(25R)-cholest-5-ene-3beta,26-diol affects abundance ISO Npc1 (Mus musculus) 6480464 NPC1 protein affects the abundance of 27-hydroxycholesterol CTD PMID:18483620 1,1,1-Trichloro-2-(o-chlorophenyl)-2-(p-chlorophenyl)ethane increases expression ISO NPC1 (Homo sapiens) 6480464 o and p'-DDT results in increased expression of NPC1 mRNA CTD PMID:18204070 1,1-dichloroethene increases expression ISO Npc1 (Mus musculus) 6480464 vinylidene chloride results in increased expression of NPC1 mRNA CTD PMID:26682919 17beta-estradiol increases expression EXP 6480464 Estradiol results in increased expression of NPC1 mRNA CTD PMID:32145629 2,2',4,4',5,5'-hexachlorobiphenyl multiple interactions ISO Npc1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO Npc1 (Mus musculus) 6480464 2 more ... CTD PMID:30294300 2,2',4,4'-Tetrabromodiphenyl ether affects expression ISO NPC1 (Homo sapiens) 6480464 2 more ... CTD PMID:31173147 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO NPC1 (Homo sapiens) 6480464 AHR protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein] and ARNT protein affects the reaction [Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein] CTD PMID:19131362 2,3,7,8-tetrachlorodibenzodioxine multiple interactions ISO Npc1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:21762485 more ... 2,3,7,8-tetrachlorodibenzodioxine decreases expression EXP 6480464 Tetrachlorodibenzodioxin results in decreased expression of NPC1 mRNA CTD PMID:21724226 2,3,7,8-tetrachlorodibenzodioxine increases expression ISO NPC1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in increased expression of NPC1 mRNA CTD PMID:15056799 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO NPC1 (Homo sapiens) 6480464 Tetrachlorodibenzodioxin results in decreased expression of NPC1 mRNA and Tetrachlorodibenzodioxin results in decreased expression of NPC1 protein CTD PMID:19131362 2-methylcholine affects expression ISO NPC1 (Homo sapiens) 6480464 beta-methylcholine affects the expression of NPC1 mRNA CTD PMID:21179406 26-hydroxycholesterol affects abundance ISO Npc1 (Mus musculus) 6480464 NPC1 protein affects the abundance of 27-hydroxycholesterol CTD PMID:18483620 3-isobutyl-1-methyl-7H-xanthine multiple interactions ISO NPC1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA CTD PMID:28628672 4,4'-diaminodiphenylmethane decreases expression ISO Npc1 (Mus musculus) 6480464 4 and 4'-diaminodiphenylmethane results in decreased expression of NPC1 mRNA CTD PMID:18648102 4,4'-sulfonyldiphenol multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPC1 mRNA CTD PMID:36041667 4-(N-nitrosomethylamino)-1-(3-pyridyl)butan-1-one increases expression ISO NPC1 (Homo sapiens) 6480464 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone results in increased expression of NPC1 mRNA CTD PMID:19038236 6-propyl-2-thiouracil affects expression EXP 6480464 Propylthiouracil affects the expression of NPC1 mRNA CTD PMID:24780913 6-propyl-2-thiouracil increases expression EXP 6480464 Propylthiouracil results in increased expression of NPC1 mRNA CTD PMID:30047161 acetamide decreases expression EXP 6480464 acetamide results in decreased expression of NPC1 mRNA CTD PMID:31881176 aflatoxin B1 increases expression ISO Npc1 (Mus musculus) 6480464 Aflatoxin B1 results in increased expression of NPC1 mRNA CTD PMID:19770486 aflatoxin B1 decreases methylation ISO NPC1 (Homo sapiens) 6480464 Aflatoxin B1 results in decreased methylation of NPC1 intron CTD PMID:30157460 aflatoxin B1 increases expression ISO NPC1 (Homo sapiens) 6480464 Aflatoxin B1 results in increased expression of NPC1 mRNA CTD PMID:27153756 Aflatoxin B2 alpha decreases methylation ISO NPC1 (Homo sapiens) 6480464 aflatoxin B2 results in decreased methylation of NPC1 intron CTD PMID:30157460 ammonium chloride affects expression EXP 6480464 Ammonium Chloride affects the expression of NPC1 mRNA CTD PMID:16483693 antimycin A decreases expression ISO NPC1 (Homo sapiens) 6480464 Antimycin A results in decreased expression of NPC1 mRNA CTD PMID:33512557 Archazolid B increases expression ISO NPC1 (Homo sapiens) 6480464 archazolid B results in increased expression of NPC1 mRNA CTD PMID:25218289 aristolochic acid A increases expression ISO NPC1 (Homo sapiens) 6480464 aristolochic acid I results in increased expression of NPC1 mRNA CTD PMID:33212167 arsenous acid decreases expression ISO NPC1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NPC1 protein CTD PMID:25419056 atrazine decreases expression ISO Npc1 (Mus musculus) 6480464 Atrazine results in decreased expression of NPC1 mRNA CTD PMID:33463082 benzene increases expression ISO NPC1 (Homo sapiens) 6480464 Benzene results in increased expression of NPC1 mRNA CTD PMID:19162166 benzo[a]pyrene decreases expression ISO Npc1 (Mus musculus) 6480464 Benzo(a)pyrene results in decreased expression of NPC1 mRNA CTD PMID:19131362 benzo[a]pyrene affects methylation ISO NPC1 (Homo sapiens) 6480464 Benzo(a)pyrene affects the methylation of NPC1 promoter CTD PMID:27901495 benzo[a]pyrene decreases expression ISO NPC1 (Homo sapiens) 6480464 Benzo(a)pyrene results in decreased expression of NPC1 mRNA and Benzo(a)pyrene results in decreased expression of NPC1 protein CTD PMID:19131362 benzo[a]pyrene diol epoxide I decreases expression ISO NPC1 (Homo sapiens) 6480464 7 more ... CTD PMID:19150397 bis(2-ethylhexyl) phthalate multiple interactions ISO Npc1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A decreases expression ISO NPC1 (Homo sapiens) 6480464 bisphenol A results in decreased expression of NPC1 mRNA CTD PMID:20678512 bisphenol A multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPC1 mRNA CTD PMID:36041667 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of NPC1 mRNA CTD PMID:34947998 bisphenol A affects expression ISO NPC1 (Homo sapiens) 6480464 bisphenol A affects the expression of NPC1 mRNA CTD PMID:30903817 bisphenol A increases expression ISO NPC1 (Homo sapiens) 6480464 bisphenol A results in increased expression of NPC1 mRNA and bisphenol A results in increased expression of NPC1 protein CTD PMID:29275510 and PMID:34186270 bisphenol A multiple interactions ISO Npc1 (Mus musculus) 6480464 [Tetrachlorodibenzodioxin co-treated with 2 more ... CTD PMID:28433925 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of NPC1 mRNA CTD PMID:25181051 Bisphenol B increases expression ISO NPC1 (Homo sapiens) 6480464 bisphenol B results in increased expression of NPC1 protein CTD PMID:34186270 bisphenol F multiple interactions ISO NPC1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA CTD PMID:28628672 bisphenol F multiple interactions EXP 6480464 [bisphenol A co-treated with bisphenol F co-treated with bis(4-hydroxyphenyl)sulfone] results in decreased expression of NPC1 mRNA CTD PMID:36041667 bisphenol F increases expression ISO NPC1 (Homo sapiens) 6480464 bisphenol F results in increased expression of NPC1 protein CTD PMID:34186270 cadmium atom increases expression EXP 6480464 Cadmium results in increased expression of NPC1 mRNA CTD PMID:12890491 cadmium atom decreases expression ISO Npc1 (Mus musculus) 6480464 Cadmium results in decreased expression of NPC1 mRNA CTD PMID:24067728 capsaicin increases expression ISO NPC1 (Homo sapiens) 6480464 Capsaicin results in increased expression of NPC1 mRNA CTD PMID:18533110 and PMID:36044967 carbon nanotube increases expression ISO Npc1 (Mus musculus) 6480464 Nanotubes more ... CTD PMID:25554681 and PMID:25620056 carbon nanotube increases expression ISO NPC1 (Homo sapiens) 6480464 Nanotubes and Carbon results in increased expression of NPC1 mRNA CTD PMID:24389112 chlordecone increases expression ISO Npc1 (Mus musculus) 6480464 Chlordecone results in increased expression of NPC1 mRNA CTD PMID:29980752 chloropicrin increases expression ISO NPC1 (Homo sapiens) 6480464 chloropicrin results in increased expression of NPC1 mRNA CTD PMID:26352163 cholesterol increases secretion ISO NPC1 (Homo sapiens) 6480464 NPC1 protein results in increased secretion of Cholesterol CTD PMID:16174794 cholesterol affects localization ISO Npc1 (Mus musculus) 6480464 NPC1 affects the localization of Cholesterol CTD PMID:12183525 cholesterol affects abundance ISO Npc1 (Mus musculus) 6480464 NPC1 protein affects the abundance of Cholesterol CTD PMID:18483620 cholesterol multiple interactions ISO NPC1 (Homo sapiens) 6480464 Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Cholesterol] CTD PMID:16174794 ciglitazone multiple interactions ISO NPC1 (Homo sapiens) 6480464 [ciglitazone binds to PPARG protein] which results in increased expression of NPC1 mRNA CTD PMID:16197558 clobetasol increases expression ISO Npc1 (Mus musculus) 6480464 Clobetasol results in increased expression of NPC1 mRNA CTD PMID:27462272 cobalt dichloride increases expression ISO NPC1 (Homo sapiens) 6480464 cobaltous chloride results in increased expression of NPC1 mRNA CTD PMID:19320972 and PMID:19376846 copper atom multiple interactions ISO NPC1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of NPC1 mRNA CTD PMID:20971185 copper atom increases abundance ISO Npc1 (Mus musculus) 6480464 NPC1 gene mutant form results in increased abundance of Copper CTD PMID:24901380 copper atom multiple interactions ISO Npc1 (Mus musculus) 6480464 Copper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of CP mRNA] and Copper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of MT1 mRNA] CTD PMID:24901380 copper atom affects abundance ISO Npc1 (Mus musculus) 6480464 NPC1 affects the abundance of Copper and NPC1 protein affects the abundance of Copper CTD PMID:22216111 and PMID:22526561 copper(0) multiple interactions ISO NPC1 (Homo sapiens) 6480464 [NSC 689534 binds to Copper] which results in increased expression of NPC1 mRNA CTD PMID:20971185 copper(0) multiple interactions ISO Npc1 (Mus musculus) 6480464 Copper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of CP mRNA] and Copper deficiency inhibits the reaction [NPC1 gene mutant form results in increased expression of MT1 mRNA] CTD PMID:24901380 copper(0) increases abundance ISO Npc1 (Mus musculus) 6480464 NPC1 gene mutant form results in increased abundance of Copper CTD PMID:24901380 copper(0) affects abundance ISO Npc1 (Mus musculus) 6480464 NPC1 affects the abundance of Copper and NPC1 protein affects the abundance of Copper CTD PMID:22216111 and PMID:22526561 copper(II) sulfate increases expression ISO NPC1 (Homo sapiens) 6480464 Copper Sulfate results in increased expression of NPC1 mRNA CTD PMID:19549813 crocidolite asbestos increases expression ISO NPC1 (Homo sapiens) 6480464 Asbestos and Crocidolite results in increased expression of NPC1 mRNA CTD PMID:18687144 crocidolite asbestos affects expression ISO NPC1 (Homo sapiens) 6480464 Asbestos and Crocidolite affects the expression of NPC1 mRNA CTD PMID:25757056 Cuprizon decreases expression EXP 6480464 Cuprizone results in decreased expression of NPC1 mRNA CTD PMID:27523638 cyclosporin A increases expression ISO Npc1 (Mus musculus) 6480464 Cyclosporine results in increased expression of NPC1 mRNA CTD PMID:23830897 cyclosporin A increases expression ISO NPC1 (Homo sapiens) 6480464 Cyclosporine results in increased expression of NPC1 mRNA CTD PMID:20106945 more ... daunorubicin multiple interactions ISO NPC1 (Homo sapiens) 6480464 Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin] and Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin] CTD PMID:16174794 daunorubicin increases secretion ISO NPC1 (Homo sapiens) 6480464 NPC1 protein results in increased secretion of Daunorubicin CTD PMID:16174794 daunorubicin affects response to substance ISO NPC1 (Homo sapiens) 6480464 NPC1 affects the susceptibility to Daunorubicin CTD PMID:16174794 dexamethasone multiple interactions ISO NPC1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA CTD PMID:28628672 diarsenic trioxide decreases expression ISO NPC1 (Homo sapiens) 6480464 Arsenic Trioxide results in decreased expression of NPC1 protein CTD PMID:25419056 doxorubicin decreases expression ISO NPC1 (Homo sapiens) 6480464 Doxorubicin results in decreased expression of NPC1 mRNA CTD PMID:29803840 endosulfan increases expression EXP 6480464 Endosulfan results in increased expression of NPC1 mRNA CTD PMID:29391264 epoxiconazole decreases expression ISO Npc1 (Mus musculus) 6480464 epoxiconazole results in decreased expression of NPC1 mRNA CTD PMID:35436446 ethanol increases expression ISO Npc1 (Mus musculus) 6480464 Ethanol results in increased expression of NPC1 mRNA CTD PMID:30319688 ethanol affects splicing ISO Npc1 (Mus musculus) 6480464 Ethanol affects the splicing of NPC1 mRNA CTD PMID:30319688 fenthion decreases expression ISO Npc1 (Mus musculus) 6480464 Fenthion results in decreased expression of NPC1 mRNA CTD PMID:34813904 fingolimod hydrochloride increases expression ISO NPC1 (Homo sapiens) 6480464 Fingolimod Hydrochloride results in increased expression of NPC1 protein CTD PMID:20056921 fingolimod hydrochloride multiple interactions ISO NPC1 (Homo sapiens) 6480464 NPC1 protein affects the reaction [Fingolimod Hydrochloride results in increased expression of ABCA1 protein] CTD PMID:20056921 fipronil decreases expression EXP 6480464 fipronil results in decreased expression of NPC1 mRNA CTD PMID:23962444 ganglioside GM1 affects localization ISO Npc1 (Mus musculus) 6480464 NPC1 affects the localization of G(M1) Ganglioside CTD PMID:12183525 gentamycin increases expression EXP 6480464 Gentamicins results in increased expression of NPC1 mRNA CTD PMID:33387578 indirubin increases expression ISO NPC1 (Homo sapiens) 6480464 indirubin results in increased expression of NPC1 mRNA CTD PMID:15056799 indometacin multiple interactions ISO NPC1 (Homo sapiens) 6480464 [INS protein co-treated with Dexamethasone co-treated with 1-Methyl-3-isobutylxanthine co-treated with Indomethacin co-treated with bisphenol F] results in decreased expression of NPC1 mRNA CTD PMID:28628672 iron atom decreases abundance ISO Npc1 (Mus musculus) 6480464 NPC1 gene mutant form results in decreased abundance of Iron CTD PMID:24901380 iron(0) decreases abundance ISO Npc1 (Mus musculus) 6480464 NPC1 gene mutant form results in decreased abundance of Iron CTD PMID:24901380 isotretinoin decreases expression ISO NPC1 (Homo sapiens) 6480464 Isotretinoin results in decreased expression of NPC1 mRNA CTD PMID:20436886 ivermectin decreases expression ISO NPC1 (Homo sapiens) 6480464 Ivermectin results in decreased expression of NPC1 protein CTD PMID:32959892 methylmercury chloride increases expression ISO NPC1 (Homo sapiens) 6480464 methylmercuric chloride results in increased expression of NPC1 mRNA CTD PMID:28001369 N-methyl-4-phenylpyridinium decreases expression ISO Npc1 (Mus musculus) 6480464 1-Methyl-4-phenylpyridinium results in decreased expression of NPC1 protein CTD PMID:26558463 nitric oxide decreases expression ISO Npc1 (Mus musculus) 6480464 Nitric Oxide deficiency results in decreased expression of NPC1 mRNA CTD PMID:15878706 nocodazole multiple interactions ISO NPC1 (Homo sapiens) 6480464 Nocodazole inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin] CTD PMID:16174794 ozone multiple interactions ISO Npc1 (Mus musculus) 6480464 [Air Pollutants results in increased abundance of [Ozone co-treated with Soot]] which results in decreased expression of NPC1 mRNA CTD PMID:34911549 paracetamol affects expression ISO Npc1 (Mus musculus) 6480464 Acetaminophen affects the expression of NPC1 mRNA CTD PMID:17562736 paracetamol increases expression EXP 6480464 Acetaminophen results in increased expression of NPC1 mRNA CTD PMID:33387578 paracetamol increases expression ISO NPC1 (Homo sapiens) 6480464 Acetaminophen results in increased expression of NPC1 mRNA CTD PMID:21420995 and PMID:29067470 phenobarbital affects expression ISO NPC1 (Homo sapiens) 6480464 Phenobarbital affects the expression of NPC1 mRNA CTD PMID:19159669 phenylpropanolamine increases expression ISO NPC1 (Homo sapiens) 6480464 Phenylpropanolamine results in increased expression of NPC1 mRNA CTD PMID:27756839 pirinixic acid decreases expression ISO Npc1 (Mus musculus) 6480464 pirinixic acid results in decreased expression of NPC1 mRNA CTD PMID:18445702 pirinixic acid multiple interactions ISO NPC1 (Homo sapiens) 6480464 [pirinixic acid binds to and results in increased activity of PPARA protein] which results in increased expression of NPC1 mRNA CTD PMID:19710929 pregnenolone 16alpha-carbonitrile decreases expression ISO Npc1 (Mus musculus) 6480464 Pregnenolone Carbonitrile results in decreased expression of NPC1 mRNA CTD PMID:28903501 progesterone multiple interactions ISO NPC1 (Homo sapiens) 6480464 Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Cholesterol] and Progesterone inhibits the reaction [NPC1 protein results in increased secretion of Daunorubicin] CTD PMID:16174794 resveratrol increases expression ISO NPC1 (Homo sapiens) 6480464 resveratrol results in increased expression of NPC1 mRNA CTD PMID:19371625 rotenone decreases expression ISO NPC1 (Homo sapiens) 6480464 Rotenone results in decreased expression of NPC1 mRNA CTD PMID:33512557 S-butyl-DL-homocysteine (S,R)-sulfoximine decreases expression ISO Npc1 (Mus musculus) 6480464 Buthionine Sulfoximine results in decreased expression of NPC1 mRNA CTD PMID:15878706 serpentine asbestos increases expression ISO NPC1 (Homo sapiens) 6480464 Asbestos and Serpentine results in increased expression of NPC1 mRNA CTD PMID:29523930 silicon dioxide increases expression ISO NPC1 (Homo sapiens) 6480464 Silicon Dioxide analog results in increased expression of NPC1 mRNA CTD PMID:25895662 sulforaphane decreases expression ISO Npc1 (Mus musculus) 6480464 sulforaphane results in decreased expression of NPC1 mRNA CTD PMID:30529165 sulforaphane increases expression ISO NPC1 (Homo sapiens) 6480464 sulforaphane results in increased expression of NPC1 mRNA CTD PMID:31838189 sulindac increases expression ISO NPC1 (Homo sapiens) 6480464 Sulindac results in increased expression of NPC1 mRNA CTD PMID:11906190 sunitinib increases expression ISO NPC1 (Homo sapiens) 6480464 Sunitinib results in increased expression of NPC1 mRNA CTD PMID:31533062 temozolomide decreases expression ISO NPC1 (Homo sapiens) 6480464 Temozolomide results in decreased expression of NPC1 mRNA CTD PMID:31758290 tert-butyl hydroperoxide increases expression ISO NPC1 (Homo sapiens) 6480464 tert-Butylhydroperoxide results in increased expression of NPC1 mRNA CTD PMID:15336504 tetrachloromethane decreases expression EXP 6480464 Carbon Tetrachloride results in decreased expression of NPC1 mRNA CTD PMID:31150632 tetrachloromethane affects expression ISO Npc1 (Mus musculus) 6480464 Carbon Tetrachloride affects the expression of NPC1 mRNA CTD PMID:31919559 thapsigargin increases expression ISO Npc1 (Mus musculus) 6480464 Thapsigargin results in increased expression of NPC1 protein CTD PMID:24648495 thioacetamide decreases expression EXP 6480464 Thioacetamide results in decreased expression of NPC1 mRNA CTD PMID:34492290 titanium dioxide increases expression ISO Npc1 (Mus musculus) 6480464 titanium dioxide results in increased expression of NPC1 mRNA CTD PMID:29264374 trichloroethene increases expression EXP 6480464 Trichloroethylene results in increased expression of NPC1 mRNA CTD PMID:33387578 trichostatin A affects expression ISO NPC1 (Homo sapiens) 6480464 trichostatin A affects the expression of NPC1 mRNA CTD PMID:28542535 troglitazone decreases expression ISO Npc1 (Mus musculus) 6480464 troglitazone results in decreased expression of NPC1 mRNA CTD PMID:28973697 urethane increases expression ISO NPC1 (Homo sapiens) 6480464 Urethane results in increased expression of NPC1 mRNA CTD PMID:28818685 valproic acid affects expression ISO NPC1 (Homo sapiens) 6480464 Valproic Acid affects the expression of NPC1 mRNA CTD PMID:25979313 valproic acid increases expression ISO NPC1 (Homo sapiens) 6480464 Valproic Acid results in increased expression of NPC1 mRNA CTD PMID:28001369 vinclozolin decreases expression EXP 6480464 vinclozolin results in decreased expression of NPC1 mRNA CTD PMID:23034163 Yessotoxin increases expression ISO NPC1 (Homo sapiens) 6480464 yessotoxin analog results in increased expression of NPC1 mRNA CTD PMID:30679557 zinc atom multiple interactions ISO NPC1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of NPC1 mRNA CTD PMID:18593933 zinc(0) multiple interactions ISO NPC1 (Homo sapiens) 6480464 [PCI 5002 co-treated with Zinc] results in increased expression of NPC1 mRNA CTD PMID:18593933
