4',5,7-trihydroxy-3'-methoxyflavone - Ontology Report - Rat Genome Database

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CHEBI ONTOLOGY - ANNOTATIONS

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The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.

Term:	4',5,7-trihydroxy-3'-methoxyflavone	go back to main search page
Accession:	CHEBI:16514	browse the term
Definition:	The 3'-O-methyl derivative of luteolin.
Synonyms:	exact_synonym:	5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-chromen-4-one
	related_synonym:	3'-Methoxyapigenin; 3'-O-Methylluteolin; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4-benzopyrone; 5,7-dihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one; Chryseriol; Chrysoeriol; Formula=C16H12O6; InChI=1S/C16H12O6/c1-21-14-4-8(2-3-10(14)18)13-7-12(20)16-11(19)5-9(17)6-15(16)22-13/h2-7,17-19H,1H3; InChIKey=SCZVLDHREVKTSH-UHFFFAOYSA-N; Luteolin 3'-methyl ether; SMILES=COc1cc(ccc1O)-c1cc(=O)c2c(O)cc(O)cc2o1
	alt_id:	CHEBI:12083; CHEBI:2006; CHEBI:20519
	xref:	Beilstein:295004; CAS:491-71-4; KEGG:C04293; KNApSAcK:C00001029; LIPID_MAPS_instance:LMPK12110799
	xref_mesh:	MESH:C007054
	xref:	MetaCyc:574-TRIHYDROXY-3-METHOXYFLAVONE; PMID:22438130; PMID:22577954; PMID:23017389; PMID:23052184; PMID:23122135; Reaxys:295004
	cyclic_relationship:	is_conjugate_acid_of CHEBI:57799

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Genes (11)

4',5,7-trihydroxy-3'-methoxyflavone

term browser

Symbol

Object Name

Qualifiers

Evidence

Notes

Source

PubMed Reference(s)

RGD Reference(s)

Position

G

ATP binding cassette subfamily C member 1

decreases activity

chrysoeriol results in decreased activity of ABCC1 protein

NCBI chr10:528,961...655,179
Ensembl chr10:531,812...655,114

G

aryl hydrocarbon receptor

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene binds to AHR protein]

NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568

G

bone gamma-carboxyglutamate protein

multiple interactions

chrysoeriol inhibits the reaction [Hydrogen Peroxide results in decreased expression of BGLAP protein]

NCBI chr 2:173,838,518...173,839,495
Ensembl chr 2:173,838,518...173,839,495

G

cytochrome P450, family 1, subfamily a, polypeptide 1

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 mRNA]

NCBI chr 8:58,096,021...58,102,130
Ensembl chr 8:58,096,077...58,102,125

G

cytochrome P450, family 1, subfamily a, polypeptide 2

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A2 mRNA]

NCBI chr 8:58,075,367...58,082,255
Ensembl chr 8:58,075,367...58,082,312

G

cytochrome P450, family 1, subfamily b, polypeptide 1

multiple interactions

chrysoeriol inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1B1 mRNA]

NCBI chr 6:15,342,312...15,350,886
Ensembl chr 6:15,342,344...15,350,917

G

interleukin 6

multiple interactions

chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of IL6 protein]

NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178

G

melatonin receptor 1A

affects binding

chrysoeriol binds to MTNR1A protein

NCBI chr16:47,144,461...47,163,919
Ensembl chr16:47,144,461...47,163,919

G

melatonin receptor 1B

affects binding

chrysoeriol binds to MTNR1B protein

NCBI chr 8:12,638,219...12,652,737
Ensembl chr 8:12,638,219...12,652,737

G

N-ribosyldihydronicotinamide:quinone reductase 2

multiple interactions

chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of 1-benzyl-1,4-dihydronicotinamide] which results in increased reduction of Vitamin K 3]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Ubiquinone Q2]; chrysoeriol inhibits the reaction [[NQO2 protein results in increased oxidation of nicotinamide-beta-riboside] which results in increased reduction of Vitamin K 3]

NCBI chr17:30,909,482...30,938,725
Ensembl chr17:30,909,187...30,938,320

G

TNF superfamily member 11

multiple interactions

chrysoeriol inhibits the reaction [Hydrogen Peroxide results in increased expression of TNFSF11 protein]

NCBI chr15:53,674,990...53,705,171
Ensembl chr15:53,673,877...53,705,445

Term paths to the root

Path 1
Term	Annotations
CHEBI ontology	19757
role	19730
chemical role	19370
antioxidant	15686
4',5,7-trihydroxy-3'-methoxyflavone	11
6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol	0
7-O-(6-p-coumaroylglucosyl)chrysoeriol	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol	0
chrysoeriol 7-O-gentiobioside	0
geraldone	0
isoscoparin +	0
velutin	0
Path 2
Term	Annotations
CHEBI ontology	19757
subatomic particle	19755
composite particle	19755
hadron	19755
baryon	19755
nucleon	19755
atomic nucleus	19755
atom	19755
main group element atom	19703
p-block element atom	19703
carbon group element atom	19649
carbon atom	19645
organic molecular entity	19645
organic molecule	19604
organic cyclic compound	19407
organic heterocyclic compound	18772
oxacycle	17727
benzopyran	11663
1-benzopyran	11429
flavonoid	6782
anthoxanthin	4487
flavones	4487
hydroxyflavone	4474
3'-hydroxyflavonoid	278
luteolin	226
4',5,7-trihydroxy-3'-methoxyflavone	11
6-C-(alpha-L-arabinosyl)-8-C-(beta-L-arabinosyl)chrysoeriol	0
7-O-(6-p-coumaroylglucosyl)chrysoeriol	0
7-O-[alpha-L-rhamnosyl-(1->2)-beta-D-glucosyl]chrysoeriol	0
chrysoeriol 7-O-gentiobioside	0
geraldone	0
isoscoparin +	0
velutin	0

paths to the root