GENE - CHEMICAL INTERACTIONS REPORT
Note: Use of the qualifier "multiple interactions" designates that the annotated interaction
is comprised of a complex set of reactions and/or regulatory events, possibly involving
additional chemicals and/or gene products.
Object Symbol | Qualifier | Evidence | With | Reference | Source | Notes | Original Reference(s) | SERPINE1 | increases methylation | EXP | | 6480464 | CTD | Choline results in increased methylation of SERPINE1 gene | PMID:30116142 | SERPINE1 | multiple interactions | EXP | | 6480464 | CTD | [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased expression of SERPINE1 mRNA; [Choline co-treated with Vitamin B 12 co-treated with Folic Acid] results in increased methylation of SERPINE1 gene | PMID:30116142 | SERPINE1 | multiple interactions | ISO | Serpine1 (Mus musculus) | 6480464 | CTD | 3,4,5,3',4'-pentachlorobiphenyl promotes the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein]; [3,4,5,3',4'-pentachlorobiphenyl co-treated with Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with 3,4,5,3',4'-pentachlorobiphenyl] results in increased expression of SERPINE1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with aroclor 1260] affects the expression of SERPINE1 mRNA; [Methionine deficiency co-treated with Choline deficiency co-treated with Folic Acid deficiency] results in increased expression of SERPINE1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA; [Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 protein; Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]; NR0B2 protein promotes the reaction [Fenofibrate inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA]]; pirinixic acid inhibits the reaction [[Methionine deficiency co-treated with Choline deficiency] results in increased expression of SERPINE1 mRNA] | PMID:19593819 PMID:20938992 PMID:28163111 PMID:28973532 | | ||||||||||||||||||||||
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