RGD Reference Report - [Effects of n-3 polyunsaturated fatty acids on hemorheology and coagulation in atherosclerotic rats]. - Rat Genome Database

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[Effects of n-3 polyunsaturated fatty acids on hemorheology and coagulation in atherosclerotic rats].

Authors: Yang, YB  Li, P  Liu, ML 
Citation: Yang YB, etal., Zhonghua Yi Xue Za Zhi. 2010 Jul 27;90(28):2004-7.
RGD ID: 7387315
Pubmed: PMID:20979870   (View Abstract at PubMed)

OBJECTIVE: To investigate the effect of n-3 polyunsaturated fatty acids (n-3PUFAs) on the hemorheology and coagulation function of high-fat induced atherosclerotic rats and understand the underlying mechanism. METHODS: Twenty-four Wistar rats were assigned randomly into 3 groups: normal control, model and n-3PUFAs treatment (n = 8 in each). The rats in model and treatment groups were injected with a single dose of vitamin D(3) (600,000 U/kg) and fed with a high-fat diet. Basic chow was provided for normal control group. After a 6-week high-fat diet, the rats in treatment group were treated with n-3PUFAs at 250 mgxkg(-1)xd(-1) by gastric tube. The serum lipid, aortal morphological changes, hemorheology, coagulation, nitric oxide (NO), total antioxidant capacity (T-AOC) and malonaldehyde (MDA) were detected after a 6-week n-3PUFAs diet. RESULTS: Compared with control group, model group rat total cholesterol (TC), low density cholesterol (LDL-C), plasma viscosity, whole blood viscosity, fibrinogen (FIB) and MDA concentrations were higher (all P < 0.05), but activated partial thromboplastin time (APTT), prothrombin time (PT), thrombin time (TT), erythrocyte deformation index(DI), plasma NO and T-AOC were lower (all P < 0.05). Compared with model group, n-3PUFAs could reduce blood lipid levels, inhibit atherosclerotic plaque formation, decrease plasma viscosity [(1.58 +/- 0.23) mPa.s vs (1.81 +/- 0.16) mPa.s], whole blood viscosity [(4.76 +/- 0.42) mPa.s vs (5.47 +/- 0.41) mPa.s, (4.24 +/- 0.32) mPa.s vs (4.91 +/- 0.39) mPa.s, (4.04 +/- 0.29) mPa.s vs (4.58 +/- 0.33) mPa.s] and FIB [(2.45 +/- 0.12)g/L vs (2.65 +/- 0.13) g/L], lower MDA content [(10.1 +/- 0.7) micromol/ml vs (11.2 +/- 0.6) micromol/ml], prolong APTT, PT and TT [(29.04 +/- 0.49)s vs (26.46 +/- 0.25) s, (13.86 +/- 0.55) s vs (10.71 +/- 0.34) s, (23.05 +/- 0.24) s vs (20.90 +/- 0.68) s], increase erythrocyte DI (0.35 +/- 0.01 vs 0.31 +/- 0.02), plasma NO [(3.9 +/- 0.7) nmol/ml vs (2.8 +/- 0.7) nmol/ml] and T-AOC levels [(8.0 +/- 0.6) U/ml vs (6.7 +/- 0.6) U/ml]of atherosclerotic rats (all P < 0.05). CONCLUSION: n-3PUFAs may improve hemorheology and coagulation of atherosclerotic rats, reduce oxidative stress, improve endothelial function and inhibit atherosclerotic plaque formation.



RGD Manual Disease Annotations    Click to see Annotation Detail View

  
Object SymbolSpeciesTermQualifierEvidenceWithNotesSourceOriginal Reference(s)
F2Ratatherosclerosis treatmentIDA  RGD 
F2Mouseatherosclerosis treatmentISOF2 (Rattus norvegicus) RGD 
F2Humanatherosclerosis treatmentISOF2 (Rattus norvegicus) RGD 

Objects Annotated

Genes (Rattus norvegicus)
F2  (coagulation factor II, thrombin)

Genes (Mus musculus)
F2  (coagulation factor II)

Genes (Homo sapiens)
F2  (coagulation factor II, thrombin)


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