RGD Reference Report - MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1. - Rat Genome Database

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MicroRNA-107 contributes to post-stroke angiogenesis by targeting Dicer-1.

Authors: Li, Y  Mao, L  Gao, Y  Baral, S  Zhou, Y  Hu, B 
Citation: Li Y, etal., Sci Rep. 2015 Aug 21;5:13316. doi: 10.1038/srep13316.
RGD ID: 11553310
Pubmed: PMID:26294080   (View Abstract at PubMed)
PMCID: PMC4543985   (View Article at PubMed Central)
DOI: DOI:10.1038/srep13316   (Journal Full-text)

Previous studies have suggested that microRNA-107 (miR-107) regulates cell migration in tumor and promotes Hypoxia Inducible Factor 1alpha (HIF1alpha) regulated angiogenesis under hypoxia. We found that miR-107 was strongly expressed in ischemic boundary zone (IBZ) after permanent middle cerebral artery occlusion (pMCAO) in rats and inhibition of miR-107 could reduce capillary density in the IBZ after stroke. Such finding led us to hypothesize that miR-107 might regulate post-stroke angiogenesis and therefore serve as a therapeutic target. We also found that antagomir-107, a synthetic miR-107 inhibitor, decreased the number of capillaries in IBZ and increased overall infarct volume after pMCAO in rats. We demonstrated that miR-107 could directly down-regulate Dicer-1, a gene that encodes an enzyme essential for processing microRNA (miRNA) precursors. This resulted in translational desupression of VEGF (vascular endothelial growth factor) mRNA, thereby increasing expression of endothelial cell-derived VEGF (VEGF165/VEGF164), leading to angiogenesis after stroke. This process might be a protective mechanism for ischemia-induced cerebral injury and miR-107 might be used as a novel tool in stroke treatment.

Disease Annotations    

Gene Ontology Annotations    

Biological Process

Objects Annotated

Genes (Rattus norvegicus)
Dicer1  (dicer 1 ribonuclease III)
Mir107  (microRNA 107)

Genes (Mus musculus)
Dicer1  (dicer 1, ribonuclease type III)
Mir107  (microRNA 107)

Genes (Homo sapiens)
DICER1  (dicer 1, ribonuclease III)
MIR107  (microRNA 107)

Additional Information