RGD Reference Report - Focal transient ischemia increases APP-BP1 expression in neural progenitor cells. - Rat Genome Database
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Focal transient ischemia increases APP-BP1 expression in neural progenitor cells.

Authors: Joo, Yuyoung  Lee, Sang Hyung  Ha, Sungji  Hong, Bo-Hyun  Kim, Joung-Hun  Suh, Yoo-Hun  Kim, Hye-Sun 
Citation: Joo Y, etal., Neuroreport. 2011 Mar 30;22(5):200-5. doi: 10.1097/WNR.0b013e32834449cf.
RGD ID: 13801046
Pubmed: (View Article at PubMed) PMID:21386696
DOI: Full-text: DOI:10.1097/WNR.0b013e32834449cf

Amyloid precursor protein binding protein-1 (APP-BP1) binds to the carboxyl terminus of APP. In this study, we explored whether APP-BP1 expression is affected by focal transient cerebral ischemia induced by middle cerebral artery occlusion in Wistar rats. APP-BP1 expression was increased in the dentate gyrus of the hippocampus and in the subventricular zone of rats exposed to focal transient cerebral ischemia. In addition, APP-BP1 immunoreactivity overlapped with antidoublecortin and anti-5-bromo-2-deoxyuridine labeling. Focal transient cerebral ischemia has been reported earlier to induce neurogenesis in adult brains. The upregulation of APP-BP1 expression in neural progenitor cells after focal transient ischemia suggests that this protein contributes to the neurogenesis induced by transient ischemia and reperfusion.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Nae1  (NEDD8 activating enzyme E1 subunit 1)

Genes (Mus musculus)
Nae1  (NEDD8 activating enzyme E1 subunit 1)

Genes (Homo sapiens)
NAE1  (NEDD8 activating enzyme E1 subunit 1)


Additional Information