RGD Reference Report - Reelin-deficient mice show impaired neurogenesis and increased stroke size. - Rat Genome Database
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Reelin-deficient mice show impaired neurogenesis and increased stroke size.

Authors: Won, Seok Joon  Kim, Sun Hee  Xie, Lin  Wang, Yaoming  Mao, Xiao Ou  Jin, Kunlin  Greenberg, David A 
Citation: Won SJ, etal., Exp Neurol. 2006 Mar;198(1):250-9. Epub 2006 Jan 24.
RGD ID: 13207538
Pubmed: (View Article at PubMed) PMID:16438965
DOI: Full-text: DOI:10.1016/j.expneurol.2005.12.008

Reelin (Reln) is a protein involved in migration of newborn neurons during development. Reln mutations produce the reeler phenotype in mice, which is characterized by a defect in brain lamination, and autosomal recessive lissencephaly in humans. Reln expression persists in adult brain, but little is known about its function. We used reeler mice to investigate the effects of Reln deficiency on neurogenesis and the response to injury in the adult brain. Newborn neurons were decreased in number in the dentate gyrus and rostral migratory stream of reeler, compared to wild-type, mice. This was due, at least in part, to impaired cell migration. In addition, reeler mice showed increased susceptibility to ischemic brain injury. Cerebral infarcts from middle cerebral artery occlusion were larger in reeler than in wild-type mice, and associated neurobehavioral abnormalities were more severe. The brains of reeler mice also showed larger excitotoxic lesions after the intracerebral injection of N-methyl-D-aspartate. Finally, despite the fact that reeler mice had larger cerebral infarcts, the ischemia-induced enhancement of neurogenesis observed in wild-type mice was attenuated. These findings suggest that, in addition to its neurodevelopmental effects, Reln deficiency continues to influence neurogenesis and ischemic neuronal injury in the adult brain.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Reln  (reelin)

Genes (Mus musculus)
Reln  (reelin)

Genes (Homo sapiens)
RELN  (reelin)

Additional Information