RGD Reference Report - Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4. - Rat Genome Database
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Neuroprotective effect of ghrelin is associated with decreased expression of prostate apoptosis response-4.

Authors: Hwang, S  Moon, M  Kim, S  Hwang, L  Ahn, KJ  Park, S 
Citation: Hwang S, etal., Endocr J. 2009;56(4):609-17. Epub 2009 Apr 7.
RGD ID: 9850083
Pubmed: (View Article at PubMed) PMID:19352052

Ghrelin is known to promote neuronal defense and survival against ischemic injury by inhibiting apoptotic processes. In the present study, we investigated the role of prostate apoptosis response-4 (Par-4), a proapoptotic gene the expression of which is increased after ischemic injury, in ghrelin-mediated neuroprotection during middle cerebral artery occlusion (MCAO). Both ghrelin and des-acyl ghrelin protected cortical neurons from ischemic injury. Ghrelin receptor specific antagonist abolished the protective effects of ghrelin, whereas those of des-acyl ghrelin were preserved, suggesting the involvement of a receptor that is distinct from GHS-R1a. The expression of Par-4 was increased by MCAO, which was attenuated by ghrelin and des-acyl ghrelin treatments. Both ghrelin and des-acyl ghrelin increased the Bcl-2/Bax ratio, prevented cytochrome c release, and inhibited caspase-3 activation. Our data indicate that des-acyl ghrelin, as well as ghrelin, protect cortical neurons against ischemic injury through the inhibition of Par-4 expression and apoptotic molecules in mitochondrial pathway.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Ghrl  (ghrelin and obestatin prepropeptide)
Ghsr  (growth hormone secretagogue receptor)
Pawr  (pro-apoptotic WT1 regulator)

Genes (Mus musculus)
Ghrl  (ghrelin)
Ghsr  (growth hormone secretagogue receptor)
Pawr  (PRKC, apoptosis, WT1, regulator)

Genes (Homo sapiens)
GHRL  (ghrelin and obestatin prepropeptide)
GHSR  (growth hormone secretagogue receptor)
PAWR  (pro-apoptotic WT1 regulator)


Additional Information