RGD Reference Report - Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex. - Rat Genome Database
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Growth-associated gene expression after stroke: evidence for a growth-promoting region in peri-infarct cortex.

Authors: Carmichael, ST  Archibeque, I  Luke, L  Nolan, T  Momiy, J  Li, S 
Citation: Carmichael ST, etal., Exp Neurol. 2005 Jun;193(2):291-311.
RGD ID: 9590118
Pubmed: (View Article at PubMed) PMID:15869933
DOI: Full-text: DOI:10.1016/j.expneurol.2005.01.004

Stroke induces axonal sprouting in peri-infarct cortex. A set of growth-associated genes important in axonal sprouting in peripheral nervous system regeneration and cortical development has recently been defined. The expression profiles of these growth-associated genes were defined during the post-stroke axonal sprouting response using a model of stroke in barrel field cortex. Stroke induces sequential waves of neuronal growth-promoting genes during the sprouting response: an early expression peak (SPRR1), a mid expression peak (p21, Ta1 tubulin, L1, MARCKS), a late peak (SCG10, SCLIP), and an early/sustained pattern (GAP43, CAP23, c-jun). These expression peaks correspond to specific time points in the sprouting response. The expression of the growth-inhibiting chondroitin sulfate proteoglycans aggrecan, brevican, versican, and phosphacan are induced late in the sprouting process; except neurocan, which is increased during the peak of the growth-promoting gene expression. The developmentally associated growth inhibitors ephrin-A5, ephB1, semaphorin IIIa, and neuropilin 1 are also induced in the early phases of the sprouting response. At the cellular level, chondroitin sulfate proteoglycans, in the form of peri-neuronal nets, are reduced in the region of axonal sprouting, during the peak of growth-promoting gene expression. These results identify a unique profile of growth-promoting gene expression in adult cortex after stroke, the inhibitory molecules that are present during the sprouting response, and a region in which growth-promoting genes are increased, growth-inhibitory proteins are diminished and axonal sprouting occurs. This region may be a growth-promoting zone after stroke.


Disease Annotations    

Objects Annotated

Genes (Rattus norvegicus)
Bcan  (brevican)
Ptprz1  (protein tyrosine phosphatase, receptor type Z1)

Genes (Mus musculus)
Bcan  (brevican)
Ptprz1  (protein tyrosine phosphatase, receptor type Z, polypeptide 1)

Genes (Homo sapiens)
BCAN  (brevican)
PTPRZ1  (protein tyrosine phosphatase receptor type Z1)

Additional Information