Lsm4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated) - Rat Genome Database

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Gene: Lsm4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated) Rattus norvegicus
Analyze
Symbol: Lsm4
Name: LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
RGD ID: 1306808
Description: Predicted to enable PH domain binding activity and U6 snRNA binding activity. Predicted to be involved in P-body assembly and spliceosomal snRNP assembly. Predicted to be located in cytosol; membrane; and nucleus. Predicted to be part of Lsm2-8 complex; U2-type precatalytic spliceosome; and spliceosomal snRNP complex. Predicted to be active in P-body. Orthologous to human LSM4 (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated); PARTICIPATES IN spliceosome pathway; RNA degradation pathway; INTERACTS WITH 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine; 2,4,6-trinitrotoluene.
Type: protein-coding
RefSeq Status: PROVISIONAL
Previously known as: LOC290647; LSM4 homolog, U6 small nuclear RNA associated; LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae); LSM4 U6 small nuclear RNA and mRNA degradation associated; U6 snRNA-associated Sm-like protein LSm4
RGD Orthologs
Human
Mouse
Chinchilla
Bonobo
Dog
Squirrel
Pig
Green Monkey
Naked Mole-Rat
Alliance Orthologs
More Info more info ...
Latest Assembly: GRCr8 - GRCr8 Assembly
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,789,466 - 18,795,164 (-)NCBIGRCr8
mRatBN7.21618,755,481 - 18,761,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,755,484 - 18,760,926 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,797,134 - 18,802,546 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,930,058 - 19,935,475 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,850,088 - 18,855,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,506,399 - 20,511,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,506,399 - 20,511,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,363,442 - 20,368,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,261,065 - 19,266,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,261,067 - 19,266,367 (-)NCBI
Celera1618,947,390 - 18,952,806 (-)NCBICelera
Cytogenetic Map16p14NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model



  
Object Symbol
Species
Term
Qualifier
Evidence
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Reference
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Original Reference(s)
Lsm4Ratatherosclerosis  ISOLSM4 (Homo sapiens)155882464associated with methylation and coronary artery disease:mRNA:altered expression:artery wall (human)RGD 
Object Symbol
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Reference
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Original Reference(s)
Lsm4RatMegalencephaly-Polymicrogyria-Polydactyly-Hydrocephalus Syndrome 1  ISOLSM4 (Homo sapiens)8554872ClinVar Annotator: match by term: Megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 1ClinVarPMID:28492532

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Object Symbol
Species
Term
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Reference
Notes
Source
Original Reference(s)
Lsm4Rat1,2-dimethylhydrazine multiple interactionsISOLsm4 (Mus musculus)6480464[1 and 2-Dimethylhydrazine co-treated with Folic Acid] results in decreased expression of LSM4 mRNACTDPMID:22206623
Lsm4Rat17alpha-ethynylestradiol increases expressionISOLsm4 (Mus musculus)6480464Ethinyl Estradiol results in increased expression of LSM4 mRNACTDPMID:17942748
Lsm4Rat17alpha-ethynylestradiol multiple interactionsISOLsm4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LSM4 mRNACTDPMID:17942748
Lsm4Rat17beta-estradiol increases expressionEXP 6480464Estradiol results in increased expression of LSM4 mRNACTDPMID:32145629
Lsm4Rat17beta-estradiol increases expressionISOLsm4 (Mus musculus)6480464Estradiol results in increased expression of LSM4 mRNACTDPMID:39298647
Lsm4Rat2,2',4,4'-Tetrabromodiphenyl ether affects expressionISOLsm4 (Mus musculus)64804642 more ...CTDPMID:30294300
Lsm4Rat2,3,7,8-tetrachlorodibenzodioxine multiple interactionsISOLsm4 (Mus musculus)6480464[Tetrachlorodibenzodioxin co-treated with Ethinyl Estradiol] results in increased expression of LSM4 mRNACTDPMID:17942748
Lsm4Rat2,3,7,8-tetrachlorodibenzodioxine decreases expressionEXP 6480464Tetrachlorodibenzodioxin results in decreased expression of LSM4 mRNACTDPMID:34747641
Lsm4Rat2,3,7,8-tetrachlorodibenzodioxine affects expressionISOLsm4 (Mus musculus)6480464Tetrachlorodibenzodioxin affects the expression of LSM4 mRNACTDPMID:21570461
Lsm4Rat2,4,6-trinitrotoluene affects expressionEXP 6480464Trinitrotoluene affects the expression of LSM4 mRNACTDPMID:21346803
Lsm4Rat2,4-dinitrotoluene affects expressionEXP 64804642 and 4-dinitrotoluene affects the expression of LSM4 mRNACTDPMID:21346803
Lsm4Rat2,6-dinitrotoluene affects expressionEXP 64804642 and 6-dinitrotoluene affects the expression of LSM4 mRNACTDPMID:21346803
Lsm4Rat2-palmitoylglycerol increases expressionISOLSM4 (Homo sapiens)64804642-palmitoylglycerol results in increased expression of LSM4 mRNACTDPMID:37199045
Lsm4Rat3-methylcholanthrene increases expressionISOLsm4 (Mus musculus)6480464Methylcholanthrene results in increased expression of LSM4 mRNACTDPMID:20713471
Lsm4Rat4,4'-sulfonyldiphenol affects expressionISOLsm4 (Mus musculus)6480464bisphenol S affects the expression of LSM4 mRNACTDPMID:39298647
Lsm4Rat6-propyl-2-thiouracil increases expressionEXP 6480464Propylthiouracil results in increased expression of LSM4 mRNACTDPMID:30047161
Lsm4Rat7,12-dimethyltetraphene increases expressionISOLsm4 (Mus musculus)64804649 more ...CTDPMID:38307155
Lsm4Ratacrylamide increases expressionEXP 6480464Acrylamide results in increased expression of LSM4 mRNACTDPMID:28959563
Lsm4Rataflatoxin B1 decreases methylationISOLSM4 (Homo sapiens)6480464Aflatoxin B1 results in decreased methylation of LSM4 intronCTDPMID:30157460
Lsm4Ratamitrole increases expressionEXP 6480464Amitrole results in increased expression of LSM4 mRNACTDPMID:30047161

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Biological Process
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Original Reference(s)
Lsm4Ratbiological_process  ND 159840704/2015: no relevant rat dataRGD 
Lsm4RatmRNA processing involved_inIEAUniProtKB-KW:KW-05071600115GO_REF:0000043UniProtGO_REF:0000043
Lsm4RatmRNA splicing, via spliceosome involved_inISOLSM4 (Homo sapiens)1624291 PMID:28781166RGDPMID:28781166
Lsm4RatmRNA splicing, via spliceosome involved_inIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4RatmRNA splicing, via spliceosome involved_inIEAInterPro:IPR0341011600115GO_REF:0000002InterProGO_REF:0000002
Lsm4Ratnuclear-transcribed mRNA catabolic process involved_inIEAUniRule:UR0009317801600115GO_REF:0000104UniProtGO_REF:0000104
Lsm4Ratnuclear-transcribed mRNA catabolic process involved_inIEAInterPro:IPR0341011600115GO_REF:0000002InterProGO_REF:0000002
Lsm4RatP-body assembly involved_inIBAPANTHER:PTN000596817 and SGD:S0000009141600115GO_REF:0000033GO_CentralGO_REF:0000033
Lsm4RatRNA processing involved_inIEAInterPro:IPR0271411600115GO_REF:0000002InterProGO_REF:0000002
Lsm4RatRNA splicing involved_inIEAUniProtKB-KW:KW-05081600115GO_REF:0000043UniProtGO_REF:0000043
Lsm4Ratspliceosomal snRNP assembly involved_inIBAPANTHER:PTN000596745 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
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Cellular Component
1 to 20 of 23 rows

  
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Original Reference(s)
Lsm4Ratcytosol located_inISOLSM4 (Homo sapiens)1624291 PMID:15905169RGDPMID:15905169
Lsm4Ratcytosol located_inIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4RatLsm2-8 complex part_ofISOLSM4 (Homo sapiens)1624291 PMID:10523320RGDPMID:10523320
Lsm4RatLsm2-8 complex part_ofIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4Ratmembrane located_inIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4Ratmembrane located_inISOLSM4 (Homo sapiens)1624291 PMID:15905169RGDPMID:15905169
Lsm4Ratnucleus located_inIEAUniProtKB-KW:KW-05391600115GO_REF:0000043UniProtGO_REF:0000043
Lsm4Ratnucleus located_inIEAARBA:ARBA000263301600115GO_REF:0000117UniProtGO_REF:0000117
Lsm4Ratnucleus located_inIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4Ratnucleus located_inISOLSM4 (Homo sapiens)1624291 PMID:26912367RGDPMID:26912367
Lsm4Ratnucleus located_inIEAUniProtKB-SubCell:SL-01911600115GO_REF:0000044UniProtGO_REF:0000044
Lsm4RatP-body is_active_inIBAPANTHER:PTN000596817 and SGD:S0000009141600115GO_REF:0000033GO_CentralGO_REF:0000033
Lsm4Ratprotein-containing complex part_ofISOLSM4 (Homo sapiens)1624291 PMID:15905169RGDPMID:15905169
Lsm4Ratprotein-containing complex part_ofIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4Ratribonucleoprotein complex part_ofIEAUniProtKB-KW:KW-06871600115GO_REF:0000043UniProtGO_REF:0000043
Lsm4Ratspliceosomal complex part_ofIEAUniProtKB-KW:KW-07471600115GO_REF:0000043UniProtGO_REF:0000043
Lsm4Ratspliceosomal complex part_ofIEAUniRule:UR0009317801600115GO_REF:0000104UniProtGO_REF:0000104
Lsm4Ratspliceosomal tri-snRNP complex part_ofIBAPANTHER:PTN000596817 more ...1600115GO_REF:0000033GO_CentralGO_REF:0000033
Lsm4RatU2-type precatalytic spliceosome part_ofISOLSM4 (Homo sapiens)1624291 PMID:28781166RGDPMID:28781166
Lsm4RatU2-type precatalytic spliceosome part_ofIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
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Molecular Function

  
Object Symbol
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Original Reference(s)
Lsm4RatPH domain binding enablesISOLSM4 (Homo sapiens)1624291 PMID:15905169RGDPMID:15905169
Lsm4RatPH domain binding enablesIEAUniProtKB:Q9Y4Z0 and ensembl:ENSP000004694681600115GO_REF:0000107EnsemblGO_REF:0000107
Lsm4Ratprotein binding enablesISOLSM4 (Homo sapiens)1624291UniProtKB:O15116 more ...RGDPMID:15231747 more ...
Lsm4RatRNA binding enablesIEAInterPro:IPR0475751600115GO_REF:0000002InterProGO_REF:0000002
Lsm4RatRNA binding enablesIEAUniProtKB-KW:KW-06941600115GO_REF:0000043UniProtGO_REF:0000043
Lsm4RatU6 snRNA binding enablesIBAPANTHER:PTN000596817 and SGD:S0000009141600115GO_REF:0000033GO_CentralGO_REF:0000033

RGD Manual Annotations


  
Object Symbol
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Original Reference(s)
Lsm4Ratspliceosome pathway   ISOLSM4 (Homo sapiens)9686091 RGD 
Lsm4Ratspliceosome pathway   ISOLSM4 (Homo sapiens)9686089 RGD 

Imported Annotations - KEGG (archival)

Object Symbol
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Original Reference(s)
Lsm4RatRNA degradation pathway  IEA 6907045 KEGGrno:03018
Lsm4Ratspliceosome pathway   IEA 6907045 KEGGrno:03040

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#
Reference Title
Reference Citation
1. Proteomic analysis of in vivo-assembled pre-mRNA splicing complexes expands the catalog of participating factors. Chen YI, etal., Nucleic Acids Res. 2007;35(12):3928-44. Epub 2007 May 30.
2. Dendritic LSm1/CBP80-mRNPs mark the early steps of transport commitment and translational control. di Penta A, etal., J Cell Biol. 2009 Feb 9;184(3):423-35. doi: 10.1083/jcb.200807033. Epub 2009 Feb 2.
3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, etal., Brief Bioinform. 2011 Sep;12(5):449-62. doi: 10.1093/bib/bbr042. Epub 2011 Aug 27.
4. Rat ISS GO annotations from GOA human gene data--August 2006 GOA data from the GO Consortium
5. Rat ISS GO annotations from MGI mouse gene data--August 2006 MGD data from the GO Consortium
6. KEGG Annotation Import Pipeline Pipeline to import KEGG annotations from KEGG into RGD
7. GOA pipeline RGD automated data pipeline
8. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
9. Comprehensive gene review and curation RGD comprehensive gene curation
10. The spliceosome: design principles of a dynamic RNP machine. Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
11. Aberrantly Methylated-Differentially Expressed Genes Identify Novel Atherosclerosis Risk Subtypes. Xue Y, etal., Front Genet. 2020 Dec 14;11:569572. doi: 10.3389/fgene.2020.569572. eCollection 2020.
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PMID:10523320   PMID:15905169   PMID:22658674   PMID:22681889   PMID:26912367   PMID:28781166  



Lsm4
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81618,789,466 - 18,795,164 (-)NCBIGRCr8
mRatBN7.21618,755,481 - 18,761,106 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1618,755,484 - 18,760,926 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1618,797,134 - 18,802,546 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01619,930,058 - 19,935,475 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01618,850,088 - 18,855,500 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01620,506,399 - 20,511,818 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1620,506,399 - 20,511,818 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01620,363,442 - 20,368,886 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.41619,261,065 - 19,266,484 (-)NCBIRGSC3.4RGSC_v3.4rn4RGSC3.4
RGSC_v3.11619,261,067 - 19,266,367 (-)NCBI
Celera1618,947,390 - 18,952,806 (-)NCBICelera
Cytogenetic Map16p14NCBI
LSM4
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381918,306,236 - 18,323,076 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl1918,306,236 - 18,323,112 (-)EnsemblGRCh38hg38GRCh38
GRCh371918,417,046 - 18,433,886 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361918,278,717 - 18,294,962 (-)NCBINCBI36Build 36hg18NCBI36
Build 341918,278,717 - 18,294,958NCBI
Celera1918,319,475 - 18,335,755 (-)NCBICelera
Cytogenetic Map19p13.11NCBI
HuRef1917,980,724 - 17,997,682 (-)NCBIHuRef
CHM1_11918,417,296 - 18,434,252 (-)NCBICHM1_1
T2T-CHM13v2.01918,440,354 - 18,457,193 (-)NCBIT2T-CHM13v2.0
Lsm4
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm39871,124,663 - 71,131,402 (+)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl871,125,898 - 71,131,402 (+)EnsemblGRCm39 Ensembl
GRCm38870,673,231 - 70,678,752 (+)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl870,673,248 - 70,678,752 (+)EnsemblGRCm38mm10GRCm38
MGSCv37873,197,130 - 73,202,651 (+)NCBIGRCm37MGSCv37mm9NCBIm37
MGSCv36873,602,381 - 73,607,741 (+)NCBIMGSCv36mm8
Celera873,229,842 - 73,235,362 (+)NCBICelera
Cytogenetic Map8B3.3NCBI
cM Map834.15NCBI
Lsm4
(Chinchilla lanigera - long-tailed chinchilla)
Chinchilla AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChiLan1.0 EnsemblNW_0049555243,157,607 - 3,165,196 (+)EnsemblChiLan1.0
ChiLan1.0NW_0049555243,157,607 - 3,165,196 (+)NCBIChiLan1.0ChiLan1.0
LSM4
(Pan paniscus - bonobo/pygmy chimpanzee)
Bonobo AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
NHGRI_mPanPan1-v22023,167,478 - 23,183,873 (-)NCBINHGRI_mPanPan1-v2
NHGRI_mPanPan11922,175,796 - 22,192,193 (-)NCBINHGRI_mPanPan1
Mhudiblu_PPA_v01917,785,580 - 17,801,866 (-)NCBIMhudiblu_PPA_v0Mhudiblu_PPA_v0panPan3
PanPan1.11918,757,390 - 18,773,812 (-)NCBIpanpan1.1PanPan1.1panPan2
PanPan1.1 Ensembl1918,757,390 - 18,773,812 (-)Ensemblpanpan1.1panPan2
LSM4
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.12044,707,460 - 44,720,490 (+)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl2044,707,460 - 44,720,490 (+)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha2044,621,620 - 44,634,648 (+)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.02045,193,083 - 45,206,148 (+)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl2045,193,083 - 45,206,124 (+)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.12044,430,435 - 44,443,463 (+)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.02044,840,880 - 44,853,912 (+)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.02045,116,311 - 45,129,341 (+)NCBIUU_Cfam_GSD_1.0
Lsm4
(Ictidomys tridecemlineatus - thirteen-lined ground squirrel)
Squirrel AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HiC_Itri_2NW_024405118203,354,208 - 203,367,493 (+)NCBIHiC_Itri_2
SpeTri2.0 EnsemblNW_0049365962,903,358 - 2,916,629 (+)EnsemblSpeTri2.0SpeTri2.0 Ensembl
SpeTri2.0NW_0049365962,903,363 - 2,916,629 (+)NCBISpeTri2.0SpeTri2.0SpeTri2.0
LSM4
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl259,499,564 - 59,513,246 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.1259,499,560 - 59,513,258 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
LSM4
(Chlorocebus sabaeus - green monkey)
Green Monkey AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
ChlSab1.1616,783,566 - 16,800,116 (-)NCBIChlSab1.1ChlSab1.1chlSab2
ChlSab1.1 Ensembl616,782,746 - 16,800,143 (-)EnsemblChlSab1.1ChlSab1.1 EnsemblchlSab2
Vero_WHO_p1.0NW_0236660742,555,195 - 2,572,041 (+)NCBIVero_WHO_p1.0Vero_WHO_p1.0
Lsm4
(Heterocephalus glaber - naked mole-rat)
Naked Mole-Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
HetGla_female_1.0 EnsemblNW_0046249081,595,877 - 1,603,043 (-)EnsemblHetGla_female_1.0HetGla_female_1.0 EnsemblhetGla2
HetGla 1.0NW_0046249081,595,877 - 1,603,075 (-)NCBIHetGla_female_1.0HetGla 1.0hetGla2

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Variants in Lsm4
19 total Variants

Predicted Target Of
Summary Value
Count of predictions:265
Count of miRNA genes:184
Interacting mature miRNAs:197
Transcripts:ENSRNOT00000026567
Prediction methods:Microtar, Miranda, Rnahybrid
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


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The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD ID
Symbol
Name
LOD
P Value
Trait
Sub Trait
Chr
Start
Stop
Species
631561Hcuc2Hepatic copper content QTL 22.8liver copper amount (VT:0003065)liver total copper weight (CMO:0001507)16139533949Rat
1582235Insul8Insulin level QTL 83.30.0063blood insulin amount (VT:0001560)calculated serum insulin level (CMO:0000359)16126727669Rat
2307172Activ4Activity QTL 43.710.00023locomotor behavior trait (VT:0001392)number of entries into a discrete space in an experimental apparatus (CMO:0000960)16133418960Rat
1354584Despr6Despair related QTL 63.10.0067locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16139533930Rat
2302380Slep6Serum leptin concentration QTL 63.36blood leptin amount (VT:0005667)serum leptin level (CMO:0000780)16132139025Rat
737819Hcas4Hepatocarcinoma susceptibility QTL 44.43liver integrity trait (VT:0010547)volume of individual liver tumorous lesion (CMO:0001078)16422760946975965Rat
631517Scl9Serum cholesterol level QTL 93.3blood cholesterol amount (VT:0000180)serum total cholesterol level (CMO:0000363)161572643321034895Rat
9590151Scort8Serum corticosterone level QTL 88.450.001blood corticosterone amount (VT:0005345)plasma corticosterone level (CMO:0001173)16130836262Rat
1354625Despr7Despair related QTL 73.160.016locomotor behavior trait (VT:0001392)amount of time spent in voluntary immobility (CMO:0001043)16144977551Rat
61338Bp23Blood pressure QTL 234.3arterial blood pressure trait (VT:2000000)systolic blood pressure (CMO:0000004)16422760949227609Rat

1 to 10 of 28 rows
RH133230  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,760,978 - 18,761,184 (+)MAPPERmRatBN7.2
Rnor_6.01620,511,896 - 20,512,101NCBIRnor6.0
Rnor_5.01620,368,964 - 20,369,169UniSTSRnor5.0
RGSC_v3.41619,266,562 - 19,266,767UniSTSRGSC3.4
Celera1618,952,884 - 18,953,089UniSTS
RH 3.4 Map16190.5UniSTS
Cytogenetic Map16p14UniSTS
RH141667  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,761,407 - 18,761,596 (+)MAPPERmRatBN7.2
Rnor_6.01620,512,325 - 20,512,513NCBIRnor6.0
Rnor_5.01620,369,393 - 20,369,581UniSTSRnor5.0
RGSC_v3.41619,266,991 - 19,267,179UniSTSRGSC3.4
Celera1618,953,313 - 18,953,501UniSTS
RH 3.4 Map16181.8UniSTS
Cytogenetic Map16p14UniSTS
RH129410  
Rat AssemblyChrPosition (strand)SourceJBrowse
mRatBN7.21618,755,482 - 18,755,688 (+)MAPPERmRatBN7.2
Rnor_6.01620,506,400 - 20,506,605NCBIRnor6.0
Rnor_5.01620,363,468 - 20,363,673UniSTSRnor5.0
RGSC_v3.41619,261,066 - 19,261,271UniSTSRGSC3.4
Celera1618,947,391 - 18,947,596UniSTS
RH 3.4 Map16181.8UniSTS
Cytogenetic Map16p14UniSTS
LSM4  
Rat AssemblyChrPosition (strand)SourceJBrowse
GRCr81618,790,146 - 18,790,284 (+)Marker Load Pipeline
mRatBN7.21618,756,161 - 18,756,298 (+)MAPPERmRatBN7.2
Rnor_6.01620,507,079 - 20,507,215NCBIRnor6.0
Rnor_5.01620,364,147 - 20,364,283UniSTSRnor5.0
RGSC_v3.41619,261,745 - 19,261,881UniSTSRGSC3.4
Celera1618,948,070 - 18,948,206UniSTS
Cytogenetic Map16p14UniSTS




alimentary part of gastrointestinal system
appendage
circulatory system
ectoderm
endocrine system
endoderm
exocrine system
hemolymphoid system
hepatobiliary system
integumental system
mesenchyme
mesoderm
nervous system
renal system
reproductive system
respiratory system
9 11 49 113 91 90 59 25 59 6 218 97 93 45 60 31



Ensembl Acc Id: ENSRNOT00000026567   ⟹   ENSRNOP00000026567
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,755,484 - 18,760,926 (-)Ensembl
Rnor_6.0 Ensembl1620,506,399 - 20,511,818 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000097247   ⟹   ENSRNOP00000095698
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,755,723 - 18,757,622 (-)Ensembl
Ensembl Acc Id: ENSRNOT00000119396   ⟹   ENSRNOP00000083403
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
mRatBN7.2 Ensembl1618,755,484 - 18,760,926 (-)Ensembl
RefSeq Acc Id: NM_001106073   ⟹   NP_001099543
RefSeq Status: PROVISIONAL
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,789,467 - 18,794,886 (-)NCBI
mRatBN7.21618,755,482 - 18,760,901 (-)NCBI
Rnor_6.01620,506,399 - 20,511,818 (-)NCBI
Rnor_5.01620,363,442 - 20,368,886 (-)NCBI
RGSC_v3.41619,261,065 - 19,266,484 (-)RGD
Celera1618,947,390 - 18,952,806 (-)RGD
Sequence:
RefSeq Acc Id: XM_039094317   ⟹   XP_038950245
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,789,466 - 18,794,792 (-)NCBI
mRatBN7.21618,755,481 - 18,760,807 (-)NCBI
RefSeq Acc Id: XM_039094318   ⟹   XP_038950246
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,790,506 - 18,795,164 (-)NCBI
mRatBN7.21618,756,521 - 18,761,106 (-)NCBI
RefSeq Acc Id: XM_063275158   ⟹   XP_063131228
Type: CODING
Position:
Rat AssemblyChrPosition (strand)Source
GRCr81618,789,466 - 18,794,919 (-)NCBI
1 to 9 of 9 rows
Protein RefSeqs NP_001099543 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950245 (Get FASTA)   NCBI Sequence Viewer  
  XP_038950246 (Get FASTA)   NCBI Sequence Viewer  
  XP_063131228 (Get FASTA)   NCBI Sequence Viewer  
GenBank Protein EDL90723 (Get FASTA)   NCBI Sequence Viewer  
  EDL90724 (Get FASTA)   NCBI Sequence Viewer  
Ensembl Protein ENSRNOP00000026567.4
  ENSRNOP00000083403.1
  ENSRNOP00000095698.1
1 to 9 of 9 rows
RefSeq Acc Id: NP_001099543   ⟸   NM_001106073
- UniProtKB: D4A2C6 (UniProtKB/TrEMBL),   A6KA13 (UniProtKB/TrEMBL)
- Sequence:
Ensembl Acc Id: ENSRNOP00000026567   ⟸   ENSRNOT00000026567
RefSeq Acc Id: XP_038950245   ⟸   XM_039094317
- Peptide Label: isoform X2
- UniProtKB: A6KA14 (UniProtKB/TrEMBL),   A0A8I5ZZ77 (UniProtKB/TrEMBL)
RefSeq Acc Id: XP_038950246   ⟸   XM_039094318
- Peptide Label: isoform X3
Ensembl Acc Id: ENSRNOP00000083403   ⟸   ENSRNOT00000119396
Sm

Name Modeler Protein Id AA Range Protein Structure
AF-D4A2C6-F1-model_v2 AlphaFold D4A2C6 1-138 view protein structure


eQTL   View at Phenogen
WGCNA   View at Phenogen
Tissue/Strain Expression   View at Phenogen

RGD ID:13700020
Promoter ID:EPDNEW_R10543
Type:initiation region
Name:Lsm4_1
Description:LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated
SO ACC ID:SO:0000170
Source:EPDNEW (Eukaryotic Promoter Database, http://epd.vital-it.ch/)
Experiment Methods:Single-end sequencing.
Position:
Rat AssemblyChrPosition (strand)Source
Rnor_6.01620,511,688 - 20,511,748EPDNEW


1 to 25 of 25 rows
Database
Acc Id
Source(s)
BioCyc Gene G2FUF-11797 BioCyc
Ensembl Genes ENSRNOG00000019572 Ensembl, UniProtKB/TrEMBL
Ensembl Transcript ENSRNOT00000026567.6 UniProtKB/TrEMBL
  ENSRNOT00000097247.1 UniProtKB/TrEMBL
  ENSRNOT00000119396.1 UniProtKB/TrEMBL
Gene3D-CATH 2.30.30.100 UniProtKB/TrEMBL
InterPro IPR047575 UniProtKB/TrEMBL
  Lsm4 UniProtKB/TrEMBL
  LSm4/Sm_D1/D3 UniProtKB/TrEMBL
  LSM_domain UniProtKB/TrEMBL
  LSM_related_domain UniProtKB/TrEMBL
KEGG Report rno:290647 UniProtKB/TrEMBL
NCBI Gene 290647 ENTREZGENE
PANTHER PTHR23338 UniProtKB/TrEMBL
Pfam LSM UniProtKB/TrEMBL
PhenoGen Lsm4 PhenoGen
PROSITE PS52002 UniProtKB/TrEMBL
RatGTEx ENSRNOG00000019572 RatGTEx
SMART SM00651 UniProtKB/TrEMBL
Superfamily-SCOP Sm_like_riboprot UniProtKB/TrEMBL
UniProt A0A8I5ZZ77 ENTREZGENE, UniProtKB/TrEMBL
  A0A8I6APJ0_RAT UniProtKB/TrEMBL
  A6KA13 ENTREZGENE, UniProtKB/TrEMBL
  A6KA14 ENTREZGENE, UniProtKB/TrEMBL
  D4A2C6 ENTREZGENE, UniProtKB/TrEMBL
1 to 25 of 25 rows


Date Current Symbol Current Name Previous Symbol Previous Name Description Reference Status
2015-07-09 Lsm4  LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated  Lsm4  LSM4 U6 small nuclear RNA and mRNA degradation associated  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2015-07-01 Lsm4  LSM4 U6 small nuclear RNA and mRNA degradation associated  Lsm4  LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)  Nomenclature updated to reflect human and mouse nomenclature 1299863 APPROVED
2008-04-30 Lsm4  LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae)   Lsm4_predicted  LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (predicted)  'predicted' is removed 2292626 APPROVED
2005-01-12 Lsm4_predicted  LSM4 homolog, U6 small nuclear RNA associated (S. cerevisiae) (predicted)      Symbol and Name status set to approved 70820 APPROVED