|
G
|
Adipoq
|
adiponectin, C1Q and collagen domain containing
|
increases expression
|
ISO
|
wogonin analog results in increased expression of ADIPOQ protein; wogonin results in increased expression of ADIPOQ protein
|
CTD |
PMID:30445784 |
|
NCBI chr11:77,721,912...77,735,644
Ensembl chr11:91,226,180...91,240,169
|
|
G
|
Akt1
|
AKT serine/threonine kinase 1
|
multiple interactions decreases phosphorylation decreases expression
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of AKT1 protein] wogonin results in decreased phosphorylation of AKT1 protein wogonin results in decreased expression of AKT1 mRNA
|
CTD |
PMID:37004399 PMID:38134066 |
|
NCBI chr 6:137,534,810...137,555,131
Ensembl chr 6:137,535,390...137,552,610
|
|
G
|
Alb
|
albumin
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Hydrogen Peroxide results in increased uptake of ALB protein]
|
CTD |
PMID:23246481 |
|
NCBI chr14:17,891,564...17,907,043
Ensembl chr14:17,891,582...17,911,865
|
|
G
|
Bax
|
BCL2 associated X, apoptosis regulator
|
multiple interactions increases expression
|
ISO
|
[wogonin co-treated with Fluorouracil] results in increased expression of BAX protein wogonin results in increased expression of BAX protein
|
CTD |
PMID:20570612 PMID:21457722 |
|
NCBI chr 1:105,076,472...105,081,906
Ensembl chr 1:105,076,473...105,086,429
|
|
G
|
Bcl2
|
BCL2, apoptosis regulator
|
multiple interactions decreases expression
|
ISO
|
[wogonin co-treated with Fluorouracil] results in decreased expression of BCL2 protein wogonin results in decreased expression of BCL2 protein
|
CTD |
PMID:20570612 |
|
NCBI chr13:23,204,464...23,366,900
Ensembl chr13:23,204,464...23,366,900
|
|
G
|
Casp3
|
caspase 3
|
increases activity multiple interactions increases expression
|
ISO EXP
|
wogonin results in increased activity of CASP3 protein [wogonin co-treated with Fluorouracil] results in increased activity of CASP3 protein wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP3 protein] wogonin inhibits the reaction [Cisplatin results in increased expression of and results in increased activity of CASP3 protein] wogonin results in increased expression of CASP3 mRNA
|
CTD |
PMID:20570612 PMID:26756871 PMID:31103702 PMID:38134066 |
|
NCBI chr16:52,395,539...52,413,794
Ensembl chr16:52,395,540...52,413,732
|
|
G
|
Casp8
|
caspase 8
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Bisphenol A-Glycidyl Methacrylate results in increased activity of CASP8 protein]
|
CTD |
PMID:26756871 |
|
NCBI chr 9:60,263,863...60,312,542
Ensembl chr 9:67,758,033...67,806,699
|
|
G
|
Cat
|
catalase
|
multiple interactions
|
ISO EXP
|
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in decreased activity of CAT protein] wogonin inhibits the reaction [Cisplatin results in decreased activity of CAT protein]
|
CTD |
PMID:26213241 PMID:31103702 |
|
NCBI chr 3:110,297,340...110,329,526
Ensembl chr 3:110,297,342...110,329,526
|
|
G
|
Cav1
|
caveolin 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Anisomycin results in increased phosphorylation of CAV1 protein]; wogonin inhibits the reaction [Hydrogen Peroxide results in increased phosphorylation of CAV1 protein]
|
CTD |
PMID:23246481 |
|
NCBI chr 4:46,606,538...46,639,616
Ensembl chr 4:46,600,738...46,639,740
|
|
G
|
Ccna2
|
cyclin A2
|
decreases expression
|
ISO
|
wogonin results in decreased expression of CCNA2 protein
|
CTD |
PMID:21457722 |
|
NCBI chr 2:119,427,239...119,433,645
Ensembl chr 2:121,355,363...121,361,701
|
|
G
|
Ccnd1
|
cyclin D1
|
decreases expression
|
ISO EXP
|
wogonin results in decreased expression of CCND1 protein
|
CTD |
PMID:21457722 PMID:23872260 |
|
NCBI chr 1:209,518,288...209,527,986
Ensembl chr 1:209,518,288...209,527,810
|
|
G
|
Cdk2
|
cyclin dependent kinase 2
|
decreases expression
|
ISO EXP
|
wogonin results in decreased expression of CDK2 protein
|
CTD |
PMID:23872260 |
|
NCBI chr 7:1,714,392...1,721,964
Ensembl chr 7:1,714,392...1,721,878
|
|
G
|
Cdk4
|
cyclin-dependent kinase 4
|
decreases expression
|
ISO EXP
|
wogonin results in decreased expression of CDK4 protein
|
CTD |
PMID:23872260 |
|
NCBI chr 7:64,771,453...64,774,891
Ensembl chr 7:64,771,147...64,775,163
|
|
G
|
Cdk7
|
cyclin-dependent kinase 7
|
decreases activity
|
ISO
|
wogonin results in decreased activity of CDK7 protein
|
CTD |
PMID:37515497 |
|
NCBI chr 2:33,574,623...33,599,485
Ensembl chr 2:33,574,623...33,599,485
|
|
G
|
Cdk9
|
cyclin-dependent kinase 9
|
decreases activity
|
ISO
|
wogonin results in decreased activity of CDK9 protein
|
CTD |
PMID:37515497 |
|
NCBI chr 3:15,996,467...16,001,315
Ensembl chr 3:36,394,169...36,399,528
|
|
G
|
Cdkn1a
|
cyclin-dependent kinase inhibitor 1A
|
increases expression
|
ISO
|
wogonin results in increased expression of CDKN1A mRNA; wogonin results in increased expression of CDKN1A protein
|
CTD |
PMID:32671444 |
|
NCBI chr20:7,150,820...7,161,373
Ensembl chr20:7,153,958...7,164,969
|
|
G
|
Cdkn1b
|
cyclin-dependent kinase inhibitor 1B
|
increases expression
|
ISO EXP
|
wogonin results in increased expression of CDKN1B protein
|
CTD |
PMID:23872260 |
|
NCBI chr 4:169,491,273...169,496,500
Ensembl chr 4:169,490,876...169,496,498
|
|
G
|
Cdkn2a
|
cyclin-dependent kinase inhibitor 2A
|
increases expression
|
ISO
|
wogonin results in increased expression of CDKN2A mRNA; wogonin results in increased expression of CDKN2A protein
|
CTD |
PMID:32671444 |
|
NCBI chr 5:109,100,763...109,114,448
Ensembl chr 5:109,100,772...109,119,248
|
|
G
|
Cebpa
|
CCAAT/enhancer binding protein alpha
|
increases expression
|
ISO
|
wogonin analog results in increased expression of CEBPA protein; wogonin results in increased expression of CEBPA protein
|
CTD |
PMID:30445784 |
|
NCBI chr 1:87,759,631...87,762,303
Ensembl chr 1:96,896,171...96,899,309
|
|
G
|
Chrm4
|
cholinergic receptor, muscarinic 4
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in decreased expression of CHRM4 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 3:77,893,425...77,901,166
Ensembl chr 3:98,348,650...98,358,771
|
|
G
|
Ctnnb1
|
catenin beta 1
|
decreases expression increases expression multiple interactions
|
ISO EXP
|
wogonin results in decreased expression of CTNNB1 protein wogonin results in increased expression of CTNNB1 protein modified form Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein] Lithium Chloride inhibits the reaction [wogonin results in decreased expression of CTNNB1 protein]; wogonin inhibits the reaction [Cisplatin results in increased expression of CTNNB1 protein]
|
CTD |
PMID:23872260 PMID:31103702 |
|
NCBI chr 8:129,517,576...129,544,661
Ensembl chr 8:129,517,545...129,544,662
|
|
G
|
Cyp1a1
|
cytochrome P450, family 1, subfamily a, polypeptide 1
|
multiple interactions decreases expression
|
ISO
|
wogonin affects the reaction [Benzo(a)pyrene affects the activity of CYP1A1 protein]; wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of CYP1A1 protein]; wogonin inhibits the reaction [Tetrachlorodibenzodioxin results in increased expression of CYP1A1 mRNA]; wogonin results in decreased expression of and results in decreased activity of CYP1A1 protein wogonin results in decreased expression of CYP1A1 mRNA
|
CTD |
PMID:18451504 PMID:37515497 |
|
NCBI chr 8:66,991,940...66,998,014
Ensembl chr 8:66,991,970...66,998,012
|
|
G
|
Dio1
|
iodothyronine deiodinase 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of DIO1 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 5:127,303,089...127,319,784
Ensembl chr 5:127,303,083...127,319,771
|
|
G
|
Dpyd
|
dihydropyrimidine dehydrogenase
|
decreases expression
|
ISO
|
wogonin results in decreased expression of DPYD mRNA
|
CTD |
PMID:20570612 |
|
NCBI chr 2:209,293,902...210,159,777
Ensembl chr 2:209,293,929...210,159,778
|
|
G
|
Gabra1
|
gamma-aminobutyric acid type A receptor subunit alpha 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of GABRA1 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr10:26,595,151...26,650,611
Ensembl chr10:27,096,740...27,152,442
|
|
G
|
Gfap
|
glial fibrillary acidic protein
|
multiple interactions increases expression
|
ISO EXP
|
Lithium Chloride inhibits the reaction [wogonin results in increased expression of GFAP protein]
|
CTD |
PMID:23872260 |
|
NCBI chr10:87,852,891...87,861,631
Ensembl chr10:88,352,986...88,361,685
|
|
G
|
Glb1
|
galactosidase, beta 1
|
increases expression
|
ISO
|
wogonin results in increased expression of GLB1 protein
|
CTD |
PMID:32671444 |
|
NCBI chr 8:114,085,508...114,158,127
Ensembl chr 8:122,963,718...123,036,326
|
|
G
|
Gsk3b
|
glycogen synthase kinase 3 beta
|
decreases expression increases expression
|
ISO EXP
|
wogonin results in decreased expression of GSK3B protein modified form wogonin results in increased expression of GSK3B protein
|
CTD |
PMID:23872260 |
|
NCBI chr11:76,004,502...76,154,665
Ensembl chr11:76,009,507...76,153,249
|
|
G
|
H2ax
|
H2A.X variant histone
|
increases expression multiple interactions
|
ISO
|
wogonin results in increased expression of H2AX protein wogonin inhibits the reaction [Benzo(a)pyrene results in increased expression of H2AX protein]
|
CTD |
PMID:32671444 PMID:37515497 |
|
NCBI chr 8:53,568,718...53,570,072
Ensembl chr 8:53,568,281...53,573,079
|
|
G
|
Hif1a
|
hypoxia inducible factor 1 subunit alpha
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of HIF1A protein]
|
CTD |
PMID:26213241 |
|
NCBI chr 6:98,357,788...98,405,068
Ensembl chr 6:98,359,910...98,405,323
|
|
G
|
Htr3a
|
5-hydroxytryptamine receptor 3A
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of HTR3A mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 8:58,138,514...58,150,960
Ensembl chr 8:58,138,226...58,150,884
|
|
G
|
Ifng
|
interferon gamma
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Dinoprostone]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased abundance of Nitric Oxide]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein]
|
CTD |
PMID:23362215 |
|
NCBI chr 7:55,789,180...55,793,216
Ensembl chr 7:55,761,736...55,793,216
|
|
G
|
Ikbkb
|
inhibitor of nuclear factor kappa B kinase subunit beta
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of and results in increased phosphorylation of IKBKB protein]
|
CTD |
PMID:37004399 |
|
NCBI chr16:76,021,968...76,075,717
Ensembl chr16:76,022,008...76,081,911
|
|
G
|
Il13
|
interleukin 13
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of IL13 protein]
|
CTD |
PMID:37004399 |
|
NCBI chr10:38,290,926...38,293,483
Ensembl chr10:38,290,926...38,293,483
|
|
G
|
Il17a
|
interleukin 17A
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of IL17A protein]
|
CTD |
PMID:37004399 |
|
NCBI chr 9:30,640,844...30,644,331
Ensembl chr 9:30,640,844...30,644,331
|
|
G
|
Il1b
|
interleukin 1 beta
|
multiple interactions
|
ISO EXP
|
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of IL1B protein] wogonin inhibits the reaction [Cisplatin results in increased expression of IL1B protein]
|
CTD |
PMID:26213241 PMID:31103702 |
|
NCBI chr 3:137,030,200...137,036,581
Ensembl chr 3:137,030,205...137,036,601
|
|
G
|
Il5
|
interleukin 5
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of IL5 protein]
|
CTD |
PMID:37004399 |
|
NCBI chr10:38,375,132...38,378,003
Ensembl chr10:38,375,132...38,378,003
|
|
G
|
Il6
|
interleukin 6
|
increases expression increases secretion
|
ISO
|
wogonin results in increased expression of IL6 protein wogonin results in increased expression of IL6 mRNA; wogonin results in increased expression of IL6 protein wogonin results in increased secretion of IL6 protein
|
CTD |
PMID:32671444 |
|
NCBI chr 4:5,889,999...5,894,575
Ensembl chr 4:5,889,999...5,894,610
|
|
G
|
Ins1
|
insulin 1
|
increases secretion decreases secretion
|
EXP
|
wogonin analog results in increased secretion of INS1 protein wogonin results in decreased secretion of INS1 protein
|
CTD |
PMID:30445784 |
|
NCBI chr 1:261,186,119...261,186,686
Ensembl chr 1:261,186,119...261,186,682
|
|
G
|
Ins2
|
insulin 2
|
increases response to substance
|
ISO
|
wogonin results in increased susceptibility to INS protein
|
CTD |
PMID:28854906 |
|
NCBI chr 1:207,272,738...207,421,998
Ensembl chr 1:207,272,742...207,273,805
|
|
G
|
Jun
|
Jun proto-oncogene, AP-1 transcription factor subunit
|
multiple interactions decreases expression
|
ISO
|
wogonin inhibits the reaction [Lipopolysaccharides results in increased phosphorylation of JUN protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased phosphorylation of JUN protein] wogonin results in decreased expression of JUN mRNA
|
CTD |
PMID:17570322 PMID:38134066 |
|
NCBI chr 5:115,009,900...115,012,993
Ensembl chr 5:114,973,151...115,013,285
|
|
G
|
Klf4
|
KLF transcription factor 4
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [angiotensin II increases expression of KLF4 protein in vascular smooth muscle cells]
|
RGD |
PMID:29127880 |
RGD:155230825 |
NCBI chr 5:75,074,107...75,079,182
Ensembl chr 5:75,074,236...75,078,592
|
|
G
|
Lep
|
leptin
|
decreases expression
|
ISO
|
wogonin analog results in decreased expression of LEP protein; wogonin results in decreased expression of LEP protein
|
CTD |
PMID:30445784 |
|
NCBI chr 4:58,626,529...58,640,663
Ensembl chr 4:58,626,523...58,640,661
|
|
G
|
Map2k1
|
mitogen activated protein kinase kinase 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K1 protein]
|
CTD |
PMID:23362215 |
|
NCBI chr 8:73,578,747...73,650,184
Ensembl chr 8:73,578,752...73,650,184
|
|
G
|
Map2k2
|
mitogen activated protein kinase kinase 2
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAP2K2 protein]
|
CTD |
PMID:23362215 |
|
NCBI chr 7:9,241,449...9,264,216
Ensembl chr 7:9,241,310...9,260,940
|
|
G
|
Mapk1
|
mitogen activated protein kinase 1
|
multiple interactions decreases phosphorylation
|
ISO
|
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK1 protein] wogonin results in decreased phosphorylation of MAPK1 protein wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK1 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK1 protein]
|
CTD |
PMID:21295103 PMID:23362215 PMID:26892447 |
|
NCBI chr11:97,462,025...97,529,193
Ensembl chr11:97,462,025...97,527,825
|
|
G
|
Mapk3
|
mitogen activated protein kinase 3
|
multiple interactions decreases phosphorylation
|
ISO
|
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased phosphorylation of MAPK3 protein] wogonin results in decreased phosphorylation of MAPK3 protein wogonin affects the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of MAPK3 protein]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK3 protein]
|
CTD |
PMID:21295103 PMID:23362215 PMID:26892447 |
|
NCBI chr 1:190,797,189...190,803,411
Ensembl chr 1:190,797,185...190,803,411
|
|
G
|
Mapk8
|
mitogen-activated protein kinase 8
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK8 protein]
|
CTD |
PMID:23362215 |
|
NCBI chr16:8,645,171...8,728,225
Ensembl chr16:8,645,198...8,728,427
|
|
G
|
Mapk9
|
mitogen-activated protein kinase 9
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of MAPK9 protein]
|
CTD |
PMID:23362215 |
|
NCBI chr10:34,670,750...34,711,972
Ensembl chr10:34,670,756...34,712,228
|
|
G
|
Mki67
|
marker of proliferation Ki-67
|
decreases expression
|
ISO
|
wogonin results in decreased expression of MKI67 protein
|
CTD |
PMID:32671444 |
|
NCBI chr 1:199,926,150...199,952,847
Ensembl chr 1:199,926,150...199,952,593
|
|
G
|
Mmp2
|
matrix metallopeptidase 2
|
multiple interactions
|
ISO
|
wogonin results in decreased expression of and results in decreased activity of MMP2 protein
|
CTD |
PMID:21295103 |
|
NCBI chr19:30,327,643...30,355,856
Ensembl chr19:30,327,643...30,355,856
|
|
G
|
Mmp9
|
matrix metallopeptidase 9
|
multiple interactions
|
EXP ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased activity of MMP9 protein] wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased expression of and results in increased activity of MMP9 protein]; wogonin results in decreased expression of and results in decreased activity of MMP9 protein
|
CTD |
PMID:14700523 PMID:21295103 |
|
NCBI chr 3:174,103,474...174,111,434
Ensembl chr 3:174,084,123...174,111,442
|
|
G
|
Nat1
|
N-acetyltransferase 1
|
decreases expression
|
ISO
|
wogonin results in decreased expression of NAT1 mRNA; wogonin results in decreased expression of NAT1 protein
|
CTD |
PMID:15816529 |
|
NCBI chr16:26,984,882...27,005,194
Ensembl chr16:26,982,625...26,986,527
|
|
G
|
Ncoa2
|
nuclear receptor coactivator 2
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of NCOA2 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 5:5,835,642...6,069,693
Ensembl chr 5:10,618,722...10,852,776
|
|
G
|
Nfkbia
|
NFKB inhibitor alpha
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased degradation of NFKBIA protein]
|
CTD |
PMID:26213241 |
|
NCBI chr 6:78,593,844...78,597,307
Ensembl chr 6:78,593,847...78,597,072
|
|
G
|
Nos2
|
nitric oxide synthase 2
|
multiple interactions
|
ISO EXP
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of NOS2 protein]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [Lipopolysaccharides results in increased expression of NOS2 protein]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 mRNA]; wogonin inhibits the reaction [lipoteichoic acid results in increased expression of NOS2 protein] wogonin inhibits the reaction [[Lipopolysaccharides co-treated with Tetradecanoylphorbol Acetate] results in increased expression of NOS2 protein]
|
CTD |
PMID:14700523 PMID:17570322 PMID:23362215 PMID:26892447 |
|
NCBI chr10:64,313,335...64,349,221
Ensembl chr10:64,313,335...64,401,880
|
|
G
|
Ogg1
|
8-oxoguanine DNA glycosylase
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Etoposide results in decreased expression of OGG1 mRNA]
|
CTD |
PMID:23872129 |
|
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:148,030,349...148,037,604
|
|
G
|
Pik3ca
|
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of PIK3CA protein]
|
CTD |
PMID:37004399 |
|
NCBI chr 2:117,103,643...117,177,411
Ensembl chr 2:117,143,468...117,177,411
|
|
G
|
Pkm
|
pyruvate kinase M1/2
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [PKM protein results in increased metabolism of Phosphoenolpyruvate]
|
CTD |
PMID:25388478 |
|
NCBI chr 8:60,057,629...60,079,600
Ensembl chr 8:68,948,815...68,975,396
|
|
G
|
Pparg
|
peroxisome proliferator-activated receptor gamma
|
multiple interactions
|
EXP
|
wogonin inhibits the reaction [Cisplatin results in decreased expression of PPARG protein]
|
CTD |
PMID:31103702 |
|
NCBI chr 4:150,095,743...150,221,104
Ensembl chr 4:150,095,787...150,221,104
|
|
G
|
Prkci
|
protein kinase C, iota
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased localization of PRKCI protein]
|
CTD |
PMID:21295103 |
|
NCBI chr 2:112,321,919...112,382,305
Ensembl chr 2:114,250,398...114,310,784
|
|
G
|
Prss1
|
serine protease 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of PRSS1 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 4:70,364,589...70,367,792
Ensembl chr 4:71,331,246...71,334,452
|
|
G
|
Ptgs1
|
prostaglandin-endoperoxide synthase 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of PTGS1 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 3:39,981,419...40,002,993
Ensembl chr 3:39,981,415...40,002,990
|
|
G
|
Ptgs2
|
prostaglandin-endoperoxide synthase 2
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 mRNA]; wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased expression of PTGS2 protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of PTGS2 protein]
|
CTD |
PMID:23362215 PMID:26892447 |
|
NCBI chr13:64,714,063...64,722,320
Ensembl chr13:64,713,619...64,722,320
|
|
G
|
Rbp4
|
retinol binding protein 4
|
decreases expression
|
ISO
|
wogonin analog results in decreased expression of RBP4 protein; wogonin results in decreased expression of RBP4 protein
|
CTD |
PMID:30445784 |
|
NCBI chr 1:245,306,349...245,313,551
Ensembl chr 1:245,306,349...245,313,898
|
|
G
|
Rela
|
RELA proto-oncogene, NF-kB subunit
|
multiple interactions increases phosphorylation
|
ISO EXP
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of RELA protein]; wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased phosphorylation of RELA protein] wogonin inhibits the reaction [Cisplatin results in increased expression of RELA protein] wogonin results in increased phosphorylation of RELA protein
|
CTD |
PMID:23362215 PMID:26213241 PMID:31103702 PMID:32671444 |
|
NCBI chr 1:212,354,336...212,364,815
Ensembl chr 1:212,333,035...212,364,817
|
|
G
|
Runx1t1
|
RUNX1 partner transcriptional co-repressor 1
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [Ovalbumin results in increased expression of RUNX1T1 mRNA]
|
CTD |
PMID:37004399 |
|
NCBI chr 5:27,187,674...27,338,070
Ensembl chr 5:31,984,855...32,132,855
|
|
G
|
Slc22a6
|
solute carrier family 22 member 6
|
multiple interactions decreases activity
|
ISO
|
[wogonin results in decreased activity of SLC22A6 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I
|
CTD |
PMID:32159797 |
|
NCBI chr 1:214,951,493...214,960,317
Ensembl chr 1:214,951,867...214,960,311
|
|
G
|
Slc22a8
|
solute carrier family 22 member 8
|
decreases activity multiple interactions
|
ISO
|
wogonin results in decreased activity of SLC22A8 protein [wogonin results in decreased activity of SLC22A8 protein] which results in increased susceptibility to and results in increased activity of aristolochic acid I
|
CTD |
PMID:32159797 |
|
NCBI chr 1:214,925,506...214,945,516
Ensembl chr 1:214,925,508...214,946,588
|
|
G
|
Slc2a4
|
solute carrier family 2 member 4
|
increases expression
|
ISO
|
wogonin analog results in increased expression of SLC2A4 protein; wogonin results in increased expression of SLC2A4 protein
|
CTD |
PMID:30445784 |
|
NCBI chr10:55,164,721...55,170,289
Ensembl chr10:55,164,721...55,170,270
|
|
G
|
Src
|
SRC proto-oncogene, non-receptor tyrosine kinase
|
multiple interactions
|
ISO
|
wogonin inhibits the reaction [[Lipopolysaccharides co-treated with IFNG protein] results in increased phosphorylation of SRC protein]
|
CTD |
PMID:23362215 |
|
NCBI chr 3:166,511,616...166,559,463
Ensembl chr 3:166,511,985...166,559,462
|
|
G
|
Stat3
|
signal transducer and activator of transcription 3
|
decreases phosphorylation
|
ISO
|
wogonin results in decreased phosphorylation of STAT3 protein
|
CTD |
PMID:32671444 |
|
NCBI chr10:86,311,528...86,363,513
Ensembl chr10:86,311,535...86,363,359
|
|
G
|
Tnf
|
tumor necrosis factor
|
multiple interactions decreases expression
|
ISO EXP
|
wogonin inhibits the reaction [lipopolysaccharide, Escherichia coli O111 B4 results in increased expression of TNF protein]; wogonin inhibits the reaction [Ovalbumin results in increased expression of TNF protein] wogonin inhibits the reaction [Cisplatin results in increased expression of TNF protein] wogonin analog results in decreased expression of TNF protein; wogonin results in decreased expression of TNF protein wogonin results in decreased expression of TNF mRNA
|
CTD |
PMID:26213241 PMID:30445784 PMID:31103702 PMID:37004399 PMID:38134066 |
|
NCBI chr20:3,626,685...3,629,303
Ensembl chr20:3,626,532...3,629,303
|
|
G
|
Tp53
|
tumor protein p53
|
increases expression
|
ISO
|
wogonin results in increased expression of TP53 protein
|
CTD |
PMID:21457722 |
|
NCBI chr10:54,798,871...54,810,300
Ensembl chr10:54,798,851...54,810,299
|
|
G
|
Txnrd2
|
thioredoxin reductase 2
|
decreases expression
|
ISO
|
wogonin results in decreased expression of TXNRD2 mRNA; wogonin results in decreased expression of TXNRD2 protein
|
CTD |
PMID:32671444 |
|
NCBI chr11:82,519,996...82,568,156
Ensembl chr11:96,024,324...96,072,475
|
|
G
|
Tyms
|
thymidylate synthetase
|
multiple interactions increases expression
|
ISO
|
[wogonin co-treated with Fluorouracil] results in increased expression of TYMS mRNA wogonin results in increased expression of TYMS mRNA
|
CTD |
PMID:20570612 |
|
NCBI chr 9:120,760,057...120,776,149
Ensembl chr 9:120,763,386...120,776,097
|
|
G
|
Umps
|
uridine monophosphate synthetase
|
multiple interactions decreases expression
|
ISO
|
Fluorouracil inhibits the reaction [wogonin results in decreased expression of UMPS mRNA]
|
CTD |
PMID:20570612 |
|
NCBI chr11:66,806,107...66,816,520
Ensembl chr11:80,311,214...80,327,828
|
|
G
|
Vegfa
|
vascular endothelial growth factor A
|
decreases expression
|
ISO
|
wogonin results in decreased expression of VEGFA mRNA
|
CTD |
PMID:38134066 |
|
NCBI chr 9:22,452,854...22,468,194
Ensembl chr 9:22,439,392...22,468,194
|
|