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Gene: Npc1 (NPC intracellular cholesterol transporter 1) Rattus norvegicus
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Symbol: Npc1
Name: NPC intracellular cholesterol transporter 1
Description: Predicted to have cholesterol binding activity. Involved in negative regulation of cell death and response to cadmium ion. Predicted to localize to several cellular components, including the integral component of lysosomal membrane; membrane raft; and perinuclear region of cytoplasm. Human ortholog(s) of this gene implicated in Niemann-Pick disease type C1. Orthologous to human NPC1 (NPC intracellular cholesterol transporter 1); INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 6-propyl-2-thiouracil; ammonium chloride.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: Cdig2; Niemann-Pick disease, type C1; SLC66A1; solute carrier family 66 member 1
Orthologs:
Homo sapiens (human) : NPC1 (NPC intracellular cholesterol transporter 1)  HGNC  Alliance
Mus musculus (house mouse) : Npc1 (NPC intracellular cholesterol transporter 1)  MGI  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Npc1 (NPC intracellular cholesterol transporter 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NPC1 (NPC intracellular cholesterol transporter 1)
Canis lupus familiaris (dog) : NPC1 (NPC intracellular cholesterol transporter 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Npc1 (NPC intracellular cholesterol transporter 1)
Sus scrofa (pig) : NPC1 (NPC intracellular cholesterol transporter 1)
more info ...
Latest Assembly: Rnor_6.0 - RGSC Genome Assembly v6.0
Position:
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Rnor_6.0183,616,878 - 3,662,656 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl183,616,878 - 3,662,683 (-)Ensembl
Rnor_5.0183,626,015 - 3,671,677 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
RGSC_v3.4183,725,415 - 3,777,707 (-)NCBIRGSC3.4rn4RGSC3.4
RGSC_v3.1183,725,710 - 3,726,684 (-)NCBI
Celera183,239,322 - 3,285,547 (-)NCBICelera
Cytogenetic Map18p13NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (Rnor_6.0)
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Transcriptome
Promoters

Strain Variation

Strain Sequence Variants (Rnor 6.0)

Additional Information

External Database Links
Nomenclature History
RGD Curation Notes
 
More on Npc1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: rn5 rn6
NCBI Genome Data Viewer

RGD Object Information
RGD ID: 628693
Created: 2003-02-27
Species: Rattus norvegicus
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.