Bcan (brevican) - Rat Genome Database

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Gene: Bcan (brevican) Rattus norvegicus
Analyze
Symbol: Bcan
Name: brevican
RGD ID: 2194
Description: Predicted to enable calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in cell-matrix adhesion; nervous system development; and regulation of neuronal synaptic plasticity. Located in several cellular components, including cell surface; main axon; and perineuronal net. Is active in GABA-ergic synapse; glutamatergic synapse; and perisynaptic extracellular matrix. Used to study high grade glioma. Biomarker of high grade glioma and middle cerebral artery infarction. Orthologous to human BCAN (brevican); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Previously known as: ALPBRE; BEHAB; brain-enriched hyaluronan-binding protein; Brevican (brain specific proteoglycan in the aggrecan family); brevican core protein; brevican core protein-like; LOC100910284
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Latest Assembly: mRatBN7.2 - mRatBN7.2 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,454,479 - 173,467,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,454,482 - 173,467,460 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,599,269 - 180,612,251 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02178,621,629 - 178,634,612 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02173,221,686 - 173,234,840 (-)NCBIRnor_WKY
Rnor_6.02187,359,674 - 187,373,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,359,677 - 187,372,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,762,691 - 206,776,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,067,864 - 180,080,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,022,993 - 180,030,847 (-)NCBI
Celera2167,401,907 - 167,414,841 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. Abnormal post-translational and extracellular processing of brevican in plaque-bearing mice over-expressing APPsw. Ajmo JM, etal., J Neurochem. 2010 May;113(3):784-95. doi: 10.1111/j.1471-4159.2010.06647.x. Epub 2010 Feb 17.
2. The effect of hypoxic-ischemic brain injury in perinatal rats on the abundance and proteolysis of brevican and NG2. Aya-ay J, etal., Exp Neurol. 2005 May;193(1):149-62. doi: 10.1016/j.expneurol.2004.11.021.
3. Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. Carmichael ST, etal., Exp Neurol. 2005 Jun;193(2):291-311.
4. Decorin suppresses neurocan, brevican, phosphacan and NG2 expression and promotes axon growth across adult rat spinal cord injuries. Davies JE, etal., Eur J Neurosci. 2004 Mar;19(5):1226-42.
5. Composition of perineuronal net extracellular matrix in rat brain: a different disaccharide composition for the net-associated proteoglycans. Deepa SS, etal., J Biol Chem. 2006 Jun 30;281(26):17789-800. Epub 2006 Apr 27.
6. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
7. Immunohistochemical evidence for the brevican-tenascin-R interaction: colocalization in perineuronal nets suggests a physiological role for the interaction in the adult rat brain. Hagihara K, etal., J Comp Neurol. 1999 Jul 26;410(2):256-64.
8. Altered production and proteolytic processing of brevican by transforming growth factor beta in cultured astrocytes. Hamel MG, etal., J Neurochem. 2005 Jun;93(6):1533-41.
9. Neurofascin assembles a specialized extracellular matrix at the axon initial segment. Hedstrom KL, etal., J Cell Biol. 2007 Aug 27;178(5):875-86. doi: 10.1083/jcb.200705119. Epub 2007 Aug 20.
10. BEHAB, a new member of the proteoglycan tandem repeat family of hyaluronan-binding proteins that is restricted to the brain. Jaworski DM, etal., J Cell Biol 1994 Apr;125(2):495-509.
11. The CNS-specific hyaluronan-binding protein BEHAB is expressed in ventricular zones coincident with gliogenesis. Jaworski DM, etal., J Neurosci. 1995 Feb;15(2):1352-62.
12. Brevican-containing perineuronal nets of extracellular matrix in dissociated hippocampal primary cultures. John N, etal., Mol Cell Neurosci. 2006 Apr;31(4):774-84. doi: 10.1016/j.mcn.2006.01.011. Epub 2006 Feb 28.
13. The role of brevican in glioma: promoting tumor cell motility in vitro and in vivo. Lu R, etal., BMC Cancer. 2012 Dec 19;12:607. doi: 10.1186/1471-2407-12-607.
14. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
15. Carbohydrate-protein interactions between HNK-1-reactive sulfoglucuronyl glycolipids and the proteoglycan lectin domain mediate neuronal cell adhesion and neurite outgrowth. Miura R, etal., J Neurochem. 2001 Jan;76(2):413-24.
16. Alterations in protein regulators of neurodevelopment in the cerebrospinal fluid of infants with post-hemorrhagic hydrocephalus of prematurity. Morales DM, etal., Mol Cell Proteomics. 2011 Dec 20.
17. Electronic Transfer of LocusLink and RefSeq Data NCBI rat LocusLink and RefSeq merged data July 26, 2002
18. Brain enriched hyaluronan binding (BEHAB)/brevican increases aggressiveness of CNS-1 gliomas in Lewis rats. Nutt CL, etal., Cancer Res. 2001 Oct 1;61(19):7056-9.
19. GOA pipeline RGD automated data pipeline
20. ClinVar Automated Import and Annotation Pipeline RGD automated import pipeline for ClinVar variants, variant-to-disease annotations and gene-to-disease annotations
21. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
22. Brevican, a chondroitin sulfate proteoglycan of rat brain, occurs as secreted and cell surface glycosylphosphatidylinositol-anchored isoforms. Seidenbecher CI, etal., J Biol Chem 1995 Nov 10;270(45):27206-12.
23. [Clinical consideration with special reference to autopsy cases of malignant tumor in the oral cavity, treated with Bleomycin (author's transl)] Tanaka S, etal., Hiroshima Daigaku Shigaku Zasshi 1975;8(2):168-75.
24. Changes in distribution, cell associations, and protein expression levels of NG2, neurocan, phosphacan, brevican, versican V2, and tenascin-C during acute to chronic maturation of spinal cord scar tissue. Tang X, etal., J Neurosci Res 2003 Feb 1;71(3):427-44.
25. Tentative Sequence Identification Numbers Tentative Sequence Data IDs. TIGR Gene Index, Rat Data
26. Novel tumor-specific isoforms of BEHAB/brevican identified in human malignant gliomas. Viapiano MS, etal., Cancer Res. 2005 Aug 1;65(15):6726-33. doi: 10.1158/0008-5472.CAN-05-0585.
27. A novel membrane-associated glycovariant of BEHAB/brevican is up-regulated during rat brain development and in a rat model of invasive glioma. Viapiano MS, etal., J Biol Chem. 2003 Aug 29;278(35):33239-47. doi: 10.1074/jbc.M303480200. Epub 2003 Jun 10.
28. Müller glial microRNAs are required for the maintenance of glial homeostasis and retinal architecture. Wohl SG, etal., Nat Commun. 2017 Nov 17;8(1):1603. doi: 10.1038/s41467-017-01624-y.
29. cDNA cloning and the identification of an aggrecanase-like cleavage site in rat brevican. Yamada H, etal., Biochem Biophys Res Commun 1995 Nov 22;216(3):957-63.
Additional References at PubMed
PMID:8889548   PMID:9294172   PMID:12370289   PMID:12379262   PMID:12477932   PMID:17972319   PMID:19141078   PMID:25052349   PMID:28712654   PMID:29476059  


Genomics

Comparative Map Data
Bcan
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
mRatBN7.22173,454,479 - 173,467,717 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl2173,454,482 - 173,467,460 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx2180,599,269 - 180,612,251 (-)NCBIRnor_SHR
UTH_Rnor_SHRSP_BbbUtx_1.02178,621,629 - 178,634,612 (-)NCBIRnor_SHRSP
UTH_Rnor_WKY_Bbb_1.02173,221,686 - 173,234,840 (-)NCBIRnor_WKY
Rnor_6.02187,359,674 - 187,373,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,359,677 - 187,372,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,762,691 - 206,776,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,067,864 - 180,080,942 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.12180,022,993 - 180,030,847 (-)NCBI
Celera2167,401,907 - 167,414,841 (-)NCBICelera
Cytogenetic Map2q34NCBI
BCAN
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,642,117 - 156,659,528 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p13 Ensembl1156,641,390 - 156,659,532 (+)EnsemblGRCh38hg38GRCh38
GRCh371156,611,909 - 156,629,320 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,878,364 - 154,895,944 (+)NCBINCBI36Build 36hg18NCBI36
Build 341153,424,812 - 153,442,391NCBI
Celera1129,682,549 - 129,700,133 (+)NCBICelera
Cytogenetic Map1q23.1NCBI
HuRef1127,969,333 - 127,986,922 (+)NCBIHuRef
CHM1_11158,007,947 - 158,025,532 (+)NCBICHM1_1
T2T-CHM13v2.01155,778,497 - 155,795,916 (+)NCBIT2T-CHM13v2.0
Bcan
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39387,894,838 - 87,911,134 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl387,894,838 - 87,907,537 (-)EnsemblGRCm39 Ensembl
GRCm38387,987,531 - 88,002,175 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl387,987,531 - 88,000,230 (-)EnsemblGRCm38mm10GRCm38
MGSCv37387,791,453 - 87,804,278 (-)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36388,073,458 - 88,086,157 (-)NCBIMGSCv36mm8
Celera388,024,909 - 88,037,731 (-)NCBICelera
Cytogenetic Map3F1NCBI
cM Map338.78NCBI
Bcan
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555452,723,780 - 2,739,450 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555452,723,780 - 2,739,334 (+)NCBIChiLan1.0ChiLan1.0
BCAN
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
PanPan1.11135,808,783 - 135,826,344 (+)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1135,808,783 - 135,826,344 (+)Ensemblpanpan1.1panPan2
Mhudiblu_PPA_v01131,985,310 - 132,003,068 (+)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
BCAN
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1741,313,578 - 41,330,178 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl741,313,579 - 41,330,178 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha740,800,863 - 40,817,472 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0741,176,717 - 41,193,313 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl741,176,718 - 41,248,421 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1740,958,653 - 40,975,224 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0741,011,623 - 41,028,215 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0741,295,291 - 41,311,883 (-)NCBIUU_Cfam_GSD_1.0
Bcan
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_02440505826,785,957 - 26,798,152 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365805,816,359 - 5,828,126 (+)EnsemblSpeTri2.0
SpeTri2.0NW_0049365805,816,196 - 5,828,531 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
BCAN
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl493,432,330 - 93,450,831 (-)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1493,432,331 - 93,450,895 (-)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.24102,095,832 - 102,114,192 (-)NCBISscrofa10.2Sscrofa10.2susScr3
BCAN
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1207,203,546 - 7,221,108 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl207,203,378 - 7,220,973 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660386,499,085 - 6,516,895 (-)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Bcan
(Heterocephalus glaber - naked mole-rat)
Naked Mole-rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046248851,820,105 - 1,832,510 (+)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046248851,816,591 - 1,829,971 (+)NCBIHetGla_female_1.0HetGla 1.0hetGla2

Variants

.
Variants in Bcan
32 total Variants
miRNA Target Status

Predicted Target Of
Summary Value
Count of predictions:50
Count of miRNA genes:43
Interacting mature miRNAs:49
Transcripts:ENSRNOT00000025496
Prediction methods:Miranda, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (mRatBN7.2)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1358913Cm41Cardiac mass QTL 412.73heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
1358917Cm42Cardiac mass QTL 422.82heart mass (VT:0007028)heart weight to body weight ratio (CMO:0000074)225413423203928301Rat
2293843Kiddil6Kidney dilation QTL 63.1kidney pelvis morphology trait (VT:0004194)hydronephrosis severity score (CMO:0001208)242804607182042367Rat
1298074Bp164Blood pressure QTL 1640.003arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
1298085Bp165Blood pressure QTL 1650.0006arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)242804607202447032Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)243154682202446871Rat
61467Bp14Blood pressure QTL 142.2arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)243154682202446871Rat
1354601Slep1Serum leptin concentration QTL 15.39blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)243171017184114403Rat
631266Bp132Blood pressure QTL 1320.0005arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)246123260202447032Rat
1331760Bp206Blood pressure QTL 2063.62454arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)256043031202447032Rat
1298080Bp163Blood pressure QTL 1630.02arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118275202447032Rat
1354648Bp239Blood pressure QTL 2390.001arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)266118463226797303Rat
1354605Rf48Renal function QTL 482.9blood creatinine amount (VT:0005328)plasma creatinine level (CMO:0000537)274786664206665859Rat
61374Edpm2Estrogen-dependent pituitary mass QTL 24.420.86pituitary gland mass (VT:0010496)pituitary gland wet weight (CMO:0000853)276539322202447032Rat
1581569Uae32Urinary albumin excretion QTL 320.0001urine protein amount (VT:0005160)urine albumin excretion rate (CMO:0000757)278665619219826953Rat
724534Uae6Urinary albumin excretion QTL 610urine albumin amount (VT:0002871)urine albumin level (CMO:0000130)278665619249053267Rat
8662832Vetf7Vascular elastic tissue fragility QTL 73.5aorta elastin amount (VT:0003905)aorta wall extracellular elastin dry weight to aorta wall dry weight ratio (CMO:0002002)281689826221035911Rat
1354622Kidm16Kidney mass QTL 163kidney mass (VT:0002707)left kidney wet weight (CMO:0000083)281754530222436696Rat
1354649Kidm17Kidney mass QTL 172.9kidney mass (VT:0002707)calculated kidney weight (CMO:0000160)281754530227146641Rat
631507Bp105Blood pressure QTL 1050.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2112456140212696837Rat
634308Sach6Saccharin preference QTL 64.9taste sensitivity trait (VT:0001986)saccharin intake volume to total fluid intake volume ratio (CMO:0001601)2112456140212696837Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2114837527185876470Rat
1359030Bp277Blood pressure QTL 277arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2114837527185876470Rat
1578648Bss11Bone structure and strength QTL 114.7femur morphology trait (VT:0000559)femoral neck cortical cross-sectional area (CMO:0001702)2114837527211674221Rat
1554319Bmd2Bone mineral density QTL 213.40.0001lumbar vertebra area (VT:0010570)lumbar vertebra cross-sectional area (CMO:0001689)2114837675212549332Rat
6907363Bp357Blood pressure QTL 3574.10.002arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2129540907174540907Rat
1300165Rf9Renal function QTL 93.28kidney glomerulus integrity trait (VT:0010546)index of glomerular damage (CMO:0001135)2133914684202447032Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)diastolic blood pressure (CMO:0000005)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)pulse pressure (CMO:0000292)2135552573202446871Rat
70175BpQTLCluster3Blood pressure QTL cluster 34.128arterial blood pressure trait (VT:2000000)absolute change in systolic blood pressure (CMO:0000607)2135552573202446871Rat
1298076Bp166Blood pressure QTL 1660.0009arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2136445150202447032Rat
1581502Esta3Estrogen-induced thymic atrophy QTL 3thymus mass (VT:0004954)thymus wet weight (CMO:0000855)2136916935189599348Rat
1359022Ppulsi1Prepulse inhibition QTL 13.63prepulse inhibition trait (VT:0003088)acoustic startle response measurement (CMO:0001519)2136916935213594495Rat
1331794Bp202Blood pressure QTL 2023.66819arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2141194931223265385Rat
1331805Cm29Cardiac mass QTL 293.50746heart mass (VT:0007028)heart wet weight (CMO:0000069)2141194931223265385Rat
71113Cari2Carrageenan-induced inflammation QTL 22.70.009hypodermis integrity trait (VT:0010550)inflammatory exudate volume (CMO:0001429)2141596551202447032Rat
724568Uae13Urinary albumin excretion QTL 134.4urine albumin amount (VT:0002871)urine albumin excretion rate (CMO:0000757)2143157029210020885Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2143657411190602963Rat
10043136Iddm54Insulin dependent diabetes mellitus QTL 543.40.0001blood glucose amount (VT:0000188)age at onset/diagnosis of type 1 diabetes mellitus (CMO:0001140)2143657411190602963Rat
6903312Bw112Body weight QTL 1123.20.0013body mass (VT:0001259)body weight (CMO:0000012)2143657569184114274Rat
61401Niddm2Non-insulin dependent diabetes mellitus QTL 24.54blood glucose amount (VT:0000188)blood glucose level (CMO:0000046)2144599348189599348Rat
1598833Bp295Blood pressure QTL 2953.5arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2147798556192798556Rat
1641925Alcrsp2Alcohol response QTL 2response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561221167075Rat
1641891Alcrsp17Alcohol response QTL 17response to alcohol trait (VT:0010489)duration of loss of righting reflex (CMO:0002289)2149559561249053267Rat
1598805Memor8Memory QTL 83exploratory behavior trait (VT:0010471)average horizontal distance between subject and target during voluntary locomotion in an experimental apparatus (CMO:0002674)2150341585189039377Rat
631501Bp101Blood pressure QTL 1012.4arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150341684202446871Rat
2301966Bp322Blood pressure QTL 3223.58arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2150540301202447032Rat
1354609Niddm62Non-insulin dependent diabetes mellitus QTL 624.720.000006insulin secretion trait (VT:0003564)plasma insulin level (CMO:0000342)2150540301202447032Rat
12879845Cm89Cardiac mass QTL 890.008heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072175950118Rat
12879846Cm90Cardiac mass QTL 900.011heart right ventricle mass (VT:0007033)heart right ventricle weight to body weight ratio (CMO:0000914)2152413072175950118Rat
12879847Am4Aortic mass QTL 40.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072175950118Rat
11565180Kidm56Kidney mass QTL 560.003kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072175950118Rat
11565181Bw176Body weight QTL 1760.002body mass (VT:0001259)body weight (CMO:0000012)2152413072175950118Rat
2301415Cm67Cardiac mass QTL 670.003heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072175950118Rat
12879836Kidm61Kidney mass QTL 610.001kidney mass (VT:0002707)both kidneys wet weight to body weight ratio (CMO:0000340)2152413072185122374Rat
12879837Am2Aortic mass QTL 20.001aorta mass (VT:0002845)aorta weight to aorta length to body weight ratio (CMO:0002722)2152413072185122374Rat
12879838Cm86Cardiac mass QTL 860.002heart left ventricle mass (VT:0007031)heart left ventricle weight to body weight ratio (CMO:0000530)2152413072185122374Rat
12879839Cm85Cardiac mass QTL 850.001heart mass (VT:0007028)heart wet weight to body weight ratio (CMO:0002408)2152413072185122374Rat
12879840Bw179Body weight QTL 1790.005body mass (VT:0001259)body weight (CMO:0000012)2152413072185122374Rat
1359032Hrtrt18Heart rate QTL 18heart pumping trait (VT:2000009)heart rate (CMO:0000002)2157142078192625452Rat
1358900Bw48Body weight QTL 484.88body mass (VT:0001259)body weight (CMO:0000012)2157142078211086598Rat
8662843Vetf9Vascular elastic tissue fragility QTL 92.05thoracic aorta molecular composition trait (VT:0010568)aorta wall extracellular elastin dry weight to aorta wall extracellular collagen weight ratio (CMO:0002003)2157142078226277316Rat
1302793Bw16Body weight QTL 1650.0001body mass (VT:0001259)body weight (CMO:0000012)2157142209202446871Rat
7488925Bp364Blood pressure QTL 3640.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2160564068205564068Rat
1358356Srcrt1Stress Responsive Cort QTL13.66blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)2161699179222436696Rat
7488927Bp365Blood pressure QTL 3650.008arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2162765032207765032Rat
2306901Bp337Blood pressure QTL 3370.01arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2164073756227146641Rat
1598838Bp290Blood pressure QTL 2901.9arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2166539266211539266Rat
1549833Bp257Blood pressure QTL 2570.003arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168354880185122374Rat
1331734Bp204Blood pressure QTL 2043.61192arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2168358098223265385Rat
2307174Activ3Activity QTL 34.830.000058locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)2168594495213594495Rat
61469Bp16Blood pressure QTL 165.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
70162Bp63Blood pressure QTL 635.64arterial blood pressure trait (VT:2000000)blood pressure measurement (CMO:0000003)2169745596214745596Rat
61473Bp19Blood pressure QTL 196.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921175950118Rat
631522Bp74Blood pressure QTL 740.05arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)2172710921184114403Rat
7488904Bp363Blood pressure QTL 3630.001arterial blood pressure trait (VT:2000000)mean arterial blood pressure (CMO:0000009)2172982062175950118Rat

Markers in Region
RH138503  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,454,576 - 173,454,703 (+)MAPPERmRatBN7.2
Rnor_6.02184,915,756 - 184,915,882NCBIRnor6.0
Rnor_6.02187,359,772 - 187,359,898NCBIRnor6.0
Rnor_5.02206,762,789 - 206,762,915UniSTSRnor5.0
Rnor_5.02204,306,829 - 204,306,955UniSTSRnor5.0
RGSC_v3.42180,067,962 - 180,068,088UniSTSRGSC3.4
Celera2167,402,005 - 167,402,131UniSTS
RH 3.4 Map21130.0UniSTS
Cytogenetic Map2q34UniSTS
UniSTS:224394  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.22173,454,497 - 173,454,660 (+)MAPPERmRatBN7.2
Rnor_6.02184,915,677 - 184,915,839NCBIRnor6.0
Rnor_6.02187,359,693 - 187,359,855NCBIRnor6.0
Rnor_5.02204,306,750 - 204,306,912UniSTSRnor5.0
Rnor_5.02206,762,710 - 206,762,872UniSTSRnor5.0
RGSC_v3.42180,067,883 - 180,068,045UniSTSRGSC3.4
Celera2167,401,926 - 167,402,088UniSTS
Cytogenetic Map2q34UniSTS


Expression


RNA-SEQ Expression
High: > 1000 TPM value   Medium: Between 11 and 1000 TPM
Low: Between 0.5 and 10 TPM   Below Cutoff: < 0.5 TPM

alimentary part of gastrointestinal system circulatory system endocrine system exocrine system hemolymphoid system hepatobiliary system integumental system musculoskeletal system nervous system renal system reproductive system respiratory system appendage
High
Medium 1 54
Low 5 9 2 10 11 7
Below cutoff 2 23 23 17 16 17 8 8 4 4 18 4 8

Sequence

Nucleotide Sequences
RefSeq Transcripts NM_001033665 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  NM_012916 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232596 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_006232597 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590643 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_017590645 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101784 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101785 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101786 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101787 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101788 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101789 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XM_039101790 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_001836420 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500246 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  XR_005500247 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
GenBank Nucleotide AI535159 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  BC094307 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB577797 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB784255 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CB810773 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  CH473976 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  JACYVU010000069 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  U37142 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X79881 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  X86406 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles
  Z28366 (Get FASTA)   NCBI Sequence Viewer   Search GEO for Microarray Profiles

Reference Sequences
RefSeq Acc Id: ENSRNOT00000025496   ⟹   ENSRNOP00000025496
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl2173,454,482 - 173,467,460 (-)Ensembl
Rnor_6.0 Ensembl2187,359,677 - 187,372,652 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000080610
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2184,915,247 - 184,917,462 (-)Ensembl
RefSeq Acc Id: ENSRNOT00000083116   ⟹   ENSRNOP00000070660
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.0 Ensembl2187,366,297 - 187,372,657 (-)Ensembl
RefSeq Acc Id: NM_001033665   ⟹   NP_001028837
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,467,460 (-)NCBI
Rnor_6.02187,359,674 - 187,372,652 (-)NCBI
Rnor_5.02206,762,691 - 206,776,016 (-)NCBI
RGSC_v3.42180,067,864 - 180,080,942 (-)RGD
Celera2167,401,907 - 167,414,841 (-)RGD
Sequence:
RefSeq Acc Id: NM_012916   ⟹   NP_037048
RefSeq Status: VALIDATED
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,459,486 - 173,467,460 (-)NCBI
Rnor_6.02187,364,678 - 187,372,652 (-)NCBI
Rnor_5.02206,762,691 - 206,776,016 (-)NCBI
RGSC_v3.42180,067,864 - 180,080,942 (-)RGD
Celera2167,406,914 - 167,414,841 (-)NCBI
Sequence:
RefSeq Acc Id: XM_039101784   ⟹   XP_038957712
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,465,898 (-)NCBI
RefSeq Acc Id: XM_039101785   ⟹   XP_038957713
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,465,898 (-)NCBI
RefSeq Acc Id: XM_039101786   ⟹   XP_038957714
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,465,898 (-)NCBI
RefSeq Acc Id: XM_039101787   ⟹   XP_038957715
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,467,717 (-)NCBI
RefSeq Acc Id: XM_039101788   ⟹   XP_038957716
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,467,717 (-)NCBI
RefSeq Acc Id: XM_039101789   ⟹   XP_038957717
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,465,813 (-)NCBI
RefSeq Acc Id: XM_039101790   ⟹   XP_038957718
RefSeq Status:
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,466,774 (-)NCBI
RefSeq Acc Id: XR_005500246
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,479 - 173,465,898 (-)NCBI
RefSeq Acc Id: XR_005500247
RefSeq Status:
Type: NON-CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.22173,454,795 - 173,465,898 (-)NCBI
Reference Sequences
RefSeq Acc Id: NP_001028837   ⟸   NM_001033665
- Peptide Label: isoform 1 precursor
- UniProtKB: P55068 (UniProtKB/Swiss-Prot),   G3V8G4 (UniProtKB/TrEMBL)
- Sequence:
RefSeq Acc Id: NP_037048   ⟸   NM_012916
- Peptide Label: isoform 2 precursor
- UniProtKB: P55068 (UniProtKB/Swiss-Prot)
- Sequence:
RefSeq Acc Id: ENSRNOP00000070660   ⟸   ENSRNOT00000083116
RefSeq Acc Id: ENSRNOP00000025496   ⟸   ENSRNOT00000025496
RefSeq Acc Id: XP_038957715   ⟸   XM_039101787
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957716   ⟸   XM_039101788
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957718   ⟸   XM_039101790
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957713   ⟸   XM_039101785
- Peptide Label: isoform X2
RefSeq Acc Id: XP_038957714   ⟸   XM_039101786
- Peptide Label: isoform X3
- UniProtKB: G3V8G4 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038957712   ⟸   XM_039101784
- Peptide Label: isoform X1
RefSeq Acc Id: XP_038957717   ⟸   XM_039101789
- Peptide Label: isoform X1
Protein Domains
C-type lectin   EGF-like   Ig-like   Ig-like V-type   Link   Sushi

Protein Structures
Name Modeler Protein Id AA Range Protein Structure
AF-P55068-F1-model_v2 AlphaFold P55068 1-883 view protein structure

Transcriptome

eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen


Additional Information

Database Acc Id Source(s)
AGR Gene RGD:2194 AgrOrtholog
BioCyc Gene G2FUF-52523 BioCyc
Ensembl Genes ENSRNOG00000018798 Ensembl, ENTREZGENE, UniProtKB/TrEMBL
  ENSRNOG00000058727 Ensembl
Ensembl Protein ENSRNOP00000025496 ENTREZGENE
  ENSRNOP00000025496.4 UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000025496 ENTREZGENE
  ENSRNOT00000025496.7 UniProtKB/TrEMBL
Gene3D-CATH 2.60.40.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  3.10.100.10 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
InterPro C-type_lectin-like UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin-like/link_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C-type_lectin_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CTDL_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF-like_Ca-bd_dom UniProtKB/TrEMBL
  EGF-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_dom_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig-like_fold UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig/MHC_CS UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_sub UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Ig_V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Link_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi/SCR/CCP_sf UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi_SCR_CCP_dom UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
KEGG Report rno:25393 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
NCBI Gene 25393 ENTREZGENE
Pfam EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Lectin_C UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Sushi UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  V-set UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  Xlink UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PhenoGen Bcan PhenoGen
PRINTS LINKMODULE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
PROSITE C_TYPE_LECTIN_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  C_TYPE_LECTIN_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_3 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_LIKE UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  IG_MHC UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_1 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK_2 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SUSHI UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
SMART CCP UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  CLECT UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  EGF_CA UniProtKB/TrEMBL
  IGv UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  LINK UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SM00409 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
Superfamily-SCOP SSF48726 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF56436 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
  SSF57535 UniProtKB/Swiss-Prot, UniProtKB/TrEMBL
TIGR TC218890
UniProt G3V8G4 ENTREZGENE, UniProtKB/TrEMBL
  P55068 ENTREZGENE, UniProtKB/Swiss-Prot
UniProt Secondary Q62860 UniProtKB/Swiss-Prot
  Q63040 UniProtKB/Swiss-Prot
  Q63513 UniProtKB/Swiss-Prot


Nomenclature History
Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2021-03-09 Bcan  brevican  LOC100910284  brevican core protein-like  Data Merged 737654 PROVISIONAL
2012-07-05 LOC100910284  brevican core protein-like      Symbol and Name status set to provisional 70820 PROVISIONAL
2002-06-10 Bcan  Brevican      Symbol and Name status set to approved 70586 APPROVED