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CHEBI ONTOLOGY - ANNOTATIONS

The Chemical Entities of Biological Interest (ChEBI) ontology is downloaded weekly from EMBL-EBI at http://www.ebi.ac.uk/chebi/. The data is made available under the Creative Commons License (CC BY 3.0, http://creativecommons.org/licenses/by/3.0/). For more information see: Degtyarenko et al. (2008) ChEBI: a database and ontology for chemical entities of biological interest. Nucleic Acids Res. 36, D344–D350.
Term:wogonin
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Accession:CHEBI:10043 term browser browse the term
Definition:A dihydroxy- and monomethoxy-flavone in which the hydroxy groups are positioned at C-5 and C-7 and the methoxy group is at C-8.
Synonyms:exact_synonym: 5,7-dihydroxy-8-methoxy-2-phenyl-4H-chromen-4-one
 related_synonym: 5,7-Dihydroxy-8-methoxyflavone;   5,7-dihydroxy-8-methoxy-2-phenyl-4H-1-benzopyran-4-one;   Formula=C16H12O5;   InChI=1S/C16H12O5/c1-20-15-12(19)7-10(17)14-11(18)8-13(21-16(14)15)9-5-3-2-4-6-9/h2-8,17,19H,1H3;   InChIKey=XLTFNNCXVBYBSX-UHFFFAOYSA-N;   Norwogonin 8-methyl ether;   SMILES=COc1c(O)cc(O)c2c1oc(cc2=O)-c1ccccc1
 xref: Beilstein:287152;   CAS:632-85-9;   KEGG:C10197;   KNApSAcK:C00001111;   LIPID_MAPS_instance:LMPK12111330
 xref_mesh: MESH:C085514
 xref: MetaCyc:CPD-12727;   PMID:10724177;   PMID:11322923;   PMID:19438509;   PMID:22419433;   PMID:23371323;   Reaxys:287152;   Wikipedia:Wogonin
 cyclic_relationship: is_conjugate_acid_of CHEBI:78338

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wogonin term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Alb albumin multiple interactions ISO wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein] CTD PMID:23246481 NCBI chr14:19,176,275...19,191,793
Ensembl chr14:19,176,277...19,191,863 		JBrowse link
G Bax BCL2 associated X, apoptosis regulator multiple interactions
increases expression		 ISO [wogonin co-treated with Fluorouracil] results in increased expression of BAX protein
wogonin results in increased expression of BAX protein		 CTD PMID:20570612, PMID:21457722 NCBI chr 1:101,451,801...101,457,207
Ensembl chr 1:101,451,802...101,457,207 		JBrowse link
G Bcl2 BCL2, apoptosis regulator multiple interactions
decreases expression		 ISO [wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein
wogonin results in decreased expression of BCL2 protein		 CTD PMID:20570612 NCBI chr13:26,605,426...26,769,374
Ensembl chr13:26,605,426...26,769,374 		JBrowse link
G Casp3 caspase 3 increases activity
multiple interactions		 ISO
EXP		 wogonin results in increased activity of CASP3 protein
wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein]
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein]
[wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein		 CTD PMID:20570612, PMID:26756871, PMID:31103702 NCBI chr16:48,845,011...48,863,249
Ensembl chr16:48,845,012...48,863,204 		JBrowse link
G Casp8 caspase 8 multiple interactions ISO wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein] CTD PMID:26756871 NCBI chr 9:65,614,142...65,662,624
Ensembl chr 9:65,614,142...65,662,106 		JBrowse link
G Cat catalase multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein]
wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]		 CTD PMID:26213241, PMID:31103702 NCBI chr 3:93,379,872...93,412,058
Ensembl chr 3:93,379,874...93,412,058 		JBrowse link
G Cav1 caveolin 1 multiple interactions ISO wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein] CTD PMID:23246481 NCBI chr 4:44,597,123...44,630,206
Ensembl chr 4:44,597,123...44,630,200 		JBrowse link
G Ccna2 cyclin A2 decreases expression ISO wogonin results in decreased expression of CCNA2 protein CTD PMID:21457722 NCBI chr 2:123,274,727...123,282,266
Ensembl chr 2:123,275,881...123,282,214 		JBrowse link
G Ccnd1 cyclin D1 decreases expression ISO
EXP		 wogonin results in decreased expression of CCND1 protein CTD PMID:21457722, PMID:23872260 NCBI chr 1:218,090,750...218,100,447
Ensembl chr 1:218,090,750...218,100,325 		JBrowse link
G Cdk2 cyclin dependent kinase 2 decreases expression ISO
EXP		 wogonin results in decreased expression of CDK2 protein CTD PMID:23872260 NCBI chr 7:3,124,953...3,132,533
Ensembl chr 7:3,124,954...3,132,457 		JBrowse link
G Cdk4 cyclin-dependent kinase 4 decreases expression ISO
EXP		 wogonin results in decreased expression of CDK4 protein CTD PMID:23872260 NCBI chr 7:70,345,971...70,352,689
Ensembl chr 7:70,349,863...70,352,418 		JBrowse link
G Cdkn1a cyclin-dependent kinase inhibitor 1A increases expression ISO wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein CTD PMID:32671444 NCBI chr20:6,348,422...6,358,864
Ensembl chr20:6,351,458...6,358,864 		JBrowse link
G Cdkn1b cyclin-dependent kinase inhibitor 1B increases expression ISO
EXP		 wogonin results in increased expression of CDKN1B protein CTD PMID:23872260 NCBI chr 4:168,689,043...168,694,159
Ensembl chr 4:168,689,163...168,693,964 		JBrowse link
G Cdkn2a cyclin-dependent kinase inhibitor 2A increases expression ISO wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein CTD PMID:32671444 NCBI chr 5:107,823,323...107,832,405
Ensembl chr 5:107,823,330...107,841,175 		JBrowse link
G Ctnnb1 catenin beta 1 decreases expression
multiple interactions
increases expression		 ISO
EXP		 wogonin results in decreased expression of CTNNB1 protein
Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein]
wogonin results in increased expression of CTNNB1 protein modified form		 CTD PMID:23872260, PMID:31103702 NCBI chr 8:129,601,511...129,628,378
Ensembl chr 8:129,617,812...129,627,372 		JBrowse link
G Cyp1a1 cytochrome P450, family 1, subfamily a, polypeptide 1 multiple interactions
decreases expression		 ISO wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]
wogonin results in decreased expression of CYP1A1 mRNA		 CTD PMID:18451504 NCBI chr 8:62,472,087...62,478,122
Ensembl chr 8:62,472,095...62,478,147 		JBrowse link
G Dpyd dihydropyrimidine dehydrogenase decreases expression ISO wogonin results in decreased expression of DPYD mRNA CTD PMID:20570612 NCBI chr 2:221,823,692...222,694,627
Ensembl chr 2:221,823,687...222,694,627 		JBrowse link
G Gfap glial fibrillary acidic protein multiple interactions
increases expression		 ISO
EXP		 Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein] CTD PMID:23872260 NCBI chr10:90,990,762...90,999,435
Ensembl chr10:90,990,762...90,999,506 		JBrowse link
G Glb1 galactosidase, beta 1 increases expression ISO wogonin results in increased expression of GLB1 protein CTD PMID:32671444 NCBI chr 8:122,439,328...122,511,939
Ensembl chr 8:122,439,328...122,511,939 		JBrowse link
G Gsk3b glycogen synthase kinase 3 beta decreases expression
increases expression		 ISO
EXP		 wogonin results in decreased expression of GSK3B protein modified form
wogonin results in increased expression of GSK3B protein		 CTD PMID:23872260 NCBI chr11:65,060,884...65,208,842
Ensembl chr11:65,066,235...65,209,268 		JBrowse link
G Hif1a hypoxia inducible factor 1 subunit alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein] CTD PMID:26213241 NCBI chr 6:96,810,868...96,856,303
Ensembl chr 6:96,810,907...96,856,052 		JBrowse link
G Ifng interferon gamma multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 7:61,337,383...61,341,419
Ensembl chr 7:61,337,381...61,341,419 		JBrowse link
G Il1b interleukin 1 beta multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]		 CTD PMID:26213241, PMID:31103702 NCBI chr 3:121,876,256...121,882,637
Ensembl chr 3:121,876,263...121,882,726 		JBrowse link
G Il6 interleukin 6 increases expression
increases secretion		 ISO wogonin results in increased expression of IL6 protein
wogonin results in increased secretion of IL6 protein
wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein		 CTD PMID:32671444 NCBI chr 4:3,043,231...3,047,807
Ensembl chr 4:3,043,231...3,047,807 		JBrowse link
G Jun Jun proto-oncogene, AP-1 transcription factor subunit multiple interactions ISO wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] CTD PMID:17570322 NCBI chr 5:114,011,184...114,014,277
Ensembl chr 5:114,011,189...114,014,277 		JBrowse link
G Map2k1 mitogen activated protein kinase kinase 1 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein] CTD PMID:23362215 NCBI chr 8:69,134,218...69,722,573
Ensembl chr 8:69,134,223...69,164,758 		JBrowse link
G Map2k2 mitogen activated protein kinase kinase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein] CTD PMID:23362215 NCBI chr 7:11,458,971...11,478,520
Ensembl chr 7:11,458,967...11,478,489 		JBrowse link
G Mapk1 mitogen activated protein kinase 1 multiple interactions
decreases phosphorylation		 ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein]
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
wogonin results in decreased phosphorylation of MAPK1 protein		 CTD PMID:21295103, PMID:23362215, PMID:26892447 NCBI chr11:88,203,863...88,273,301
Ensembl chr11:88,211,599...88,273,254 		JBrowse link
G Mapk3 mitogen activated protein kinase 3 multiple interactions
decreases phosphorylation		 ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein]
wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
wogonin results in decreased phosphorylation of MAPK3 protein		 CTD PMID:21295103, PMID:23362215, PMID:26892447 NCBI chr 1:198,192,773...198,198,975
Ensembl chr 1:198,192,773...198,198,975 		JBrowse link
G Mapk8 mitogen-activated protein kinase 8 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein] CTD PMID:23362215 NCBI chr16:9,620,854...9,709,342
Ensembl chr16:9,625,177...9,709,347 		JBrowse link
G Mapk9 mitogen-activated protein kinase 9 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein] CTD PMID:23362215 NCBI chr10:35,333,859...35,374,364
Ensembl chr10:35,333,859...35,374,355 		JBrowse link
G Mki67 marker of proliferation Ki-67 decreases expression ISO wogonin results in decreased expression of MKI67 protein CTD PMID:32671444 NCBI chr 1:207,993,895...208,020,454
Ensembl chr 1:207,993,895...208,020,454 		JBrowse link
G Mmp2 matrix metallopeptidase 2 multiple interactions ISO wogonin results in decreased expression of and results in decreased activity of MMP2 protein CTD PMID:21295103 NCBI chr19:15,542,771...15,570,589
Ensembl chr19:15,542,765...15,570,611 		JBrowse link
G Mmp9 matrix metallopeptidase 9 multiple interactions EXP
ISO		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein]
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein		 CTD PMID:14700523, PMID:21295103 NCBI chr 3:161,413,410...161,421,473
Ensembl chr 3:161,413,298...161,421,520 		JBrowse link
G Nat1 N-acetyltransferase 1 decreases expression ISO wogonin results in decreased expression of NAT1 mRNA; wogonin results in decreased expression of NAT1 protein CTD PMID:15816529 NCBI chr16:23,970,742...23,991,573
Ensembl chr16:23,970,743...23,991,573 		JBrowse link
G Nfkbia NFKB inhibitor alpha multiple interactions ISO wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of NFKBIA protein] CTD PMID:26213241 NCBI chr 6:76,267,227...76,270,457
Ensembl chr 6:76,267,228...76,270,457 		JBrowse link
G Nos2 nitric oxide synthase 2 multiple interactions ISO
EXP		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein]
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NOS2 protein]		 CTD PMID:14700523, PMID:17570322, PMID:23362215, PMID:26892447 NCBI chr10:66,188,290...66,221,621
Ensembl chr10:66,189,786...66,313,190 		JBrowse link
G Ogg1 8-oxoguanine DNA glycosylase multiple interactions ISO wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA] CTD PMID:23872129 NCBI chr 4:145,282,828...145,289,367
Ensembl chr 4:145,282,797...145,289,326 		JBrowse link
G Pkm pyruvate kinase M1/2 multiple interactions ISO wogonin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate] CTD PMID:25388478 NCBI chr 8:64,480,963...64,502,957
Ensembl chr 8:64,481,172...64,502,722 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma multiple interactions EXP wogonin inhibits the reaction [Cisplatin results in decreased expression of PPARG protein] CTD PMID:31103702 NCBI chr 4:147,274,055...147,399,383
Ensembl chr 4:147,274,107...147,399,380 		JBrowse link
G Prkci protein kinase C, iota multiple interactions ISO wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein] CTD PMID:21295103 NCBI chr 2:115,941,998...116,002,550
Ensembl chr 2:115,941,993...116,002,561 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein] CTD PMID:23362215, PMID:26892447 NCBI chr13:67,351,230...67,356,920
Ensembl chr13:67,351,087...67,359,335 		JBrowse link
G Rela RELA proto-oncogene, NF-kB subunit multiple interactions
increases phosphorylation		 ISO
EXP		 wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein]
wogonin results in increased phosphorylation of RELA protein
wogonin inhibits the reaction [Cisplatin results in increased expression of RELA protein]		 CTD PMID:23362215, PMID:26213241, PMID:31103702, PMID:32671444 NCBI chr 1:220,992,770...221,003,249
Ensembl chr 1:220,992,770...221,003,249 		JBrowse link
G Slc22a6 solute carrier family 22 member 6 multiple interactions
decreases activity		 ISO [wogonin results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I CTD PMID:32159797 NCBI chr 1:224,824,809...224,833,284
Ensembl chr 1:224,824,799...224,833,259 		JBrowse link
G Slc22a8 solute carrier family 22 member 8 decreases activity
multiple interactions		 ISO wogonin results in decreased activity of SLC22A8 protein
[wogonin results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I		 CTD PMID:32159797 NCBI chr 1:224,799,444...224,818,482
Ensembl chr 1:224,800,252...224,818,482 		JBrowse link
G Src SRC proto-oncogene, non-receptor tyrosine kinase multiple interactions ISO wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein] CTD PMID:23362215 NCBI chr 3:153,547,807...153,595,643
Ensembl chr 3:153,580,861...153,595,642 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 decreases phosphorylation ISO wogonin results in decreased phosphorylation of STAT3 protein CTD PMID:32671444 NCBI chr10:88,790,401...88,842,263
Ensembl chr10:88,790,408...88,842,233 		JBrowse link
G Tnf tumor necrosis factor multiple interactions ISO
EXP		 wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]
wogonin inhibits the reaction [Cisplatin results in increased expression of TNF protein]		 CTD PMID:26213241, PMID:31103702 NCBI chr20:5,189,382...5,192,000
Ensembl chr20:5,189,390...5,192,000 		JBrowse link
G Tp53 tumor protein p53 increases expression ISO wogonin results in increased expression of TP53 protein CTD PMID:21457722 NCBI chr10:56,186,299...56,198,449
Ensembl chr10:56,187,020...56,198,449 		JBrowse link
G Txnrd2 thioredoxin reductase 2 decreases expression ISO wogonin results in decreased expression of TXNRD2 mRNA; wogonin results in decreased expression of TXNRD2 protein CTD PMID:32671444 NCBI chr11:86,667,994...86,716,063
Ensembl chr11:86,667,997...86,716,254 		JBrowse link
G Tyms thymidylate synthetase multiple interactions
increases expression		 ISO [wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA
wogonin results in increased expression of TYMS mRNA		 CTD PMID:20570612 NCBI chr 9:121,918,875...121,931,564
Ensembl chr 9:121,918,947...121,931,564 		JBrowse link
G Umps uridine monophosphate synthetase multiple interactions
decreases expression		 ISO Fluorouracil inhibits the reaction [wogonin results in decreased expression of UMPS mRNA] CTD PMID:20570612 NCBI chr11:70,034,181...70,044,590
Ensembl chr11:70,034,139...70,044,628 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  CHEBI ontology 19787
    role 19734
      application 19393
        pharmaceutical 19275
          drug 19275
            antineoplastic agent 16985
              wogonin 52
                wogonin 7-O-beta-D-glucuronide 0
Path 2
Term Annotations click to browse term
  CHEBI ontology 19787
    subatomic particle 19784
      composite particle 19784
        hadron 19784
          baryon 19784
            nucleon 19784
              atomic nucleus 19784
                atom 19784
                  main group element atom 19672
                    p-block element atom 19672
                      carbon group element atom 19574
                        carbon atom 19563
                          organic molecular entity 19563
                            organic molecule 19488
                              organic cyclic compound 19285
                                organic heterocyclic compound 18410
                                  oxacycle 17185
                                    benzopyran 10135
                                      1-benzopyran 9851
                                        flavonoid 6374
                                          flavones 4166
                                            methoxyflavone 416
                                              monomethoxyflavone 138
                                                wogonin 52
                                                  wogonin 7-O-beta-D-glucuronide 0
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.