RGD DISEASE ONTOLOGY - ANNOTATIONS
RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term: middle cerebral artery infarction
Accession: DOID:3525
browse the term
Definition: NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Synonyms: exact_synonym: Left Middle Cerebral Artery Infarction; MCA Infarction; MCAO; Middle Cerebral Artery Circulation Infarction; Middle Cerebral Artery Embolic Infarction; Middle Cerebral Artery Embolus; Middle Cerebral Artery Occlusion; Middle Cerebral Artery Stroke; Middle Cerebral Artery Syndrome; Middle Cerebral Artery Thrombosis; Middle Cerebral Artery Thrombotic Infarction; cerebral infarction, middle cerebral artery; right middle cerebral artery infarction
broad_synonym: THROMBOTIC STROKE
primary_id: MESH:D020244
xref: EFO:1001045
For additional species annotation, visit the
Alliance of Genome Resources .
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Abcc8
ATP binding cassette subfamily C member 8
treatment
IMP
RGD
PMID:23149556 PMID:24602692
RGD:12790979 , RGD:12791996
NCBI chr 1:96,598,568...96,679,563
Ensembl chr 1:96,598,647...96,679,510
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Ace
angiotensin I converting enzyme
treatment
IMP
RGD
PMID:24471927
RGD:11039026
NCBI chr10:90,910,316...90,930,437
Ensembl chr10:90,910,316...90,931,131
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Ace2
angiotensin converting enzyme 2
IEP
mRNA, protein:increased expression:brain
RGD
PMID:24090950
RGD:9685436
NCBI chr X:30,293,597...30,340,961
Ensembl chr X:30,293,589...30,340,977
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Acvr1
activin A receptor type 1
ISO
RGD
PMID:33345977
RGD:329845521
NCBI chr 3:42,978,558...43,097,892
Ensembl chr 3:42,978,561...43,098,241
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Acvr2b
activin A receptor type 2B
ISO
mRNA:increased expression:brain (mouse)
RGD
PMID:33763412
RGD:329849104
NCBI chr 8:119,138,901...119,178,477
Ensembl chr 8:119,138,812...119,170,458
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Adora1
adenosine A1 receptor
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23437309
NCBI chr13:45,658,872...45,695,821
Ensembl chr13:45,658,872...45,695,801
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Ager
advanced glycosylation end product-specific receptor
IEP ISO
associated with Diabetes Mellitus, Experimental CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25446913 PMID:24211797
RGD:8696008
NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078
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Agt
angiotensinogen
IEP
protein:increased expression:brain, serum
RGD
PMID:24090950
RGD:9685436
NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977
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Aifm1
apoptosis inducing factor, mitochondria associated 1
IEP
protein:altered localization: :
RGD
PMID:15181376
RGD:10047403
NCBI chr X:127,650,223...127,689,356
Ensembl chr X:127,650,226...127,689,256
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Ak1
adenylate kinase 1
IEP
protein:decreased expression:cerebral cortex (rat)
RGD
PMID:16468349
RGD:5508760
NCBI chr 3:15,912,431...15,923,045
Ensembl chr 3:15,912,485...15,923,041
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Alb
albumin
treatment
ISO
RGD
PMID:22227456
RGD:11036100
NCBI chr14:17,607,397...17,622,814
Ensembl chr14:17,607,381...17,622,836
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Alox5
arachidonate 5-lipoxygenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:19309543
NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743
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Ap2b1
adaptor related protein complex 2 subunit beta 1
IEP
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr10:68,099,397...68,205,023
Ensembl chr10:68,099,547...68,205,013
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Apaf1
apoptotic peptidase activating factor 1
treatment
IEP
RGD
PMID:24012531
RGD:13703113
NCBI chr 7:25,494,143...25,579,540
Ensembl chr 7:25,494,609...25,579,540
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Apoe
apolipoprotein E
IDA
RGD
PMID:19623195
RGD:6903926
NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932
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App
amyloid beta precursor protein
treatment
IEP
RGD
PMID:28963051
RGD:13782054
NCBI chr11:24,019,774...24,236,584
Ensembl chr11:24,019,778...24,236,561
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Aqp4
aquaporin 4
treatment
IEP IMP
RGD
PMID:20815926 PMID:33127515
RGD:8695955 , RGD:155646130
NCBI chr18:6,507,903...6,524,558
Ensembl chr18:6,507,903...6,524,856
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Arc
activity-regulated cytoskeleton-associated protein
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr 7:106,555,968...106,559,697
Ensembl chr 7:106,555,785...106,559,378
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Atf3
activating transcription factor 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr13:102,751,278...102,800,520
Ensembl chr13:102,751,321...102,764,631
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Bad
BCL2-associated agonist of cell death
treatment
IDA
RGD
PMID:22200499 PMID:21891976
RGD:10053665 , RGD:10053704
NCBI chr 1:204,133,502...204,142,829
Ensembl chr 1:204,131,501...204,142,823
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Bax
BCL2 associated X, apoptosis regulator
treatment
IEP
RGD
PMID:23143152
RGD:10054501
NCBI chr 1:95,940,001...95,945,407
Ensembl chr 1:95,938,808...95,945,368
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Bcan
brevican
IEP
RGD
PMID:15869933
RGD:9590118
NCBI chr 2:173,454,479...173,467,717
Ensembl chr 2:173,454,482...173,467,460
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Bcl2
BCL2, apoptosis regulator
treatment
IEP
RGD
PMID:23143152
RGD:10054501
NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743 Ensembl chr13:22,684,989...22,853,743
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Bdnf
brain-derived neurotrophic factor
treatment
IEP
RGD
PMID:20417695 PMID:28202057 PMID:35218623
RGD:4891138 , RGD:405878057 , RGD:401960864
NCBI chr 3:96,165,042...96,215,621
Ensembl chr 3:96,165,042...96,215,615
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Becn1
beclin 1
treatment
IMP
RGD
PMID:22108007
RGD:11561900
NCBI chr10:86,231,387...86,246,742
Ensembl chr10:86,231,388...86,246,742
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Bnip3
BCL2 interacting protein 3
IEP
protein:increased expression:brain
RGD
PMID:17379825
RGD:9685412
NCBI chr 1:193,708,164...193,725,348
Ensembl chr 1:193,708,167...193,725,359
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Bnip3l
BCL2 interacting protein 3 like
IEP
RGD
PMID:15902200 PMID:21029239
RGD:2314138 , RGD:9068917
NCBI chr15:41,174,594...41,197,730
Ensembl chr15:41,174,594...41,197,803
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C1qtnf6
C1q and TNF related 6
ameliorates
IEP
RGD
PMID:35322553
RGD:242905190
NCBI chr 7:110,077,867...110,084,584
Ensembl chr 7:110,077,878...110,084,412
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C3
complement C3
IEP ISO
protein:increased expression:plasma CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:23199288 PMID:22103620
RGD:7175514
NCBI chr 9:2,087,437...2,114,366
Ensembl chr 9:2,087,437...2,114,429
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Calca
calcitonin-related polypeptide alpha
treatment
IEP
RGD
PMID:30531687
RGD:329849008
NCBI chr 1:168,878,212...168,883,176
Ensembl chr 1:168,878,214...168,883,105
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Camk2a
calcium/calmodulin-dependent protein kinase II alpha
IEP
RGD
PMID:14688616
RGD:1358416
NCBI chr18:54,378,642...54,441,120
Ensembl chr18:54,378,784...54,438,994
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Casp3
caspase 3
treatment
IDA IEP
RGD
PMID:21891976 PMID:26868427 PMID:23143152
RGD:10053704 , RGD:13782346 , RGD:10054501
NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648
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Casp6
caspase 6
IEP
RGD
PMID:26868427
RGD:13782346
NCBI chr 2:218,466,063...218,478,503
Ensembl chr 2:218,466,076...218,478,502
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Casp9
caspase 9
treatment
IEP
RGD
PMID:26868427
RGD:13782346
NCBI chr 5:154,108,872...154,126,628
Ensembl chr 5:154,109,046...154,126,626
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Ccl2
C-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism|therapeutic
CTD
PMID:12374626 PMID:23043544 PMID:25257527
NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226
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Ccl7
C-C motif chemokine ligand 7
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr10:67,016,446...67,018,296
Ensembl chr10:67,016,446...67,018,303
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Cd36
CD36 molecule
treatment
ISO
RGD
PMID:25216018
RGD:11041113
NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903
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Cd86
CD86 molecule
IEP
protein:increased expression:brain subventricular zone, microglial cell (rat)
RGD
PMID:19053043
RGD:2313025
NCBI chr11:64,142,193...64,200,816
Ensembl chr11:64,163,828...64,200,818
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Cdk5
cyclin-dependent kinase 5
ISO
RGD
PMID:24920629
RGD:13782375
NCBI chr 4:10,754,682...10,760,110
Ensembl chr 4:10,754,687...10,760,112
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Cldn5
claudin 5
treatment
IEP
RGD
PMID:24842554
RGD:13204729
NCBI chr11:82,212,822...82,214,248
Ensembl chr11:82,211,475...82,214,992
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Creb1
cAMP responsive element binding protein 1
treatment
IDA
RGD
PMID:35218623
RGD:401960864
NCBI chr 9:65,903,511...65,972,562
Ensembl chr 9:65,903,547...65,970,816
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Crh
corticotropin releasing hormone
IEP
protein:decreased expression:median eminence of hypothalamus (rat)
RGD
PMID:21741032
RGD:5490538
NCBI chr 2:102,143,055...102,144,919
Ensembl chr 2:102,143,055...102,144,919
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Crp
C-reactive protein
ISO
RGD
PMID:15545914
RGD:9585995
NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178
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Crtc1
CREB regulated transcription coactivator 1
treatment
IEP
RGD
PMID:20417695
RGD:4891138
NCBI chr16:18,988,197...19,046,914
Ensembl chr16:18,988,250...19,043,381
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Csf3
colony stimulating factor 3
treatment
ISO IEP
mRNA, protein:increased expression:brain:
RGD
PMID:19298757 PMID:15530654
RGD:11039420 , RGD:11039425
NCBI chr10:83,660,787...83,664,569
Ensembl chr10:83,661,207...83,663,603
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Cxcl10
C-X-C motif chemokine ligand 10
ISO
RGD
PMID:10825390
RGD:632989
NCBI chr14:15,704,772...15,706,969
Ensembl chr14:15,704,758...15,706,975
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Cxcl2
C-X-C motif chemokine ligand 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr14:17,181,030...17,183,075
Ensembl chr14:17,181,062...17,183,075
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Cxcr2
C-X-C motif chemokine receptor 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 9:75,729,493...75,735,868
Ensembl chr 9:75,729,115...75,739,425
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Cxcr3
C-X-C motif chemokine receptor 3
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:10825390
RGD:632989
NCBI chr X:66,844,318...66,846,969
Ensembl chr X:66,844,318...66,846,969
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Cyp2e1
cytochrome P450, family 2, subfamily e, polypeptide 1
IEP
RGD
PMID:23002367
RGD:14700877
NCBI chr 1:195,840,330...195,850,728
Ensembl chr 1:195,840,058...195,864,023
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Dicer1
dicer 1 ribonuclease III
IEP
mRNA:decreased expression:brain:
RGD
PMID:26294080
RGD:11553310
NCBI chr 6:123,627,529...123,692,278
Ensembl chr 6:123,631,250...123,693,965
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Dnmt1
DNA methyltransferase 1
ISO
RGD
PMID:11726790
RGD:9588643
NCBI chr 8:19,440,611...19,486,659
Ensembl chr 8:19,440,611...19,486,659
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Dnmt3a
DNA methyltransferase 3 alpha
IMP
RGD
PMID:23516428
RGD:9589049
NCBI chr 6:26,791,517...26,902,161
Ensembl chr 6:26,822,609...26,896,687
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Dynll1
dynein light chain LC8-type 1
IEP
RGD
PMID:9522364
RGD:13208524
NCBI chr12:41,312,365...41,316,157
Ensembl chr12:41,312,367...41,314,741
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Edn1
endothelin 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:17197033
NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885
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Egr1
early growth response 1
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr18:26,462,967...26,466,766
Ensembl chr18:26,462,981...26,466,766
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Egr2
early growth response 2
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr20:21,051,270...21,056,322
Ensembl chr20:21,051,277...21,055,562
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Egr4
early growth response 4
IEP
RGD
PMID:22645329
RGD:10395314
NCBI chr 4:118,047,869...118,050,328
Ensembl chr 4:118,047,869...118,050,328
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Eif2s1
eukaryotic translation initiation factor 2 subunit alpha
treatment
IDA IMP
RGD
PMID:23669639 PMID:19763736
RGD:10395346 , RGD:10755569
NCBI chr 6:97,672,829...97,697,499
Ensembl chr 6:97,672,766...97,706,225
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Elane
elastase, neutrophil expressed
treatment
IMP
RGD
PMID:10700596
RGD:10450546
NCBI chr 7:9,817,251...9,819,174
Ensembl chr 7:9,817,252...9,819,100
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Eng
endoglin
ISO
RGD
PMID:24876084
RGD:11041171
NCBI chr 3:15,934,566...15,972,618
Ensembl chr 3:15,934,518...15,973,230
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Epcam
epithelial cell adhesion molecule
IEP
RGD
PMID:15950761
RGD:11038820
NCBI chr 6:6,880,142...6,896,103
Ensembl chr 6:6,878,237...6,896,127
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Ephb2
Eph receptor B2
treatment
IEP ISO
mRNA,protein:increased expression: cortex, cerebral cortex subventricular zone
RGD
PMID:16321245 PMID:16321245
RGD:1642069 , RGD:1642069
NCBI chr 5:148,889,574...149,077,027
Ensembl chr 5:148,897,246...149,077,059
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Epn1
Epsin 1
IEP
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr 1:68,742,491...68,760,570
Ensembl chr 1:68,742,789...68,758,874
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Epo
erythropoietin
treatment
ISO
RGD
PMID:20833153 PMID:20547143
RGD:10400898 , RGD:10401066
NCBI chr12:19,204,258...19,207,948
Ensembl chr12:19,204,508...19,207,946
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Ercc6
ERCC excision repair 6, chromatin remodeling factor
IEP
RGD
PMID:9974119
RGD:10401103
NCBI chr16:7,764,983...7,835,587
Ensembl chr16:7,765,013...7,835,587
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F11
coagulation factor XI
ISO
RGD
PMID:16533887
RGD:11041786
NCBI chr16:46,987,988...47,009,015
Ensembl chr16:46,986,107...47,008,437
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F12
coagulation factor XII
treatment
ISO
RGD
PMID:16533887 PMID:16533887
RGD:11041786 , RGD:11041786
NCBI chr17:9,207,683...9,215,530
Ensembl chr17:9,207,683...9,215,530
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F2
coagulation factor II, thrombin
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:29651748
NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486
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Fadd
Fas associated via death domain
treatment
ISO IEP
RGD
PMID:18950622 PMID:23378241
RGD:11341807 , RGD:11344885
NCBI chr 1:199,743,200...199,745,746
Ensembl chr 1:199,739,994...199,745,653
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Fgf2
fibroblast growth factor 2
treatment
IEP
RGD
PMID:30531687
RGD:329849008
NCBI chr 2:120,236,328...120,290,673
Ensembl chr 2:120,236,328...120,291,221
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Fgf21
fibroblast growth factor 21
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454
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Fos
Fos proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 6:105,121,170...105,124,036
Ensembl chr 6:105,121,170...105,124,036
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Gabra6
gamma-aminobutyric acid type A receptor subunit alpha6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr10:26,810,411...26,825,768
Ensembl chr10:26,810,423...26,825,769
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Gap43
growth associated protein 43
treatment
IEP
RGD
PMID:30531687
RGD:329849008
NCBI chr11:58,376,371...58,470,047
Ensembl chr11:58,376,371...58,470,045
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Gapdh
glyceraldehyde-3-phosphate dehydrogenase
IDA
RGD
PMID:25882840
RGD:13792686
NCBI chr 4:157,962,312...157,967,158
Ensembl chr 4:157,962,343...157,966,235
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Gch1
GTP cyclohydrolase 1
treatment
IEP
RGD
PMID:24956890
RGD:401717568
NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698
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Gdnf
glial cell derived neurotrophic factor
treatment
IMP IEP IDA
RGD
PMID:29497380 PMID:28202057 PMID:20468049 PMID:21347705
RGD:40925919 , RGD:405878057 , RGD:405866363 , RGD:405866359
NCBI chr 2:56,894,022...56,919,935
Ensembl chr 2:56,895,010...56,917,209
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Ghrl
ghrelin and obestatin prepropeptide
treatment
IDA
RGD
PMID:19352052
RGD:9850083
NCBI chr 4:146,865,712...146,869,621
Ensembl chr 4:146,865,712...146,869,621
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Ghsr
growth hormone secretagogue receptor
IMP
RGD
PMID:19352052
RGD:9850083
NCBI chr 2:110,268,489...110,271,865
Ensembl chr 2:110,268,489...110,271,865
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Glul
glutamate-ammonia ligase
treatment
IEP
protein:increased expression:eye protein:increased expression:cerebrum, astrocyte
RGD
PMID:24518488 PMID:23595285 PMID:26024074 PMID:26093193
RGD:401794420 , RGD:401794586 , RGD:401794592 , RGD:401794587
NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108
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Grin1
glutamate ionotropic receptor NMDA type subunit 1
treatment
IEP
RGD
PMID:26674869
RGD:11068571
NCBI chr 3:8,103,680...8,130,603
Ensembl chr 3:8,103,680...8,130,603
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Grn
granulin precursor
treatment
ISO
RGD
PMID:23972823
RGD:10401661
NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775
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Grpel1
GrpE-like 1, mitochondrial
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:12505684
RGD:632868
NCBI chr14:74,292,023...74,298,243
Ensembl chr14:74,292,023...74,298,200
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Gsk3b
glycogen synthase kinase 3 beta
treatment
IDA
RGD
PMID:28440874
RGD:13792734
NCBI chr11:62,498,997...62,648,665
Ensembl chr11:62,504,316...62,648,646
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Gsn
gelsolin
ameliorates
ISO
RGD
PMID:18234195 PMID:9927495
RGD:329333031 , RGD:329333033
NCBI chr 3:18,585,166...18,638,404
Ensembl chr 3:18,585,172...18,638,402
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H19
H19 imprinted maternally expressed transcript
ameliorates
IEP ISO IMP
RNA:increased expression:brain (rat) RNA:increased expression:brain (mouse)
RGD
PMID:28203482 PMID:28630232 PMID:35322553 PMID:31170091 PMID:32335212
RGD:155900760 , RGD:242905192 , RGD:242905190 , RGD:242905188 , RGD:156451661
NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134
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Hamp
hepcidin antimicrobial peptide
IEP
mRNA, protein:increased expression:cerebral cortex, hippocampus, corpus striatum
RGD
PMID:21957487
RGD:11041635
NCBI chr 1:86,170,926...86,172,865
Ensembl chr 1:86,170,901...86,172,891
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Has2
hyaluronan synthase 2
IEP
mRNA:increased expression:brain
RGD
PMID:11283406
RGD:9588631
NCBI chr 7:88,113,326...88,139,337
Ensembl chr 7:88,113,326...88,128,933
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Hdac2
histone deacetylase 2
exacerbates
ISO
RGD
PMID:32239566
RGD:155883173
NCBI chr20:40,548,244...40,571,609
Ensembl chr20:40,548,250...40,571,609
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Hdac4
histone deacetylase 4
treatment
IEP
mRNA,protein:decreased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164
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Hdac5
histone deacetylase 5
treatment
IEP
mRNA,protein:decreased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr10:87,152,978...87,187,921
Ensembl chr10:87,152,978...87,188,235
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Hdac9
histone deacetylase 9
IEP
mRNA:increased expression:brain:
RGD
PMID:23480850
RGD:9681449
NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333
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Hif1a
hypoxia inducible factor 1 subunit alpha
treatment
IDA
RGD
PMID:21029239
RGD:9068917
NCBI chr 6:92,624,059...92,669,262
Ensembl chr 6:92,624,390...92,669,261
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Hmgb1
high mobility group box 1
treatment
IEP
RGD
PMID:23480850
RGD:9681449
NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565 Ensembl chr16:5,901,586...5,978,565
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Hmox1
heme oxygenase 1
treatment
IEP IDA ISO
RGD
PMID:24252362 PMID:23870531 PMID:20888632
RGD:10755587 , RGD:10755755 , RGD:10755588
NCBI chr19:13,466,287...13,474,082
Ensembl chr19:13,467,244...13,474,079
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Hp
haptoglobin
IEP
RGD
PMID:22103620
RGD:7175514
NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523
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Hspa4
heat shock protein family A (Hsp70) member 4
IMP ISO
rat gene in mouse model
RGD
PMID:17473852 PMID:21709150
RGD:5688754 , RGD:6218961
NCBI chr10:37,408,025...37,449,080
Ensembl chr10:37,408,025...37,449,001
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Hspd1
heat shock protein family D (Hsp60) member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 9:56,579,195...56,590,011
Ensembl chr 9:56,579,201...56,589,662
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Htra2
HtrA serine peptidase 2
IEP ISO
protein:increased expression:brain, cytosol (rat) protein:increased expression:brain, cytosol (mouse)
RGD
PMID:16978742 PMID:15306124
RGD:2314385 , RGD:5688372
NCBI chr 4:115,556,914...115,560,202
Ensembl chr 4:115,556,916...115,560,095
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Hvcn1
hydrogen voltage-gated channel 1
IMP
RGD
PMID:31250553
RGD:14985213
NCBI chr12:34,341,673...34,370,010
Ensembl chr12:34,335,190...34,370,141
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Hvcn1em2Mcwi
hydrogen voltage-gated channel 1; zinc finger nuclease induced mutant 2, Medical College of Wisconsin
IMP
RGD
PMID:31250553
RGD:14985213
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Icam1
intercellular adhesion molecule 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438
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Igf1
insulin-like growth factor 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 7:22,282,895...22,361,972
Ensembl chr 7:22,282,930...22,359,296
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Ikbkb
inhibitor of nuclear factor kappa B kinase subunit beta
treatment
ISO
RGD
PMID:16286924
RGD:10045955
NCBI chr16:69,319,487...69,373,251
Ensembl chr16:69,319,554...69,373,250
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Il10
interleukin 10
ameliorates
ISO
RGD
PMID:28630232
RGD:242905192
NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313
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Il11
interleukin 11
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 1:69,069,829...69,076,129
Ensembl chr 1:69,068,137...69,076,129
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Il13
interleukin 13
IEP
protein:increased expression:cerebral cortex
RGD
PMID:23028794
RGD:7204480
NCBI chr10:37,790,130...37,792,687
Ensembl chr10:37,790,130...37,792,737
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Il1b
interleukin 1 beta
ameliorates treatment
IEP ISO
protein:increased expression:cerebral cortex (rat) CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:25257527 PMID:23028794 PMID:35322553 PMID:29498696 PMID:24916922
RGD:7204480 , RGD:242905190 , RGD:13792833 , RGD:10450594
NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415
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Il1rn
interleukin 1 receptor antagonist
treatment
ISO
human gene in a rat model
RGD
PMID:7790404
RGD:8551708
NCBI chr 3:7,111,567...7,127,451
Ensembl chr 3:7,111,550...7,127,445
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Il22
interleukin 22
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 7:53,801,206...53,805,673
Ensembl chr 7:53,801,206...53,806,186
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Il4
interleukin 4
IEP
protein:increased expression:cerebral cortex
RGD
PMID:23028794
RGD:7204480
NCBI chr10:37,771,203...37,776,750
Ensembl chr10:37,771,203...37,776,750
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Il5
interleukin 5
IEP
RGD
PMID:23028794
RGD:7204480
NCBI chr10:37,874,342...37,877,213
Ensembl chr10:37,874,342...37,877,213
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Il6
interleukin 6
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:12374626 PMID:21940958 PMID:25257527 PMID:29498696
RGD:13792833
NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178
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Il6r
interleukin 6 receptor
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 2:175,289,157...175,347,719
Ensembl chr 2:175,298,686...175,347,536
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Il6st
interleukin 6 cytokine family signal transducer
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 2:44,065,979...44,106,255
Ensembl chr 2:44,066,130...44,109,936
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Il7r
interleukin 7 receptor
IEP
protein:increased expression:brain:
RGD
PMID:30676545
RGD:151347693
NCBI chr 2:58,452,393...58,477,757
Ensembl chr 2:58,454,217...58,477,757
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Ina
internexin neuronal intermediate filament protein, alpha
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr 1:245,896,775...245,908,330
Ensembl chr 1:245,896,775...245,908,330
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Inhba
inhibin subunit beta A
ISO
RGD
PMID:33345977
RGD:329845521
NCBI chr17:49,091,635...49,111,573
Ensembl chr17:49,095,920...49,108,982
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Irf4
interferon regulatory factor 4
IEP
RGD
PMID:25652434
RGD:11530061
NCBI chr17:33,721,800...33,742,570
Ensembl chr17:33,721,811...33,740,070
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Junb
JunB proto-oncogene, AP-1 transcription factor subunit
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr19:23,176,265...23,178,049
Ensembl chr19:23,176,294...23,178,035
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Kcnn4
potassium calcium-activated channel subfamily N member 4
ameliorates
ISO IMP
RGD
PMID:26661208 PMID:25477223 PMID:21750563
RGD:329955572 , RGD:401700383 , RGD:329955444
NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340
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Mag
myelin-associated glycoprotein
treatment
IMP
RGD
PMID:15678116
RGD:9685232
NCBI chr 1:86,148,227...86,163,726
Ensembl chr 1:86,148,228...86,163,656
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Mapk1
mitogen activated protein kinase 1
treatment
IDA
RGD
PMID:27152455 PMID:35218623
RGD:13800881 , RGD:401960864
NCBI chr11:83,957,813...84,023,629
Ensembl chr11:83,957,813...84,023,616
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Mapk3
mitogen activated protein kinase 3
treatment
IDA
RGD
PMID:27152455 PMID:35218623
RGD:13800881 , RGD:401960864
NCBI chr 1:181,366,646...181,372,863
Ensembl chr 1:181,366,637...181,372,863
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Mapt
microtubule-associated protein tau
treatment
IEP IDA ISO
RGD
PMID:28886009 PMID:25903928 PMID:28886009
RGD:13800886 , RGD:13800913 , RGD:13800886
NCBI chr10:89,138,644...89,236,137
Ensembl chr10:89,138,627...89,236,129
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Mir107
microRNA 107
IEP
RNA:increased expression:brain
RGD
PMID:26294080
RGD:11553310
NCBI chr 1:232,337,767...232,337,853
Ensembl chr 1:232,337,767...232,337,853
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Mir132
microRNA 132
treatment
ISO
mRNA:decreased expression:brain (mouse)
RGD
PMID:33763412 PMID:33763412
RGD:329849104 , RGD:329849104
NCBI chr10:60,023,696...60,023,796
Ensembl chr10:60,023,696...60,023,796
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Mir140
microRNA 140
ameliorates
ISO IEP
miRNA:decreased expression:cerebral cortex (rat)
RGD
PMID:33246036 PMID:27035554
RGD:329337375 , RGD:329337377
NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675
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Mir19a
microRNA 19a
ISO
RNA:decreased expression:brain (mouse)
RGD
PMID:32335212
RGD:156451661
NCBI chr15:92,180,912...92,180,993
Ensembl chr15:92,180,912...92,180,993
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Mir210
microRNA 210
treatment
IEP
RGD
PMID:34337881
RGD:155269103
NCBI chr 1:196,326,343...196,326,452
Ensembl chr 1:196,326,337...196,326,454
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Mir29b1
microRNA 29b-1
exacerbates
IMP
RGD
PMID:35322553
RGD:242905190
NCBI chr 4:59,650,987...59,651,067
Ensembl chr 4:59,650,986...59,651,067
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Mir494
microRNA 494
ameliorates
ISO
RGD
PMID:32239566 PMID:31465536
RGD:155883173 , RGD:156430320
NCBI chr 6:128,728,710...128,728,792
Ensembl chr 6:128,728,709...128,728,793
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Mmp9
matrix metallopeptidase 9
treatment
ISO IEP
CTD Direct Evidence: marker/mechanism
CTD RGD
PMID:19309543 PMID:24842554
RGD:13204729
NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120
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Mt3
metallothionein 3
IEP
protein:decreased expression:brain
RGD
PMID:8869568
RGD:9685807
NCBI chr19:10,848,754...10,850,158
Ensembl chr19:10,848,755...10,850,158
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Mtor
mechanistic target of rapamycin kinase
treatment
IEP IDA
RGD
PMID:24583056 PMID:21185267 PMID:23777415
RGD:10040971 , RGD:10041016 , RGD:10040974
NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311
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Nae1
NEDD8 activating enzyme E1 subunit 1
IEP
RGD
PMID:21386696
RGD:13801046
NCBI chr19:446,015...472,145
Ensembl chr19:446,000...472,371
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Nampt
nicotinamide phosphoribosyltransferase
treatment
IMP
RGD
PMID:28495827
RGD:13781880
NCBI chr 6:49,425,316...49,462,109
Ensembl chr 6:49,424,332...49,462,100
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Ncam1
neural cell adhesion molecule 1
treatment
ISO IMP
RGD
PMID:32962079 PMID:29497380
RGD:40924633 , RGD:40925919
NCBI chr 8:49,865,629...50,165,687
Ensembl chr 8:49,865,633...50,166,014
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Nefh
neurofilament heavy chain
ISO
RGD
PMID:29967576
RGD:27226878
NCBI chr14:79,830,362...79,840,347
Ensembl chr14:79,830,362...79,840,351
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Nefl
neurofilament light chain
ISO
protein:increased expression:brain
RGD
PMID:29967576
RGD:27226878
NCBI chr15:42,301,920...42,305,793
Ensembl chr15:42,301,916...42,305,793
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Nefm
neurofilament medium chain
ISO
protein:altered expression:brain
RGD
PMID:29967576
RGD:27226878
NCBI chr15:42,360,449...42,365,753
Ensembl chr15:42,360,454...42,365,755
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Nfe2l2
NFE2 like bZIP transcription factor 2
treatment
IDA
RGD
PMID:23880501 PMID:24466583
RGD:10412696 , RGD:10412714
NCBI chr 3:60,594,239...60,621,712
Ensembl chr 3:60,594,242...60,621,737
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Nfkbia
NFKB inhibitor alpha
treatment
IEP
RGD
PMID:21122797
RGD:10413868
NCBI chr 6:72,858,713...72,861,941
Ensembl chr 6:72,858,712...72,861,941
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Ngf
nerve growth factor
treatment
ISO IMP
CTD Direct Evidence: therapeutic
CTD RGD
PMID:10408807 PMID:29409115
RGD:402463967
NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452
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Ngfr
nerve growth factor receptor
treatment
IDA
RGD
PMID:22678884
RGD:10413900
NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518
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Nod2
nucleotide-binding oligomerization domain containing 2
treatment
IEP
RGD
PMID:24842554
RGD:13204729
NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177
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Nos2
nitric oxide synthase 2
IEP ISO
protein:increased expression:brain (rat) mRNA:increased expression:brain (mouse)
RGD
PMID:21959178 PMID:22020035
RGD:5508751 , RGD:5509037
NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210
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Nox1
NADPH oxidase 1
treatment
IEP
RGD
PMID:30816157
RGD:329955567
NCBI chr X:97,279,058...97,332,291
Ensembl chr X:97,279,056...97,302,236
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Nqo1
NAD(P)H quinone dehydrogenase 1
treatment
IEP
protein:increased expression:brain
RGD
PMID:21120604 PMID:25069640
RGD:5133239 , RGD:11035212
NCBI chr19:35,295,633...35,310,528
Ensembl chr19:35,295,573...35,310,557
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Nrg1
neuregulin 1
treatment ameliorates
ISO
RGD
PMID:20691195 PMID:30206770
RGD:10449015 , RGD:405650589
NCBI chr16:59,250,658...60,304,519
Ensembl chr16:59,250,854...60,296,884
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Ogg1
8-oxoguanine DNA glycosylase
treatment
IEP
associated with Hypertension
RGD
PMID:17920569
RGD:8657395
NCBI chr 4:146,474,701...146,481,959
Ensembl chr 4:146,474,750...146,484,766
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Park7
Parkinsonism associated deglycase
treatment
ISO
RGD
PMID:17882163
RGD:13463450
NCBI chr 5:161,353,718...161,376,993
Ensembl chr 5:161,353,719...161,376,970
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Parp1
poly (ADP-ribose) polymerase 1
treatment
ISO IDA IEP
RGD
PMID:21311064 PMID:25882840 PMID:23143152 PMID:23801245
RGD:5683909 , RGD:13792686 , RGD:10054501 , RGD:11073732
NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404
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Pawr
pro-apoptotic WT1 regulator
treatment
ISO IEP
protein:increased expression:brain:
RGD
PMID:16403464 PMID:19352052 PMID:11323519
RGD:9835380 , RGD:9850083 , RGD:9835381
NCBI chr 7:43,645,028...43,725,033
Ensembl chr 7:43,645,084...43,725,028
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Pdgfra
platelet derived growth factor receptor alpha
treatment
IDA
RGD
PMID:16917016
RGD:11084934
NCBI chr14:33,005,838...33,054,347
Ensembl chr14:33,005,839...33,054,335
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Pdgfrb
platelet derived growth factor receptor beta
treatment
IDA
RGD
PMID:16917016
RGD:11084934
NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843
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Plat
plasminogen activator, tissue type
IEP ISO
CTD Direct Evidence: therapeutic
CTD RGD
PMID:12297567 PMID:17690543 PMID:18453163 PMID:20547619 PMID:29651748 PMID:14512838 More...
RGD:1580876
NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223
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Plau
plasminogen activator, urokinase
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:11677890 PMID:15181847 PMID:17702958
NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775
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Pld1
phospholipase D1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 2:110,849,205...111,047,304
Ensembl chr 2:110,893,608...111,047,692
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Prkcg
protein kinase C, gamma
ISO
RGD
PMID:14688616
RGD:1358416
NCBI chr 1:65,832,851...65,860,676
Ensembl chr 1:65,832,855...65,859,384
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Proc
protein C, inactivator of coagulation factors Va and VIIIa
treatment
ISO
RGD
PMID:24159062
RGD:11100027
NCBI chr18:23,764,367...23,774,816
Ensembl chr18:23,764,368...23,775,133
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Ptprz1
protein tyrosine phosphatase, receptor type Z1
IEP
mRNA:increased expression:cerebral cortex
RGD
PMID:15869933
RGD:9590118
NCBI chr 4:51,397,316...51,595,220
Ensembl chr 4:51,397,601...51,595,218
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Rbfox3
RNA binding fox-1 homolog 3
treatment
IEP
RGD
PMID:30531687
RGD:329849008
NCBI chr10:103,720,355...104,157,277
Ensembl chr10:103,720,636...104,156,935
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Reln
reelin
severity
ISO
RGD
PMID:16438965
RGD:13207538
NCBI chr 4:12,736,177...13,162,956
Ensembl chr 4:12,736,130...13,162,211
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Rgma
repulsive guidance molecule BMP co-receptor a
treatment
IEP IMP
RGD
PMID:21840379 PMID:23275173
RGD:9850121 , RGD:9850122
NCBI chr 1:127,128,934...127,172,918
Ensembl chr 1:127,128,934...127,172,918
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Rpl28
ribosomal protein L28
IEP
RGD
PMID:16805800
RGD:6480229
NCBI chr 1:69,052,148...69,054,735
Ensembl chr 1:69,053,203...69,055,032
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Runx1
RUNX family transcription factor 1
IAGP
mRNA:increased expression:brain
RGD
PMID:24672479
RGD:11251714
NCBI chr11:31,839,880...32,074,427
Ensembl chr11:31,843,764...32,074,542
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S100a5
S100 calcium binding protein A5
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:25257527
NCBI chr 2:176,095,332...176,099,546
Ensembl chr 2:176,097,539...176,099,546
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S100b
S100 calcium binding protein B
IEP
protein:increased expression:cerebrum, astrocyte
RGD
PMID:23595285
RGD:401794586
NCBI chr20:12,372,866...12,381,619
Ensembl chr20:12,372,881...12,394,743
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Serpine1
serpin family E member 1
IEP
RGD
PMID:14512838
RGD:1580876
NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657
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Serpinf1
serpin family F member 1
treatment
IDA
RGD
PMID:22714093
RGD:8655545
NCBI chr10:60,250,198...60,262,593
Ensembl chr10:60,249,708...60,262,646
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Serpinh1
serpin family H member 1
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 1:153,643,500...153,650,853
Ensembl chr 1:153,643,510...153,650,801
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Shh
sonic hedgehog signaling molecule
treatment
ISO
RGD
PMID:22324418
RGD:12879461
NCBI chr 4:6,954,017...6,963,170
Ensembl chr 4:6,954,017...6,963,170
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Sirt1
sirtuin 1
treatment
IMP ISO
RGD
PMID:23600725 PMID:23600725
RGD:9585664 , RGD:9585664
NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260
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Slc12a2
solute carrier family 12 member 2
treatment
IMP ISO
protein:increased expression:brain:
RGD
PMID:12535773 PMID:27798271
RGD:1580583 , RGD:14398833
NCBI chr18:51,348,282...51,416,448
Ensembl chr18:51,348,302...51,416,440
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Slc1a2
solute carrier family 1 member 2
treatment
IEP
RGD
PMID:20423712
RGD:401794585
NCBI chr 3:89,005,129...89,135,469
Ensembl chr 3:89,005,129...89,126,498
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Slc2a1
solute carrier family 2 member 1
treatment
IEP
RGD
PMID:9419067
RGD:12879855
NCBI chr 5:132,717,196...132,745,416
Ensembl chr 5:132,717,196...132,745,416
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Slc9a1
solute carrier family 9 member A1
treatment
IMP
RGD
PMID:31250553
RGD:14985213
NCBI chr 5:145,576,341...145,629,630
Ensembl chr 5:145,576,334...145,629,624
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Slpi
secretory leukocyte peptidase inhibitor
treatment
IEP
RGD
PMID:14500739
RGD:9999390
NCBI chr 3:153,082,208...153,084,457
Ensembl chr 3:153,082,369...153,084,453
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Smo
smoothened, frizzled class receptor
treatment
IMP
RGD
PMID:23696546 PMID:23499832
RGD:12832759 , RGD:12879404
NCBI chr 4:58,343,626...58,373,823
Ensembl chr 4:58,343,529...58,373,829
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Smox
spermine oxidase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:30576531
NCBI chr 3:118,731,814...118,767,242
Ensembl chr 3:118,731,900...118,765,710
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Snap91
synaptosome associated protein 91
IEP
protein:increased degradation:brain
RGD
PMID:19240038
RGD:13461853
NCBI chr 8:87,738,056...87,852,690
Ensembl chr 8:87,738,824...87,852,367
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Sod1
superoxide dismutase 1
treatment
IDA IEP
mRNA, protein:increased expression:cerebral cortex (rat)
RGD
PMID:22001340 PMID:22133807
RGD:8657021 , RGD:8657023
NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249
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Sod2
superoxide dismutase 2
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189
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Sphk2
sphingosine kinase 2
ISO
CTD Direct Evidence: therapeutic
CTD
PMID:23043544
NCBI chr 1:96,180,872...96,188,592
Ensembl chr 1:96,180,887...96,188,391
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Stat3
signal transducer and activator of transcription 3
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:21940958
NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057
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Tgfb1
transforming growth factor, beta 1
ameliorates
IEP ISO
RGD
PMID:31409163 PMID:28630232
RGD:14995477 , RGD:242905192
NCBI chr 1:81,196,532...81,212,848
Ensembl chr 1:81,196,532...81,212,847
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Th
tyrosine hydroxylase
IEP
protein:decreased expression:substantia nigra pars compacta, neuron (rat)
RGD
PMID:21366664
RGD:5128609
NCBI chr 1:198,071,500...198,078,832
Ensembl chr 1:198,071,503...198,109,767
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Tnf
tumor necrosis factor
treatment ameliorates
IEP ISO IMP
RGD
PMID:24916922 PMID:28630232 PMID:35322553 PMID:15647744 PMID:29498696
RGD:10450594 , RGD:242905192 , RGD:242905190 , RGD:13825261 , RGD:13792833
NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629
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Tnfaip6
TNF alpha induced protein 6
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 3:36,502,250...36,521,652
Ensembl chr 3:36,502,188...36,521,649
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Tnfrsf1a
TNF receptor superfamily member 1A
IMP
RGD
PMID:15647744
RGD:13825261
NCBI chr 4:158,150,815...158,163,592
Ensembl chr 4:158,150,820...158,163,591
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Trem1
triggering receptor expressed on myeloid cells 1
ameliorates
IDA
RGD
PMID:32736673
RGD:127284860
NCBI chr 9:12,763,819...12,779,285
Ensembl chr 9:12,763,819...12,779,203
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Upp1
uridine phosphorylase 1
IEP
mRNA, protein:increased expression:brain (rat)
RGD
PMID:18457515
RGD:2317094
NCBI chr14:83,809,495...83,829,299
Ensembl chr14:83,809,960...83,829,462
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Vegfa
vascular endothelial growth factor A
treatment
IMP IEP
mRNA,protein:increased expression:cerebral cortex (rat)
RGD
PMID:29497380 PMID:30531687 PMID:27035554
RGD:40925919 , RGD:329849008 , RGD:329337377
NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641
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Xdh
xanthine dehydrogenase
ISO
CTD Direct Evidence: marker/mechanism
CTD
PMID:12374626
NCBI chr 6:21,530,463...21,592,172
Ensembl chr 6:21,530,113...21,592,268
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