RGD Reference Report - Early atherosclerosis and IgG2 to bacteria are associated with FcgammaRIIa genotype in non-smokers. - Rat Genome Database

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Early atherosclerosis and IgG2 to bacteria are associated with FcgammaRIIa genotype in non-smokers.

Authors: Sampi, M  Ukkola, O  Paivansalo, M  Kesaniemi, YA  Horkko, S 
Citation: Sampi M, etal., Eur J Clin Invest. 2009 Jun;39(6):517-26.
RGD ID: 5147923
Pubmed: PMID:19490059   (View Abstract at PubMed)
DOI: DOI:10.1111/j.1365-2362.2009.02138.x   (Journal Full-text)

BACKGROUND: Involvement of low density lipoprotein (LDL) immune complexes (ICs) in atherogenesis has been proposed. Human FcgammaRIIa receptor (CD32) plays a crucial role in the phagocytosis of IgG(2) ICs and a functional point mutation 131His/Arg diminishes IgG(2) binding to the receptor. STUDY DESIGN: We examined FcgammaRIIa-131His/Arg polymorphism, IgG(2) antibody titres to oxidized low-density lipoprotein (OxLDL) and Streptococcus pneumoniae cell wall polysaccharide (CWPS) and subclinical atherosclerosis in a large cohort of Finnish subjects (n = 1041). RESULTS: Non-smoking subjects with homozygous 131His/His genotype had more premature atherosclerosis (P = 0.004) and higher IgG(2) to bacterial CWPS (P = 0.002) compared with other genotypes. Smoking subjects had significantly higher intima-media thickness (IMT) than that of non-smokers (P < 0.001) and genotype-dependent associations were indistinct. There was no association between FcgammaRIIa genotype and antibody titres to OxLDL. CONCLUSIONS: Our data demonstrate that FcgammaRIIa 131His/Arg polymorphism is associated with subclinical atherosclerosis in non-smoking subjects. Furthermore, FcgammaRIIa genotype is associated with IgG(2) titres to bacterial CWPS, but not to OxLDL. These data propose possible involvement of FcgammaRIIa receptor in atherogenesis.

RGD Manual Disease Annotations    Click to see Annotation Detail View

Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
FCGR2AHumanatherosclerosis onsetIAGP DNA:polymorphism: :p.H131R (human)RGD 
Fcgr2aRatatherosclerosis onsetISOFCGR2A (Homo sapiens)DNA:polymorphism: :p.H131R (human)RGD 

Objects Annotated

Genes (Rattus norvegicus)
Fcgr2a  (Fc gamma receptor 2A)

Genes (Homo sapiens)
FCGR2A  (Fc gamma receptor IIa)

Additional Information