RGD Reference Report - Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury. - Rat Genome Database
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Eriodictyol-7-O-glucoside activates Nrf2 and protects against cerebral ischemic injury.

Authors: Jing, X  Ren, D  Wei, X  Shi, H  Zhang, X  Perez, RG  Lou, H  Lou, H 
Citation: Jing X, etal., Toxicol Appl Pharmacol. 2013 Dec 15;273(3):672-9.
RGD ID: 10412714
Pubmed: (View Article at PubMed) PMID:24466583

Stroke is a complex disease that may involve oxidative stress-related pathways in its pathogenesis. The nuclear factor erythroid-2-related factor 2/antioxidant response element (Nrf2/ARE) pathway plays an important role in inducing phase II detoxifying enzymes and antioxidant proteins and thus has been considered a potential target for neuroprotection in stroke. The aim of the present study was to determine whether eriodictyol-7-O-glucoside (E7G), a novel Nrf2 activator, can protect against cerebral ischemic injury and to understand the role of the Nrf2/ARE pathway in neuroprotection. In primary cultured astrocytes, E7G increased the nuclear localization of Nrf2 and induced the expression of the Nrf2/ARE-dependent genes. Exposure of astrocytes to E7G provided protection against oxygen and glucose deprivation (OGD)-induced oxidative insult. The protective effect of E7G was abolished by RNA interference-mediated knockdown of Nrf2 expression. In vivo administration of E7G in a rat model of focal cerebral ischemia significantly reduced the amount of brain damage and ameliorated neurological deficits. These data demonstrate that activation of Nrf2/ARE signaling by E7G is directly associated with its neuroprotection against oxidative stress-induced ischemic injury and suggest that targeting the Nrf2/ARE pathway may be a promising approach for therapeutic intervention in stroke.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Nfe2l2  (nuclear factor, erythroid 2-like 2)

Genes (Mus musculus)
Nfe2l2  (nuclear factor, erythroid derived 2, like 2)

Genes (Homo sapiens)
NFE2L2  (nuclear factor, erythroid 2 like 2)


Additional Information