Mir494 (microRNA 494) - Rat Genome Database

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Gene: Mir494 (microRNA 494) Rattus norvegicus
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Symbol: Mir494
Name: microRNA 494
RGD ID: 2325523
Description: Predicted to enable mRNA base-pairing translational repressor activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cytokine production; and negative regulation of non-canonical NF-kappaB signal transduction. Used to study epilepsy. Human ortholog(s) of this gene implicated in cholangiocarcinoma; head and neck squamous cell carcinoma; osteosarcoma; pancreatic ductal adenocarcinoma; and urinary bladder cancer. Orthologous to human MIR494 (microRNA 494); INTERACTS WITH bis(2-ethylhexyl) phthalate; bleomycin A2; cadmium dichloride.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: microRNA mir-494; rno-mir-494
RGD Orthologs
Human
Mouse
Dog
Alliance Orthologs
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,550,115 - 134,550,197 (+)NCBIGRCr8
mRatBN7.26128,728,710 - 128,728,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,728,709 - 128,728,793 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,907,952 - 128,908,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,203,784 - 129,203,866 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,565,401 - 128,565,483 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,864,370 - 133,864,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,864,369 - 133,864,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,026,541 - 143,026,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,313,091 - 126,313,173 (+)NCBICelera
Cytogenetic Map6q32NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


References

References - curated
# Reference Title Reference Citation
1. Activation of microRNA-494-targeting Bmi1 and ADAM10 by silibinin ablates cancer stemness and predicts favourable prognostic value in head and neck squamous cell carcinomas. Chang YC, etal., Oncotarget. 2015 Sep 15;6(27):24002-16.
2. MicroRNA-494 is a master epigenetic regulator of multiple invasion-suppressor microRNAs by targeting ten eleven translocation 1 in invasive human hepatocellular carcinoma tumors. Chuang KH, etal., Hepatology. 2015 Aug;62(2):466-80. doi: 10.1002/hep.27816. Epub 2015 May 6.
3. MicroRNA-494 represses osteosarcoma development by modulating ASK-1 related apoptosis complexes. Gao G and Jian Y, Transl Cancer Res. 2020 Jul;9(7):4121-4130. doi: 10.21037/tcr-19-2195.
4. MicroRNA-494 targets PTEN and suppresses PI3K/AKT pathway to alleviate hypertrophic scar formation. He T, etal., J Mol Histol. 2019 Aug;50(4):315-323. doi: 10.1007/s10735-019-09828-w. Epub 2019 May 8.
5. MicroRNA-494 reduces ATF3 expression and promotes AKI. Lan YF, etal., J Am Soc Nephrol. 2012 Dec;23(12):2012-23. doi: 10.1681/ASN.2012050438. Epub 2012 Nov 15.
6. Intravenous antagomiR-494 lessens brain-infiltrating neutrophils by increasing HDAC2-mediated repression of multiple MMPs in experimental stroke. Li F, etal., FASEB J. 2020 May;34(5):6934-6949. doi: 10.1096/fj.201903127R. Epub 2020 Apr 2.
7. Down-regulation of microRNA-494 via loss of SMAD4 increases FOXM1 and β-catenin signaling in pancreatic ductal adenocarcinoma cells. Li L, etal., Gastroenterology. 2014 Aug;147(2):485-97.e18. doi: 10.1053/j.gastro.2014.04.048. Epub 2014 May 20.
8. MicroRNA-494-dependent WDHDI inhibition suppresses epithelial-mesenchymal transition, tumor growth and metastasis in cholangiocarcinoma. Liu B, etal., Dig Liver Dis. 2019 Mar;51(3):397-411. doi: 10.1016/j.dld.2018.08.021. Epub 2018 Aug 30.
9. TGF-β Enhances the Anti-inflammatory Effect of Tumor- Infiltrating CD33+11b+HLA-DR Myeloid-Derived Suppressor Cells in Gastric Cancer: A Possible Relation to MicroRNA-494. Moaaz M, etal., Asian Pac J Cancer Prev. 2020 Nov 1;21(11):3393-3403. doi: 10.31557/APJCP.2020.21.11.3393.
10. Overexpressed microRNA-494 represses RIPK1 to attenuate hippocampal neuron injury in epilepsy rats by inactivating the NF-κB signaling pathway. Qi Y, etal., Cell Cycle. 2020 Jun;19(11):1298-1313. doi: 10.1080/15384101.2020.1749472. Epub 2020 Apr 19.
11. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
12. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
13. Downregulation of MicroRNA-494 inhibits the TGF-β1/Smads signaling pathway and prevents the development of hypospadias through upregulating Nedd4L. Tian RH, etal., Exp Mol Pathol. 2020 Aug;115:104452. doi: 10.1016/j.yexmp.2020.104452. Epub 2020 May 13.
14. MicroRNA-494-3p alleviates inflammatory response in sepsis by targeting TLR6. Wang HF, etal., Eur Rev Med Pharmacol Sci. 2019 Apr;23(7):2971-2977. doi: 10.26355/eurrev_201904_17578.
15. MicroRNA-494 targeting both proapoptotic and antiapoptotic proteins protects against ischemia/reperfusion-induced cardiac injury. Wang X, etal., Circulation. 2010 Sep 28;122(13):1308-18. doi: 10.1161/CIRCULATIONAHA.110.964684. Epub 2010 Sep 13.
16. MicroRNA-494-3p protects rat cardiomyocytes against septic shock via PTEN. Wu P, etal., Exp Ther Med. 2019 Mar;17(3):1706-1716. doi: 10.3892/etm.2018.7116. Epub 2018 Dec 19.
17. MicroRNA-494-3p facilitates the progression of bladder cancer by mediating the KLF9/RGS2 axis. Xu XH, etal., Kaohsiung J Med Sci. 2022 Nov;38(11):1070-1079. doi: 10.1002/kjm2.12588. Epub 2022 Sep 13.
18. MicroRNA-494 promotes cyclosporine-induced nephrotoxicity and epithelial to mesenchymal transition by inhibiting PTEN. Yuan J, etal., Am J Transplant. 2015 Jun;15(6):1682-91. doi: 10.1111/ajt.13161. Epub 2015 Apr 6.
19. MicroRNA-494 inhibits breast cancer progression by directly targeting PAK1. Zhan MN, etal., Cell Death Dis. 2017 Jan 5;8(1):e2529. doi: 10.1038/cddis.2016.440.
20. Upregulation of miR-494 Inhibits Cell Growth and Invasion and Induces Cell Apoptosis by Targeting Cleft Lip and Palate Transmembrane 1-Like in Esophageal Squamous Cell Carcinoma. Zhang R, etal., Dig Dis Sci. 2015 May;60(5):1247-55. doi: 10.1007/s10620-014-3433-7. Epub 2014 Dec 6.
21. Silencing of microRNA-494 inhibits the neurotoxic Th1 shift via regulating HDAC2-STAT4 cascade in ischaemic stroke. Zhao H, etal., Br J Pharmacol. 2020 Jan;177(1):128-144. doi: 10.1111/bph.14852. Epub 2019 Nov 8.
22. Inhibited HDAC3 or Elevated MicroRNA-494-3p Plays a Protective Role in Myocardial Ischemia-Reperfusion Injury via Suppression of BRD4. Zheng W, etal., Mol Neurobiol. 2021 Sep;58(9):4268-4279. doi: 10.1007/s12035-021-02369-y. Epub 2021 May 12.
23. MicroRNA-494 improves functional recovery and inhibits apoptosis by modulating PTEN/AKT/mTOR pathway in rats after spinal cord injury. Zhu H, etal., Biomed Pharmacother. 2017 Aug;92:879-887. doi: 10.1016/j.biopha.2017.05.143. Epub 2017 Jun 7.
Additional References at PubMed
PMID:16274478   PMID:16381832   PMID:20403161   PMID:20439489   PMID:21247879   PMID:24349514   PMID:26786313   PMID:28368292   PMID:28842516   PMID:30816451   PMID:31008486   PMID:33174056  
PMID:34635862   PMID:36772911   PMID:37085803   PMID:37301960   PMID:37603538  


Genomics

Comparative Map Data
Mir494
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr86134,550,115 - 134,550,197 (+)NCBIGRCr8
mRatBN7.26128,728,710 - 128,728,792 (+)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl6128,728,709 - 128,728,793 (+)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx6128,907,952 - 128,908,034 (+)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.06129,203,784 - 129,203,866 (+)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.06128,565,401 - 128,565,483 (+)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.06133,864,370 - 133,864,452 (+)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl6133,864,369 - 133,864,453 (+)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.06143,026,541 - 143,026,623 (+)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera6126,313,091 - 126,313,173 (+)NCBICelera
Cytogenetic Map6q32NCBI
MIR494
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh3814101,029,634 - 101,029,714 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl14101,029,634 - 101,029,714 (+)EnsemblGRCh38hg38GRCh38
GRCh3714101,495,971 - 101,496,051 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 3614100,565,723 - 100,565,803 (+)NCBINCBI36Build 36hg18NCBI36
Celera1481,552,015 - 81,552,095 (+)NCBICelera
Cytogenetic Map14q32.31NCBI
HuRef1481,679,466 - 81,679,546 (+)NCBIHuRef
CHM1_114101,434,107 - 101,434,187 (+)NCBICHM1_1
T2T-CHM13v2.01495,265,090 - 95,265,170 (+)NCBIT2T-CHM13v2.0
Mir494
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm3912109,681,752 - 109,681,836 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl12109,681,752 - 109,681,836 (+)EnsemblGRCm39 Ensembl
GRCm3812109,715,318 - 109,715,402 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl12109,715,318 - 109,715,402 (+)EnsemblGRCm38mm10GRCm38
MGSCv3712110,953,528 - 110,953,612 (+)NCBIGRCm37MGSCv37mm9NCBIm37
Celera12110,912,544 - 110,912,628 (+)NCBICelera
Cytogenetic Map12F1NCBI
cM Map1260.56NCBI
MIR494
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1869,261,385 - 69,261,465 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl869,261,385 - 69,261,465 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha868,779,460 - 68,779,540 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0869,543,096 - 69,543,176 (+)NCBIROS_Cfam_1.0
UMICH_Zoey_3.1869,206,644 - 69,206,724 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0869,272,734 - 69,272,814 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0869,670,734 - 69,670,814 (+)NCBIUU_Cfam_GSD_1.0

miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
Vsnl1rno-miR-494-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)18258830

Predicted Targets
Summary Value
Count of predictions:12946
Count of gene targets:7419
Count of transcripts:7995
Interacting mature miRNAs:rno-miR-494-3p, rno-miR-494-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
731173Uae22Urinary albumin excretion QTL 2210.1urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
2290393Uae37Urinary albumin excretion QTL 370.0001urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)665531555140994061Rat
724536Uae7Urinary albumin excretion QTL 73.5urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)672202632130729475Rat
1331799Bp211Blood pressure QTL 2113.66407arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)672202632130919985Rat
1581550Pur8Proteinuria QTL 8urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)672227641130729205Rat
1581563Uae33Urinary albumin excretion QTL 33urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)672227641130729205Rat
738034Anxrr5Anxiety related response QTL 55.9exploratory behavior trait (VT:0010471)percentage of entries into a discrete space in an experimental apparatus (CMO:0000961)684130881129130881Rat
10054138Gmadr3Adrenal mass QTL 33.680.00045adrenal gland mass (VT:0010420)both adrenal glands wet weight (CMO:0000164)685140138130140138Rat
10054123Srcrt6Stress Responsive Cort QTL 62.50.0043blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)685140138130140138Rat
724513Uae14Urinary albumin excretion QTL 146.5urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)685311061133478515Rat
1300076Glom8Glomerulus QTL 870.000000009kidney glomerulus morphology trait (VT:0005325)count of superficial glomeruli directly contacting the kidney surface (CMO:0001001)686894788131894788Rat
2303624Vencon5Ventilatory control QTL 54.45respiration trait (VT:0001943)minute ventilation (CMO:0000132)688047916133047916Rat
61414Pia3Pristane induced arthritis QTL 34.5joint integrity trait (VT:0010548)post-insult time to onset of experimental arthritis (CMO:0001450)694968928137848904Rat
12801411Schws8Schwannoma susceptibility QTL 8nervous system integrity trait (VT:0010566)percentage of study population developing trigeminal nerve neurilemmomas during a period of time (CMO:0002017)694968928139968928Rat
8552796Vie3Viral induced encephalitis QTL 32.6brain integrity trait (VT:0010579)encephalitis incidence/prevalence measurement (CMO:0002361)696833997140994061Rat
1358355Srcrt4Stress Responsive Cort QTL 46.39blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)6100364669140994061Rat
2313399Anxrr28Anxiety related response QTL 28aggression-related behavior trait (VT:0015014)tameness/aggressiveness composite score (CMO:0002136)6100671796132340886Rat
71111Iddm8Insulin dependent diabetes mellitus QTL 81.90.002blood glucose amount (VT:0000188)plasma glucose level (CMO:0000042)6105156861140994061Rat
4145118Mcs26Mammary carcinoma susceptibility QTL 260.0001mammary gland integrity trait (VT:0010552)post-insult time to mammary tumor formation (CMO:0000345)6106752656132339866Rat
737976Pia24Pristane induced arthritis QTL 24joint integrity trait (VT:0010548)joint inflammation composite score (CMO:0000919)6112636280140994061Rat
1298087Iddm18Insulin dependent diabetes mellitus QTL 180.0001urine glucose amount (VT:0001758)percentage of study population developing diabetes mellitus during a period of time (CMO:0001114)6116506292130245370Rat
1641917Colcr5Colorectal carcinoma resistance QTL 53.180.0009intestine integrity trait (VT:0010554)benign colorectal tumor number (CMO:0001795)6122549046137801795Rat
2293085Iddm29Insulin dependent diabetes mellitus QTL 297.66blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)6122549046140286318Rat
61329Eae9Experimental allergic encephalomyelitis QTL 93.7body mass (VT:0001259)change in body weight (CMO:0002045)6122549046140994061Rat
2312560Pur20Proteinuria QTL 202.10.005urine total protein amount (VT:0000032)urine total protein excretion rate (CMO:0000756)6125628133137801795Rat


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

circulatory system endocrine system exocrine system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 5 1 1 2 1
Low 6 3 3 2 2 8 8 1 2
Below cutoff 1 2 2 2 2 1

Sequence

Nucleotide Sequences
RefSeq Transcripts NR_032125 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide JAXUCZ010000006 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

RefSeq Acc Id: ENSRNOT00000054367
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl6128,728,709 - 128,728,793 (+)Ensembl
Rnor_6.0 Ensembl6133,864,369 - 133,864,453 (+)Ensembl
RefSeq Acc Id: NR_032125
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr86134,550,115 - 134,550,197 (+)NCBI
mRatBN7.26128,728,710 - 128,728,792 (+)NCBI
Rnor_6.06133,864,370 - 133,864,452 (+)NCBI
Rnor_5.06143,026,541 - 143,026,623 (+)NCBI
Celera6126,313,091 - 126,313,173 (+)NCBI
Sequence:
Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2325523 AgrOrtholog
BioCyc Gene G2FUF-36011 BioCyc
Ensembl Genes ENSRNOG00000036244 Ensembl, ENTREZGENE
Ensembl Transcript ENSRNOT00000054367 ENTREZGENE
miRBase MI0003542 ENTREZGENE
NCBI Gene 100314082 ENTREZGENE
PhenoGen Mir494 PhenoGen
RatGTEx ENSRNOG00000036244 RatGTEx
RNAcentral URS0000031935 RNACentral
  URS00004C94DA RNACentral
  URS000075E0E9 RNACentral


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2013-08-14 Mir494  microRNA 494  Mir494  microRNA mir-494  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2010-06-02 Mir494  microRNA mir-494      Symbol and Name status set to provisional 70820 PROVISIONAL