MIR143 (microRNA 143) - Rat Genome Database

Send us a Message
Submit Data |  Help |  Video Tutorials |  News |  Publications |  Download |  REST API |  Citing RGD |  Contact   
Search RGD Grant Resources Citing RGD About Us Contact Us
Genes Variants Community Projects QTLs Strains Markers Genome Information Ontologies Cell Lines References Download Submit Data
OntoMate (Literature Search) JBrowse (Genome Browser) Synteny Browser (VCMap) Variant Visualizer Multi-Ontology Enrichment (MOET) Gene-Ortholog Location Finder (GOLF) InterViewer (Protein-Protein Interactions) PhenoMiner (Quatitative Phenotypes) Gene Annotator OLGA (Gene List Generator) AllianceMine GViewer (Genome Viewer)
Aging & Age-Related Disease Cancer & Neoplastic Disease Cardiovascular Disease Coronavirus Disease Developmental Disease Diabetes Hematologic Disease Immune & Inflammatory Disease Infectious Disease Liver Disease Neurological Disease Obesity & Metabolic Syndrome Renal Disease Respiratory Disease Sensory Organ Disease
Find Models Genetic Models Autism Models Rat PhenoMiner (Quantitative Phenotypes) Chinchilla PhenoMiner Expected Ranges (Quantitative Phenotype) PhenoMiner Term Comparison Hybrid Rat Diversity Panel Phenotypes Phenotypes in Other Animal Models Animal Husbandry Strain Medical Records Phylogenetics Strain Availability Calendar Rats 101 Submissions Photo Archive
Pathways
Rat Community Forum Directory of Rat Laboratories Video Tutorials News RGD Publications RGD Presentations Archive Nomenclature Guidelines Resource Links Laboratory Resources Employment Resources
Advanced Search (OLGA)
Gene: MIR143 (microRNA 143) Homo sapiens
Analyze
Symbol: MIR143
Name: microRNA 143
RGD ID: 1346221
HGNC Page HGNC:31530
Description: Enables mRNA 3'-UTR binding activity and mRNA base-pairing translational repressor activity. Involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of cell migration; and regulation of angiogenesis. Located in extracellular exosome. Biomarker of several diseases, including artery disease (multiple); colorectal cancer (multiple); congestive heart failure; periodontitis; and vascular dementia.
Type: ncrna (Ensembl: miRNA)
RefSeq Status: PROVISIONAL
Previously known as: mir-143; MIRN143
RGD Orthologs
Mouse
Rat
Dog
Pig
Alliance Orthologs
More Info more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,428,918 - 149,429,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,428,918 - 149,429,023 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,808,481 - 148,808,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,788,673 - 148,788,778 (+)NCBINCBI36Build 36hg18NCBI36
Celera5144,890,461 - 144,890,566 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,954,817 - 143,954,922 (+)NCBIHuRef
CHM1_15148,240,915 - 148,241,020 (+)NCBICHM1_1
T2T-CHM13v2.05149,963,763 - 149,963,868 (+)NCBIT2T-CHM13v2.0
JBrowse: View Region in Genome Browser (JBrowse)
Model


Gene Ontology Annotations     Click to see Annotation Detail View

Biological Process
actin cytoskeleton organization  (ISS)
angiotensin-activated signaling pathway  (ISS)
aorta smooth muscle tissue morphogenesis  (ISO,ISS)
cardiac vascular smooth muscle cell differentiation  (ISO)
cellular response to estrogen stimulus  (ISO)
cellular response to hypoxia  (ISO)
cellular response to mechanical stimulus  (ISO)
cellular response to tumor necrosis factor  (ISO)
embryo implantation  (ISO)
establishment or maintenance of cell type involved in phenotypic switching  (ISS)
gene expression  (ISO)
hematopoietic stem cell proliferation  (ISO)
miRNA-mediated gene silencing by inhibition of translation  (ISO)
miRNA-mediated post-transcriptional gene silencing  (IDA,IEA)
negative regulation of angiogenesis  (IDA)
negative regulation of D-glucose import  (ISS)
negative regulation of fat cell differentiation  (ISO)
negative regulation of insulin receptor signaling pathway  (ISO)
negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction  (ISO)
negative regulation of smooth muscle cell proliferation  (ISS)
positive regulation of adipose tissue development  (ISO)
positive regulation of angiogenesis  (IDA)
positive regulation of blood vessel endothelial cell migration  (IDA)
positive regulation of mesenchymal cell proliferation  (ISO)
positive regulation of pulmonary blood vessel remodeling  (ISS)
positive regulation of transcription by RNA polymerase II  (ISO)
positive regulation of vascular associated smooth muscle cell migration  (IDA)
regulation of glucose metabolic process  (ISO)
regulation of phenotypic switching  (ISS)
regulation of smooth muscle contraction  (ISS)
response to ischemia  (ISO)
response to muscle activity  (ISO)
transforming growth factor beta receptor signaling pathway  (ISO)

Cellular Component

Molecular Function

References

References - curated
# Reference Title Reference Citation
1. MicroRNA-143 Activation Regulates Smooth Muscle and Endothelial Cell Crosstalk in Pulmonary Arterial Hypertension. Deng L, etal., Circ Res. 2015 Oct 23;117(10):870-83. doi: 10.1161/CIRCRESAHA.115.306806. Epub 2015 Aug 26.
2. PVT1 regulates inflammation and cardiac function via the MAPK/NF-κB pathway in a sepsis model. Feng F, etal., Exp Ther Med. 2018 Dec;16(6):4471-4478. doi: 10.3892/etm.2018.6814. Epub 2018 Oct 1.
3. Long Non-coding RNA MALAT1/microRNA-143/VEGFA Signal Axis Modulates Vascular Endothelial Injury-Induced Intracranial Aneurysm. Gao G, etal., Nanoscale Res Lett. 2020 Jun 29;15(1):139. doi: 10.1186/s11671-020-03357-2.
4. MicroRNA-143 promotes cardiac ischemia-mediated mitochondrial impairment by the inhibition of protein kinase Cepsilon. Hong H, etal., Basic Res Cardiol. 2017 Sep 8;112(6):60. doi: 10.1007/s00395-017-0649-7.
5. Associations Between miRNAs and Two Different Cancers: Breast and Colon. Kundaktepe BP, etal., Cancer Manag Res. 2020 Feb 7;12:871-879. doi: 10.2147/CMAR.S227628. eCollection 2020.
6. P38 MAPK Signaling Pathway Mediates Angiotensin II-Induced miR143/145 Gene Cluster Downregulation during Aortic Dissection Formation. Li B, etal., Ann Vasc Surg. 2017 Apr;40:262-273. doi: 10.1016/j.avsg.2016.09.016. Epub 2017 Feb 4.
7. MicroRNA (miR)-597-5p Inhibits Colon Cancer Cell Migration and Invasion by Targeting FOS-Like Antigen 2 (FOSL2). Li S, etal., Front Oncol. 2019 Jun 12;9:495. doi: 10.3389/fonc.2019.00495. eCollection 2019.
8. MicroRNA-143 Increases Oxidative Stress and Myocardial Cell Apoptosis in a Mouse Model of Doxorubicin-Induced Cardiac Toxicity. Li XQ, etal., Med Sci Monit. 2020 Mar 14;26:e920394. doi: 10.12659/MSM.920394.
9. A Smooth Muscle Cell-Enriched Long Noncoding RNA Regulates Cell Plasticity and Atherosclerosis by Interacting With Serum Response Factor. Ni H, etal., Arterioscler Thromb Vasc Biol. 2021 Sep;41(9):2399-2416. doi: 10.1161/ATVBAHA.120.315911. Epub 2021 Jul 22.
10. Identification of a novel salivary biomarker miR-143-3p for periodontal diagnosis: A proof of concept study. Nisha KJ, etal., J Periodontol. 2019 Oct;90(10):1149-1159. doi: 10.1002/JPER.18-0729. Epub 2019 May 10.
11. Data Import for Chemical-Gene Interactions RGD automated import pipeline for gene-chemical interactions
12. MicroRNA-143 modulates the expression of Natriuretic Peptide Receptor 3 in cardiac cells. Wang J, etal., Sci Rep. 2018 May 4;8(1):7055. doi: 10.1038/s41598-018-25489-3.
13. The miR-143/145 cluster reverses the regulation effect of KLF5 in smooth muscle cells with proliferation and contractility in intracranial aneurysm. Xu J, etal., Gene. 2018 Dec 30;679:266-273. doi: 10.1016/j.gene.2018.09.010. Epub 2018 Sep 7.
14. Acupuncture attenuates cognitive impairments in vascular dementia through inhibiting miR-143-3p. Yang R, etal., Acta Biochim Pol. 2022 Dec 2;69(4):805-810. doi: 10.18388/abp.2020_6132.
15. Diagnostic value of microRNA-143 in predicting in-stent restenosis for patients with lower extremity arterial occlusive disease. Yu ZH, etal., Eur J Med Res. 2017 Jan 5;22(1):2. doi: 10.1186/s40001-016-0240-y.
16. Downregulation of miR143/145 gene cluster expression promotes the aortic media degeneration process via the TGF-β1 signaling pathway. Zhang M and Wang Z, Am J Transl Res. 2019 Jan 15;11(1):370-378. eCollection 2019.
Additional References at PubMed
PMID:12007417   PMID:14573789   PMID:15504739   PMID:16381832   PMID:17604727   PMID:17616659   PMID:19137007   PMID:19190970   PMID:19242066   PMID:19439999   PMID:19472311   PMID:19638978  
PMID:19855844   PMID:20094072   PMID:20158877   PMID:20167074   PMID:20363096   PMID:20525177   PMID:20620599   PMID:20809117   PMID:21037258   PMID:21159816   PMID:21197560   PMID:21218087  
PMID:21453382   PMID:21518477   PMID:21550168   PMID:21557394   PMID:21647377   PMID:21673106   PMID:21685392   PMID:21693658   PMID:21701675   PMID:21706045   PMID:21711110   PMID:21712382  
PMID:21790228   PMID:21943005   PMID:22093444   PMID:22108519   PMID:22160209   PMID:22194833   PMID:22327366   PMID:22330136   PMID:22354042   PMID:22457808   PMID:22469988   PMID:22533346  
PMID:22549179   PMID:22593586   PMID:22691140   PMID:22751122   PMID:22804917   PMID:22836856   PMID:22876303   PMID:22948942   PMID:23070684   PMID:23104321   PMID:23128394   PMID:23269581  
PMID:23276710   PMID:23297865   PMID:23321517   PMID:23339192   PMID:23376635   PMID:23397547   PMID:23476055   PMID:23574723   PMID:23628392   PMID:23661430   PMID:23804075   PMID:23811549  
PMID:23812417   PMID:23866094   PMID:23904792   PMID:23932921   PMID:23965966   PMID:23973710   PMID:23999936   PMID:24033605   PMID:24065523   PMID:24070896   PMID:24105952   PMID:24218337  
PMID:24283360   PMID:24284362   PMID:24286416   PMID:24333576   PMID:24474452   PMID:24577510   PMID:24616567   PMID:24626955   PMID:24746948   PMID:24752771   PMID:24774218   PMID:24909097  
PMID:24927876   PMID:24993656   PMID:25175415   PMID:25227664   PMID:25248370   PMID:25270212   PMID:25322940   PMID:25354797   PMID:25427155   PMID:25474488   PMID:25477374   PMID:25492481  
PMID:25527813   PMID:25529447   PMID:25562163   PMID:25576341   PMID:25616133   PMID:25637573   PMID:25655189   PMID:25701793   PMID:25801897   PMID:25804644   PMID:25961039   PMID:26252302  
PMID:26317418   PMID:26348397   PMID:26427659   PMID:26484567   PMID:26541455   PMID:26573388   PMID:26597530   PMID:26618772   PMID:26646696   PMID:26646931   PMID:26722463   PMID:26758433  
PMID:26762731   PMID:26823739   PMID:26824186   PMID:26825461   PMID:26905370   PMID:26916216   PMID:26993250   PMID:27048505   PMID:27075467   PMID:27081712   PMID:27093346   PMID:27121210  
PMID:27133034   PMID:27223470   PMID:27225861   PMID:27278606   PMID:27438131   PMID:27444415   PMID:27492459   PMID:27492780   PMID:27556691   PMID:27558843   PMID:27639060   PMID:27708363  
PMID:27748916   PMID:27767041   PMID:27827523   PMID:28109198   PMID:28121625   PMID:28134320   PMID:28174335   PMID:28187958   PMID:28194669   PMID:28252165   PMID:28270439   PMID:28272526  
PMID:28404925   PMID:28424493   PMID:28431233   PMID:28436387   PMID:28454844   PMID:28492554   PMID:28511343   PMID:28527816   PMID:28543721   PMID:28544557   PMID:28596604   PMID:28619512  
PMID:28633641   PMID:28716710   PMID:28716711   PMID:28718369   PMID:28724745   PMID:28734729   PMID:28746466   PMID:28765889   PMID:28775366   PMID:28803245   PMID:28933584   PMID:29022908  
PMID:29073169   PMID:29238081   PMID:29268817   PMID:29271989   PMID:29321084   PMID:29330462   PMID:29336659   PMID:29360495   PMID:29360852   PMID:29416013   PMID:29556721   PMID:29562274  
PMID:29566027   PMID:29674277   PMID:29693187   PMID:29741283   PMID:29867125   PMID:29923982   PMID:29925839   PMID:30004802   PMID:30050105   PMID:30098313   PMID:30126634   PMID:30132510  
PMID:30150287   PMID:30193605   PMID:30195228   PMID:30243086   PMID:30261196   PMID:30332984   PMID:30362514   PMID:30392876   PMID:30535502   PMID:30536996   PMID:30556875   PMID:30570849  
PMID:30595365   PMID:30755102   PMID:30825877   PMID:30840186   PMID:30854930   PMID:30878395   PMID:30883340   PMID:30930112   PMID:30959742   PMID:30991076   PMID:31001854   PMID:31032951  
PMID:31066120   PMID:31081880   PMID:31126193   PMID:31128037   PMID:31152816   PMID:31180557   PMID:31212858   PMID:31264280   PMID:31311326   PMID:31314552   PMID:31316517   PMID:31322249  
PMID:31378369   PMID:31407404   PMID:31443963   PMID:31514295   PMID:31521891   PMID:31544294   PMID:31593646   PMID:31638218   PMID:31654121   PMID:31661146   PMID:31691635   PMID:31738908  
PMID:31740975   PMID:31756170   PMID:31772686   PMID:31773699   PMID:31833800   PMID:31841194   PMID:31863330   PMID:31872875   PMID:32027760   PMID:32037092   PMID:32052500   PMID:32077199  
PMID:32152265   PMID:32196963   PMID:32227711   PMID:32337953   PMID:32339330   PMID:32445925   PMID:32449873   PMID:32508321   PMID:32520926   PMID:32568179   PMID:32599139   PMID:32617870  
PMID:32623445   PMID:32647147   PMID:32687246   PMID:32815005   PMID:32879299   PMID:32880825   PMID:32885590   PMID:32945436   PMID:33015157   PMID:33073957   PMID:33090550   PMID:33118120  
PMID:33130456   PMID:33141390   PMID:33230102   PMID:33238264   PMID:33285775   PMID:33287937   PMID:33382073   PMID:33484447   PMID:33549125   PMID:33577022   PMID:33577845   PMID:33649782  
PMID:33649787   PMID:33685293   PMID:33744906   PMID:33760149   PMID:33824420   PMID:33825830   PMID:33870836   PMID:33945535   PMID:33980135   PMID:33991434   PMID:34162418   PMID:34224325  
PMID:34387848   PMID:34428587   PMID:34435328   PMID:34485516   PMID:34515927   PMID:34551209   PMID:34654357   PMID:34681681   PMID:34695177   PMID:34807471   PMID:34822133   PMID:34893096  
PMID:34918978   PMID:34943951   PMID:34995817   PMID:35121085   PMID:35156321   PMID:35213273   PMID:35262384   PMID:35288625   PMID:35302725   PMID:35397570   PMID:35534864   PMID:35627259  
PMID:35639219   PMID:35662508   PMID:35717476   PMID:35794158   PMID:35818245   PMID:35887339   PMID:36077521   PMID:36142173   PMID:36181617   PMID:36213264   PMID:36455140   PMID:36528726  
PMID:36533675   PMID:36546770   PMID:36602629   PMID:36708044   PMID:36775328   PMID:36833398   PMID:36945942   PMID:37126984   PMID:37132497   PMID:37149661   PMID:37167274   PMID:37179125  
PMID:37596147   PMID:37605290   PMID:37666296   PMID:37721971   PMID:37812578   PMID:37815745   PMID:37827696   PMID:37962045   PMID:38117249   PMID:38412676   PMID:38457157   PMID:38674017  
PMID:38717032   PMID:38751015   PMID:38824534   PMID:38874783   PMID:38994765  


Genomics

Comparative Map Data
MIR143
(Homo sapiens - human)
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385149,428,918 - 149,429,023 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh38.p14 Ensembl5149,428,918 - 149,429,023 (+)EnsemblGRCh38hg38GRCh38
GRCh375148,808,481 - 148,808,586 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365148,788,673 - 148,788,778 (+)NCBINCBI36Build 36hg18NCBI36
Celera5144,890,461 - 144,890,566 (+)NCBICelera
Cytogenetic Map5q32NCBI
HuRef5143,954,817 - 143,954,922 (+)NCBIHuRef
CHM1_15148,240,915 - 148,241,020 (+)NCBICHM1_1
T2T-CHM13v2.05149,963,763 - 149,963,868 (+)NCBIT2T-CHM13v2.0
Mir143
(Mus musculus - house mouse)
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm391861,782,267 - 61,782,329 (-)NCBIGRCm39GRCm39mm39
GRCm39 Ensembl1861,782,267 - 61,782,329 (-)EnsemblGRCm39 Ensembl
GRCm381861,649,196 - 61,649,258 (-)NCBIGRCm38GRCm38mm10GRCm38
GRCm38.p6 Ensembl1861,649,196 - 61,649,258 (-)EnsemblGRCm38mm10GRCm38
MGSCv371861,808,850 - 61,808,912 (-)NCBIGRCm37MGSCv37mm9NCBIm37
Celera1862,931,991 - 62,932,053 (-)NCBICelera
Cytogenetic Map18E1NCBI
cM Map1834.64NCBI
Mir143
(Rattus norvegicus - Norway rat)
Rat AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCr81857,371,349 - 57,371,453 (-)NCBIGRCr8
mRatBN7.21855,101,006 - 55,101,110 (-)NCBImRatBN7.2mRatBN7.2
mRatBN7.2 Ensembl1855,101,006 - 55,101,110 (-)EnsemblmRatBN7.2 Ensembl
UTH_Rnor_SHR_Utx1857,194,722 - 57,194,826 (-)NCBIRnor_SHRUTH_Rnor_SHR_Utx
UTH_Rnor_SHRSP_BbbUtx_1.01857,909,333 - 57,909,437 (-)NCBIRnor_SHRSPUTH_Rnor_SHRSP_BbbUtx_1.0
UTH_Rnor_WKY_Bbb_1.01855,724,872 - 55,724,976 (-)NCBIRnor_WKYUTH_Rnor_WKY_Bbb_1.0
Rnor_6.01856,971,273 - 56,971,377 (-)NCBIRnor6.0Rnor_6.0rn6Rnor6.0
Rnor_6.0 Ensembl1856,971,273 - 56,971,377 (-)EnsemblRnor6.0rn6Rnor6.0
Rnor_5.01856,200,186 - 56,200,290 (-)NCBIRnor5.0Rnor_5.0rn5Rnor5.0
Celera1853,251,504 - 53,251,608 (-)NCBICelera
Cytogenetic Map18q12.1NCBI
MIR143
(Canis lupus familiaris - dog)
Dog AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
CanFam3.1459,534,535 - 59,534,589 (-)NCBICanFam3.1CanFam3.1canFam3CanFam3.1
CanFam3.1 Ensembl459,534,535 - 59,534,594 (-)EnsemblCanFam3.1canFam3CanFam3.1
Dog10K_Boxer_Tasha459,299,832 - 59,299,886 (-)NCBIDog10K_Boxer_Tasha
ROS_Cfam_1.0460,017,094 - 60,017,148 (-)NCBIROS_Cfam_1.0
ROS_Cfam_1.0 Ensembl460,017,094 - 60,017,153 (-)EnsemblROS_Cfam_1.0 Ensembl
UMICH_Zoey_3.1459,803,989 - 59,804,043 (-)NCBIUMICH_Zoey_3.1
UNSW_CanFamBas_1.0459,918,447 - 59,918,501 (-)NCBIUNSW_CanFamBas_1.0
UU_Cfam_GSD_1.0460,448,995 - 60,449,049 (-)NCBIUU_Cfam_GSD_1.0
MIR143
(Sus scrofa - pig)
Pig AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
Sscrofa11.1 Ensembl2150,578,738 - 150,578,817 (+)EnsemblSscrofa11.1susScr11Sscrofa11.1
Sscrofa11.12150,578,738 - 150,578,817 (+)NCBISscrofa11.1Sscrofa11.1susScr11Sscrofa11.1
Sscrofa10.22157,344,738 - 157,344,817 (+)NCBISscrofa10.2Sscrofa10.2susScr3


Clinical Variants
Name Type Condition(s) Position(s) Clinical significance
GRCh38/hg38 5q23.3-33.2(chr5:130860928-155321811)x3 copy number gain See cases [RCV000051193] Chr5:130860928..155321811 [GRCh38]
Chr5:130196621..154701371 [GRCh37]
Chr5:130224520..154681564 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q21.3-33.2(chr5:106619588-156124387)x1 copy number loss See cases [RCV000053524] Chr5:106619588..156124387 [GRCh38]
Chr5:105955289..155551397 [GRCh37]
Chr5:105983188..155483975 [NCBI36]
Chr5:5q21.3-33.2		 pathogenic
GRCh38/hg38 5q23.3-33.2(chr5:129847794-153353546)x3 copy number gain See cases [RCV000138808] Chr5:129847794..153353546 [GRCh38]
Chr5:129183487..152733106 [GRCh37]
Chr5:129211386..152713299 [NCBI36]
Chr5:5q23.3-33.2		 pathogenic
GRCh38/hg38 5q31.3-32(chr5:141089988-149530678)x3 copy number gain See cases [RCV000139504] Chr5:141089988..149530678 [GRCh38]
Chr5:140469572..148910241 [GRCh37]
Chr5:140449756..148890434 [NCBI36]
Chr5:5q31.3-32		 pathogenic
GRCh37/hg19 5q15-35.3(chr5:94844077-178830410)x3 copy number gain not provided [RCV000487658] Chr5:94844077..178830410 [GRCh37]
Chr5:5q15-35.3		 likely benign
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910)x3 copy number gain See cases [RCV000449349] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789) copy number gain See cases [RCV000510723] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5q21.3-35.3(chr5:106716357-180687338)x3 copy number gain See cases [RCV000448245] Chr5:106716357..180687338 [GRCh37]
Chr5:5q21.3-35.3		 pathogenic
GRCh37/hg19 5q31.3-32(chr5:141113273-149154835)x1 copy number loss See cases [RCV000510497] Chr5:141113273..149154835 [GRCh37]
Chr5:5q31.3-32		 pathogenic
GRCh37/hg19 5p15.1-q35.2(chr5:17628741-176575720)x1 copy number loss See cases [RCV000511978] Chr5:17628741..176575720 [GRCh37]
Chr5:5p15.1-q35.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:113577-180719789)x3 copy number gain See cases [RCV000512039] Chr5:113577..180719789 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
NC_000005.9:g.(?_86400000)_(154000000_?)del deletion Familial adenomatous polyposis 1 [RCV004561496]|Hereditary cancer-predisposing syndrome [RCV000554476] Chr5:86400000..154000000 [GRCh37]
Chr5:5q14.3-33.2		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:25328-180693344)x3 copy number gain not provided [RCV000744323] Chr5:25328..180693344 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
GRCh37/hg19 5p15.33-q35.3(chr5:13648-180905029)x3 copy number gain not provided [RCV000744317] Chr5:13648..180905029 [GRCh37]
Chr5:5p15.33-q35.3		 pathogenic
Single allele deletion Neurodevelopmental disorder [RCV000787436] Chr5:14685137..149511942 [GRCh37]
Chr5:5p15.2-q32		 uncertain significance
GRCh37/hg19 5q31.3-32(chr5:140424333-148985999)x3 copy number gain not provided [RCV000848228] Chr5:140424333..148985999 [GRCh37]
Chr5:5q31.3-32		 uncertain significance
GRCh37/hg19 5q23.3-33.3(chr5:130125085-157574910) copy number gain not specified [RCV002053526] Chr5:130125085..157574910 [GRCh37]
Chr5:5q23.3-33.3		 pathogenic
NC_000005.9:g.(?_147774340)_(149681936_?)del deletion not provided [RCV003116332] Chr5:147774340..149681936 [GRCh37]
Chr5:5q32		 uncertain significance
GRCh37/hg19 5q32(chr5:147164969-149315489)x1 copy number loss not provided [RCV002473891] Chr5:147164969..149315489 [GRCh37]
Chr5:5q32		 pathogenic
miRNA Target Status

Confirmed Targets
Gene TargetMature miRNAMethod NameResult TypeData TypeSupport TypePMID
DNMT3Ahsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI19638978
SERPINE1hsa-miR-143-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCR//WeFunctional MTI22108519
FNDC3Bhsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI19472311
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoIn situ hybridization//qRT-PCR//Western blotFunctional MTI17504027
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Western blotNon-Functional MTI19157460
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoWestern blot//Luciferase reporter assay//Western bFunctional MTI19464056
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//Western blotFunctional MTI19855844
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI17892514
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//Microarray//Northern blFunctional MTI15504739
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI16966691
MAPK7hsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI16969504
COL1A1hsa-miR-143-3pMirtarbaseexternal_infoImmunoblot//Luciferase reporter assay//qRT-PCRNon-Functional MTI19913496
HRAShsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//Northern blot//qRT-PCRFunctional MTI21276449
FSCN1hsa-miR-143-3pMirtarbaseexternal_infoWestern blotNon-Functional MTI21218087
FSCN1hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22457808
HK2hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22354042
HK2hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22593586
HK2hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI23376635
AKT1hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI23104321
MDM2hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI22330136
MMP13hsa-miR-143-3pMirtarbaseexternal_infoWestern blot;MicroarrayFunctional MTI21427707
MAPK7hsa-miR-143-3pTarbaseexternal_infoOtherPOSITIVE
MAPK7hsa-miR-143-3pTarbaseexternal_infoWesternblitPOSITIVE
FNDC3Bhsa-miR-143-3pOncomiRDBexternal_infoNANA23383988
MAPK7hsa-miR-143-3pOncomiRDBexternal_infoNANA23276710
CD44hsa-miR-143-3pOncomiRDBexternal_infoNANA23128394
AKT1hsa-miR-143-3pOncomiRDBexternal_infoNANA23104321
ARHGEF1hsa-miR-143-3pOncomiRDBexternal_infoNANA23070684
HK2hsa-miR-143-3pOncomiRDBexternal_infoNANA22691140
HK2hsa-miR-143-3pOncomiRDBexternal_infoNANA22593586
MACC1hsa-miR-143-3pOncomiRDBexternal_infoNANA22533346
HK2hsa-miR-143-3pOncomiRDBexternal_infoNANA22469988
FSCN1hsa-miR-143-3pOncomiRDBexternal_infoNANA22457808
MDM2hsa-miR-143-3pOncomiRDBexternal_infoNANA22330136
BCL2hsa-miR-143-3pOncomiRDBexternal_infoNANA22260523
SERPINE1hsa-miR-143-3pOncomiRDBexternal_infoNANA22108519
FHIThsa-miR-143-3pOncomiRDBexternal_infoNANA21711110
PRC1hsa-miR-143-3pOncomiRDBexternal_infoNANA21693658
MAPK7hsa-miR-143-3pOncomiRDBexternal_infoNANA21550168
KRAShsa-miR-143-3pOncomiRDBexternal_infoNANA21159816
BCL2hsa-miR-143-3pOncomiRDBexternal_infoNANA20878132
MYO6hsa-miR-143-3pOncomiRDBexternal_infoNANA20353999
MAPK4hsa-miR-143-3pOncomiRDBexternal_infoNANA19855844
DNMT3Ahsa-miR-143-3pOncomiRDBexternal_infoNANA19638978
FNDC3Bhsa-miR-143-3pOncomiRDBexternal_infoNANA19472311
KRAShsa-miR-143-3pOncomiRDBexternal_infoNANA19137007
MAPK7hsa-miR-143-3pOncomiRDBexternal_infoNANA17892514
MAPK7hsa-miR-143-3pOncomiRDBexternal_infoNANA16969504
MAPK7hsa-miR-143-5pMirecordsexternal_infoNANA15504739
KRAShsa-miR-143-5pMirecordsexternal_infoNANA19137007
MAPK7hsa-miR-143-5pMirecordsexternal_infoNANA19855844
FNDC3Bhsa-miR-143-5pMirecordsexternal_info{unchanged}NA19472311
MAPK7hsa-miR-143-5pMirecordsexternal_info{unchanged}NA19439999
BCL2hsa-miR-143-3pOncomiRDBexternal_infoNANA22160209
BCL2hsa-miR-143-5pMirecordsexternal_infoNANA20878132
MACC1hsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//Western blotFunctional MTI22533346
KRAShsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Western blotFunctional MTI19157460
KRAShsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assay//qRT-PCR//MicroarrayFunctional MTI19137007
KRAShsa-miR-143-3pMirtarbaseexternal_infoWestern blotFunctional MTI23276710
MYO6hsa-miR-143-3pMirtarbaseexternal_infoqRT-PCR//Luciferase reporter assay//Western blotFunctional MTI20353999
MYO6hsa-miR-143-3pMirtarbaseexternal_infoWestern blotFunctional MTI19843160
FHIThsa-miR-143-3pMirtarbaseexternal_infoLuciferase reporter assayFunctional MTI21711110
MT-CO2hsa-miR-143-3pMirtarbaseexternal_infoMicroarrayFunctional MTI (Weak)17875710
MT-CO2hsa-miR-143-3pOncomiRDBexternal_infoNANA21790228

Predicted Targets
Summary Value
Count of predictions:39204
Count of gene targets:13763
Count of transcripts:27656
Interacting mature miRNAs:hsa-miR-143-3p, hsa-miR-143-5p
Prediction methods:Microtar, Miranda, Pita, Rnahybrid, Targetscan
Result types:miRGate_prediction

The detailed report is available here: Full Report CSV TAB Printer

miRNA Target Status data imported from miRGate (http://mirgate.bioinfo.cnio.es/).
For more information about miRGate, see PMID:25858286 or access the full paper here.


QTLs in Region (GRCh38)
The following QTLs overlap with this region.    Full Report CSV TAB Printer Gviewer
RGD IDSymbolNameLODP ValueTraitSub TraitChrStartStopSpecies
1357314AASTH54_HAllergic/atopic asthma related QTL 54 (human)3.560.0003Reversible airflow obstructiontotal serum IgE5135892246150155845Human


Sequence


Ensembl Acc Id: ENST00000385300
Type: CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh38.p14 Ensembl5149,428,918 - 149,429,023 (+)Ensembl
RefSeq Acc Id: NR_029684
RefSeq Status: PROVISIONAL
Type: NON-CODING
Position:
Human AssemblyChrPosition (strand)Source
GRCh385149,428,918 - 149,429,023 (+)NCBI
GRCh375148,808,481 - 148,808,586 (+)ENTREZGENE
HuRef5143,954,817 - 143,954,922 (+)ENTREZGENE
CHM1_15148,240,915 - 148,241,020 (+)NCBI
T2T-CHM13v2.05149,963,763 - 149,963,868 (+)NCBI
Sequence:

Additional Information

Database Acc Id Source(s)
AGR Gene HGNC:31530 AgrOrtholog
COSMIC MIR143 COSMIC
Ensembl Genes ENSG00000284182 Ensembl, ENTREZGENE
Ensembl Transcript ENST00000385300 ENTREZGENE
GTEx ENSG00000284182 GTEx
HGNC ID HGNC:31530 ENTREZGENE
Human Proteome Map MIR143 Human Proteome Map
miRBase MI0000459 ENTREZGENE
NCBI Gene 406935 ENTREZGENE
OMIM 612117 OMIM
PharmGKB PA164722492 PharmGKB
RNAcentral URS0000008A99 RNACentral
  URS00003E93AB RNACentral
  URS00005C2A6D RNACentral