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ONTOLOGY REPORT - ANNOTATIONS


Term:middle cerebral artery infarction
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Accession:DOID:3525 term browser browse the term
Definition:NECROSIS occurring in the MIDDLE CEREBRAL ARTERY distribution system which brings blood to the entire lateral aspects of each CEREBRAL HEMISPHERE. Clinical signs include impaired cognition; APHASIA; AGRAPHIA; weak and numbness in the face and arms, contralaterally or bilaterally depending on the infarction.
Synonyms:exact_synonym: Cerebral Infarction, Middle Cerebral Artery;   Left Middle Cerebral Artery Infarction;   MCA Infarction;   MCAO;   Middle Cerebral Artery Circulation Infarction;   Middle Cerebral Artery Embolic Infarction;   Middle Cerebral Artery Embolus;   Middle Cerebral Artery Occlusion;   Middle Cerebral Artery Stroke;   Middle Cerebral Artery Syndrome;   Middle Cerebral Artery Thrombosis;   Middle Cerebral Artery Thrombotic Infarction;   Right Middle Cerebral Artery Infarction
 primary_id: MESH:D020244;   RDO:0007374
For additional species annotation, visit the Alliance of Genome Resources.


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middle cerebral artery infarction term browser
Symbol Object Name JBrowse Chr Start Stop Reference
G Abcc8 ATP binding cassette subfamily C member 8 JBrowse link 1 102,110,708 102,191,287 RGD:12790979
RGD:12791996
G Ace angiotensin I converting enzyme JBrowse link 10 94,170,766 94,213,831 RGD:11039026
G Ace2 angiotensin I converting enzyme 2 JBrowse link X 32,050,734 32,095,860 RGD:9685436
G Adora1 adenosine A1 receptor JBrowse link 13 51,042,111 51,076,913 RGD:11554173
G Ager advanced glycosylation end product-specific receptor JBrowse link 20 4,363,152 4,366,079 RGD:8696008
G Agt angiotensinogen JBrowse link 19 57,321,594 57,333,460 RGD:9685436
G Aifm1 apoptosis inducing factor, mitochondria associated 1 JBrowse link X 135,304,063 135,343,062 RGD:10047403
G Ak1 adenylate kinase 1 JBrowse link 3 11,652,143 11,659,135 RGD:5508760
G Alb albumin JBrowse link 14 19,176,275 19,191,793 RGD:11036100
G Alox5 arachidonate 5-lipoxygenase JBrowse link 4 148,398,004 148,446,308 RGD:11554173
G Ap2b1 adaptor related protein complex 2 subunit beta 1 JBrowse link 10 70,516,462 70,621,973 RGD:13461853
G Apaf1 apoptotic peptidase activating factor 1 JBrowse link 7 31,699,309 31,784,192 RGD:13703113
G Apoe apolipoprotein E JBrowse link 1 80,612,894 80,616,820 RGD:6903926
G App amyloid beta precursor protein JBrowse link 11 24,425,013 24,641,872 RGD:13782054
G Aqp4 aquaporin 4 JBrowse link 18 6,766,009 6,782,757 RGD:8695955
G Arc activity-regulated cytoskeleton-associated protein JBrowse link 7 115,907,097 115,911,059 RGD:10395314
G Atf3 activating transcription factor 3 JBrowse link 13 109,817,892 109,849,632 RGD:11554173
G Bad BCL2-associated agonist of cell death JBrowse link 1 222,198,516 222,207,459 RGD:10053665
RGD:10053704
G Bax BCL2 associated X, apoptosis regulator JBrowse link 1 101,451,801 101,457,207 RGD:10054501
G Bcan brevican JBrowse link 2 187,359,674 187,373,133 RGD:9590118
G Bcl2 BCL2, apoptosis regulator JBrowse link 13 26,605,426 26,769,374 RGD:10054501
G Bdnf brain-derived neurotrophic factor JBrowse link 3 100,768,637 100,819,216 RGD:4891138
G Becn1 beclin 1 JBrowse link 10 89,209,944 89,225,297 RGD:11561900
G Bnip3 BCL2 interacting protein 3 JBrowse link 1 211,248,098 211,265,282 RGD:9685412
G Bnip3l BCL2 interacting protein 3 like JBrowse link 15 43,643,897 43,667,123 RGD:2314138
RGD:9068917
G C3 complement C3 JBrowse link 9 9,721,137 9,747,084 RGD:7175514
RGD:11554173
G Camk2a calcium/calmodulin-dependent protein kinase II alpha JBrowse link 18 56,193,978 56,295,869 RGD:1358416
G Casp3 caspase 3 JBrowse link 16 48,845,011 48,863,249 RGD:10053704
RGD:13782346
RGD:10054501
G Casp6 caspase 6 JBrowse link 2 235,341,326 235,353,715 RGD:13782346
G Casp9 caspase 9 JBrowse link 5 160,356,211 160,373,774 RGD:13782346
G Ccl2 C-C motif chemokine ligand 2 JBrowse link 10 69,412,065 69,413,863 RGD:11554173
G Ccl7 C-C motif chemokine ligand 7 JBrowse link 10 69,423,083 69,424,933 RGD:11554173
G Cd36 CD36 molecule JBrowse link 4 14,150,309 14,191,498 RGD:11041113
G Cd86 CD86 molecule JBrowse link 11 67,060,305 67,117,990 RGD:2313025
G Cdk5 cyclin-dependent kinase 5 JBrowse link 4 7,282,945 7,287,427 RGD:13782375
G Cldn5 claudin 5 JBrowse link 11 86,356,292 86,357,718 RGD:13204729
G Crh corticotropin releasing hormone JBrowse link 2 104,459,999 104,461,863 RGD:5490538
G Crp C-reactive protein JBrowse link 13 91,080,448 91,081,358 RGD:9585995
G Crtc1 CREB regulated transcription coactivator 1 JBrowse link 16 20,740,746 20,798,145 RGD:4891138
G Csf3 colony stimulating factor 3 JBrowse link 10 86,616,785 86,619,160 RGD:11039420
RGD:11039425
G Cxcl10 C-X-C motif chemokine ligand 10 JBrowse link 14 17,210,733 17,212,930 RGD:632989
G Cxcl2 C-X-C motif chemokine ligand 2 JBrowse link 14 18,731,346 18,733,391 RGD:11554173
G Cxcr2 C-X-C motif chemokine receptor 2 JBrowse link 9 81,427,275 81,435,065 RGD:11554173
G Cxcr3 C-X-C motif chemokine receptor 3 JBrowse link X 71,614,346 71,616,997 RGD:632989
G Cyp2e1 cytochrome P450, family 2, subfamily e, polypeptide 1 JBrowse link 1 213,511,892 213,522,195 RGD:14700877
G Dnmt1 DNA methyltransferase 1 JBrowse link 8 21,922,515 21,968,495 RGD:9588643
G Dnmt3a DNA methyltransferase 3 alpha JBrowse link 6 28,205,375 28,346,052 RGD:9589049
G Dynll1 dynein light chain LC8-type 1 JBrowse link 12 47,074,200 47,076,573 RGD:13208524
G Edn1 endothelin 1 JBrowse link 17 22,136,814 22,143,745 RGD:11554173
G Egr1 early growth response 1 JBrowse link 18 27,657,903 27,660,101 RGD:10395314
G Egr2 early growth response 2 JBrowse link 20 22,452,170 22,461,018 RGD:10395314
G Egr4 early growth response 4 JBrowse link 4 117,293,620 117,296,082 RGD:10395314
G Eif2s1 eukaryotic translation initiation factor 2 subunit alpha JBrowse link 6 102,048,372 102,073,041 RGD:10395346
RGD:10755569
G Elane elastase, neutrophil expressed JBrowse link 7 12,638,320 12,640,168 RGD:10450546
G Eng endoglin JBrowse link 3 11,679,530 11,717,486 RGD:11041171
G Epcam epithelial cell adhesion molecule JBrowse link 6 11,282,194 11,308,870 RGD:11038820
G Epn1 Epsin 1 JBrowse link 1 72,294,153 72,310,217 RGD:13461853
G Epo erythropoietin JBrowse link 12 22,274,828 22,278,268 RGD:10400898
RGD:10401066
G Ercc6 ERCC excision repair 6, chromatin remodeling factor JBrowse link 16 8,734,028 8,804,610 RGD:10401103
G F11 coagulation factor XI JBrowse link 16 50,179,458 50,201,644 RGD:11041786
G F12 coagulation factor XII JBrowse link 17 9,736,577 9,744,420 RGD:11041786
G Fadd Fas associated via death domain JBrowse link 1 217,746,176 217,748,581 RGD:11341807
RGD:11344885
G Fgf21 fibroblast growth factor 21 JBrowse link 1 101,595,579 101,596,822 RGD:11554173
G Fos Fos proto-oncogene, AP-1 transcription factor subunit JBrowse link 6 109,300,433 109,303,299 RGD:11554173
G Gabra6 gamma-aminobutyric acid type A receptor alpha 6 subunit JBrowse link 10 27,847,447 27,862,896 RGD:11554173
G Gapdh glyceraldehyde-3-phosphate dehydrogenase JBrowse link 4 157,676,336 157,680,322 RGD:13792686
G Ghrl ghrelin and obestatin prepropeptide JBrowse link 4 145,674,157 145,678,066 RGD:9850083
G Ghsr growth hormone secretagogue receptor JBrowse link 2 113,065,953 113,071,265 RGD:9850083
G Grin1 glutamate ionotropic receptor NMDA type subunit 1 JBrowse link 3 2,507,745 2,534,664 RGD:11068571
G Grn granulin precursor JBrowse link 10 90,377,103 90,383,207 RGD:10401661
G Grpel1 GrpE-like 1, mitochondrial JBrowse link 14 79,458,951 79,464,782 RGD:632868
G Gsk3b glycogen synthase kinase 3 beta JBrowse link 11 65,060,884 65,208,842 RGD:13792734
G Hamp hepcidin antimicrobial peptide JBrowse link 1 89,368,021 89,369,960 RGD:11041635
G Has2 hyaluronan synthase 2 JBrowse link 7 96,438,046 96,464,049 RGD:9588631
G Hdac4 histone deacetylase 4 JBrowse link 9 99,052,945 99,299,715 RGD:9681449
G Hdac5 histone deacetylase 5 JBrowse link 10 90,140,183 90,169,853 RGD:9681449
G Hdac9 histone deacetylase 9 JBrowse link 6 53,487,367 54,358,694 RGD:9681449
G Hif1a hypoxia inducible factor 1 subunit alpha JBrowse link 6 96,810,868 96,856,303 RGD:9068917
G Hmgb1 high mobility group box 1 JBrowse link 12 7,082,529 7,090,246 RGD:9681449
G Hmox1 heme oxygenase 1 JBrowse link 19 14,508,634 14,515,455 RGD:10755587
RGD:10755755
RGD:10755588
G Hp haptoglobin JBrowse link 19 42,096,255 42,100,805 RGD:7175514
G Hspa4 heat shock protein family A (Hsp70) member 4 JBrowse link 10 38,601,624 38,642,397 RGD:5688754
RGD:6218961
G Hspd1 heat shock protein family D (Hsp60) member 1 JBrowse link 9 61,680,529 61,691,202 RGD:11554173
G Htra2 HtrA serine peptidase 2 JBrowse link 4 113,883,671 113,886,833 RGD:2314385
RGD:5688372
G Hvcn1 hydrogen voltage-gated channel 1 JBrowse link 12 39,822,814 39,851,093 RGD:14985213
G Icam1 intercellular adhesion molecule 1 JBrowse link 8 22,035,287 22,047,049 RGD:11554173
G Igf1 insulin-like growth factor 1 JBrowse link 7 28,412,123 28,491,815 RGD:11554173
G Ikbkb inhibitor of nuclear factor kappa B kinase subunit beta JBrowse link 16 74,177,233 74,230,809 RGD:10045955
G Il11 interleukin 11 JBrowse link 1 72,636,959 72,643,255 RGD:11554173
G Il13 interleukin 13 JBrowse link 10 38,982,909 38,985,466 RGD:7204480
G Il1b interleukin 1 beta JBrowse link 3 121,876,256 121,882,637 RGD:7204480
RGD:13792833
RGD:11554173
RGD:10450594
G Il1rn interleukin 1 receptor antagonist JBrowse link 3 1,449,778 1,468,624 RGD:8551708
G Il22 interleukin 22 JBrowse link 7 61,236,037 61,240,502 RGD:11554173
G Il4 interleukin 4 JBrowse link 10 38,963,979 38,969,531 RGD:7204480
G Il5 interleukin 5 JBrowse link 10 39,066,716 39,069,587 RGD:7204480
G Il6 interleukin 6 JBrowse link 4 3,043,231 3,047,807 RGD:11554173
RGD:13792833
G Il6r interleukin 6 receptor JBrowse link 2 189,196,180 189,255,987 RGD:11554173
G Il6st interleukin 6 signal transducer JBrowse link 2 44,279,199 44,319,427 RGD:11554173
G Irf4 interferon regulatory factor 4 JBrowse link 17 34,886,746 34,905,191 RGD:11530061
G Junb JunB proto-oncogene, AP-1 transcription factor subunit JBrowse link 19 26,092,972 26,094,756 RGD:11554173
G Mag myelin-associated glycoprotein JBrowse link 1 89,345,325 89,360,905 RGD:9685232
G Mapk1 mitogen activated protein kinase 1 JBrowse link 11 88,203,863 88,273,301 RGD:13800881
G Mapk3 mitogen activated protein kinase 3 JBrowse link 1 198,192,773 198,198,975 RGD:13800881
G Mapt microtubule-associated protein tau JBrowse link 10 92,289,002 92,386,517 RGD:13800886
RGD:13800913
G Mmp9 matrix metallopeptidase 9 JBrowse link 3 161,413,410 161,421,473 RGD:11554173
RGD:13204729
G Mt3 metallothionein 3 JBrowse link 19 11,324,708 11,326,112 RGD:9685807
G Mtor mechanistic target of rapamycin kinase JBrowse link 5 165,263,813 165,373,967 RGD:10040971
RGD:10041016
RGD:10040974
G Nae1 NEDD8 activating enzyme E1 subunit 1 JBrowse link 19 653,510 680,378 RGD:13801046
G Nampt nicotinamide phosphoribosyltransferase JBrowse link 6 52,122,085 52,156,473 RGD:13781880
G Nfe2l2 nuclear factor, erythroid 2-like 2 JBrowse link 3 62,497,568 62,525,146 RGD:10412696
RGD:10412714
G Nfkbia NFKB inhibitor alpha JBrowse link 6 76,267,227 76,270,457 RGD:10413868
G Ngf nerve growth factor JBrowse link 2 204,886,158 204,939,523 RGD:11554173
G Ngfr nerve growth factor receptor JBrowse link 10 83,389,828 83,408,061 RGD:10413900
G Nod2 nucleotide-binding oligomerization domain containing 2 JBrowse link 19 19,342,061 19,389,366 RGD:13204729
G Nos2 nitric oxide synthase 2 JBrowse link 10 66,188,290 66,221,621 RGD:5508751
RGD:5509037
G Nqo1 NAD(P)H quinone dehydrogenase 1 JBrowse link 19 38,422,210 38,437,103 RGD:5133239
RGD:11035212
G Nrg1 neuregulin 1 JBrowse link 16 62,969,573 64,065,063 RGD:10449015
G Ogg1 8-oxoguanine DNA glycosylase JBrowse link 4 145,282,828 145,289,367 RGD:8657395
G Park7 Parkinsonism associated deglycase JBrowse link 5 167,982,438 168,004,724 RGD:13463450
G Parp1 poly (ADP-ribose) polymerase 1 JBrowse link 13 98,857,255 98,889,444 RGD:5683909
RGD:13792686
RGD:10054501
RGD:11073732
G Pawr pro-apoptotic WT1 regulator JBrowse link 7 51,273,764 51,353,700 RGD:9835380
RGD:9850083
RGD:9835381
G Pdgfra platelet derived growth factor receptor alpha JBrowse link 14 35,527,926 35,581,130 RGD:11084934
G Pdgfrb platelet derived growth factor receptor beta JBrowse link 18 56,364,586 56,406,381 RGD:11084934
G Plat plasminogen activator, tissue type JBrowse link 16 74,098,263 74,122,897 RGD:1580876
RGD:11554173
G Plau plasminogen activator, urokinase JBrowse link 15 3,644,296 3,650,765 RGD:11554173
G Pld1 phospholipase D1 JBrowse link 2 113,651,967 113,849,403 RGD:11554173
G Prkcg protein kinase C, gamma JBrowse link 1 64,407,098 64,433,698 RGD:1358416
G Proc protein C, inactivator of coagulation factors Va and VIIIa JBrowse link 18 24,918,402 24,928,822 RGD:11100027
G Ptprz1 protein tyrosine phosphatase, receptor type Z1 JBrowse link 4 49,941,046 50,140,764 RGD:9590118
G Reln reelin JBrowse link 4 9,347,533 9,774,257 RGD:13207538
G Rgma repulsive guidance molecule BMP co-receptor a JBrowse link 1 134,699,053 134,742,512 RGD:9850121
RGD:9850122
G Rpl28 ribosomal protein L28 JBrowse link 1 72,619,282 72,621,941 RGD:6480229
G Runx1 RUNX family transcription factor 1 JBrowse link 11 32,765,147 33,003,061 RGD:11251714
G S100a5 S100 calcium binding protein A5 JBrowse link 2 189,999,669 190,005,877 RGD:11554173
G Serpine1 serpin family E member 1 JBrowse link 12 22,641,104 22,651,482 RGD:1580876
G Serpinf1 serpin family F member 1 JBrowse link 10 62,241,750 62,254,145 RGD:8655545
G Serpinh1 serpin family H member 1 JBrowse link 1 164,301,010 164,308,306 RGD:11554173
G Shh sonic hedgehog signaling molecule JBrowse link 4 718,538 727,691 RGD:12879461
G Sirt1 sirtuin 1 JBrowse link 20 26,831,971 26,851,587 RGD:9585664
G Slc12a2 solute carrier family 12 member 2 JBrowse link 18 52,917,124 52,985,281 RGD:1580583
RGD:14398833
G Slc2a1 solute carrier family 2 member 1 JBrowse link 5 138,154,677 138,182,897 RGD:12879855
G Slc9a1 solute carrier family 9 member A1 JBrowse link 5 151,573,122 151,626,360 RGD:14985213
G Slpi secretory leukocyte peptidase inhibitor JBrowse link 3 160,799,979 160,802,228 RGD:9999390
G Smo smoothened, frizzled class receptor JBrowse link 4 57,019,941 57,041,779 RGD:12832759
RGD:12879404
G Smox spermine oxidase JBrowse link 3 124,068,796 124,103,726 RGD:11554173
G Snap91 synaptosome associated protein 91 JBrowse link 8 94,447,558 94,564,772 RGD:13461853
G Sod1 superoxide dismutase 1 JBrowse link 11 30,363,282 30,368,858 RGD:8657021
RGD:8657023
G Sod2 superoxide dismutase 2 JBrowse link 1 47,914,757 47,921,587 RGD:11554173
G Sphk2 sphingosine kinase 2 JBrowse link 1 101,692,972 101,700,604 RGD:11554173
G Stat3 signal transducer and activator of transcription 3 JBrowse link 10 88,790,401 88,842,263 RGD:11554173
G Th tyrosine hydroxylase JBrowse link 1 216,073,034 216,080,287 RGD:5128609
G Tnf tumor necrosis factor JBrowse link 20 5,189,382 5,192,000 RGD:10450594
RGD:13825261
RGD:13792833
G Tnfaip6 TNF alpha induced protein 6 JBrowse link 3 37,545,238 37,564,704 RGD:11554173
G Tnfrsf1a TNF receptor superfamily member 1A JBrowse link 4 157,864,905 157,877,634 RGD:13825261
G Upp1 uridine phosphorylase 1 JBrowse link 14 89,314,234 89,334,060 RGD:2317094
G Xdh xanthine dehydrogenase JBrowse link 6 25,149,570 25,211,273 RGD:11554173

Term paths to the root
Path 1
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      cardiovascular system disease 4277
        vascular disease 3309
          artery disease 2187
            cerebral arterial disease 190
              middle cerebral artery infarction 156
Path 2
Term Annotations click to browse term
  disease 15619
    disease of anatomical entity 14948
      nervous system disease 10216
        central nervous system disease 8092
          brain disease 7561
            cerebrovascular disease 803
              brain ischemia 515
                brain infarction 223
                  cerebral infarction 199
                    middle cerebral artery infarction 156
paths to the root

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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.