RGD Reference Report - Do tissue plasminogen activator-plasminogen activator inhibitor-1 complexes relate to the complications of insulin-dependent diabetes mellitus? Pittsburgh Epidemiology of Diabetes Complications Study. - Rat Genome Database

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Do tissue plasminogen activator-plasminogen activator inhibitor-1 complexes relate to the complications of insulin-dependent diabetes mellitus? Pittsburgh Epidemiology of Diabetes Complications Study.

Authors: Maser, RE  Ellis, D  Erbey, JR  Orchard, TJ 
Citation: Maser RE, etal., J Diabetes Complications. 1997 Jul-Aug;11(4):243-9.
RGD ID: 8547710
Pubmed: PMID:9201602   (View Abstract at PubMed)

The purpose of this study was to examine the potential relationship of tissue plasminogen activator-plasminogen activator inhibitor-1 (tPA-PAI-1) complexes and diabetic complications in individuals with insulin-dependent diabetes mellitus (IDDM). To address this issue, data from the third follow-up visit of participants in the Epidemiology of Diabetes Complications (EDC) study were examined. There were 454 participants, aged 32 +/- 8 years, with duration of IDDM of 23 +/- 8 years. Higher levels of tPA-PAI-1 complexes were seen for both men and women with IDDM complications. Specifically, statistically significant differences were seen in men with neuropathy (1.81 +/- 0.9 versus 1.42 +/- 0.8 ng/mL, p < 0.01), microalbuminuria (1.77 +/- 1.1 versus 1.35 +/- 0.6 ng/mL, p < 0.01), retinopathy (1.67 +/- 0.9 versus 1.43 +/- 0.8 ng/mL, p < 0.05), and lower extremity arterial disease (1.93 +/- 0.7 versus 1.50 +/- 0.9 ng/mL, p < 0.05) versus men without the particular complication. In women, higher complex levels were shown for those with retinopathy (1.51 +/- 0.8 versus 1.29 +/- 1.1 ng/mL, p < 0.01). Potential mechanisms for the relationship of higher complex levels and diabetic complications include an altered fibrinolytic response and/or insulin resistance. Because the results are cross sectional, it cannot be established whether the higher concentration of complexes is a result of the presence of complications or are antecedent. Prospective follow-up will be required to determine if tPA-PAI-1 complexes are predictive of the development of IDDM complications.



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Object Symbol
Species
Term
Qualifier
Evidence
With
Notes
Source
Original Reference(s)
SERPINE1HumanAlbuminuria  IEP associated with Diabetes Mellitus more ...RGD 
Serpine1RatAlbuminuria  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
Serpine1MouseAlbuminuria  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
SERPINE1Humandiabetic retinopathy  IEP associated with Diabetes Mellitus more ...RGD 
Serpine1Ratdiabetic retinopathy  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
Serpine1Mousediabetic retinopathy  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
SERPINE1Humanperipheral artery disease  IEP associated with Diabetes Mellitus more ...RGD 
Serpine1Ratperipheral artery disease  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
Serpine1Mouseperipheral artery disease  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
SERPINE1Humanpolyneuropathy  IEP associated with Diabetes Mellitus more ...RGD 
Serpine1Ratpolyneuropathy  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
Serpine1Mousepolyneuropathy  ISOSERPINE1 (Homo sapiens)associated with Diabetes Mellitus more ...RGD 
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Genes (Rattus norvegicus)
Serpine1  (serpin family E member 1)

Genes (Mus musculus)
Serpine1  (serine (or cysteine) peptidase inhibitor, clade E, member 1)

Genes (Homo sapiens)
SERPINE1  (serpin family E member 1)