4',5,7-trihydroxy-3'-methoxyflavone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4',5,7-trihydroxy-3'-methoxyflavone	go back to main search page
Accession:	CHEBI:16514	browse the term
Definition:	The 3'-O-methyl derivative of luteolin.
Synonyms:	exact_synonym:	5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
	related_synonym:	3'-Methoxyapigenin; 3'-O-Methylluteolin; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; Chryseriol; Chrysoeriol; Formula=C16H12O6; InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3; InChIKey=SCZVLDHREVKTSH-UHFFFAOYSA-N; Luteolin 3'-methyl ether; SMILES=COc1cc(ccc1O)-c1cc(=O)c2c(O)cc(O)cc2o1
	alt_id:	CHEBI:12083; CHEBI:2006; CHEBI:20519
	xref:	Beilstein:295004; CAS:491-71-4; KEGG:C04293; KNApSAcK:C00001029; LIPID_MAPS_instance:LMPK12110799
	xref_mesh:	MESH:C007054
	xref:	MetaCyc:574-TRIHYDROXY-3-METHOXYFLAVONE; PMID:22438130; PMID:22577954; PMID:23017389; PMID:23052184; PMID:23122135; Reaxys:295004
	cyclic_relationship:	is_conjugate_acid_of CHEBI:57799

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Genes (11)

4',5,7-trihydroxy-3'-methoxyflavone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

decreases activity

chrysoeriol results in decreased activity of ABCC1 protein

NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196

G

aryl hydrocarbon receptor

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein]

NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464

G

bone gamma-carboxyglutamate protein

multiple interactions

chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein]

NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]

NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]

NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]

NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722

G

interleukin 6

multiple interactions

chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]

NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807

G

melatonin receptor 1A

affects binding

chrysoeriol binds to MTNR1A protein

NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809

G

melatonin receptor 1B

affects binding

chrysoeriol binds to MTNR1B protein

NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894

G

N-ribosyldihydronicotinamide:quinone reductase 2

multiple interactions

chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]

NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538

G

TNF superfamily member 11

multiple interactions

chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]

NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19771
role	19716
chemical role	19256
antioxidant	14273
4',5,7-trihydroxy-3'-methoxyflavone	11
6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol	0
7-O-(6-p-coumaroylglucosyl)chrysoeriol	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol	0
chrysoeriol 7-O-gentiobioside	0
geraldone	0
isoscoparin +	0
Path 2
Term	Annotations
CHEBI ontology	19771
subatomic particle	19770
composite particle	19770
hadron	19770
baryon	19770
nucleon	19770
atomic nucleus	19770
atom	19770
main group element atom	19658
p-block element atom	19658
carbon group element atom	19574
carbon atom	19564
organic molecular entity	19564
organic molecule	19497
organic cyclic compound	19321
organic heterocyclic compound	18512
oxacycle	17548
benzopyran	10280
1-benzopyran	10002
flavonoid	6516
flavones	4200
hydroxyflavone	4188
3'-hydroxyflavonoid	241
luteolin	183
4',5,7-trihydroxy-3'-methoxyflavone	11
6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol	0
7-O-(6-p-coumaroylglucosyl)chrysoeriol	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol	0
chrysoeriol 7-O-gentiobioside	0
geraldone	0
isoscoparin +	0

paths to the root