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RGD DISEASE ONTOLOGY - ANNOTATIONS

RGD uses the Human Disease Ontology (DO, https://disease-ontology.org/) for disease curation across species. RGD automatically downloads each new release of the ontology on a monthly basis. Some additional terms which are required for RGD's curation purposes but are not currently covered in the official version of DO have been added. As corresponding terms are added to DO, these custom terms are retired and the DO terms substituted in existing annotations and subsequently used for curation.
Term:atherosclerosis
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Accession:DOID:1936 term browser browse the term
Definition:A thickening and loss of elasticity of the walls of ARTERIES that occurs with formation of ATHEROSCLEROTIC PLAQUES within the ARTERIAL INTIMA. (DO)
Synonyms:exact_synonym: ALP;   ATHEROGENIC LIPOPROTEIN PHENOTYPE;   ATHEROSCLEROSIS SUSCEPTIBILITY;   ATHS;   Atherogenesis;   Atheroscleroses;   Atherosclerosis, Susceptibility To
 primary_id: MESH:D050197
 alt_id: MIM:108725
 xref: EFO:0003914;   ICD10CM:I70;   ICD9CM:440;   NCI:C35768;   NCI:C35771
For additional species annotation, visit the Alliance of Genome Resources.


show annotations for term's descendants           Sort by:
atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:22022523 PMID:29593532 RGD:401827839 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Abcg1 ATP binding cassette subfamily G member 1 treatment ISO RGD PMID:23650230 RGD:401842363 NCBI chr20:9,126,687...9,182,948
Ensembl chr20:9,126,687...9,182,948 		JBrowse link
G Abcg5 ATP binding cassette subfamily G member 5 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11138003 PMID:29593532 RGD:401827839 NCBI chr 6:9,965,118...9,990,563
Ensembl chr 6:9,965,118...9,990,563 		JBrowse link
G Abcg8 ATP binding cassette subfamily G member 8 treatment ISO RGD PMID:29593532 RGD:401827839 NCBI chr 6:9,945,629...9,964,912
Ensembl chr 6:9,945,629...9,964,912 		JBrowse link
G Acaca acetyl-CoA carboxylase alpha treatment ISO RGD PMID:33011372 RGD:401842381 NCBI chr10:69,014,261...69,276,453
Ensembl chr10:69,014,170...69,276,457 		JBrowse link
G Add1 adducin 1 ISO DNA:missense mutation:cds:p.G460W (human) RGD PMID:17082469 RGD:5147995 NCBI chr14:76,108,643...76,167,267
Ensembl chr14:76,108,654...76,167,182 		JBrowse link
G Adipoq adiponectin, C1Q and collagen domain containing treatment ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:18931039 PMID:12451000 RGD:8694473 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G Ager advanced glycosylation end product-specific receptor treatment ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with Kidney Failure, Chronic; protein:decreased expression:plasma (human)		 CTD
RGD		 PMID:19939336 PMID:20372816 PMID:22552116 PMID:23936343 PMID:22038096 More... RGD:6784514, RGD:8695994, RGD:7245947, RGD:6767557, RGD:6784516, RGD:6784515 NCBI chr20:4,148,150...4,151,361
Ensembl chr20:4,147,890...4,151,078 		JBrowse link
G Agt angiotensinogen treatment IMP
ISO		 associated with Hypertension
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21925196 PMID:22539767 PMID:22977667 RGD:8549467 NCBI chr19:52,529,139...52,549,618
Ensembl chr19:52,529,185...52,540,977 		JBrowse link
G Ahr aryl hydrocarbon receptor ISO CTD Direct Evidence: marker/mechanism CTD PMID:22228805 NCBI chr 6:52,234,089...52,271,568
Ensembl chr 6:52,234,089...52,271,568 		JBrowse link
G Akt1 AKT serine/threonine kinase 1 severity ISO RGD PMID:18054314 RGD:5509083 NCBI chr 6:131,713,716...131,735,319
Ensembl chr 6:131,713,720...131,733,921 		JBrowse link
G Alox15 arachidonate 15-lipoxygenase ISO CTD Direct Evidence: therapeutic CTD
RGD		 PMID:16303615 PMID:18206890 RGD:5509610 NCBI chr10:55,060,169...55,068,885
Ensembl chr10:55,060,412...55,068,874 		JBrowse link
G Alox5 arachidonate 5-lipoxygenase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16698924 NCBI chr 4:149,531,329...149,578,696
Ensembl chr 4:149,531,515...149,578,743 		JBrowse link
G Alox5ap arachidonate 5-lipoxygenase activating protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:16698924 NCBI chr12:5,748,941...5,772,986
Ensembl chr12:5,748,944...5,772,986 		JBrowse link
G Apoa1 apolipoprotein A1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:33861588 PMID:18287885 PMID:23078847 RGD:7241575, RGD:7241852 NCBI chr 8:46,527,251...46,529,035
Ensembl chr 8:46,527,144...46,529,035 		JBrowse link
G Apoa4 apolipoprotein A4 ISO CTD Direct Evidence: therapeutic CTD PMID:15822908 NCBI chr 8:46,539,083...46,541,464
Ensembl chr 8:46,539,082...46,541,469 		JBrowse link
G Apoe apolipoprotein E treatment ISO
IMP		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:9169506 PMID:9409251 PMID:9649566 PMID:11095717 PMID:11231916 More... RGD:734968, RGD:150521536, RGD:7771549 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Bcl2 BCL2, apoptosis regulator IEP associated with type 2 diabetes mellitus; mRNA, protein:increased expression:thoracic aorta (rat) RGD PMID:33889291 RGD:329849122 NCBI chr13:22,689,783...22,853,920
Ensembl chr13:22,684,989...22,853,743
Ensembl chr13:22,684,989...22,853,743 		JBrowse link
G Bcl3 BCL3, transcription coactivator ISO CTD Direct Evidence: marker/mechanism CTD PMID:25374339 NCBI chr 1:79,471,368...79,485,908
Ensembl chr 1:79,471,369...79,485,607 		JBrowse link
G Carmn cardiac mesoderm enhancer-associated non-coding RNA disease_progression ISO RNA:decreased expression:carotid artery RGD PMID:34289702 PMID:34289702 RGD:155882579, RGD:155882579 NCBI chr18:55,097,848...55,118,769
Ensembl chr18:55,095,230...55,118,825 		JBrowse link
G Casp3 caspase 3 treatment IEP associated with type 2 diabetes mellitus RGD PMID:29213335 RGD:13792600 NCBI chr16:45,662,910...45,681,171
Ensembl chr16:45,662,910...45,684,648 		JBrowse link
G Casr calcium-sensing receptor ISO
IEP		 protein:decreased expression:tibial artery (human)
protein:increased expression:myocardium (rat)		 RGD PMID:18852253 PMID:22527939 RGD:7205454, RGD:7205672 NCBI chr11:64,235,251...64,304,811
Ensembl chr11:64,235,251...64,304,811 		JBrowse link
G Cav1 caveolin 1 treatment IEP RGD PMID:23675421 RGD:8662275 NCBI chr 4:45,640,624...45,673,708
Ensembl chr 4:45,634,918...45,673,705 		JBrowse link
G Ccl2 C-C motif chemokine ligand 2 treatment
severity		 ISO CTD Direct Evidence: marker/mechanism
mRNA:increased expression:aorta (mouse)		 CTD
RGD		 PMID:12677255 PMID:12928151 PMID:20720404 PMID:11486244 PMID:23650230 More... RGD:8548896, RGD:401842363, RGD:7401235 NCBI chr10:67,005,424...67,007,222
Ensembl chr10:67,005,424...67,007,226 		JBrowse link
G Ccl3 C-C motif chemokine ligand 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24370436 NCBI chr10:68,451,388...68,452,938
Ensembl chr10:68,451,388...68,452,938 		JBrowse link
G Ccl4 C-C motif chemokine ligand 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:24370436 NCBI chr10:68,466,394...68,468,229
Ensembl chr10:68,452,052...68,468,231 		JBrowse link
G Ccl5 C-C motif chemokine ligand 5 ameliorates ISO RGD PMID:19122657 RGD:329901820 NCBI chr10:68,322,826...68,327,380
Ensembl chr10:68,322,829...68,327,377 		JBrowse link
G Ccn1 cellular communication network factor 1 ameliorates ISO ApoE knockout mouse RGD PMID:30917686 RGD:329845559 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Ccnd1 cyclin D1 IEP associated with type 2 diabetes mellitus; mRNA, protein:increased expression:thoracic aorta (rat) RGD PMID:33889291 RGD:329849122 NCBI chr 1:200,089,002...200,098,524
Ensembl chr 1:200,089,002...200,098,602 		JBrowse link
G Ccr5 C-C motif chemokine receptor 5 treatment ISO RGD PMID:16763157 RGD:8549763 NCBI chr 8:123,752,423...123,757,538
Ensembl chr 8:123,752,325...123,759,260 		JBrowse link
G Ccr6 C-C motif chemokine receptor 6 ISO RGD PMID:24114205 RGD:7483610 NCBI chr 1:52,474,477...52,508,301
Ensembl chr 1:52,474,168...52,498,603 		JBrowse link
G Cd36 CD36 molecule treatment ISO
IEP		 RGD PMID:19264766 PMID:26003171 PMID:20037584 RGD:6893502, RGD:11041151, RGD:6893559 NCBI chr 4:17,317,343...17,410,084
Ensembl chr 4:17,354,466...17,513,903 		JBrowse link
G Cd40 CD40 molecule treatment ISO
IDA
IEP		 associated with Gram-Negative Bacterial Infections;protein:increased expression:aorta
associated with Hypercholesterolemia		 RGD PMID:20505314 PMID:23984971 PMID:23984971 PMID:16317521 RGD:5490534, RGD:8547801, RGD:8547801, RGD:1582628 NCBI chr 3:153,790,372...153,805,279
Ensembl chr 3:153,790,449...153,805,534 		JBrowse link
G Cd40lg CD40 ligand treatment ISO
IDA
IEP		 associated with Hypercholesterolemia
protein:increased expression:plasma		 RGD PMID:20705757 PMID:26261622 PMID:23984971 PMID:16317521 PMID:21817131 RGD:5490529, RGD:11344965, RGD:8547801, RGD:1582628, RGD:7248421 NCBI chr  X:135,127,052...135,138,768
Ensembl chr  X:135,126,969...135,138,306 		JBrowse link
G Cela2a chymotrypsin like elastase 2A ISO CTD Direct Evidence: marker/mechanism CTD PMID:31358993 NCBI chr 5:154,126,879...154,136,630
Ensembl chr 5:154,126,878...154,136,632 		JBrowse link
G Clu clusterin treatment IDA RGD PMID:15961700 RGD:9068390 NCBI chr15:40,161,068...40,200,315
Ensembl chr15:40,174,617...40,200,315 		JBrowse link
G Cnr2 cannabinoid receptor 2 ISO CTD Direct Evidence: therapeutic CTD PMID:15815632 NCBI chr 5:148,125,222...148,151,548
Ensembl chr 5:148,125,604...148,151,548 		JBrowse link
G Col4a2 collagen type IV alpha 2 chain susceptibility ISO DNA:SNP: :rs72657934(human) RGD PMID:28642624 RGD:13450936 NCBI chr16:78,047,591...78,183,360
Ensembl chr16:78,047,602...78,183,839 		JBrowse link
G Cpe carboxypeptidase E ISO mRNA:decreased expression:carotid plaque (human) RGD PMID:30305673 RGD:405650671 NCBI chr16:25,030,276...25,142,231
Ensembl chr16:25,030,276...25,142,233 		JBrowse link
G Cpt1a carnitine palmitoyltransferase 1A treatment ISO RGD PMID:23650230 RGD:401842363 NCBI chr 1:200,564,634...200,627,059
Ensembl chr 1:200,565,613...200,627,055 		JBrowse link
G Crp C-reactive protein disease_progression ISO protein:increased expression:serum:
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:16931792 PMID:18535598 RGD:9491769 NCBI chr13:85,135,384...85,175,178
Ensembl chr13:85,124,977...85,175,178 		JBrowse link
G Csf1 colony stimulating factor 1 ISO protein:increased expression:plasma (mouse)
associated with Kidney Failure, Chronic		 RGD PMID:9637704 PMID:16166801 RGD:734837, RGD:7257575 NCBI chr 2:195,377,215...195,396,608
Ensembl chr 2:195,377,215...195,411,704 		JBrowse link
G Ctnnb1 catenin beta 1 ameliorates ISO RGD PMID:35854140 RGD:242905195 NCBI chr 8:120,640,008...120,667,110
Ensembl chr 8:120,639,995...120,667,111 		JBrowse link
G Ctsb cathepsin B ISO RGD PMID:12213722 RGD:5687152 NCBI chr15:37,389,636...37,410,508
Ensembl chr15:37,389,629...37,410,500 		JBrowse link
G Ctsd cathepsin D ISO RGD PMID:12213722 RGD:5687152 NCBI chr 1:197,527,467...197,539,343
Ensembl chr 1:197,527,467...197,539,488 		JBrowse link
G Ctsl cathepsin L ISO RGD PMID:12213722 RGD:5687152 NCBI chr17:764,370...770,533
Ensembl chr17:764,309...770,548 		JBrowse link
G Ctss cathepsin S ISO RGD PMID:12213722 RGD:5687152 NCBI chr 2:183,086,437...183,114,483
Ensembl chr 2:183,086,437...183,114,483 		JBrowse link
G Cx3cr1 C-X3-C motif chemokine receptor 1 ISO RGD PMID:23887641 RGD:9479739 NCBI chr 8:119,785,726...119,799,431
Ensembl chr 8:119,782,595...119,800,014 		JBrowse link
G Cyba cytochrome b-245 alpha chain ISO CTD Direct Evidence: marker/mechanism CTD PMID:20720404 NCBI chr19:50,487,598...50,495,669
Ensembl chr19:50,487,597...50,495,721 		JBrowse link
G Cyp27a1 cytochrome P450, family 27, subfamily a, polypeptide 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11166758 PMID:19801147 NCBI chr 9:76,264,655...76,294,551
Ensembl chr 9:76,264,860...76,294,551 		JBrowse link
G Dab2ip DAB2 interacting protein ISO protein:alternative forms:coronary artery (human) RGD PMID:31619063 RGD:401938615 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Dll4 delta like canonical Notch ligand 4 ameliorates
treatment		 ISO RGD PMID:22699504 PMID:30909142 RGD:155641244, RGD:155663380 NCBI chr 3:106,317,114...106,327,004
Ensembl chr 3:106,316,986...106,326,931 		JBrowse link
G Dusp5 dual specificity phosphatase 5 ameliorates ISO ApoE knockout mice RGD PMID:30529164 RGD:243048424 NCBI chr 1:252,538,408...252,555,320
Ensembl chr 1:252,538,449...252,551,818 		JBrowse link
G Edn1 endothelin 1 treatment ISO RGD PMID:16806235 RGD:8661682 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Egln1 egl-9 family hypoxia-inducible factor 1 treatment ISO RGD PMID:26848160 RGD:11251766 NCBI chr19:52,867,900...52,907,308
Ensembl chr19:52,869,486...52,907,777 		JBrowse link
G Elovl5 ELOVL fatty acid elongase 5 treatment ISO RGD PMID:29593532 RGD:401827839 NCBI chr 8:78,790,846...78,857,307
Ensembl chr 8:78,790,846...78,857,284 		JBrowse link
G Ephx2 epoxide hydrolase 2 ISO RGD PMID:20224052 RGD:5688357 NCBI chr15:40,289,901...40,327,632
Ensembl chr15:40,289,902...40,327,615 		JBrowse link
G Esr1 estrogen receptor 1 treatment ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:11894143 PMID:11160157 RGD:8553067 NCBI chr 1:41,106,335...41,499,104
Ensembl chr 1:41,210,475...41,495,002 		JBrowse link
G Esr2 estrogen receptor 2 ISO RGD PMID:21697723 RGD:5508792 NCBI chr 6:94,858,438...94,909,630
Ensembl chr 6:94,809,547...94,908,919 		JBrowse link
G F11r F11 receptor ISO mRNA:increased expression:carotid artery RGD PMID:15681301 RGD:7488921 NCBI chr13:83,873,797...83,897,388
Ensembl chr13:83,873,797...83,897,402 		JBrowse link
G F2 coagulation factor II, thrombin treatment IDA RGD PMID:20979870 RGD:7387315 NCBI chr 3:77,596,196...77,609,486
Ensembl chr 3:77,596,198...77,609,486 		JBrowse link
G Fas Fas cell surface death receptor treatment IEP
ISO		 associated with type 2 diabetes mellitus RGD PMID:29213335 PMID:29593532 RGD:13792600, RGD:401827839 NCBI chr 1:231,798,963...231,832,591
Ensembl chr 1:231,798,960...231,832,591 		JBrowse link
G Faslg Fas ligand ISO CTD Direct Evidence: marker/mechanism CTD PMID:15063428 NCBI chr13:74,151,519...74,172,760
Ensembl chr13:74,154,954...74,162,215 		JBrowse link
G Fcgr2a Fc gamma receptor 2A onset ISO DNA:polymorphism: :p.H131R (human) RGD PMID:19490059 RGD:5147923 NCBI chr13:83,280,782...83,297,535
Ensembl chr13:83,280,784...83,295,967 		JBrowse link
G Fcgr2b Fc gamma receptor 2B ISO RGD PMID:17053192 RGD:7240526 NCBI chr13:83,191,253...83,207,778
Ensembl chr13:83,193,163...83,207,778 		JBrowse link
G Fgf21 fibroblast growth factor 21 ISO associated with Diabetes Mellitus, Type 2;protein:increased expression:serum: RGD PMID:26047614 RGD:10401919 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fgfr2 fibroblast growth factor receptor 2 treatment ISO RGD PMID:24224032 RGD:155791446 NCBI chr 1:184,745,418...184,850,655
Ensembl chr 1:184,745,420...184,850,626 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase sexual_dimorphism ISO RGD PMID:28253220 RGD:329812017 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Gpx3 glutathione peroxidase 3 treatment IEP RGD PMID:21300352 RGD:401827830 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Grn granulin precursor ISO protein:increased expression:smooth muscle cell, macrophage RGD PMID:19321167 RGD:5509781 NCBI chr10:87,387,672...87,393,777
Ensembl chr10:87,387,638...87,393,775 		JBrowse link
G Gstm1 glutathione S-transferase mu 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19822795 NCBI chr 2:195,649,845...195,655,402
Ensembl chr 2:195,649,845...195,655,411 		JBrowse link
G H19 H19 imprinted maternally expressed transcript ameliorates ISO RNA:increased expression:blood serum (human)
ApoE knockout mice
ApoE���/��� mice
RNA:increased expression:blood plasm (human)		 RGD PMID:28165553 PMID:30529164 PMID:31757932 PMID:32945413 PMID:35854140 More... RGD:156430317, RGD:243048424, RGD:242905202, RGD:242905200, RGD:242905195, RGD:158013772, RGD:156430336 NCBI chr 1:197,730,698...197,733,374
Ensembl chr 1:197,730,698...197,733,134 		JBrowse link
G Haao 3-hydroxyanthranilate 3,4-dioxygenase treatment ISO Ldlr knockout mouse RGD PMID:31589306 RGD:243065123 NCBI chr 6:10,845,235...10,864,863
Ensembl chr 6:10,845,771...10,864,877 		JBrowse link
G Hdac4 histone deacetylase 4 ameliorates ISO RGD PMID:35854140 RGD:242905195 NCBI chr 9:92,503,467...92,750,164
Ensembl chr 9:92,507,611...92,750,164 		JBrowse link
G Hdac9 histone deacetylase 9 ISO CTD Direct Evidence: marker/mechanism CTD PMID:36322813 NCBI chr 6:50,762,074...51,624,311
Ensembl chr 6:50,763,590...51,625,333 		JBrowse link
G Hey1 hes-related family bHLH transcription factor with YRPW motif 1 treatment ISO RGD PMID:30909142 RGD:155663380 NCBI chr 2:93,096,605...93,100,316
Ensembl chr 2:93,095,498...93,100,312 		JBrowse link
G Hmgb1 high mobility group box 1 treatment IEP RGD PMID:20519084 RGD:10402182 NCBI chr12:5,972,950...5,979,658
Ensembl chr12:5,901,586...5,978,565
Ensembl chr16:5,901,586...5,978,565 		JBrowse link
G Hnrnpc heterogeneous nuclear ribonucleoprotein C ISO protein:increased expression:internal carotid artery, smooth muscle cell (human) RGD PMID:18508286 RGD:10054381 NCBI chr15:24,779,593...24,809,213
Ensembl chr15:24,779,450...24,809,183 		JBrowse link
G Hp haptoglobin treatment IEP
ISO		 CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:16597321 PMID:23665315 RGD:11041860 NCBI chr19:37,539,626...37,544,178
Ensembl chr19:37,539,627...37,544,523 		JBrowse link
G Hrh1 histamine receptor H 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:25020133 NCBI chr 4:147,564,963...147,649,353
Ensembl chr 4:147,645,995...147,647,455 		JBrowse link
G Hspa1a heat shock protein family A (Hsp70) member 1A ISO DNA:SNP:promoter:-110A>C(rs1008438) (human) RGD PMID:20490736 PMID:22328194 RGD:5147595, RGD:7257649 NCBI chr20:3,870,765...3,873,221
Ensembl chr20:3,856,006...3,873,227 		JBrowse link
G Hspa1b heat shock protein family A (Hsp70) member 1B ISO CTD Direct Evidence: marker/mechanism CTD PMID:16513158 NCBI chr20:3,855,104...3,859,148
Ensembl chr20:3,856,006...3,873,240
Ensembl chr20:3,856,006...3,873,240 		JBrowse link
G Icam1 intercellular adhesion molecule 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12677255 NCBI chr 8:19,553,063...19,565,438
Ensembl chr 8:19,553,645...19,565,438 		JBrowse link
G Ifng interferon gamma ISO CTD Direct Evidence: marker/mechanism CTD PMID:9169506 NCBI chr 7:53,903,339...53,907,375
Ensembl chr 7:53,903,337...53,907,375 		JBrowse link
G Igf2 insulin-like growth factor 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:11726660 NCBI chr 1:197,814,409...197,831,802
Ensembl chr 1:197,814,410...197,823,018 		JBrowse link
G Il10 interleukin 10 treatment ISO RGD PMID:29593532 RGD:401827839 NCBI chr13:42,472,625...42,477,308
Ensembl chr13:42,472,839...42,477,313 		JBrowse link
G Il17a interleukin 17A treatment ISO RGD PMID:21300351 RGD:9170237 NCBI chr 9:23,144,402...23,147,889
Ensembl chr 9:23,144,402...23,147,889 		JBrowse link
G Il18 interleukin 18 treatment IEP
ISO		 RGD PMID:23685195 PMID:16732281 RGD:8655997, RGD:14695532 NCBI chr 8:50,904,630...50,932,887
Ensembl chr 8:50,906,960...50,932,887 		JBrowse link
G Il1b interleukin 1 beta ameliorates ISO associated with Renal Insufficiency, Chronic RGD PMID:21245127 PMID:35854140 RGD:7175328, RGD:242905195 NCBI chr 3:116,577,005...116,583,386
Ensembl chr 3:116,577,010...116,583,415 		JBrowse link
G Il2 interleukin 2 ISO associated with Diabetes Mellitus, Type 1 RGD PMID:21606463 RGD:5147904 NCBI chr 2:120,004,862...120,009,566
Ensembl chr 2:120,004,862...120,009,566 		JBrowse link
G Il27 interleukin 27 ameliorates ISO RGD PMID:23729211 RGD:39456136 NCBI chr 1:181,173,108...181,178,720
Ensembl chr 1:181,173,372...181,178,582 		JBrowse link
G Il6 interleukin 6 treatment
ameliorates		 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:19330073 PMID:29593532 PMID:35854140 RGD:401827839, RGD:242905195 NCBI chr 4:5,214,602...5,219,178
Ensembl chr 4:5,213,394...5,219,178 		JBrowse link
G Itgam integrin subunit alpha M ameliorates ISO associated with Hypercholesterolemia;DNA:missense mutation:CDS:p.I332G (mouse)
mRNA:increased expression:peripheral blood mononuclear cell (human)
protein:increased expression:descending aorta (mouse)		 RGD PMID:32938725 PMID:24716741 PMID:30913515 RGD:329853755, RGD:329901833, RGD:329901661 NCBI chr 1:182,659,047...182,709,501
Ensembl chr 1:182,659,000...182,709,503 		JBrowse link
G Jak2 Janus kinase 2 IEP associated with type 2 diabetes mellitus; mRNA, protein:increased expression, increased phosphorylation:aorta, blood serum (rat) RGD PMID:33889291 RGD:329849122 NCBI chr 1:226,995,334...227,054,381
Ensembl chr 1:226,995,334...227,054,189 		JBrowse link
G Kcnn4 potassium calcium-activated channel subfamily N member 4 ameliorates ISO ApoE knockout mouse RGD PMID:18688283 RGD:329955454 NCBI chr 1:79,956,380...79,974,354
Ensembl chr 1:79,959,322...79,974,340 		JBrowse link
G Kdr kinase insert domain receptor treatment ISO RGD PMID:17303776 RGD:8551768 NCBI chr14:32,217,871...32,261,018
Ensembl chr14:32,217,871...32,261,018 		JBrowse link
G Khdrbs1 KH RNA binding domain containing, signal transduction associated 1 ameliorates ISO ApoE knockout mice RGD PMID:30529164 RGD:243048424 NCBI chr 5:142,051,844...142,089,175
Ensembl chr 5:142,063,570...142,089,180 		JBrowse link
G Kl Klotho ISO RGD PMID:11027545 RGD:10403056 NCBI chr12:490,402...531,417
Ensembl chr12:490,399...530,080 		JBrowse link
G Ldlr low density lipoprotein receptor ISO
IMP		 CTD Direct Evidence: marker/mechanism|therapeutic
DNA:mutation:exon:478T > A(rat)		 CTD
RGD		 PMID:11947894 PMID:18450471 PMID:22153697 PMID:25619500 PMID:28899902 More... RGD:5490255, RGD:12910105 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Lsm4 LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr16:18,755,481...18,761,106
Ensembl chr16:18,755,484...18,760,926 		JBrowse link
G Lta4h leukotriene A4 hydrolase ISO CTD Direct Evidence: marker/mechanism CTD PMID:16698924 NCBI chr 7:27,969,796...28,001,600
Ensembl chr 7:27,969,789...28,001,600 		JBrowse link
G Mir126b microRNA 126b exacerbates ISO RGD PMID:24584117 RGD:401850548 NCBI chr 3:9,415,087...9,415,159 JBrowse link
G Mir140 microRNA 140 ISO mRNA:increased expression:blood vessel (mouse)
miRNA:increased expression:artery (human)
miRNA:increased expression:peripheral monocytes (human)		 RGD PMID:30483753 PMID:33495827 PMID:32965005 RGD:329337368, RGD:329347823, RGD:329337370 NCBI chr19:35,465,577...35,465,675
Ensembl chr19:35,465,577...35,465,675 		JBrowse link
G Mir145 microRNA 145 ameliorates ISO RGD PMID:29710501 RGD:155260303 NCBI chr18:55,099,640...55,099,727
Ensembl chr18:55,099,640...55,099,727 		JBrowse link
G Mir146a microRNA 146a severity ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr10:27,848,516...27,848,610
Ensembl chr10:27,848,516...27,848,610 		JBrowse link
G Mir155 microRNA 155 treatment
severity		 ISO associated with Bacteremia
miRNA:decreased expression:peripheral blood mononuclear cell, plasma		 RGD PMID:28970282 PMID:28646427 PMID:31866771 PMID:27856635 RGD:21079445, RGD:24922209, RGD:21081515, RGD:21079446 NCBI chr11:23,774,654...23,774,718
Ensembl chr11:23,774,654...23,774,718 		JBrowse link
G Mir17 microRNA 17 treatment ISO RGD PMID:30850242 RGD:329349304 NCBI chr15:92,180,629...92,180,712
Ensembl chr15:92,180,629...92,180,712 		JBrowse link
G Mir20a microRNA 20a ameliorates ISO RGD PMID:35854140 RGD:242905195 NCBI chr15:92,181,084...92,181,168
Ensembl chr15:92,181,084...92,181,168 		JBrowse link
G Mir21 microRNA 21 severity ISO miRNA:increased expression:peripheral blood mononuclear cell, plasma RGD PMID:31866771 RGD:21081515 NCBI chr10:71,405,257...71,405,348
Ensembl chr10:71,405,257...71,405,348 		JBrowse link
G Mir223 microRNA 223 ISO RNA:increased expression:serum,artery RGD PMID:26065992 RGD:25824846 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Mmp1 matrix metallopeptidase 1 susceptibility ISO human gene in mouse model
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:21742783 PMID:11375412 RGD:7207025 NCBI chr 8:4,658,588...4,679,099
Ensembl chr 8:4,658,588...4,679,097 		JBrowse link
G Mmp2 matrix metallopeptidase 2 ameliorates
treatment		 IEP
ISO		 RGD PMID:16317521 PMID:31757932 PMID:20370796 RGD:1582628, RGD:242905202, RGD:8657031 NCBI chr19:14,154,657...14,182,870
Ensembl chr19:14,154,657...14,182,870 		JBrowse link
G Mpo myeloperoxidase ISO CTD Direct Evidence: marker/mechanism CTD PMID:33861588 NCBI chr10:72,594,883...72,608,862
Ensembl chr10:72,594,661...72,604,819 		JBrowse link
G Mrpl45 mitochondrial ribosomal protein L45 ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr10:82,308,650...82,320,474
Ensembl chr10:82,308,427...82,320,474 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase severity ISO associated with Kidney Failure, Chronic; DNA:transversion:cds:g.1298A>C (human) RGD PMID:17899317 RGD:6893579 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Mtor mechanistic target of rapamycin kinase ameliorates ISO ApoE knockout mice RGD PMID:30529164 RGD:243048424 NCBI chr 5:158,884,856...158,994,311
Ensembl chr 5:158,884,804...158,994,311 		JBrowse link
G Myc MYC proto-oncogene, bHLH transcription factor treatment ISO RGD PMID:35854140 RGD:242905195 NCBI chr 7:93,593,705...93,598,633
Ensembl chr 7:93,593,705...93,598,630 		JBrowse link
G Mylip myosin regulatory light chain interacting protein treatment ISO RGD PMID:29593532 RGD:401827839 NCBI chr17:19,286,649...19,308,295
Ensembl chr17:19,286,650...19,308,295 		JBrowse link
G Nectin2 nectin cell adhesion molecule 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:28062492 NCBI chr 1:79,372,123...79,407,379
Ensembl chr 1:79,372,119...79,407,360 		JBrowse link
G Ngf nerve growth factor ISO protein:decreased expression:coronary artery (human) RGD PMID:11689207 RGD:5508382 NCBI chr 2:189,901,058...189,954,452
Ensembl chr 2:189,901,058...189,954,452 		JBrowse link
G Ngfr nerve growth factor receptor ISO protein:increased expression:adventitia, vasa vasorum (human) RGD PMID:11689207 RGD:5508382 NCBI chr10:80,515,287...80,533,518
Ensembl chr10:80,515,299...80,533,518 		JBrowse link
G Nnmt nicotinamide N-methyltransferase disease_progression ISO protein:increased activity:liver (mouse) RGD PMID:19307695 RGD:401794447 NCBI chr 8:48,928,663...48,947,734
Ensembl chr 8:48,933,598...48,946,655 		JBrowse link
G Nod2 nucleotide-binding oligomerization domain containing 2 ISO RGD PMID:24324141 RGD:8158039 NCBI chr19:18,382,369...18,422,817
Ensembl chr19:18,382,439...18,417,177 		JBrowse link
G Nono non-POU domain containing, octamer-binding severity ISO mRNA, protein:increased expression:coronary artery (human) RGD PMID:29673854 PMID:33626912 RGD:155882449, RGD:155900763 NCBI chr  X:66,554,131...66,571,992
Ensembl chr  X:66,554,098...66,571,952 		JBrowse link
G Nos2 nitric oxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20720404 NCBI chr10:63,815,308...63,851,208
Ensembl chr10:63,815,308...63,851,210 		JBrowse link
G Nos3 nitric oxide synthase 3 susceptibility ISO DNA:snp:exon:c.894G>T (human)
CTD Direct Evidence: marker/mechanism|therapeutic		 CTD
RGD		 PMID:12677255 PMID:20720404 PMID:21114134 PMID:12163452 RGD:7771564, RGD:7771607 NCBI chr 4:10,793,834...10,814,170
Ensembl chr 4:10,793,834...10,814,166 		JBrowse link
G Notch1 notch receptor 1 treatment ISO RGD PMID:30909142 RGD:155663380 NCBI chr 3:9,277,955...9,323,531
Ensembl chr 3:9,278,086...9,323,531 		JBrowse link
G Npc1 NPC intracellular cholesterol transporter 1 ISO CTD Direct Evidence: therapeutic CTD PMID:18483620 NCBI chr18:3,379,482...3,425,100
Ensembl chr18:3,379,482...3,425,049 		JBrowse link
G Nppb natriuretic peptide B susceptibility ISO associated with Renal Insufficiency, chronic;protein:increased expression:blood:
associated with Hypertension,Renal; DNA:SNP:promoter: -381 T>C,rs198389 (human)		 RGD PMID:22863432 PMID:19413180 RGD:7247628, RGD:7248594 NCBI chr 5:158,416,813...158,418,175
Ensembl chr 5:158,416,866...158,418,168 		JBrowse link
G Npy neuropeptide Y severity ISO RGD PMID:21468772 RGD:10448273 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO RGD PMID:21468772 RGD:10448273 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO RGD PMID:21468772 RGD:10448273 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO RGD PMID:21468772 RGD:10448273 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382 		JBrowse link
G Nr1h2 nuclear receptor subfamily 1, group H, member 2 treatment ISO RGD PMID:29593532 PMID:33011372 RGD:401827839, RGD:401842381 NCBI chr 1:95,041,967...95,047,358
Ensembl chr 1:95,041,967...95,047,377 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 treatment ISO mRNA:increased expression:carotid artery segment (human) RGD PMID:29593532 PMID:33011372 PMID:15528463 RGD:401827839, RGD:401842381, RGD:401827901 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Nr1h4 nuclear receptor subfamily 1, group H, member 4 ISO CTD Direct Evidence: therapeutic CTD PMID:30996006 NCBI chr 7:23,846,122...23,942,085
Ensembl chr 7:23,846,122...23,942,047 		JBrowse link
G Parp1 poly (ADP-ribose) polymerase 1 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:18093987 PMID:19124646 PMID:18093987 RGD:5683916 NCBI chr13:92,307,593...92,339,406
Ensembl chr13:92,307,586...92,339,404 		JBrowse link
G Pdgfd platelet derived growth factor D ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 8:3,488,448...3,722,395
Ensembl chr 8:3,488,423...3,722,395 		JBrowse link
G Pdgfrb platelet derived growth factor receptor beta treatment ISO RGD PMID:11413086 RGD:10449506 NCBI chr18:54,499,962...54,538,840
Ensembl chr18:54,499,964...54,538,843 		JBrowse link
G Pecam1 platelet and endothelial cell adhesion molecule 1 severity
resistance		 ISO protein:increased expression:carotid artery (human) RGD PMID:22053073 PMID:21960570 PMID:17659202 RGD:6771176, RGD:6771359, RGD:6771223 NCBI chr10:91,590,521...91,652,279
Ensembl chr10:91,590,521...91,652,116 		JBrowse link
G Pf4 platelet factor 4 ameliorates ISO RGD PMID:19122657 RGD:329901820 NCBI chr14:17,298,304...17,299,220
Ensembl chr14:17,298,308...17,299,365 		JBrowse link
G Pgf placental growth factor ISO RGD PMID:19952000 RGD:6483589 NCBI chr 6:104,816,102...104,826,685
Ensembl chr 6:104,816,104...104,826,685 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 exacerbates ISO mRNA:increased expression:carotid artery (human) RGD PMID:36091033 RGD:401900131 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831 		JBrowse link
G Pik3cg phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma severity ISO RGD PMID:17483449 RGD:1642394 NCBI chr 6:48,766,778...48,802,098
Ensembl chr 6:48,766,864...48,802,043 		JBrowse link
G Pla2g2a phospholipase A2 group IIA ISO CTD Direct Evidence: marker/mechanism CTD PMID:19237014 NCBI chr 5:151,076,442...151,079,019
Ensembl chr 5:151,076,442...151,079,014 		JBrowse link
G Pla2g7 phospholipase A2 group VII ISO associated with Diabetes Mellitus, type 2;DNA:missense mutation: :994G>T(human) RGD PMID:21970837 PMID:12590019 RGD:6482784, RGD:7248796 NCBI chr 9:17,362,214...17,404,476
Ensembl chr 9:17,362,225...17,404,476 		JBrowse link
G Plat plasminogen activator, tissue type ISO CTD Direct Evidence: therapeutic CTD PMID:12677255 NCBI chr16:69,240,582...69,265,177
Ensembl chr16:69,240,585...69,268,223 		JBrowse link
G Plau plasminogen activator, urokinase ISO associated with Kidney Failure, Chronic; protein:increased expression:plasma (human) RGD PMID:17706748 PMID:15096455 RGD:7241201, RGD:7241203 NCBI chr15:3,456,230...3,462,732
Ensembl chr15:3,456,232...3,462,775 		JBrowse link
G Pltp phospholipid transfer protein ISO protein:increased expression:coronary artery (human) RGD PMID:12835223 RGD:1581039 NCBI chr 3:153,574,825...153,592,647
Ensembl chr 3:153,574,825...153,592,647 		JBrowse link
G Polr1c RNA polymerase I and III subunit C ISO ClinVar Annotator: match by term: Atherosclerosis, susceptibility to ClinVar PMID:15732116 PMID:15937083 PMID:18413368 NCBI chr 9:14,735,740...14,739,852
Ensembl chr 9:14,735,714...14,739,852 		JBrowse link
G Pon1 paraoxonase 1 susceptibility
treatment		 ISO mRNA:altered expression::human transgene expression in ApoE-KO mice was protective
CTD Direct Evidence: marker/mechanism|therapeutic
associated with Beta-Thalassemia;protein:decreased activity:serum (human)		 CTD
RGD		 PMID:16216721 PMID:16229851 PMID:16331452 PMID:19371607 PMID:21629682 More... RGD:5509927, RGD:11552582, RGD:8547574, RGD:8547562 NCBI chr 4:33,294,737...33,325,759
Ensembl chr 4:33,294,722...33,321,360 		JBrowse link
G Pon3 paraoxonase 3 ISO mRNA:altered expression::human transgene expression in ApoE-KO mice was protective RGD PMID:20182519 RGD:5509927 NCBI chr 4:33,356,983...33,383,681
Ensembl chr 4:33,349,168...33,383,855 		JBrowse link
G Pparg peroxisome proliferator-activated receptor gamma ISO protein:increased expression:aortic sinus, endothelium (mouse)
CTD Direct Evidence: therapeutic		 CTD
RGD		 PMID:18269830 PMID:15779851 RGD:8552894 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
G Ptges3 prostaglandin E synthase 3 ISO protein:decreased expression:mammary arteries (human) RGD PMID:14736553 RGD:5688075 NCBI chr 7:490,698...507,759
Ensembl chr 7:490,656...508,084 		JBrowse link
G Ptgis prostaglandin I2 synthase ISO mRNA:decreased expression:artery (human) RGD PMID:22112851 RGD:401959395 NCBI chr 3:155,928,564...155,964,228
Ensembl chr 3:155,916,412...155,965,451 		JBrowse link
G Ptgs2 prostaglandin-endoperoxide synthase 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:20720404 NCBI chr13:62,163,936...62,172,193
Ensembl chr13:62,163,932...62,172,188 		JBrowse link
G Rbp4 retinol binding protein 4 exacerbates
disease_progression		 ISO
IEP		 APOE knockout
associated with type 2 diabetes mellitus; mRNA,protein:increased expression:adipose tissue, blood serum (rat)		 RGD PMID:28122883 PMID:33889291 RGD:329845881, RGD:329849122 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Scd stearoyl-CoA desaturase treatment ISO RGD PMID:29593532 PMID:33011372 PMID:23650230 RGD:401827839, RGD:401842381, RGD:401842363 NCBI chr 1:243,269,745...243,282,878
Ensembl chr 1:243,269,747...243,282,562 		JBrowse link
G Scd2 stearoyl-Coenzyme A desaturase 2 treatment ISO RGD PMID:29593532 RGD:401827839 NCBI chr 1:243,169,171...243,182,231
Ensembl chr 1:243,169,236...243,182,232 		JBrowse link
G Sell selectin L ISO RGD PMID:21760899 RGD:5685675 NCBI chr13:76,416,969...76,436,444
Ensembl chr13:76,416,915...76,436,456 		JBrowse link
G Selp selectin P ISO
IEP		 protein:increased expression:aorta RGD PMID:19834105 PMID:22340239 RGD:6478699, RGD:6480102 NCBI chr13:76,476,229...76,511,846
Ensembl chr13:76,476,295...76,511,845 		JBrowse link
G Sergef secretion regulating guanine nucleotide exchange factor ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 1:96,949,660...97,152,529
Ensembl chr 1:96,949,661...97,152,496 		JBrowse link
G Serpine1 serpin family E member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12677255 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
G Sirt1 sirtuin 1 IEP
ISO		 associated with Diabetes Mellitus, Type 2;mRNA:decreased expression:abdominal aorta
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20068143 PMID:21810449 RGD:9585743 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ameliorates ISO myeloid knockout RGD PMID:31495784 RGD:126925203 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
G Socs3 suppressor of cytokine signaling 3 ISO CTD Direct Evidence: marker/mechanism CTD PMID:19330073 NCBI chr10:103,193,909...103,197,322
Ensembl chr10:103,193,537...103,197,787 		JBrowse link
G Sod1 superoxide dismutase 1 severity ISO mRNA:decreased expression:thoracic aorta (mouse)
CTD Direct Evidence: marker/mechanism		 CTD
RGD		 PMID:20720404 PMID:20347443 RGD:8655856 NCBI chr11:29,456,673...29,462,249
Ensembl chr11:29,456,558...29,462,249 		JBrowse link
G Sod2 superoxide dismutase 2 ISO CTD Direct Evidence: marker/mechanism|therapeutic CTD PMID:12677255 PMID:20720404 NCBI chr 1:47,638,318...47,645,163
Ensembl chr 1:47,636,528...47,645,189 		JBrowse link
G Srebf1 sterol regulatory element binding transcription factor 1 treatment ISO RGD PMID:29593532 PMID:31601342 PMID:33011372 PMID:23650230 RGD:401827839, RGD:401850587, RGD:401842381, RGD:401842363 NCBI chr10:45,007,637...45,029,650
Ensembl chr10:45,007,637...45,029,650 		JBrowse link
G Srebf2 sterol regulatory element binding transcription factor 2 treatment ISO RGD PMID:23650230 RGD:401842363 NCBI chr 7:113,663,202...113,720,850
Ensembl chr 7:113,663,202...113,720,848 		JBrowse link
G Stat3 signal transducer and activator of transcription 3 ISO
IEP		 CTD Direct Evidence: marker/mechanism
associated with type 2 diabetes mellitus; mRNA, protein:increased expression, increased phosphorylation:aorta, blood serum (rat)		 CTD
RGD		 PMID:19330073 PMID:33889291 RGD:329849122 NCBI chr10:85,811,206...85,863,057
Ensembl chr10:85,811,218...85,863,057 		JBrowse link
G Stau1 staufen double-stranded RNA binding protein 1 ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 3:155,680,000...155,725,969
Ensembl chr 3:155,680,000...155,725,909 		JBrowse link
G Timp1 TIMP metallopeptidase inhibitor 1 ameliorates ISO RGD PMID:31757932 RGD:242905202 NCBI chr  X:1,212,969...1,217,714
Ensembl chr  X:1,212,972...1,217,664 		JBrowse link
G Tlr2 toll-like receptor 2 ISO RGD PMID:17466307 RGD:8552973 NCBI chr 2:169,200,620...169,206,819
Ensembl chr 2:169,197,419...169,206,630 		JBrowse link
G Tlr4 toll-like receptor 4 ISO CTD Direct Evidence: marker/mechanism CTD PMID:12124407 NCBI chr 5:80,145,867...80,159,501
Ensembl chr 5:80,145,826...80,159,628 		JBrowse link
G Tnf tumor necrosis factor treatment
ameliorates		 ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:20720404 PMID:15823270 PMID:29593532 PMID:35854140 RGD:7401235, RGD:401827839, RGD:242905195 NCBI chr20:3,622,011...3,624,629
Ensembl chr20:3,622,011...3,624,629 		JBrowse link
G Tp53 tumor protein p53 ameliorates ISO RGD PMID:31757932 RGD:242905202 NCBI chr10:54,300,070...54,311,525
Ensembl chr10:54,300,048...54,311,524 		JBrowse link
G Trim28 tripartite motif-containing 28 ISO CTD Direct Evidence: marker/mechanism CTD PMID:31351049 NCBI chr 1:73,652,441...73,659,388
Ensembl chr 1:73,652,709...73,659,380 		JBrowse link
G Trpv1 transient receptor potential cation channel, subfamily V, member 1 ISO CTD Direct Evidence: marker/mechanism CTD PMID:21908651 NCBI chr10:57,851,428...57,876,513
Ensembl chr10:57,851,428...57,876,513 		JBrowse link
G Ttc39b tetratricopeptide repeat domain 39B treatment ISO RGD PMID:29593532 RGD:401827839 NCBI chr 5:97,603,329...97,708,103
Ensembl chr 5:97,609,392...97,736,270 		JBrowse link
G Ttpa alpha tocopherol transfer protein ISO CTD Direct Evidence: marker/mechanism CTD PMID:11095717 NCBI chr 5:33,497,537...33,518,936
Ensembl chr 5:33,497,137...33,518,073 		JBrowse link
G Ubr1 ubiquitin protein ligase E3 component n-recognin 1 ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 3:107,813,721...107,921,701
Ensembl chr 3:107,811,392...107,922,204 		JBrowse link
G Ucn2 urocortin 2 ISO protein:increased expression:coronary artery, endothelium (human) RGD PMID:16026900 RGD:5508308 NCBI chr 8:109,637,624...109,639,173
Ensembl chr 8:109,638,285...109,639,172 		JBrowse link
G Vcam1 vascular cell adhesion molecule 1 ameliorates ISO CTD Direct Evidence: marker/mechanism CTD
RGD		 PMID:12677255 PMID:35854140 RGD:242905195 NCBI chr 2:204,038,120...204,057,852
Ensembl chr 2:204,038,114...204,057,958 		JBrowse link
G Vdr vitamin D receptor ISO RGD PMID:25801026 RGD:14402022 NCBI chr 7:128,987,981...129,037,677
Ensembl chr 7:128,987,981...129,037,677 		JBrowse link
G Vegfa vascular endothelial growth factor A ameliorates ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Atherosclerosis, susceptibility to		 CTD
ClinVar
RGD		 PMID:15732116 PMID:15937083 PMID:18413368 PMID:31757932 RGD:242905202 NCBI chr 9:14,955,300...14,970,641
Ensembl chr 9:14,955,300...14,970,641 		JBrowse link
G Vegfc vascular endothelial growth factor C ISO associated with hypercholesterolemia;protein:increased expression:serum: RGD PMID:22206010 RGD:7483588 NCBI chr16:37,712,251...37,827,845
Ensembl chr16:37,712,262...37,827,848 		JBrowse link
G Vim vimentin ISO associated with arthritis,rheumatoid RGD PMID:21362765 RGD:6480618 NCBI chr17:76,668,701...76,677,186
Ensembl chr17:76,668,647...76,677,187 		JBrowse link
G Wiz WIZ zinc finger ISO associated with methylation, coronary artery disease:mRNA:altered expression:artery wall (human) RGD PMID:33381146 RGD:155882464 NCBI chr 7:11,366,837...11,395,279
Ensembl chr 7:11,367,035...11,395,490 		JBrowse link
G Wnt1 Wnt family member 1 ameliorates ISO RGD PMID:35854140 RGD:242905195 NCBI chr 7:129,938,604...129,942,651
Ensembl chr 7:129,938,604...129,942,651 		JBrowse link
aortic atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Abca1 ATP binding cassette subfamily A member 1 ISO mRNA,protein:decreased expression:aorta RGD PMID:33035679 RGD:401793744 NCBI chr 5:67,678,267...67,801,162
Ensembl chr 5:67,681,297...67,801,170 		JBrowse link
G Apoe apolipoprotein E IMP RGD PMID:29459263 RGD:13703129 NCBI chr 1:79,353,924...79,357,852
Ensembl chr 1:79,353,916...79,357,932 		JBrowse link
G Capn1 calpain 1 IEP protein:increased activity:aorta RGD PMID:23006733 RGD:13792498 NCBI chr 1:203,275,912...203,300,848
Ensembl chr 1:203,277,344...203,300,177 		JBrowse link
G Edn1 endothelin 1 exacerbates ISO associated with type 1 diabetes mellitus; RGD PMID:32533834 RGD:329955566 NCBI chr17:22,454,924...22,460,812
Ensembl chr17:22,454,420...22,460,885 		JBrowse link
G Il33 interleukin 33 ISO protein:increased expression:artery: RGD PMID:31043075 RGD:267986209 NCBI chr 1:227,701,964...227,736,374
Ensembl chr 1:227,721,435...227,736,373 		JBrowse link
G Ldlr low density lipoprotein receptor IMP RGD PMID:29459263 RGD:13703129 NCBI chr 8:20,270,020...20,292,981
Ensembl chr 8:20,270,041...20,294,580 		JBrowse link
G Ldlrem1Dlli low density lipoprotein receptor; CRISPR/Cas9 induced mutant 1, Dlli IMP RGD PMID:29459263 RGD:13703129
G Mir223 microRNA 223 ISO RNA:increased expression:serum,aorta RGD PMID:26065992 RGD:25824846 NCBI chr  X:61,141,887...61,141,996
Ensembl chr  X:61,141,887...61,141,996 		JBrowse link
G Myocd myocardin exacerbates ISO protein:decreased expression:aorta RGD PMID:33035679 PMID:33035679 RGD:401793744, RGD:401793744 NCBI chr10:49,833,219...49,928,806
Ensembl chr10:49,836,641...49,927,627 		JBrowse link
G Nox1 NADPH oxidase 1 ameliorates ISO associated with type 1 diabetes mellitus; RGD PMID:32533834 RGD:329955566 NCBI chr  X:97,279,058...97,332,291
Ensembl chr  X:97,279,056...97,302,236 		JBrowse link
G Ppbp pro-platelet basic protein ISO protein:increased expression:thrombus,artery RGD PMID:17045893 RGD:401794448 NCBI chr14:17,302,326...17,303,130
Ensembl chr14:17,302,326...17,303,130 		JBrowse link
G Soat1 sterol O-acyltransferase 1 ameliorates ISO associated with Hypercholesterolemia RGD PMID:30282838 RGD:126925208 NCBI chr13:68,552,274...68,597,529
Ensembl chr13:68,552,317...68,597,494 		JBrowse link
Carotid Atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Agxt2 alanine-glyoxylate aminotransferase 2 ISO DNA:missense mutations:cds:multiple (human) RGD PMID:25620171 RGD:329961318 NCBI chr 2:59,336,252...59,377,664
Ensembl chr 2:59,336,283...59,377,926 		JBrowse link
G Ccn1 cellular communication network factor 1 ISO protein:increased expression:carotid artery segment (human) RGD PMID:16774841 RGD:329845567 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Fgf21 fibroblast growth factor 21 ISO protein:increased expression:serum: RGD PMID:23887638 RGD:10401924 NCBI chr 1:96,083,360...96,084,911
Ensembl chr 1:96,083,441...96,090,454 		JBrowse link
G Fto FTO, alpha-ketoglutarate dependent dioxygenase ISO DNA:SNP:intron:rs9937354 (human) RGD PMID:36894991 RGD:329901850 NCBI chr19:15,284,898...15,692,142
Ensembl chr19:15,349,696...15,692,083 		JBrowse link
G Glul glutamate-ammonia ligase ISO RGD PMID:35667160 RGD:401793760 NCBI chr13:65,969,053...66,035,121
Ensembl chr13:66,025,630...66,035,108 		JBrowse link
G Gpx3 glutathione peroxidase 3 ISO associated with type 2 diabetes mellitus RGD PMID:32862561 RGD:401827123 NCBI chr10:39,028,624...39,036,695
Ensembl chr10:39,028,570...39,037,035 		JBrowse link
G Hrg histidine-rich glycoprotein disease_progression ISO protein:increased expression:carotid artery segment (human) RGD PMID:16774841 RGD:329845567 NCBI chr11:78,054,488...78,069,402
Ensembl chr11:78,054,498...78,069,389 		JBrowse link
G Ifnb1 interferon beta 1 ameliorates ISO RGD PMID:17466308 RGD:401854230 NCBI chr 5:103,020,758...103,021,595
Ensembl chr 5:103,020,969...103,021,523 		JBrowse link
G Itln1 intelectin 1 severity ISO protein:decreased expression:blood serum (human) RGD PMID:24956535 RGD:329845846 NCBI chr13:83,932,234...83,958,243
Ensembl chr13:83,948,124...83,958,227 		JBrowse link
G Kmt2d lysine methyltransferase 2D severity ISO RGD PMID:26764138 RGD:155582215 NCBI chr 7:129,980,744...130,022,088
Ensembl chr 7:129,962,887...130,020,325 		JBrowse link
G Mmp9 matrix metallopeptidase 9 disease_progression ISO protein:increased expression:carotid artery segment (human) RGD PMID:16774841 RGD:329845567 NCBI chr 3:153,684,158...153,692,118
Ensembl chr 3:153,683,858...153,692,120 		JBrowse link
G Nr1h3 nuclear receptor subfamily 1, group H, member 3 exacerbates ISO DNA:silent mutation:exon 4:c.297C>T (rs2279238) (human) RGD PMID:35907563 RGD:401842367 NCBI chr 3:77,158,808...77,168,907
Ensembl chr 3:77,158,808...77,168,722 		JBrowse link
G Pcsk5 proprotein convertase subtilisin/kexin type 5 ISO protein:increased expression:myofibroblast: RGD PMID:14970114 RGD:11556214 NCBI chr 1:214,837,847...215,267,626
Ensembl chr 1:214,837,927...215,267,600 		JBrowse link
G Phactr1 phosphatase and actin regulator 1 severity ISO DNA:SNPs, haplotype:intron 3: (rs9349379, rs2026458, rs2876300) (human) RGD PMID:31200082 RGD:401900133 NCBI chr17:21,560,364...22,040,166
Ensembl chr17:21,562,721...22,039,831 		JBrowse link
G Rbp4 retinol binding protein 4 severity ISO protein:increased expression:blood serum (human) RGD PMID:24956535 RGD:329845846 NCBI chr 1:235,893,917...235,901,315
Ensembl chr 1:235,893,917...235,901,399 		JBrowse link
G Sirt1 sirtuin 1 ISO mRNA, protein:decreased expression:carotid artery segment RGD PMID:23224247 RGD:9495924 NCBI chr20:25,307,225...25,329,273
Ensembl chr20:25,306,917...25,329,260 		JBrowse link
Carotid Intimal Medial Thickness 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Pparg peroxisome proliferator-activated receptor gamma ISO CTD Direct Evidence: marker/mechanism
ClinVar Annotator: match by term: Carotid intimal medial thickness 1		 OMIM
CTD
ClinVar		 PMID:25741868 PMID:27749844 NCBI chr 4:148,423,102...148,548,471
Ensembl chr 4:148,423,194...148,548,468 		JBrowse link
cerebral atherosclerosis term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Kalrn kalirin, RhoGEF kinase susceptibility ISO DNA:SNP:intron: (rs6438833) (human) RGD PMID:30232674 RGD:329956416 NCBI chr11:66,198,155...66,803,166
Ensembl chr11:66,198,173...66,797,610 		JBrowse link
Peripheral Arterial Occlusive Disease 1 term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Serpina3n serpin family A member 3N ISO ClinVar Annotator: match by term: Peripheral arterial occlusive disease 1 ClinVar PMID:1618300 PMID:9040504 PMID:11289720 PMID:25741868 NCBI chr 6:123,323,623...123,331,181
Ensembl chr 6:123,323,629...123,332,433 		JBrowse link
peripheral artery disease term browser
Symbol Object Name Qualifiers Evidence Notes Source PubMed Reference(s) RGD Reference(s) Position
G Adipoq adiponectin, C1Q and collagen domain containing ISO protein:decreased expression:plasma RGD PMID:16321391 RGD:5686716 NCBI chr11:77,721,912...77,735,644
Ensembl chr11:77,721,912...77,735,564 		JBrowse link
G B2m beta-2 microglobulin severity ISO RGD PMID:21314441 RGD:6482704 NCBI chr 3:109,095,740...109,101,764
Ensembl chr 3:109,095,729...109,101,766 		JBrowse link
G Bmp2 bone morphogenetic protein 2 ISO CTD Direct Evidence: marker/mechanism CTD PMID:27082954 NCBI chr 3:120,812,660...120,822,579
Ensembl chr 3:120,812,882...120,821,397 		JBrowse link
G Bmp8a bone morphogenetic protein 8a ISO CTD Direct Evidence: marker/mechanism CTD PMID:27082954 NCBI chr 5:135,589,839...135,617,785
Ensembl chr 5:135,591,716...135,617,785 		JBrowse link
G Ccn1 cellular communication network factor 1 severity ISO associated with type 2 diabetes mellitus; protein:increased expression:blood serum (human) RGD PMID:33222686 RGD:329845552 NCBI chr 2:234,562,410...234,565,370
Ensembl chr 2:234,562,408...234,565,484 		JBrowse link
G Dab2ip DAB2 interacting protein ISO DNA:SNP:CDS:intron 1 (rs7025486) (human) RGD PMID:20622881 RGD:401901599 NCBI chr 3:18,915,290...19,086,282
Ensembl chr 3:18,915,290...19,086,280 		JBrowse link
G Gch1 GTP cyclohydrolase 1 treatment ISO associated with Experimental Diabetes Mellitus RGD PMID:31623833 RGD:329961326 NCBI chr15:20,404,267...20,437,727
Ensembl chr15:20,402,527...20,437,698 		JBrowse link
G Mthfr methylenetetrahydrofolate reductase susceptibility ISO associated with Diabetes Mellitus, Type 2;DNA:transition:cds:g.677C>T (human) RGD PMID:16274479 RGD:6893659 NCBI chr 5:158,465,248...158,484,999
Ensembl chr 5:158,465,296...158,483,797 		JBrowse link
G Npy neuropeptide Y ISO RGD PMID:21468772 RGD:10448273 NCBI chr 4:78,881,294...78,888,495
Ensembl chr 4:78,881,264...78,888,495 		JBrowse link
G Npy1r neuropeptide Y receptor Y1 ISO RGD PMID:21468772 RGD:10448273 NCBI chr16:23,037,788...23,047,330
Ensembl chr16:23,037,789...23,046,759 		JBrowse link
G Npy2r neuropeptide Y receptor Y2 ISO RGD PMID:21468772 RGD:10448273 NCBI chr 2:167,901,999...167,912,165
Ensembl chr 2:167,903,879...167,905,024 		JBrowse link
G Npy5r neuropeptide Y receptor Y5 ISO RGD PMID:21468772 RGD:10448273 NCBI chr16:23,055,427...23,063,384
Ensembl chr16:23,055,427...23,063,382 		JBrowse link
G P2ry12 purinergic receptor P2Y12 ISO RGD PMID:14662702 RGD:1580188 NCBI chr 2:143,481,468...143,523,340
Ensembl chr 2:143,481,430...143,523,361 		JBrowse link
G Serpine1 serpin family E member 1 ISO associated with Diabetes Mellitus, Type 1;protein:increased expression:plasma (human) RGD PMID:9201602 RGD:8547710 NCBI chr12:19,601,272...19,611,657
Ensembl chr12:19,601,272...19,611,657 		JBrowse link
Term paths to the root
Path 1
Term Annotations click to browse term
  disease 19057
    disease of anatomical entity 18393
      cardiovascular system disease 5515
        vascular disease 4018
          Arterial Occlusive Diseases 847
            arteriosclerosis 819
              arteriosclerotic cardiovascular disease 236
                atherosclerosis 236
                  Carotid Atherosclerosis 16
                  Carotid Intimal Medial Thickness 1 1
                  Premature Atherosclerosis with Deafness, Nephropathy, Diabetes Mellitus, Photomyoclonus, and Degenerative Neurologic Disease 0
                  aortic atherosclerosis 15
                  cerebral atherosclerosis 1
                  generalized atherosclerosis 0
                  peripheral artery disease + 15
                  renal artery atheroma 0
paths to the root