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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:oroxylin A
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Accession:CHEBI:61668 term browser browse the term
Definition:A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-6.
Synonyms:exact_synonym: 5,7-dihydroxy-6-methoxy-2-phenyl-4H-chromen-4-one
 related_synonym: 5,7-dihydroxy-6-methoxy-2-phenyl-4H-1-benzopyran-4-one;   5,7-dihydroxy-6-methoxyflavone;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-16-11(18)8-13-14(15(16)19)10(17)7-12(21-13)9-5-3-2-4-6-9/h2-8,18-19H,1H3;   InChIKey=LKOJGSWUMISDOF-UHFFFAOYSA-N;   SMILES=COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccccc1;   baicalein 6-methyl ether
 xref: CAS:480-11-5;   LIPID_MAPS_instance:LMPK12111096
 xref_mesh: MESH:C080669
 xref: MetaCyc:CPD-12734;   PMID:12818372;   PMID:22366656;   PMID:22560876;   PMID:23238475;   PMID:23371806;   Reaxys:281274;   Wikipedia:Oroxylin_A
 cyclic_relationship: is_conjugate_acid_of CHEBI:77939


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oroxylin A term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcb1a ATP binding cassette subfamily B member 1A decreases expression
decreases activity
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCB1 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCB1 protein results in increased transport of Digoxin]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of and results in decreased activity of ABCB1 protein; diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of ABCB1 mRNA]
CTD PMID:23470866, PMID:30790579 NCBI chr 4:22,339,829...22,517,642
Ensembl chr 4:22,133,521...22,425,515
JBrowse link
G Abcg2 ATP binding cassette subfamily G member 2 multiple interactions
decreases activity
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [ABCG2 protein results in increased uptake of lucifer yellow]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of ABCG2 protein
CTD PMID:32305507 NCBI chr 4:88,765,441...88,890,268
Ensembl chr 4:88,832,178...88,890,621
JBrowse link
G Bcl2 BCL2, apoptosis regulator decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of BCL2 protein CTD PMID:19135124 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374
JBrowse link
G Casp3 caspase 3 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP3 protein CTD PMID:19135124 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204
JBrowse link
G Casp8 caspase 8 increases cleavage ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased cleavage of CASP8 protein CTD PMID:19135124 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106
JBrowse link
G Casp9 caspase 9 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of CASP9 protein CTD PMID:19135124 NCBI chr 5:160,356,211...160,373,774
Ensembl chr 5:160,355,833...160,373,778
JBrowse link
G Ccl2 C-C motif chemokine ligand 2 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of CCL2 protein] CTD PMID:32464219 NCBI chr10:69,412,065...69,413,863
Ensembl chr10:69,412,017...69,413,870
JBrowse link
G Cdh5 cadherin 5 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of CDH5 protein] CTD PMID:32464219 NCBI chr19:1,025,122...1,074,333
Ensembl chr19:1,023,683...1,074,365
JBrowse link
G Chek2 checkpoint kinase 2 increases expression
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form
diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of CHEK2 protein modified form]
CTD PMID:23470866 NCBI chr12:51,845,574...51,878,098
Ensembl chr12:51,845,796...51,877,624
JBrowse link
G Ece1 endothelin converting enzyme 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of ECE1 protein] CTD PMID:26694894 NCBI chr 5:156,215,469...156,318,652
Ensembl chr 5:156,215,417...156,318,671
JBrowse link
G Edn1 endothelin 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of and results in increased secretion of EDN1 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 mRNA]; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one promotes the reaction [Lipopolysaccharides results in increased expression of EDN1 protein]] CTD PMID:26694894 NCBI chr17:22,136,814...22,143,745
Ensembl chr17:22,137,324...22,143,324
JBrowse link
G Fasn fatty acid synthase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]] CTD PMID:29476730 NCBI chr10:109,987,735...110,005,901
Ensembl chr10:109,987,735...110,005,901
JBrowse link
G Fos Fos proto-oncogene, AP-1 transcription factor subunit decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of FOS protein CTD PMID:22245252 NCBI chr 6:109,300,433...109,303,299
Ensembl chr 6:109,300,433...109,303,299
JBrowse link
G Gpt glutamic--pyruvic transaminase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]] CTD PMID:29476730 NCBI chr 7:117,759,083...117,761,932
Ensembl chr 7:117,759,083...117,761,931
JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased activity of GPT protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of CXCL15 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of and affects the localization of HIF1A protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of FASN protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]]
CTD PMID:29476730 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052
JBrowse link
G Hmgb1 high mobility group box 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of HMGB1 protein] CTD PMID:32464219 NCBI chr12:7,082,529...7,090,246
Ensembl chr16:37,500,017...37,502,237
JBrowse link
G Il10 interleukin 10 multiple interactions EXP [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with endotoxin, Escherichia coli] results in increased expression of IL10 protein CTD PMID:32464219 NCBI chr13:47,738,933...47,743,392
Ensembl chr13:47,739,526...47,743,392
JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL1B protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL1B mRNA]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL1B protein]
CTD PMID:22101131, PMID:23236370, PMID:32464219 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726
JBrowse link
G Il6 interleukin 6 multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 mRNA]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of IL6 protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IL6 protein]
CTD PMID:22101131, PMID:23236370, PMID:29476730, PMID:32464219 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Irak4 interleukin-1 receptor-associated kinase 4 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of IRAK4 protein] CTD PMID:32464219 NCBI chr 7:135,803,723...135,831,006
Ensembl chr 7:135,803,698...135,832,652
JBrowse link
G Mapk1 mitogen activated protein kinase 1 decreases phosphorylation
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK1 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
CTD PMID:22245252 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254
JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased phosphorylation of MAPK3 protein
CTD PMID:22245252 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975
JBrowse link
G Mmp2 matrix metallopeptidase 2 decreases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP2 protein CTD PMID:22245252 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611
JBrowse link
G Mmp9 matrix metallopeptidase 9 decreases expression
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 mRNA; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased expression of MMP9 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]
CTD PMID:22245252 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520
JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of and results in increased degradation of NFKBIA protein] CTD PMID:22101131 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457
JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of NOS2 protein] which results in increased abundance of Nitric Oxide]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of NOS2 protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein] CTD PMID:22101131, PMID:23236370, PMID:26694894 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190
JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 increases degradation ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased degradation of PARP1 protein CTD PMID:19135124 NCBI chr13:98,857,255...98,889,444
Ensembl chr13:98,857,177...98,889,716
JBrowse link
G Ppara peroxisome proliferator activated receptor alpha multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in decreased expression of PPARA protein]] CTD PMID:29476730 NCBI chr 7:126,618,872...126,687,282
Ensembl chr 7:126,619,196...126,681,752
JBrowse link
G Prkcd protein kinase C, delta multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Tetradecanoylphorbol Acetate affects the localization of PRKCD protein] CTD PMID:22245252 NCBI chr16:6,655,131...6,675,746
Ensembl chr16:6,655,120...6,675,746
JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [[Lipopolysaccharides results in increased expression of PTGS2 protein] which results in increased abundance of Dinoprostone]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of PTGS2 protein] CTD PMID:22101131 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335
JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased localization of RELA protein]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of RELA protein]
CTD PMID:22101131, PMID:26694894 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249
JBrowse link
G Rhoa ras homolog family member A multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in decreased expression of and results in decreased activity of RHOA protein] CTD PMID:26694894 NCBI chr 8:117,082,440...117,116,244
Ensembl chr 8:117,106,576...117,116,167
JBrowse link
G Rock2 Rho-associated coiled-coil containing protein kinase 2 multiple interactions EXP [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein; [cyclo(Trp-Asp-Pro-Val-Leu) co-treated with BQ 788] inhibits the reaction [[5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Lipopolysaccharides] results in increased phosphorylation of ROCK2 protein] CTD PMID:26694894 NCBI chr 6:42,180,864...42,289,910
Ensembl chr 6:42,180,894...42,289,908
JBrowse link
G Scd stearoyl-CoA desaturase multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SCD protein]] CTD PMID:29476730 NCBI chr 1:264,159,966...264,173,061
Ensembl chr 1:264,160,129...264,172,729
JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 multiple interactions ISO [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one co-treated with Ethanol] results in decreased expression of SCD protein CTD PMID:29476730 NCBI chr 1:264,059,374...264,072,433
Ensembl chr 1:264,059,374...264,072,433
JBrowse link
G Slc22a6 solute carrier family 22 member 6 decreases activity
multiple interactions
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A6 protein
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A6 protein results in increased uptake of p-Aminohippuric Acid]
CTD PMID:32305507 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259
JBrowse link
G Slc22a8 solute carrier family 22 member 8 multiple interactions
decreases activity
ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [SLC22A8 protein results in increased uptake of estrone sulfate]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in decreased activity of SLC22A8 protein
CTD PMID:32159797, PMID:32305507 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482
JBrowse link
G Slco1b2 solute carrier organic anion transporter family member 1B2 increases uptake ISO SLCO1B3 protein results in increased uptake of 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one CTD PMID:32305507 NCBI chr 4:175,814,118...175,881,775
Ensembl chr 4:175,814,118...175,881,768
JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of SREBF1 protein]] CTD PMID:29476730 NCBI chr10:46,570,996...46,593,021
Ensembl chr10:46,570,996...46,593,009
JBrowse link
G Stat1 signal transducer and activator of transcription 1 multiple interactions ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of STAT1 protein] CTD PMID:23236370 NCBI chr 9:54,287,540...54,327,958
Ensembl chr 9:54,287,541...54,484,533
JBrowse link
G Timp2 TIMP metallopeptidase inhibitor 2 increases expression ISO 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TIMP2 protein CTD PMID:22245252 NCBI chr10:107,338,465...107,386,072
Ensembl chr10:107,338,465...107,386,072
JBrowse link
G Tjp1 tight junction protein 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in decreased expression of TJP1 protein] CTD PMID:32464219 NCBI chr 1:126,146,489...126,515,359
Ensembl chr 1:126,146,489...126,227,469
JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased expression of TNF mRNA]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one analog inhibits the reaction [Lipopolysaccharides results in increased secretion of TNF protein]; 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]; HIF1A protein inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [Ethanol results in increased expression of TNF protein]]
5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of TNF protein]
CTD PMID:22101131, PMID:29476730, PMID:32464219 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000
JBrowse link
G Tp53 tumor protein p53 multiple interactions
increases expression
ISO diacetyldiphenylurea bisguanylhydrazone inhibits the reaction [5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one results in increased expression of TP53 protein modified form] CTD PMID:23470866 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449
JBrowse link
G Vcam1 vascular cell adhesion molecule 1 multiple interactions EXP 5,7-dihydroxy-6-methoxy-2-phenylchromen-4-one inhibits the reaction [endotoxin, Escherichia coli results in increased expression of VCAM1 protein] CTD PMID:32464219 NCBI chr 2:219,071,193...219,090,931
Ensembl chr 2:219,071,193...219,097,619
JBrowse link

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  CHEBI ontology 19816
    role 19764
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              oroxylin A 45
                oroxylin A 7-O-beta-D-glucuronide 0
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  CHEBI ontology 19816
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                  main group element atom 19702
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                        carbon atom 19597
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                            organic molecule 19522
                              organic cyclic compound 19320
                                organic heterocyclic compound 18432
                                  oxacycle 17200
                                    benzopyran 10142
                                      1-benzopyran 9858
                                        flavonoid 6376
                                          flavones 4169
                                            methoxyflavone 416
                                              monomethoxyflavone 138
                                                oroxylin A 45
                                                  oroxylin A 7-O-beta-D-glucuronide 0
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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.