CHEBI ONTOLOGY - ANNOTATIONS
The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/ . The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/ ). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term: 4',5,7-trihydroxy-3'-methoxyflavone
Accession: CHEBI:16514
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Definition: The 3'-O-methyl derivative of luteolin.
Synonyms: exact_synonym: 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
related_synonym: 3'-Methoxyapigenin; 3'-O-Methylluteolin; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; Chryseriol; Chrysoeriol; Formula=C16H12O6; InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3; InChIKey=SCZVLDHREVKTSH-UHFFFAOYSA-N; Luteolin 3'-methyl ether; SMILES=COc1cc(ccc1O)-c1cc(=O)c2c(O)cc(O)cc2o1
alt_id: CHEBI:12083; CHEBI:2006; CHEBI:20519
xref: Beilstein:295004; CAS:491-71-4; KEGG:C04293; KNApSAcK:C00001029; LIPID_MAPS_instance:LMPK12110799
xref_mesh: MESH:C007054
xref: MetaCyc:574-TRIHYDROXY-3-METHOXYFLAVONE; PMID:22438130; PMID:22577954; PMID:23017389; PMID:23052184; PMID:23122135; Reaxys:295004
cyclic_relationship: is_conjugate_acid_of CHEBI:57799
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Abcc1
ATP binding cassette subfamily C member 1
decreases activity
ISO
chrysoeriol results in decreased activity of ABCC1 protein
CTD
PMID:15670588
NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114
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Ahr
aryl hydrocarbon receptor
multiple interactions
ISO
chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein]
CTD
PMID:20553787
NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568
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Bglap
bone gamma-carboxyglutamate protein
multiple interactions
ISO
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein]
CTD
PMID:20981859
NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495
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Cyp1a1
cytochrome P450, family 1, subfamily a, polypeptide 1
multiple interactions
ISO
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]
CTD
PMID:20553787
NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125
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Cyp1a2
cytochrome P450, family 1, subfamily a, polypeptide 2
multiple interactions
ISO
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]
CTD
PMID:20553787
NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312
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Cyp1b1
cytochrome P450, family 1, subfamily b, polypeptide 1
multiple interactions
ISO
chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]
CTD
PMID:20553787
NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917
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Il6
interleukin 6
multiple interactions
ISO
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]
CTD
PMID:20981859
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Mtnr1a
melatonin receptor 1A
affects binding
ISO
chrysoeriol binds to MTNR1A protein
CTD
PMID:20399199
NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919
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Mtnr1b
melatonin receptor 1B
affects binding
ISO
chrysoeriol binds to MTNR1B protein
CTD
PMID:20399199
NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737
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Nqo2
N-ribosyldihydronicotinamide:quinone reductase 2
multiple interactions
ISO
chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]
CTD
PMID:20399199
NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320
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Tnfsf11
TNF superfamily member 11
multiple interactions
ISO
chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]
CTD
PMID:20981859
NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445
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