RGD Reference Report - The spliceosome: design principles of a dynamic RNP machine. - Rat Genome Database

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The spliceosome: design principles of a dynamic RNP machine.

Authors: Wahl, MC  Will, CL  Luhrmann, R 
Citation: Wahl MC, etal., Cell. 2009 Feb 20;136(4):701-18. doi: 10.1016/j.cell.2009.02.009.
RGD ID: 9686089
Pubmed: PMID:19239890   (View Abstract at PubMed)
DOI: DOI:10.1016/j.cell.2009.02.009   (Journal Full-text)

Ribonucleoproteins (RNPs) mediate key cellular functions such as gene expression and its regulation. Whereas most RNP enzymes are stable in composition and harbor preformed active sites, the spliceosome, which removes noncoding introns from precursor messenger RNAs (pre-mRNAs), follows fundamentally different strategies. In order to provide both accuracy to the recognition of reactive splice sites in the pre-mRNA and flexibility to the choice of splice sites during alternative splicing, the spliceosome exhibits exceptional compositional and structural dynamics that are exploited during substrate-dependent complex assembly, catalytic activation, and active site remodeling.



Molecular Pathway Annotations    Click to see Annotation Detail View

RGD Manual Annotations


  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
DDX23Humanspliceosome pathway   TAS  RGD 
Ddx23Ratspliceosome pathway   ISODDX23 (Homo sapiens) RGD 
Ddx23Mousespliceosome pathway   ISODDX23 (Homo sapiens) RGD 
HNRNPA1Humanspliceosome pathway   TAS  RGD 
HNRNPA3Humanspliceosome pathway   TAS  RGD 
HNRNPCHumanspliceosome pathway   TAS  RGD 
HNRNPKHumanspliceosome pathway   TAS  RGD 
HNRNPMHumanspliceosome pathway   TAS  RGD 
HNRNPUHumanspliceosome pathway   TAS  RGD 
Hnrnpa1Ratspliceosome pathway   ISOHNRNPA1 (Homo sapiens) RGD 
Hnrnpa1Mousespliceosome pathway   ISOHNRNPA1 (Homo sapiens) RGD 
Hnrnpa3Mousespliceosome pathway   ISOHNRNPA3 (Homo sapiens) RGD 
HnrnpcRatspliceosome pathway   ISOHNRNPC (Homo sapiens) RGD 
HnrnpcMousespliceosome pathway   ISOHNRNPC (Homo sapiens) RGD 
HnrnpkRatspliceosome pathway   ISOHNRNPK (Homo sapiens) RGD 
HnrnpkMousespliceosome pathway   ISOHNRNPK (Homo sapiens) RGD 
HnrnpmRatspliceosome pathway   ISOHNRNPM (Homo sapiens) RGD 
HnrnpmMousespliceosome pathway   ISOHNRNPM (Homo sapiens) RGD 
HnrnpuRatspliceosome pathway   ISOHNRNPU (Homo sapiens) RGD 
HnrnpuMousespliceosome pathway   ISOHNRNPU (Homo sapiens) RGD 
LSM2Humanspliceosome pathway   TAS  RGD 
LSM3Humanspliceosome pathway   TAS  RGD 
LSM4Humanspliceosome pathway   TAS  RGD 
LSM5Humanspliceosome pathway   TAS  RGD 
LSM6Humanspliceosome pathway   TAS  RGD 
LSM7Humanspliceosome pathway   TAS  RGD 
LSM8Humanspliceosome pathway   TAS  RGD 
Lsm2Ratspliceosome pathway   ISOLSM2 (Homo sapiens) RGD 
Lsm2Mousespliceosome pathway   ISOLSM2 (Homo sapiens) RGD 
Lsm3Ratspliceosome pathway   ISOLSM3 (Homo sapiens) RGD 
Lsm3Mousespliceosome pathway   ISOLSM3 (Homo sapiens) RGD 
Lsm4Ratspliceosome pathway   ISOLSM4 (Homo sapiens) RGD 
Lsm4Mousespliceosome pathway   ISOLSM4 (Homo sapiens) RGD 
Lsm5Mousespliceosome pathway   ISOLSM5 (Homo sapiens) RGD 
Lsm6Mousespliceosome pathway   ISOLSM6 (Homo sapiens) RGD 
Lsm6Ratspliceosome pathway   ISOLSM6 (Homo sapiens) RGD 
Lsm7Ratspliceosome pathway   ISOLSM7 (Homo sapiens) RGD 
Lsm8Ratspliceosome pathway   ISOLSM8 (Homo sapiens) RGD 
Lsm8Mousespliceosome pathway   ISOLSM8 (Homo sapiens) RGD 
PRPF3Humanspliceosome pathway   TAS  RGD 
PRPF31Humanspliceosome pathway   TAS  RGD 
PRPF4Humanspliceosome pathway   TAS  RGD 
PRPF6Humanspliceosome pathway   TAS  RGD 
Prpf3Ratspliceosome pathway   ISOPRPF3 (Homo sapiens) RGD 
Prpf3Mousespliceosome pathway   ISOPRPF3 (Homo sapiens) RGD 
Prpf31Ratspliceosome pathway   ISOPRPF31 (Homo sapiens) RGD 
Prpf31Mousespliceosome pathway   ISOPRPF31 (Homo sapiens) RGD 
Prpf4Ratspliceosome pathway   ISOPRPF4 (Homo sapiens) RGD 
Prpf4Mousespliceosome pathway   ISOPRPF4 (Homo sapiens) RGD 
Prpf6Ratspliceosome pathway   ISOPRPF6 (Homo sapiens) RGD 
Prpf6Mousespliceosome pathway   ISOPRPF6 (Homo sapiens) RGD 
RBMXHumanspliceosome pathway   TAS  RGD 
RbmxMousespliceosome pathway   ISORBMX (Homo sapiens) RGD 
RbmxRatspliceosome pathway   ISORBMX (Homo sapiens) RGD 
SF1Humanspliceosome pathway   TAS  RGD 
SNRPBHumanspliceosome pathway   TAS  RGD 
SNRPD1Humanspliceosome pathway   TAS  RGD 
SNRPD2Humanspliceosome pathway   TAS  RGD 
SNRPD3Humanspliceosome pathway   TAS  RGD 
SNRPEHumanspliceosome pathway   TAS  RGD 
SNRPFHumanspliceosome pathway   TAS  RGD 
SNRPGHumanspliceosome pathway   TAS  RGD 
SNU13Humanspliceosome pathway   TAS  RGD 
SRSF1Humanspliceosome pathway   TAS  RGD 
SRSF10Humanspliceosome pathway   TAS  RGD 
SRSF3Humanspliceosome pathway   TAS  RGD 
SRSF4Humanspliceosome pathway   TAS  RGD 
SRSF5Humanspliceosome pathway   TAS  RGD 
SRSF6Humanspliceosome pathway   TAS  RGD 
SRSF7Humanspliceosome pathway   TAS  RGD 
SRSF9Humanspliceosome pathway   TAS  RGD 
Sf1Ratspliceosome pathway   ISOSF1 (Homo sapiens) RGD 
Sf1Mousespliceosome pathway   ISOSF1 (Homo sapiens) RGD 
SnrpbRatspliceosome pathway   ISOSNRPB (Homo sapiens) RGD 
SnrpbMousespliceosome pathway   ISOSNRPB (Homo sapiens) RGD 
Snrpd1Ratspliceosome pathway   ISOSNRPD1 (Homo sapiens) RGD 
Snrpd1Mousespliceosome pathway   ISOSNRPD1 (Homo sapiens) RGD 
Snrpd2Mousespliceosome pathway   ISOSNRPD2 (Homo sapiens) RGD 
Snrpd2Ratspliceosome pathway   ISOSNRPD2 (Homo sapiens) RGD 
Snrpd3Ratspliceosome pathway   ISOSNRPD3 (Homo sapiens) RGD 
Snrpd3Mousespliceosome pathway   ISOSNRPD3 (Homo sapiens) RGD 
SnrpeMousespliceosome pathway   ISOSNRPE (Homo sapiens) RGD 
SnrpeRatspliceosome pathway   ISOSNRPE (Homo sapiens) RGD 
SnrpfRatspliceosome pathway   ISOSNRPF (Homo sapiens) RGD 
SnrpfMousespliceosome pathway   ISOSNRPF (Homo sapiens) RGD 
SnrpgRatspliceosome pathway   ISOSNRPG (Homo sapiens) RGD 
SnrpgMousespliceosome pathway   ISOSNRPG (Homo sapiens) RGD 
Snu13Ratspliceosome pathway   ISOSNU13 (Homo sapiens) RGD 
Snu13Mousespliceosome pathway   ISOSNU13 (Homo sapiens) RGD 
Srsf1Ratspliceosome pathway   ISOSRSF1 (Homo sapiens) RGD 
Srsf1Mousespliceosome pathway   ISOSRSF1 (Homo sapiens) RGD 
Srsf10Ratspliceosome pathway   ISOSRSF10 (Homo sapiens) RGD 
Srsf10Mousespliceosome pathway   ISOSRSF10 (Homo sapiens) RGD 
Srsf3Mousespliceosome pathway   ISOSRSF3 (Homo sapiens) RGD 
Srsf4Ratspliceosome pathway   ISOSRSF4 (Homo sapiens) RGD 
Srsf4Mousespliceosome pathway   ISOSRSF4 (Homo sapiens) RGD 
Srsf5Ratspliceosome pathway   ISOSRSF5 (Homo sapiens) RGD 
Srsf5Mousespliceosome pathway   ISOSRSF5 (Homo sapiens) RGD 
Srsf6Ratspliceosome pathway   ISOSRSF6 (Homo sapiens) RGD 
Srsf6Mousespliceosome pathway   ISOSRSF6 (Homo sapiens) RGD 
Srsf7Ratspliceosome pathway   ISOSRSF7 (Homo sapiens) RGD 
Srsf7Mousespliceosome pathway   ISOSRSF7 (Homo sapiens) RGD 
Srsf9Ratspliceosome pathway   ISOSRSF9 (Homo sapiens) RGD 
Srsf9Mousespliceosome pathway   ISOSRSF9 (Homo sapiens) RGD 
TXNL4AHumanspliceosome pathway   TAS  RGD 
Txnl4aMousespliceosome pathway   ISOTXNL4A (Homo sapiens) RGD 
U2AF1Humanspliceosome pathway   TAS  RGD 
U2AF2Humanspliceosome pathway   TAS  RGD 
U2af1Ratspliceosome pathway   ISOU2AF1 (Homo sapiens) RGD 
U2af1Mousespliceosome pathway   ISOU2AF1 (Homo sapiens) RGD 
U2af2Ratspliceosome pathway   ISOU2AF2 (Homo sapiens) RGD 
U2af2Mousespliceosome pathway   ISOU2AF2 (Homo sapiens) RGD 
Objects Annotated

Genes (Rattus norvegicus)
Ddx23  (DEAD-box helicase 23)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpc  (heterogeneous nuclear ribonucleoprotein C)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hnrnpm  (heterogeneous nuclear ribonucleoprotein M)
Hnrnpu  (heterogeneous nuclear ribonucleoprotein U)
Lsm2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm7  (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm8  (LSM8 homolog, U6 small nuclear RNA associated)
Prpf3  (pre-mRNA processing factor 3)
Prpf31  (pre-mRNA processing factor 31)
Prpf4  (pre-mRNA splicing tri-snRNP complex factor PRPF4)
Prpf6  (pre-mRNA processing factor 6)
Rbmx  (RNA binding motif protein, X-linked)
Sf1  (splicing factor 1)
Snrpb  (small nuclear ribonucleoprotein polypeptides B and B1)
Snrpd1  (small nuclear ribonucleoprotein D1 polypeptide)
Snrpd2  (small nuclear ribonucleoprotein D2 polypeptide)
Snrpd3  (small nuclear ribonucleoprotein D3 polypeptide)
Snrpe  (small nuclear ribonucleoprotein polypeptide E)
Snrpf  (small nuclear ribonucleoprotein polypeptide F)
Snrpg  (small nuclear ribonucleoprotein polypeptide G)
Snu13  (small nuclear ribonucleoprotein 13)
Srsf1  (serine and arginine rich splicing factor 1)
Srsf10  (serine and arginine rich splicing factor 10)
Srsf4  (serine and arginine rich splicing factor 4)
Srsf5  (serine and arginine rich splicing factor 5)
Srsf6  (serine and arginine rich splicing factor 6)
Srsf7  (serine and arginine rich splicing factor 7)
Srsf9  (serine and arginine rich splicing factor 9)
U2af1  (U2 small nuclear RNA auxiliary factor 1)
U2af2  (U2 small nuclear RNA auxiliary factor 2)

Genes (Mus musculus)
Ddx23  (DEAD box helicase 23)
Hnrnpa1  (heterogeneous nuclear ribonucleoprotein A1)
Hnrnpa3  (heterogeneous nuclear ribonucleoprotein A3)
Hnrnpc  (heterogeneous nuclear ribonucleoprotein C)
Hnrnpk  (heterogeneous nuclear ribonucleoprotein K)
Hnrnpm  (heterogeneous nuclear ribonucleoprotein M)
Hnrnpu  (heterogeneous nuclear ribonucleoprotein U)
Lsm2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm5  (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
Lsm8  (LSM8 homolog, U6 small nuclear RNA associated)
Prpf3  (pre-mRNA processing factor 3)
Prpf31  (pre-mRNA processing factor 31)
Prpf4  (pre-mRNA processing factor 4)
Prpf6  (pre-mRNA splicing factor 6)
Rbmx  (RNA binding motif protein, X chromosome)
Sf1  (splicing factor 1)
Snrpb  (small nuclear ribonucleoprotein B)
Snrpd1  (small nuclear ribonucleoprotein D1)
Snrpd2  (small nuclear ribonucleoprotein D2)
Snrpd3  (small nuclear ribonucleoprotein D3)
Snrpe  (small nuclear ribonucleoprotein E)
Snrpf  (small nuclear ribonucleoprotein polypeptide F)
Snrpg  (small nuclear ribonucleoprotein polypeptide G)
Snu13  (SNU13 homolog, small nuclear ribonucleoprotein (U4/U6.U5))
Srsf1  (serine and arginine-rich splicing factor 1)
Srsf10  (serine and arginine-rich splicing factor 10)
Srsf3  (serine and arginine-rich splicing factor 3)
Srsf4  (serine and arginine-rich splicing factor 4)
Srsf5  (serine and arginine-rich splicing factor 5)
Srsf6  (serine and arginine-rich splicing factor 6)
Srsf7  (serine and arginine-rich splicing factor 7)
Srsf9  (serine and arginine-rich splicing factor 9)
Txnl4a  (thioredoxin-like 4A)
U2af1  (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 1)
U2af2  (U2 small nuclear ribonucleoprotein auxiliary factor (U2AF) 2)

Genes (Homo sapiens)
DDX23  (DEAD-box helicase 23)
HNRNPA1  (heterogeneous nuclear ribonucleoprotein A1)
HNRNPA3  (heterogeneous nuclear ribonucleoprotein A3)
HNRNPC  (heterogeneous nuclear ribonucleoprotein C)
HNRNPK  (heterogeneous nuclear ribonucleoprotein K)
HNRNPM  (heterogeneous nuclear ribonucleoprotein M)
HNRNPU  (heterogeneous nuclear ribonucleoprotein U)
LSM2  (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM3  (LSM3 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM4  (LSM4 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM5  (LSM5 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM6  (LSM6 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM7  (LSM7 homolog, U6 small nuclear RNA and mRNA degradation associated)
LSM8  (LSM8 homolog, U6 small nuclear RNA associated)
PRPF3  (pre-mRNA processing factor 3)
PRPF31  (pre-mRNA processing factor 31)
PRPF4  (pre-mRNA splicing tri-snRNP complex factor PRPF4)
PRPF6  (pre-mRNA processing factor 6)
RBMX  (RNA binding motif protein X-linked)
SF1  (splicing factor 1)
SNRPB  (small nuclear ribonucleoprotein polypeptides B and B1)
SNRPD1  (small nuclear ribonucleoprotein D1 polypeptide)
SNRPD2  (small nuclear ribonucleoprotein D2 polypeptide)
SNRPD3  (small nuclear ribonucleoprotein D3 polypeptide)
SNRPE  (small nuclear ribonucleoprotein polypeptide E)
SNRPF  (small nuclear ribonucleoprotein polypeptide F)
SNRPG  (small nuclear ribonucleoprotein polypeptide G)
SNU13  (small nuclear ribonucleoprotein 13)
SRSF1  (serine and arginine rich splicing factor 1)
SRSF10  (serine and arginine rich splicing factor 10)
SRSF3  (serine and arginine rich splicing factor 3)
SRSF4  (serine and arginine rich splicing factor 4)
SRSF5  (serine and arginine rich splicing factor 5)
SRSF6  (serine and arginine rich splicing factor 6)
SRSF7  (serine and arginine rich splicing factor 7)
SRSF9  (serine and arginine rich splicing factor 9)
TXNL4A  (thioredoxin like 4A)
U2AF1  (U2 small nuclear RNA auxiliary factor 1)
U2AF2  (U2 small nuclear RNA auxiliary factor 2)


Additional Information