RGD Reference Report - Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice. - Rat Genome Database

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Interleukin 27 inhibits atherosclerosis via immunoregulation of macrophages in mice.

Authors: Hirase, Tetsuaki  Hara, Hiromitsu  Miyazaki, Yoshiyuki  Ide, Noriko  Nishimoto-Hazuku, Ai  Fujimoto, Hirokazu  Saris, Christiaan J M  Yoshida, Hiroki  Node, Koichi 
Citation: Hirase T, etal., Am J Physiol Heart Circ Physiol. 2013 Aug 1;305(3):H420-9. doi: 10.1152/ajpheart.00198.2013. Epub 2013 May 31.
RGD ID: 39456136
Pubmed: PMID:23729211   (View Abstract at PubMed)
DOI: DOI:10.1152/ajpheart.00198.2013   (Journal Full-text)

Chronic inflammation in arterial wall that is driven by immune cells and cytokines plays pivotal roles in the development of atherosclerosis. Interleukin 27 (IL-27) is a member of the IL-12 family of cytokines that consists of IL-27p28 and Epstein-Barr virus induced gene 3 (EBI3) and has anti-inflammatory properties that regulate T cell polarization and cytokine production. IL-27-deficient (Ldlr-/-Ebi3-/-) and IL-27 receptor-deficient (Ldlr-/-WSX-1-/-) Ldlr-/- mice were generated and fed with a high-cholesterol diet to induce atherosclerosis. Roles of bone marrow-derived cells in vivo and macrophages in vitro were studied using bone marrow reconstitution by transplantation and cultured peritoneal macrophages, respectively. We demonstrate that mice lacking IL-27 or IL-27 receptor are more susceptible to atherosclerosis compared with wild type due to enhanced accumulation and activation of macrophages in arterial walls. The number of circulating proinflammatory Ly6C(hi) monocytes showed no significant difference between wild-type mice and mice lacking IL-27 or IL-27 receptor. Administration of IL-27 suppressed the development of atherosclerosis in vivo and macrophage activation in vitro that was indicated by increased uptake of modified low-density lipoprotein and augmented production of proinflammatory cytokines. These findings define a novel inhibitory role for IL-27 in atherosclerosis that regulates macrophage activation in mice.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
IL27Humanatherosclerosis amelioratesISOIl27 (Mus musculus) RGD 
Il27Ratatherosclerosis amelioratesISOIl27 (Mus musculus) RGD 
Il27Mouseatherosclerosis amelioratesIMP  RGD 

Objects Annotated

Genes (Rattus norvegicus)
Il27  (interleukin 27)

Genes (Mus musculus)
Il27  (interleukin 27)

Genes (Homo sapiens)
IL27  (interleukin 27)


Additional Information