RGD Reference Report - Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke. - Rat Genome Database

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Expression of interleukin-9 and its upstream stimulating factors in rats with ischemic stroke.

Authors: Lin, Y  Zhang, L  Dai, Y  Li, H  Wang, Y  Zhang, B  Chen, S  Lu, Z 
Citation: Lin Y, etal., Neurol Sci. 2015 Jun;36(6):913-20. doi: 10.1007/s10072-015-2096-2. Epub 2015 Feb 5.
RGD ID: 11530061
Pubmed: PMID:25652434   (View Abstract at PubMed)
DOI: DOI:10.1007/s10072-015-2096-2   (Journal Full-text)

To investigate the temporal expressions of IL-9 and its related cytokines after middle cerebral artery occlusion in rats. IL-9 and its related cytokines in ischemia brain and blood were tested after rats were subjected to transient focal ischemia. Comparing with sham-operated group, the levels of IL-4, TGF-beta, PU.1, IRF4, OX40, NIK, RelB-p52 and IL-9 in experimental groups were significantly higher after middle cerebral artery occlusion. The results showed that expressions of IL-9 and its upstream stimulating factors increased in experimental stroke, and whether they play a role or just a secondary change is awaiting further research.

RGD Manual Disease Annotations    Click to see Annotation Detail View
TermQualifierEvidenceWithReferenceNotesSourceOriginal Reference(s)
middle cerebral artery infarction  ISOIrf4 (Rattus norvegicus)11530061; 11530061 RGD 
middle cerebral artery infarction  IEP 11530061 RGD 

Objects Annotated

Genes (Rattus norvegicus)
Irf4  (interferon regulatory factor 4)

Genes (Mus musculus)
Irf4  (interferon regulatory factor 4)

Genes (Homo sapiens)
IRF4  (interferon regulatory factor 4)


Additional Information