RGD Reference Report - Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat. - Rat Genome Database
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Induction of heat shock protein 40 and GrpE mRNAs following transient focal cerebral ischemia in the rat.

Authors: Tamura, S  Kinouchi, H  Izaki, K  Okubo, A  Sugawara, T  Kunizuka, H  Mizoi, K 
Citation: Tamura S, etal., Brain Res 2003 Jan 17;960(1-2):277-81.
RGD ID: 632868
Pubmed: (View Article at PubMed) PMID:12505684

Cerebral ischemia is associated with the induction of several heat shock proteins (HSPs), but the effects on HSP40 and GrpE are less clear. The present study investigated the induction of Hsp40 and GrpE mRNAs following 30 min of middle cerebral artery occlusion in the rat model. Reverse transcription-polymerase chain reaction (PCR) and in situ hybridization analyses showed significant induction of both mRNAs in the ischemic cortex. These results demonstrate the synergic induction of HSP70 molecular chaperone machinery in cerebral ischemia.

Annotation

Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Grpel1  (GrpE-like 1, mitochondrial)

Genes (Mus musculus)
Grpel1  (GrpE-like 1, mitochondrial)

Genes (Homo sapiens)
GRPEL1  (GrpE like 1, mitochondrial)


Additional Information