RGD Reference Report - 4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action. - Rat Genome Database
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4-hydroxybenzyl alcohol ameliorates cerebral injury in rats by antioxidant action.

Authors: Yu, SS  Zhao, J  Lei, SP  Lin, XM  Wang, LL  Zhao, Y 
Citation: Yu SS, etal., Neurochem Res. 2011 Feb;36(2):339-46. Epub 2010 Dec 1.
RGD ID: 5133239
Pubmed: (View Article at PubMed) PMID:21120604
DOI: Full-text: DOI:10.1007/s11064-010-0335-8

4-hydroxybenzyl alcohol (4-HBA), one of the phenolic constituents found in many herbal medicinal plants, exhibits beneficial effects in neurological disorders. In the present study, we evaluated 4-HBA's role in transient cerebral ischemia and its potential mechanism. Pre-treatment with 4-HBA (50,100 mg/kg) significantly reduced the cerebral infarct size and improved the neurological symptoms. Morphological examinations showed 4-HBA reduced the number of degenerated neurons. Oxidative stress was evaluated superoxide dismutase (SOD) activity and malondialdehyde (MDA) level. Anti-oxidative mechanisms were studied by Immunofluorescence staining and western immunoblot analysis. 4-HBA increased the expression of NAD(P)H: quinone oxidoreductase1 (NQO1) and ultimately inhibited oxidative stress. In addition, we evaluated the time course expression of NQO1, which was upregulated in the ischemic brain beginning at 1 h. Taken together, these results suggested that 4-HBA ameliorated cerebral injury in rats, This neuroprotective effect is likely related to its antioxidant activities.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Nqo1  (NAD(P)H quinone dehydrogenase 1)

Genes (Mus musculus)
Nqo1  (NAD(P)H dehydrogenase, quinone 1)

Genes (Homo sapiens)
NQO1  (NAD(P)H quinone dehydrogenase 1)


Additional Information