RGD Reference Report - Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region. - Rat Genome Database

RGD Reference Report - Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region. - Rat Genome Database

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Improvement of memory and learning by intracerebroventricular microinjection of T3 in rat model of ischemic brain stroke mediated by upregulation of BDNF and GDNF in CA1 hippocampal region.
Authors:	Mokhtari, Tahmineh Akbari, Mohammad Malek, Fatemeh Kashani, Iraj Ragerdi Rastegar, Tayebeh Noorbakhsh, Farshid Ghazi-Khansari, Mahmoud Attari, Fatemeh Hassanzadeh, Gholamreza
Citation:	Mokhtari T, etal., Daru. 2017 Feb 15;25(1):4. doi: 10.1186/s40199-017-0169-x.
RGD ID:	405878057
Pubmed:	PMID:28202057 (View Abstract at PubMed)
PMCID:	PMC5312580 (View Article at PubMed Central)
DOI:	DOI:10.1186/s40199-017-0169-x (Journal Full-text)
BACKGROUND: Ischemic stroke is a common leading cause of death and disability with lack of effective therapies. In this study, T3 was intra-ventricularly injected to evaluate gene expression and protein concentration of and brain-derived neurotrophic factor (BDNF) and Glial cell-derived neurotrophic factor (GDNF) in hippocampal CA1 region in rat model of brain ischemia/reperfusion (I/R). METHODS: In this study, transient middle cerebral artery occlusion (tMCAo) was used as model of ischemic brain stroke. Rats were randomly divided in four groups of Co, Sh, tMCAo and tMCAo + T3. Then, a single dose of intra-ventricular T3 was administered via a Hamilton syringe. Passive avoidance test was used as behavioral investigations. After 21 days, the animals were sacrificed and their brains were used for molecular and histopathological studies. RESULTS: T3 significantly improved the learning and memory compared with tMCAo group according to Morris water maze findings (P < 0.05). Step-through latency (STL) significantly decreased in tMCAo group (P < 0.05). There were significant increase in the STL of T3 group compared with tMCAo group (P < 0.05).A significant reduction in BDNF mRNAs and protein levels were observed in the tMCAo compared with Co and Sh group (P < 0.05). A significant increase of BDNF and GDNF mRNAs and proteins was recorded in tMCAo + T3 group compared with Co, Sh and tMCAO groups (P < 0.05). CONCLUSIONS: The results of current study demonstrated that T3 had therapeutic effects on cerebral ischemic stroke by increasing the neurotrophic factors (BDNF, GDNF) in CA1 region of hippocampus. The effects of intracerebroventricular microinjection of T3on memory and learning in rat model of ischemic brain stroke.

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Object Symbol	Species	Term	Qualifier	Evidence	With	Notes	Source	Original Reference(s)
BDNF	Human	middle cerebral artery infarction	treatment	ISO	Bdnf (Rattus norvegicus)		RGD
Bdnf	Rat	middle cerebral artery infarction	treatment	IEP			RGD
Bdnf	Mouse	middle cerebral artery infarction	treatment	ISO	Bdnf (Rattus norvegicus)		RGD
GDNF	Human	middle cerebral artery infarction	treatment	ISO	Gdnf (Rattus norvegicus)		RGD
Gdnf	Rat	middle cerebral artery infarction	treatment	IEP			RGD
Gdnf	Mouse	middle cerebral artery infarction	treatment	ISO	Gdnf (Rattus norvegicus)		RGD

Genes (Rattus norvegicus)


Bdnf (brain-derived neurotrophic factor)	Gdnf (glial cell derived neurotrophic factor)

Genes (Mus musculus)


Bdnf (brain derived neurotrophic factor)	Gdnf (glial cell line derived neurotrophic factor)

Genes (Homo sapiens)


BDNF (brain derived neurotrophic factor)	GDNF (glial cell derived neurotrophic factor)