diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form]		 CTD PMID:23470866 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624 		JBrowse link
G Ece1 endothelin converting enzyme 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein] CTD PMID:26694894 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671 		JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]] CTD PMID:26694894 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324 		JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]] CTD PMID:29476730 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901 		JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of FOS protein CTD PMID:22245252 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299 		JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]] CTD PMID:29476730 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of CXCL15 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of and affects the localization of HIF1A protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]		 CTD PMID:29476730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] CTD PMID:32464219 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with endotoxin, Escherichia coli] results in increased expression of IL10 protein CTD PMID:32464219 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL1B protein]		 CTD PMID:22101131 PMID:23236370 PMID:32464219 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]		 CTD PMID:22101131 PMID:23236370 PMID:29476730 PMID:32464219 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IRAK4 protein] CTD PMID:32464219 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK1 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]		 CTD PMID:22245252 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK3 protein		 CTD PMID:22245252 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 protein CTD PMID:22245252 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]		 CTD PMID:22245252 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22101131 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22101131 PMID:23236370 PMID:26694894 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein CTD PMID:19135124 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716 		JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]] CTD PMID:29476730 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752 		JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] CTD PMID:22245252 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22101131 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]		 CTD PMID:22101131 PMID:26694894 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein] CTD PMID:26694894 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167 		JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein] CTD PMID:26694894 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908 		JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]] CTD PMID:29476730 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Ethanol] results in decreased expression of SCD protein CTD PMID:29476730 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
multiple interactions		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A6 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]		 CTD PMID:32305507 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity		 ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A8 protein		 CTD PMID:32159797 PMID:32305507 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake ISO SLCO1B3 protein results in increased uptake of 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one CTD PMID:32305507 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] CTD PMID:29476730 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009 		JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:23236370 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533 		JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein CTD PMID:22245252 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072 		JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of TJP1 protein] CTD PMID:32464219 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]		 CTD PMID:22101131 PMID:29476730 PMID:32464219 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression		 ISO diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TP53 protein modified form] CTD PMID:23470866 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of VCAM1 protein] CTD PMID:32464219 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619 		JBrowse link
pedalitin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 decreases activity ISO pedalitin results in decreased activity of CYP1A2 protein CTD PMID:29753067 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp2c6v1 cytochrome P450, family 2, subfamily C, polypeptide 6, variant 1 decreases activity ISO pedalitin results in decreased activity of CYP2C19 protein CTD PMID:29753067 NCBI chr 1:147,713,879...147,814,410
Ensembl chr 1:147,713,892...147,888,007 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 decreases activity ISO pedalitin results in decreased activity of CYP3A4 protein CTD PMID:29753067 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
sciadopitysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO sciadopitysin results in decreased activity of ABCB1 protein
sciadopitysin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]		 CTD PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Bglap bone gamma-carboxyglutamate protein increases expression
multiple interactions		 ISO sciadopitysin results in increased expression of BGLAP protein
sciadopitysin inhibits the reaction [Antimycin A results in increased expression of BGLAP protein]		 CTD PMID:23624148 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO sciadopitysin inhibits the reaction [Antimycin A results in increased expression of TNF protein] CTD PMID:23624148 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
scullcapflavone II term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Casp3 caspase 3 affects binding ISO skullcapflavone II binds to CASP3 protein CTD PMID:32913905 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Mapk14 mitogen activated protein kinase 14 affects binding ISO skullcapflavone II binds to MAPK14 protein CTD PMID:32913905 NCBI chr20:5,933,290...5,995,137
Ensembl chr20:5,933,303...5,995,137 		JBrowse link
sinensetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A multiple interactions
decreases activity		 ISO sinensetin analog inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; sinensetin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]
sinensetin analog results in decreased activity of ABCB1 protein; sinensetin results in decreased activity of ABCB1 protein		 CTD PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 increases metabolic processing ISO CYP1A1 protein results in increased metabolism of sinensetin CTD PMID:19666078 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases metabolic processing ISO CYP1A2 protein results in increased metabolism of sinensetin CTD PMID:19666078 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing ISO CYP1B1 protein results in increased metabolism of sinensetin CTD PMID:19666078 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity
multiple interactions		 ISO sinensetin analog results in increased activity of CYP3A4 protein; sinensetin results in increased activity of CYP3A4 protein
[[sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [[sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [sinensetin analog results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam; [sinensetin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam		 CTD PMID:31756459 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity		 EXP [sinensetin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan CTD PMID:32259555 NCBI chr 4:176,158,174...176,231,331
Ensembl chr 4:176,158,640...176,231,344 		JBrowse link
tamarixetin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A increases expression ISO tamarixetin results in increased expression of ABCB1 mRNA CTD PMID:26238175 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO tamarixetin inhibits the reaction [Tetrachlorodibenzodioxin results in increased activity of AHR protein] CTD PMID:17090139 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 decreases phosphorylation ISO tamarixetin results in decreased phosphorylation of AKT1 protein CTD PMID:12826665 NCBI chr 6:137,218,398...137,239,970
Ensembl chr 6:137,218,376...137,236,258 		JBrowse link
G Casp3 caspase 3 increases activity ISO tamarixetin results in increased activity of CASP3 protein CTD PMID:12826665 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 increases expression ISO tamarixetin results in increased expression of CYP1A2 mRNA CTD PMID:19034627 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases expression ISO tamarixetin results in increased expression of CYP3A4 mRNA CTD PMID:26238175 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Cyp3a9 cytochrome P450, family 3, subfamily a, polypeptide 9 increases expression ISO tamarixetin results in increased expression of CYP3A5 mRNA CTD PMID:26238175 NCBI chr12:19,074,288...19,114,491
Ensembl chr12:19,074,583...19,114,399 		JBrowse link
G Nr1i2 nuclear receptor subfamily 1, group I, member 2 multiple interactions
increases activity		 ISO tamarixetin binds to and results in increased activity of NR1I2 protein
tamarixetin results in increased activity of NR1I2 protein		 CTD PMID:26238175 NCBI chr11:65,022,100...65,058,546
Ensembl chr11:65,022,100...65,058,545 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 decreases activity ISO tamarixetin results in decreased activity of PTGS2 protein CTD PMID:15292928 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
tangeretin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases activity
multiple interactions		 ISO tangeretin results in decreased activity of ABCB1 protein
tangeretin inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]		 CTD PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515 		JBrowse link
G Agtr1b angiotensin II receptor, type 1b multiple interactions EXP tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of AGTR1B protein] CTD PMID:32479886 NCBI chr 2:105,149,020...105,224,335
Ensembl chr 2:105,149,020...105,224,295 		JBrowse link
G Casp3 caspase 3 multiple interactions EXP tangeretin inhibits the reaction [Cisplatin results in increased expression of CASP3 protein] CTD PMID:27616468 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Cat catalase multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of CAT protein] CTD PMID:24995432 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cyb5a cytochrome b5 type A multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of CYB5A protein] CTD PMID:24995432 NCBI chr18:81,694,818...81,726,821
Ensembl chr18:81,694,808...81,726,821 		JBrowse link
G Cybb cytochrome b-245 beta chain multiple interactions EXP tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in increased expression of CYBB protein] CTD PMID:32479886 NCBI chr  X:14,578,330...14,610,049
Ensembl chr  X:14,578,264...14,612,547 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
increases expression
increases metabolic processing		 ISO tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 protein]
tangeretin results in increased expression of CYP1A1 protein
CYP1A1 protein results in increased metabolism of tangeretin		 CTD PMID:17090139 PMID:29626627 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions
increases metabolic processing		 ISO tangeretin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A2 mRNA]
CYP1A2 protein results in increased metabolism of tangeretin		 CTD PMID:17090139 PMID:29626627 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301 		JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 increases metabolic processing
increases expression		 ISO CYP1B1 protein results in increased metabolism of tangeretin
tangeretin results in increased expression of CYP1B1 protein		 CTD PMID:29626627 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722 		JBrowse link
G Cyp3a62 cytochrome P450, family 3, subfamily a, polypeptide 62 increases activity
multiple interactions		 ISO tangeretin results in increased activity of CYP3A4 protein
[[tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam] which results in increased chemical synthesis of 1-hydroxymethylmidazolam; [tangeretin results in increased activity of CYP3A4 protein] which results in increased metabolism of Midazolam		 CTD PMID:31756459 NCBI chr12:18,679,809...18,709,397
Ensembl chr12:18,678,594...18,709,397 		JBrowse link
G Gsr glutathione-disulfide reductase multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased activity of GSR protein] CTD PMID:24995432 NCBI chr16:62,197,617...62,239,987
Ensembl chr16:62,197,617...62,241,361 		JBrowse link
G Hmox1 heme oxygenase 1 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HMOX1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of HMOX1 protein] CTD PMID:24995432 NCBI chr19:14,508,634...14,515,455
Ensembl chr19:14,508,616...14,515,456 		JBrowse link
G Il10 interleukin 10 multiple interactions EXP tangeretin inhibits the reaction [Cisplatin results in decreased expression of IL10 protein] CTD PMID:27616468 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392 		JBrowse link
G Il1b interleukin 1 beta multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL1B protein] CTD PMID:24995432 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of IL6 protein] CTD PMID:24995432 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Keap1 Kelch-like ECH-associated protein 1 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of KEAP1 protein] CTD PMID:24995432 NCBI chr 8:22,250,518...22,259,868
Ensembl chr 8:22,250,518...22,259,779 		JBrowse link
G Nfe2l2 nuclear factor, erythroid 2-like 2 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NFE2L2 protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of NFE2L2 protein] CTD PMID:24995432 PMID:27616468 NCBI chr 3:62,497,568...62,525,146
Ensembl chr 3:62,497,571...62,524,996 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of NOS2 protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of NOS2 protein] CTD PMID:24995432 PMID:27616468 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Nos3 nitric oxide synthase 3 multiple interactions EXP tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of NOS3 protein] CTD PMID:32479886 NCBI chr 4:7,321,908...7,342,404
Ensembl chr 4:7,320,668...7,342,410 		JBrowse link
G Nqo1 NAD(P)H quinone dehydrogenase 1 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NQO1 mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in decreased expression of NQO1 protein] CTD PMID:24995432 NCBI chr19:38,422,210...38,437,103
Ensembl chr19:38,422,164...38,437,180 		JBrowse link
G Pkm pyruvate kinase M1/2 increases activity ISO tangeretin results in increased activity of PKM protein CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of PTGS2 protein] CTD PMID:24995432 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RELA mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of RELA protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of RELA protein] CTD PMID:24995432 PMID:27616468 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Star steroidogenic acute regulatory protein multiple interactions EXP tangeretin inhibits the reaction [NG-Nitroarginine Methyl Ester results in decreased expression of STAR protein] CTD PMID:32479886 NCBI chr16:71,036,204...71,040,847
Ensembl chr16:71,036,204...71,040,847 		JBrowse link
G Tnf tumor necrosis factor multiple interactions EXP tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF mRNA]; tangeretin inhibits the reaction [9,10-Dimethyl-1,2-benzanthracene results in increased expression of TNF protein]; tangeretin inhibits the reaction [Cisplatin results in increased expression of TNF protein] CTD PMID:24995432 PMID:27616468 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
tectochrysin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcg2 ATP binding cassette subfamily G member 2 decreases activity ISO tectochrysin results in decreased activity of ABCG2 protein CTD PMID:15930306 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621 		JBrowse link
wogonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein] CTD PMID:23246481 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [wogonin co-treated with Fluorouracil] results in increased expression of BAX protein
wogonin results in increased expression of BAX protein		 CTD PMID:20570612 PMID:21457722 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein
wogonin results in decreased expression of BCL2 protein		 CTD PMID:20570612 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 wogonin results in increased activity of CASP3 protein
wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein]
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein]
[wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein		 CTD PMID:20570612 PMID:26756871 PMID:31103702 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] CTD PMID:26756871 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein]
wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]		 CTD PMID:26213241 PMID:31103702 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO wogonin results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP		 wogonin results in decreased expression of CCND1 protein CTD PMID:21457722 PMID:23872260 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO
EXP		 wogonin results in decreased expression of CDK2 protein CTD PMID:23872260 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO
EXP		 wogonin results in decreased expression of CDK4 protein CTD PMID:23872260 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein CTD PMID:32671444 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO
EXP		 wogonin results in increased expression of CDKN1B protein CTD PMID:23872260 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein CTD PMID:32671444 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
increases expression		 ISO
EXP		 wogonin results in decreased expression of CTNNB1 protein
Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein]
wogonin results in increased expression of CTNNB1 protein modified form		 CTD PMID:23872260 PMID:31103702 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
wogonin results in decreased expression of CYP1A1 mRNA		 CTD PMID:18451504 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO wogonin results in decreased expression of DPYD mRNA CTD PMID:20570612 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO
EXP		 Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein] CTD PMID:23872260 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO wogonin results in increased expression of GLB1 protein CTD PMID:32671444 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases expression		 ISO
EXP		 wogonin results in decreased expression of GSK3B protein modified form
wogonin results in increased expression of GSK3B protein		 CTD PMID:23872260 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein] CTD PMID:26213241 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Ifng interferon gamma multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]		 CTD PMID:26213241 PMID:31103702 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion		 ISO wogonin results in increased expression of IL6 protein
wogonin results in increased secretion of IL6 protein
wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein		 CTD PMID:32671444 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] CTD PMID:17570322 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] CTD PMID:23362215 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
wogonin results in decreased phosphorylation of MAPK1 protein		 CTD PMID:21295103 PMID:23362215 PMID:26892447 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
wogonin results in decreased phosphorylation of MAPK3 protein		 CTD PMID:21295103 PMID:23362215 PMID:26892447 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:23362215 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:23362215 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO wogonin results in decreased expression of MKI67 protein CTD PMID:32671444 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO wogonin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:21295103 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein]
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein		 CTD PMID:14700523 PMID:21295103