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Gene: SERPINE1 (serpin family E member 1) Homo sapiens
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Symbol: SERPINE1
Name: serpin family E member 1
Description: Exhibits protease binding activity; serine-type endopeptidase inhibitor activity; and signaling receptor binding activity. Involved in several processes, including negative regulation of proteolysis; regulation of angiogenesis; and response to bacterium. Localizes to the collagen-containing extracellular matrix and extracellular exosome. Implicated in several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); liver disease (multiple); and lung disease (multiple). Biomarker of several diseases, including artery disease (multiple); autoimmune hypersensitivity disease (multiple); eye disease (multiple); lung disease (multiple); and sleep apnea (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: endothelial plasminogen activator inhibitor; PAI; PAI-1; PAI1; PLANH1; plasminogen activator inhibitor 1; serine (or cysteine) proteinase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1; serpin E1; serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1
Orthologs:
Mus musculus (house mouse) : Serpine1 (serine (or cysteine) peptidase inhibitor, clade E, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Serpine1 (serpin family E member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Serpine1 (serpin family E member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SERPINE1 (serpin family E member 1)
Canis lupus familiaris (dog) : SERPINE1 (serpin family E member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Serpine1 (serpin family E member 1)
Sus scrofa (pig) : SERPINE1 (serpin family E member 1)
Chlorocebus sabaeus (green monkey) : SERPINE1 (serpin family E member 1)
Heterocephalus glaber (naked mole-rat) : Serpine1 (serpin family E member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl7101,127,104 - 101,139,247 (+)Ensembl
GRCh38 Ensembl7101,127,089 - 101,139,266 (+)Ensembl
GRCh387101,127,104 - 101,139,247 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377100,770,370 - 100,782,547 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367100,557,172 - 100,569,026 (+)NCBINCBI36hg18NCBI36
Build 347100,363,886 - 100,375,741NCBI
Celera795,778,744 - 95,790,926 (+)NCBI
Cytogenetic Map7q22.1NCBI
HuRef795,363,553 - 95,375,745 (+)NCBIHuRef
CHM1_17100,700,705 - 100,712,867 (+)NCBICHM1_1
CRA_TCAGchr7v27100,128,757 - 100,140,934 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


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Alliance Gene