RGD Reference Report - Association of anti-modified citrullinated vimentin with subclinical atherosclerosis in early rheumatoid arthritis compared with anti-cyclic citrullinated peptide. - Rat Genome Database

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Association of anti-modified citrullinated vimentin with subclinical atherosclerosis in early rheumatoid arthritis compared with anti-cyclic citrullinated peptide.

Authors: El-Barbary, AM  Kassem, EM  El-Sergany, MA  Essa, SA  Eltomey, MA 
Citation: El-Barbary AM, etal., J Rheumatol. 2011 May;38(5):828-34. Epub 2011 Mar 1.
RGD ID: 6480618
Pubmed: PMID:21362765   (View Abstract at PubMed)
DOI: DOI:10.3899/jrheum.101143   (Journal Full-text)

OBJECTIVE: To investigate anti-modified citrullinated vimentin (anti-MCV) in early rheumatoid arthritis (RA), including correlation with disease activity and cardiovascular risk factors, compared with anti-cyclic citrullinated peptides (anti-CCP3). METHODS: Anti-MCV and anti-CCP3 concentrations were measured in 100 patients with early RA and 100 healthy controls at baseline to determine sensitivity and specificity. Patients received methotrexate (MTX) 0.2 mg/kg/week plus prednisone 10 mg/day. Anti-MCV, anti-CCP3, rheumatoid factor (RF), Disease Activity Score for 28 joints (DAS-28), lipid profile, erythrocyte sedimentation rate (ESR), high-sensitivity C-reactive protein assay (hsCRP), homeostasis model assessment for insulin resistance (HOMA-IR) index, tumor necrosis factor-alpha (TNF-alpha), interleukin 6 (IL-6), and carotid intima-media thickness (cIMT) were measured before and after 12 months of treatment. RESULTS: The sensitivity and specificity for anti-MCV antibody were 75% and 90%, respectively, and for anti-CCP3 antibody 71% and 96%. Serum anti-MCV and serum anti-CCP3 levels at baseline were positively correlated with hsCRP, IL-6, HOMA-IR index, serum RF levels (p < 0.001), and cIMT (p < 0.05). Serum anti-MCV was positively correlated with serum anti-CCP3 levels. There were significant positive correlations between the percentage of changes of anti-MCV levels versus changes in DAS-28, ESR, hsCRP, atherogenic ratios (TC/HDL-C and LDL-C/HDL-C), apolipoprotein A-I, IL-6, TNF-alpha, HOMA-IR index, and cIMT. These correlations were not found between changes in anti-CCP3 levels compared to clinical, laboratory, and radiological variables. CONCLUSION: Anti-MCV was as sensitive as anti-CCP3 in diagnosing early RA. Anti-MCV testing appears to be useful for monitoring associated subclinical atherosclerosis in early RA.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
VIMHumanatherosclerosis  IDA associated with arthritis and rheumatoidRGD 
VimRatatherosclerosis  ISOVIM (Homo sapiens)associated with arthritis and rheumatoidRGD 
VimMouseatherosclerosis  ISOVIM (Homo sapiens)associated with arthritis and rheumatoidRGD 

Objects Annotated

Genes (Rattus norvegicus)
Vim  (vimentin)

Genes (Mus musculus)
Vim  (vimentin)

Genes (Homo sapiens)
VIM  (vimentin)


Additional Information