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Gene: Bcan (brevican) Rattus norvegicus
Symbol: Bcan
Name: brevican
RGD ID: 2194
Description: Predicted to have calcium ion binding activity; carbohydrate binding activity; and hyaluronic acid binding activity. Involved in cell-matrix adhesion; nervous system development; and regulation of neuronal synaptic plasticity. Localizes to several cellular components, including GABA-ergic synapse; main axon; and perineuronal net. Used to study malignant glioma. Biomarker of malignant glioma and middle cerebral artery infarction. Orthologous to human BCAN (brevican); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 2,3,7,8-Tetrachlorodibenzofuran; 6-propyl-2-thiouracil.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: ALPBRE; BEHAB; brain-enriched hyaluronan-binding protein; Brevican (brain specific proteoglycan in the aggrecan family); brevican core protein
Homo sapiens (human) : BCAN (brevican)  HGNC  Alliance
Mus musculus (house mouse) : Bcan (brevican)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Bcan (brevican)
Pan paniscus (bonobo/pygmy chimpanzee) : BCAN (brevican)
Canis lupus familiaris (dog) : BCAN (brevican)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Bcan (brevican)
Sus scrofa (pig) : BCAN (brevican)
Chlorocebus sabaeus (African green monkey) : BCAN (brevican)
Heterocephalus glaber (naked mole-rat) : Bcan (brevican)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Rat AssemblyChrPosition (strand)SourceGenome Browsers
Rnor_6.02187,359,674 - 187,373,133 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl2187,359,677 - 187,372,657 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.02206,762,691 - 206,776,016 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.42180,067,864 - 180,080,942 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.12180,022,993 - 180,030,847 (-)NCBI
Celera2167,401,907 - 167,414,841 (-)NCBICelera
Cytogenetic Map2q34NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences

Strain Variation

Strain Sequence Variants (Rnor 6.0)
Damaging Variants

Additional Information

External Database Links
Nomenclature History
More on Bcan
Alliance Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 2194
Created: 2000-05-25
Species: Rattus norvegicus
Last Modified: 2020-08-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.