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GENE - CHEMICAL INTERACTIONS REPORT

RGD ID: 69014
Species: Homo sapiens
RGD Object: Gene
Symbol: SERPINE1
Name: serpin family E member 1
Acc ID: CHEBI:69478
Term: cannabidiol
Definition: An cannabinoid that is cyclohexene which is substituted by a methyl group at position 1, a 2,6-dihydroxy-4-pentylphenyl group at position 3, and a prop-1-en-2-yl group at position 4.
Chemical ID: MESH:D002185
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction is comprised of a complex set of reactions and/or regulatory events, possibly involving additional chemicals and/or gene products.
Object SymbolQualifierEvidenceWithReferenceSourceNotesOriginal Reference(s)
SERPINE1decreases expressionEXP 6480464CTDCannabidiol results in decreased expression of SERPINE1 mRNAPMID:20668920
SERPINE1decreases secretionEXP 6480464CTDCannabidiol results in decreased secretion of SERPINE1 proteinPMID:20668920
SERPINE1increases response to substanceEXP 6480464CTDSERPINE1 protein results in increased susceptibility to CannabidiolPMID:20668920
SERPINE1multiple interactionsEXP 6480464CTDCannabidiol inhibits the reaction [TNF protein results in increased expression of SERPINE1 mRNA]; CNR1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]; CNR2 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]; TRPV1 protein promotes the reaction [Cannabidiol results in decreased secretion of SERPINE1 protein]PMID:20668920 PMID:31250491
SERPINE1increases expressionISOSerpine1 (Mus musculus)6480464CTDCannabidiol analog results in increased expression of SERPINE1 proteinPMID:30382123
SERPINE1multiple interactionsISOSerpine1 (Mus musculus)6480464CTDCannabidiol analog inhibits the reaction [Bleomycin results in decreased expression of SERPINE1 protein]; Cannabidiol analog promotes the reaction [Dietary Fats results in increased expression of SERPINE1 protein]PMID:30382123 PMID:30825431
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