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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4',5,7-trihydroxy-3'-methoxyflavone
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Accession:CHEBI:16514 term browser browse the term
Definition:The 3'-O-methyl derivative of luteolin.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 3'-Methoxyapigenin;   3'-O-Methylluteolin;   5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone;   5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one;   Chryseriol;   Chrysoeriol;   Formula=C16H12O6;   InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3;   InChIKey=SCZVLDHREVKTSH-UHFFFAOYSA-N;   Luteolin 3'-methyl ether;   SMILES=COc1cc(ccc1O)-c1cc(=O)c2c(O)cc(O)cc2o1
 alt_id: CHEBI:12083;   CHEBI:2006;   CHEBI:20519
 xref: Beilstein:295004;   CAS:491-71-4;   KEGG:C04293;   KNApSAcK:C00001029;   LIPID_MAPS_instance:LMPK12110799
 xref_mesh: MESH:C007054
 xref: MetaCyc:574-TRIHYDROXY-3-METHOXYFLAVONE;   PMID:22438130;   PMID:22577954;   PMID:23017389;   PMID:23052184;   PMID:23122135;   Reaxys:295004
 cyclic_relationship: is_conjugate_acid_of CHEBI:57799



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4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19800
    role 19751
      chemical role 19320
        antioxidant 14438
          4',5,7-trihydroxy-3'-methoxyflavone 11
            6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol 0
            7-O-(6-p-coumaroylglucosyl)chrysoeriol 0
            7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol 0
            chrysoeriol 7-O-gentiobioside 0
            geraldone 0
            isoscoparin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19800
    subatomic particle 19799
      composite particle 19799
        hadron 19799
          baryon 19799
            nucleon 19799
              atomic nucleus 19799
                atom 19799
                  main group element atom 19698
                    p-block element atom 19698
                      carbon group element atom 19619
                        carbon atom 19609
                          organic molecular entity 19609
                            organic molecule 19549
                              organic cyclic compound 19343
                                organic heterocyclic compound 18584
                                  oxacycle 17609
                                    benzopyran 11162
                                      1-benzopyran 10903
                                        flavonoid 6523
                                          flavones 4210
                                            hydroxyflavone 4198
                                              3'-hydroxyflavonoid 260
                                                luteolin 203
                                                  4',5,7-trihydroxy-3'-methoxyflavone 11
                                                    6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol 0
                                                    7-O-(6-p-coumaroylglucosyl)chrysoeriol 0
                                                    7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol 0
                                                    chrysoeriol 7-O-gentiobioside 0
                                                    geraldone 0
                                                    isoscoparin + 0
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