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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:hispidulin
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Accession:CHEBI:75902 term browser browse the term
Definition:A monomethoxyflavone that is scutellarein methylated at position 6.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-hydroxyphenyl)-6-methoxy-4H-chromen-4-one
 related_synonym: 4',5,7-Trihydroxy-6-methoxyflavone;   Dinatin;   Formula=C16H12O6;   InChI=1S/C16H12O6/c1-21-16-11(19)7-13-14(15(16)20)10(18)6-12(22-13)8-2-4-9(17)5-3-8/h2-7,17,19-20H,1H3;   InChIKey=IHFBPDAQLQOCBX-UHFFFAOYSA-N;   NSC 122415;   SMILES=COc1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1;   Scutellarein 6-methyl ether
 alt_id: CHEBI:5732
 xref: CAS:1447-88-7;   KEGG:C10058;   KNApSAcK:C00001050;   LIPID_MAPS_instance:LMPK12111159
 xref_mesh: MESH:C055957
 xref: PMID:11585687;   PMID:20117183;   PMID:20698539;   PMID:20734985;   PMID:20738216;   PMID:21087351;   PMID:21162116;   PMID:21329950;   PMID:21552369;   PMID:22418930;   PMID:22674731;   PMID:22759588;   PMID:22978216;   PMID:23189738;   PMID:23791609;   PMID:24009700;   PMID:24068521;   Reaxys:1293933;   Wikipedia:Hispidulin


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hispidulin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein] CTD PMID:30055130 NCBI chr11:77,721,912...77,735,644 JBrowse link
G Cebpa CCAAT/enhancer binding protein alpha multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA] CTD PMID:30055130 NCBI chr 1:87,759,631...87,762,303 JBrowse link
G Ins2 insulin 2 multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of ADIPOQ protein]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of CEBPA mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 1:197,843,277...197,992,522 JBrowse link
G Jak2 Janus kinase 2 decreases phosphorylation ISO hispidulin decreases phoshphorylation of JAK2 protein in colon and colorectum RGD PMID:29575334 RGD:149735333 NCBI chr 1:226,995,334...227,054,381 JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK1 protein] CTD PMID:22759588 NCBI chr11:83,957,813...84,023,629 JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions EXP hispidulin inhibits the reaction [4-Aminopyridine results in increased phosphorylation of MAPK3 protein] CTD PMID:22759588 NCBI chr 1:181,366,646...181,372,863 JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions ISO hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG mRNA]; hispidulin inhibits the reaction [[1-Methyl-3-isobutylxanthine co-treated with Dexamethasone co-treated with INS protein co-treated with Indomethacin] results in increased expression of PPARG protein] CTD PMID:30055130 NCBI chr 4:148,423,102...148,548,471 JBrowse link
G Slco1a1 solute carrier organic anion transporter family, member 1a1 multiple interactions
decreases activity
EXP [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Bosentan; [hispidulin results in decreased activity of SLCO1B1 protein] which results in decreased uptake of Methotrexate CTD PMID:32259555 NCBI chr 4:174,877,045...174,950,857 JBrowse link
G Syn1 synapsin I affects response to substance ISO SYN1 protein affects the susceptibility to hispidulin CTD PMID:22759588 NCBI chr  X:1,172,208...1,227,400 JBrowse link

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Path 1
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  CHEBI ontology 19762
    role 19708
      chemical role 19254
        antioxidant 14376
          hispidulin 9
Path 2
Term Annotations click to browse term
  CHEBI ontology 19762
    subatomic particle 19760
      composite particle 19760
        hadron 19760
          baryon 19760
            nucleon 19760
              atomic nucleus 19760
                atom 19760
                  main group element atom 19651
                    p-block element atom 19651
                      carbon group element atom 19570
                        carbon atom 19560
                          organic molecular entity 19560
                            organic molecule 19493
                              organic cyclic compound 19322
                                organic heterocyclic compound 18554
                                  oxacycle 17539
                                    benzopyran 10268
                                      1-benzopyran 9991
                                        flavonoid 6513
                                          flavones 4201
                                            hydroxyflavone 4189
                                              trihydroxyflavone 354
                                                apigenin 244
                                                  scutellarein 25
                                                    hispidulin 9
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