SERPINE1 (serpin family E member 1) - Rat Genome Database

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Gene: SERPINE1 (serpin family E member 1) Homo sapiens
Symbol: SERPINE1
Name: serpin family E member 1
RGD ID: 69014
Description: Enables protease binding activity; serine-type endopeptidase inhibitor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of proteolysis; regulation of angiogenesis; and response to bacterium. Located in collagen-containing extracellular matrix and extracellular exosome. Implicated in several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune disease (multiple); diabetic retinopathy (multiple); lung disease (multiple); and sleep apnea (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; PAI1; PLANH1; plasminogen activator inhibitor 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
RGD Orthologs
Green Monkey
Naked Mole-Rat
Alliance Genes
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
NCBI Annotation Information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl7101,127,104 - 101,139,247 (+)EnsemblGRCh38hg38GRCh38
GRCh387101,127,104 - 101,139,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,770,385 - 100,782,528 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,557,172 - 100,569,026 (+)NCBINCBI36hg18NCBI36
Build 347100,363,886 - 100,375,741NCBI
Celera795,778,744 - 95,790,926 (+)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,363,553 - 95,375,745 (+)NCBIHuRef
CHM1_17100,700,705 - 100,712,867 (+)NCBICHM1_1
CRA_TCAGchr7v27100,128,757 - 100,140,934 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations     Click to see Annotation Detail View
abdominal aortic aneurysm  (ISO)
Acquired Protein C Deficiency  (ISO)
Acute Lung Injury  (ISO)
acute necrotizing pancreatitis  (IEP,ISO)
adult respiratory distress syndrome  (IEP)
Aggressive Fibromatosis  (IAGP)
Albuminuria  (IEP)
Alcoholic Fatty Liver  (ISO)
alcoholic liver cirrhosis  (IAGP)
allergic rhinitis  (ISO)
amyloidosis  (IAGP)
Animal Disease Models  (EXP)
anterolateral myocardial infarction  (ISO)
aortic aneurysm  (ISO)
Aortic Remodeling  (ISO)
Arterial Thrombosis  (ISO)
asthma  (IAGP,IEP,ISO)
atherosclerosis  (EXP)
autistic disorder  (EXP)
bacterial pneumonia  (ISO)
Banti's Syndrome  (IAGP)
Behcet's disease  (EXP,IEP)
brain ischemia  (ISO)
breast cancer  (IEP)
Bronchopulmonary Dysplasia  (IEP)
Cardiac Fibrosis  (ISO)
Carotid Artery Injuries  (ISO)
Central Serous Chorioretinopathy  (IEP)
cerebral infarction  (ISO)
Chemical and Drug Induced Liver Injury  (IAGP)
cholestasis  (EXP)
Choroidal Neovascularization, Experimental  (IMP,ISO)
Chronic Allograft Nephropathy  (IEP,IMP)
chronic obstructive pulmonary disease  (IEP,ISO)
Chronic Relapsing Experimental Autoimmune Encephalomyelitis  (ISO)
congestive heart failure  (EXP)
coronary artery disease  (IAGP)
Coronavirus infectious disease  (ISS)
Dermal Fibrosis  (ISO)
diabetes mellitus  (ISO)
diabetic angiopathy  (IAGP)
Diabetic Nephropathies  (EXP,IEP,ISO)
diabetic retinopathy  (IAGP,IEP)
disseminated intravascular coagulation  (ISO)
end stage renal disease  (EXP,ISO)
Endotoxemia  (ISO)
Experimental Autoimmune Encephalomyelitis  (ISO)
Experimental Diabetes Mellitus  (EXP,ISO)
familial combined hyperlipidemia  (IEP)
familial hypercholesterolemia  (IEP)
familial Mediterranean fever  (IAGP)
fatty liver disease  (EXP)
Fetal Growth Retardation  (IEP)
Fever  (IAGP)
fibrosarcoma  (ISO)
focal segmental glomerulosclerosis  (EXP,ISO)
glaucoma  (IEP)
glomerulonephritis  (IMP)
glomerulosclerosis  (ISO)
Graft vs Host Disease  (ISO)
Graves Ophthalmopathy  (IEP)
Graves' disease  (IDA,IEP)
head and neck squamous cell carcinoma  (IEP)
hematopoietic system disease  (ISO)
Hemorrhage  (ISO)
hemorrhagic disease  (IAGP)
high grade glioma  (IEP)
Hyaline Membrane Disease  (ISO)
hypertension  (EXP,IEP,ISO)
hyperthyroidism  (IEP)
Hypoxia-Ischemia, Brain  (IDA)
Insulin Resistance  (ISO)
interstitial lung disease  (IAGP)
Intestinal Polyps  (ISO)
Intestinal Reperfusion Injury  (ISO)
ischemic colitis  (IAGP)
limited scleroderma  (ISO)
liver cirrhosis  (IAGP)
liver disease  (EXP)
Liver Neoplasms  (EXP)
Liver Reperfusion Injury  (ISO)
lung disease  (IEP)
Lung Reperfusion Injury  (ISO)
macular degeneration  (IEP)
Metabolic Syndrome  (ISO)
middle cerebral artery infarction  (ISO)
Multiple Organ Failure  (ISO)
Multiple Trauma  (ISO)
muscular atrophy  (ISO)
myocardial infarction  (IAGP,ISO)
Myocardial Reperfusion Injury  (ISO)
Neointima  (IDA,ISO)
Neovascularization, Pathologic  (IEP)
nephrotic syndrome  (EXP)
nervous system disease  (EXP)
neurilemmoma  (IEP)
non-alcoholic fatty liver disease  (IEP)
Noonan syndrome  (IEP)
obesity  (EXP)
obstructive sleep apnea  (IEP)
oral squamous cell carcinoma  (IEP)
Oxygen-Induced Retinopathy  (ISO)
peripheral artery disease  (IEP)
Peritoneal Adhesions  (ISO)
Peritoneal Fibrosis  (IEP)
placental insufficiency  (IEP)
Plasminogen Activator Inhibitor-1 Deficiency  (IAGP)
platelet-type bleeding disorder 10  (IEP)
pleomorphic xanthoastrocytoma  (IAGP)
pleurisy  (IAGP)
pneumonia  (IAGP,IEP)
polycystic ovary syndrome  (IEP)
polycythemia  (ISO)
polyneuropathy  (IEP)
portal vein thrombosis  (IAGP)
Postoperative Atrial Fibrillation  (IEP)
pre-eclampsia  (EXP,IEP)
Pregnancy Complications  (IAGP)
proliferative diabetic retinopathy  (IAGP,IEP)
Prostatic Neoplasms  (EXP)
pulmonary fibrosis  (IDA,ISO)
pulmonary hypertension  (IAGP,IEP,ISO)
Radiation Nephropathy  (ISO)
relapsing-remitting multiple sclerosis  (IEP)
renal fibrosis  (ISO)
respiratory allergy  (EXP)
retinal vein occlusion  (IAGP,IEP)
retinopathy of prematurity  (IDA)
rhinitis  (IAGP)
Rhinosinusitis  (IEP)
sciatic neuropathy  (ISO)
Sepsis  (IEP,ISO)
sleep apnea  (IEP)
Stomach Neoplasms  (EXP)
Stroke  (IEP)
Sudden Hearing Loss  (IAGP)
systemic scleroderma  (IEP)
thoracic aortic aneurysm  (IEP)
thrombosis  (EXP,IAGP,IEP)
toxic shock syndrome  (IAGP)
transient cerebral ischemia  (ISO)
type 2 diabetes mellitus  (IAGP,IEP,ISO)
ureteral obstruction  (EXP,ISO)
urinary bladder cancer  (IDA)
uveal melanoma  (IMP)
Vascular Depression  (ISO)
Vascular Remodeling  (ISO)
Venous Thromboembolism  (IAGP)
Venous Thrombosis  (IAGP,ISO)
Ventilator-Induced Lung Injury  (ISO)
Wounds, Penetrating  (ISO)

Gene-Chemical Interaction Annotations     Click to see Annotation Detail View
(+)-catechin  (EXP)
(R)-adrenaline  (ISO)
(R)-noradrenaline  (ISO)
(S)-colchicine  (ISO)
(S)-naringenin  (ISO)
(S)-nicotine  (EXP,ISO)
1,1-dichloroethene  (ISO)
1,10-phenanthroline  (EXP)
1,2,4-trimethylbenzene  (ISO)
1,2-dimethylhydrazine  (ISO)
1-chloro-2,4-dinitrobenzene  (EXP)
1-naphthyl isothiocyanate  (EXP,ISO)
1-nitropyrene  (EXP)
15-deoxy-Delta(12,14)-prostaglandin J2  (ISO)
17alpha-ethynylestradiol  (EXP)
17beta-estradiol  (EXP,ISO)
17beta-hydroxy-17-methylestra-4,9,11-trien-3-one  (EXP)
17beta-hydroxy-5alpha-androstan-3-one  (EXP)
2,2',4,4'-Tetrabromodiphenyl ether  (EXP,ISO)
2,2,2-tetramine  (ISO)
2,3,7,8-tetrachlorodibenzodioxine  (EXP,ISO)
2,4-diaminotoluene  (ISO)
2,4-dichlorophenol  (EXP)
2,6-di-tert-butyl-4-methylphenol  (EXP)
2-amino-2-deoxy-D-galactopyranose  (ISO)
2-butoxyethanol  (ISO)
2-chloroethanol  (ISO)
2-hydroxypropanoic acid  (EXP)
3'-amino-3'-deoxy-N(6),N(6)-dimethyladenosine  (ISO)
3,3',4,4',5-pentachlorobiphenyl  (EXP,ISO)
3-(2,2-dichlorovinyl)-2,2-dimethylcyclopropanecarboxylic acid  (EXP)
3-\{1-[3-(dimethylamino)propyl]-1H-indol-3-yl\}-4-(1H-indol-3-yl)-1H-pyrrole-2,5-dione  (ISO)
3-isobutyl-1-methyl-7H-xanthine  (EXP,ISO)
3-methylcholanthrene  (EXP)
3-phenylprop-2-enal  (EXP)
4'-Methoxychalcone  (ISO)
4,4'-sulfonyldiphenol  (EXP,ISO)
4-aminophenol  (ISO)
4-Hydroxy-TEMPO  (ISO)
5-aza-2'-deoxycytidine  (EXP)
6-propyl-2-thiouracil  (ISO)
8-Br-cAMP  (EXP)
9-cis-retinoic acid  (EXP)
acetamide  (ISO)
acrolein  (ISO)
adenine  (ISO)
aflatoxin B1  (EXP,ISO)
aldehydo-D-glucose  (EXP,ISO)
aldosterone  (EXP,ISO)
all-trans-retinoic acid  (ISO)
aminoguanidine  (EXP,ISO)
ammonium chloride  (ISO)
amphibole asbestos  (EXP)
anthra[1,9-cd]pyrazol-6(2H)-one  (EXP,ISO)
antimonite  (EXP)
apocynin  (EXP)
arecoline  (ISO)
aristolochic acid  (EXP)
arsane  (EXP)
arsenic atom  (EXP)
arsenite(3-)  (EXP,ISO)
arsenous acid  (EXP,ISO)
aspalathin  (EXP)
atazanavir sulfate  (EXP)
atorvastatin calcium  (ISO)
atrazine  (EXP)
Aurin  (EXP)
azathioprine  (EXP)
barium chloride  (ISO)
benazepril  (ISO)
benzalkonium chloride  (ISO)
benzo[a]pyrene  (EXP,ISO)
benzo[b]fluoranthene  (ISO)
Benzo[k]fluoranthene  (ISO)
beta-naphthoflavone  (EXP,ISO)
bezafibrate  (EXP,ISO)
bicalutamide  (EXP)
bilirubin IXalpha  (EXP)
bis(2-ethylhexyl) phthalate  (EXP,ISO)
bisphenol A  (EXP,ISO)
Bisphenol A diglycidyl ether  (ISO)
bisphenol F  (EXP,ISO)
bleomycin A2  (ISO)
bortezomib  (ISO)
busulfan  (EXP)
butan-1-ol  (EXP)
butanal  (EXP)
Butylbenzyl phthalate  (ISO)
butyric acid  (ISO)
C.I. Natural Red 20  (ISO)
cadmium atom  (EXP,ISO)
cadmium dichloride  (EXP,ISO)
cadmium selenide  (EXP)
calciol  (ISO)
calcitriol  (EXP)
calcium atom  (EXP)
calcium(0)  (EXP)
camostat  (ISO)
cannabidiol  (EXP)
capsaicin  (EXP)
captan  (ISO)
carbamazepine  (EXP)
carbofuran  (ISO)
carbon nanotube  (EXP,ISO)
carbonyl cyanide p-trifluoromethoxyphenylhydrazone  (EXP)
chenodeoxycholic acid  (EXP,ISO)
chloroform  (ISO)
chloropicrin  (EXP)
chloroquine  (EXP)
chlorpyrifos  (ISO)
choline  (EXP,ISO)
chrysene  (ISO)
ciglitazone  (EXP)
cis-caffeic acid  (ISO)
cisplatin  (EXP,ISO)
clofibrate  (ISO)
clofibric acid  (EXP)
Clofop  (EXP)
clothianidin  (EXP)
cobalt atom  (EXP)
cobalt dichloride  (EXP)
copper atom  (EXP)
copper(0)  (EXP)
copper(II) sulfate  (EXP)
crocidolite asbestos  (EXP,ISO)
curcumin  (EXP)
cyanocob(III)alamin  (EXP)
cycloheximide  (EXP,ISO)
cyclophosphamide  (ISO)
cyclosporin A  (EXP,ISO)
D-glucose  (EXP,ISO)
daunorubicin  (EXP,ISO)
decabromodiphenyl ether  (ISO)
deoxycholic acid  (EXP,ISO)
dexamethasone  (EXP,ISO)
dextran sulfate  (ISO)
diarsenic trioxide  (EXP,ISO)
dibenz[a,h]anthracene  (ISO)
dibenzofuran  (ISO)
dibutyl phthalate  (ISO)
dichlorine  (ISO)
dichloroacetic acid  (ISO)
diclofenac  (EXP,ISO)
dicrotophos  (EXP)
dieldrin  (EXP)
dienogest  (EXP)
diethyl phthalate  (ISO)
diisobutyl phthalate  (ISO)
diisononyl phthalate  (ISO)
dinitrogen  (EXP)
dioxygen  (EXP,ISO)
dipotassium bis[mu-tartrato(4-)]diantimonate(2-) trihydrate  (EXP)
diquat  (EXP)
dorsomorphin  (EXP)
doxorubicin  (EXP,ISO)
efavirenz  (EXP)
emodin  (EXP)
enalapril  (ISO)
enalaprilat dihydrate  (ISO)
endosulfan  (ISO)
entinostat  (EXP)
eplerenone  (ISO)
eprosartan  (ISO)
Ethyl icosapentate  (ISO)
ethyl methanesulfonate  (EXP)
famotidine  (ISO)
fenofibrate  (EXP,ISO)
fipronil  (ISO)
flutamide  (ISO)
folic acid  (EXP,ISO)
formaldehyde  (EXP)
fosinopril  (ISO)
fructose  (ISO)
fulvestrant  (EXP)
fumonisin B1  (EXP)
geldanamycin  (EXP)
gemfibrozil  (EXP)
genistein  (EXP,ISO)
gentamycin  (ISO)
gestodene  (EXP)
glucose  (EXP,ISO)
glycochenodeoxycholic acid  (EXP)
glycocholic acid  (EXP)
glycodeoxycholic acid  (EXP)
Goe 6976  (ISO)
gold atom  (EXP)
gold(0)  (EXP)
graphite  (ISO)
guanethidine  (ISO)
GW 501516  (EXP)
heparin  (ISO)
hexadecanoic acid  (EXP)
Hexadimethrine bromide  (ISO)
Honokiol  (ISO)
hydralazine  (ISO)
hydrochlorothiazide  (ISO)
hydrogen chloride  (ISO)
hydrogen peroxide  (EXP,ISO)
hydrogen sulfide  (ISO)
hydroxychloroquine  (EXP)
hydroxyl  (EXP)
hypochlorous acid  (ISO)
indirubin-3'-monoxime  (EXP)
indometacin  (EXP)
ionomycin  (ISO)
iron(III) citrate  (EXP)
isobutanol  (EXP)
isoprenaline  (ISO)
isorhamnetin  (EXP,ISO)
isotretinoin  (ISO)
ivermectin  (ISO)
kainic acid  (ISO)
L-ascorbic acid  (ISO)
L-methionine  (ISO)
lactacystin  (EXP)
lead diacetate  (EXP)
leflunomide  (EXP)
levonorgestrel  (EXP)
linoleic acid  (ISO)
lipopolysaccharide  (EXP,ISO)
LY 364947  (ISO)
magnesium atom  (EXP)
magnesium dichloride  (EXP)
manganese atom  (EXP)
manganese(0)  (EXP)
manganese(II) chloride  (ISO)
mangiferin  (ISO)
Mecamylamine  (ISO)
medroxyprogesterone acetate  (EXP)
meglumine amidotrizoate  (ISO)
mercury dibromide  (EXP)
mercury dichloride  (ISO)
metaproterenol  (ISO)
metformin  (ISO)
methamphetamine  (ISO)
methapyrilene  (ISO)
methimazole  (ISO)
methotrexate  (EXP)
methyl beta-cyclodextrin  (EXP)
methyl methanesulfonate  (EXP)
methylmercury chloride  (EXP)
methylparaben  (EXP)
mifepristone  (EXP,ISO)
mitomycin C  (EXP)
mitoxantrone  (ISO)
monocrotaline  (ISO)
N-acetylsphingosine  (EXP)
N-methyl-N'-nitro-N-nitrosoguanidine  (ISO)
N-nitrosodiethylamine  (ISO)
N-Nitrosopyrrolidine  (EXP)
N1'-[2-[[5-[(dimethylamino)methyl]-2-furanyl]methylthio]ethyl]-N1-methyl-2-nitroethene-1,1-diamine  (ISO)
naphthalene  (ISO)
naphthalenes  (ISO)
nefazodone  (EXP)
nickel atom  (EXP)
nickel dichloride  (EXP,ISO)
nickel subsulfide  (EXP)
nickel sulfate  (ISO)
niclosamide  (ISO)
nicotine  (EXP,ISO)
nicotinic acid  (EXP,ISO)
nonanedioic acid  (EXP)
Nonidet P-40  (EXP)
norethisterone  (EXP)
notoginsenoside R1  (EXP,ISO)
obeticholic acid  (EXP)
ochratoxin A  (ISO)
octadecanoic acid  (ISO)
oleic acid  (EXP)
Olmesartan medoxomil  (ISO)
orciprenaline  (ISO)
oxaliplatin  (ISO)
ozone  (EXP,ISO)
p-chloromercuribenzoic acid  (EXP)
paclitaxel  (EXP)
palbociclib  (EXP)
paracetamol  (EXP,ISO)
paraquat  (EXP,ISO)
paricalcitol  (EXP)
pentane-2,3-dione  (ISO)
Pentoxifylline  (ISO)
perfluorononanoic acid  (EXP)
perfluorooctane-1-sulfonic acid  (ISO)
perfluorooctanoic acid  (EXP,ISO)
Phenelzine  (ISO)
phenethyl isothiocyanate  (EXP)
phenformin  (ISO)
phenobarbital  (ISO)
phentolamine  (ISO)
phenylephrine  (ISO)
phenylmercury acetate  (EXP)
phenytoin  (ISO)
phorbol 13-acetate 12-myristate  (EXP,ISO)
phosgene  (ISO)
phosphorus atom  (EXP)
phosphorus(.)  (EXP)
pioglitazone  (EXP,ISO)
pirfenidone  (ISO)
pirinixic acid  (EXP,ISO)
poly(I:C)  (EXP)
potassium chloride  (ISO)
potassium dichromate  (EXP)
procyanidin B3  (ISO)
progesterone  (EXP,ISO)
propanal  (EXP)
pyrrolidine dithiocarbamate  (EXP)
quercetin  (EXP)
quercetin 3-O-beta-D-glucofuranoside  (ISO)
quercetin 3-O-beta-D-glucopyranoside  (ISO)
quinolin-8-ol  (EXP)
rac-lactic acid  (EXP)
raloxifene  (EXP)
ranitidine  (ISO)
reserpine  (ISO)
resveratrol  (EXP,ISO)
rifampicin  (EXP,ISO)
rimonabant  (ISO)
rosmarinic acid  (EXP,ISO)
rotenone  (ISO)
S-butyl-DL-homocysteine (S,R)-sulfoximine  (ISO)
salvianolic acid B  (ISO)
saralasin  (ISO)
SB 203580  (ISO)
SB 431542  (EXP)
Securinine  (EXP)
serpentine asbestos  (ISO)
Shikonin  (ISO)
silicon dioxide  (EXP,ISO)
silver atom  (EXP)
silver(0)  (EXP)
simvastatin  (EXP,ISO)
sirolimus  (EXP,ISO)
sodium arsenate  (EXP)
sodium arsenite  (EXP,ISO)
sodium dichromate  (ISO)
sodium dodecyl sulfate  (EXP)
Soman  (ISO)
spironolactone  (EXP)
streptozocin  (ISO)
succimer  (ISO)
sulforaphane  (ISO)
sulindac sulfide  (EXP)
sunitinib  (EXP)
Sunset Yellow FCF  (EXP)
superoxide  (EXP)
tacrolimus hydrate  (ISO)
tamoxifen  (EXP)
tartrazine  (EXP)
taurocholic acid  (ISO)
telmisartan  (ISO)
temozolomide  (EXP)
tert-butyl hydroperoxide  (EXP)
Tesaglitazar  (ISO)
testosterone  (ISO)
tetrachloromethane  (ISO)
tetraphene  (ISO)
thiacloprid  (ISO)
thimerosal  (EXP)
thioacetamide  (ISO)
thiophanate-methyl  (ISO)
tibolone  (EXP)
titanium dioxide  (EXP,ISO)
topotecan  (EXP,ISO)
trans-caffeic acid  (ISO)
triadimefon  (EXP)
triamterene  (ISO)
trichloroethene  (ISO)
trichostatin A  (EXP)
triclosan  (EXP)
trimellitic anhydride  (ISO)
tris(2-butoxyethyl) phosphate  (EXP)
troglitazone  (EXP,ISO)
trovafloxacin  (ISO)
undecane  (ISO)
usnic acid  (EXP)
valproic acid  (EXP,ISO)
valsartan  (EXP,ISO)
vincaleukoblastine  (EXP,ISO)
vinclozolin  (ISO)
vincristine  (EXP,ISO)
vitamin E  (ISO)
wortmannin  (EXP)
zearalenone  (EXP)
zinc atom  (EXP,ISO)
zinc molecular entity  (EXP)
zinc pyrithione  (EXP)
zinc(0)  (EXP,ISO)
ziram  (ISO)

Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
angiogenesis  (IEP)
cellular response to aldosterone  (ISO)
cellular response to angiotensin  (ISO)
cellular response to ATP  (ISO)
cellular response to cAMP  (ISO)
cellular response to cGMP  (ISO)
cellular response to cycloheximide  (ISO)
cellular response to dexamethasone stimulus  (ISO)
cellular response to fibroblast growth factor stimulus  (ISO)
cellular response to follicle-stimulating hormone stimulus  (ISO)
cellular response to glucagon stimulus  (ISO)
cellular response to glucose stimulus  (ISO)
cellular response to gravity  (ISO)
cellular response to growth factor stimulus  (ISO)
cellular response to hydrogen peroxide  (ISO)
cellular response to hypoxia  (ISO)
cellular response to insulin stimulus  (ISO)
cellular response to interleukin-1  (ISO)
cellular response to leukemia inhibitory factor  (ISO)
cellular response to lipopolysaccharide  (IMP,ISO)
cellular response to low-density lipoprotein particle stimulus  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to metal ion  (ISO)
cellular response to nerve growth factor stimulus  (ISO)
cellular response to nicotine  (ISO)
cellular response to organic cyclic compound  (ISO)
cellular response to platelet-derived growth factor stimulus  (ISO)
cellular response to potassium ion  (ISO)
cellular response to resveratrol  (ISO)
cellular response to transforming growth factor beta stimulus  (ISO)
cellular response to xenobiotic stimulus  (ISO)
decidualization  (ISO)
defense response to Gram-negative bacterium  (IGI)
dentinogenesis  (IDA)
female gonad development  (ISO)
fibrinolysis  (TAS)
glucose homeostasis  (ISO)
mast cell activation  (ISO)
negative regulation of blood coagulation  (IC)
negative regulation of cell adhesion mediated by integrin  (IDA)
negative regulation of cell migration  (IDA,ISO)
negative regulation of endopeptidase activity  (IBA,IDA,ISO)
negative regulation of endothelial cell apoptotic process  (IMP)
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors  (IMP)
negative regulation of fibrinolysis  (IDA)
negative regulation of gene expression  (ISO)
negative regulation of plasminogen activation  (IBA,IDA,IMP)
negative regulation of smooth muscle cell migration  (IDA)
negative regulation of smooth muscle cell-matrix adhesion  (IDA)
negative regulation of vascular wound healing  (IBA,IGI)
negative regulation of wound healing  (IC)
placenta development  (ISO)
positive regulation of angiogenesis  (IMP,ISO)
positive regulation of blood coagulation  (IMP)
positive regulation of calcium ion import  (ISO)
positive regulation of coagulation  (ISO)
positive regulation of collagen biosynthetic process  (ISO)
positive regulation of epithelium regeneration  (ISO)
positive regulation of fibroblast proliferation  (ISO)
positive regulation of gene expression  (ISO)
positive regulation of inflammatory response  (IGI)
positive regulation of interleukin-8 production  (IMP)
positive regulation of keratinocyte migration  (ISO)
positive regulation of leukotriene production involved in inflammatory response  (IMP)
positive regulation of monocyte chemotaxis  (IMP)
positive regulation of odontoblast differentiation  (IDA)
positive regulation of receptor-mediated endocytosis  (IDA)
regulation of angiogenesis  (ISO)
regulation of cell population proliferation  (ISO)
regulation of signaling receptor activity  (IDA)
replicative senescence  (IMP)
response to cytokine  (ISO)
response to epidermal growth factor  (ISO)
response to estrogen  (ISO)
response to hyperoxia  (ISO)
response to laminar fluid shear stress  (ISO)
response to lipopolysaccharide  (ISO)
response to nutrient levels  (ISO)
response to reactive oxygen species  (ISO)
response to starvation  (ISO)
response to transforming growth factor beta  (ISO)
tissue regeneration  (ISO)

Cellular Component

Molecular Function


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