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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:4',5,7-trihydroxy-3'-methoxyflavone
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Accession:CHEBI:16514 term browser browse the term
Definition:The 3'-O-methyl derivative of luteolin.
Synonyms:exact_synonym: 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
 related_synonym: 3'-Methoxyapigenin;   3'-O-Methylluteolin;   5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone;   5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one;   Chryseriol;   Chrysoeriol;   Formula=C16H12O6;   InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3;   InChIKey=SCZVLDHREVKTSH-UHFFFAOYSA-N;   Luteolin 3'-methyl ether;   SMILES=COc1cc(ccc1O)-c1cc(=O)c2c(O)cc(O)cc2o1
 alt_id: CHEBI:12083;   CHEBI:2006;   CHEBI:20519
 xref: Beilstein:295004;   CAS:491-71-4;   KEGG:C04293;   KNApSAcK:C00001029;   LIPID_MAPS_instance:LMPK12110799
 xref_mesh: MESH:C007054
 xref: MetaCyc:574-TRIHYDROXY-3-METHOXYFLAVONE;   PMID:22438130;   PMID:22577954;   PMID:23017389;   PMID:23052184;   PMID:23122135;   Reaxys:295004
 cyclic_relationship: is_conjugate_acid_of CHEBI:57799


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4',5,7-trihydroxy-3'-methoxyflavone term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abcc1 ATP binding cassette subfamily C member 1 decreases activity ISO chrysoeriol results in decreased activity of ABCC1 protein CTD PMID:15670588 NCBI chr10:549,537...672,235
Ensembl chr10:549,883...672,196
JBrowse link
G Ahr aryl hydrocarbon receptor multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein] CTD PMID:20553787 NCBI chr 6:54,963,990...55,001,806
Ensembl chr 6:54,963,990...55,001,464
JBrowse link
G Bglap bone gamma-carboxyglutamate protein multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein] CTD PMID:20981859 NCBI chr 2:187,741,770...187,748,445
Ensembl chr 2:187,741,770...187,742,747
JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA] CTD PMID:20553787 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147
JBrowse link
G Cyp1a2 cytochrome P450, family 1, subfamily a, polypeptide 2 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA] CTD PMID:20553787 NCBI chr 8:62,451,360...62,458,244
Ensembl chr 8:62,451,329...62,458,301
JBrowse link
G Cyp1b1 cytochrome P450, family 1, subfamily b, polypeptide 1 multiple interactions ISO chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA] CTD PMID:20553787 NCBI chr 6:2,308,179...2,316,739
Ensembl chr 6:2,307,808...2,316,722
JBrowse link
G Il6 interleukin 6 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein] CTD PMID:20981859 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807
JBrowse link
G Mtnr1a melatonin receptor 1A affects binding ISO chrysoeriol binds to MTNR1A protein CTD PMID:20399199 NCBI chr16:50,339,358...50,358,809
Ensembl chr16:50,339,358...50,358,809
JBrowse link
G Mtnr1b melatonin receptor 1B affects binding ISO chrysoeriol binds to MTNR1B protein CTD PMID:20399199 NCBI chr 8:14,359,270...14,373,894
Ensembl chr 8:14,359,270...14,373,894
JBrowse link
G Nqo2 N-ribosyldihydronicotinamide:quinone reductase 2 multiple interactions ISO chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3] CTD PMID:20399199 NCBI chr17:32,131,847...32,158,559
Ensembl chr17:32,132,347...32,158,538
JBrowse link
G Tnfsf11 TNF superfamily member 11 multiple interactions ISO chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein] CTD PMID:20981859 NCBI chr15:60,482,527...60,512,704
Ensembl chr15:60,482,527...60,512,704
JBrowse link

Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19771
    role 19716
      chemical role 19256
        antioxidant 14273
          4',5,7-trihydroxy-3'-methoxyflavone 11
            6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol 0
            7-O-(6-p-coumaroylglucosyl)chrysoeriol 0
            7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol 0
            chrysoeriol 7-O-gentiobioside 0
            geraldone 0
            isoscoparin + 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19771
    subatomic particle 19770
      composite particle 19770
        hadron 19770
          baryon 19770
            nucleon 19770
              atomic nucleus 19770
                atom 19770
                  main group element atom 19658
                    p-block element atom 19658
                      carbon group element atom 19574
                        carbon atom 19564
                          organic molecular entity 19564
                            organic molecule 19497
                              organic cyclic compound 19321
                                organic heterocyclic compound 18512
                                  oxacycle 17548
                                    benzopyran 10280
                                      1-benzopyran 10002
                                        flavonoid 6516
                                          flavones 4200
                                            hydroxyflavone 4188
                                              3'-hydroxyflavonoid 241
                                                luteolin 183
                                                  4',5,7-trihydroxy-3'-methoxyflavone 11
                                                    6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol 0
                                                    7-O-(6-p-coumaroylglucosyl)chrysoeriol 0
                                                    7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol 0
                                                    chrysoeriol 7-O-gentiobioside 0
                                                    geraldone 0
                                                    isoscoparin + 0
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